1 1319 121 HEART RATE VARIABILITY, FLOW, MOOD AND MENTAL STRESS DURING YOGA PRACTICES IN YOGA PRACTITIONERS, NON-YOGA PRACTITIONERS AND PEOPLE WITH METABOLIC SYNDROME. HEART RATE VARIABILITY (HRV) AND RESPIRATORY SINUS ARRHYTHMIA ARE DIRECTLY ASSOCIATED WITH AUTONOMIC FLEXIBILITY, SELF-REGULATION AND WELL-BEING, AND INVERSELY ASSOCIATED WITH PHYSIOLOGICAL STRESS, PSYCHOLOGICAL STRESS AND PATHOLOGY. YOGA ENHANCES AUTONOMIC ACTIVITY, MITIGATES STRESS AND BENEFITS STRESS-RELATED CLINICAL CONDITIONS, YET THE RELATIONSHIP BETWEEN AUTONOMIC ACTIVITY AND PSYCHOPHYSIOLOGICAL RESPONSES DURING YOGA PRACTICES AND STRESSFUL STIMULI HAS NOT BEEN WIDELY EXPLORED. THIS EXPERIMENTAL STUDY EXPLORED THE RELATIONSHIP BETWEEN HRV, MOOD STATES AND FLOW EXPERIENCES IN REGULAR YOGA PRACTITIONERS (YP), NON-YOGA PRACTITIONERS (NY) AND PEOPLE WITH METABOLIC SYNDROME (METS), DURING MENTAL ARITHMETIC STRESS TEST (MAST) AND VARIOUS YOGA PRACTICES. THE STUDY FOUND THAT THE MAST PLACED A CARDIO-AUTONOMIC BURDEN IN ALL PARTICIPANTS WITH THE YP GROUP SHOWING THE GREATEST REACTIVITY AND THE MOST RAPID RECOVERY, WHILE THE METS GROUP HAD SIGNIFICANTLY BLUNTED RECOVERY. THE YP GROUP ALSO REPORTED A HEIGHTENED EXPERIENCE OF FLOW AND POSITIVE MOOD STATES COMPARED TO NY AND METS GROUPS AS WELL AS HAVING A HIGHER VAGAL TONE DURING ALL RESTING CONDITIONS. THESE RESULTS SUGGEST YOGA PRACTITIONERS HAVE A GREATER HOMEOSTATIC CAPACITY AND AUTONOMIC, METABOLIC AND PHYSIOLOGICAL RESILIENCE. FURTHER STUDIES ARE NOW NEEDED TO DETERMINE IF REGULAR YOGA PRACTICE MAY IMPROVE AUTONOMIC FLEXIBILITY IN NON-YOGA PRACTITIONERS AND METABOLIC SYNDROME PATIENTS. CLINICAL TRIAL NO 'ACTRN 2614001075673'. 2016
2 2760 45 YOGA PRACTITIONERS UNIQUELY ACTIVATE THE SUPERIOR PARIETAL LOBULE AND SUPRAMARGINAL GYRUS DURING EMOTION REGULATION. CHRONIC STRESS CONTRIBUTES TO BOTH MENTAL AND PHYSICAL ILLNESS. A HIGH PREVALENCE AND COST OF STRESS-RELATED ILLNESSES NORTH AMERICA WARRANTS INVESTIGATION INTO ALTERNATIVE OR COMPLEMENTARY THERAPIES WHICH MAY HELP REDUCE ADVERSE REACTIONS TO STRESSFUL STIMULI. EMOTION REGULATION IS THE PROCESS OF MONITORING AND ADJUSTING EMOTIONAL RESPONSES TO ENVIRONMENTAL STIMULI AND STRESSORS. INDIVIDUALS WHO PARTICIPATE IN PHYSICAL ACTIVITY ARE LESS LIKELY TO HAVE ADVERSE RESPONSES TO POTENTIALLY STRESSFUL SITUATIONS, POTENTIALLY DUE TO ADAPTIONS IN EMOTION REGULATION. YOGA IS A FORM OF PHYSICAL ACTIVITY INVOLVING STRETCHING EXERCISES AND MEDITATION, THAT MAY LESSEN INDIVIDUALS' LEVELS OF STRESS AND ANXIETY AND IMPROVE EMOTION REGULATION. HIGH-FREQUENCY HEART RATE VARIABILITY (HF-HRV) IS CONSIDERED A MEASURE OF PARASYMPATHETIC NERVOUS SYSTEM (PNS) ACTIVITY DURING THE EMOTION REGULATION. MEASURING HRV AND BRAIN ACTIVITY USING FUNCTIONAL MAGNETIC RESONANCE IMAGING (FMRI) OFFERS A USEFUL, NONINVASIVE APPROACH TO EVALUATING "NEUROVISCERAL" COMPONENTS OF EMOTION REGULATION. WE AIMED TO DETERMINE WHETHER YOGA PRACTITIONERS (YP) EXHIBIT DIFFERENT PATTERNS OF BRAIN ACTIVATION COMPARED TO RECREATIONAL ATHLETES (RA) WITHOUT CURRENT YOGA EXPERIENCE, WHILE VIEWING EMOTIONALLY AROUSING VISUAL STIMULI. OUR SECONDARY AIM WAS TO EXAMINE POTENTIAL DIFFERENCES ACROSS GROUPS IN HRV THROUGHOUT THE PRESENTATION OF THESE STIMULI. ANALYSIS OF FMRI DATA DURING EXPOSURE TO EMOTION-EVOKING (EE) STIMULI REVEALED THAT THE YP GROUP ACTIVATED TWO UNIQUE BRAIN AREAS, NAMELY THE SUPERIOR PARIETAL LOBULE AND THE SUPRAMARGINAL GYRUS. THESE AREAS HAVE BEEN ASSOCIATED WITH ATTENTIONAL AWARENESS AND REDUCED EGOCENTRIC BIAS, PROCESSES THAT HAVE BEEN IMPLICATED IN EMOTION REGULATION BY OTHERS. THE RA GROUP ACTIVATED THE INFERIOR MIDDLE FRONTAL CORTEX, AN AREA ASSOCIATED WITH COGNITIVE REAPPRAISAL DURING EMOTION REGULATION. THE YP GROUP ALSO DEMONSTRATED A TREND TOWARDS A HIGHER RATIO OF LOW- TO HIGH-FREQUENCY HRV COMPARED TO THE RA GROUP. THE PRESENT FINDINGS SUPPORT THE PRESENCE OF EXPERIENCE-DEPENDENT NEUROVISCERAL MECHANISMS ASSOCIATED WITH EMOTION REGULATION. INDIVIDUALS WHO PRACTICE YOGA REGULATE THEIR NEUROVISCERAL RESPONSES TO POTENTIALLY STRESSFUL EXTERNAL STIMULI IN A DIFFERENT MANNER THAN RECREATIONAL ATHLETES WHO DO NOT ENGAGE IN YOGA PRACTICE. THE PRESENT STUDY HAD A SMALL SAMPLE SIZE (RA: N = 12; YP: N = 19), WHICH SHOULD BE TAKEN INTO ACCOUNT WHEN INTERPRETING THE RESULTS. 2018
3 169 29 A RANDOMIZED CONTROLLED PILOT STUDY ASSESSING FEASIBILITY AND IMPACT OF YOGA PRACTICE ON QUALITY OF LIFE, MOOD, AND PERCEIVED STRESS IN WOMEN WITH NEWLY DIAGNOSED BREAST CANCER. BACKGROUND: A BREAST CANCER DIAGNOSIS CAN ENTAIL NUMEROUS PHYSICAL AND PSYCHOSOCIAL CHALLENGES. YOGA PRACTICE (YP) MAY CONTRIBUTE TO IMPROVED WELL-BEING FOR THESE PATIENTS. PRIMARY STUDY OBJECTIVE: INVESTIGATE FEASIBILITY AND IMPACT OF YP ON QUALITY OF LIFE (QOL), MOOD, FATIGUE, AND PERCEIVED STRESS IMMEDIATELY AFTER BREAST CANCER DIAGNOSIS. METHODS: THIRTY WOMEN WERE RANDOMLY ASSIGNED TO A YOGA GROUP (YG) OR CONTROL GROUP (CG) IMMEDIATELY AFTER CANCER DIAGNOSIS. SETTING: PILOT STUDY CONDUCTED AT AN ACADEMIC MEDICAL CENTER BREAST CLINIC. PARTICIPANTS: FEMALES (N = 30) WHO RECEIVED A BIOPSY-PROVEN BREAST CANCER DIAGNOSIS WITHOUT METASTATIC DISEASE. INTERVENTION YG: ONE INDIVIDUAL YP SESSION AT BASELINE, THEN 2 INDIVIDUAL AND 8 WEEKLY GROUP SESSIONS FOLLOWED BY WEEKLY GENTLE YOGA AT HOME (DVD). QUESTIONNAIRES AND SALIVA SAMPLES (IE, CORTISOL) COMPLETED AT BASELINE AND 12 WEEKS POSTDIAGNOSIS. RESULTS: BOTH GROUPS REPORTED SIGNIFICANT IMPROVEMENTS IN QOL POSTINTERVENTION BUT WITH NO SIGNIFICANT DIFFERENCE BETWEEN GROUPS. EMOTIONAL WELL-BEING, MOOD-RELATED TENSION-ANXIETY, DEPRESSION-DEJECTION, AND CONFUSION-BEWILDERMENT SCORES IMPROVED FOR BOTH GROUPS, AND CORTISOL AND CORTISONE LEVELS DECREASED. LUMPECTOMIES WERE PREVALENT WITH YG (67%) AND CG (47%). YP WAS RATED AS "VERY EFFECTIVE," PROVIDING RELAXATION (85%), STRESS RELIEF (69%), AND REDUCED MUSCLE TENSION/GENERAL FEELING OF WELLNESS (EACH 62%). CONCLUSION: FEASIBILITY OF YP IMMEDIATELY AFTER BREAST CANCER DIAGNOSIS WAS GOOD. IMPROVEMENT IN EMOTIONAL WELL-BEING, ANXIETY, DEPRESSION, AND LEVELS OF CONFUSION WAS FOUND IN BOTH GROUPS. TO OUR KNOWLEDGE, THIS IS THE FIRST STUDY EXAMINING THE IMPACT OF YP IMMEDIATELY AFTER BREAST CANCER DIAGNOSIS. FURTHER RESEARCH IN THIS AREA IS WARRANTED. 2012
4 311 55 AN EXPLORATIVE STUDY OF METABOLIC RESPONSES TO MENTAL STRESS AND YOGA PRACTICES IN YOGA PRACTITIONERS, NON-YOGA PRACTITIONERS AND INDIVIDUALS WITH METABOLIC SYNDROME. BACKGROUND: STRESS PLACES A METABOLIC BURDEN ON HOMEOSTASIS AND IS LINKED TO HEIGHTENED SYMPATHETIC ACTIVITY, INCREASED ENERGY EXPENDITURE AND PATHOLOGY. THE YOGIC STATE IS A HYPOMETABOLIC STATE THAT CORRESPONDS WITH MIND-BODY COHERENCE AND REDUCED STRESS. THIS STUDY AIMED TO INVESTIGATE METABOLIC RESPONSES TO STRESS AND DIFFERENT YOGA PRACTICES IN REGULAR YOGA PRACTITIONERS (YP), NON-YOGA PRACTITIONERS (NY) AND METABOLIC SYNDROME PATIENTS (MS). METHODS: YP (N = 16), NY (N = 15) AND MS (N = 15) SUBJECTS UNDERWENT AN EXPERIMENTAL PROTOCOL THAT COMPRISED OF DIFFERENT 5-MINUTE INTERVENTIONS INCLUDING MENTAL ARITHMETIC STRESS TEST (MAST), ALTERNATE NOSTRIL BREATHING (ANB), KAPABHATI BREATHING (KB) AND MEDITATION (MED) INTERSPERSED WITH 5 MINUTES OF QUIET RESTING (NEUTRAL CONDITION (NC)). DURING THE INTERVENTION PERIODS CONTINUOUS BODY WEIGHT ADJUSTED OXYGEN CONSUMPTION (VO2ML/MIN/KG) WAS MEASURED USING OPEN CIRCUIT INDIRECT CALORIMETRY WITH A CANOPY HOOD. RESULTS: THIS IS THE FIRST STUDY TO REPORT OXYGEN CONSUMPTION (OC) IN YOGA PRACTITIONERS DURING AND AFTER MAST AND THE FIRST TO REPORT BOTH WITHIN AND BETWEEN DIFFERENT POPULATIONS. THE RESULTS WERE ANALYSED WITH SPSS 16 USING 3X9 MIXED FACTORIAL ANOVAS. THE SINGLE BETWEEN-SUBJECT FACTOR WAS GROUP (YP, NY AND MS), THE SINGLE WITHIN-SUBJECT FACTOR WAS MADE UP OF THE NINE INTERVENTION PHASES (NC1, MAST, NC2, ANB, NC3, KB, NC4, MED, NC5). THE RESULTS DEMONSTRATED THAT THE REGULAR YP GROUP HAD SIGNIFICANTLY LESS OC AND GREATER VARIABILITY IN THEIR OC ACROSS ALL PHASES COMPARED TO THE MS GROUP (P = .003) AND NY GROUP (P = .01). ALL GROUPS SIGNIFICANTLY RAISED THEIR OC DURING THE MENTAL ARITHMETIC STRESS, HOWEVER THE MS GROUP HAD A SIGNIFICANTLY BLUNTED POST-STRESS RECOVERY WHEREAS THE YP GROUP RAPIDLY RECOVERED BACK TO BASELINE LEVELS WITH POST STRESS RECOVERY BEING GREATER THAN EITHER THE NY GROUP OR MS GROUP. CONCLUSIONS: YOGA PRACTITIONERS HAVE GREATER METABOLIC VARIABILITY COMPARED TO NON-YOGA PRACTITIONERS AND METABOLIC SYNDROME PATIENTS WITH REDUCED OXYGEN REQUIREMENTS DURING RESTING CONDITIONS AND MORE RAPID POST-STRESS RECOVERY. OC IN METABOLIC SYNDROME PATIENTS DISPLAYS SIGNIFICANTLY BLUNTED POST-STRESS RECOVERY DEMONSTRATING REDUCED METABOLIC RESILIENCE. OUR RESULTS SUPPORT THE FINDINGS OF PREVIOUS RANDOMISED TRIALS THAT SUGGEST REGULAR YOGA PRACTICE MAY MITIGATE AGAINST THE EFFECTS OF METABOLIC SYNDROME. CLINICAL TRIAL NUMBER: ACTRN12614001075673; DATE OF REGISTRATION: 07/10/2014. 2014
5 1504 24 INVESTIGATION OF YOGA PRANAYAMA AND VEDIC MATHEMATICS ON MINDFULNESS, AGGRESSION AND EMOTION REGULATION. BACKGROUND: COMPETITIVE EXAMINATIONS, PARTICULARLY IN MATHEMATICS, HAVE MADE EMOTIONAL STRESS A MAJOR PROBLEM FOR PREUNIVERSITY STUDENTS, EMOTIONS LIKE AGGRESSION TOWARD FELLOW STUDENTS AND TEACHERS INCREASE. MINDFULNESS IS A QUALITY THAT REDUCES BOTH EMOTIONAL STRESS AND AGGRESSION, SO INCREASING MINDFULNESS SHOULD BE HELPFUL. AIMS: TO STUDY THE EFFECTS OF YOGA PRANAYAMA (YP) AND VEDIC MATHEMATICS (VM) ON MINDFULNESS, AGGRESSION, AND EMOTION REGULATION. METHODS: PARTICIPANTS WERE 12(TH) GRADERS ATTENDING A PREUNIVERSITY COLLEGE IN CHIKKAMAGALURU, INDIA, OF BOTH GENDERS. EXCLUSION CRITERIA INCLUDED MAJOR PSYCHOLOGICAL PROBLEMS. THREE CLASSES WERE ARBITRARILY ASSIGNED TO ONE OF THREE INTERVENTIONS, WHICH CONSISTED OF 15 DAYS EACH OF 30 MIN DAILY INSTRUCTION IN YP, GROUP 1, VM, GROUP 2, OR 30 MIN ORDINARY CLASS WORK, GROUP 3, THE CONTROL GROUP. ASSESSMENTS WERE MADE USING THE MINDFULNESS ATTENTION AWARENESS SCALE, THE NONPHYSICAL AGGRESSION SCALE FROM PITTSBURGH YOUTH STUDY, AND THE EMOTION REGULATION QUESTIONNAIRE. STATISTICAL ANALYSIS USED: SPSS 19.0. RESULTS: MINDFULNESS, AGGRESSION, AND NEGATIVE EMOTIONAL REGULATION CHANGED SIGNIFICANTLY FOR THE YP GROUP, WHILE MINDFULNESS ALONE IMPROVED SIGNIFICANTLY FOR THE VM GROUP. NO GROUP CHANGED ON POSITIVE EMOTION REGULATION. CONTROLS APPARENTLY IMPROVED ON AGGRESSION. AN INTERESTING POST HOC CORRELATION ANALYSIS IS ALSO REPORTED, AMONG OTHER THINGS DIRECTLY LINKING INCREASED MINDFULNESS TO DECREASED AGGRESSION. CONCLUSIONS: THE STUDY SHOWED POSITIVE EFFECTS OF TRADITIONAL METHODS OF DECREASING EMOTIONAL PRESSURE ON STUDENTS FACING PREUNIVERSITY MATHEMATICS EXAMINATIONS. INCREASING MINDFULNESS IS CONSIDERED A WAY OF INCREASING EMOTION REGULATION, SO THE FAILURE OF THIS STUDY TO PROVIDE EVIDENCE FOR THAT IS OF INTEREST. 2017
6 2720 29 YOGA MEDITATION PRACTITIONERS EXHIBIT GREATER GRAY MATTER VOLUME AND FEWER REPORTED COGNITIVE FAILURES: RESULTS OF A PRELIMINARY VOXEL-BASED MORPHOMETRIC ANALYSIS. HATHA YOGA TECHNIQUES, INCLUDING PHYSICAL POSTURES (ASANAS), BREATHING EXERCISES (PRANAYAMA), AND MEDITATION, INVOLVE THE PRACTICE OF MINDFULNESS. IN TURN, YOGA MEDITATION PRACTICES MAY INDUCE THE STATE OF MINDFULNESS, WHICH, WHEN EVOKED RECURRENTLY THROUGH REPEATED PRACTICE, MAY ACCRUE INTO TRAIT OR DISPOSITIONAL MINDFULNESS. PUTATIVELY, THESE CHANGES MAY BE MEDIATED BY EXPERIENCE-DEPENDENT NEUROPLASTIC CHANGES. THOUGH PRIOR STUDIES HAVE IDENTIFIED DIFFERENCES IN GRAY MATTER VOLUME (GMV) BETWEEN LONG-TERM MINDFULNESS PRACTITIONERS AND CONTROLS, NO STUDIES TO DATE HAVE REPORTED ON WHETHER YOGA MEDITATION IS ASSOCIATED WITH GMV DIFFERENCES. THE PRESENT STUDY INVESTIGATED GMV DIFFERENCES BETWEEN YOGA MEDITATION PRACTITIONERS (YMP) AND A MATCHED CONTROL GROUP (CG). THE YMP GROUP EXHIBITED GREATER GM VOLUME IN FRONTAL, LIMBIC, TEMPORAL, OCCIPITAL, AND CEREBELLAR REGIONS; WHEREAS THE CG HAD NO GREATER REGIONAL GREATER GMV. IN ADDITION, THE YMP GROUP REPORTED SIGNIFICANTLY FEWER COGNITIVE FAILURES ON THE COGNITIVE FAILURES QUESTIONNAIRE (CFQ), THE MAGNITUDE OF WHICH WAS POSITIVELY CORRELATED WITH GMV IN NUMEROUS REGIONS IDENTIFIED IN THE PRIMARY ANALYSIS. LASTLY, GMV WAS POSITIVELY CORRELATED WITH THE DURATION OF YOGA PRACTICE. RESULTS FROM THIS PRELIMINARY STUDY SUGGEST THAT HATHA YOGA PRACTICE MAY BE ASSOCIATED WITH THE PROMOTION OF NEUROPLASTIC CHANGES IN EXECUTIVE BRAIN SYSTEMS, WHICH MAY CONFER THERAPEUTIC BENEFITS THAT ACCRUE WITH REPEATED PRACTICE. 2012
7 686 35 EFFECT OF AN OFFICE WORKSITE-BASED YOGA PROGRAM ON HEART RATE VARIABILITY: A RANDOMIZED CONTROLLED TRIAL. BACKGROUND: CHRONIC WORK-RELATED STRESS IS A SIGNIFICANT AND INDEPENDENT RISK FACTOR FOR CARDIOVASCULAR AND METABOLIC DISEASES AND ASSOCIATED MORTALITY, PARTICULARLY WHEN COMPOUNDED BY A SEDENTARY WORK ENVIRONMENT. HEART RATE VARIABILITY (HRV) PROVIDES AN ESTIMATE OF PARASYMPATHETIC AND SYMPATHETIC AUTONOMIC CONTROL, AND CAN SERVE AS A MARKER OF PHYSIOLOGICAL STRESS. HATHA YOGA IS A PHYSICALLY DEMANDING PRACTICE THAT CAN HELP TO REDUCE STRESS; HOWEVER, TIME CONSTRAINTS INCURRED BY WORK AND FAMILY LIFE MAY LIMIT PARTICIPATION. THE PURPOSE OF THE PRESENT STUDY IS TO DETERMINE IF A 10-WEEK, WORKSITE-BASED YOGA PROGRAM DELIVERED DURING LUNCH HOUR CAN IMPROVE RESTING HRV AND RELATED PHYSICAL AND PSYCHOLOGICAL PARAMETERS IN SEDENTARY OFFICE WORKERS. METHODS AND DESIGN: THIS IS A PARALLEL-ARM RCT THAT WILL COMPARE THE OUTCOMES OF PARTICIPANTS ASSIGNED TO THE EXPERIMENTAL TREATMENT GROUP (YOGA) TO THOSE ASSIGNED TO A NO-TREATMENT CONTROL GROUP. PARTICIPANTS RANDOMIZED TO THE EXPERIMENTAL CONDITION WILL ENGAGE IN A 10-WEEK YOGA PROGRAM DELIVERED AT THEIR PLACE OF WORK. THE YOGA SESSIONS WILL BE GROUP-BASED, PRESCRIBED THREE TIMES PER WEEK DURING LUNCH HOUR, AND WILL BE LED BY AN EXPERIENCED YOGA INSTRUCTOR. THE PROGRAM WILL INVOLVE TEACHING BEGINNER STUDENTS SAFELY AND PROGRESSIVELY OVER 10 WEEKS A YOGA SEQUENCE THAT INCORPORATES ASANAS (POSES AND POSTURES), VINYASA (EXERCISES), PRANAYAMA (BREATHING CONTROL) AND MEDITATION. THE PRIMARY OUTCOME OF THIS STUDY IS THE HIGH FREQUENCY (HF) SPECTRAL POWER COMPONENT OF HRV (MEASURED IN ABSOLUTE UNITS; I.E. MS2), A MEASURE OF PARASYMPATHETIC AUTONOMIC CONTROL. SECONDARY OUTCOMES INCLUDE ADDITIONAL FREQUENCY AND TIME DOMAINS OF HRV, AND MEASURES OF PHYSICAL FUNCTIONING AND PSYCHOLOGICAL HEALTH STATUS. MEASURES WILL BE COLLECTED PRIOR TO AND FOLLOWING THE INTERVENTION PERIOD, AND AT 6 MONTHS FOLLOW-UP TO DETERMINE THE EFFECT OF INTERVENTION WITHDRAWAL. DISCUSSION: THIS STUDY WILL DETERMINE THE EFFECT OF WORKSITE-BASED YOGA PRACTICE ON HRV AND PHYSICAL AND PSYCHOLOGICAL HEALTH STATUS. THE FINDINGS MAY ASSIST IN IMPLEMENTING PRACTICAL INTERVENTIONS, SUCH AS YOGA, INTO THE WORKPLACE TO MITIGATE STRESS, ENHANCE HEALTH STATUS AND REDUCE THE RISK OF CARDIOVASCULAR AND METABOLIC DISEASES. TRIAL REGISTRATION: ACTRN12611000536965URL: HTTP://WWW.ANZCTR.ORG.AU/ACTRN12611000536965.ASPX. 2011
8 1273 28 FRONTAL HEMODYNAMIC RESPONSES TO HIGH FREQUENCY YOGA BREATHING IN SCHIZOPHRENIA: A FUNCTIONAL NEAR-INFRARED SPECTROSCOPY STUDY. FRONTAL HEMODYNAMIC RESPONSES TO HIGH FREQUENCY YOGA BREATHING TECHNIQUE, KAPALABHATI (KB), WERE COMPARED BETWEEN PATIENTS OF SCHIZOPHRENIA (N = 18; 14 MALES, 4 FEMALES) AND AGE, GENDER, AND EDUCATION MATCHED HEALTHY SUBJECTS (N = 18; 14 MALES, 4 FEMALES) USING FUNCTIONAL NEAR-INFRARED SPECTROSCOPY. THE DIAGNOSIS WAS CONFIRMED BY A PSYCHIATRIST USING DSM-IV. ALL PATIENTS EXCEPT ONE RECEIVED ATYPICAL ANTIPSYCHOTICS (ONE WAS ON TYPICAL). THEY HAD OBTAINED A STABILIZED STATE AS EVIDENCED BY A STEADY UNCHANGED MEDICATION FROM THEIR PSYCHIATRIST FOR THE PAST 3 MONTHS OR LONGER. THEY LEARNED KB, AMONG OTHER YOGA PROCEDURES, IN A YOGA RETREAT. KB WAS PRACTICED AT THE RATE OF 120 TIMES/MIN FOR 1 MIN. HEALTHY SUBJECTS WHO WERE FRESHLY LEARNING YOGA TOO WERE TAUGHT KB. BOTH THE GROUPS HAD NO PREVIOUS EXPOSURE TO KB PRACTICE AND THE TRAINING WAS CARRIED OUT OVER 2 WEEKS. A CHEST PRESSURE TRANSDUCER WAS USED TO MONITOR THE FREQUENCY AND INTENSITY OF THE PRACTICE OBJECTIVELY. THE FRONTAL HEMODYNAMIC RESPONSE IN TERMS OF THE OXYGENATED HEMOGLOBIN (OXYHB), DEOXYGENATED HEMOGLOBIN (DEOXYHB), AND TOTAL HEMOGLOBIN (TOTALHB) OR BLOOD VOLUME CONCENTRATION WAS TAPPED FOR 5 MIN BEFORE, 1 MIN DURING, AND FOR 5 MIN AFTER KB. THIS WAS OBTAINED IN A QUIET ROOM USING A 16-CHANNEL FUNCTIONAL NEAR-INFRARED SYSTEM (FNIR100-ACK-W, BIOPAC SYSTEMS, INC., USA). THE AVERAGE OF THE EIGHT CHANNELS FOR EACH SIDE (RIGHT AND LEFT FRONTALS) WAS OBTAINED FOR THE THREE SESSIONS. THE CHANGES IN THE LEVELS OF OXYHB, DEOXYHB, AND BLOOD VOLUME FOR THE THREE SESSIONS WERE COMPARED BETWEEN THE TWO GROUPS USING INDEPENDENT SAMPLES T-TEST. WITHIN GROUP COMPARISON SHOWED THAT THE INCREASE IN BILATERAL OXYHB AND TOTALHB FROM THE BASELINE WAS HIGHLY SIGNIFICANT IN HEALTHY CONTROLS DURING KB (RIGHT OXYHB, P = 0.00; LEFT OXYHB, P = 0.00 AND RIGHT TOTALHB, P = 0.01; LEFT TOTALHB, P = 0.00), WHEREAS SCHIZOPHRENIA PATIENTS DID NOT SHOW ANY SIGNIFICANT CHANGES IN THE SAME ON BOTH THE SIDES. ON THE OTHER HAND, SCHIZOPHRENIA PATIENTS SHOWED SIGNIFICANT REDUCTION IN DEOXYHB IN THE RIGHT PRE-FRONTAL CORTEX (RIGHT DEOXYHB, P = 0.00). COMPARISON BETWEEN THE GROUPS SHOWED THAT SCHIZOPHRENIA PATIENTS HAVE REDUCED BILATERAL PRE-FRONTAL ACTIVATION (RIGHT OXYHB, P = 0.01; LEFT OXYHB, P = 0.03 AND RIGHT TOTAL HB, P = 0.03; LEFT TOTAL HB, P = 0.04) DURING KB AS COMPARED TO HEALTHY CONTROLS. THIS HYPO-FRONTALITY OF SCHIZOPHRENIA PATIENTS IN RESPONSE TO KB MAY BE USED CLINICALLY TO SUPPORT THE DIAGNOSIS OF SCHIZOPHRENIA IN FUTURE. 2014
9 1668 34 NEUROCOGNITIVE CORRELATES OF THE EFFECTS OF YOGA MEDITATION PRACTICE ON EMOTION AND COGNITION: A PILOT STUDY. MINDFULNESS MEDITATION INVOLVES ATTENDING TO EMOTIONS WITHOUT COGNITIVE FIXATION OF EMOTIONAL EXPERIENCE. OVER TIME, THIS PRACTICE IS HELD TO PROMOTE ALTERATIONS IN TRAIT AFFECTIVITY AND ATTENTIONAL CONTROL WITH RESULTANT EFFECTS ON WELL-BEING AND COGNITION. HOWEVER, RELATIVELY LITTLE IS KNOWN REGARDING THE NEURAL SUBSTRATES OF MEDITATION EFFECTS ON EMOTION AND COGNITION. THE PRESENT STUDY INVESTIGATED THE NEUROCOGNITIVE CORRELATES OF EMOTION INTERFERENCE ON COGNITION IN YOGA PRACTITIONERS AND A MATCHED CONTROL GROUP (CG) UNDERWENT FMRI WHILE PERFORMING AN EVENT-RELATED AFFECTIVE STROOP TASK. THE TASK INCLUDES IMAGE VIEWING TRIALS AND STROOP TRIALS BRACKETED BY NEUTRAL OR NEGATIVE EMOTIONAL DISTRACTORS. DURING IMAGE VIEWING TRIALS, YOGA PRACTITIONERS EXHIBITED LESS REACTIVITY IN RIGHT DORSOLATERAL PREFRONTAL CORTEX (DLPFC) TO NEGATIVE AS COMPARED TO NEUTRAL IMAGES; WHEREAS THE CG HAD THE OPPOSITE PATTERN. A MAIN EFFECT OF VALENCE (NEGATIVE > NEUTRAL) WAS OBSERVED IN LIMBIC REGIONS (E.G., AMYGDALA), OF WHICH THE MAGNITUDE WAS INVERSELY RELATED TO DLPFC ACTIVATION. EXPLORATORY ANALYSES REVEALED THAT THE MAGNITUDE OF AMYGDALA ACTIVATION PREDICTED DECREASED SELF-REPORTED POSITIVE AFFECT IN THE CG, BUT NOT AMONG YOGA PRACTITIONERS. DURING STROOP TRIALS, YOGA PRACTITIONERS HAD GREATER ACTIVATION IN VENTROLATERAL PREFRONTAL CORTEX (VLPFC) DURING STROOP TRIALS WHEN NEGATIVE, COMPARED TO NEUTRAL, EMOTIONAL DISTRACTOR WERE PRESENTED; THE CG EXHIBITED THE OPPOSITE PATTERN. TAKEN TOGETHER, THESE DATA SUGGEST THAT THOUGH YOGA PRACTITIONERS EXHIBIT LIMBIC REACTIVITY TO NEGATIVE EMOTIONAL STIMULI, SUCH REACTIVITY DOES NOT HAVE DOWNSTREAM EFFECTS ON LATER MOOD STATE. THIS UNCOUPLING OF VIEWING NEGATIVE EMOTIONAL IMAGES AND AFFECT AMONG YOGA PRACTITIONERS MAY BE OCCASIONED BY THEIR SELECTIVE IMPLEMENTATION OF FRONTAL EXECUTIVE-DEPENDENT STRATEGIES TO REDUCE EMOTIONAL INTERFERENCE DURING COMPETING COGNITIVE DEMANDS AND NOT DURING EMOTIONAL PROCESSING PER SE. 2012
10 687 37 EFFECT OF AN OFFICE WORKSITE-BASED YOGA PROGRAM ON HEART RATE VARIABILITY: OUTCOMES OF A RANDOMIZED CONTROLLED TRIAL. BACKGROUND: CHRONIC WORK-RELATED STRESS IS AN INDEPENDENT RISK FACTOR FOR CARDIOMETABOLIC DISEASES AND ASSOCIATED MORTALITY, PARTICULARLY WHEN COMPOUNDED BY A SEDENTARY WORK ENVIRONMENT. THE PURPOSE OF THIS STUDY WAS TO DETERMINE IF AN OFFICE WORKSITE-BASED HATHA YOGA PROGRAM COULD IMPROVE PHYSIOLOGICAL STRESS, EVALUATED VIA HEART RATE VARIABILITY (HRV), AND ASSOCIATED HEALTH-RELATED OUTCOMES IN A COHORT OF OFFICE WORKERS. METHODS: THIRTY-SEVEN ADULTS EMPLOYED IN UNIVERSITY-BASED OFFICE POSITIONS WERE RANDOMIZED UPON THE COMPLETION OF BASELINE TESTING TO AN EXPERIMENTAL OR CONTROL GROUP. THE EXPERIMENTAL GROUP COMPLETED A 10-WEEK YOGA PROGRAM PRESCRIBED THREE SESSIONS PER WEEK DURING LUNCH HOUR (50 MIN PER SESSION). AN EXPERIENCED INSTRUCTOR LED THE SESSIONS, WHICH EMPHASIZED ASANAS (POSTURES) AND VINYASA (EXERCISES). THE PRIMARY OUTCOME WAS THE HIGH FREQUENCY (HF) POWER COMPONENT OF HRV. SECONDARY OUTCOMES INCLUDED ADDITIONAL HRV PARAMETERS, MUSCULOSKELETAL FITNESS (I.E. PUSH-UP, SIDE-BRIDGE, AND SIT & REACH TESTS) AND PSYCHOLOGICAL INDICES (I.E. STATE AND TRAIT ANXIETY, QUALITY OF LIFE AND JOB SATISFACTION). RESULTS: ALL MEASURES OF HRV FAILED TO CHANGE IN THE EXPERIMENTAL GROUP VERSUS THE CONTROL GROUP, EXCEPT THAT THE EXPERIMENTAL GROUP SIGNIFICANTLY INCREASED LF:HF (P = 0.04) AND REDUCED PNN50 (P = 0.04) VERSUS CONTROL, CONTRARY TO OUR HYPOTHESES. FLEXIBILITY, EVALUATED VIA SIT & REACH TEST INCREASED IN THE EXPERIMENTAL GROUP VERSUS THE CONTROL GROUP (P < 0.001). NO OTHER ADAPTATIONS WERE NOTED. POST HOC ANALYSIS COMPARING PARTICIPANTS WHO COMPLETED >/=70% OF YOGA SESSIONS (N = 11) TO CONTROL (N = 19) YIELDED THE SAME FINDINGS, EXCEPT THAT THE HIGH ADHERERS ALSO REDUCED STATE ANXIETY (P = 0.02) AND RMSSD (P = 0.05), AND TENDED TO IMPROVE THE PUSH-UP TEST (P = 0.07) VERSUS CONTROL. CONCLUSIONS: A 10-WEEK HATHA YOGA INTERVENTION DELIVERED AT THE OFFICE WORKSITE DURING LUNCH HOUR DID NOT IMPROVE HF POWER OR OTHER HRV PARAMETERS. HOWEVER, IMPROVEMENTS IN FLEXIBILITY, STATE ANXIETY AND MUSCULOSKELETAL FITNESS WERE NOTED WITH HIGH ADHERENCE. FUTURE INVESTIGATIONS SHOULD INCORPORATE STRATEGIES TO PROMOTE ADHERENCE, INVOLVE MORE FREQUENT AND LONGER DURATIONS OF YOGA TRAINING, AND ENROL COHORTS WHO SUFFER FROM HIGHER LEVELS OF WORK-RELATED STRESS. TRIAL REGISTRATION: ACTRN12611000536965. 2013
11 743 32 EFFECT OF RESTORATIVE YOGA VS. STRETCHING ON DIURNAL CORTISOL DYNAMICS AND PSYCHOSOCIAL OUTCOMES IN INDIVIDUALS WITH THE METABOLIC SYNDROME: THE PRYSMS RANDOMIZED CONTROLLED TRIAL. PURPOSE: CHRONIC STIMULATION AND DYSREGULATION OF THE NEUROENDOCRINE SYSTEM BY STRESS MAY CAUSE METABOLIC ABNORMALITIES. WE ESTIMATED HOW MUCH CORTISOL AND PSYCHOSOCIAL OUTCOMES IMPROVED WITH A RESTORATIVE YOGA (RELAXATION) VERSUS A LOW IMPACT STRETCHING INTERVENTION FOR INDIVIDUALS WITH THE METABOLIC SYNDROME. METHODS: WE CONDUCTED A 1-YEAR MULTI-CENTER RANDOMIZED CONTROLLED TRIAL (6-MONTH INTERVENTION AND 6-MONTH MAINTENANCE PHASE) OF RESTORATIVE YOGA VS. STRETCHING. PARTICIPANTS COMPLETED SURVEYS TO ASSESS DEPRESSION, SOCIAL SUPPORT, POSITIVE AFFECT, AND STRESS AT BASELINE, 6 MONTHS AND 12 MONTHS. FOR EACH ASSESSMENT, WE COLLECTED SALIVA AT FOUR POINTS DAILY FOR THREE DAYS AND COLLECTED RESPONSE TO DEXAMETHASONE ON THE FOURTH DAY FOR ANALYSIS OF DIURNAL CORTISOL DYNAMICS. WE ANALYZED OUR DATA USING MULTIVARIATE REGRESSION MODELS, CONTROLLING FOR STUDY SITE, MEDICATIONS (ANTIDEPRESSANTS, HORMONE THERAPY), BODY MASS INDEX, AND BASELINE CORTISOL VALUES. RESULTS: PSYCHOSOCIAL OUTCOME MEASURES WERE AVAILABLE FOR 171 STUDY PARTICIPANTS AT BASELINE, 140 AT 6 MONTHS, AND 132 AT 1 YEAR. COMPLETE CORTISOL DATA WERE AVAILABLE FOR 136 OF 171 STUDY PARTICIPANTS (72 IN RESTORATIVE YOGA AND 64 IN STRETCHING) AND WERE ONLY AVAILABLE AT BASELINE AND 6 MONTHS. AT 6 MONTHS, THE STRETCHING GROUP HAD DECREASED CORTISOL AT WAKING AND BEDTIME COMPARED TO THE RESTORATIVE YOGA GROUP. THE PATTERN OF CHANGES IN STRESS MIRRORED THIS IMPROVEMENT, WITH THE STRETCHING GROUP SHOWING REDUCTIONS IN CHRONIC STRESS SEVERITY AND PERSEVERATIVE THOUGHTS ABOUT THEIR STRESS. PERCEIVED STRESS DECREASED BY 1.5 POINTS (-0.4; 3.3, P=0.11) AT 6 MONTHS, AND BY 2.0 POINTS (0.1; 3.9, P=0.04) AT 1 YEAR IN THE STRETCHING COMPARED TO RESTORATIVE YOGA GROUPS. POST HOC ANALYSES SUGGEST THAT IN THE STRETCHING GROUP ONLY, PERCEIVED INCREASES IN SOCIAL SUPPORT (PARTICULARLY FEELINGS OF BELONGING), BUT NOT CHANGES IN STRESS WERE RELATED TO IMPROVED CORTISOL DYNAMICS. CONCLUSIONS: WE FOUND SIGNIFICANT DECREASES IN SALIVARY CORTISOL, CHRONIC STRESS SEVERITY, AND STRESS PERCEPTION IN THE STRETCHING GROUP COMPARED TO THE RESTORATIVE YOGA GROUP. GROUP SUPPORT DURING THE INTERACTIVE STRETCH CLASSES MAY HAVE CONTRIBUTED TO THESE CHANGES. 2014
12 1089 29 EFFECTS OF YOGA ON THE AUTONOMIC NERVOUS SYSTEM, GAMMA-AMINOBUTYRIC-ACID, AND ALLOSTASIS IN EPILEPSY, DEPRESSION, AND POST-TRAUMATIC STRESS DISORDER. A THEORY IS PROPOSED TO EXPLAIN THE BENEFITS OF YOGA PRACTICES IN DIVERSE, FREQUENTLY COMORBID MEDICAL CONDITIONS BASED ON THE CONCEPT THAT YOGA PRACTICES REDUCE ALLOSTATIC LOAD IN STRESS RESPONSE SYSTEMS SUCH THAT OPTIMAL HOMEOSTASIS IS RESTORED. IT IS HYPOTHESIZED THAT STRESS INDUCES (1) IMBALANCE OF THE AUTONOMIC NERVOUS SYSTEM (ANS) WITH DECREASED PARASYMPATHETIC NERVOUS SYSTEM (PNS) AND INCREASED SYMPATHETIC NERVOUS SYSTEM (SNS) ACTIVITY, (2) UNDERACTIVITY OF THE GAMMA AMINO-BUTYRIC ACID (GABA) SYSTEM, THE PRIMARY INHIBITORY NEUROTRANSMITTER SYSTEM, AND (3) INCREASED ALLOSTATIC LOAD. IT IS FURTHER HYPOTHESIZED THAT YOGA-BASED PRACTICES (4) CORRECT UNDERACTIVITY OF THE PNS AND GABA SYSTEMS IN PART THROUGH STIMULATION OF THE VAGUS NERVES, THE MAIN PERIPHERAL PATHWAY OF THE PNS, AND (5) REDUCE ALLOSTATIC LOAD. DEPRESSION, EPILEPSY, POST TRAUMATIC STRESS DISORDER (PTSD), AND CHRONIC PAIN EXEMPLIFY MEDICAL CONDITIONS THAT ARE EXACERBATED BY STRESS, HAVE LOW HEART RATE VARIABILITY (HRV) AND LOW GABAERGIC ACTIVITY, RESPOND TO PHARMACOLOGIC AGENTS THAT INCREASE ACTIVITY OF THE GABA SYSTEM, AND SHOW SYMPTOM IMPROVEMENT IN RESPONSE TO YOGA-BASED INTERVENTIONS. THE OBSERVATION THAT TREATMENT RESISTANT CASES OF EPILEPSY AND DEPRESSION RESPOND TO VAGAL NERVE STIMULATION CORROBORATES THE NEED TO CORRECT PNS UNDERACTIVITY AS PART OF A SUCCESSFUL TREATMENT PLAN IN SOME CASES. ACCORDING TO THE PROPOSED THEORY, THE DECREASED PNS AND GABAERGIC ACTIVITY THAT UNDERLIES STRESS-RELATED DISORDERS CAN BE CORRECTED BY YOGA PRACTICES RESULTING IN AMELIORATION OF DISEASE SYMPTOMS. THIS HAS FAR-REACHING IMPLICATIONS FOR THE INTEGRATION OF YOGA-BASED PRACTICES IN THE TREATMENT OF A BROAD ARRAY OF DISORDERS EXACERBATED BY STRESS. 2012
13 1215 34 EXPLORING THE EFFECTS OF YOGA THERAPY ON HEART RATE VARIABILITY AND PATIENT-REPORTED OUTCOMES AFTER CANCER TREATMENT: A STUDY PROTOCOL. BACKGROUND: FOLLOWING CANCER TREATMENT, ADULTS COMMONLY REPORT WORSENED PATIENT-REPORTED OUTCOMES (PROS) SUCH AS ANXIETY, STRESS, DEPRESSION, PERSISTENT AND UPSETTING COGNITIVE COMPLAINTS, UNRELENTING FATIGUE, AND REDUCED QUALITY OF LIFE. POORER PROS ARE ASSOCIATED WITH DISRUPTED AUTONOMIC NERVOUS SYSTEM FUNCTIONING AS MEASURED BY HEART RATE VARIABILITY (HRV), BOTH OF WHICH HAVE BEEN ASSOCIATED WITH GREATER MORBIDITY AND MORTALITY. INTERVENTIONS TO IMPROVE HRV AND PROS AMONG ADULTS FOLLOWING CANCER TREATMENT ARE NEEDED. YOGA THERAPY HOLDS PROMISE AS AN INTERVENTION TO IMPROVE HRV AND PROS. THEREFORE, WE CONDUCTED A SINGLE-SUBJECT EXPLORATORY EXPERIMENTAL STUDY TO INVESTIGATE THE EFFECTS OF YOGA THERAPY ON HRV AND SPECIFIC PROS (IE, CANCER-RELATED FATIGUE, ANXIETY, COGNITIVE FUNCTION, DEPRESSION, STRESS, QUALITY OF LIFE) IN ADULTS TREATED FOR CANCER. TO REDUCE PUBLICATION BIAS, IMPROVE REPRODUCIBILITY, AND SERVE AS A REFERENCE FOR FORTHCOMING REPORTING OF STUDY RESULTS, WE PRESENT THE STUDY PROTOCOL FOR THIS STUDY HEREIN. METHODS: PARTICIPANTS WERE ADULTS WHO COMPLETED CANCER TREATMENT THAT WERE RECRUITED FROM THE OTTAWA INTEGRATIVE CANCER CENTRE. CONSENTING AND ELIGIBLE PARTICIPANTS RECEIVED ONE 1:1 YOGA THERAPY SESSION (IE, 1 PARTICIPANT, 1 YOGA THERAPIST) AND 6 WEEKLY GROUP-BASED YOGA THERAPY SESSIONS (IE, 2-3 PARTICIPANTS, 1 YOGA THERAPIST). PARTICIPANTS COMPLETED ASSESSMENTS 7 TIMES: 3 TIMES PRIOR TO THE PROGRAM (IE, -6 WEEKS, -3 WEEKS, IMMEDIATELY PRIOR TO THE 1:1 YOGA THERAPY SESSION), IMMEDIATELY FOLLOWING THE 1:1 YOGA THERAPY SESSION, PRIOR TO THE FIRST GROUP-BASED YOGA THERAPY SESSION, AFTER THE LAST GROUP-BASED YOGA THERAPY SESSION, AND AT A 6-WEEK FOLLOW-UP. HIERARCHICAL LINEAR MODELING WILL BE USED TO TEST THE AVERAGE EFFECTS OF THE YOGA THERAPY PROGRAM ACROSS PARTICIPANTS. DISCUSSION: THIS STUDY WILL EXPLORE SEVERAL NOVEL HYPOTHESES, INCLUDING WHETHER YOGA THERAPY CAN IMPROVE HRV AND/OR SPECIFIC PROS AMONG ADULTS TREATED FOR CANCER ACUTELY (IE, DURING A 1:1 YOGA THERAPY SESSION) AND/OR THROUGH REPEATED EXPOSURE (IE, AFTER COMPLETING 6 WEEKS OF GROUP-BASED YOGA THERAPY). ALTHOUGH THE FINDINGS WILL REQUIRE CONFIRMATION OR REFUTATION IN FUTURE TRIALS, THEY MAY PROVIDE INITIAL EVIDENCE THAT YT MAY BENEFIT ADULTS TREATED FOR CANCER. TRIAL REGISTRATION: ISRCTN REGISTRY, ISRCTN64763228. REGISTERED ON DECEMBER 12, 2021. THIS TRIAL WAS REGISTERED RETROSPECTIVELY. URL OF TRIAL REGISTRY RECORD: HTTPS://WWW.ISRCTN.COM/ISRCTN64763228. 2022
14 1811 36 PROFILE OF MOOD STATES AND STRESS-RELATED BIOCHEMICAL INDICES IN LONG-TERM YOGA PRACTITIONERS. BACKGROUND: PREVIOUS STUDIES HAVE SHOWN THE SHORT-TERM OR INTERMEDIATE-TERM PRACTICE OF YOGA TO BE USEFUL FOR AMELIORATING SEVERAL MENTAL DISORDERS AND PSYCHOSOMATIC DISORDERS. HOWEVER, LITTLE IS KNOWN ABOUT THE LONG-TERM INFLUENCES OF YOGA ON THE MENTAL STATE OR STRESS-RELATED BIOCHEMICAL INDICES. IF YOGA TRAINING HAS A STRESS-REDUCTION EFFECT AND ALSO IMPROVES AN INDIVIDUAL'S MENTAL STATES FOR A LONG TIME, LONG-TERM YOGA PRACTITIONERS MAY HAVE A BETTER MENTAL STATE AND LOWER STRESS-RELATED BIOCHEMICAL INDICES IN COMPARISON TO NON-EXPERIENCED PARTICIPANTS. THIS STUDY SIMULTANEOUSLY EXAMINED THE DIFFERENCES IN MENTAL STATES AND URINARY STRESS-RELATED BIOCHEMICAL INDICES BETWEEN LONG-TERM YOGA PRACTITIONERS AND NON-EXPERIENCED PARTICIPANTS. METHODS: THE PARTICIPANTS WERE 38 HEALTHY FEMALES WITH MORE THAN 2 YEARS OF EXPERIENCE WITH YOGA (LONG-TERM YOGA GROUP) AND 37 AGE-MATCHED HEALTHY FEMALES WHO HAD NOT PARTICIPATED IN YOGA (CONTROL GROUP). THEIR MENTAL STATES WERE ASSESSED USING THE PROFILE OF MOOD STATES (POMS) QUESTIONNAIRE. THE LEVEL OF CORTISOL, 8-HYDROXYDEOXYGUANOSINE (8-OHDG) AND BIOPYRRIN IN URINE WERE USED AS STRESS-RELATED BIOCHEMICAL INDICES. RESULTS: THE AVERAGE SELF-RATED MENTAL DISTURBANCE, TENSION-ANXIETY, ANGER-HOSTILITY, AND FATIGUE SCORES OF THE LONG-TERM YOGA GROUP WERE LOWER THAN THOSE OF THE CONTROL GROUP. THERE WAS A TREND TOWARD A HIGHER VIGOR SCORE IN THE LONG-TERM YOGA GROUP THAN THAT IN THE CONTROL GROUP. THERE WERE NO SIGNIFICANT DIFFERENCES IN THE SCORES FOR DEPRESSION AND CONFUSION IN THE POMS BETWEEN THE TWO GROUPS. THE URINE 8-OHDG CONCENTRATION SHOWED A TREND TOWARD TO BEING LOWER IN THE LONG-TERM YOGA GROUP IN COMPARISON TO THE CONTROL GROUP. THERE WERE NO SIGNIFICANT DIFFERENCES IN THE LEVELS OF URINE BIOPYRRIN OR CORTISOL. CONCLUSIONS: THE PRESENT FINDINGS SUGGEST THAT LONG-TERM YOGA TRAINING CAN REDUCE THE SCORES RELATED TO MENTAL HEALTH INDICATORS SUCH AS SELF-RATED ANXIETY, ANGER, AND FATIGUE. 2011
15 724 38 EFFECT OF LAUGHTER YOGA ON MOOD AND HEART RATE VARIABILITY IN PATIENTS AWAITING ORGAN TRANSPLANTATION: A PILOT STUDY. CONTEXT: RESEARCH SHOWS THAT LAUGHTER HAS MYRIAD HEALTH BENEFITS, YET THE MEDICAL COMMUNITY HAS NOT IMPLEMENTED IT FORMALLY AS A TREATMENT. PATIENTS AWAITING ORGAN TRANSPLANTATION HAVE SIGNIFICANT PHYSICAL DISABILITIES AND ARE AT RISK FOR PSYCHOLOGICAL DISTRESS. ATTENUATED HEART RATE VARIABILITY (HRV) IS A RISK FACTOR FOR A NEGATIVE LONG-TERM OUTCOME IN SOME PATIENTS. OBJECTIVE: THE STUDY INTENDED TO EVALUATE THE CLINICAL UTILITY OF LAUGHTER YOGA IN IMPROVING PSYCHOLOGICAL AND PHYSIOLOGICAL MEASURES IN OUTPATIENTS AWAITING ORGAN TRANSPLANTATION. POSITIVE RESULTS WOULD INDICATE PROMISING AREAS TO PURSUE IN A FOLLOW-UP STUDY. DESIGN: SIX PARTICIPANTS MET FOR 10 SESSIONS OVER 4 WEEKS. THE RESEARCH TEAM MEASURED EACH PARTICIPANT'S HEART RATE, HRV, BLOOD PRESSURE (BP), AND IMMEDIATE MOOD BEFORE AND AFTER THE LAUGHTER AND CONTROL INTERVENTIONS. THE TEAM ASSESSED PARTICIPANTS' LONGER-TERM MOOD (ANXIETY AND DEPRESSION) AT THE STUDY'S INITIATION, AFTER A NO-TREATMENT CONTROL WEEK, AND AT THE END OF THE STUDY. SETTING: THE STUDY OCCURRED AT THE DEPARTMENT OF SURGERY AND MEDICINE AT THE UNIVERSITY OF ARIZONA HEALTH SCIENCES CENTER, TUCSON. PARTICIPANTS: PARTICIPANTS WERE PATIENTS AWAITING TRANSPLANTS (THREE HEART AND THREE LUNG), TWO WOMEN AND FOUR MEN (AGES 51-69 Y). PARTICIPANTS HAD RECEIVED NO MAJOR SURGERY IN THE 3 MONTHS PRIOR TO THE INTERVENTION, DID NOT HAVE A HERNIA OR UNCONTROLLED HYPERTENSION, AND DID NOT FALL INTO THE NEW YORK HEART ASSOCIATION FUNCTION CLASS 4. INTERVENTION: THE 20-MINUTE LAUGHTER INTERVENTION INVOLVED BREATHING AND STRETCHING EXERCISES, SIMULATED LAUGHTER (IE, UNCONDITIONAL LAUGHTER THAT IS NOT CONTINGENT ON THE ENVIRONMENT), CHANTING, CLAPPING, AND A MEDITATION. THE 20-MINUTE CONTROL INTERVENTION INVOLVED THE STUDY'S PERSONNEL DISCUSSING HEALTH AND STUDY-RELATED TOPICS WITH THE PARTICIPANTS. OUTCOME MEASURES: THE RESEARCH TEAM MEASURED BP, HEART RATE, AND HRV AND ADMINISTERED THE PROFILE OF MOOD STATES, BECK ANXIETY INVENTORY, AND BECK DEPRESSION INVENTORY-II TO EVALUATE IMMEDIATE AND LONGER-TERM MOOD. THE TEAM HAD PLANNED QUANTITATIVE STATISTICAL ANALYSIS OF THE DATA AT THE STUDY'S INITIATION BUT DID NOT COMPLETE IT BECAUSE THE NUMBER OF ENROLLED PARTICIPANTS WAS TOO LOW FOR THE ANALYSIS TO BE MEANINGFUL. THE TEAM VISUALLY EXAMINED THE DATA, HOWEVER, FOR TRENDS THAT WOULD INDICATE AREAS TO EXAMINE FURTHER IN A FOLLOW-UP STUDY. RESULTS: PARTICIPANTS SHOWED IMPROVED IMMEDIATE MOOD (VIGOR-ACTIVITY AND FRIENDLINESS) AND INCREASED HRV AFTER THE LAUGHTER INTERVENTION. BOTH THE LAUGHTER AND CONTROL INTERVENTIONS APPEARED TO IMPROVE LONGER-TERM ANXIETY. TWO PARTICIPANTS AWAITING A LUNG TRANSPLANT DROPPED OUT OF THE STUDY, AND NO ADVERSE EVENTS OCCURRED. CONCLUSION: THIS PILOT STUDY SUGGESTS THAT LAUGHTER YOGA MAY IMPROVE HRV AND SOME ASPECTS OF MOOD, AND THIS TOPIC WARRANTS FURTHER RESEARCH. 2012
16 629 41 DIFFERENCES IN BRAIN STRUCTURE AND FUNCTION AMONG YOGA PRACTITIONERS AND CONTROLS. BACKGROUND: YOGA IS A MIND-BODY BASED PHYSICAL ACTIVITY THAT HAS DEMONSTRATED A VARIETY OF PHYSIOLOGICAL, PSYCHOLOGICAL AND COGNITIVE HEALTH BENEFITS. ALTHOUGH YOGA PRACTICE HAS SHOWN TO IMPROVE COGNITIVE PERFORMANCE, FEW STUDIES HAVE EXAMINED THE UNDERLYING NEUROLOGICAL CORRELATES. OBJECTIVE: THE CURRENT STUDY AIMED TO DETERMINE THE DIFFERENCES IN GRAY MATTER VOLUME OF THE HIPPOCAMPUS, THALAMUS AND CAUDATE NUCLEUS AND BRAIN ACTIVATION DURING THE STERNBERG WORKING MEMORY TASK. METHOD: PARTICIPANTS WERE 13 EXPERIENCED YOGA PRACTITIONERS (MEAN AGE = 35.8), DEFINED AS HAVING MORE THAN 3 YEARS OF REGULAR YOGA PRACTICE, AND 13 AGE- AND SEX-MATCHED CONTROLS (MEAN AGE = 35.7). ALL PARTICIPANTS COMPLETED A 6-MIN WALK TEST TO ASSESS FITNESS, PSYCHOSOCIAL AND DEMOGRAPHIC QUESTIONNAIRES; AND UNDERWENT MAGNETIC RESONANCE IMAGING TO ASSESS GRAY MATTER VOLUME AND BRAIN ACTIVATION. RESULTS: THERE WERE NO GROUP DIFFERENCES ON DEMOGRAPHIC MEASURES OF INCOME, EDUCATION AND ON ESTIMATED VO2MAX OR PHYSICAL ACTIVITY LEVELS. GRAY MATTER VOLUME DIFFERENCES WERE OBSERVED IN THE LEFT HIPPOCAMPUS, SHOWING GREATER VOLUME IN EXPERIENCED YOGA PRACTITIONERS COMPARED TO CONTROLS (P = 0.017). THE FUNCTIONAL MRI RESULTS REVEALED LESS ACTIVATION IN THE DORSOLATERAL PREFRONTAL CORTEX IN YOGA PRACTITIONERS COMPARED TO CONTROLS DURING THE ENCODING PHASE OF THE STERNBERG TASK (P < 0.05). REACTION TIME AND ACCURACY ON THE TASK DID NOT DIFFER BETWEEN THE GROUPS. CONCLUSIONS: OUR RESULTS SUGGEST AN ASSOCIATION BETWEEN REGULAR LONG-TERM YOGA PRACTICE AND DIFFERENTIAL STRUCTURE AND FUNCTION OF SPECIFIC BRAIN REGIONS INVOLVED IN EXECUTIVE FUNCTION, SPECIFICALLY WORKING MEMORY, WHICH HAS PREVIOUSLY SHOWN TO IMPROVE WITH YOGA PRACTICE. FUTURE STUDIES NEED TO EXAMINE INTERVENTION EFFECTS OF YOGA AND EXPLORE ITS POTENTIAL TO MAINTAIN AND IMPROVE COGNITIVE HEALTH ACROSS THE LIFESPAN THROUGH LONGITUDINAL AND INTERVENTION STUDIES. 2018
17 1334 22 HOW DOES EXERCISE IMPROVE IMPLICIT EMOTION REGULATION ABILITY: PRELIMINARY EVIDENCE OF MIND-BODY EXERCISE INTERVENTION COMBINED WITH AEROBIC JOGGING AND MINDFULNESS-BASED YOGA. PURPOSE: THE PRIMARY AIM OF THE PRESENT STUDY IS TO EXAMINE THE EFFECT OF 8-WEEK MIND-BODY EXERCISE INTERVENTION COMBINING AEROBIC JOGGING AND MINDFULNESS-BASED YOGA ON IMPLICIT EMOTION REGULATION ABILITY. THE SECONDARY AIM IS TO EXPLORE THE SPECIFIC POTENTIAL PATHWAYS BY WHICH THE MIND-BODY EXERCISE INTERVENTION FOSTERS IMPLICIT EMOTION REGULATION. THIS MAY HELP US TO UNDERSTAND HOW THE KEY COMPONENTS OF EXERCISE INTERVENTION CONTRIBUTE TO EMOTIONAL BENEFITS. METHODS: SIXTY PARTICIPANTS WERE RANDOMLY ALLOCATED TO ONE OF TWO PARALLEL GROUPS: (1) THE INTERVENTION GROUP (N = 29) AND (2) THE WAITLIST CONTROL GROUP (N = 31). PARTICIPANTS WERE ASKED TO FILL OUT SCALES MEASURING MINDFULNESS AND INSTRUCTED TO COMPLETE AN EMOTION REGULATION TASK TO ASSESS IMPLICIT EMOTION REGULATION ABILITY AS WELL AS THE PWC 170 TEST TO EVALUATE AEROBIC FITNESS BEFORE AND AFTER THE INTERVENTION. RESULTS: THE RESULTS OF THE TWO-WAY REPEATED ANOVA REVEALED THAT 8 WEEKS OF INTERVENTION IMPROVED IMPLICIT EMOTION REGULATION, MINDFULNESS, AND AEROBIC FITNESS LEVELS. PATH ANALYSIS SHOWED THAT ONLY IMPROVED AEROBIC FITNESS MEDIATED THE INTERVENTION EFFECT ON IMPLICIT EMOTION REGULATION ABILITY, CONTROLLING FOR CHANGE IN NEGATIVE AFFECT. NOTABLY, THE RELATIONSHIP BETWEEN THE EFFECTS ON IMPLICIT EMOTION REGULATION ABILITY AND AEROBIC FITNESS WAS MODERATED BY IMPROVED MINDFULNESS. CONCLUSION: EIGHT WEEKS OF MIND-BODY EXERCISE INTERVENTION IMPROVES IMPLICIT EMOTION REGULATION ABILITY. THE AEROBIC FITNESS MAY BE AN ESSENTIAL PATHWAY WHICH MEDIATES THE EFFICACY ON IMPLICIT EMOTION REGULATION ABILITY. FURTHERMORE, DIFFERENT COMPONENTS, SUCH AS AEROBIC FITNESS AND MINDFULNESS, MAY INTERACTIVELY CONTRIBUTE TO SUCH EMOTIONAL BENEFITS. 2019
18 1192 33 EXAMINING A THERAPEUTIC YOGA PROGRAM FOR PROSTATE CANCER SURVIVORS. BACKGROUND: IN THE EARLIER STAGES OF PROSTATE CANCER, EFFECTIVE TREATMENTS HAVE CREATED A NEED FOR RESEARCH TO FOCUS ON PRACTICES THAT MAY IMPROVE QUALITY OF LIFE THROUGHOUT SURVIVORSHIP. PHYSICAL ACTIVITY IS A SIGNIFICANT SUPPORTIVE CARE MANAGEMENT STRATEGY FOR PROSTATE CANCER SURVIVORS, THOUGH THE OPTIMAL MODALITY IS NOT YET UNDERSTOOD. HYPOTHESES: THE AUTHORS HYPOTHESIZED THAT YOGA WOULD BE A FEASIBLE PHYSICAL ACTIVITY OPTION FOR PROSTATE CANCER SURVIVORS AND THEIR SUPPORT PERSONS AND THAT THE INCORPORATION OF SOCIAL SUPPORT WOULD INCREASE PHYSICAL ACTIVITY ADHERENCE. METHODS: THIS 14-WEEK FEASIBILITY STUDY INVOLVED A 7-WEEK CLASS-BASED YOGA PROGRAM (ADHERENCE PHASE), FOLLOWED BY 7 WEEKS OF SELF-SELECTED PHYSICAL ACTIVITY (MAINTENANCE PHASE). DEMOGRAPHIC INFORMATION, PHYSICAL ACTIVITY BEHAVIOR, QUALITY OF LIFE, FATIGUE, STRESS, MOOD, AND FITNESS VARIABLES WERE ASSESSED AT 3 TIME POINTS. PROSTATE CANCER SURVIVORS' PERCEIVED SOCIAL SUPPORT WAS RATED DURING YOGA AND AFTER YOGA. RESULTS: CLASS ATTENDANCE WAS 6.1 AND 5.8 FOR PROSTATE CANCER SURVIVORS (N = 15) AND THEIR SUPPORT PERSONS (N = 10), RESPECTIVELY, FOR THE 7 CLASSES. LEVELS OF PERCEIVED SOCIAL SUPPORT WERE HIGHER FOR THOSE WHO BROUGHT A SUPPORT PERSON. SIGNIFICANT IMPROVEMENTS WITH REGARD TO STRESS, FATIGUE, AND MOOD BEFORE AND AFTER YOGA CLASS (ALL PS < .05) WERE REPORTED BY ALL PARTICIPANTS. NO CLINICALLY SIGNIFICANT CHANGES WERE NOTED ON PROSTATE CANCER SURVIVOR'S QUALITY OF LIFE OR FATIGUE OVER THE COURSE OF THE 14-WEEK STUDY. CONCLUSIONS: YOGA IS A FEASIBLE PHYSICAL ACTIVITY OPTION FOR PROSTATE CANCER SURVIVORS. THE PROGRAM HAD A PROMISING UPTAKE RATE, HIGH PROGRAM ADHERENCE RATE, AND THERE WERE ACUTE PROGRAM BENEFITS WITH REGARD TO STRESS, FATIGUE, AND MOOD FOR ALL PARTICIPANTS. FUTURE EXAMINATION IS WARRANTED WITH REGARD TO CHRONIC BENEFITS AND GROUP COHESION INFLUENCES ON LEVELS OF PERCEIVED SOCIAL SUPPORT. 2013
19 2437 31 YOGA AND PSYCHOPHYSIOLOGICAL DETERMINANTS OF CARDIOVASCULAR HEALTH: COMPARING YOGA PRACTITIONERS, RUNNERS, AND SEDENTARY INDIVIDUALS. BACKGROUND: THE EVIDENCE OF CARDIOVASCULAR BENEFITS OF YOGA IS PROMISING, BUT LACKS DEMONSTRATIONS OF SPECIFICITY COMPARED TO OTHER INTERVENTIONS. PURPOSE: THE PRESENT CROSS-SECTIONAL STUDY EXAMINED CARDIOVASCULAR HEALTH MARKERS IN LONG-TERM PRACTITIONERS OF YOGA (YOGIS), RUNNERS, AND SEDENTARY INDIVIDUALS. METHODS: WE COMPARED PHYSIOLOGICAL, PSYCHOLOGICAL, AND LIFESTYLE VARIABLES ASSOCIATED WITH CARDIOVASCULAR HEALTH ACROSS GROUPS. RESULTS: YOGIS (N = 47) AND RUNNERS (N = 46) SHOWED FAVORABLE PROFILES COMPARED TO SEDENTARY INDIVIDUALS (N = 52) ON HEART RATE, HEART RATE VARIABILITY, DEPRESSION, PERCEIVED STRESS, AND CIGARETTE SMOKING. RUNNERS AND MALE YOGIS SHOWED SUPERIOR AEROBIC FITNESS COMPARED TO THE SEDENTARY GROUP. RUNNERS REPORTED GREATER SOCIAL SUPPORT COMPARED TO OTHER GROUPS. YOGIS DEMONSTRATED A LOWER RESPIRATION RATE COMPARED TO SEDENTARY INDIVIDUALS AND WERE MORE LIKELY TO REFRAIN FROM EATING MEAT COMPARED TO OTHER GROUPS. CONCLUSIONS: YOGIS AND RUNNERS DEMONSTRATED SEVERAL CARDIOVASCULAR HEALTH ADVANTAGES OVER SEDENTARY INDIVIDUALS. OUR FINDINGS RAISE THE POSSIBILITY THAT YOGA MAY IMPROVE AEROBIC FITNESS IN MEN BUT NOT WOMEN. 2014
20 1098 32 EFFECTS OF YOGA RESPIRATORY PRACTICE (BHASTRIKA PRANAYAMA) ON ANXIETY, AFFECT, AND BRAIN FUNCTIONAL CONNECTIVITY AND ACTIVITY: A RANDOMIZED CONTROLLED TRIAL. PRANAYAMA REFERS TO A SET OF YOGA BREATHING EXERCISES. RECENT EVIDENCE SUGGESTS THAT THE PRACTICE OF PRANAYAMA HAS POSITIVE EFFECTS ON MEASURES OF CLINICAL STRESS AND ANXIETY. THIS STUDY EXPLORED THE IMPACT OF A BHASTRIKA PRANAYAMA TRAINING PROGRAM ON EMOTION PROCESSING, ANXIETY, AND AFFECT. WE USED A RANDOMIZED CONTROLLED TRIAL DESIGN WITH THIRTY HEALTHY YOUNG ADULTS ASSESSED AT BASELINE AND AFTER 4 WEEKS OF PRANAYAMA PRACTICES. TWO FUNCTIONAL MAGNETIC RESONANCE IMAGING (MRI) PROTOCOLS WERE USED BOTH AT BASELINE AND POST-INTERVENTION: AN EMOTION TASK AS WELL AS A RESTING-STATE ACQUISITION. OUR RESULTS SUGGEST THAT PRANAYAMA SIGNIFICANTLY DECREASED STATES OF ANXIETY AND NEGATIVE AFFECT. THE PRACTICE OF PRANAYAMA ALSO MODULATED THE ACTIVITY OF BRAIN REGIONS INVOLVED IN EMOTIONAL PROCESSING, PARTICULARLY THE AMYGDALA, ANTERIOR CINGULATE, ANTERIOR INSULA, AND PREFRONTAL CORTEX. RESTING-STATE FUNCTIONAL MRI (FMRI) SHOWED SIGNIFICANTLY REDUCED FUNCTIONAL CONNECTIVITY INVOLVING THE ANTERIOR INSULA AND LATERAL PORTIONS OF THE PREFRONTAL CORTEX. CORRELATION ANALYSIS REVEALED THAT CHANGES IN CONNECTIVITY BETWEEN THE VENTROLATERAL PREFRONTAL CORTEX AND THE RIGHT ANTERIOR INSULA WERE ASSOCIATED WITH CHANGES IN ANXIETY. ALTHOUGH IT SHOULD BE NOTED THAT THESE ANALYSES WERE PRELIMINARY AND EXPLORATORY, IT PROVIDES THE FIRST EVIDENCE THAT 4 WEEKS OF B. PRANAYAMA SIGNIFICANTLY REDUCE THE LEVELS OF ANXIETY AND NEGATIVE AFFECT, AND THAT THESE CHANGES ARE ASSOCIATED WITH THE MODULATION OF ACTIVITY AND CONNECTIVITY IN BRAIN AREAS INVOLVED IN EMOTION PROCESSING, ATTENTION, AND AWARENESS. THE STUDY WAS REGISTERED AT HTTPS://WWW.ENSAIOSCLINICOS.GOV.BR/RG/RBR-2GV5C2/(RBR-2GV5C2). 2020