1 2334 131 TWELVE-WEEK YOGA VS. AEROBIC CYCLING INITIATION IN SEDENTARY HEALTHY SUBJECTS: A BEHAVIORAL AND MULTIPARAMETRIC INTERVENTIONAL PET/MR STUDY. INTERVENTIONAL YOGA STUDIES WITH AN ACTIVE CONTROL GROUP REMAIN SCARCE AND ARE IMPORTANT TO CLARIFY THE UNDERLYING NEUROBIOLOGY. WE CONDUCTED AN INTERVENTIONAL STUDY IN HEALTHY CONTROLS USING SIMULTANEOUS POSITRON EMISSION TOMOGRAPHY/MAGNETIC RESONANCE (PET/MR) IMAGING AND PSYCHOMETRIC SCALES. THIRTY HEALTHY, FEMALE VOLUNTEERS (28.4 +/- 8.4 YEARS) PARTICIPATED AND WERE RANDOMLY ASSIGNED TO A 12-WEEK YOGA OR INDOOR CYCLING INTERVENTION. BEFORE AND AFTER THE INTERVENTION, [(18)F]FDG AND [(11)C]UCB-J PET WAS PERFORMED ON A SIMULTANEOUS GE SIGNA PET/MR WITH VOLUMETRIC IMAGING. PSYCHOMETRIC SCALES WERE EVALUATED ON AFFECT, MINDFULNESS, STRESS, WORRYING, SELF-COMPASSION, AND INTEROCEPTIVE AWARENESS. YOGA SUBJECTS SCORED HIGHER ON INTEROCEPTIVE AWARENESS COMPARED TO BASELINE (P < 0.001). COGNITIVE (P = 0.009) AND OVERALL COGNITIVE FUNCTIONING (P = 0.01) IMPROVED AFTER THE YOGA INTERVENTION COMPARED TO THE CYCLING GROUP. WE DID NOT OBSERVE SIGNIFICANT DIFFERENCES IN GLUCOSE METABOLISM, SYNAPTIC DENSITY, OR GRAY MATTER (GM) VOLUME. THE INDOOR CYCLING GROUP DID NOT SHOW CHANGES IN PSYCHOMETRIC VARIABLES, BUT SIGNIFICANT INCREASES IN RELATIVE GLUCOSE METABOLISM WERE OBSERVED IN THE PARAHIPPOCAMPAL/FUSIFORM GYRUS AND CEREBELLUM (P < 0.001). IN CONCLUSION, 12 WEEKS OF YOGA PRACTICE HAS SIGNIFICANT EFFECTS ON INTEROCEPTIVE AWARENESS AND PERCEIVED COGNITIVE FUNCTION IN STARTERS. LONGER INTERVENTIONS AND/OR HIGHER FREQUENCY OF YOGA PRACTICE MAY BE NEEDED TO DETECT CEREBRAL METABOLIC AND/OR MORPHOLOGIC EFFECTS ON THE MACROSCOPIC LEVEL.	2021	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
2 1555  47 LONG-TERM ASHTANGA YOGA PRACTICE DECREASES MEDIAL TEMPORAL AND BRAINSTEM GLUCOSE METABOLISM IN RELATION TO YEARS OF EXPERIENCE. BACKGROUND: YOGA IS INCREASINGLY POPULAR WORLDWIDE WITH SEVERAL PHYSICAL AND MENTAL BENEFITS, BUT THE UNDERLYING NEUROBIOLOGY REMAINS UNCLEAR. WHEREAS MANY STUDIES HAVE FOCUSED ON PURE MEDITATIONAL ASPECTS, THE TRIAD OF YOGA INCLUDES MEDITATION, POSTURES, AND BREATHING. WE CONDUCTED A CROSS-SECTIONAL STUDY COMPARING EXPERIENCED YOGA PRACTITIONERS TO YOGA-NAIVE HEALTHY SUBJECTS USING A MULTIPARAMETRIC 2 X 2 DESIGN WITH SIMULTANEOUS POSITRON EMISSION TOMOGRAPHY/MAGNETIC RESONANCE (PET/MR) IMAGING. METHODS: (18)F-FDG PET, MORPHOMETRIC AND DIFFUSION TENSOR IMAGING, RESTING STATE FMRI, AND MR SPECTROSCOPY WERE ACQUIRED IN 10 EXPERIENCED (4.8 +/- 2.3 YEARS OF REGULAR YOGA EXPERIENCE) YOGA PRACTITIONERS AND 15 MATCHED CONTROLS IN REST AND AFTER A SINGLE PRACTICE (YOGA PRACTICE AND PHYSICAL EXERCISE, RESPECTIVELY). RESULTS: IN REST, DECREASED REGIONAL GLUCOSE METABOLISM IN THE MEDIAL TEMPORAL CORTEX, STRIATUM, AND BRAINSTEM WAS OBSERVED IN YOGA PRACTITIONERS COMPARED TO CONTROLS (P < 0.0001), WITH A SIGNIFICANT INVERSE CORRELATION OF RESTING PARAHIPPOCAMPAL AND BRAINSTEM METABOLISM WITH YEARS OF REGULAR YOGA PRACTICE (RHO < - 0.63, P < 0.05). A SINGLE YOGA PRACTICE RESULTED IN SIGNIFICANT HYPERMETABOLISM IN THE CEREBELLUM (P < 0.0001). NONE OF THE MR MEASURES DIFFERED, BOTH AT REST AND AFTER INTERVENTION. CONCLUSIONS: EXPERIENCED YOGA PRACTITIONERS SHOW REGIONAL LONG-TERM DECREASES IN GLUCOSE METABOLISM RELATED TO YEARS OF PRACTICE. TO ELUCIDATE A POTENTIAL CAUSALITY, A PROSPECTIVE LONGITUDINAL STUDY IN YOGA-NAIVE INDIVIDUALS IS WARRANTED.	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
3 2371  32 WHAT HAS NEUROIMAGING TAUGHT US ON THE NEUROBIOLOGY OF YOGA? A REVIEW. YOGA IS BECOMING INCREASINGLY POPULAR WORLDWIDE, WITH SEVERAL IMPLICATED PHYSICAL AND MENTAL BENEFITS. HERE WE PROVIDE A COMPREHENSIVE AND CRITICAL REVIEW OF THE RESEARCH GENERATED FROM THE EXISTING NEUROIMAGING LITERATURE IN STUDIES OF YOGA PRACTITIONERS. WE REVIEWED 34 INTERNATIONAL PEER-REVIEWED NEUROIMAGING STUDIES OF YOGA USING MAGNETIC RESONANCE IMAGING (MRI), POSITRON EMISSION TOMOGRAPHY (PET), OR SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY (SPECT): 11 MORPHOLOGICAL AND 26 FUNCTIONAL STUDIES, INCLUDING THREE STUDIES THAT WERE CLASSIFIED AS BOTH MORPHOLOGICAL AND FUNCTIONAL. CONSISTENT FINDINGS INCLUDE INCREASED GRAY MATTER VOLUME IN THE INSULA AND HIPPOCAMPUS, INCREASED ACTIVATION OF PREFRONTAL CORTICAL REGIONS, AND FUNCTIONAL CONNECTIVITY CHANGES MAINLY WITHIN THE DEFAULT MODE NETWORK. THERE IS QUITE SOME VARIABILITY IN THE NEUROIMAGING FINDINGS THAT PARTIALLY REFLECTS DIFFERENT YOGA STYLES AND APPROACHES, AS WELL AS SAMPLE SIZE LIMITATIONS. DIRECT COMPARATOR GROUPS SUCH AS PHYSICAL ACTIVITY ARE SCARCELY USED SO FAR. FINALLY, HYPOTHESES ON THE UNDERLYING NEUROBIOLOGY DERIVED FROM THE IMAGING FINDINGS ARE DISCUSSED IN THE LIGHT OF THE POTENTIAL BENEFICIAL EFFECTS OF YOGA.	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
4  447  28 CHANGED PATTERN OF REGIONAL GLUCOSE METABOLISM DURING YOGA MEDITATIVE RELAXATION. USING POSITRON EMISSION TOMOGRAPHY (PET), MEASUREMENTS OF THE REGIONAL CEREBRAL METABOLIC RATE OF GLUCOSE (RCMRGLC) ARE ABLE TO DELINEATE CEREBRAL METABOLIC RESPONSES TO EXTERNAL OR MENTAL STIMULATION. IN ORDER TO EXAMINE POSSIBLE CHANGES OF BRAIN METABOLISM DUE TO YOGA MEDITATION PET SCANS WERE PERFORMED IN 8 MEMBERS OF A YOGA MEDITATION GROUP DURING THE NORMAL CONTROL STATE (C) AND YOGA MEDITATIVE RELAXATION (YMR). WHEREAS THERE WERE INTRAINDIVIDUAL CHANGES OF THE TOTAL CMRGLC, THE ALTERATIONS WERE NOT SIGNIFICANT FOR INTERGROUP COMPARISON; SPECIFIC FOCAL CHANGES OR CHANGES IN THE INTERHEMISPHERIC DIFFERENCES IN METABOLISM WERE ALSO NOT SEEN; HOWEVER THE RATIOS OF FRONTAL VS. OCCIPITAL RCMRGLC WERE SIGNIFICANTLY ELEVATED (P LESS THAN 0.05) DURING YMR. THESE ALTERED RATIOS WERE CAUSED BY A SLIGHT INCREASE OF FRONTAL RCMRGLC AND A MORE PRONOUNCED REDUCTION IN PRIMARY AND SECONDARY VISUAL CENTERS. THESE DATA INDICATE A HOLISTIC BEHAVIOR OF THE BRAIN METABOLISM DURING THE TIME OF ALTERED STATE OF CONSCIOUSNESS DURING YMR.	1990	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
5  441  33 CEREBRAL BLOOD FLOW EFFECTS OF YOGA TRAINING: PRELIMINARY EVALUATION OF 4 CASES. OBJECTIVES: EXPERIENCED PRACTITIONERS OF YOGA HAVE BEEN SHOWN TO ALTER BRAIN FUNCTION, BUT THIS CASE SERIES MEASURED CEREBRAL BLOOD FLOW BEFORE AND AFTER A 12-WEEK TRAINING PROGRAM IN IYENGAR YOGA (IY) FOR NAIVE SUBJECTS. METHODS: ON THE FIRST DAY, EACH OF THE 4 SUBJECTS LISTENED TO THE TEACHER SPEAKING ON THE HISTORY AND BACKGROUND OF THE YOGA PROGRAM WHILE THEY WERE INJECTED WITH 250 MBQ OF (99M)TC-BICISATE AND RECEIVED A SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY SCAN (PRE-PROGRAM BASELINE). SUBJECTS THEN HAD THEIR FIRST IY TRAINING AND WERE INJECTED AND SCANNED WITH 925 MBQ BICISATE WHILE THEY DID THEIR FIRST MEDITATION (PRE-PROGRAM MEDITATION). SUBJECTS THEN UNDERWENT A 12-WEEK TRAINING PROGRAM IN IY AND THEN UNDERWENT THE SAME IMAGING PROTOCOL WITH A POSTPROGRAM BASELINE AND POSTPROGRAM MEDITATION SCAN. BASELINE AND MEDITATION SCANS, BEFORE AND AFTER TRAINING, WERE COMPARED USING PAIRED T TESTS. RESULTS: THERE WERE SIGNIFICANT DECREASES (P < 0.05) BETWEEN THE PRE- AND POSTPROGRAM BASELINE SCANS IN THE RIGHT AMYGDALA, DORSAL MEDIAL CORTEX, AND SENSORIMOTOR AREA. THERE WAS A SIGNIFICANT DIFFERENCE (P < 0.05) IN THE PRE- AND POSTPROGRAM PERCENTAGE CHANGE (I.E., ACTIVATION) IN THE RIGHT DORSAL MEDIAL FRONTAL LOBE, PREFRONTAL CORTEX, AND RIGHT SENSORIMOTOR CORTEX. CONCLUSIONS: THESE INITIAL FINDINGS SUGGEST THE BRAIN EXPERIENCES A "TRAINING EFFECT" AFTER 12 WEEKS OF IY TRAINING.	2009	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
6 1439  28 INCREASED GREY MATTER ASSOCIATED WITH LONG-TERM SAHAJA YOGA MEDITATION: A VOXEL-BASED MORPHOMETRY STUDY. OBJECTIVES: TO INVESTIGATE REGIONAL DIFFERENCES IN GREY MATTER VOLUME ASSOCIATED WITH THE PRACTICE OF SAHAJA YOGA MEDITATION. DESIGN: TWENTY THREE EXPERIENCED PRACTITIONERS OF SAHAJA YOGA MEDITATION AND TWENTY THREE NON-MEDITATORS MATCHED ON AGE, GENDER AND EDUCATION LEVEL, WERE SCANNED USING STRUCTURAL MAGNETIC RESONANCE IMAGING AND THEIR GREY MATTER VOLUME WERE COMPARED USING VOXEL-BASED MORPHOMETRY. RESULTS: GREY MATTER VOLUME WAS LARGER IN MEDITATORS RELATIVE TO NON-MEDITATORS ACROSS THE WHOLE BRAIN. IN ADDITION, GREY MATTER VOLUME WAS LARGER IN SEVERAL PREDOMINANTLY RIGHT HEMISPHERIC REGIONS: IN INSULA, VENTROMEDIAL ORBITOFRONTAL CORTEX, INFERIOR TEMPORAL AND PARIETAL CORTICES AS WELL AS IN LEFT VENTROLATERAL PREFRONTAL CORTEX AND LEFT INSULA. NO AREAS WITH LARGER GREY MATTER VOLUME WERE FOUND IN NON-MEDITATORS RELATIVE TO MEDITATORS. CONCLUSIONS: THE STUDY SHOWS THAT LONG-TERM PRACTICE OF SAHAJA YOGA MEDITATION IS ASSOCIATED WITH LARGER GREY MATTER VOLUME OVERALL, AND WITH REGIONAL ENLARGEMENT IN SEVERAL RIGHT HEMISPHERIC CORTICAL AND SUBCORTICAL BRAIN REGIONS THAT ARE ASSOCIATED WITH SUSTAINED ATTENTION, SELF-CONTROL, COMPASSION AND INTEROCEPTIVE PERCEPTION. THE INCREASED GREY MATTER VOLUME IN THESE ATTENTION AND SELF-CONTROL MEDIATING REGIONS SUGGESTS USE-DEPENDENT ENLARGEMENT WITH REGULAR PRACTICE OF THIS MEDITATION.	2016	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
7  968  46 EFFECTS OF AN 8-MONTH ASHTANGA-BASED YOGA INTERVENTION ON BONE METABOLISM IN MIDDLE-AGED PREMENOPAUSAL WOMEN: A RANDOMIZED CONTROLLED STUDY. ALTHOUGH YOGA HAS THE POTENTIAL TO BE AN ALTERNATIVE PHYSICAL ACTIVITY TO ENHANCE BONE HEALTH, THERE IS A LACK OF HIGH QUALITY EVIDENCE FOR THIS TYPE OF INTERVENTION. THE PURPOSE OF THIS RANDOMIZED CONTROLLED TRIAL WAS TO EXAMINE THE EFFECTS OF A PROGRESSIVE 8-MONTH ASHTANGA-BASED YOGA PROGRAM ON BONE TURNOVER MARKERS (BTM), AREAL BONE MINERAL DENSITY (ABMD) AND VOLUMETRIC BONE CHARACTERISTICS IN PREMENOPAUSAL WOMEN. THIRTY-FOUR PREMENOPAUSAL WOMEN (35-50 YEARS) WERE RANDOMLY ASSIGNED EITHER TO A YOGA GROUP (YE, N = 16) OR A CONTROL GROUP (CON, N = 18). PARTICIPANTS IN YE GROUP PERFORMED 60 MINUTES OF AN ASHTANGA-BASED YOGA SERIES 2 TIMES/WEEK WITH ONE DAY BETWEEN SESSIONS FOR 8 MONTHS, AND THE SESSION INTENSITY WAS PROGRESSIVELY INCREASED BY ADDING THE NUMBER OF SUN SALUTATIONS (SS). PARTICIPANTS IN CON WERE ENCOURAGED TO MAINTAIN THEIR NORMAL DAILY LIFESTYLES MONITORED BY THE BONE SPECIFIC PHYSICAL ACTIVITY QUESTIONNAIRE (BPAQ) AT 2 MONTH INTERVALS FOR 8 MONTHS. BODY COMPOSITION WAS MEASURED BY DUAL ENERGY X-RAY ABSORPTIOMETRY (DXA). BONE FORMATION (BONE ALKALINE PHOSPHATASE, BONE ALP) AND BONE RESORPTION (TARTRATE-RESISTANT ACID PHOSPHATASE-5B, TRAP5B) MARKERS WERE ASSESSED AT BASELINE AND AFTER 8 MONTHS. ABMD OF TOTAL BODY, LUMBAR SPINE AND DUAL PROXIMAL FEMUR AND TIBIA BONE CHARACTERISTICS WERE MEASURED USING DXA AND PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY (PQCT), RESPECTIVELY. WE FOUND THAT THE SERUM BONE ALP CONCENTRATIONS WERE MAINTAINED IN YE, BUT SIGNIFICANTLY (P = 0.005) DECREASED IN CON AFTER THE 8 MONTH INTERVENTION, AND THERE WERE SIGNIFICANT (P = 0.002) GROUP DIFFERENCES IN BONE ALP PERCENT CHANGES (YE 9.1 +/- 4.0% VS. CON -7.1 +/- 2.3%). NO CHANGES IN TRAP5B WERE FOUND IN EITHER GROUP. THE 8-MONTH YOGA PROGRAM DID NOT INCREASE ABMD OR TIBIA BONE STRENGTH VARIABLES. BODY COMPOSITION RESULTS SHOWED NO CHANGES IN WEIGHT, FAT MASS, OR % FAT, BUT SMALL SIGNIFICANT INCREASES IN BONE FREE LEAN BODY MASS OCCURRED IN BOTH GROUPS. THE FINDINGS OF THIS STUDY SUGGEST THAT REGULAR LONG-TERM ASHTANGA YOGA HAD A SMALL POSITIVE EFFECT ON BONE FORMATION BUT DID NOT ALTER ABMD OR TIBIA BONE CHARACTERISTICS IN PREMENOPAUSAL WOMEN. KEY POINTSREGULAR LONG-TERM ASHTANGA-BASED YOGA PROGRAM HAD A SMALL POSITIVE EFFECT ON BONE FORMATION, BUT NO EFFECTS WERE FOUND ON BONE RESORPTION.NONE OF THE BONE DENSITY OR GEOMETRY VARIABLES WERE CHANGED BY THE 8-MONTH ASHTANGA-BASED YOGA INTERVENTION.FUTURE YOGA INTERVENTIONS SHOULD FOCUS ON LONGER DURATION AND GREATER FREQUENCY TO ELICIT IMPROVEMENTS IN BONE MINERAL DENSITY.	2015	

8 1545  31 LARGER WHOLE BRAIN GREY MATTER ASSOCIATED WITH LONG-TERM SAHAJA YOGA MEDITATION: A DETAILED AREA BY AREA COMPARISON. OBJECTIVES: OUR PREVIOUS STUDY SHOWED THAT LONG-TERM PRACTITIONERS OF SAHAJA YOGA MEDITATION (SYM) HAD AROUND 7% LARGER GREY MATTER VOLUME (GMV) IN THE WHOLE BRAIN COMPARED WITH HEALTHY CONTROLS; HOWEVER, WHEN TESTING INDIVIDUAL REGIONS, ONLY 5 SMALL BRAIN AREAS WERE STATISTICALLY DIFFERENT BETWEEN GROUPS. UNDER THE HYPOTHESIS THAT THOSE RESULTS WERE STATISTICALLY CONSERVATIVE, WITH THE SAME DATASET, WE INVESTIGATED IN MORE DETAIL THE REGIONAL DIFFERENCES IN GMV ASSOCIATED WITH THE PRACTICE OF SYM, WITH A DIFFERENT STATISTICAL APPROACH. DESIGN: TWENTY-THREE EXPERIENCED PRACTITIONERS OF SYM AND 23 HEALTHY NON-MEDITATORS MATCHED ON AGE, SEX AND EDUCATION LEVEL, WERE SCANNED USING STRUCTURAL MAGNETIC RESONANCE IMAGING (MRI). THEIR GMV WERE EXTRACTED AND COMPARED USING VOXEL-BASED MORPHOMETRY (VBM). USING A NOVEL AD-HOC GENERAL LINEAR MODEL, STATISTICAL COMPARISONS WERE MADE TO OBSERVE IF THE GMV DIFFERENCES BETWEEN MEDITATORS AND CONTROLS WERE STATISTICALLY SIGNIFICANT. RESULTS: IN THE 16 LOBE AREA SUBDIVISIONS, GMV WAS STATISTICALLY SIGNIFICANTLY DIFFERENT IN 4 OUT OF 16 AREAS: IN RIGHT HEMISPHERIC TEMPORAL AND FRONTAL LOBES, LEFT FRONTAL LOBE AND BRAINSTEM. IN THE 116 AAL AREA SUBDIVISIONS, GMV DIFFERENCE WAS STATISTICALLY SIGNIFICANT IN 11 AREAS. THE GMV DIFFERENCES WERE STATISTICALLY MORE SIGNIFICANT IN RIGHT HEMISPHERIC BRAIN AREAS. CONCLUSIONS: THE STUDY SHOWS THAT LONG-TERM PRACTICE OF SYM IS ASSOCIATED WITH LARGER GMV OVERALL, AND WITH SIGNIFICANT DIFFERENCES MAINLY IN TEMPORAL AND FRONTAL AREAS OF THE RIGHT HEMISPHERE AND THE BRAINSTEM. THESE NEUROPLASTIC CHANGES MAY REFLECT EMOTIONAL AND ATTENTIONAL CONTROL MECHANISMS DEVELOPED WITH SYM. ON THE OTHER HAND, OUR STATISTICAL AD-HOC METHOD SHOWS THAT THERE WERE MORE BRAIN AREAS WITH STATISTICAL SIGNIFICANCE COMPARED TO THE TRADITIONAL METHODOLOGY WHICH WE THINK IS SUSCEPTIBLE TO CONSERVATIVE TYPE II ERRORS.	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
9 1670  27 NEUROPROTECTIVE EFFECTS OF YOGA PRACTICE: AGE-, EXPERIENCE-, AND FREQUENCY-DEPENDENT PLASTICITY. YOGA COMBINES POSTURES, BREATHING, AND MEDITATION. DESPITE REPORTED HEALTH BENEFITS, YOGA'S EFFECTS ON THE BRAIN HAVE RECEIVED LITTLE STUDY. WE USED MAGNETIC RESONANCE IMAGING TO COMPARE AGE-RELATED GRAY MATTER (GM) DECLINE IN YOGIS AND CONTROLS. WE ALSO EXAMINED THE EFFECT OF INCREASING YOGA EXPERIENCE AND WEEKLY PRACTICE ON GM VOLUME AND ASSESSED WHICH ASPECTS OF WEEKLY PRACTICE CONTRIBUTED MOST TO BRAIN SIZE. CONTROLS DISPLAYED THE WELL DOCUMENTED AGE-RELATED GLOBAL BRAIN GM DECLINE WHILE YOGIS DID NOT, SUGGESTING THAT YOGA CONTRIBUTES TO PROTECT THE BRAIN AGAINST AGE-RELATED DECLINE. YEARS OF YOGA EXPERIENCE CORRELATED MOSTLY WITH GM VOLUME DIFFERENCES IN THE LEFT HEMISPHERE (INSULA, FRONTAL OPERCULUM, AND ORBITOFRONTAL CORTEX) SUGGESTING THAT YOGA TUNES THE BRAIN TOWARD A PARASYMPATICALLY DRIVEN MODE AND POSITIVE STATES. THE NUMBER OF HOURS OF WEEKLY PRACTICE CORRELATED WITH GM VOLUME IN THE PRIMARY SOMATOSENSORY CORTEX/SUPERIOR PARIETAL LOBULE (S1/SPL), PRECUNEUS/POSTERIOR CINGULATE CORTEX (PCC), HIPPOCAMPUS, AND PRIMARY VISUAL CORTEX (V1). COMMONALITY ANALYSES INDICATED THAT THE COMBINATION OF POSTURES AND MEDITATION CONTRIBUTED THE MOST TO THE SIZE OF THE HIPPOCAMPUS, PRECUNEUS/PCC, AND S1/SPL WHILE THE COMBINATION OF MEDITATION AND BREATHING EXERCISES CONTRIBUTED THE MOST TO V1 VOLUME. YOGA'S POTENTIAL NEUROPROTECTIVE EFFECTS MAY PROVIDE A NEURAL BASIS FOR SOME OF ITS BENEFICIAL EFFECTS.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
10 1286  30 GRAY MATTER AND FUNCTIONAL CONNECTIVITY IN ANTERIOR CINGULATE CORTEX ARE ASSOCIATED WITH THE STATE OF MENTAL SILENCE DURING SAHAJA YOGA MEDITATION. SOME MEDITATION TECHNIQUES TEACH THE PRACTITIONER TO ACHIEVE THE STATE OF MENTAL SILENCE. THE AIM OF THIS STUDY WAS TO INVESTIGATE BRAIN REGIONS THAT ARE ASSOCIATED WITH THEIR VOLUME AND FUNCTIONAL CONNECTIVITY (FC) WITH THE DEPTH OF MENTAL SILENCE IN LONG-TERM PRACTITIONERS OF SAHAJA YOGA MEDITATION. TWENTY-THREE LONG-TERM PRACTITIONERS OF THIS MEDITATION WERE SCANNED USING MAGNETIC RESONANCE IMAGING. IN ORDER TO IDENTIFY THE NEURAL CORRELATES OF THE DEPTH OF MENTAL SILENCE, WE TESTED WHICH GRAY MATTER VOLUMES (GMV) WERE CORRELATED WITH THE DEPTH OF MENTAL SILENCE AND WHICH REGIONS THESE AREAS WERE FUNCTIONALLY CONNECTED TO UNDER A MEDITATION CONDITION. GMV IN MEDIAL PREFRONTAL CORTEX INCLUDING ROSTRAL ANTERIOR CINGULATE CORTEX WERE POSITIVELY CORRELATED WITH THE SUBJECTIVE PERCEPTION OF THE DEPTH OF MENTAL SILENCE INSIDE THE SCANNER. FURTHERMORE, THERE WAS SIGNIFICANTLY INCREASED FC BETWEEN THIS AREA AND BILATERAL ANTERIOR INSULA/PUTAMEN DURING A MEDITATION-STATE SPECIFICALLY, WHILE DECREASED CONNECTIVITY WITH THE RIGHT THALAMUS/PARAHIPPOCAMPAL GYRUS WAS PRESENT DURING THE MEDITATION-STATE AND THE RESTING-STATE. THE CAPACITY OF LONG-TERM MEDITATORS TO ESTABLISH A DURABLE STATE OF MENTAL SILENCE INSIDE AN MRI SCANNER WAS ASSOCIATED WITH LARGER GRAY MATTER VOLUME IN A MEDIAL FRONTAL REGION THAT IS CRUCIAL FOR TOP-DOWN COGNITIVE, EMOTION AND ATTENTION CONTROL. THIS IS FURTHERMORE CORROBORATED BY INCREASED FC OF THIS REGION DURING THE MEDITATION-STATE WITH BILATERAL ANTERIOR INSULA/PUTAMEN, WHICH ARE IMPORTANT FOR INTEROCEPTION, EMOTION, AND ATTENTION REGULATION. THE FINDINGS HENCE SUGGEST THAT THE DEPTH OF MENTAL SILENCE IS ASSOCIATED WITH MEDIAL FRONTO-INSULAR-STRIATAL NETWORKS THAT ARE CRUCIAL FOR TOP-DOWN ATTENTION AND EMOTIONAL CONTROL.	2018	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
11 2693  30 YOGA INCREASES THE VOLUME OF THE HIPPOCAMPUS IN ELDERLY SUBJECTS. CONTEXT: THE NEUROBIOLOGICAL EFFECT OF YOGA ON THE CORTICAL STRUCTURES IN THE ELDERLY IS AS YET UNKNOWN. MATERIALS AND METHODS: SEVEN HEALTHY ELDERLY SUBJECTS RECEIVED YOGA INTERVENTION AS AN ADD-ON LIFE-STYLE PRACTICE. MAGNETIC RESONANCE IMAGING SCANS WERE OBTAINED BEFORE AND 6 MONTHS LATER. VOXEL-BASED-MORPHOMETRIC ANALYSES COMPARED THE BRAINS BEFORE AND AFTER THE YOGA. RESULTS: YOGA GROUP WAS FOUND TO HAVE INCREASES IN HIPPOCAMPAL, BUT NOT IN OCCIPITAL GRAY MATTER. CONCLUSION: YOGA HAS POTENTIAL TO REDUCE NEURO-SENESCENCE. SMALL SAMPLE SIZE AND ABSENCE OF THE CONTROL GROUP PREVENT GENERALIZATION OF THE FINDINGS LIMITING ITS TRANSLATIONAL VALUE.	2013	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
12 1032  29 EFFECTS OF YOGA EXERCISES ON DIABETIC MELLITUS AS VALIDATED BY MAGNETIC RESONANCE IMAGING. CONTEXT AND AIMS: EFFECTS OF PRACTICING YOGA IN DIABETIC MELLITUS (DM) PATIENTS HAVE BEEN IDENTIFIED TO IMPROVE IN CONTROL OF BLOOD GLUCOSE LEVELS. THE PURPOSE OF THIS WORK IS TO EVALUATE CHANGES IN BLOOD FLOW OF CALF MUSCLES AFTER SPECIFIC YOGA POSTURES FOR PATIENTS WITH DM USING MAGNETIC RESONANCE IMAGING (MRI) TECHNIQUES. TIME OF FLIGHT (TOF) MAGNETIC RESONANCE ANGIOGRAPHY MAXIMUM INTENSITY PROJECTION (MIP), T1 MAPS, T2 MAPS, AND DIFFUSION-WEIGHTED IMAGING ARE PERFORMED ON VOLUNTEERS AND DM PATIENTS BOTH PRE- AND POST-EXERCISE. MATERIALS AND METHODS: TOF MIP, T1 MAPS WITH VARIABLE FLIP ANGLES, AND T2-WEIGHTED SPIN-ECHO IMAGING WERE PERFORMED ON FOUR VOLUNTEERS (AGED 30 +/- 5) AND DM PATIENTS (AGED 32-68) PREEXERCISE, ON A 1.5 T SIEMENS SCANNER. THE TOTAL ACQUISITION TIME WAS 6 MIN 20 S. EACH VOLUNTEER AND DM PATIENT WERE THEN REQUESTED TO PERFORM YOGA POSTURES SUPTA PADANGUSTHASANA, UTKATASANA, AND CALF RAISE FOR 6 MIN 30 S AT MAXIMUM EFFORT, OUTSIDE THE SCANNER, AND SUBSEQUENTLY RESCANNED. TO CALCULATE SIGNIFICANT SIGNAL INCREASE, REGION OF INTERESTS WAS DRAWN ON TOF MIP CORONAL IMAGES IN ARTERIES OF CALF MUSCLES. STUDENT T-TESTS WERE PERFORMED TO DETERMINE STATISTICAL SIGNIFICANCE. RESULTS: AMONG VOLUNTEERS, A SIGNIFICANT SIGNAL INCREASE IN ARTERIES OF CALF MUSCLES WAS NOTICED, SIGNAL INTENSITY GRAPHS WERE PLOTTED. IN DM PATIENTS, SIGNAL INCREASE IN TOF MIP, T2-WEIGHTED IMAGES WERE SEEN IN SPECIFIC ARTERIES (POSTERIOR, ANTERIOR TIBIAL, AND POSTERIOR TIBIAL) OF CALF MUSCLES POSTEXERCISE. DISCUSSION AND CONCLUSIONS: THE STUDY INDICATES THAT YOGA HAS A POSITIVE SHORT-TERM EFFECT ON MULTIPLE DM-RELATED FOOT COMPLICATIONS. THIS STUDY DEPICTS THAT MRI PROVIDES POTENTIAL INSIGHT INTO THE BENEFITS OF YOGA FOR DM PATIENTS THROUGH DERIVING BIOMARKERS FOR PREVENTIVE MEDICINE RELEVANT TO YOGA INTERCEPTION.	2021	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
13  573  15 DELAYED UNION OF STRESS FRACTURE OF THE FIRST RIB IN A YOGA INSTRUCTOR: A CASE REPORT. CASE: WE DESCRIBE THE CASE OF A 38-YEAR-OLD WOMAN, A YOGA INSTRUCTOR, WHO HAD PAIN IN THE RIGHT SHOULDER AND SCAPULAR REGION OF 4 MONTHS' DURATION WHILE PERFORMING YOGA. RADIOGRAPHY AND COMPUTED TOMOGRAPHY DIAGNOSED DELAYED UNION OF A FIRST RIB STRESS FRACTURE. THE DELAYED UNION OF STRESS FRACTURE OF THE FIRST RIB WAS SUCCESSFULLY TREATED WITH THE LIMITING OF YOGA ACTIVITY AND LOW-INTENSITY PULSED ULTRASOUND (LIPUS). CONCLUSIONS: PHYSICIANS SHOULD BE AWARE THAT EVEN YOGA POSING CAN CAUSE STRESS FRACTURES OF THE FIRST RIB. LIPUS THERAPY MAY BE EFFECTIVE FOR DELAYED UNION IN ADDITION TO REST.	2021	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
14 1641  22 MONITORING THE NEURAL ACTIVITY OF THE STATE OF MENTAL SILENCE WHILE PRACTICING SAHAJA YOGA MEDITATION. OBJECTIVE: TO IDENTIFY THE NEURAL CORRELATES OF THE STATE OF MENTAL SILENCE AS EXPERIENCED THROUGH SAHAJA YOGA MEDITATION. DESIGN: NINETEEN EXPERIENCED MEDITATORS UNDERWENT FUNCTIONAL MAGNETIC RESONANCE IMAGING DURING THREE SHORT CONSECUTIVE MEDITATION PERIODS, CONTRASTED WITH A CONTROL RELAXATION CONDITION. RESULTS: RELATIVE TO BASELINE, AT THE BEGINNING OF THE MEDITATION SESSIONS THERE WAS A SIGNIFICANT INCREASE OF ACTIVATION IN BILATERAL INFERIOR FRONTAL AND TEMPORAL REGIONS. ACTIVATION BECAME PROGRESSIVELY MORE REDUCED WITH DEEPER MEDITATION STAGES AND IN THE LAST MEDITATION SESSION IT BECAME LOCALIZED TO THE RIGHT INFERIOR FRONTAL CORTEX/ RIGHT INSULA AND RIGHT MIDDLE/SUPERIOR TEMPORAL CORTEX. FURTHERMORE, RIGHT INFERIOR FRONTAL ACTIVATION WAS DIRECTLY ASSOCIATED WITH THE SUBJECTIVE DEPTH OF THE MENTAL SILENCE EXPERIENCE. CONCLUSIONS: MEDITATORS APPEAR TO PASS THROUGH AN INITIAL INTENSE NEURAL SELF-CONTROL PROCESS NECESSARY TO SILENCE THEIR MIND. AFTER THIS THEY EXPERIENCE RELATIVELY REDUCED BRAIN ACTIVATION CONCOMITANT WITH THE DEEPENING OF THE STATE OF MENTAL SILENCE OVER RIGHT INFERIOR FRONTAL CORTEX, PROBABLY REFLECTING AN EFFORTLESS PROCESS OF ATTENTIONAL CONTEMPLATION ASSOCIATED WITH THIS STATE.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
15 1498  32 INTRAOCULAR PRESSURE CHANGES AND OCULAR BIOMETRY DURING SIRSASANA (HEADSTAND POSTURE) IN YOGA PRACTITIONERS. PURPOSE: TO STUDY THE INTRAOCULAR PRESSURE (IOP) CHANGES IN SIRSASANA (HEADSTAND POSTURE) DONE BY EXPERIENCED YOGA PRACTITIONERS AND CORRELATE THE OCULAR BIOMETRIC PARAMETERS WITH THE IOP CHANGES, AND TO SCREEN FOR THE PREVALENCE OF OCULAR HYPERTENSION IN THIS GROUP OF SUBJECTS. DESIGN: PROSPECTIVE CASE OBSERVATIONAL SERIES. PARTICIPANTS: SEVENTY-FIVE SUBJECTS (50 ASIAN INDIANS AND 25 CAUCASIANS) FROM A YOGA TRAINING INSTITUTE VOLUNTEERED FOR THE STUDY. METHODS: ALL PARTICIPANTS UNDERWENT A DETAILED OPHTHALMIC EXAMINATION ALONG WITH OCULAR BIOMETRY AND CORNEAL PACHYMETRY. INTRAOCULAR PRESSURE WAS RECORDED USING A TONOPEN BEFORE, DURING, AND AFTER THE SIRSASANA. CHANGES WERE COMPARED USING THE PAIRED T TEST. AGE, AXIAL LENGTH, ANTERIOR CHAMBER DEPTH, LENS THICKNESS, CORNEAL CURVATURE, CORNEAL THICKNESS, RACE, AND THE LENGTH OF TIME FOR WHICH THE PRACTITIONER WAS PERFORMING YOGA WERE CORRELATED WITH THE INDUCED IOP DIFFERENCE IN A RANDOMLY SELECTED EYE USING PEARSON'S CORRELATION COEFFICIENT WITH BONFERRONI CORRECTION FOR MULTIPLE COMPARISONS. MAIN OUTCOME MEASURES: OCULAR BIOMETRY AND INDUCED IOP DIFFERENCE. RESULTS: THE MEAN INCREASE IN IOP AT BASELINE AND IMMEDIATELY AFTER ASSUMING SIRSASANA WAS 15.1+/-4.1 MMHG (R = 0.07; P = 0.999) AND AFTER 5 MINUTES WAS 15.8+/-4.6 MMHG (R = -0.25; P = 0.357). THE INDUCED INCREASE IN IOP DURING THE POSTURE WAS TWICE THE BASELINE IOP. THERE WAS NO CORRELATION BETWEEN AGE, OCULAR BIOMETRY, AND ULTRASOUND PACHYMETRY WHEN COMPARED WITH THE INDUCED IOP DIFFERENCE. ONE SUBJECT (1.33%) WAS FOUND TO HAVE BASELINE IOP OF MORE THAN 21 MMHG. CONCLUSION: THERE WAS A UNIFORM 2-FOLD INCREASE IN THE IOP DURING SIRSASANA, WHICH WAS MAINTAINED DURING THE POSTURE IN ALL AGE GROUPS IRRESPECTIVE OF THE OCULAR BIOMETRY AND ULTRASOUND PACHYMETRY. WE DID NOT DEMONSTRATE A HIGHER PREVALENCE OF OCULAR HYPERTENSIVES IN THIS COHORT OF YOGA PRACTITIONERS NOR DID THE RISK FACTORS CONTRIBUTING TO GLAUCOMA SHOW ANY CORRELATION WITH MAGNITUDE OF IOP RAISE DURING THE POSTURE.	2006	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
16 1496  28 INTRACEREBRAL PAIN PROCESSING IN A YOGA MASTER WHO CLAIMS NOT TO FEEL PAIN DURING MEDITATION. WE RECORDED MAGNETOENCEPHALOGRAPHY (MEG) AND FUNCTIONAL MAGNETIC RESONANCE IMAGING (FMRI) FOLLOWING NOXIOUS LASER STIMULATION IN A YOGA MASTER WHO CLAIMS NOT TO FEEL PAIN WHEN MEDITATING. AS FOR BACKGROUND MEG ACTIVITY, THE POWER OF ALPHA FREQUENCY BANDS PEAKING AT AROUND 10 HZ WAS MUCH INCREASED DURING MEDITATION OVER OCCIPITAL, PARIETAL AND TEMPORAL REGIONS, WHEN COMPARED WITH THE NON-MEDITATIVE STATE, WHICH MIGHT MEAN THE SUBJECT WAS VERY RELAXED, THOUGH HE DID NOT FALL ASLEEP, DURING MEDITATION. PRIMARY PAIN-RELATED CORTICAL ACTIVITIES RECORDED FROM PRIMARY (SI) AND SECONDARY SOMATOSENSORY CORTICES (SII) BY MEG WERE VERY WEAK OR ABSENT DURING MEDITATION. AS FOR FMRI RECORDING, THERE WERE REMARKABLE CHANGES IN LEVELS OF ACTIVITY IN THE THALAMUS, SII-INSULA (MAINLY THE INSULA) AND CINGULATE CORTEX BETWEEN MEDITATION AND NON-MEDITATION. ACTIVITIES IN ALL THREE REGIONS WERE INCREASED DURING NON-MEDITATION, SIMILAR TO RESULTS IN NORMAL SUBJECTS. IN CONTRAST, ACTIVITIES IN ALL THREE REGIONS WERE WEAKER DURING MEDITATION, AND THE LEVEL WAS LOWER THAN THE BASELINE IN THE THALAMUS. RECENT NEUROIMAGING AND ELECTROPHYSIOLOGICAL STUDIES HAVE CLARIFIED THAT THE EMOTIONAL ASPECT OF PAIN PERCEPTION MAINLY INVOLVES THE INSULA AND CINGULATE CORTEX. THOUGH WE CANNOT CLEARLY EXPLAIN THIS UNUSUAL CONDITION IN THE YOGA MASTER, A CHANGE OF MULTIPLE REGIONS RELATING TO PAIN PERCEPTION COULD BE RESPONSIBLE, SINCE PAIN IS A COMPLEX SENSORY AND EMOTIONAL EXPERIENCE.	2005	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
17 1472  28 INSULAR CORTEX MEDIATES INCREASED PAIN TOLERANCE IN YOGA PRACTITIONERS. YOGA, AN INCREASINGLY POPULAR DISCIPLINE AMONG WESTERNERS, IS FREQUENTLY USED TO IMPROVE PAINFUL CONDITIONS. WE INVESTIGATED POSSIBLE NEUROANATOMICAL UNDERPINNINGS OF THE BENEFICIAL EFFECTS OF YOGA USING SENSORY TESTING AND MAGNETIC RESONANCE IMAGING TECHNIQUES. NORTH AMERICAN YOGIS TOLERATED PAIN MORE THAN TWICE AS LONG AS INDIVIDUALLY MATCHED CONTROLS AND HAD MORE GRAY MATTER (GM) IN MULTIPLE BRAIN REGIONS. ACROSS SUBJECTS, INSULAR GM UNIQUELY CORRELATED WITH PAIN TOLERANCE. INSULAR GM VOLUME IN YOGIS POSITIVELY CORRELATED WITH YOGA EXPERIENCE, SUGGESTING A CAUSAL RELATIONSHIP BETWEEN YOGA AND INSULAR SIZE. YOGIS ALSO HAD INCREASED LEFT INTRAINSULAR WHITE MATTER INTEGRITY, CONSISTENT WITH A STRENGTHENED INSULAR INTEGRATION OF NOCICEPTIVE INPUT AND PARASYMPATHETIC AUTONOMIC REGULATION. YOGIS, AS OPPOSED TO CONTROLS, USED COGNITIVE STRATEGIES INVOLVING PARASYMPATHETIC ACTIVATION AND INTEROCEPTIVE AWARENESS TO TOLERATE PAIN, WHICH COULD HAVE LED TO USE-DEPENDENT HYPERTROPHY OF INSULAR CORTEX. TOGETHER, THESE FINDINGS SUGGEST THAT REGULAR AND LONG-TERM YOGA PRACTICE IMPROVES PAIN TOLERANCE IN TYPICAL NORTH AMERICANS BY TEACHING DIFFERENT WAYS TO DEAL WITH SENSORY INPUTS AND THE POTENTIAL EMOTIONAL REACTIONS ATTACHED TO THOSE INPUTS LEADING TO A CHANGE IN INSULAR BRAIN ANATOMY AND CONNECTIVITY.	2014	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
18 2720  29 YOGA MEDITATION PRACTITIONERS EXHIBIT GREATER GRAY MATTER VOLUME AND FEWER REPORTED COGNITIVE FAILURES: RESULTS OF A PRELIMINARY VOXEL-BASED MORPHOMETRIC ANALYSIS. HATHA YOGA TECHNIQUES, INCLUDING PHYSICAL POSTURES (ASANAS), BREATHING EXERCISES (PRANAYAMA), AND MEDITATION, INVOLVE THE PRACTICE OF MINDFULNESS. IN TURN, YOGA MEDITATION PRACTICES MAY INDUCE THE STATE OF MINDFULNESS, WHICH, WHEN EVOKED RECURRENTLY THROUGH REPEATED PRACTICE, MAY ACCRUE INTO TRAIT OR DISPOSITIONAL MINDFULNESS. PUTATIVELY, THESE CHANGES MAY BE MEDIATED BY EXPERIENCE-DEPENDENT NEUROPLASTIC CHANGES. THOUGH PRIOR STUDIES HAVE IDENTIFIED DIFFERENCES IN GRAY MATTER VOLUME (GMV) BETWEEN LONG-TERM MINDFULNESS PRACTITIONERS AND CONTROLS, NO STUDIES TO DATE HAVE REPORTED ON WHETHER YOGA MEDITATION IS ASSOCIATED WITH GMV DIFFERENCES. THE PRESENT STUDY INVESTIGATED GMV DIFFERENCES BETWEEN YOGA MEDITATION PRACTITIONERS (YMP) AND A MATCHED CONTROL GROUP (CG). THE YMP GROUP EXHIBITED GREATER GM VOLUME IN FRONTAL, LIMBIC, TEMPORAL, OCCIPITAL, AND CEREBELLAR REGIONS; WHEREAS THE CG HAD NO GREATER REGIONAL GREATER GMV. IN ADDITION, THE YMP GROUP REPORTED SIGNIFICANTLY FEWER COGNITIVE FAILURES ON THE COGNITIVE FAILURES QUESTIONNAIRE (CFQ), THE MAGNITUDE OF WHICH WAS POSITIVELY CORRELATED WITH GMV IN NUMEROUS REGIONS IDENTIFIED IN THE PRIMARY ANALYSIS. LASTLY, GMV WAS POSITIVELY CORRELATED WITH THE DURATION OF YOGA PRACTICE. RESULTS FROM THIS PRELIMINARY STUDY SUGGEST THAT HATHA YOGA PRACTICE MAY BE ASSOCIATED WITH THE PROMOTION OF NEUROPLASTIC CHANGES IN EXECUTIVE BRAIN SYSTEMS, WHICH MAY CONFER THERAPEUTIC BENEFITS THAT ACCRUE WITH REPEATED PRACTICE.	2012	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
19 1897  27 RESTING STATE FUNCTIONAL CONNECTIVITY ASSOCIATED WITH SAHAJA YOGA MEDITATION. NEUROSCIENCE RESEARCH HAS SHOWN THAT MEDITATION PRACTICES HAVE EFFECTS ON BRAIN STRUCTURE AND FUNCTION. HOWEVER, FEW STUDIES HAVE COMBINED INFORMATION ON THE EFFECTS ON STRUCTURE AND FUNCTION IN THE SAME SAMPLE. LONG-TERM DAILY MEDITATION PRACTICE PRODUCES REPEATED ACTIVITY OF SPECIFIC BRAIN NETWORKS OVER YEARS OF PRACTICE, WHICH MAY INDUCE LASTING STRUCTURAL AND FUNCTIONAL CONNECTIVITY (FC) CHANGES WITHIN RELEVANT CIRCUITS. THE AIM OF OUR STUDY WAS THEREFORE TO IDENTIFY DIFFERENCES IN FC DURING THE RESTING STATE BETWEEN 23 SAHAJA YOGA MEDITATION EXPERTS AND 23 HEALTHY PARTICIPANTS WITHOUT MEDITATION EXPERIENCE. SEED-BASED FC ANALYSIS WAS PERFORMED DEPARTING FROM VOXELS THAT HAD SHOWN STRUCTURAL DIFFERENCES BETWEEN THESE SAME PARTICIPANTS. THE CONTRAST OF CONNECTIVITY MAPS YIELDED THAT MEDITATORS SHOWED INCREASED FC BETWEEN THE LEFT VENTROLATERAL PREFRONTAL CORTEX AND THE RIGHT DORSOLATERAL PREFRONTAL CORTEX BUT REDUCED FC BETWEEN THE LEFT INSULA AND THE BILATERAL MID-CINGULATE AS WELL AS BETWEEN THE RIGHT ANGULAR GYRUS AND THE BILATERAL PRECUNEUS/CUNEUS CORTICES. IT THUS APPEARS THAT LONG-TERM MEDITATION PRACTICE INCREASES DIRECT FC BETWEEN VENTRAL AND DORSAL FRONTAL REGIONS WITHIN BRAIN NETWORKS RELATED TO ATTENTION AND COGNITIVE CONTROL AND DECREASES FC BETWEEN REGIONS OF THESE NETWORKS AND AREAS OF THE DEFAULT MODE NETWORK.	2021	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
20 1288  32 GREATER CORTICAL THICKNESS IN ELDERLY FEMALE YOGA PRACTITIONERS-A CROSS-SECTIONAL STUDY. YOGA, A MIND-BODY ACTIVITY THAT REQUIRES ATTENTIONAL ENGAGEMENT, HAS BEEN ASSOCIATED WITH POSITIVE CHANGES IN BRAIN STRUCTURE AND FUNCTION, ESPECIALLY IN AREAS RELATED TO AWARENESS, ATTENTION, EXECUTIVE FUNCTIONS AND MEMORY. NORMAL AGING, ON THE OTHER HAND, HAS ALSO BEEN ASSOCIATED WITH STRUCTURAL AND FUNCTIONAL BRAIN CHANGES, BUT THESE GENERALLY INVOLVE DECREASED COGNITIVE FUNCTIONS. THE AIM OF THIS CROSS-SECTIONAL STUDY WAS TO COMPARE BRAIN CORTICAL THICKNESS (CT) IN ELDERLY YOGA PRACTITIONERS AND A GROUP OF AGE-MATCHED HEALTHY NON-PRACTITIONERS. WE TESTED 21 OLDER WOMEN WHO HAD PRACTICED HATHA YOGA FOR AT LEAST 8 YEARS AND 21 WOMEN NAIVE TO YOGA, MEDITATION OR ANY MIND-BODY INTERVENTIONS WHO WERE MATCHED TO THE FIRST GROUP IN AGE, YEARS OF FORMAL EDUCATION AND PHYSICAL ACTIVITY LEVEL. A T1-WEIGHTED MPRAGE SEQUENCE WAS ACQUIRED FOR EACH PARTICIPANT. YOGA PRACTITIONERS SHOWED SIGNIFICANTLY GREATER CT IN A LEFT PREFRONTAL LOBE CLUSTER, WHICH INCLUDED PORTIONS OF THE LATERAL MIDDLE FRONTAL GYRUS, ANTERIOR SUPERIOR FRONTAL GYRUS AND DORSAL SUPERIOR FRONTAL GYRUS. WE FOUND GREATER CT IN THE LEFT PREFRONTAL CORTEX OF HEALTHY ELDERLY WOMEN WHO TRAINED YOGA FOR A MINIMUM OF 8 YEARS COMPARED WITH WOMEN IN THE CONTROL GROUP.	2017