1 1012 152 EFFECTS OF ONE MONTH OF COMMON YOGA PROTOCOL PRACTICE APPEAR TO BE MEDIATED BY THE ANGIOGENIC AND NEUROGENIC PATHWAY: A PILOT STUDY. OBJECTIVE: TO EXAMINE THE MOLECULAR EFFECTS OF MINDFUL ACTIVITIES SUCH AS YOGA AND MEDITATION DESIGN: THIS WAS AN OPEN LABEL SINGLE ARM EXPLORATORY YOGA INTERVENTION STUDY. STUDY PARTICIPANTS: 64 HEALTHY INDIVIDUALS WITHIN THE AGE OF 18-60 YEARS WERE RECRUITED FOR THIS ONE MONTH YOGA INTERVENTION STUDY. INTERVENTION: COMMON YOGA PROTOCOL (CYP) IS A STANDARDIZED YOGA PROTOCOL RELEASED BY MINISTRY OF AYUSH, INDIA FOR INTERNATIONAL YOGA DAY. IT INCLUDES ALL ASPECTS OF YOGA I.E. ASANAS, PRANAYAMA AND MEDITATION. IT IS DESIGNED FOR ADOPTION BY ALL AGE GROUPS FOR THE HEALTH OF COMMUNITY. OUTCOME MEASURES: THE PARTICIPANTS WERE ASSESSED FOR BIOCHEMICAL PARAMETERS INCLUDING FASTING SUGAR AND LIPID PROFILE. THE MOLECULAR MARKERS OF NEUROGENESIS (I.E. BRAIN DERIVED NEUROTROPIC FACTOR, BDNF) AND ANGIOGENESIS (I.E. VASCULAR ENDOTHELIAL GROWTH FACTOR, VEGF AND ANGIOGENIN) ALONG WITH AMYLOID BETA (MARKER RELATED TO NEURO-DEGENERATIVE DISEASES) WERE ASSESSED. ALL THE ASSESSMENTS WERE MADE AT BASELINE AND AFTER ONE MONTH OF THE INTERVENTION. RESULTS: AFTER ONE MONTH OF CYP PRACTICE HIGH DENSITY LIPOPROTEIN (HDL) LEVELS INCREASED SIGNIFICANTLY (P<0.001), ALTHOUGH OTHER BIOCHEMICAL PARAMETERS I.E. FASTING SUGAR AND OTHER LIPID ASSESSMENTS WERE FOUND TO BE UNALTERED. ANGIOGENESIS MARKER, ANGIOGENIN WAS INCREASED SIGNIFICANTLY (P<0.002), OTHER ANGIOGENESIS MARKER VEGF DID NOT SHOW ANY CHANGE ALONG WITH BDNF, MARKER OF NEUROGENESIS. AMYLOID BETA LEVELS WERE ALSO UNALTERED. EVEN THOUGH INDIVIDUAL LEVELS OF VEGF AND AMYLOID BETA DID NOT SHOW ANY CHANGE, PROPORTION OF VEGF TO AMYLOID BETA SHOWED A SIGNIFICANT INCREASE (P<0.001) AFTER ONE MONTH OF CYP INTERVENTION INDICATING THAT THE CHANGE IN VEGF LEVELS WAS SIGNIFICANTLY HIGHER THAN THE CHANGE IN AMYLOID BETA LEVELS. CONCLUSION: CYP PRACTICE MAY INFLUENCE CELL SURVIVAL PATHWAYS MEDIATED BY ANGIOGENIC AND NEUROGENIC CROSS TALK. HENCE, CYP CAN BE CONSIDERED AS A PREVENTIVE MEASURE FOR DISEASES ASSOCIATED WITH IMPAIRED ANGIOGENIC AND NEUROGENIC MECHANISM. THIS IS THE FIRST STUDY TO EXAMINE THE EFFECTS OF CYP AT THE MOLECULAR LEVEL. 2021 2 2153 34 THE EFFECTS OF SUDARSHAN KRIYA YOGA ON SOME PHYSIOLOGICAL AND BIOCHEMICAL PARAMETERS IN MILD HYPERTENSIVE PATIENTS. AN OPEN LABEL INTERVENTION STUDY WAS UNDERTAKEN ON 26 MILD HYPERTENSIVES AND 26 APPARENTLY HEALTHY ADULTS (30-60 Y), FOR THE EFFECT OF SUDARSHAN KRIYA YOGA PRACTICE FOR TWO MONTHS AS COMPLEMENTARY THERAPY. IN THE HYPERTENSIVES, THERE WAS A SIGNIFICANT DECREASE IN DIASTOLIC BLOOD PRESSURE (P < 0.01), SERUM UREA (P < 0.01) AND PLASMA MDA (MALONDIALDEHYDE ADDUCTS) AS OXIDATIVE STRESS MARKER (P < 0.05). OTHER PARAMETERS; VIZ.; PLASMA LEVELS OF CHOLESTEROL, TRIGLYCERIDES, GLUCOSE, DID NOT CHANGE SIGNIFICANTLY (P > 0.1). THE PATTERN OF CHANGE IN MOST OF THE STUDY PARAMETERS WAS SUCH THAT VALUES ABOVE NORMAL RANGE WERE LOWERED BUT VALUES WITHIN NORMAL RANGE WERE UNALTERED. THE ACTION OF YOGA ON DIASTOLIC BLOOD PRESSURE, MALONDIALDEHYDE ADDUCTS AND KIDNEY FUNCTION IN HYPERTENSIVES WAS OF COUNTERACTIVE NATURE AND FELT TO BE DISTINCTLY DIFFERENT THAN THE EFFECT OF DRUGS. 2011 3 138 26 A PRELIMINARY REPORT ON THE ROLE OF YOGA ASANAS ON OXIDATIVE STRESS IN NON-INSULIN DEPENDENT DIABETES MELLITUS. NINETEEN SUBJECTS OF NON-INSULIN DEPENDENT DIABETES MELLITUS (NIDDM) BETWEEN THE AGE GROUP OF 30-60 YRS WERE STUDIED TO SEE THE EFFECT OF SPECIFIC YOGA ASANAS ON FASTING AND POSTPRANDIAL BLOOD GLUCOSE (FBG, PPG), SERUM MALONDIALDEHYDE (MDA) AND GLYCOSYLATED HEMOGLOBIN (HBA(1)) IN ADDITION TO DRUG TREATMENT AND DIET CONTROL. THE DURATION OF DIABETES RANGED FROM 1-10 YEARS. PATIENTS WITH RENAL, CARDIAC AND PROLIFERATIVE RETINAL DISEASES WERE EXCLUDED FROM THE STUDY. THE SAME PATIENTS SERVED AS THEIR OWN CONTROL. SUBJECTS WERE CALLED IN THE MORNING TO THE CARDIO-RESPIRATORY LABORATORY AND WERE GIVEN TRAINING BY A YOGA EXPERT. YOGA ASANAS INCLUDED SURYANAMSKAR, TADASAN, TRIKONASAN, PADMASAN, PRANAYAM, PASCHIMOTTANASAN, ARDHMATSYENDRASAN, PAVANMUKTHASAN, SARPASAN AND SHAVASAN. THE ASANAS WERE DONE EVERY DAY FOR 40 DAYS FOR 30-40 MIN. FBG, PPG, SERUM MDA AND HBA(1) WERE ESTIMATED BEFORE AND AFTER 40 DAYS OF YOGA ASANAS REGIMEN. SIGNIFICANT REDUCTION WAS SEEN IN FBG FROM 220 MG/DL TO 162 MG/DL, PPG FROM 311 MG/DL TO 255 MG/DL, MDA FROM 6 NMOL/L TO 3 NMOL/L AND HBA(1), FROM 8.8% TO 6.4%. SUBJECTS FELT BETTER AND WERE RELIEVED OF THEIR STRESSES AND HAD AN IMPROVEMENT IN THEIR DAY TO DAY PERFORMANCE. THE DECREASE WAS STATISTICALLY SIGNIFICANT (P<0.0001 FOR FBG AND PPG, P<0.001 FOR MDA AND FOR HBA(1)). 2001 4 2463 41 YOGA AS A THERAPEUTIC INTERVENTION FOR THE MANAGEMENT OF TYPE 2 DIABETES MELLITUS. PURPOSE: THIS STUDY AIMED TO INVESTIGATE THE EFFECTS OF 12 WEEKS YOGIC INTERVENTION ON BLOOD SUGAR AND LIPID PROFILE IN ELDER WOMEN WITH TYPE 2 DIABETES MELLITUS (T2DM). SUBJECTS AND METHODS: TWENTY ELDERLY (AGE RANGE 55-70 YEARS) T2DM WOMEN WERE DIVIDED INTO TWO GROUPS, NAMELY, YOGIC INTERVENTION GROUP (YIG: N = 10, AGE 64.70 +/- 4.03, BODY MASS INDEX [BMI] 24.26 +/- 3.40) AND CONTROL GROUP (CG: N = 10, AGE 64.40 +/- 4.79, BMI 24.28 +/- 2.36). YIG UNDERWENT YOGA PRACTICE (ASANAS, KRIYAS, PRANAYAMAS) FOR 12 WEEKS (3 SESSIONS/WEEK), WHILE THE CG CONTINUED THEIR USUAL ROUTINE ACTIVITIES. STANDING HEIGHT, BODY WEIGHT, BMI, BLOOD SUGAR, AND LIPID PROFILE WERE MEASURED BEFORE COMMENCEMENT AND AFTER 6 AND 12 WEEKS OF YOGIC INTERVENTION IN BOTH GROUPS. RESULTS: THERE WAS A SIGNIFICANT (P < 0.01) DECREASE IN FASTING PLASMA GLUCOSE, POSTPRANDIAL BLOOD SUGAR, TOTAL CHOLESTEROL, TRIGLYCERIDES, LOW-DENSITY LIPOPROTEIN, AND VERY LOW DENSITY LIPOPROTEIN, WITH A SIGNIFICANT (P < 0.01) INCREASE IN HIGH-DENSITY LIPOPROTEIN LEVEL FROM ITS INITIAL VALUE IN YIG, WHILE SHOWING INSIGNIFICANT RESULT IN CG. CONCLUSION: IT CAN BE SAID THAT YOGIC INTERVENTION MAY HAVE THE BENEFICIAL EFFECTS ON BLOOD SUGAR AND LIPID PROFILE IN ELDERLY WOMEN WITH T2DM. 2018 5 1392 37 IMPACT OF YOGA AND MEDITATION ON CELLULAR AGING IN APPARENTLY HEALTHY INDIVIDUALS: A PROSPECTIVE, OPEN-LABEL SINGLE-ARM EXPLORATORY STUDY. THIS STUDY WAS DESIGNED TO EXPLORE THE IMPACT OF YOGA AND MEDITATION BASED LIFESTYLE INTERVENTION (YMLI) ON CELLULAR AGING IN APPARENTLY HEALTHY INDIVIDUALS. DURING THIS 12-WEEK PROSPECTIVE, OPEN-LABEL, SINGLE ARM EXPLORATORY STUDY, 96 APPARENTLY HEALTHY INDIVIDUALS WERE ENROLLED TO RECEIVE YMLI. THE PRIMARY ENDPOINTS WERE ASSESSMENT OF THE CHANGE IN LEVELS OF CARDINAL BIOMARKERS OF CELLULAR AGING IN BLOOD FROM BASELINE TO WEEK 12, WHICH INCLUDED DNA DAMAGE MARKER 8-HYDROXY-2'-DEOXYGUANOSINE (8-OH2DG), OXIDATIVE STRESS MARKERS REACTIVE OXYGEN SPECIES (ROS), AND TOTAL ANTIOXIDANT CAPACITY (TAC), AND TELOMERE ATTRITION MARKERS TELOMERE LENGTH AND TELOMERASE ACTIVITY. THE SECONDARY ENDPOINTS WERE ASSESSMENT OF METABOTROPHIC BLOOD BIOMARKERS ASSOCIATED WITH CELLULAR AGING, WHICH INCLUDED CORTISOL, BETA-ENDORPHIN, IL-6, BDNF, AND SIRTUIN-1. AFTER 12 WEEKS OF YMLI, THERE WERE SIGNIFICANT IMPROVEMENTS IN BOTH THE CARDINAL BIOMARKERS OF CELLULAR AGING AND THE METABOTROPHIC BIOMARKERS INFLUENCING CELLULAR AGING COMPARED TO BASELINE VALUES. THE MEAN LEVELS OF 8-OH2DG, ROS, CORTISOL, AND IL-6 WERE SIGNIFICANTLY LOWER AND MEAN LEVELS OF TAC, TELOMERASE ACTIVITY, BETA-ENDORPHIN, BDNF, AND SIRTUIN-1 WERE SIGNIFICANTLY INCREASED (ALL VALUES P < 0.05) POST-YMLI. THE MEAN LEVEL OF TELOMERE LENGTH WAS INCREASED BUT THE FINDING WAS NOT SIGNIFICANT (P = 0.069). YMLI SIGNIFICANTLY REDUCED THE RATE OF CELLULAR AGING IN APPARENTLY HEALTHY POPULATION. 2017 6 2056 33 THE BENEFICIAL EFFECT OF YOGA IN DIABETES. TWENTY NIDDM SUBJECTS (MILD TO MODERATE DIABETICS) IN THE AGE GROUP OF 30-60 YEARS WERE SELECTED FROM THE OUT PATIENT CLINIC OF G.T.B. HOSPITAL. THEY WERE ON A 40 DAYS YOGA ASANA REGIME UNDER THE SUPERVISION OF A YOGA EXPERT. 13 SPECIFIC YOGA ASANAS < OR = DONE BY TYPE 2 DIABETES PATIENTS INCLUDED. SURYA NAMASKAR, TRIKONASANA, TADASANA, SUKHASANA, PADMASANA, BHASTRIKA PRANAYAMA, PASHIMOTTANASANA, ARDHMATSYENDRASANA, PAWANMUKTASANA, BHUJANGASANA, VAJRASANA, DHANURASANA AND SHAVASANA ARE BENEFICIAL FOR DIABETES MELLITUS. SERUM INSULIN, PLASMA FASTING AND ONE HOUR POSTPRANDIAL BLOOD GLUCOSE LEVELS AND ANTHROPOMETRIC PARAMETERS WERE MEASURED BEFORE AND AFTER YOGA ASANAS. THE RESULTS INDICATE THAT THERE WAS SIGNIFICANT DECREASE IN FASTING GLUCOSE LEVELS FROM BASAL 208.3 +/- 20.0 TO 171.7 +/- 19.5 MG/DL AND ONE HOUR POSTPRANDIAL BLOOD GLUCOSE LEVELS DECREASED FROM 295.3 +/- 22.0 TO 269.7 +/- 19.9 MG/DL. THE EXACT MECHANISM AS TO HOW THESE POSTURES AND CONTROLLED BREATHING INTERACT WITH SOMATOENDOCRINE MECHANISM AFFECTING INSULIN KINETICS WAS WORKED OUT. A SIGNIFICANT DECREASE IN WAIST-HIP RATIO AND CHANGES IN INSULIN LEVELS WERE ALSO OBSERVED, SUGGESTING A POSITIVE EFFECT OF YOGA ASANAS ON GLUCOSE UTILISATION AND FAT REDISTRIBUTION IN NIDDM. YOGA ASANAS MAY BE USED AS AN ADJUNCT WITH DIET AND DRUGS IN THE MANAGEMENT OF TYPE 2 DIABETES. 2005 7 791 35 EFFECT OF YOGA EXERCISE THERAPY ON OXIDATIVE STRESS INDICATORS WITH END-STAGE RENAL DISEASE ON HEMODIALYSIS. BACKGROUND: OXIDATIVE STRESS PROMOTES ENDOTHELIAL DYSFUNCTION AND ATHEROSCLEROSIS IN CHRONIC RENAL DISEASE. OBJECTIVES: THIS STUDY INVESTIGATED THE IMPACT OF HATHA YOGA ON OXIDATIVE STRESS INDICATORS AND OXIDANT STATUS, IN PATIENTS WITH END-STAGE RENAL DISEASE (ESRD) ON HEMODIALYSIS. DESIGN: THIS PROSPECTIVE RANDOMIZED STUDY CONSISTED OF 33 ESRD PATIENTS IN THE HATHA YOGA EXERCISE GROUP WHO WERE MATCHED WITH 35 ESRD PATIENTS IN THE CONTROL GROUP. OUTCOME MEASURES: THE OXIDATIVE STRESS INDICATORS (MALONDIALDEHYDE - MDA, PROTEIN OXIDATION - POX, PHOSPHOLIPASE A2 - PLA2 ACTIVITY) AND THE OXIDATIVE STATUS (SUPEROXIDE DISMUTASE (SOD) AND CATALASE ACTIVITIES) WERE DETERMINED IN THE BLOOD SAMPLES TAKEN AT THE PRE-HEMODIALYSIS TREATMENT, AT BASELINE (0 MONTHS) AND AFTER FOUR MONTHS. RESULTS: IN PATIENTS IN THE HATHA YOGA EXERCISE GROUP, LIPID PEROXIDATION, AS INDICATED BY MDA DECREASED BY 4.0% AFTER FOUR MONTHS (P = 0.096). THERE WAS ALSO A SIGNIFICANT REDUCTION IN THE ACTIVITY OF PLA FROM 2.68 +/- 0.02 IU / L TO 2.34 IU / L (- 12.7%; P = 0.010) AND POX FROM 2.28 +/- 0.02 NMOL / MG TO 2.22 +/- 0.01 NMOL / MG (- 22.6%; P = 0.0001). THE ACTIVITY OF SOD SIGNIFICANTLY INCREASED FROM 12.91 +/- 0.17 U / L TO 13.54 +/- 0.15 U / L (4.65%; P = 0.0001) AND CATALASE FROM 79.83 +/- 0.63 U / L TO 80.54 +/- 0.80 U / L (0.90%; P = 0.0001). THERE WAS A SIGNIFICANT CORRELATION BETWEEN THE PRE-HEMODIALYSIS OXIDATIVE STRESS PARAMETERS AT THE ZERO MONTH AND AFTER FOUR MONTHS FOR THE ACTIVITIES OF PLA (R = 0.440), CATALASE (R = 0.872), AND SOD (R = 0.775). CONCLUSIONS: THESE FINDINGS SUGGEST THAT THE HATHA YOGA EXERCISE HAS THERAPEUTIC, PREVENTATIVE, AND PROTECTIVE EFFECTS IN ESRD SUBJECTS, BY DECREASING OXIDATIVE STRESS. 2013 8 839 28 EFFECT OF YOGA ON PLASMA GLUCOSE, LIPID PROFILE, BLOOD PRESSURE AND INSULIN REQUIREMENT IN A PATIENT WITH TYPE 1 DIABETES MELLITUS. OBJECTIVES: THE OBJECTIVE OF THE STUDY IS TO EVALUATE THE SHORT-TERM EFFECT OF YOGA ON PLASMA GLUCOSE, LIPID PROFILE, BLOOD PRESSURE AND INSULIN REQUIREMENT IN A PATIENT WITH TYPE 1 DIABETES MELLITUS (T1DM). CASE PRESENTATION: A 28-YEARS OLD FEMALE WAS DIAGNOSED WITH T1DM AT THE AGE OF SEVEN. SHE WAS UNDER HUMAN MIXTARD INSULIN 30-70, THRICE/DAY FOR 15-15-15 UNITS. SHE HAD A HISTORY OF POOR GLYCEMIC CONTROL, DIABETIC KETOACIDOSIS AND HYPOGLYCEMIC SHOCK. AT THE AGE OF 27, SHE GOT ADMITTED WITH COMPLAINTS OF GENERAL WEAKNESS, JOINTS STIFFNESS AND WEIGHT LOSS IN OUR HOLISTIC HEALTH CENTRE AND UNDERWENT TWO WEEKS OF YOGA. RESULTS SHOWED A BETTER REDUCTION IN THE PLASMA GLUCOSE LEVELS, LIPID PROFILE, BLOOD PRESSURE AND INSULIN DOSE AND AN INCREASE IN HEMOGLOBIN LEVELS WITH NO EPISODES OF HYPOGLYCEMIA AFTER YOGA. CONCLUSIONS: YOGA MIGHT BE CONSIDERED AS A SAFER AND EFFECTIVE ADJUVANT IN THE MANAGEMENT OF T1DM. 2021 9 213 23 A STUDY OF RESPONSE PATTERN OF NON-INSULIN DEPENDENT DIABETICS TO YOGA THERAPY. CHANGES IN BLOOD GLUCOSE AND GLUCOSE TOLERANCE BY ORAL GLUCOSE TOLERANCE TEST (OGTT) AFTER 40 DAYS OF YOGA THERAPY IN 149 NON-INSULIN-DEPENDENT DIABETICS (NIDDM) WERE INVESTIGATED. THE RESPONSE TO YOGA IN THESE SUBJECTS WAS CATEGORIZED ACCORDING TO A SEVERITY SCALE INDEX (SSI) BASED ON AREA INDEX TOTAL (AIT) UNDER OGTT CURVE. ONE HUNDRED AND FOUR PATIENTS SHOWED A FAIR TO GOOD RESPONSE TO THE YOGA THERAPY. THERE WAS A SIGNIFICANT REDUCTION IN HYPERGLYCEMIA AND AIT WITH DECREASE IN ORAL HYPOGLYCEMIA AND AIT WITH DECREASE IN ORAL HYPOGLYCEMIC DRUGS REQUIRED FOR MAINTENANCE OF NORMOGLYCEMIA. IT IS CONCLUDED THAT YOGA, A SIMPLE AND ECONOMICAL THERAPY, MAY BE CONSIDERED A BENEFICIAL ADJUVANT FOR NIDDM PATIENTS. 1993 10 1453 35 INFLUENCE OF PRANAYAMAS AND YOGA-ASANAS ON SERUM INSULIN, BLOOD GLUCOSE AND LIPID PROFILE IN TYPE 2 DIABETES. A DISTINGUISHABLE FEATURE OF TYPE 2 DIABETES BESIDES HYPERGLYCEMIA AND DERANGED LIPID PROFILE IS AN IMPAIRED INSULIN SECRETION, PERIPHERAL INSULIN RESISTANCE AND OBESITY WHICH HAS BECOME A MAJOR HEALTH CONCERN WORLDWIDE. INDIA WITH AN ESTIMATED 31MILLION DIABETICS IN 2000 AND 79MLLIONS BY THE YR 2030 HAS THE HIGHEST NUMBER OF TYPE 2 DIABETICS IN THE WORLD. IN THIS STUDY, WE AIMED TO SEE IF YOGA-ASANAS AND PRANAYAMAS HAVE ANY INFLUENCE IN MODIFYING CERTAIN BIOCHEMICAL PARAMETERS. SIXTY PATIENTS OF UNCOMPLICATED TYPE 2 DIABETES (AGE 35-60 YRS OF 1-10 YRS DURATION) WERE DIVIDED INTO TWO GROUPS: GROUP 1 (N=30): PERFORMED YOGA ALONG WITH THE CONVENTIONAL HYPOGLYCEMIC MEDICINES AND GROUP 2 (N=30): PATIENTS WHO ONLY RECEIVED CONVENTIONAL MEDICINES. DURATION OF THE STUDY WAS 45 DAYS. BASAL RECORDINGS OF BLOOD GLUCOSE (FASTING AND POST-PRANDIAL), LIPID PROFILE AND SERUM INSULIN WERE TAKEN AT THE TIME OF RECRUITMENT AND THE SECOND READING AFTER FORTY FIVE DAYS. RESULTS SHOWED A SIGNIFICANT IMPROVEMENT IN ALL THE BIOCHEMICAL PARAMETERS IN GROUP 1 WHILE GROUP 2 SHOWED SIGNIFICANT IMPROVEMENT IN ONLY FEW PARAMETERS, THUS SUGGESTING A BENEFICIAL EFFECT OF YOGA REGIMEN ON THESE PARAMETERS IN DIABETIC PATIENTS. 2008 11 359 37 ASSOCIATION OF LEUKOCYTE TELOMERE LENGTH WITH OXIDATIVE STRESS IN YOGA PRACTITIONERS. OBJECTIVE: YOGA IS A MIND-BODY MODULATION TECHNIQUE THAT HAS BEEN SHOWN TO HAVE BENEFICIAL EFFECTS ON VARIOUS DISEASES RELATED TO VARIOUS SYSTEMS IN THE BODY. HOWEVER, THE MOLECULAR BASIS OF MECHANISM OF ACTION IS NOT CLEAR. HENCE, THIS STUDY WAS DESIGNED TO STUDY THE LEUKOCYTE TELOMERE BIOLOGY AND ITS RELATION WITH HOMOCYSTEINE AND OXIDATIVE STRESS IN YOGA PRACTITIONERS. MATERIALS AND METHODS: THIS IS A PROSPECTIVE CASE-CONTROL STUDY INVOLVING YOGA PRACTITIONERS AGED 30-40 Y WITH MINIMUM OF TWO YEARS YOGA PRACTICE (YOGA GROUP) AND AGE, GENDER AND BODY MASS INDEX MATCHED SEDENTARY HEALTHY GENERAL POPULATION WITH NO MEDICAL PROBLEMS (CONTROL GROUP). LEUKOCYTE TELOMERE LENGTH (LTL) WAS MEASURED BY USING QUANTITATIVE PCR (QPCR), FASTING PLASMA HOMOCYSTEINE WAS MEASURED BY A RAPID HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY ASSAY AND THE OXIDATIVE STRESS WAS ASSESSED WITH TOTAL ANTIOXIDANT STATUS (TAOS), MALONDIALDEHYDE (MDA) MEASURED BY CALORIMETRY. RESULTS: THE LTL WAS SHORTER IN CONTROL GROUP THAN IN YOGA GROUP (P<0.001). THE TAOS WAS MORE IN YOGA GROUP WHEN COMPARED TO CONTROL GROUP (P=0.008), MDA AND HOMOCYSTEINE WAS HIGH IN CONTROL GROUP WHEN COMPARED TO YOGA GROUP (P<0.001). FURTHER, THE LTL WAS POSITIVELY CORRELATED WITH TAOS (R=0.841, P<0.001) AND NEGATIVELY CORRELATED WITH MDA (R=-0.931, P<0.001) AND HOMOCYSTEINE (R=-0.756, P<0.001). CONCLUSION: THE LTL IS WELL-PRESERVED IN PEOPLE WHO PRACTICE YOGA REGULARLY WITH LOWER SYSTEMIC OXIDATIVE STRESS COMPARED TO THOSE WHO HAVE A RELATIVELY SEDENTARY LIFESTYLE DESPITE LACK OF ANY MEDICAL DISORDERS. THE HABITUAL YOGA PRACTICE SEEMS TO INHIBIT REPLICATIVE CELLULAR SENESCENCE. 2015 12 913 42 EFFECTIVENESS OF LIQUID FASTING WITH YOGA AND NATUROPATHY TREATMENTS IN REDUCING METABOLIC AND CARDIOVASCULAR RISKS IN OBESITY. CONTEXT: OBESITY IS ASSOCIATED WITH CHRONIC DISEASES, INCLUDING METABOLIC SYNDROME AND CARDIOVASCULAR DISEASES (CVDS). FASTING IS COMMONLY EMPLOYED BY OBESE PEOPLE TO REDUCE THEIR WEIGHT. LIKEWISE, YOGA AND NATUROPATHY (YN) THAT INCLUDE LIQUID FASTING (LF) HAVE BEEN SHOWN TO BE BENEFICIAL IN REDUCING WEIGHT FOR PEOPLE WITH METABOLIC DISORDERS. HOWEVER, THE SAFETY OF LF DURING YN TREATMENTS AND ITS EFFECTS ON METABOLIC AND CARDIOVASCULAR RISK FACTORS HAVEN'T YET BEEN REPORTED. OBJECTIVE: THE STUDY INTENDED TO EVALUATE THE SAFETY OF LF DURING YN TREATMENTS AND ITS EFFECTS ON METABOLIC AND CARDIOVASCULAR RISK FACTORS IN PEOPLE WITH OBESITY. DESIGN: A SINGLE-GROUP, PRETEST-AND-POSTTEST DESIGN WAS ADOPTED FOR THE STUDY. SETTING: THE STUDY TOOK PLACE IN A YN HOSPITAL LOCATED IN SOUTH INDIA. PARTICIPANTS: PARTICIPANTS WERE 176 OBESE PEOPLE AGED BETWEEN 18 AND 65 YEARS. INTERVENTION: TOGETHER WITH YN TREATMENTS, ALL PARTICIPANTS UNDERWENT LF USING LIME JUICE WITH JAGGERY, ASH GUARD JUICE, VEGETABLE SOUP, BUTTERMILK, AND KOKUM JUICE FOR A PERIOD OF 5 CONSECUTIVE DAYS. OUTCOME MEASURES: ASSESSMENTS SUCH AS BODY WEIGHT, BODY MASS INDEX (BMI), FAT MASS, LIPID PROFILE, AND BLOOD PRESSURE WERE TAKEN AT BASELINE AND POSTINTERVENTION. RESULTS: PARTICIPANTS SHOWED A SIGNIFICANT REDUCTION IN BODY WEIGHT, BMI, FAT MASS, TRIGLYCERIDES (TG), TOTAL CHOLESTEROL (TC), LOW-DENSITY LIPOPROTEIN CHOLESTEROL (LDL-C), VERY-LOW-DENSITY LIPOPROTEIN CHOLESTEROL (VLDL-C), HIGH-DENSITY LIPOPROTEIN CHOLESTEROL (HDL-C), SYSTOLIC BLOOD PRESSURE (SBP), AND DIASTOLIC BLOOD PRESSURE (DBP). CONCLUSIONS: THE RESULTS SUGGEST THAT LF DURING YN TREATMENT CANBE EFFECTIVE IN REDUCING METABOLIC AND CARDIOVASCULAR RISK FACTORS IN PEOPLE WITH OBESITY. 2021 13 833 39 EFFECT OF YOGA ON OXIDATIVE STRESS IN ELDERLY WITH GRADE-I HYPERTENSION: A RANDOMIZED CONTROLLED STUDY. BACKGROUND AND OBJECTIVES: HYPERTENSION, ESPECIALLY IN ELDERLY IS A STRONG RISK FACTOR FOR CARDIOVASCULAR MORTALITY AND MORBIDITY. OXIDATIVE STRESS HAS BEEN IMPLICATED AS ONE OF THE UNDERLYING CAUSE OF HYPERTENSION. YOGA HAS BEEN FOUND TO CONTROL HYPERTENSION IN THE ELDERLY, BUT THE UNDERLYING BENEFITS OF MECHANISM IN RELATION TO OXIDATIVE STRESS REGULATION REMAINS UNCLEAR. THE PURPOSE OF THE STUDY WAS TO INVESTIGATE THE EFFECT OF YOGA ON OXIDATIVE STRESS IN ELDERLY WITH GRADE-I HYPERTENSION. METHODS: AN OPEN PARALLEL-ARM RANDOMISED CONTROLLED STUDY WAS CONDUCTED AT BLDE UNIVERSITY'S SHRI B.M.PATIL MEDICAL COLLEGE, HOSPITAL AND RESEARCH CENTRE, INDIA ON ELDERLY MALE INDIVIDUALS WITH GRADE-I HYPERTENSION (N=57, AGE 60-80 YEARS). STUDY (YOGA) GROUP WAS ASSIGNED FOR YOGA INTERVENTION AND CONTROL GROUP FOR WALKING FOR ONE HOUR IN THE MORNING FOR SIX DAYS IN A WEEK FOR THREE MONTHS UNDER THE SUPERVISION OF YOGA INSTRUCTOR AND PHYSICAL TRAINING INSTRUCTOR RESPECTIVELY. SERUM MALONDIALDEHYDE (MDA) AS AN INDICATOR OF OXIDATIVE STRESS AND ANTIOXIDANTS SUCH AS SERUM SUPEROXIDE DISMUTASE (SOD), REDUCED GLUTATHIONE (GSH) AND VITAMIN C LEVELS WERE ESTIMATED. RESULTS: YOGA PRACTICE FOR THREE MONTHS HAS SIGNIFICANTLY REDUCED SERUM MDA LEVEL (P<0.001), AND ENHANCED ANTIOXIDANTS LEVEL SUCH AS SOD ACTIVITY (P=0.007), SERUM GSH (P=0.002) AND VITAMIN C (P=0.002). IN THE CONTROL GROUP, WE OBSERVED A SIGNIFICANT INCREASE IN SERUM MDA LEVEL (P=0.04) AND REDUCTION IN SERUM VITAMIN C LEVEL (P=0.015) WITH NO SIGNIFICANT DIFFERENCE IN THE SOD ACTIVITY AND GSH LEVEL. CONCLUSION: THESE FINDINGS SUGGEST THAT YOGA IS AN EFFECTIVE MEANS TO REDUCE OXIDATIVE STRESS AND TO IMPROVE ANTIOXIDANT DEFENSE IN ELDERLY HYPERTENSIVE INDIVIDUALS. 2014 14 1971 39 SHORT-TERM EFFECT OF ADD ON BELL PEPPER (CAPSICUM ANNUUM VAR. GROSSUM) JUICE WITH INTEGRATED APPROACH OF YOGA THERAPY ON BLOOD GLUCOSE LEVELS AND CARDIOVASCULAR FUNCTIONS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS: A RANDOMIZED CONTROLLED STUDY. BACKGROUND: TYPE 2 DIABETES MELLITUS (T2DM) IS A MAJOR GLOBAL HEALTH PROBLEM. THOUGH VARIOUS STUDIES HAVE REPORTED THE BENEFICIAL EFFECT OF YOGA IN PATIENT WITH T2DM, THERE IS A LACK OF STUDY IN COMBINATION WITH BELL PEPPER AND YOGA. HENCE, THE PRESENT STUDY AIMS AT EVALUATING SHORT-TERM EFFECT OF ADD ON BELL PEPPER JUICE WITH INTEGRATED APPROACH OF YOGA THERAPY (IAYT) ON BLOOD GLUCOSE LEVELS AND CARDIOVASCULAR VARIABLES IN PATIENTS WITH T2DM. MATERIALS AND METHODS: FIFTY T2DM SUBJECTS WITH THE AGE VARIED FROM 34 TO 69-YEARS WERE RECRUITED AND RANDOMLY DIVIDED INTO EITHER STUDY GROUP OR CONTROL GROUP. THE STUDY GROUP RECEIVED 100-ML OF BELL PEPPER JUICE (TWICE/DAY) ALONG WITH IAYT WHILE THE CONTROL GROUP RECEIVED ONLY IAYT FOR 4-CONSECUTIVE DAYS. BASELINE AND POST-TEST ASSESSMENTS WERE TAKEN BEFORE AND AFTER THE INTERVENTION. STATISTICAL ANALYSIS WAS PERFORMED USING STATISTICAL PACKAGE FOR THE SOCIAL SCIENCES, VERSION-16. RESULTS: RESULTS OF THIS STUDY SHOWED NO SIGNIFICANT DIFFERENCE IN OVERALL (FASTING AND POST PRANDIAL) BLOOD GLUCOSE LEVEL IN THE STUDY GROUP COMPARED WITH CONTROL GROUP. HOWEVER, A SIGNIFICANT REDUCTION IN POST PRANDIAL BLOOD GLUCOSE (PPBG), SYSTOLIC BLOOD PRESSURE (SBP), PULSE PRESSURE (PP), RATE PRESSURE PRODUCT (RPP) AND DOUBLE PRODUCT (DO-P) WAS OBSERVED IN THE STUDY GROUP COMPARED WITH CONTROL GROUP. CONCLUSION: RESULTS OF THIS STUDY SUGGEST THAT THOUGH AN ADDITION OF 100-ML OF BELL PEPPER JUICE (TWICE/DAY) ALONG WITH IAYT IS NOT MORE EFFECTIVE IN REDUCING FASTING BLOOD GLUCOSE, IT MAY BE MORE EFFECTIVE IN REDUCING PPBG, SBP, PP, RPP AND DO-P THAN IAYT ALONE. 2017 15 1634 38 MODELING THE EFFECTS OF YOGA ON THE PROGRESSION OF ALZHEIMER'S DISEASE IN A DISH. ALZHEIMER'S DISEASE (AD) ACCOUNTS FOR 80% OF ALL DEMENTIA CASES, MAKING IT THE MOST COMMON FORM OF DEMENTIA. AGING SERVES AS THE MAIN RISK FACTOR FOR AD, BUT EARLY ONSET AD CAN ALSO OCCUR IN INDIVIDUALS YOUNGER THAN 65 YEARS. AD RESULTS FROM PROGRESSIVE NEURODEGENERATION LEADING TO DYSFUNCTIONAL SYNAPTIC TRANSMISSION IN THE BRAIN. THE CASCADE HYPOTHESIS OF AD STATES THAT AMYLOID PRECURSOR PROTEIN (APP) METABOLISM BECOMES IMPAIRED EITHER BY MUTATION OR AN INTERLEUKIN-MEDIATED STRESS RESPONSE TO INJURY, RESULTING IN THE SPLICING OF HARMFUL OLIGOMERIC FORMS OF AMYLOID BETA (ABETA). THESE OLIGOMERS DISRUPT EXTRACELLULAR RECEPTOR BINDING, INTRACELLULAR FUNCTION, AND CELLULAR MEMBRANE INTEGRITY. YOGA AND MEDITATIVE PRACTICES SLOW THE PROGRESSION OF THE COGNITIVE DECLINE ASSOCIATED WITH AD. HOWEVER, THE BIOLOGICAL MECHANISMS UNDERLYING THIS THERAPEUTIC EFFECT REMAIN ELUSIVE. HERE, WE INVESTIGATED THE ABILITY OF NEUROTRANSMITTERS RELEASED DURING YOGA AND MEDITATIVE PRACTICES TO RESCUE NEURONS FROM SYNAPTIC DYSFUNCTION IN AN IN VITRO ALZHEIMER'S MODEL CREATED BY CULTURING BASAL FOREBRAIN CHOLINERGIC NEURONS WITH PHYSIOLOGICALLY RELEVANT LEVELS OF THE I-42 ISOFORM OF OLIGOMERIC ABETA (OALPHABETAI-42). WE FOUND THAT THE NEUROTRANSMITTERS DOPAMINE AND HISTAMINE PRODUCE A COOPERATIVE ACTION WITH SEROTONIN TO REVERSE THE LOSS OF CHOLINE ACETYLTRANSFERASE (CHAT) BY OALPHABETAI-42. THE LOSS OF CHAT, THE ENZYME RESPONSIBLE FOR PROCESSING THE CHOLINERGIC NEUROTRANSMITTER ACETYLCHOLINE, CONTRIBUTES TO THE SYNAPTIC DYSFUNCTION EXPERIENCED DURING AD. THESE NEUROTRANSMITTERS INHIBIT NITRIC OXIDE SYNTHESIS CAUSED BY OALPHABETAI-42, PREVENTING OXIDATIVE AND NITROSATIVE STRESS. SEROTONIN ACTIVATES AN ALTERNATE CLEAVAGE OF APP TO PRODUCE A FRAGMENT WITH KNOWN NEUROTROPHIC EFFECTS, GIVING IT THE UNIQUE ABILITY TO INHIBIT THE OALPHABETAI-42 PRODUCTION CYCLE. WE HYPOTHESIZE HERE THAT THESE CONCERTED ACTIONS LEAD TO THE PROTECTION OF CHOLINERGIC SYNAPTIC TRANSMISSION IN AD. 2018 16 437 34 CARDIOVASCULAR AND METABOLIC EFFECTS OF INTENSIVE HATHA YOGA TRAINING IN MIDDLE-AGED AND OLDER WOMEN FROM NORTHERN MEXICO. BACKGROUND: HATHA YOGA (HY) CAN BE AN ALTERNATIVE TO IMPROVE PHYSICAL ACTIVITY IN MIDDLE-AGED AND OLDER WOMEN. HOWEVER, CONVENTIONAL HY (CHY) EXERCISING MAY NOT RESULT IN ENOUGH TRAINING STIMULUS TO IMPROVE CARDIOVASCULAR FITNESS. THE PURPOSE OF THIS STUDY WAS TO EVALUATE THE EFFECT OF AN INTENSIVE HY INTERVENTION (IHY) ON CARDIOVASCULAR RISK FACTORS IN MIDDLE-AGED AND OLDER WOMEN FROM NORTHERN MEXICO. MATERIALS AND METHODS: IN THIS PROSPECTIVE QUASIEXPERIMENTAL DESIGN, FOUR MIDDLE-AGED AND NINE OLDER CHY PRACTICING FEMALES (YOGINIS) WERE ENROLLED INTO AN 11-WEEK IHY PROGRAM CONSISTING OF 5 SESSIONS/WEEK FOR 90 MIN (55 SESSIONS). THE PROGRAM ADHERENCE, ASANA PERFORMANCE, AND WORK INTENSITY WERE ASSESSED ALONG THE INTERVENTION. ANTHROPOMETRIC [BODY MASS INDEX (BMI), % BODY FAT AND SIGMA SKIN FOLDS], CARDIOVASCULAR FITNESS [MAXIMAL EXPIRED AIR VOLUME (VE(MAX)), MAXIMAL O(2) CONSUMPTION (VO(2MAX)), MAXIMAL HEART RATE (HR(MAX)), SYSTOLIC (BPS) AND DIASTOLIC BLOOD PRESSURE (BPD)], BIOCHEMICAL [GLUCOSE, TRIACYLGLYCEROLS (TAG), TOTAL CHOLESTEROL (TC), HIGH-DENSITY LIPOPROTEIN CHOLESTEROL (HDL-C), AND LOW-DENSITY LIPOPROTEIN CHOLESTEROL (LDL-C)], AND DIETARY PARAMETERS WERE EVALUATED BEFORE AND AFTER IHY. RESULTS: DAILY CALORIC INTAKE (~1,916 KCAL/DAY), PROGRAM ADHERENCE (~85%), AND EXERCISING SKILLS (ASANA PERFORMANCE) WERE SIMILAR IN BOTH MIDDLE-AGED AND OLDER WOMEN. THE IHY PROGRAM DID NOT MODIFY ANY ANTHROPOMETRIC MEASUREMENTS. HOWEVER, IT INCREASED VO(2MAX) AND VE(MAX) AND HDL-C WHILE TAG AND LDL-C REMAINED STABLE IN BOTH MIDDLE-AGED AND OLDER GROUPS (P < 0.01). CONCLUSIONS: THE PROPOSED IHY PROGRAM IMPROVES DIFFERENT CARDIOVASCULAR RISK FACTORS (NAMELY VO(2MAX) AND HDL-C) IN MIDDLE-AGED AND OLDER WOMEN. 2009 17 814 33 EFFECT OF YOGA ON CARDIOVASCULAR SYSTEM IN SUBJECTS ABOVE 40 YEARS. THIS STUDY WAS CONDUCTED TO EXAMINE THE EFFECT OF YOGA ON CARDIOVASCULAR FUNCTION IN SUBJECTS ABOVE 40 YRS OF AGE. PULSE RATE, SYSTOLIC AND DIASTOLIC BLOOD PRESSURE AND VALSALVA RATIO WERE STUDIED IN 50 CONTROL SUBJECTS (NOT DOING ANY TYPE OF PHYSICAL EXERCISE) AND 50 STUDY SUBJECTS WHO HAD BEEN PRACTICING YOGA FOR 5 YEARS. FROM THE STUDY IT WAS OBSERVED THAT SIGNIFICANT REDUCTION IN THE PULSE RATE OCCURS IN SUBJECTS PRACTICING YOGA (P<0.001). THE DIFFERENCE IN THE MEAN VALUES OF SYSTOLIC AND DIASTOLIC BLOOD PRESSURE BETWEEN STUDY GROUP AND CONTROL GROUP WAS ALSO STATISTICALLY SIGNIFICANT (P<0.01 AND P<0.001 RESPECTIVELY). THE SYSTOLIC AND DIASTOLIC BLOOD PRESSURE SHOWED SIGNIFICANT POSITIVE CORRELATION WITH AGE IN THE STUDY GROUP (R1 SYSTOLIC= 0.631 AND R1 DIASTOLIC = 0.610) AS WELL AS IN THE CONTROL GROUP (R2 SYSTOLIC = 0.981 AND R2 DIASTOLIC = 0.864). THE SIGNIFICANCE OF DIFFERENCE BETWEEN CORRELATION COEFFICIENT OF BOTH THE GROUPS WAS ALSO TESTED WITH THE USE OF Z TRANSFORMATION AND THE DIFFERENCE WAS SIGNIFICANT (Z SYSTOLIC= 4.041 AND Z DIASTOLIC= 2.901). VALSALVA RATIO WAS ALSO FOUND TO BE SIGNIFICANTLY HIGHER IN YOGA PRACTITIONERS THAN IN CONTROLS (P<0.001). OUR RESULTS INDICATE THAT YOGA REDUCES THE AGE RELATED DETERIORATION IN CARDIOVASCULAR FUNCTIONS. 2003 18 739 32 EFFECT OF RAJA YOGA MEDITATION ON THE LIPID PROFILE OF POST-MENOPAUSAL WOMEN. BACKGROUND: CORONARY ARTERY DISEASE IS AN IMPORTANT CAUSE OF DEATH AND DISABILITY AMONG OLDER WOMEN. MODIFICATION IN LIPID PROFILE LOWERS THE RISK OF CORONARY ARTERY DISEASE. IT IS CLAIMED THAT YOGA AND TRANSCENDENTAL MEDITATION HAVE A CHOLESTEROL LOWERING EFFECT. THIS STUDY WAS DESIGNED TO ASSESS THE EFFECT OF RAJA YOGA MEDITATION OF BRAHMAKUMARIS WHICH IS VERY SIMPLE TO PRACTICE, ON SERUM LIPIDS IN NORMAL INDIAN WOMEN. METHODS AND RESULTS: 49 NORMAL FEMALE VOLUNTEERS WERE THE SUBJECTS. THEY WERE DIVIDED INTO PRE-MENOPAUSAL (N=23) AND POST-MENOPAUSAL (N=26) GROUPS. THEY WERE FURTHER DIVIDED INTO NON-MEDITATORS (WHO HAD NEVER DONE ANY KIND OF MEDITATION), SHORT-TERM MEDITATORS (MEDITATING FOR 6 MONTHS TO 5 YEARS) AND LONG-TERM MEDITATORS (MEDITATING FOR MORE THAN 5 YEARS). LIPID PROFILE WAS ASSESSED USING THEIR RESPECTIVE REAGENT SETS. SERUM CHOLESTEROL, TRIGLYCERIDE AND LOW-DENSITY LIPOPROTEIN-CHOLESTEROL IN NONMEDITATORS WERE SIGNIFICANTLY MORE IN POST-MENOPAUSAL WOMEN AS COMPARED TO PRE-MENOPAUSAL WOMEN. SERUM CHOLESTEROL AND LOW DENSITY LIPOPROTEIN-CHOLESTEROL WERE SIGNIFICANTLY LOWERED IN BOTH SHORT AND LONG TERM MEDITATORS AS COMPARED TO NON-MEDITATORS IN POST-MENOPAUSAL WOMEN. NO SIGNIFICANT DIFFERENCE WAS OBSERVED IN LIPID PROFILE IN PRE-MENOPAUSAL WOMEN. CONCLUSION: RAJA YOGA MEDITATION LOWERED SERUM CHOLESTEROL AND LOW-DENSITY LIPOPROTEIN-CHOLESTEROL IN POST-MENOPAUSAL WOMEN THUS REDUCING THE RISK OF CORONARY ARTERY DISEASE IN THEM. 2008 19 692 36 EFFECT OF COMMUNITY-BASED YOGA INTERVENTION ON OXIDATIVE STRESS AND GLYCEMIC PARAMETERS IN PREDIABETES: A RANDOMIZED CONTROLLED TRIAL. OBJECTIVES: TO STUDY THE EFFECTIVENESS OF YOGA INTERVENTION ON OXIDATIVE STRESS, GLYCEMIC STATUS, BLOOD PRESSURE AND ANTHROPOMETRY IN PREDIABETES. DESIGN: RANDOMIZED-CONTROLLED TRIAL. PARTICIPANTS: TWENTY NINE PREDIABETES SUBJECTS AGED 30-75 YEARS. SETTING: YOGA WAS CONDUCTED AT 4 DIFFERENT COMMUNITY DIABETES CLINICS IN MANGALORE, INDIA. INTERVENTIONS: PARTICIPANTS WERE RANDOMIZED TO EITHER 3-MONTH YOGA OR WAIT-LIST CONTROL GROUPS. MAIN OUTCOME MEASURES: MALONDIALDEHYDE, GLUTATHIONE, VITAMIN C, VITAMIN E, SUPEROXIDE DISMUTASE, PLASMA GLUCOSE, GLYCATED HAEMOGLOBIN, BMI, WAIST CIRCUMFERENCE, WAIST-TO-HIP RATIO AND BLOOD PRESSURE. RESULTS: YOGA INTERVENTION RESULTED IN A SIGNIFICANT DECLINE IN MALONDIALDEHYDE (P<0.001), RELATIVE TO THE CONTROL GROUP. IN COMPARISON WITH THE CONTROL, THERE WAS A SIGNIFICANT IMPROVEMENT IN BMI, WAIST CIRCUMFERENCE, SYSTOLIC BLOOD PRESSURE AND FASTING GLUCOSE LEVELS AT FOLLOW-UP. NO SIGNIFICANT IMPROVEMENT IN GLYCATED HAEMOGLOBIN, WAIST-TO-HIP RATIO OR ANY OF THE ANTIOXIDANTS WAS OBSERVED. CONCLUSIONS: YOGA INTERVENTION MAY BE HELPFUL IN CONTROL OF OXIDATIVE STRESS IN PREDIABETES SUBJECTS. YOGA CAN ALSO BE BENEFICIAL IN REDUCTION IN BMI, WAIST CIRCUMFERENCE, SYSTOLIC BLOOD PRESSURE AND FASTING GLUCOSE. EFFECT OF YOGA ON ANTIOXIDANT PARAMETERS WAS NOT EVIDENT IN THIS STUDY. THE FINDINGS OF THIS STUDY NEED TO BE CONFIRMED IN LARGER TRIALS INVOLVING ACTIVE CONTROL GROUPS. 2013 20 895 31 EFFECT OF YOGA-NIDRA ON BLOOD GLUCOSE LEVEL IN DIABETIC PATIENTS. DIABETES IS A METABOLIC DISORDER, WHICH HAS BECOME A MAJOR HEALTH CHALLENGE WORLDWIDE. SOUTH EAST ASIAN COUNTRIES HAVE A HIGHEST BURDEN OF DIABETES. IN INDIA THE PREVALENCE OF DIABETES IS RISING RAPIDLY ESPECIALLY IN THE URBAN POPULATION BECAUSE OF INCREASING OBESITY AND REDUCED PHYSICAL ACTIVITY. AN OBJECTIVE OF THIS STUDY IS TO EVALUATE THE EFFECT OF YOGA-NIDRA ON BLOOD GLUCOSE LEVEL IN DIABETIC PATIENTS. THIS STUDY WAS CONDUCTED ON 41, MIDDLE AGED, TYPE-2 DIABETIC PATIENTS, WHO WERE ON ORAL HYPOGLYCAEMIC. THESE PATIENTS WERE DIVIDED IN TO TWO GROUPS: (A) 20 PATIENTS ON ORAL HYPOGLYCAEMIC WITH YOGA-NIDRA, AND (B) 21 WERE ON ORAL HYPOGLYCAEMIC ALONE. YOGA-NIDRA PRACTICED FOR 30 MINUTES DAILY UP TO 90 DAYS, PARAMETERS WERE RECORDED EVERY. 30TH DAY. RESULTS OF THIS STUDY SHOWED THAT MOST OF THE SYMPTOMS WERE SUBSIDED (P < 0.004, SIGNIFICANT), AND FALL OF MEAN BLOOD GLUCOSE LEVEL WAS SIGNIFICANT AFTER 3-MONTH OF YOGA-NIDRA. THIS FALL WAS 21.3 MG/DL, P < 0.0007, (FROM 159 +/- 12.27 TO 137.7 +/- 23.15,) IN FASTING AND 17.95 MG/DL, P = 0.02, (FROM 255.45 +/- 16.85 TO 237.5 +/- 30.54) IN POST PRANDIAL GLUCOSE LEVEL. RESULTS OF THIS STUDY SUGGEST THAT SUBJECTS ON YOGA-NIDRA WITH DRUG REGIMEN HAD BETTER CONTROL IN THEIR FLUCTUATING BLOOD GLUCOSE AND SYMPTOMS ASSOCIATED WITH DIABETES, COMPARED TO THOSE WERE ON ORAL HYPOGLYCAEMICS ALONE. 2009