1 2371 116 WHAT HAS NEUROIMAGING TAUGHT US ON THE NEUROBIOLOGY OF YOGA? A REVIEW. YOGA IS BECOMING INCREASINGLY POPULAR WORLDWIDE, WITH SEVERAL IMPLICATED PHYSICAL AND MENTAL BENEFITS. HERE WE PROVIDE A COMPREHENSIVE AND CRITICAL REVIEW OF THE RESEARCH GENERATED FROM THE EXISTING NEUROIMAGING LITERATURE IN STUDIES OF YOGA PRACTITIONERS. WE REVIEWED 34 INTERNATIONAL PEER-REVIEWED NEUROIMAGING STUDIES OF YOGA USING MAGNETIC RESONANCE IMAGING (MRI), POSITRON EMISSION TOMOGRAPHY (PET), OR SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY (SPECT): 11 MORPHOLOGICAL AND 26 FUNCTIONAL STUDIES, INCLUDING THREE STUDIES THAT WERE CLASSIFIED AS BOTH MORPHOLOGICAL AND FUNCTIONAL. CONSISTENT FINDINGS INCLUDE INCREASED GRAY MATTER VOLUME IN THE INSULA AND HIPPOCAMPUS, INCREASED ACTIVATION OF PREFRONTAL CORTICAL REGIONS, AND FUNCTIONAL CONNECTIVITY CHANGES MAINLY WITHIN THE DEFAULT MODE NETWORK. THERE IS QUITE SOME VARIABILITY IN THE NEUROIMAGING FINDINGS THAT PARTIALLY REFLECTS DIFFERENT YOGA STYLES AND APPROACHES, AS WELL AS SAMPLE SIZE LIMITATIONS. DIRECT COMPARATOR GROUPS SUCH AS PHYSICAL ACTIVITY ARE SCARCELY USED SO FAR. FINALLY, HYPOTHESES ON THE UNDERLYING NEUROBIOLOGY DERIVED FROM THE IMAGING FINDINGS ARE DISCUSSED IN THE LIGHT OF THE POTENTIAL BENEFICIAL EFFECTS OF YOGA. 2020 2 1347 30 HYPOXIA IN CNS PATHOLOGIES: EMERGING ROLE OF MIRNA-BASED NEUROTHERAPEUTICS AND YOGA BASED ALTERNATIVE THERAPIES. CELLULAR RESPIRATION IS A VITAL PROCESS FOR THE EXISTENCE OF LIFE. ANY CONDITION THAT RESULTS IN DEPRIVATION OF OXYGEN (ALSO TERMED AS HYPOXIA) MAY EVENTUALLY LEAD TO DELETERIOUS EFFECTS ON THE FUNCTIONING OF TISSUES. BRAIN BEING THE HIGHEST CONSUMER OF OXYGEN IS PRONE TO INCREASED RISK OF HYPOXIA-INDUCED NEUROLOGICAL INSULTS. THIS IN TURN HAS BEEN ASSOCIATED WITH MANY DISEASES OF CENTRAL NERVOUS SYSTEM (CNS) SUCH AS STROKE, ALZHEIMER'S, ENCEPHALOPATHY ETC. ALTHOUGH SEVERAL STUDIES HAVE INVESTIGATED THE PATHOPHYSIOLOGICAL MECHANISMS UNDERLYING ISCHEMIC/HYPOXIC CNS DISEASES, THE KNOWLEDGE ABOUT PROTECTIVE THERAPEUTIC STRATEGIES TO AMELIORATE THE AFFECTED NEURONAL CELLS IS MEAGER. THIS HAS AUGMENTED THE NEED TO IMPROVE OUR UNDERSTANDING OF THE HYPOXIC AND ISCHEMIC EVENTS OCCURRING IN THE BRAIN AND IDENTIFY NOVEL AND ALTERNATE TREATMENT MODALITIES FOR SUCH INSULTS. MICRORNA (MIRNAS), SMALL NON-CODING RNA MOLECULES, HAVE RECENTLY EMERGED AS POTENTIAL NEUROPROTECTIVE AGENTS AS WELL AS TARGETS, UNDER HYPOXIC CONDITIONS. THESE 18-22 NUCLEOTIDE LONG RNA MOLECULES ARE PROFUSELY PRESENT IN BRAIN AND OTHER ORGANS AND FUNCTION AS GENE REGULATORS BY CLEAVING AND SILENCING THE GENE EXPRESSION. IN BRAIN, THESE ARE KNOWN TO BE INVOLVED IN NEURONAL DIFFERENTIATION AND PLASTICITY. THEREFORE, TARGETING MIRNA EXPRESSION REPRESENTS A NOVEL THERAPEUTIC APPROACH TO INTERCEDE AGAINST HYPOXIC AND ISCHEMIC BRAIN INJURY. IN THE FIRST PART OF THIS REVIEW, WE WILL DISCUSS THE NEUROPHYSIOLOGICAL CHANGES CAUSED AS A RESULT OF HYPOXIA, FOLLOWED BY THE CONTRIBUTION OF HYPOXIA IN THE NEURODEGENERATIVE DISEASES. SECONDLY, WE WILL PROVIDE RECENT UPDATES AND INSIGHTS INTO THE ROLES OF MIRNA IN THE REGULATION OF GENES IN OXYGEN AND GLUCOSE DEPRIVED BRAIN IN ASSOCIATION WITH CIRCADIAN RHYTHMS AND HOW THESE CAN BE TARGETED AS NEUROPROTECTIVE AGENTS FOR CNS INJURIES. FINALLY, WE WILL EMPHASIZE ON ALTERNATE BREATHING OR YOGIC INTERVENTIONS TO OVERCOME THE HYPOXIA ASSOCIATED ANOMALIES THAT COULD ULTIMATELY LEAD TO IMPROVEMENT IN CEREBRAL PERFUSION. 2017 3 1669 28 NEUROPHYSIOLOGICAL AND NEUROCOGNITIVE MECHANISMS UNDERLYING THE EFFECTS OF YOGA-BASED PRACTICES: TOWARDS A COMPREHENSIVE THEORETICAL FRAMEWORK. DURING RECENT DECADES NUMEROUS YOGA-BASED PRACTICES (YBP) HAVE EMERGED IN THE WEST, WITH THEIR AIMS RANGING FROM FITNESS GAINS TO THERAPEUTIC BENEFITS AND SPIRITUAL DEVELOPMENT. YOGA IS ALSO BEGINNING TO SPARK GROWING INTEREST WITHIN THE SCIENTIFIC COMMUNITY, AND YOGA-BASED INTERVENTIONS HAVE BEEN ASSOCIATED WITH MEASUREABLE CHANGES IN PHYSIOLOGICAL PARAMETERS, PERCEIVED EMOTIONAL STATES, AND COGNITIVE FUNCTIONING. YBP TYPICALLY INVOLVE A COMBINATION OF POSTURES OR MOVEMENT SEQUENCES, CONSCIOUS REGULATION OF THE BREATH, AND VARIOUS TECHNIQUES TO IMPROVE ATTENTIONAL FOCUS. HOWEVER, SO FAR LITTLE IF ANY RESEARCH HAS ATTEMPTED TO DECONSTRUCT THE ROLE OF THESE DIFFERENT COMPONENT PARTS IN ORDER TO BETTER UNDERSTAND THEIR RESPECTIVE CONTRIBUTION TO THE EFFECTS OF YBP. A CLEAR OPERATIONAL DEFINITION OF YOGA-BASED THERAPEUTIC INTERVENTIONS FOR SCIENTIFIC PURPOSES, AS WELL AS A COMPREHENSIVE THEORETICAL FRAMEWORK FROM WHICH TESTABLE HYPOTHESES CAN BE FORMULATED, IS THEREFORE NEEDED. HERE WE PROPOSE SUCH A FRAMEWORK, AND OUTLINE THE BOTTOM-UP NEUROPHYSIOLOGICAL AND TOP-DOWN NEUROCOGNITIVE MECHANISMS HYPOTHESIZED TO BE AT PLAY IN YBP. 2015 4 2431 22 YOGA AND PHYSIOTHERAPY: A SPECULATIVE REVIEW AND CONCEPTUAL SYNTHESIS. THIS ARTICLE PRESENTS THE POTENTIAL INTEGRATION OF YOGA AND PHYSIOTHERAPY WHEN CONSIDERING THE ESSENCE OF THEIR UNDERLYING CONCEPTS. WITHIN THE SCOPE OF THIS ARTICLE THE EXISTENCE OF SEVERAL SIMILARITIES BETWEEN THESE TWO 'CONCEPTS' HAS BEEN SUGGESTED. RESEARCHERS, PHYSIOTHERAPISTS AND THEIR PATIENTS AS WELL AS YOGA PRACTITIONERS CAN OBTAIN VALUABLE AND ADDITIONAL ARGUMENTS THROUGH THE CROSS-FERTILIZATION OF IDEAS ACROSS PRESENTED STUDIES UNITED BY SHARED, UNDERLYING CONCEPTS. THE PRACTICE OF YOGA IS BASED ON THE FOLLOWING ASSUMPTIONS: COMPLEXITY AND MULTIDIMENSIONALITY, VARIOUS POSITIVE INFLUENCES ON AN INDIVIDUAL'S WHOLENESS THROUGH THE MIND, BODY, AND THE RELATIONSHIPS BETWEEN THEM. THESE ASSUMPTIONS MAY HAVE THE POTENTIAL TO CONTRIBUTE TOWARDS THE PRACTICE OF PHYSIOTHERAPY AND ITS UNDERLYING PRINCIPLES. THE ESSENCE OF PHYSIOTHERAPY AS A MULTIFACETED PROCESS REQUIRES TEAMWORK AND EFFORTS OF VARIOUS SPECIALISTS LIKE PSYCHOLOGISTS, SOCIOLOGISTS, OCCUPATIONAL THERAPISTS AND NURSES IF PATIENTS ARE TO BENEFIT. IDEALLY, THE PHYSIOTHERAPIST SHOULD POSSESS KNOWLEDGE FROM THESE AREAS OF SCIENCE IN ORDER TO PROFESSIONALLY CARE ABOUT PATIENTS. THEREFORE, IT CAN BE SUGGESTED THAT BASIC SIMILARITIES EXIST BETWEEN YOGA AND PHYSIOTHERAPY IN TERMS OF MUTIDISCIPLINARITY AND COMPLEXITY OF HOLISTIC CARE. SUCH CONCEPTUAL ENRICHMENT MAY BE A USEFUL SOURCE OF INSPIRATION FOR PHYSIOTHERAPISTS CONCERNED ABOUT THEIR PATIENTS' OVERALL HEALTH ON A DAILY BASIS. THE AUTHORS EMPHASIZE THE USEFULNESS OF YOGA PRACTICE IN CLINICAL UNITS AND EXPLAIN HOW THE ESSENCE OF AYURVEDIC KNOWLEDGE MIGHT BE EXTRAPOLATED AND INCORPORATED INTO THEORETICAL PRINCIPLES OF PHYSIOTHERAPY PROCESS. THE JUSTIFICATION OF THE STUDIES INCLUDED IS ALSO PRESENTED. 2009 5 2886 22 YOGA: BALANCING THE EXCITATION-INHIBITION EQUILIBRIUM IN PSYCHIATRIC DISORDERS. SOCIAL BEHAVIORAL DISTURBANCES ARE CENTRAL TO MOST PSYCHIATRIC DISORDERS. A DISEQUILIBRIUM WITHIN THE CORTICAL EXCITATORY AND INHIBITORY NEUROTRANSMITTER SYSTEMS UNDERLIES THESE DEFICITS. GAMMA-AMINOBUTYRIC ACID (GABA) AND GLUTAMATE ARE THE MOST ABUNDANT EXCITATORY AND INHIBITORY NEUROTRANSMITTERS IN THE BRAIN THAT CONTRIBUTE TO THIS EQUILIBRIUM. SEVERAL CONTEMPORARY THERAPIES USED IN TREATING PSYCHIATRIC DISORDERS, REGULATE THIS GABA-GLUTAMATE BALANCE. YOGA HAS BEEN STUDIED AS AN ADJUVANT TREATMENT ACROSS A BROAD RANGE OF PSYCHIATRIC DISORDERS AND IS SHOWN TO HAVE SHORT-TERM THERAPEUTIC GAINS. EMERGING EVIDENCE FROM RECENT CLINICAL IN VIVO EXPERIMENTS SUGGESTS THAT YOGA IMPROVES GABA-MEDIATED CORTICAL-INHIBITORY TONE AND ENHANCES PERIPHERAL OXYTOCIN LEVELS. THIS IS LIKELY TO HAVE A MORE CONTROLLED DOWNSTREAM RESPONSE OF THE HYPOTHALAMO-PITUITARY-ADRENAL SYSTEM BY MEANS OF REDUCED CORTISOL RELEASE AND HENCE A BLUNTED SYMPATHETIC RESPONSE TO STRESS. ANIMAL AND EARLY FETAL DEVELOPMENTAL STUDIES SUGGEST AN INTER-DEPENDENT ROLE OF OXYTOCIN AND GABA IN REGULATING SOCIAL BEHAVIORS. IN KEEPING WITH THESE OBSERVATIONS, WE PROPOSE AN INTEGRATED NEUROBIOLOGICAL MODEL TO STUDY THE MECHANISMS OF THERAPEUTIC BENEFITS WITH YOGA. APART FROM PROVIDING A NEUROSCIENTIFIC BASIS FOR APPLYING A TRADITIONAL SYSTEM OF PRACTICE IN THE CLINICAL SETTING, THIS MODEL CAN BE USED AS A FRAMEWORK FOR STUDYING YOGA MECHANISMS IN FUTURE CLINICAL TRIALS. 2019 6 2531 37 YOGA EFFECTS ON BRAIN HEALTH: A SYSTEMATIC REVIEW OF THE CURRENT LITERATURE. YOGA IS THE MOST POPULAR COMPLEMENTARY HEALTH APPROACH PRACTICED BY ADULTS IN THE UNITED STATES. IT IS AN ANCIENT MIND AND BODY PRACTICE WITH ORIGINS IN INDIAN PHILOSOPHY. YOGA COMBINES PHYSICAL POSTURES, RHYTHMIC BREATHING AND MEDITATIVE EXERCISE TO OFFER THE PRACTITIONERS A UNIQUE HOLISTIC MIND-BODY EXPERIENCE. WHILE THE HEALTH BENEFITS OF PHYSICAL EXERCISE ARE WELL ESTABLISHED, IN RECENT YEARS, THE ACTIVE ATTENTIONAL COMPONENT OF BREATHING AND MEDITATION PRACTICE HAS GARNERED INTEREST AMONG EXERCISE NEUROSCIENTISTS. AS THE SCIENTIFIC EVIDENCE FOR THE PHYSICAL AND MENTAL HEALTH BENEFITS OF YOGA CONTINUES TO GROW, THIS ARTICLE AIMS TO SUMMARIZE THE CURRENT KNOWLEDGE OF YOGA PRACTICE AND ITS DOCUMENTED POSITIVE EFFECTS FOR BRAIN STRUCTURE AND FUNCTION, AS ASSESSED WITH MRI, FMRI, AND SPECT. WE REVIEWED 11 STUDIES EXAMINING THE EFFECTS OF YOGA PRACTICE ON THE BRAIN STRUCTURES, FUNCTION AND CEREBRAL BLOOD FLOW. COLLECTIVELY, THE STUDIES DEMONSTRATE A POSITIVE EFFECT OF YOGA PRACTICE ON THE STRUCTURE AND/OR FUNCTION OF THE HIPPOCAMPUS, AMYGDALA, PREFRONTAL CORTEX, CINGULATE CORTEX AND BRAIN NETWORKS INCLUDING THE DEFAULT MODE NETWORK (DMN). THE STUDIES OFFER PROMISING EARLY EVIDENCE THAT BEHAVIORAL INTERVENTIONS LIKE YOGA MAY HOLD PROMISE TO MITIGATE AGE-RELATED AND NEURODEGENERATIVE DECLINES AS MANY OF THE REGIONS IDENTIFIED ARE KNOWN TO DEMONSTRATE SIGNIFICANT AGE-RELATED ATROPHY. 2019 7 1639 16 MODULATION OF IMMUNE RESPONSES IN STRESS BY YOGA. STRESS IS A CONSTANT FACTOR IN TODAY'S FASTPACED LIFE THAT CAN JEOPARDIZE OUR HEALTH IF LEFT UNCHECKED. IT IS ONLY IN THE LAST HALF CENTURY THAT THE ROLE OF STRESS IN EVERY AILMENT FROM THE COMMON COLD TO AIDS HAS BEEN EMPHASIZED, AND THE MECHANISMS INVOLVED IN THIS PROCESS HAVE BEEN STUDIED. STRESS INFLUENCES THE IMMUNE RESPONSE PRESUMABLY THROUGH THE ACTIVATION OF THE HYPOTHALAMIC-PITUITARY ADRENAL AXIS, HYPOTHALAMIC PITUITARY-GONADAL AXIS, AND THE SYMPATHETIC-ADRENAL-MEDULLARY SYSTEM. VARIOUS NEUROTRANSMITTERS, NEUROPEPTIDES, HORMONES, AND CYTOKINES MEDIATE THESE COMPLEX BIDIRECTIONAL INTERACTIONS BETWEEN THE CENTRAL NERVOUS SYSTEM (CNS) AND THE IMMUNE SYSTEM. THE EFFECTS OF STRESS ON THE IMMUNE RESPONSES RESULT IN ALTERATIONS IN THE NUMBER OF IMMUNE CELLS AND CYTOKINE DYSREGULATION. VARIOUS STRESS MANAGEMENT STRATEGIES SUCH AS MEDITATION, YOGA, HYPNOSIS, AND MUSCLE RELAXATION HAVE BEEN SHOWN TO REDUCE THE PSYCHOLOGICAL AND PHYSIOLOGICAL EFFECTS OF STRESS IN CANCERS AND HIV INFECTION. THIS REVIEW AIMS TO DISCUSS THE EFFECT OF STRESS ON THE IMMUNE SYSTEM AND EXAMINE HOW RELAXATION TECHNIQUES SUCH AS YOGA AND MEDITATION COULD REGULATE THE CYTOKINE LEVELS AND HENCE, THE IMMUNE RESPONSES DURING STRESS. 2008 8 1590 20 MEDITATION AND YOGA CAN MODULATE BRAIN MECHANISMS THAT AFFECT BEHAVIOR AND ANXIETY-A MODERN SCIENTIFIC PERSPECTIVE. MEDITATION AND YOGA TECHNIQUES ARE RECEIVING INCREASED ATTENTION THROUGHOUT THE WORLD, DUE TO THE ACCUMULATION OF EVIDENCE BASED RESEARCH THAT PROVES THE DIRECT AND INDIRECT BENEFITS OF SUCH PRACTICES. BASED ON STUDIES CONDUCTED SO FAR, IT HAS BEEN FOUND THAT THE PRACTICE OF MEDITATION TRIGGERS NEUROTRANSMITTERS THAT MODULATE PSYCHOLOGICAL DISORDERS SUCH AS ANXIETY. THIS PAPER WILL REVIEW THE PSYCHOLOGICAL EFFECTS OF THE PRACTICE OF MEDITATION, THE ROLE OF NEUROTRANSMITTERS, AND STUDIES USING EEG AND FMRI. 2015 9 76 24 A HEURISTIC MODEL LINKING YOGA PHILOSOPHY AND SELF-REFLECTION TO EXAMINE UNDERLYING MECHANISMS OF ADD-ON YOGA TREATMENT IN SCHIZOPHRENIA. PRELIMINARY EVIDENCE SUGGESTS EFFICACY OF YOGA AS ADD-ON TREATMENT FOR SCHIZOPHRENIA, BUT THE UNDERLYING MECHANISM BY WHICH YOGA IMPROVES THE SYMPTOMS OF SCHIZOPHRENIA IS NOT COMPLETELY UNDERSTOOD. YOGA IMPROVES SELF-REFLECTION IN HEALTHY INDIVIDUALS, AND SELF-REFLECTION ABNORMALITIES ARE TYPICALLY SEEN IN SCHIZOPHRENIA. HOWEVER, WHETHER YOGA TREATMENT IMPROVES IMPAIRMENTS IN SELF-REFLECTION TYPICALLY SEEN IN PATIENTS WITH SCHIZOPHRENIA IS NOT EXAMINED. THIS PAPER DISCUSSES THE POTENTIAL MECHANISM OF YOGA IN THE TREATMENT OF SCHIZOPHRENIA AND PROPOSES A TESTABLE HYPOTHESIS FOR FURTHER EMPIRICAL STUDIES. IT IS PROPOSED THAT SELF-REFLECTION ABNORMALITIES IN SCHIZOPHRENIA IMPROVE WITH YOGA AND THE NEUROBIOLOGICAL CHANGES ASSOCIATED WITH THIS CAN BE EXAMINED USING EMPIRICAL BEHAVIOURAL MEASURES AND NEUROIMAGING MEASURES SUCH AS MAGNETIC RESONANCE IMAGING. 2016 10 1089 23 EFFECTS OF YOGA ON THE AUTONOMIC NERVOUS SYSTEM, GAMMA-AMINOBUTYRIC-ACID, AND ALLOSTASIS IN EPILEPSY, DEPRESSION, AND POST-TRAUMATIC STRESS DISORDER. A THEORY IS PROPOSED TO EXPLAIN THE BENEFITS OF YOGA PRACTICES IN DIVERSE, FREQUENTLY COMORBID MEDICAL CONDITIONS BASED ON THE CONCEPT THAT YOGA PRACTICES REDUCE ALLOSTATIC LOAD IN STRESS RESPONSE SYSTEMS SUCH THAT OPTIMAL HOMEOSTASIS IS RESTORED. IT IS HYPOTHESIZED THAT STRESS INDUCES (1) IMBALANCE OF THE AUTONOMIC NERVOUS SYSTEM (ANS) WITH DECREASED PARASYMPATHETIC NERVOUS SYSTEM (PNS) AND INCREASED SYMPATHETIC NERVOUS SYSTEM (SNS) ACTIVITY, (2) UNDERACTIVITY OF THE GAMMA AMINO-BUTYRIC ACID (GABA) SYSTEM, THE PRIMARY INHIBITORY NEUROTRANSMITTER SYSTEM, AND (3) INCREASED ALLOSTATIC LOAD. IT IS FURTHER HYPOTHESIZED THAT YOGA-BASED PRACTICES (4) CORRECT UNDERACTIVITY OF THE PNS AND GABA SYSTEMS IN PART THROUGH STIMULATION OF THE VAGUS NERVES, THE MAIN PERIPHERAL PATHWAY OF THE PNS, AND (5) REDUCE ALLOSTATIC LOAD. DEPRESSION, EPILEPSY, POST TRAUMATIC STRESS DISORDER (PTSD), AND CHRONIC PAIN EXEMPLIFY MEDICAL CONDITIONS THAT ARE EXACERBATED BY STRESS, HAVE LOW HEART RATE VARIABILITY (HRV) AND LOW GABAERGIC ACTIVITY, RESPOND TO PHARMACOLOGIC AGENTS THAT INCREASE ACTIVITY OF THE GABA SYSTEM, AND SHOW SYMPTOM IMPROVEMENT IN RESPONSE TO YOGA-BASED INTERVENTIONS. THE OBSERVATION THAT TREATMENT RESISTANT CASES OF EPILEPSY AND DEPRESSION RESPOND TO VAGAL NERVE STIMULATION CORROBORATES THE NEED TO CORRECT PNS UNDERACTIVITY AS PART OF A SUCCESSFUL TREATMENT PLAN IN SOME CASES. ACCORDING TO THE PROPOSED THEORY, THE DECREASED PNS AND GABAERGIC ACTIVITY THAT UNDERLIES STRESS-RELATED DISORDERS CAN BE CORRECTED BY YOGA PRACTICES RESULTING IN AMELIORATION OF DISEASE SYMPTOMS. THIS HAS FAR-REACHING IMPLICATIONS FOR THE INTEGRATION OF YOGA-BASED PRACTICES IN THE TREATMENT OF A BROAD ARRAY OF DISORDERS EXACERBATED BY STRESS. 2012 11 1335 26 HOW DOES YOGA PRACTICE AND THERAPY YIELD PSYCHOLOGICAL BENEFITS? A REVIEW AND MODEL OF TRANSDIAGNOSTIC PROCESSES. INTEREST IN YOGA AS AN INTERVENTION FOR PSYCHOLOGICAL WELLBEING HAS INCREASED IN RECENT YEARS, WITH LITERATURE INVESTIGATING BENEFICIAL EFFECTS IN A VARIETY OF PRESENTATIONS AND SETTINGS. THE THEORETICAL UNDERSTANDING OF THIS BENEFIT HAS PREVIOUSLY FOCUSED ON PHYSIOLOGICAL CHANGES INVOLVED IN YOGA PRACTICE, HOWEVER INTEREST HAS TURNED TO THE POTENTIAL PSYCHOLOGICAL MECHANISMS ELICITING PSYCHOLOGICAL WELLBEING. THE CURRENT PAPER BUILDS ON PREVIOUS THEORY AND ARGUES THAT YOGA PRACTICE TARGETS TRANSDIAGNOSTIC PSYCHOLOGICAL PROCESSES; MECHANISMS THAT FEATURE COMMONLY ACROSS A WIDE RANGE OF PRESENTATIONS, THUS REDUCING DISTRESS AND INCREASING WELLBEING ACROSS CLINICAL AND NON-CLINICAL POPULATIONS. FEATURES OF YOGA PRACTICE ARE DISCUSSED IN RELATION TO THESE TRANSDIAGNOSTIC PROCESSES AND THE FEATURES OF MODERN TALKING THERAPIES. A NEW MODEL IS PROPOSED POSITING SPECIFIC ASPECTS OF YOGA PRACTICE CORRELATE WITH SPECIFIC TRANSDIAGNOSTIC PROCESSES TO ELICIT PSYCHOLOGICAL CHANGE AND ARGUES THAT THE MECHANISMS BY WHICH CHANGE OCCURS ARE DIRECTLY COMPARED WITH THE CHANGES OBSERVED IN TALKING THERAPIES. THE IMPLICATIONS FOR FUTURE RESEARCH AND THE POTENTIAL FOR THIS TO SUPPORT THE COMMISSIONING OF HOLISTIC APPROACHES IN CLINICAL PRACTICE ARE DISCUSSED. 2022 12 93 27 A NARRATIVE REVIEW OF YOGA AND MINDFULNESS AS COMPLEMENTARY THERAPIES FOR ADDICTION. THIS PAPER REVIEWS THE PHILOSOPHICAL ORIGINS, CURRENT SCIENTIFIC EVIDENCE, AND CLINICAL PROMISE OF YOGA AND MINDFULNESS AS COMPLEMENTARY THERAPIES FOR ADDICTION. HISTORICALLY, THERE ARE EIGHT ELEMENTS OF YOGA THAT, TOGETHER, COMPRISE ETHICAL PRINCIPLES AND PRACTICES FOR LIVING A MEANINGFUL, PURPOSEFUL, MORAL AND SELF-DISCIPLINED LIFE. TRADITIONAL YOGA PRACTICES, INCLUDING POSTURES AND MEDITATION, DIRECT ATTENTION TOWARD ONE'S HEALTH, WHILE ACKNOWLEDGING THE SPIRITUAL ASPECTS OF ONE'S NATURE. MINDFULNESS DERIVES FROM ANCIENT BUDDHIST PHILOSOPHY, AND MINDFULNESS MEDITATION PRACTICES, SUCH AS GENTLE HATHA YOGA AND MINDFUL BREATHING, ARE INCREASINGLY INTEGRATED INTO SECULAR HEALTH CARE SETTINGS. CURRENT THEORETICAL MODELS SUGGEST THAT THE SKILLS, INSIGHTS, AND SELF-AWARENESS LEARNED THROUGH YOGA AND MINDFULNESS PRACTICE CAN TARGET MULTIPLE PSYCHOLOGICAL, NEURAL, PHYSIOLOGICAL, AND BEHAVIORAL PROCESSES IMPLICATED IN ADDICTION AND RELAPSE. A SMALL BUT GROWING NUMBER OF WELL-DESIGNED CLINICAL TRIALS AND EXPERIMENTAL LABORATORY STUDIES ON SMOKING, ALCOHOL DEPENDENCE, AND ILLICIT SUBSTANCE USE SUPPORT THE CLINICAL EFFECTIVENESS AND HYPOTHESIZED MECHANISMS OF ACTION UNDERLYING MINDFULNESS-BASED INTERVENTIONS FOR TREATING ADDICTION. BECAUSE VERY FEW STUDIES HAVE BEEN CONDUCTED ON THE SPECIFIC ROLE OF YOGA IN TREATING OR PREVENTING ADDICTION, WE PROPOSE A CONCEPTUAL MODEL TO INFORM FUTURE STUDIES ON OUTCOMES AND POSSIBLE MECHANISMS. ADDITIONAL RESEARCH IS ALSO NEEDED TO BETTER UNDERSTAND WHAT TYPES OF YOGA AND MINDFULNESS-BASED INTERVENTIONS WORK BEST FOR WHAT TYPES OF ADDICTION, WHAT TYPES OF PATIENTS, AND UNDER WHAT CONDITIONS. OVERALL, CURRENT FINDINGS INCREASINGLY SUPPORT YOGA AND MINDFULNESS AS PROMISING COMPLEMENTARY THERAPIES FOR TREATING AND PREVENTING ADDICTIVE BEHAVIORS. 2013 13 2608 15 YOGA FOR PSYCHIATRIC DISORDERS: FROM FAD TO EVIDENCE-BASED INTERVENTION? THERE IS GROWING EVIDENCE FOR YOGA'S NEUROBIOLOGICAL EFFECTS IN PEOPLE WITH PSYCHIATRIC DISORDERS. POSTULATED MECHANISMS OF ACTION INCLUDE: (A) MODULATION OF THE HYPOTHALAMIC-PITUITARY-ADRENAL (HPA) AXIS; (B) ENHANCEMENT OF GABAERGIC NEUROTRANSMISSION; (C) AUTONOMIC MODULATION; AND (D) NEUROENDOCRINOLOGICAL EFFECTS. YOGA AS A THERAPEUTIC INTERVENTION IN PSYCHIATRIC DISORDERS APPEARS PROMISING AND MERITS FURTHER ATTENTION IN CLINICAL PRACTICE AND RESEARCH. 2020 14 1772 25 POTENTIAL SELF-REGULATORY MECHANISMS OF YOGA FOR PSYCHOLOGICAL HEALTH. RESEARCH SUGGESTING THE BENEFICIAL EFFECTS OF YOGA ON MYRIAD ASPECTS OF PSYCHOLOGICAL HEALTH HAS PROLIFERATED IN RECENT YEARS, YET THERE IS CURRENTLY NO OVERARCHING FRAMEWORK BY WHICH TO UNDERSTAND YOGA'S POTENTIAL BENEFICIAL EFFECTS. HERE WE PROVIDE A THEORETICAL FRAMEWORK AND SYSTEMS-BASED NETWORK MODEL OF YOGA THAT FOCUSES ON INTEGRATION OF TOP-DOWN AND BOTTOM-UP FORMS OF SELF-REGULATION. WE BEGIN BY CONTEXTUALIZING YOGA IN HISTORICAL AND CONTEMPORARY SETTINGS, AND THEN DETAIL HOW SPECIFIC COMPONENTS OF YOGA PRACTICE MAY AFFECT COGNITIVE, EMOTIONAL, BEHAVIORAL, AND AUTONOMIC OUTPUT UNDER STRESS THROUGH AN EMPHASIS ON INTEROCEPTION AND BOTTOM-UP INPUT, RESULTING IN PHYSICAL AND PSYCHOLOGICAL HEALTH. THE MODEL DESCRIBES YOGA PRACTICE AS A COMPREHENSIVE SKILLSET OF SYNERGISTIC PROCESS TOOLS THAT FACILITATE BIDIRECTIONAL FEEDBACK AND INTEGRATION BETWEEN HIGH- AND LOW-LEVEL BRAIN NETWORKS, AND AFFERENT AND RE-AFFERENT INPUT FROM INTEROCEPTIVE PROCESSES (SOMATOSENSORY, VISCEROSENSORY, CHEMOSENSORY). FROM A PREDICTIVE CODING PERSPECTIVE WE PROPOSE A SHIFT TO PERCEPTUAL INFERENCE FOR STRESS MODULATION AND OPTIMAL SELF-REGULATION. WE DESCRIBE HOW THE PROCESSES THAT SUB-SERVE SELF-REGULATION BECOME MORE AUTOMATIZED AND EFFICIENT OVER TIME AND PRACTICE, REQUIRING LESS EFFORT TO INITIATE WHEN NECESSARY AND TERMINATE MORE RAPIDLY WHEN NO LONGER NEEDED. TO SUPPORT OUR PROPOSED MODEL, WE PRESENT THE AVAILABLE EVIDENCE FOR YOGA AFFECTING SELF-REGULATORY PATHWAYS, INTEGRATING EXISTING CONSTRUCTS FROM BEHAVIOR THEORY AND COGNITIVE NEUROSCIENCE WITH EMERGING YOGA AND MEDITATION RESEARCH. THIS PAPER IS INTENDED TO GUIDE FUTURE BASIC AND CLINICAL RESEARCH, SPECIFICALLY TARGETING AREAS OF DEVELOPMENT IN THE TREATMENT OF STRESS-MEDIATED PSYCHOLOGICAL DISORDERS. 2014 15 588 33 DETERMINING PSYCHONEUROIMMUNOLOGIC MARKERS OF YOGA AS AN INTERVENTION FOR PERSONS DIAGNOSED WITH PTSD: A SYSTEMATIC REVIEW. THERE IS A GROWING BODY OF RESEARCH ON YOGA AS A THERAPEUTIC INTERVENTION FOR PSYCHOLOGICAL SYMPTOMS OF POST-TRAUMATIC STRESS DISORDER (PTSD) ACCOMPANIED BY SPECULATIONS ON UNDERLYING PHYSIOLOGIC MECHANISMS. THE PURPOSE OF THIS SYSTEMATIC REVIEW IS TO IDENTIFY, QUALITATIVELY EVALUATE, AND SYNTHESIZE STUDIES OF YOGA AS AN INTERVENTION FOR PTSD THAT MEASURED PHYSIOLOGIC OUTCOMES IN ORDER TO GAIN INSIGHTS INTO POTENTIAL MECHANISMS. THE FOCUS IS ON STUDIES EVALUATING YOGA AS A THERAPEUTIC INTERVENTION FOR PTSD RATHER THAN FOR TRAUMA EXPOSURE, PTSD PREVENTION, OR SUBCLINICAL PTSD. MULTIPLE DATABASES WERE SEARCHED FOR PUBLICATIONS FROM THE PAST TWO DECADES USING TERMS DERIVED FROM THE QUESTION, "IN PEOPLE WITH PTSD, WHAT IS THE EFFECT OF YOGA ON OBJECTIVE OUTCOMES?" ELIGIBILITY CRITERIA INCLUDED YOGA-ONLY MODALITIES TESTED AS AN INTERVENTION FOR FORMALLY DIAGNOSED PTSD WITH AT LEAST ONE PHYSIOLOGIC OUTCOME. RESULTS OF THIS REVIEW CONFIRMED THAT, THOUGH MUCH OF THE PUBLISHED LITERATURE PROPOSES PHYSIOLOGICAL MECHANISMS UNDERLYING YOGA'S EFFECTS ON PTSD, VERY FEW STUDIES ( N = 3) HAVE ACTUALLY EVALUATED PHYSIOLOGICAL EVIDENCE. ADDITIONALLY, SEVERAL STUDIES HAD METHODOLOGICAL LIMITATIONS. IN LIGHT OF THE LIMITED DATA SUPPORTING YOGA'S BENEFICIAL EFFECTS ON AUTONOMIC NERVOUS SYSTEM DYSREGULATION, WE PRESENT A THEORETICAL MODEL OF THE PSYCHONEUROIMMUNOLOGIC PROCESSES ASSOCIATED WITH PTSD AND THE EFFECTS YOGA MAY HAVE ON THESE PROCESSES TO GUIDE FUTURE RESEARCH. GAPS IN THE LITERATURE REMAIN FOR MECHANISMS RELATED TO ACTIVATION OF THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS AND INFLAMMATION. ADDITIONAL RIGOROUS MECHANISTIC STUDIES ARE NEEDED TO GUIDE DEVELOPMENT OF EFFECTIVE YOGA INTERVENTIONS FOR PTSD TO AUGMENT EXISTING EVIDENCE-BASED PTSD TREATMENTS. 2018 16 1698 26 PAIN-RELATED ENCEPHALIC REGIONS INFLUENCED BY YOGA MEDITATION: AN INTEGRATIVE REVIEW. INTRODUCTION: THE MECHANISMS UNDERLYING THE USE OF YOGA IN PAIN RELIEF ARE STILL UNCLEAR. THIS STUDY REVIEWED LITERATURE REPORTS ON ENCEPHALIC ACTIVITY RELATED TO ANALGESIA INDUCED BY YOGA MEDITATION PRACTICE. METHODS: THIS INTEGRATIVE REVIEW EXAMINED STUDIES PUBLISHED IN THE PUBMED, LILACS AND MEDLINE DATABASES WITHOUT RESTRICTION OF THE YEAR OF PUBLICATION. THE RESEARCH INVOLVED 16 DESCRIPTORS RELATED TO THE WORDS: YOGA, PAIN AND NEUROIMAGING METHODS. INCLUSION CRITERIA INVOLVED ONLY THE PUBLICATIONS AVAILABLE ONLINE, WITH FREE ACCESS AND WRITTEN IN ENGLISH. RESULTS: 2 CASE STUDIES AND 1 PILOT STUDY MET THE CRITERIA. YOGA MEDITATION PRACTICE INDUCES ANALGESIA PRIMARILY THROUGH ATTENUATION OF THE MEDIAL PAIN PERCEPTION SYSTEM INCLUDING THE ANTERIOR CINGULATE CORTEX AND INSULA REGIONS, AS WELL AS THE LATERAL SYSTEM INCLUDING THE SECONDARY SENSORY CORTEX AND THALAMUS. CONCLUSION: YOGA INDUCED ANALGESIA IS A POTENTIALLY IMPORTANT ADJUNCT TO CURRENT PAIN MANAGEMENT. THIS INTEGRATIVE REVIEW REVEALED THAT THERE IS A NEED FOR FURTHER RESEARCH THAT ANALYZES THE ENCEPHALIC REGIONS RELATED TO ANALGESIA INDUCED BY YOGA PRACTICE. 2018 17 1817 17 PROPOSED IDENTIFICATION OF PHYSIOLOGICAL CLASSIFICATION AND THEORETICAL MECHANISMS OF YOGASANAS. YOGA IN THE THEORETICAL AND PRACTICAL FORM IS NOW ACCEPTED ALL OVER THE WORLD, BY THE RESEARCHERS AS WELL AS BY THE GENERAL POPULATION. YOGASANA OR YOGIC POSTURES ARE ONE OF THE MAIN FOUNDATIONS OF PRACTICAL YOGA. MECHANISMS OF MEDIATION AND PRANAYAMA HAS ALREADY BEEN ESTABLISHED. IN THIS ARTICLE, THE AUTHOR IS FOR THE FIRST TIME PROPOSING PHYSIOLOGICAL CLASSIFICATION OF YOGASANA I.E. (A) STRETCH (B) CONTRACTION (C). NEUROMUSCULAR COORDINATION (D) SENSE REDUCTION (E) SPINE BRAIN ACTIVATION. IN SUPPORT OF THIS PHYSIOLOGICAL CLASSIFICATION AUTHOR HAS PROPOSED FIVE HYPOTHETICAL THEORIES I.E. (I) STRETCH RELAXATION AWARENESS (II) CONTRACTION RELAXATION AWARENESS (III) BALLASTIC CONTRACTION RELAXATION AWARENESS (IV) SENSORY MOTOR FUNCTION AWARENESS AND (V) VITAL ENERGY FLOW AWARENESS TO UNDERSTAND THE UNDERLYING MECHANISMS OF YOGASANA PRACTICE AND TO EXPLAIN ITS BENEFITS. 2021 18 1824 30 PSYCHO-NEURO-ENDOCRINE-IMMUNE MECHANISMS OF ACTION OF YOGA IN TYPE II DIABETES. YOGA HAS BEEN FOUND TO BENEFIT ALL THE COMPONENTS OF HEALTH VIZ. PHYSICAL, MENTAL, SOCIAL AND SPIRITUAL WELL BEING BY INCORPORATING A WIDE VARIETY OF PRACTICES. PATHOPHYSIOLOGY OF TYPE II DM AND CO-MORBIDITIES IN TYPE II DM HAS BEEN CORRELATED WITH STRESS MECHANISMS. STRESS SUPPRESSES BODY'S IMMUNE SYSTEM AND NEURO-HUMORAL ACTIONS THEREBY AFF ECTING NORMAL PSYCHOLOGICAL STATE. IT WOULD NOT BE WRONG TO STATE THAT CORRELATION OF DIABETES WITH STRESS, ANXIETY AND OTHER PSYCHOLOGICAL FACTORS ARE BIDIRECTIONAL AND LEAD TO DIFFICULTY IN UNDERSTANDING THE INTERRELATED MECHANISMS. TYPE II DM CANNOT BE UNDERSTOOD IN ISOLATION WITH PSYCHOLOGICAL FACTORS SUCH AS STRESS, ANXIETY AND DEPRESSION, NEURO-ENDOCRINE AND IMMUNOLOGICAL FACTORS. THERE IS NO REVIEW WHICH TRIES TO UNDERSTAND THESE MECHANISMS EXCLUSIVELY. THE PRESENT LITERATURE REVIEW AIMS TO UNDERSTAND INTERRELATED PSYCHO-NEURO-ENDOCRINE AND IMMUNOLOGICAL MECHANISMS OF ACTION OF YOGA IN TYPE II DIABETES MELLITUS. PUBLISHED LITERATURE CONCERNING MECHANISMS OF ACTION OF YOGA IN TYPE II DM EMPHASIZING PSYCHO-NEURO-ENDOCRINE OR IMMUNOLOGICAL RELATIONS WAS RETRIEVED FROM PUBMED USING KEY WORDS YOGA, TYPE II DIABETES MELLITUS, PSYCHOLOGICAL, NEURAL, ENDOCRINE, IMMUNE AND MECHANISM OF ACTION. THOSE STUDIES WHICH EXPLAINED THE PSYCHO-NEUROENDOCRINE AND IMMUNE MECHANISMS OF ACTION OF YOGA WERE INCLUDED AND REST WERE EXCLUDED. ALTHOUGH PRIMARY AIM OF THIS STUDY IS TO EXPLAIN THESE MECHANISMS IN TYPE II DM, SOME STUDIES IN NON-DIABETIC POPULATION WHICH HAD A SIMILAR PATHWAY OF STRESS MECHANISM WAS INCLUDED BECAUSE MANY INSIGHTFUL STUDIES WERE AVAILABLE IN THAT AREA. SEARCH WAS CONDUCTED USING TERMS YOGA OR YOGIC AND DIABETES OR DIABETIC IN TITLE OR ABSTRACT FOR ENGLISH ARTICLES. OF THE 89 ARTICLES, WE EXCLUDED NON-ENGLISH ARTICLES (22), EDITORIALS (20) AND LETTERS TO EDITOR (10). 37 STUDIES WERE CONSIDERED FOR THIS REVIEW. THE POSTULATED MECHANISM OF ACTION OF YOGA IS THROUGH PARASYMPATHETIC ACTIVATION AND THE ASSOCIATED ANTI STRESS MECHANISM. IT REDUCES PERCEIVED STRESS AND HPA AXIS ACTIVATION THEREBY IMPROVING OVERALL METABOLIC AND PSYCHOLOGICAL PROFILES, INCREASING INSULIN SENSITIVITY, AND IMPROVING GLUCOSE TOLERANCE AND LIPID METABOLISM. YOGA HAS POSITIVE EFFECTS ON IMMUNE SYSTEM OF DIABETICS.- OVERALL, TYPE II DM IS INFLUENCED BY PSYCHO-NEURO-ENDOCRINE AND IMMUNE MECHANISMS WHERE YOGA HAS IMPORTANT POSITIVE ROLE IN COMBATING STRESSORS AND IMPROVING THESE SYSTEMS TO REGAIN HEALTH. 2015 19 571 21 DEFINING YOGA-NIDRA: TRADITIONAL ACCOUNTS, PHYSIOLOGICAL RESEARCH, AND FUTURE DIRECTIONS. THE TERM YOGA-NIDRA HAS BEEN USED IN MANY EMPIRICAL STUDIES TO REFER TO RELAXATION AND GUIDED IMAGERY. THESE TECHNIQUES DO NOT REPRESENT THE INTENTION OR PHYSIOLOGICAL CORRELATES OF YOGANIDRA DISCUSSED IN THE TRADITIONAL YOGA LITERATURE. WE PROPOSE AN OPERATIONAL DEFINITION OF YOGA-NIDRA THAT IS SUPPORTED BY SEVERAL PHYSIOLOGICALLY TESTABLE HYPOTHESES REGARDING ITS OUTCOMES AND EFFECTS. TRADITIONAL DESCRIPTIONS OF YOGA-NIDRA AND CONTEMPORARY ACCOUNTS OF ITS PRACTICE ARE REVIEWED, AND STUDIES EXAMINING THE PHYSIOLOGICAL CORRELATES OF YOGA-NIDRA ARE EXAMINED. PROPOSED HYPOTHESES FOR FUTURE RESEARCH USING THIS OPERATIONAL DEFINITION ARE PROVIDED. 2013 20 2267 22 THE QIGONG OF 18 LUOHAN HANDS AND YOGA FOR PREVENTION OF LOW BACK PAIN: A CONCEPTUAL SYNTHESIS. THE PRACTICE OF HATHAYOGA IS BASED ON THE FOLLOWING ASSUMPTIONS: COMPLEXITY AND MULTIDIMENSIONALITY OF VARIOUS POSITIVE INFLUENCES ON AN INDIVIDUAL'S WHOLENESS THROUGH THE MIND, BODY AND THEIR CONSCIOUS CONTROL. ON THE OTHER HAND, THE PRACTICE OF THE QIGONG OF 18 LUOHAN HANDS IS BASED ON SLOW MOVEMENTS DESIGNED TO MOBILISE QI WITHIN THE BODY. THIS ARTICLE PRESENTS A CONCEPTUAL INTEGRATION OF YOGA AND QIGONG WHEN CONSIDERING THE CONGRUENCE OF BENEFICIAL EFFECTS FOR VARIOUS SYSTEMS OF THE BODY AND PREVENTION OF LOW BACK PAIN (LBP). THE AUTHOR EMPHASIZES THE USEFULNESS OF QIGONG AND YOGA PRACTICE IN CLINICAL UNITS AND EXPLAINS HOW THE ESSENCE OF THESE PRACTICES RELATES TO EACH OTHER. THE JUSTIFICATION OF THIS FUSION AS WELL AS DIFFERENCES BETWEEN THESE TWO MODALITIES ARE ALSO DESCRIBED AND EXPLAINED. WITHIN THE SCOPE OF THIS ARTICLE THE EXISTENCE OF SEVERAL SIMILARITIES BETWEEN THESE TWO PRACTICES HAS BEEN SUGGESTED FOR BOTH PRACTITIONERS AND RESEARCHERS. THEY CAN OBTAIN VALUABLE AND ADDITIONAL ARGUMENTS THROUGH CROSS-FERTILIZATION OF IDEAS ACROSS PRESENTED STUDIES UNITED BY SHARED, UNDERLYING BIOMECHANICAL CONCEPTS AND PHYSIOLOGICAL EFFECTS. SUCH CONCEPTUAL ENRICHMENT MAY BE A USEFUL SOURCE OF INSPIRATION FOR QIGONG AND YOGA PRACTITIONERS WHO TEND TO PREVENT LBP AND THERAPISTS (PHYSIOTHERAPISTS, OCCUPATIONAL THERAPISTS, REHABILITANTS, NURSES, BODYWORK AND MOVEMENT THERAPISTS OR MASSAGE THERAPISTS) INTENDED TO MANAGE THEIR PATIENTS' BACK PAINS AND OVERALL HEALTH ON A DAILY BASIS. 2011