1  743 162 EFFECT OF RESTORATIVE YOGA VS. STRETCHING ON DIURNAL CORTISOL DYNAMICS AND PSYCHOSOCIAL OUTCOMES IN INDIVIDUALS WITH THE METABOLIC SYNDROME: THE PRYSMS RANDOMIZED CONTROLLED TRIAL. PURPOSE: CHRONIC STIMULATION AND DYSREGULATION OF THE NEUROENDOCRINE SYSTEM BY STRESS MAY CAUSE METABOLIC ABNORMALITIES. WE ESTIMATED HOW MUCH CORTISOL AND PSYCHOSOCIAL OUTCOMES IMPROVED WITH A RESTORATIVE YOGA (RELAXATION) VERSUS A LOW IMPACT STRETCHING INTERVENTION FOR INDIVIDUALS WITH THE METABOLIC SYNDROME. METHODS: WE CONDUCTED A 1-YEAR MULTI-CENTER RANDOMIZED CONTROLLED TRIAL (6-MONTH INTERVENTION AND 6-MONTH MAINTENANCE PHASE) OF RESTORATIVE YOGA VS. STRETCHING. PARTICIPANTS COMPLETED SURVEYS TO ASSESS DEPRESSION, SOCIAL SUPPORT, POSITIVE AFFECT, AND STRESS AT BASELINE, 6 MONTHS AND 12 MONTHS. FOR EACH ASSESSMENT, WE COLLECTED SALIVA AT FOUR POINTS DAILY FOR THREE DAYS AND COLLECTED RESPONSE TO DEXAMETHASONE ON THE FOURTH DAY FOR ANALYSIS OF DIURNAL CORTISOL DYNAMICS. WE ANALYZED OUR DATA USING MULTIVARIATE REGRESSION MODELS, CONTROLLING FOR STUDY SITE, MEDICATIONS (ANTIDEPRESSANTS, HORMONE THERAPY), BODY MASS INDEX, AND BASELINE CORTISOL VALUES. RESULTS: PSYCHOSOCIAL OUTCOME MEASURES WERE AVAILABLE FOR 171 STUDY PARTICIPANTS AT BASELINE, 140 AT 6 MONTHS, AND 132 AT 1 YEAR. COMPLETE CORTISOL DATA WERE AVAILABLE FOR 136 OF 171 STUDY PARTICIPANTS (72 IN RESTORATIVE YOGA AND 64 IN STRETCHING) AND WERE ONLY AVAILABLE AT BASELINE AND 6 MONTHS. AT 6 MONTHS, THE STRETCHING GROUP HAD DECREASED CORTISOL AT WAKING AND BEDTIME COMPARED TO THE RESTORATIVE YOGA GROUP. THE PATTERN OF CHANGES IN STRESS MIRRORED THIS IMPROVEMENT, WITH THE STRETCHING GROUP SHOWING REDUCTIONS IN CHRONIC STRESS SEVERITY AND PERSEVERATIVE THOUGHTS ABOUT THEIR STRESS. PERCEIVED STRESS DECREASED BY 1.5 POINTS (-0.4; 3.3, P=0.11) AT 6 MONTHS, AND BY 2.0 POINTS (0.1; 3.9, P=0.04) AT 1 YEAR IN THE STRETCHING COMPARED TO RESTORATIVE YOGA GROUPS. POST HOC ANALYSES SUGGEST THAT IN THE STRETCHING GROUP ONLY, PERCEIVED INCREASES IN SOCIAL SUPPORT (PARTICULARLY FEELINGS OF BELONGING), BUT NOT CHANGES IN STRESS WERE RELATED TO IMPROVED CORTISOL DYNAMICS. CONCLUSIONS: WE FOUND SIGNIFICANT DECREASES IN SALIVARY CORTISOL, CHRONIC STRESS SEVERITY, AND STRESS PERCEPTION IN THE STRETCHING GROUP COMPARED TO THE RESTORATIVE YOGA GROUP. GROUP SUPPORT DURING THE INTERACTIVE STRETCH CLASSES MAY HAVE CONTRIBUTED TO THESE CHANGES.	2014	

2 1562  41 LONGITUDINAL AND IMMEDIATE EFFECT OF KUNDALINI YOGA ON SALIVARY LEVELS OF CORTISOL AND ACTIVITY OF ALPHA-AMYLASE AND ITS EFFECT ON PERCEIVED STRESS. CONTEXT: STRESS IS DEFINED AS AN ALTERATION OF AN ORGANISM'S BALANCE IN RESPONSE TO A DEMAND PERCEIVED FROM THE ENVIRONMENT. DIVERSE METHODS EXIST TO EVALUATE PHYSIOLOGICAL RESPONSE. A NONINVASIVE METHOD IS SALIVARY MEASUREMENT OF CORTISOL AND ALPHA-AMYLASE. A GROWING BODY OF EVIDENCE SUGGESTS THAT THE REGULAR PRACTICE OF YOGA WOULD BE AN EFFECTIVE TREATMENT FOR STRESS. AIMS: TO DETERMINE THE KUNDALINI YOGA (KY) EFFECT, IMMEDIATE AND AFTER 3 MONTHS OF REGULAR PRACTICE, ON THE PERCEPTION OF PSYCHOLOGICAL STRESS AND THE SALIVARY LEVELS OF CORTISOL AND ALPHA-AMYLASE ACTIVITY. SETTINGS AND DESIGN: TO DETERMINE THE PSYCHOLOGICAL PERCEIVED STRESS, LEVELS OF CORTISOL AND ALPHA-AMYLASE ACTIVITY IN SALIVA, AND COMPARE BETWEEN THE PARTICIPANTS TO KY CLASSES PERFORMED FOR 3 MONTHS AND A GROUP THAT DOES NOT PRACTICE ANY TYPE OF YOGA. SUBJECTS AND METHODS: THE TOTAL SAMPLE CONSISTED OF 26 PEOPLE BETWEEN 18 AND 45-YEAR-OLD; 13 TAKING PART IN KY CLASSES GIVEN AT THE FACULTY OF DENTISTRY, UNIVERSITY OF CHILE AND 13 CONTROLS. SALIVARY SAMPLES WERE COLLECTED, ENZYME-LINKED IMMUNOSORBENT ASSAY WAS PERFORMED TO QUANTIFY CORTISOL AND KINETIC REACTION TEST WAS MADE TO DETERMINE ALPHA-AMYLASE ACTIVITY. PERCEIVED STRESS SCALE WAS APPLIED AT THE BEGINNING AND AT THE END OF THE INTERVENTION. STATISTICAL ANALYSIS USED: STATISTICAL ANALYSIS WAS APPLIED USING STATA V11.1 SOFTWARE. SHAPIRO-WILK TEST WAS USED TO DETERMINE DATA DISTRIBUTION. THE PAIRED ANALYSIS WAS FULFILLED BY T-TEST OR WILCOXON SIGNED-RANK TEST. T-TEST OR MANN-WHITNEY'S TEST WAS APPLIED TO COMPARE LONGITUDINAL DATA. A STATISTICAL SIGNIFICANCE WAS CONSIDERED WHEN P < 0.05. RESULTS: KY PRACTICE HAD AN IMMEDIATE EFFECT ON SALIVARY CORTISOL. THE ACTIVITY OF ALPHA-AMYLASE DID NOT SHOW SIGNIFICANT CHANGES. A SIGNIFICANT DECREASE OF PERCEIVED STRESS IN THE STUDY GROUP WAS FOUND. CONCLUSIONS: KY PRACTICE SHOWS AN IMMEDIATE EFFECT ON SALIVARY CORTISOL LEVELS AND ON PERCEIVED STRESS AFTER 3 MONTHS OF PRACTICE.	2017	
                                                                                                                                                                                                                                                                                    
3  851  48 EFFECT OF YOGA ON SLEEP QUALITY AND NEUROENDOCRINE IMMUNE RESPONSE IN METASTATIC BREAST CANCER PATIENTS. BACKGROUND: STUDIES HAVE SHOWN THAT DISTRESS AND ACCOMPANYING NEUROENDOCRINE STRESS RESPONSES AS IMPORTANT PREDICTOR OF SURVIVAL IN ADVANCED BREAST CANCER PATIENTS. SOME PSYCHOTHERAPEUTIC INTERVENTION STUDIES HAVE SHOWN HAVE MODULATION OF NEUROENDOCRINE-IMMUNE RESPONSES IN ADVANCED BREAST CANCER PATIENTS. IN THIS STUDY, WE EVALUATE THE EFFECTS OF YOGA ON PERCEIVED STRESS, SLEEP, DIURNAL CORTISOL, AND NATURAL KILLER (NK) CELL COUNTS IN PATIENTS WITH METASTATIC CANCER. METHODS: IN THIS STUDY, 91 PATIENTS WITH METASTATIC BREAST CANCER WHO SATISFIED SELECTION CRITERIA AND CONSENTED TO PARTICIPATE WERE RECRUITED AND RANDOMIZED TO RECEIVE "INTEGRATED YOGA BASED STRESS REDUCTION PROGRAM" (N = 45) OR STANDARD "EDUCATION AND SUPPORTIVE THERAPY SESSIONS" (N = 46) OVER A 3 MONTH PERIOD. PSYCHOMETRIC ASSESSMENTS FOR SLEEP QUALITY WERE DONE BEFORE AND AFTER INTERVENTION. BLOOD DRAWS FOR NK CELL COUNTS WERE COLLECTED BEFORE AND AFTER THE INTERVENTION. SALIVA SAMPLES WERE COLLECTED FOR THREE CONSECUTIVE DAYS BEFORE AND AFTER INTERVENTION. DATA WERE ANALYZED USING THE ANALYSIS OF COVARIANCE ON POSTMEASURES USING RESPECTIVE BASELINE MEASURE AS A COVARIATE. RESULTS: THERE WAS A SIGNIFICANT DECREASE IN SCALES OF SYMPTOM DISTRESS (P < 0.001), SLEEP PARAMETERS (P = 0.02), AND IMPROVEMENT IN QUALITY OF SLEEP (P = 0.001) AND INSOMNIA RATING SCALE SLEEP SCORE (P = 0.001) FOLLOWING INTERVENTION. THERE WAS A DECREASE IN MORNING WAKING CORTISOL IN YOGA GROUP (P = 0.003) ALONE FOLLOWING INTERVENTION. THERE WAS A SIGNIFICANT IMPROVEMENT IN NK CELL PERCENT (P = 0.03) FOLLOWING INTERVENTION IN YOGA GROUP COMPARED TO CONTROL GROUP. CONCLUSION: THE RESULTS SUGGEST MODULATION OF NEUROENDOCRINE RESPONSES AND IMPROVEMENT IN SLEEP IN PATIENTS WITH ADVANCED BREAST CANCER FOLLOWING YOGA INTERVENTION.	2017	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
4  385  36 BENEFICIAL EFFECTS OF YOGA STRETCHING ON SALIVARY STRESS HORMONES AND PARASYMPATHETIC NERVE ACTIVITY. THIS STUDY AIMED TO DETERMINE THE EFFECT OF YOGA STRETCHING ON SALIVARY STRESS HORMONES AND CARDIAC AUTONOMIC NERVOUS SYSTEM. TO OUR KNOWLEDGE, THIS STUDY IS THE FIRST TO INVESTIGATE CHANGES IN CARDIAC AUTONOMIC NERVOUS SYSTEM AFTER YOGA STRETCHING. IN THIS CROSSOVER DESIGN STUDY, 10 ADULT MEN (AGE, 26.3 +/- 2.5 YEARS) WITHOUT YOGA EXPERIENCE PARTICIPATED IN THE REST AND YOGA TRIALS FOR 90 MIN. MEASUREMENTS WERE CARRIED OUT BEFORE (PRE), IMMEDIATELY (POST), 60 MIN, AND 120 MIN AFTER REST OR YOGA STRETCHING. SALIVA SAMPLES WERE COLLECTED BY CHEWING A STERILE COTTON BALL AT A FREQUENCY OF 60 CYCLES PER MINUTE. SALIVARY CORTISOL AND TESTOSTERONE CONCENTRATIONS WERE MEASURED USING AN ENZYME-LINKED IMMUNOSORBENT ASSAY. WITH THE SUBJECTS IN THE SITTING POSITION, HEART RATE VARIABILITY WAS MEASURED USING PULSE ANALYZER PLUS FOR 150 SECONDS. AS REGARDS RATE CHANGES, SALIVARY TESTOSTERONE LEVEL TENDED TO INCREASE (P = 0.088), TESTOSTERONE/CORTISOL RATIO SIGNIFICANTLY INCREASED (P < 0.05), AND CORTISOL LEVEL SIGNIFICANTLY DECREASED (P < 0.05) AT 120 MIN AFTER YOGA STRETCHING. THE SQUARE ROOT OF THE MEAN-SQUARED DIFFERENCES OF SUCCESSIVE NORMAL-TO-NORMAL INTERVALS AND NATURAL LOGARITHM HIGH-FREQUENCY COMPONENT, WHICH ARE INDICATORS OF PARASYMPATHETIC NERVE ACTIVITY, INCREASED AT 60 MIN (P < 0.05) AND 120 MIN (P < 0.05) IN THE YOGA TRIAL, RESPECTIVELY. IN CONCLUSION, YOGA STRETCHING CAN ENHANCE PARASYMPATHETIC NERVE ACTIVITY AND IMPROVE STRESS HORMONES. THEREFORE, YOGA STRETCHING MAY BE USEFUL TO COMPENSATE FOR PHYSICAL INACTIVITY AND INCREASE LIFE EXPECTANCY IN THE GENERAL POPULATION.	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
5 2778  22 YOGA STRETCHING FOR IMPROVING SALIVARY IMMUNE FUNCTION AND MENTAL STRESS IN MIDDLE-AGED AND OLDER ADULTS. PROTECTION AGAINST AGE-RELATED IMMUNE SUPPRESSION IS IMPORTANT IN ELDERLY INDIVIDUALS. THIS STUDY DETERMINED THE EFFECT OF YOGA ON MUCOSAL IMMUNE FUNCTION AND MENTAL STRESS. SALIVA SAMPLES WERE COLLECTED FROM 23 ADULT WOMEN (AGE: 60.4 +/- 10.4 YEARS) BEFORE AND AFTER 90 MINUTES OF YOGA STRETCHING OR REST TO MEASURE SECRETORY IMMUNOGLOBULIN A (SIGA), CORTISOL, AND TESTOSTERONE. THE SIGA CONCENTRATION AND SECRETION RATE WERE SIGNIFICANTLY HIGHER AFTER YOGA THAN BEFORE (P < .05). THE CORTISOL CONCENTRATION AND SECRETION RATE WERE LOWER AND TESTOSTERONE SECRETION RATE HIGHER AFTER YOGA (P < .05). YOGA STRETCHING CAN REDUCE STRESS AND ENHANCE MUCOSAL IMMUNE FUNCTION IN ELDERLY WOMEN.	2018	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
6  984  48 EFFECTS OF HATHA YOGA AND AFRICAN DANCE ON PERCEIVED STRESS, AFFECT, AND SALIVARY CORTISOL. BACKGROUND: DANCE AND YOGA HAVE BEEN SHOWN TO PRODUCE IMPROVEMENTS IN PSYCHOLOGICAL WELL-BEING. PURPOSE: THE AIM OF THIS STUDY WAS TO EXAMINE SOME OF THE PSYCHOLOGICAL AND NEUROENDOCRINE RESPONSE TO THESE ACTIVITIES. METHODS: SIXTY-NINE HEALTHY COLLEGE STUDENTS PARTICIPATED IN ONE OF THREE 90-MIN CLASSES: AFRICAN DANCE (N = 21), HATHA YOGA (N= 18), OR A BIOLOGY LECTURE AS A CONTROL SESSION (N = 30). BEFORE AND AFTER EACH CONDITION PARTICIPANTS COMPLETED THE PERCEIVED STRESS SCALE (PSS), COMPLETED THE POSITIVE AFFECT AND NEGATIVE AFFECT SCHEDULE, AND PROVIDED A SALIVA SAMPLE FOR CORTISOL. RESULTS: THERE WERE SIGNIFICANT REDUCTIONS IN PSS AND NEGATIVE AFFECT (PS < .0001) AND TIME X TREATMENT INTERACTIONS (PS < .0001) SUCH THAT AFRICAN DANCE AND HATHA YOGA SHOWED SIGNIFICANT DECLINES, WHEREAS THERE WAS NO SIGNIFICANT CHANGE IN BIOLOGY LECTURE. THERE WAS NO SIGNIFICANT MAIN EFFECT FOR POSITIVE AFFECT (P = .53), HOWEVER THERE WAS A SIGNIFICANT INTERACTION EFFECT (P < .001) SUCH THAT POSITIVE AFFECT INCREASED IN AFRICAN DANCE, DECREASED IN BIOLOGY LECTURE, AND DID NOT CHANGE SIGNIFICANTLY IN HATHA YOGA. THERE WAS A SIGNIFICANT MAIN EFFECT FOR SALIVARY CORTISOL (P < .05) AND A SIGNIFICANT INTERACTION EFFECT (P < .0001) SUCH THAT CORTISOL INCREASED IN AFRICAN DANCE, DECREASED IN HATHA YOGA, AND DID NOT CHANGE IN BIOLOGY. CHANGES IN CORTISOL WERE NOT SIGNIFICANTLY RELATED TO CHANGES IN PSYCHOLOGICAL VARIABLES ACROSS TREATMENTS. THERE WAS 1 SIGNIFICANT INTERACTION EFFECT (P = .04) SUCH THAT CHANGE IN POSITIVE AFFECT AND CHANGE IN CORTISOL WERE NEGATIVELY CORRELATED IN HATHA YOGA BUT POSITIVELY CORRELATED IN AFRICA DANCE AND BIOLOGY. CONCLUSIONS: BOTH AFRICAN DANCE AND HATHA YOGA REDUCED PERCEIVED STRESS AND NEGATIVE AFFECT. CORTISOL INCREASED IN AFRICAN DANCE AND DECREASED IN HATHA YOGA. THEREFORE, EVEN WHEN THESE INTERVENTIONS PRODUCE SIMILAR POSITIVE PSYCHOLOGICAL EFFECTS, THE EFFECTS MAY BE VERY DIFFERENT ON PHYSIOLOGICAL STRESS PROCESSES. ONE FACTOR THAT MAY HAVE PARTICULAR SALIENCE IS THAT AMOUNT OF PHYSIOLOGICAL AROUSAL PRODUCED BY THE INTERVENTION.	2004	
                                                                                                                                                                                                                               
7  962  36 EFFECTS OF A YOGA PROGRAM ON CORTISOL RHYTHM AND MOOD STATES IN EARLY BREAST CANCER PATIENTS UNDERGOING ADJUVANT RADIOTHERAPY: A RANDOMIZED CONTROLLED TRIAL. UNLABELLED: OBJECTIVES. THIS STUDY COMPARES THE EFFECTS OF AN INTEGRATED YOGA PROGRAM WITH BRIEF SUPPORTIVE THERAPY IN BREAST CANCER OUTPATIENTS UNDERGOING ADJUVANT RADIOTHERAPY AT A CANCER CENTER. METHODS: EIGHTY-EIGHT STAGE II AND III BREAST CANCER OUTPATIENTS ARE RANDOMLY ASSIGNED TO RECEIVE YOGA (N = 44) OR BRIEF SUPPORTIVE THERAPY (N = 44) PRIOR TO RADIOTHERAPY TREATMENT. ASSESSMENTS INCLUDE DIURNAL SALIVARY CORTISOL LEVELS 3 DAYS BEFORE AND AFTER RADIOTHERAPY AND SELF-RATINGS OF ANXIETY, DEPRESSION, AND STRESS COLLECTED BEFORE AND AFTER 6 WEEKS OF RADIOTHERAPY. RESULTS: ANALYSIS OF COVARIANCE REVEALS SIGNIFICANT DECREASES IN ANXIETY (P < .001), DEPRESSION (P = .002), PERCEIVED STRESS (P < .001), 6 A.M. SALIVARY CORTISOL (P = .009), AND POOLED MEAN CORTISOL (P = .03) IN THE YOGA GROUP COMPARED WITH CONTROLS. THERE IS A SIGNIFICANT POSITIVE CORRELATION BETWEEN MORNING SALIVARY CORTISOL LEVEL AND ANXIETY AND DEPRESSION. CONCLUSION: YOGA MIGHT HAVE A ROLE IN MANAGING SELF-REPORTED PSYCHOLOGICAL DISTRESS AND MODULATING CIRCADIAN PATTERNS OF STRESS HORMONES IN EARLY BREAST CANCER PATIENTS UNDERGOING ADJUVANT RADIOTHERAPY.	2009	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
8 1361  41 IMMEDIATE STRESS REDUCTION EFFECTS OF YOGA DURING PREGNANCY: ONE GROUP PRE-POST TEST. BACKGROUND: EXCESSIVE STRESS DURING PREGNANCY MAY CAUSE MENTAL DISORDERS IN PREGNANT WOMEN AND INHIBIT FETAL GROWTH. YOGA MAY ALLEVIATE STRESS DURING PREGNANCY. AIM: TO VERIFY THE IMMEDIATE EFFECTS OF YOGA ON STRESS RESPONSE DURING PREGNANCY. METHODS: ONE GROUP PRE-POST TEST WAS CONDUCTED AT A HOSPITAL IN JAPAN. WE RECRUITED 60 HEALTHY PRIMIPARAS WITHOUT COMPLICATIONS AND ASKED THEM TO ATTEND YOGA CLASSES TWICE A MONTH AND TO PRACTICE YOGA AT THEIR HOMES USING DVD 3 TIMES A WEEK FROM 20 GESTATIONAL WEEKS UNTIL CHILDBIRTH. SALIVARY CORTISOL AND ALPHA-AMYLASE CONCENTRATION WERE MEASURED BEFORE AND AFTER YOGA CLASSES AT TIME 1 (27-32 GESTATIONAL WEEKS) AND TIME 2 (34-37 GESTATIONAL WEEKS). SUBJECTIVE MOOD WAS ASSESSED USING THE PROFILE OF MOOD STATES. SALIVA VALUES AND MOOD SCORES BEFORE AND AFTER EACH YOGA CLASS WERE COMPARED USING PAIRED T-TEST AND WILCOXON RANK-SUM TEST, RESPECTIVELY. FINDINGS: WE ANALYZED 44 AND 35 WOMEN AT TIME 1 AND TIME 2, RESPECTIVELY. THE MEAN SALIVARY CORTISOL CONCENTRATION DECLINED SIGNIFICANTLY AFTER EACH YOGA CLASS [TIME 1: 0.36-0.26MUG/DL (P<0.001), TIME 2: 0.32-0.26MUG/DL (P=0.001)]. THE MEAN SALIVARY ALPHA-AMYLASE CONCENTRATION ALSO DECREASED SIGNIFICANTLY FOLLOWING EACH CLASS [TIME 1: 72.2-50.8KU/L (P=0.001), TIME 2: 70.6-52.7KU/L (P=0.006)]. THE SCORES FOR NEGATIVE DIMENSIONS OF MOOD (TRAIT-ANXIETY, DEPRESSION, ANGER-HOSTILITY, FATIGUE, AND CONFUSION) DECREASED SIGNIFICANTLY. THE SCORES OF VIGOR FOR A POSITIVE DIMENSION OF MOOD SIGNIFICANTLY INCREASED. CONCLUSION: THIS STUDY INDICATED THE IMMEDIATE STRESS REDUCTION EFFECTS OF YOGA DURING PREGNANCY.	2016	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
9 2743  44 YOGA PRACTICE IMPROVES EXECUTIVE FUNCTION BY ATTENUATING STRESS LEVELS. BACKGROUND: PROLONGED ACTIVATION OF THE HYPOTHALAMUS-PITUITARY-ADRENAL SYSTEM IS THOUGHT TO HAVE DELETERIOUS EFFECTS ON BRAIN FUNCTION. NEUROENDOCRINE STUDIES SUGGEST THAT BRAIN EXPOSURE TO HIGHER CORTISOL CONCENTRATIONS CONTRIBUTE TO COGNITIVE DEFICITS AS WE AGE. MIND-BODY TECHNIQUES SUCH AS YOGA HAVE SHOWN TO IMPROVE STRESS LEVELS BY RESTORING THE BODY'S SYMPATHETIC-PARASYMPATHETIC BALANCE. THE OBJECTIVE OF THIS STUDY WAS TO DETERMINE WHETHER YOGA PRACTICE MODERATED THE STRESS RESPONSE RESULTING IN IMPROVED EXECUTIVE FUNCTION. METHODS: SEDENTARY COMMUNITY DWELLING OLDER ADULTS (N=118, MEAN AGE=62.02) WERE RANDOMIZED TO AN 8-WEEK YOGA INTERVENTION OR A STRETCHING CONTROL GROUP. AT BASELINE AND FOLLOWING 8 WEEKS, ALL PARTICIPANTS COMPLETED MEASURES OF EXECUTIVE FUNCTION, SELF-REPORTED STRESS AND ANXIETY AND PROVIDED SALIVA SAMPLES BEFORE AND AFTER COGNITIVE TESTING TO ASSESS CORTISOL. RESULTS: YOGA PARTICIPANTS SHOWED IMPROVED ACCURACY ON EXECUTIVE FUNCTION MEASURES AND AN ATTENUATED CORTISOL RESPONSE COMPARED TO THEIR STRETCHING COUNTERPARTS WHO SHOWED INCREASED CORTISOL LEVELS AND POOR COGNITIVE PERFORMANCE AT FOLLOW UP. THE CHANGE IN CORTISOL LEVELS AS WELL AS SELF-REPORTED STRESS AND ANXIETY LEVELS PREDICTED PERFORMANCE ON THE RUNNING SPAN TASK, N-BACK WORKING MEMORY AND TASK SWITCHING PARADIGM (BETA'S=0.27-0.38, P'S</=0.05 FOR YOGA AND BETA'S=-0.37-0.47, P'S</=0.01 FOR STRETCHING CONTROL). CONCLUSION: EIGHT WEEKS OF REGULAR YOGA PRACTICE RESULTED IN IMPROVED WORKING MEMORY PERFORMANCE THAT WAS MEDIATED BY AN ATTENUATED RESPONSE TO STRESS AS MEASURED BY SELF-REPORT STRESS AND OBJECTIVE SALIVARY CORTISOL MEASUREMENTS. THIS TRIAL OFFERS EVIDENCE FOR NON-TRADITIONAL PHYSICAL ACTIVITY INTERVENTIONS SUCH AS YOGA THAT MAY BE HELPFUL IN RESTORING HPA BALANCE IN OLDER ADULTS, THEREBY PREVENTING COGNITIVE DECLINE.	2016	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
10 1036  36 EFFECTS OF YOGA IN MANAGING FATIGUE IN BREAST CANCER PATIENTS: A RANDOMIZED CONTROLLED TRIAL. BACKGROUND: CANCER-RELATED FATIGUE IS WIDELY PREVALENT IN CANCER PATIENTS AND AFFECTS QUALITY OF LIFE IN ADVANCED CANCER PATIENTS. FATIGUE IS CAUSED DUE TO BOTH PSYCHOLOGIC DISTRESS AND PHYSIOLOGICAL SEQUEL FOLLOWING CANCER PROGRESSION AND ITS TREATMENT. IN THIS STUDY, WE EVALUATE THE EFFECTS OF YOGIC INTERVENTION IN MANAGING FATIGUE IN METASTATIC BREAST CANCER PATIENTS. METHODS: NINETY-ONE PATIENTS WITH METASTATIC BREAST CANCER WERE RANDOMIZED TO RECEIVE INTEGRATED YOGA PROGRAM (N = 46) OR SUPPORTIVE THERAPY AND EDUCATION (N = 45) OVER A 3-MONTH PERIOD. ASSESSMENTS SUCH AS PERCEIVED STRESS, FATIGUE SYMPTOM INVENTORY, DIURNAL SALIVARY CORTISOL, AND NATURAL KILLER CELL COUNTS WERE CARRIED OUT BEFORE AND AFTER INTERVENTION. ANALYSIS WAS DONE USING AN INTENTION-TO-TREAT APPROACH. POSTMEASURES FOR THE ABOVE OUTCOMES WERE ASSESSED USING ANCOVA WITH RESPECTIVE BASELINE MEASURE AS A COVARIATE. RESULTS: THE RESULTS SUGGEST THAT YOGA REDUCES PERCEIVED STRESS (P = 0.001), FATIGUE FREQUENCY (P < 0.001), FATIGUE SEVERITY (P < 0.001), INTERFERENCE (P < 0.001), AND DIURNAL VARIATION (P < 0.001) WHEN COMPARED TO SUPPORTIVE THERAPY. THERE WAS A POSITIVE CORRELATION OF CHANGE IN FATIGUE SEVERITY WITH 9 A.M. SALIVARY CORTISOL LEVELS. CONCLUSION: THE RESULTS SUGGEST THAT YOGA REDUCES FATIGUE IN ADVANCED BREAST CANCER PATIENTS.	2017	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
11  720  40 EFFECT OF IYENGAR YOGA PRACTICE ON FATIGUE AND DIURNAL SALIVARY CORTISOL CONCENTRATION IN BREAST CANCER SURVIVORS. PURPOSE: TO EXAMINE THE EFFECT OF REGULAR IYENGAR YOGA PRACTICE ON MEASURES OF SELF-PERCEIVED PSYCHOSOCIAL FUNCTION AND DIURNAL SALIVARY CORTISOL SECRETION IN STAGE II-IV BREAST CANCER SURVIVORS (N = 18). DATA SOURCES: WOMEN WERE RANDOMLY ASSIGNED TO ATTEND YOGA PRACTICE FOR 90 MIN TWICE WEEKLY FOR 8 WEEKS (N = 9) OR TO A WAIT-LISTED, NONINTERVENTIONAL CONTROL GROUP (N = 9). TRADITIONAL IYENGAR YOGA ROUTINES THAT PROGRESSIVELY INCREASED IN DIFFICULTY AS PARTICIPANTS GAINED STRENGTH AND FLEXIBILITY WERE USED. AT BASELINE AND AFTER THE 8-WEEK STUDY PERIOD, WOMEN COMPLETED SELF-REPORT INSTRUMENTS TO DOCUMENT VARIOUS ASPECTS OF PSYCHOSOCIAL AND PHYSICAL FUNCTIONING, AND COLLECTED SALIVARY SAMPLES FOR CORTISOL ANALYSIS FOUR TIMES DURING THE DAY FOR TWO CONSECUTIVE DAYS. CONCLUSIONS: THE YOGA GROUP HAD LOWER MORNING AND 5 P.M. SALIVARY CORTISOL AND IMPROVED EMOTIONAL WELL-BEING AND FATIGUE SCORES. IMPLICATIONS FOR PRACTICE: BREAST CANCER SURVIVORS ARE AT RISK FOR CHRONIC PSYCHOSOCIAL DISTRESS THAT MAY ALTER ACTIVITY OF THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS, RESULTING IN ABERRANT REGULATION OF CORTISOL SECRETION AND INCREASED RISK OF IMMUNE DYSFUNCTION AND CANCER PROGRESSION. REGULAR YOGA PRACTICE MAY BE A LOW-RISK, COST-EFFECTIVE WAY TO IMPROVE PSYCHOSOCIAL FUNCTIONING, FATIGUE, AND REGULATION OF CORTISOL SECRETION IN BREAST CANCER SURVIVORS. THESE FINDINGS REQUIRE VALIDATION WITH A LARGER RANDOMIZED STUDY.	2011	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
12  169  47 A RANDOMIZED CONTROLLED PILOT STUDY ASSESSING FEASIBILITY AND IMPACT OF YOGA PRACTICE ON QUALITY OF LIFE, MOOD, AND PERCEIVED STRESS IN WOMEN WITH NEWLY DIAGNOSED BREAST CANCER. BACKGROUND: A BREAST CANCER DIAGNOSIS CAN ENTAIL NUMEROUS PHYSICAL AND PSYCHOSOCIAL CHALLENGES. YOGA PRACTICE (YP) MAY CONTRIBUTE TO IMPROVED WELL-BEING FOR THESE PATIENTS. PRIMARY STUDY OBJECTIVE: INVESTIGATE FEASIBILITY AND IMPACT OF YP ON QUALITY OF LIFE (QOL), MOOD, FATIGUE, AND PERCEIVED STRESS IMMEDIATELY AFTER BREAST CANCER DIAGNOSIS. METHODS: THIRTY WOMEN WERE RANDOMLY ASSIGNED TO A YOGA GROUP (YG) OR CONTROL GROUP (CG) IMMEDIATELY AFTER CANCER DIAGNOSIS. SETTING: PILOT STUDY CONDUCTED AT AN ACADEMIC MEDICAL CENTER BREAST CLINIC. PARTICIPANTS: FEMALES (N = 30) WHO RECEIVED A BIOPSY-PROVEN BREAST CANCER DIAGNOSIS WITHOUT METASTATIC DISEASE. INTERVENTION YG: ONE INDIVIDUAL YP SESSION AT BASELINE, THEN 2 INDIVIDUAL AND 8 WEEKLY GROUP SESSIONS FOLLOWED BY WEEKLY GENTLE YOGA AT HOME (DVD). QUESTIONNAIRES AND SALIVA SAMPLES (IE, CORTISOL) COMPLETED AT BASELINE AND 12 WEEKS POSTDIAGNOSIS. RESULTS: BOTH GROUPS REPORTED SIGNIFICANT IMPROVEMENTS IN QOL POSTINTERVENTION BUT WITH NO SIGNIFICANT DIFFERENCE BETWEEN GROUPS. EMOTIONAL WELL-BEING, MOOD-RELATED TENSION-ANXIETY, DEPRESSION-DEJECTION, AND CONFUSION-BEWILDERMENT SCORES IMPROVED FOR BOTH GROUPS, AND CORTISOL AND CORTISONE LEVELS DECREASED. LUMPECTOMIES WERE PREVALENT WITH YG (67%) AND CG (47%). YP WAS RATED AS "VERY EFFECTIVE," PROVIDING RELAXATION (85%), STRESS RELIEF (69%), AND REDUCED MUSCLE TENSION/GENERAL FEELING OF WELLNESS (EACH 62%). CONCLUSION: FEASIBILITY OF YP IMMEDIATELY AFTER BREAST CANCER DIAGNOSIS WAS GOOD. IMPROVEMENT IN EMOTIONAL WELL-BEING, ANXIETY, DEPRESSION, AND LEVELS OF CONFUSION WAS FOUND IN BOTH GROUPS. TO OUR KNOWLEDGE, THIS IS THE FIRST STUDY EXAMINING THE IMPACT OF YP IMMEDIATELY AFTER BREAST CANCER DIAGNOSIS. FURTHER RESEARCH IN THIS AREA IS WARRANTED.	2012	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
13 2149  25 THE EFFECTS OF POWER AND STRETCH YOGA ON AFFECT AND SALIVARY CORTISOL IN WOMEN. YOGA PRACTICE IS KNOWN TO IMPROVE WELL-BEING AND DECREASE STRESS. HOWEVER, ACUTE YOGA IS UNDERSTUDIED. THIS STUDY INVESTIGATED THE EFFECTS OF TWO DIFFERENT TYPES OF YOGA ON AFFECT AND SALIVARY CORTISOL LEVELS IN COLLEGE WOMEN. THIRTY-THREE WOMEN AGED 18-30 YEARS EACH COMPLETED 1-HOUR SESSIONS OF POWER YOGA AND STRETCH YOGA. MEASURES OF AFFECT AND SALIVARY CORTISOL WERE ASSESSED BEFORE, DURING, AND AFTER EACH SESSION. PARTICIPANTS PERCEIVED POWER YOGA TO BE MORE PLEASURABLE AND ENERGIZING. SALIVARY CORTISOL SIGNIFICANTLY DECREASED AFTER BOTH YOGA SESSIONS. THUS, EVEN ONE SESSION OF YOGA MAY BE EFFECTIVE IN IMPROVING AFFECT AND DECREASING STRESS IN COLLEGE WOMEN.	2019	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
14  723  38 EFFECT OF LAUGHTER YOGA ON MENTAL SYMPTOMS AND SALIVARY CORTISOL LEVELS IN FIRST-YEAR NURSING STUDENTS: A RANDOMIZED CONTROLLED TRIAL. BACKGROUND: UNIVERSITY STUDENTS ARE FACED WITH SEVERAL STRESS FACTORS AFFECTING THEIR MENTAL HEALTH. THEREFORE, THE FIRST YEAR AT UNIVERSITY IS A PERIOD THAT CALLS FOR CAREFUL ATTENTION AND RESEARCH. AIM: THE AIM OF THIS STUDY IS TO EVALUATE THE EFFECT OF LAUGHTER YOGA ON MENTAL SYMPTOMS AND CORTISOL LEVELS IN NURSING STUDENTS. METHODS: THIS STUDY IS A RANDOMIZED CONTROLLED STUDY EMPLOYING A PRE-/POST-TEST DESIGN WITH A CONTROL GROUP. A TOTAL OF 75 HEALTHY UNIVERSITY STUDENTS WERE ASSIGNED TO THE INTERVENTION GROUP AND CONTROL GROUP. THE BRIEF SYMPTOM INVENTORY WAS APPLIED TO BOTH GROUPS BEFORE SESSION 1 AND AFTER SESSION 8. SALIVA SAMPLES WERE TAKEN FROM THE STUDENTS TO MEASURE THEIR CORTISOL LEVELS BEFORE AND AFTER EACH SESSION. RESULTS: EVALUATION OF THE MEAN SCORES OBTAINED FROM THE BRIEF SYMPTOM INVENTORY BEFORE AND AFTER THE INTERVENTION SHOWED A SIGNIFICANT DECREASE IN THE SCORES BETWEEN GROUPS (P < 0.05). IN THREE OUT OF THE EIGHT SESSIONS, THERE WAS A SIGNIFICANT DECREASE IN THE INTERVENTION GROUP COMPARED WITH THE CONTROL GROUP REGARDING THE MEAN VALUES OF PRE-TEST AND POST-TEST SALIVARY CORTISOL LEVELS (P < 0.05). CONCLUSION: LAUGHTER YOGA CAN PROVIDE AN EFFECTIVE MEANS TO HELP FIRST-YEAR NURSING STUDENTS COPE WITH STRESS AND REDUCE MENTAL SYMPTOMS.	2021	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
15  988  39 EFFECTS OF HATHA YOGA ON BLOOD PRESSURE, SALIVARY ALPHA-AMYLASE, AND CORTISOL FUNCTION AMONG NORMOTENSIVE AND PREHYPERTENSIVE YOUTH. OBJECTIVE: EVIDENCE IS ACCUMULATING, PREDOMINANTLY AMONG CLINICAL TRIALS IN ADULTS, THAT YOGA IMPROVES BLOOD PRESSURE (BP) CONTROL, WITH DOWNREGULATION OF THE HYPOTHALAMIC-PITUITARY-ADRENAL (HPA) AXIS AND THE SYMPATHETIC NERVOUS SYSTEM (SNS) PROJECTED AS UNDERLYING MECHANISMS. THIS PILOT STUDY ASSESSED WHETHER HATHA YOGA HAS THE POTENTIAL TO REDUCE BP AMONG YOUTH AND WHETHER DAMPENING OF THE SNS AND/OR HPA ACTIVITY IS A LIKELY PATHWAY OF CHANGE. DESIGN: THIRTY-ONE SEVENTH GRADERS WERE RANDOMLY ASSIGNED TO A HATHA YOGA PROGRAM (HYP) OR ATTENTION CONTROL (AC) MUSIC OR ART CLASS. BASELINE AND 3-MONTH EVALUATIONS INCLUDED RESTING BP; OVERNIGHT URINE SAMPLES; AND SALIVA COLLECTED AT BEDTIME, UPON AWAKENING, AND AT 30 AND 60 MINUTES AFTER AWAKENING FOR ALPHA-AMYLASE AND CORTISOL ASSAYS. RESULTS: TWENTY-EIGHT (14 IN THE HYP GROUP AND 14 IN THE AC GROUP) STUDENTS WERE ASSESSED BOTH BEFORE AND AFTER THE INTERVENTION. BP CHANGES FROM PRE- TO POST-INTERVENTION WERE -3.0/-2.0 MMHG FOR THE HYP GROUP AND -0.07/-0.79 MMHG FOR THE AC GROUP (P=0.30 AND 0.57, RESPECTIVELY). CHANGES IN SYSTOLIC BP (SBP)/DIASTOLIC BP (DBP) FOR THE PREHYPERTENSIVE (75TH-94TH PERCENTILES FOR SBP) SUBGROUP ANALYSES WERE -10.75/-8.25 MMHG FOR THE HYP GROUP (N=4) VERSUS 1.8/1.0 MMHG FOR THE AC GROUP (N=5) (P FOR SBP=0.02; P FOR DBP=0.09). ALTHOUGH NO STATISTICALLY SIGNIFICANT GROUP DIFFERENCES WERE OBSERVED WITH CHANGES IN SNS OR HPA AWAKENING CURVES (AREA UNDER CURVE FOR ALPHA-AMYLASE AND CORTISOL, RESPECTIVELY), A SMALL TO MODERATE EFFECT SIZE WAS SEEN FAVORING A REDUCTION OF ALPHA-AMYLASE ACTIVATION FOR THE HYP GROUP (COHEN D=0.34; PREHYPERTENSIVE D=0.20). CONCLUSIONS: A SCHOOL-BASED HATHA YOGA PROGRAM DEMONSTRATED POTENTIAL TO DECREASE RESTING BP, PARTICULARLY AMONG PREHYPERTENSIVE YOUTH. REDUCED SNS DRIVE MAY BE AN UNDERLYING NEUROHORMONAL PATHWAY BENEFICIALLY AFFECTED BY THE PROGRAM. A LARGE-SCALE EFFICACY/EFFECTIVENESS RANDOMIZED CLINICAL TRIAL IS WARRANTED.	2014	
                                                                                                                                                                                                                                                                                                                 
16 1390  33 IMPACT OF SUDARSHAN KRIYA YOGA ON SALIVARY PH: AN EXPLORATORY PILOT STUDY. INTRODUCTION: SALIVA IS INCREASINGLY USED AS A DIAGNOSTIC TOOL AS IT IS NON-INVASIVE, EASILY ACCESSIBLE, AND LESS STRESSFUL COMPARED TO BLOOD SAMPLING. SALIVA HAS A VITAL ROLE IN MAINTAINING ORAL HEALTH. IT IS NECESSARY FOR THE SALIVARY PH TO BE NEUTRAL IN THE ORAL CAVITY FOR THE OPTIMAL FUNCTIONING OF ITS COMPONENTS. STRESS HAS AN EFFECT ON SALIVARY PH. OBJECTIVE: TO STUDY THE EFFECT OF A MIND-BODY INTERVENTION LIKE SUDARSHAN KRIYA YOGA (SKY) ON THE SALIVARY PH. METHODS AND MATERIALS: AN EXPLORATORY PILOT STUDY INVOLVING AN OPEN TRIAL ON 321 HEALTHY INDIVIDUALS WHO WERE NOVICE TO SKY WAS CONDUCTED. THE SALIVARY PH WAS MEASURED BEFORE AND AFTER A SINGLE 90-MIN SESSION OF SKY. RESULTS: THE SALIVARY PH CONTINUED TO BE NEUTRAL AFTER THE INTERVENTION IN THE GROUP THAT HAD INITIAL NEUTRAL PH. THERE WAS A STATISTICALLY SIGNIFICANT SHIFT OF PH TOWARDS NEUTRAL IN BOTH THE GROUPS THAT HAD EITHER ACIDIC OR ALKALINE PH INITIALLY. CONCLUSION: MIND-BODY INTERVENTIONS LIKE SKY MODULATE THE SALIVARY PH TO BRING IT TO THE RANGE OF OPTIMAL FUNCTIONING. THIS PILOT STUDY PROVIDES INFORMATION FOR FUTURE LONG-TERM STUDIES THAT CAN BE IMPLEMENTED WITH MEASURES OF ANXIETY AND STRESS ALONG WITH MEASURING OTHER SALIVARY BIOMARKERS.	2021	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
17 2089  30 THE EFFECT OF PRENATAL HATHA YOGA ON AFFECT, CORTISOL AND DEPRESSIVE SYMPTOMS. PERINATAL DEPRESSION IMPACTS MATERNAL AND CHILD HEALTH, AND LITTLE IS KNOWN ABOUT EFFECTIVE INTERVENTIONS. THE EFFECTS OF PRENATAL HATHA YOGA ON CORTISOL, AFFECT AND DEPRESSIVE SYMPTOMS WERE INVESTIGATED IN 51 WOMEN. TWICE DURING PREGNANCY, YOGA GROUP PARTICIPANTS REPORTED ON AFFECT AND PROVIDED A SALIVA SAMPLE BEFORE AND AFTER A 90-MIN PRENATAL HATHA YOGA SESSION. CORRESPONDING MEASURES WERE OBTAINED FROM YOGA AND CONTROL GROUP PARTICIPANTS ON DAYS OF USUAL ACTIVITY. DEPRESSIVE SYMPTOMS WERE ASSESSED IN PREGNANCY AND POST PARTUM. CORTISOL WAS LOWER (P < .01) AND POSITIVE AFFECT HIGHER (P < .001) ON YOGA COMPARED TO USUAL ACTIVITY DAYS. NEGATIVE AFFECT AND CONTENTMENT (P < .05) IMPROVED MORE IN RESPONSE TO THE YOGA SESSION. YOGA GROUP PARTICIPANTS SHOWED FEWER POSTPARTUM (P < .05) BUT NOT ANTEPARTUM DEPRESSIVE SYMPTOMS THAN CONTROL GROUP PARTICIPANTS. FINDINGS INDICATE THAT PRENATAL HATHA YOGA MAY IMPROVE CURRENT MOOD AND MAY BE EFFECTIVE IN REDUCING POSTPARTUM DEPRESSIVE SYMPTOMS.	2014	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
18 1015  39 EFFECTS OF PRENATAL YOGA ON WOMEN'S STRESS AND IMMUNE FUNCTION ACROSS PREGNANCY: A RANDOMIZED CONTROLLED TRIAL. OBJECTIVE: THE EFFECTS OF PRENATAL YOGA ON BIOLOGICAL INDICATORS HAVE NOT BEEN WIDELY STUDIED. THUS, WE COMPARED CHANGES IN STRESS AND IMMUNITY SALIVARY BIOMARKERS FROM 16 TO 36 WEEKS' GESTATION BETWEEN WOMEN RECEIVING PRENATAL YOGA AND THOSE RECEIVING ROUTINE PRENATAL CARE. DESIGN: FOR THIS LONGITUDINAL, PROSPECTIVE, RANDOMIZED CONTROLLED TRIAL, WE RECRUITED 94 HEALTHY PREGNANT WOMEN AT 16 WEEKS' GESTATION THROUGH CONVENIENCE SAMPLING FROM A PRENATAL CLINIC IN TAIPEI. PARTICIPANTS WERE RANDOMLY ASSIGNED TO INTERVENTION (N=48) OR CONTROL (N=46) GROUPS USING CLINSTAT BLOCK RANDOMIZATION. INTERVENTION: THE 20-WEEK INTERVENTION COMPRISED TWO WEEKLY 70-MIN YOGA SESSIONS LED BY A MIDWIFE CERTIFIED AS A YOGA INSTRUCTOR; THE CONTROL GROUP RECEIVED ONLY ROUTINE PRENATAL CARE. MAIN OUTCOME MEASURES: IN BOTH GROUPS, PARTICIPANTS' SALIVARY CORTISOL AND IMMUNOGLOBULIN A LEVELS WERE COLLECTED BEFORE AND AFTER YOGA EVERY 4 WEEKS FROM 16 TO 36 WEEKS' GESTATION. RESULTS: THE INTERVENTION GROUP HAD LOWER SALIVARY CORTISOL (P<0.001) AND HIGHER IMMUNOGLOBULIN A (P<0.001) LEVELS IMMEDIATELY AFTER YOGA THAN THE CONTROL GROUP. SPECIFICALLY, THE INTERVENTION GROUP HAD SIGNIFICANTLY HIGHER LONG-TERM SALIVARY IMMUNOGLOBULIN A LEVELS THAN THE CONTROL GROUP (P=0.018), AND INFANTS BORN TO WOMEN IN THE INTERVENTION GROUP WEIGHED MORE THAN THOSE BORN TO THE CONTROL GROUP (P<0.001). CONCLUSION: PRENATAL YOGA SIGNIFICANTLY REDUCED PREGNANT WOMEN'S STRESS AND ENHANCED THEIR IMMUNE FUNCTION. CLINICIANS SHOULD LEARN THE MECHANISMS OF YOGA AND ITS EFFECTS ON PREGNANT WOMEN. OUR FINDINGS CAN GUIDE CLINICIANS TO HELP PREGNANT WOMEN ALLEVIATE THEIR STRESS AND ENHANCE THEIR IMMUNE FUNCTION.	2017	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
19 1194  37 EXAMINING MEDIATORS AND MODERATORS OF YOGA FOR WOMEN WITH BREAST CANCER UNDERGOING RADIOTHERAPY. HYPOTHESIS THIS STUDY EXAMINES MODERATORS AND MEDIATORS OF A YOGA INTERVENTION TARGETING QUALITY-OF-LIFE (QOL) OUTCOMES IN WOMEN WITH BREAST CANCER RECEIVING RADIOTHERAPY.METHODS WOMEN UNDERGOING 6 WEEKS OF RADIOTHERAPY WERE RANDOMIZED TO A YOGA (YG; N = 53) OR STRETCHING (ST; N = 56) INTERVENTION OR A WAITLIST CONTROL GROUP (WL; N = 54). DEPRESSIVE SYMPTOMS AND SLEEP DISTURBANCES WERE MEASURED AT BASELINE. MEDIATOR (POSTTRAUMATIC STRESS SYMPTOMS, BENEFIT FINDING, AND CORTISOL SLOPE) AND OUTCOME (36-ITEM SHORT FORM [SF]-36 MENTAL AND PHYSICAL COMPONENT SCALES [MCS AND PCS]) VARIABLES WERE ASSESSED AT BASELINE, END-OF-TREATMENT, AND 1-, 3-, AND 6-MONTHS POSTTREATMENT. RESULTS BASELINE DEPRESSIVE SYMPTOMS (P = .03) AND SLEEP DISTURBANCES (P < .01) MODERATED THE GROUP X TIME EFFECT ON MCS, BUT NOT PCS. WOMEN WITH HIGH BASELINE DEPRESSIVE SYMPTOMS IN YG REPORTED MARGINALLY HIGHER 3-MONTH MCS THAN THEIR COUNTERPARTS IN WL (P = .11). WOMEN WITH HIGH BASELINE SLEEP DISTURBANCES IN YG REPORTED HIGHER 3-MONTHS MCS THAN THEIR COUNTERPARTS IN WL (P < .01) AND HIGHER 6-MONTH MCS THAN THEIR COUNTERPARTS IN ST (P = .01). YG LED TO GREATER BENEFIT FINDING THAN ST AND WL ACROSS THE FOLLOW-UP (P = .01). THREE-MONTH BENEFIT FINDING PARTIALLY MEDIATED THE EFFECT OF YG ON 6-MONTH PCS. POSTTRAUMATIC STRESS SYMPTOMS AND CORTISOL SLOPE DID NOT MEDIATE TREATMENT EFFECT ON QOL. CONCLUSION YOGA MAY PROVIDE THE GREATEST MENTAL-HEALTH-RELATED QOL BENEFITS FOR THOSE EXPERIENCING PRE-RADIOTHERAPY SLEEP DISTURBANCE AND DEPRESSIVE SYMPTOMS. YOGA MAY IMPROVE PHYSICAL-HEALTH-RELATED QOL BY INCREASING ABILITY TO FIND BENEFIT IN THE CANCER EXPERIENCE.	2016	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
20 2836  46 YOGA'S IMPACT ON INFLAMMATION, MOOD, AND FATIGUE IN BREAST CANCER SURVIVORS: A RANDOMIZED CONTROLLED TRIAL. PURPOSE: TO EVALUATE YOGA'S IMPACT ON INFLAMMATION, MOOD, AND FATIGUE. PATIENTS AND METHODS: A RANDOMIZED CONTROLLED 3-MONTH TRIAL WAS CONDUCTED WITH TWO POST-TREATMENT ASSESSMENTS OF 200 BREAST CANCER SURVIVORS ASSIGNED TO EITHER 12 WEEKS OF 90-MINUTE TWICE PER WEEK HATHA YOGA CLASSES OR A WAIT-LIST CONTROL. THE MAIN OUTCOME MEASURES WERE LIPOPOLYSACCHARIDE-STIMULATED PRODUCTION OF PROINFLAMMATORY CYTOKINES INTERLEUKIN-6 (IL-6), TUMOR NECROSIS FACTOR ALPHA (TNF-ALPHA), AND INTERLEUKIN-1BETA (IL-1BETA), AND SCORES ON THE MULTIDIMENSIONAL FATIGUE SYMPTOM INVENTORY-SHORT FORM (MFSI-SF), THE VITALITY SCALE FROM THE MEDICAL OUTCOMES STUDY 36-ITEM SHORT FORM (SF-36), AND THE CENTER FOR EPIDEMIOLOGICAL STUDIES-DEPRESSION (CES-D) SCALE. RESULTS: IMMEDIATELY POST-TREATMENT, FATIGUE WAS NOT LOWER (P > .05) BUT VITALITY WAS HIGHER (P = .01) IN THE YOGA GROUP COMPARED WITH THE CONTROL GROUP. AT 3 MONTHS POST-TREATMENT, FATIGUE WAS LOWER IN THE YOGA GROUP (P = .002), VITALITY WAS HIGHER (P = .01), AND IL-6 (P = .027), TNF-ALPHA (P = .027), AND IL-1BETA (P = .037) WERE LOWER FOR YOGA PARTICIPANTS COMPARED WITH THE CONTROL GROUP. GROUPS DID NOT DIFFER ON DEPRESSION AT EITHER TIME (P > .2). PLANNED SECONDARY ANALYSES SHOWED THAT THE FREQUENCY OF YOGA PRACTICE HAD STRONGER ASSOCIATIONS WITH FATIGUE AT BOTH POST-TREATMENT VISITS (P = .019; P < .001), AS WELL AS VITALITY (P = .016; P = .0045), BUT NOT DEPRESSION (P > .05) THAN SIMPLE GROUP ASSIGNMENT; MORE FREQUENT PRACTICE PRODUCED LARGER CHANGES. AT 3 MONTHS POST-TREATMENT, INCREASING YOGA PRACTICE ALSO LED TO A DECREASE IN IL-6 (P = .01) AND IL-1BETA (P = .03) PRODUCTION BUT NOT IN TNF-ALPHA PRODUCTION (P > .05). CONCLUSION: CHRONIC INFLAMMATION MAY FUEL DECLINES IN PHYSICAL FUNCTION LEADING TO FRAILTY AND DISABILITY. IF YOGA DAMPENS OR LIMITS BOTH FATIGUE AND INFLAMMATION, THEN REGULAR PRACTICE COULD HAVE SUBSTANTIAL HEALTH BENEFITS.	2014