1  770 159 EFFECT OF UNINOSTRIL YOGA BREATHING ON BRAIN HEMODYNAMICS: A FUNCTIONAL NEAR-INFRARED SPECTROSCOPY STUDY. OBJECTIVES: TO MEASURE THE EFFECT OF THE RIGHT AND LEFT NOSTRIL YOGA BREATHING ON FRONTAL HEMODYNAMIC RESPONSES IN 32 RIGHT HANDED HEALTHY MALE SUBJECTS WITHIN THE AGE RANGE OF 18-35 YEARS (23.75 +/- 4.14 YEARS). MATERIALS AND METHODS: EACH SUBJECT PRACTICED RIGHT NOSTRIL YOGA BREATHING (RNYB), LEFT NOSTRIL YOGA BREATHING (LNYB) OR BREATH AWARENESS (BA) (AS CONTROL) FOR 10 MIN AT THE SAME TIME OF THE DAY FOR THREE CONSECUTIVE DAYS, RESPECTIVELY. THE SEQUENCE OF INTERVENTION WAS ASSIGNED RANDOMLY. THE FRONTAL HEMODYNAMIC RESPONSE IN TERMS OF CHANGES IN THE OXYGENATED HEMOGLOBIN (OXYHB), DEOXYGENATED HEMOGLOBIN (DEOXYHB), AND TOTAL HEMOGLOBIN (TOTALHB OR BLOOD VOLUME) CONCENTRATION WAS TAPPED FOR 5 MIN BEFORE (PRE) AND 10 MIN DURING THE BREATHING PRACTICES USING A 16 CHANNEL FUNCTIONAL NEAR-INFRARED SYSTEM (FNIR100-ACK-W, BIOPAC SYSTEMS, INC., U.S.A.). AVERAGE OF THE EIGHT CHANNELS ON EACH SIDE (RIGHT AND LEFT FRONTALS) WAS OBTAINED FOR THE TWO SESSIONS (PRE AND DURING). DATA WAS ANALYZED USING SPSS VERSION 10.0 THROUGH PAIRED AND INDEPENDENT SAMPLES T-TEST. RESULTS: WITHIN GROUP COMPARISON SHOWED THAT DURING RNYB, OXYHB LEVELS INCREASED SIGNIFICANTLY IN THE LEFT PREFRONTAL CORTEX (PFC) AS COMPARED TO THE BASELINE (P = 0.026). LNYB SHOWED A TREND TOWARDS SIGNIFICANCE FOR REDUCTION IN OXYHB IN THE RIGHT HEMISPHERE (P = 0.057). WHEREAS BA CAUSED SIGNIFICANT REDUCTION IN DEOXYHB (P = 0.023) IN THE LEFT HEMISPHERE. BETWEEN GROUPS COMPARISON REVEALED THAT OXYHB AND BLOOD VOLUME IN THE LEFT PFC INCREASED SIGNIFICANTLY DURING RNYB AS COMPARED TO BA (OXYHB: P =0.012; TOTALHB: P =0.017) AND LNYB (OXYHB: P =0.024; TOTALHB: P =0.034). CONCLUSION: RNYB INCREASED OXYGENATION AND BLOOD VOLUME IN THE LEFT PFC AS COMPARED TO BA AND LNYB. THIS SUPPORTS THE RELATIONSHIP BETWEEN NASAL CYCLE AND ULTRADIAN RHYTHM OF CEREBRAL DOMINANCE AND SUGGESTS A POSSIBLE APPLICATION OF UNINOSTRIL YOGA BREATHING IN THE MANAGEMENT OF PSYCHOPATHOLOGICAL STATES WHICH SHOW LATERALIZED CEREBRAL DYSFUNCTIONS.	2016	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
2 2652  30 YOGA IMPROVES MITOCHONDRIAL HEALTH AND REDUCES SEVERITY OF AUTOIMMUNE INFLAMMATORY ARTHRITIS: A RANDOMIZED CONTROLLED TRIAL. BACKGROUND: OXIDATIVE STRESS (OS) AND MITOCHONDRIAL ALTERATIONS HAVE BEEN IMPLICATED IN THE PATHOGENESIS OF RHEUMATOID ARTHRITIS (RA). VARIOUS ENVIRONMENTAL TRIGGERS LIKE AIR POLLUTANTS, SMOKING, UNHEALTHY SOCIAL HABITS AND SEDENTARY LIFESTYLE INDUCE OS, WHICH MAY COMPROMISE MITOCHONDRIAL INTEGRITY. THIS TRIAL WAS DESIGNED TO EXPLORE THE EFFECT OF 8-WEEKS YOGA PRACTICE ON MITOCHONDRIAL HEALTH AND DISEASE SEVERITY IN AN ACTIVE RA GROUP COMPARED WITH A USUAL-CARE CONTROL GROUP. METHODS: A TOTAL OF 70 SUBJECTS WERE RANDOMIZED INTO TWO GROUPS: YOGA GROUP AND NON-YOGA GROUP. MITOCHONDRIAL HEALTH WAS ASSESSED BY CALCULATION OF MITOCHONDRIAL DNA COPY NUMBER (MTDNA-CN), OS MARKERS, MITOCHONDRIAL ACTIVITY, MITOCHONDRIAL MEMBRANE POTENTIAL (DELTAPSIM), CIRCADIAN RHYTHM MARKERS AND TRANSCRIPTS ASSOCIATED WITH MITOCHONDRIAL INTEGRITY: AMPK, TIMP-1, KLOTHO, SIRT-1, AND TFAM. PARAMETERS OF DISEASE ACTIVITY AND DISABILITY QUOTIENT WERE ALSO ASSESSED BY DISEASE ACTIVITY SCORE - ERYTHROCYTE SEDIMENTATION RATE (DAS28-ESR) AND HEALTH ASSESSMENT QUESTIONNAIRE-DISABILITY INDEX (HAQ-DI), RESPECTIVELY. RESULTS: IN YOGA GROUP, THERE WAS A SIGNIFICANT UPREGULATION OF MTDNA-CN, MITOCHONDRIAL ACTIVITY MARKERS, DELTAPSIM, AND TRANSCRIPTS THAT MAINTAIN MITOCHONDRIAL INTEGRITY AFTER 8-WEEKS OF YOGA. THERE WAS OPTIMIZATION OF OS MARKERS, AND CIRCADIAN RHYTHM MARKERS POST 8-WEEKS PRACTICE OF YOGA. YOGA GROUP PARTICIPANTS SHOWED SIGNIFICANT IMPROVEMENTS IN DAS28-ESR (P < 0.05) AND HAQ-DI (P < 0.05) OVER THE NON-YOGA GROUP. CONCLUSION: ADOPTION OF YOGA BY RA PATIENTS HOLDS THE KEY TO ENHANCE MITOCHONDRIAL HEALTH, IMPROVE CIRCADIAN RHYTHM MARKERS, OS MARKER REGULATION, UPREGULATION OF TRANSCRIPTS THAT MAINTAIN MITOCHONDRIAL INTEGRITY, REDUCE DISEASE ACTIVITY AND ITS ASSOCIATED CONSEQUENCES ON HEALTH OUTCOME AND HENCE CAN BE BENEFICIAL AS AN ADJUNCT THERAPY.	2021	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
3 1329  45 HIGH-FREQUENCY CEREBRAL ACTIVATION AND INTERHEMISPHERIC SYNCHRONIZATION FOLLOWING SUDARSHAN KRIYA YOGA AS GLOBAL BRAIN RHYTHMS: THE STATE EFFECTS. CONTEXT: RESPIRATION IS KNOWN TO MODULATE NEURONAL OSCILLATIONS IN THE BRAIN AND IS MEASURED BY ELECTROENCEPHALOGRAM (EEG). SUDARSHAN KRIYA YOGA (SKY) IS A POPULAR BREATHING PROCESS AND IS ESTABLISHED FOR ITS SIGNIFICANT EFFECTS ON THE VARIOUS ASPECTS OF PHYSIOLOGY AND PSYCHOLOGY. AIMS: THIS STUDY AIMED TO OBSERVE NEURONAL OSCILLATIONS IN MULTIFREQUENCY BANDS AND INTERHEMISPHERIC SYNCHRONIZATION FOLLOWING SKY. SETTINGS AND DESIGN: THIS STUDY EMPLOYED BEFORE- AND AFTER-STUDY DESIGN. SUBJECTS AND METHODS: FORTY HEALTHY VOLUNTEERS (AVERAGE AGE 25.45 +/- 5.75, 23 MALES AND 17 FEMALES) PARTICIPATED IN THE STUDY. NINETEEN-CHANNEL EEG WAS RECORDED AND ANALYZED FOR 5 MIN EACH: BEFORE AND AFTER SKY. SPECTRAL POWER FOR DELTA, THETA, ALPHA, BETA, AND GAMMA FREQUENCY BAND WAS CALCULATED USING MULTI-TAPER FAST FOURIER TRANSFORM (CHRONUX TOOLBOX). THE ASYMMETRY INDEX WAS CALCULATED BY SUBTRACTING THE NATURAL LOG OF POWERS OF LEFT (L) HEMISPHERE FROM THE RIGHT((R)) TO SHOW INTERHEMISPHERIC SYNCHRONIZATION. STATISTICAL ANALYSIS: PAIRED T-TEST WAS USED FOR STATISTICAL ANALYSIS. RESULTS: SPECTRAL POWER INCREASED SIGNIFICANTLY IN ALL FREQUENCY BANDS BILATERALLY IN FRONTAL, CENTRAL, PARIETAL, TEMPORAL, AND OCCIPITAL REGIONS OF THE BRAIN AFTER LONG SKY. ELECTRICAL ACTIVITY SHIFTED FROM LOWER TO HIGHER FREQUENCY RANGE WITH A SIGNIFICANT RISE IN THE GAMMA AND BETA POWERS FOLLOWING SKY. ASYMMETRY INDEX VALUES TENDED TOWARD 0 FOLLOWING SKY. CONCLUSIONS: A SINGLE SESSION OF SKY GENERATES GLOBAL BRAIN RHYTHM DOMINANTLY WITH HIGH-FREQUENCY CEREBRAL ACTIVATION AND INITIATES APPROPRIATE INTERHEMISPHERIC SYNCHRONIZATION IN BRAIN RHYTHMS AS STATE EFFECTS. THIS SUGGESTS THAT SKY LEADS TO BETTER ATTENTION, MEMORY, AND EMOTIONAL AND AUTONOMIC CONTROL ALONG WITH ENHANCED COGNITIVE FUNCTIONS, WHICH FINALLY IMPROVES PHYSICAL AND MENTAL WELL-BEING.	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
4 1649  28 MULTI-OMICS INTEGRATION AND INTERACTOMICS REVEALS MOLECULAR NETWORKS AND REGULATORS OF THE BENEFICIAL EFFECT OF YOGA AND EXERCISE. BACKGROUND: YOGA IS A MULTIFACETED SPIRITUAL TOOL THAT HELPS IN MAINTAINING HEALTH, PEACE OF MIND, AND POSITIVE THOUGHTS. IN THE CONTEXT OF ASANA, YOGA IS SIMILAR TO PHYSICAL EXERCISE. THIS STUDY AIMS TO CONSTRUCT A MOLECULAR NETWORK TO FIND HUB GENES THAT PLAY IMPORTANT ROLES IN PHYSICAL EXERCISE AND YOGA. METHODOLOGY: WE COMBINED DIFFERENTIALLY EXPRESSED GENES (DEGS) IN YOGA AND EXERCISE USING COMPUTATIONAL BIOINFORMATICS FROM PUBLICLY AVAILABLE GENE EXPRESSION OMNIBUS (GEO) DATASETS AND IDENTIFIED THE CODIFFERENTIALLY EXPRESSED MRNAS WITH GEO2R. THE CO-DEGS WERE DIVIDED INTO FOUR DIFFERENT GROUPS AND EACH GROUP WAS SUBJECTED TO PROTEIN-PROTEIN INTERACTION (PPI) NETWORK, PATHWAYS ANALYSIS, AND GENE ONTOLOGY. RESULTS: OUR STUDY IDENTIFIED IMMUNOLOGICAL MODULATION AS A DOMINANT TARGET OF DIFFERENTIAL EXPRESSION IN YOGA AND EXERCISE. YOGA PREDOMINANTLY MODULATED GENES AFFECTING THE TH1 AND NK CELLS, WHEREAS CYTOKINES, MACROPHAGE ACTIVATION, AND OXIDATIVE STRESS WERE AFFECTED BY EXERCISE. WE ALSO OBSERVED THAT WHILE YOGA REGULATED GENES FOR TWO MAIN PHYSIOLOGICAL FUNCTIONS OF THE BODY, NAMELY CIRCADIAN RHYTHM (BHLHE40) AND IMMUNITY (LBP, T-BOX TRANSCRIPTION FACTOR 21, CEACAM1), EXERCISE-REGULATED GENES INVOLVED IN APOPTOSIS (BAG3, PROTEIN KINASE C ALPHA), ANGIOGENESIS, AND CELLULAR ADHESION (EPH RECEPTOR A1). CONCLUSION: THE DISSIMILARITY IN THE GENETIC EXPRESSION PATTERNS IN YOGA AND EXERCISE HIGHLIGHTS THE DISCRETE EFFECT OF EACH IN BIOLOGICAL SYSTEMS. THE INTEGRATION AND CONVERGENCES OF MULTI-OMICS SIGNALS CAN PROVIDE DEEPER AND COMPREHENSIVE INSIGHTS INTO THE VARIOUS BIOLOGICAL MECHANISMS THROUGH WHICH YOGA AND EXERCISE EXERT THEIR BENEFICIAL EFFECTS AND OPENS UP POTENTIAL NEWER RESEARCH AREAS.	2022	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
5  650  33 DYNAMICS OF HEART RATE VARIABILITY UNDER THE INFLUENCE OF COURSE YOGA BREATHING EXERCISES ON HEALTHY YOUNG PEOPLE. OBJECTIVE: INTRODUCTION: HEART RATE VARIABILITY IS A HIGHLY INFORMATIVE NON-INVASIVE METHOD OF RESEARCH NOT ONLY FOR THE FUNCTIONAL STATE OF THE CARDIOVASCULAR SYSTEM AND ALSO FOR THE INTEGRATIVE REGULATORY ACTIVITY OF THE AUTONOMIC NERVOUS SYSTEM. THE POSITIVE EFFECT OF DIAPHRAGMATIC BREATHING IS POSITIVE IN THE MODE OF BIOLOGICAL FEEDBACK USING PORTABLE DEVICES, BUT THERE IS LITTLE EVIDENCE OF THE USE OF YOGA BREATHING GYMNASTICS IN ORDER TO INFLUENCE THE HEART RATE VARIABILITY. THE AIM: TO COMPARE THE POSSIBILITIES OF USING COURSES OF BREATHING GYMNASTICS OF YOGIS AND DIAPHRAGMATIC BREATHING SESSIONS IN THE MODE OF BIOLOGICAL FEEDBACK USING A PORTABLE DEVICE. PATIENTS AND METHODS: MATERIALS AND METHODS: THE STUDY INVOLVED 70 PRACTICALLY HEALTHY FOREIGNERS, WHO WERE DIVIDED INTO 2 GROUPS OF 35 PEOPLE. PARTICIPANTS OF THE 1ST GROUP DAILY ENGAGE IN RESPIRATORY EXERCISES PRANAYAMA FOR 15 MINUTES IN 1 MONTH. PARTICIPANTS IN THE 2ND GROUP USED THE MYCALMBEAT PORTABLE DEVICE. HEART RATE VARIABILITY WAS REGISTERED BY USING THE COMPUTER DIAGNOSTIC COMPLEX "CARDIOLAB" ("KHAI-MEDIKA", UKRAINE). RESULTS: RESULTS: IN BOTH GROUPS THERE WAS SIMILAR DYNAMICS OF HEART RATE VARIABILITY INDICES, BUT ITS SEVERITY WAS DIFFERENT. THE COMMON INTEGRAL EFFECT WAS A SIGNIFICANT GROWTH OF HEART RATE VARIABILITY BOTH ACCORDING TO STATISTICAL AND SPECTRAL INDICATORS - TOTAL POWER INCREASED, AS WELL AS HIGH-FREQUENCY COMPONENT. THE POWER OF THE VERY-LOW FREQUENCY WAVES HAS PROBABLY DECREASED ONLY IN THE GROUP WITH THE DEVICE. IN THE PERCENTAGE STRUCTURE OF THE CARDIAC RHYTHM SPECTRUM, THE SPECIFIC WEIGHT OF VERY-LOW FREQUENCY COMPONENT AND THE PERCENTAGE OF HIGH-FREQUENCY COMPONENT INCREASED. CONCLUSION: CONCLUSIONS: RESPIRATORY GYMNASTICS YOGA FOR 15 MINUTES DAILY CONTRIBUTES TO THE GROWTH OF HEART RATE VARIABILITY THROUGH THE SUPPRESSION OF THE CENTRAL LINK (VERY-LOW FREQUENCY COMPONENT) OF REGULATION OF CARDIAC RHYTHM AND INCREASED ACTIVITY OF PARASYMPATHETIC INFLUENCES (HIGH-FREQUENCY COMPONENT), AS WELL AS THE REDISTRIBUTION OF REGULATORY ACTIVITY OF THE CENTRAL NERVOUS SYSTEM BETWEEN THE CENTRAL AND PERIPHERAL LINKS OF REGULATION OF THE CARDIAC RHYTHM IN FAVOR OF THE LATTER.	2019	
                                                                                                                                                                                                                                                                                                                                  
6 1273  82 FRONTAL HEMODYNAMIC RESPONSES TO HIGH FREQUENCY YOGA BREATHING IN SCHIZOPHRENIA: A FUNCTIONAL NEAR-INFRARED SPECTROSCOPY STUDY. FRONTAL HEMODYNAMIC RESPONSES TO HIGH FREQUENCY YOGA BREATHING TECHNIQUE, KAPALABHATI (KB), WERE COMPARED BETWEEN PATIENTS OF SCHIZOPHRENIA (N = 18; 14 MALES, 4 FEMALES) AND AGE, GENDER, AND EDUCATION MATCHED HEALTHY SUBJECTS (N = 18; 14 MALES, 4 FEMALES) USING FUNCTIONAL NEAR-INFRARED SPECTROSCOPY. THE DIAGNOSIS WAS CONFIRMED BY A PSYCHIATRIST USING DSM-IV. ALL PATIENTS EXCEPT ONE RECEIVED ATYPICAL ANTIPSYCHOTICS (ONE WAS ON TYPICAL). THEY HAD OBTAINED A STABILIZED STATE AS EVIDENCED BY A STEADY UNCHANGED MEDICATION FROM THEIR PSYCHIATRIST FOR THE PAST 3 MONTHS OR LONGER. THEY LEARNED KB, AMONG OTHER YOGA PROCEDURES, IN A YOGA RETREAT. KB WAS PRACTICED AT THE RATE OF 120 TIMES/MIN FOR 1 MIN. HEALTHY SUBJECTS WHO WERE FRESHLY LEARNING YOGA TOO WERE TAUGHT KB. BOTH THE GROUPS HAD NO PREVIOUS EXPOSURE TO KB PRACTICE AND THE TRAINING WAS CARRIED OUT OVER 2 WEEKS. A CHEST PRESSURE TRANSDUCER WAS USED TO MONITOR THE FREQUENCY AND INTENSITY OF THE PRACTICE OBJECTIVELY. THE FRONTAL HEMODYNAMIC RESPONSE IN TERMS OF THE OXYGENATED HEMOGLOBIN (OXYHB), DEOXYGENATED HEMOGLOBIN (DEOXYHB), AND TOTAL HEMOGLOBIN (TOTALHB) OR BLOOD VOLUME CONCENTRATION WAS TAPPED FOR 5 MIN BEFORE, 1 MIN DURING, AND FOR 5 MIN AFTER KB. THIS WAS OBTAINED IN A QUIET ROOM USING A 16-CHANNEL FUNCTIONAL NEAR-INFRARED SYSTEM (FNIR100-ACK-W, BIOPAC SYSTEMS, INC., USA). THE AVERAGE OF THE EIGHT CHANNELS FOR EACH SIDE (RIGHT AND LEFT FRONTALS) WAS OBTAINED FOR THE THREE SESSIONS. THE CHANGES IN THE LEVELS OF OXYHB, DEOXYHB, AND BLOOD VOLUME FOR THE THREE SESSIONS WERE COMPARED BETWEEN THE TWO GROUPS USING INDEPENDENT SAMPLES T-TEST. WITHIN GROUP COMPARISON SHOWED THAT THE INCREASE IN BILATERAL OXYHB AND TOTALHB FROM THE BASELINE WAS HIGHLY SIGNIFICANT IN HEALTHY CONTROLS DURING KB (RIGHT OXYHB, P = 0.00; LEFT OXYHB, P = 0.00 AND RIGHT TOTALHB, P = 0.01; LEFT TOTALHB, P = 0.00), WHEREAS SCHIZOPHRENIA PATIENTS DID NOT SHOW ANY SIGNIFICANT CHANGES IN THE SAME ON BOTH THE SIDES. ON THE OTHER HAND, SCHIZOPHRENIA PATIENTS SHOWED SIGNIFICANT REDUCTION IN DEOXYHB IN THE RIGHT PRE-FRONTAL CORTEX (RIGHT DEOXYHB, P = 0.00). COMPARISON BETWEEN THE GROUPS SHOWED THAT SCHIZOPHRENIA PATIENTS HAVE REDUCED BILATERAL PRE-FRONTAL ACTIVATION (RIGHT OXYHB, P = 0.01; LEFT OXYHB, P = 0.03 AND RIGHT TOTAL HB, P = 0.03; LEFT TOTAL HB, P = 0.04) DURING KB AS COMPARED TO HEALTHY CONTROLS. THIS HYPO-FRONTALITY OF SCHIZOPHRENIA PATIENTS IN RESPONSE TO KB MAY BE USED CLINICALLY TO SUPPORT THE DIAGNOSIS OF SCHIZOPHRENIA IN FUTURE.	2014	

7  350  38 ASSESSMENT OF CARDIAC AUTONOMIC TONE FOLLOWING LONG SUDARSHAN KRIYA YOGA IN ART OF LIVING PRACTITIONERS. OBJECTIVE: THE BREATHING PROCESSES ARE KNOWN TO MODULATE CARDIAC AUTONOMIC TONE AND IMPROVE PSYCHOLOGICAL STATUS. WE INVESTIGATED CARDIAC AUTONOMIC TONE FOLLOWING LONG SUDARSHAN KRIYA YOGA (SKY) USING HEART RATE VARIABILITY (HRV) AND SKIN CONDUCTANCE LEVEL (SCL). METHODS: THIRTY HEALTHY VOLUNTEERS (AGE 28.3 +/- 8.4 YEARS; 23 M: 7 F) PARTICIPATED IN THE STUDY. ELECTROCARDIOGRAM (ECG) AND SCL WERE RECORDED FOR 5 MIN EACH, BEFORE AND AFTER LONG SKY. LONG SKY IS A COMBINATION OF PRANAYAMA AND CYCLIC RHYTHMIC BREATHING AND IS PERFORMED BY FOLLOWING THE GUIDED AUDIO INSTRUCTIONS. HRV ANALYSIS WAS USED FOR THE ASSESSMENT OF CARDIAC AUTONOMIC TONE. TIME AND FREQUENCY DOMAIN PARAMETERS OF HRV WERE CALCULATED BY USING RR INTERVAL OF ECG. SCL WAS ACQUIRED USING GALVANIC SKIN RESPONSE (GSR) AMPLIFIER OF POWERLAB IN MICROSEIMENS (MUS). RESULTS: TIME DOMAIN PARAMETERS OF HRV, INCLUDING MEAN RR INTERVAL (P = 0.000), RESPIRATORY SINUS ARRHYTHMIA (RSA) (P = 0.037), STANDARD DEVIATION OF ALL NN INTERVALS (SDNN) (P = 0.013), NN50 COUNT DIVIDED BY THE TOTAL NUMBER OF ALL NN INTERVALS (PNN50) (P = 0.004), AND SQUARE ROOT OF THE MEAN OF THE SUM OF THE SQUARES OF DIFFERENCES BETWEEN ADJACENT NN INTERVALS (RMSSD) (P = 0.002) INCREASED, AND MEAN HEART RATE DECREASED (P = 0.000) FOLLOWING LONG SKY. IN FREQUENCY DOMAIN ANALYSIS, POWER OF LOW-FREQUENCY (LF) COMPONENT (P = 0.010) AND LF/HF RATIO (P = 0.008) DECREASED SIGNIFICANTLY, WHEREAS POWER OF HIGH FREQUENCY (HF) SIGNIFICANTLY INCREASED (P = 0.010). SCL DECREASED FOLLOWING LONG SKY, ALTHOUGH IT DID NOT ATTAIN STATISTICAL SIGNIFICANCE. CONCLUSIONS: THE RESULTS SUGGEST THAT LONG SKY INDUCES SIGNIFICANT OSCILLATIONS IN CARDIAC AUTONOMIC TONE. PARASYMPATHETIC ACTIVITY INCREASES AND SYMPATHETIC ACTIVITY DECREASES AND SYMPATHOVAGAL BALANCE IMPROVES FOLLOWING LONG SKY. DECREASE IN SYMPATHETIC ACTIVITY IS ALSO DEMONSTRATED BY DECREASE IN CONDUCTANCE ALTHOUGH IT DID NOT REACH STATISTICAL SIGNIFICANCE. FROM THIS STUDY IT CAN BE CONCLUDED THAT LONG SKY HAS A BENEFICIAL EFFECT ON CARDIAC AUTONOMIC TONE, AND PSYCHOPHYSIOLOGICAL RELAXATION. IT MAY SERVE AS A TOOL TO IMPROVE HRV, WHICH IS THE MARKER OF CARDIOVASCULAR HEALTH.	2017	
                                                                                                                                                                                                                                                                                                                                                              
8  744  29 EFFECT OF ROSARY PRAYER AND YOGA MANTRAS ON AUTONOMIC CARDIOVASCULAR RHYTHMS: COMPARATIVE STUDY. OBJECTIVE: TO TEST WHETHER RHYTHMIC FORMULAS SUCH AS THE ROSARY AND YOGA MANTRAS CAN SYNCHRONISE AND REINFORCE INHERENT CARDIOVASCULAR RHYTHMS AND MODIFY BAROREFLEX SENSITIVITY. DESIGN: COMPARISON OF EFFECTS OF RECITATION OF THE AVE MARIA (IN LATIN) OR OF A MANTRA, DURING SPONTANEOUS AND METRONOME CONTROLLED BREATHING, ON BREATHING RATE AND ON SPONTANEOUS OSCILLATIONS IN RR INTERVAL, AND ON BLOOD PRESSURE AND CEREBRAL CIRCULATION. SETTING: FLORENCE AND PAVIA, ITALY. PARTICIPANTS: 23 HEALTHY ADULTS. MAIN OUTCOME MEASURES: BREATHING RATE, REGULARITY OF BREATHING, BAROREFLEX SENSITIVITY, FREQUENCY OF CARDIOVASCULAR OSCILLATIONS. RESULTS: BOTH PRAYER AND MANTRA CAUSED STRIKING, POWERFUL, AND SYNCHRONOUS INCREASES IN EXISTING CARDIOVASCULAR RHYTHMS WHEN RECITED SIX TIMES A MINUTE. BAROREFLEX SENSITIVITY ALSO INCREASED SIGNIFICANTLY, FROM 9.5 (SD 4.6) TO 11.5 (4.9) MS/MM HG, P<0.05. CONCLUSION: RHYTHM FORMULAS THAT INVOLVE BREATHING AT SIX BREATHS PER MINUTE INDUCE FAVOURABLE PSYCHOLOGICAL AND POSSIBLY PHYSIOLOGICAL EFFECTS.	2001	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
9 1208  39 EXPLORATION OF LOWER FREQUENCY EEG DYNAMICS AND CORTICAL ALPHA ASYMMETRY IN LONG-TERM RAJYOGA MEDITATORS. BACKGROUND: RAJYOGA MEDITATION IS TAUGHT BY PRAJAPITA BRAHMAKUMARIS WORLD SPIRITUAL UNIVERSITY (BRAHMAKUMARIS) AND HAS BEEN FOLLOWED BY MORE THAN ONE MILLION FOLLOWERS ACROSS THE GLOBE. HOWEVER, RARE STUDIES WERE CONDUCTED ON PHYSIOLOGICAL ASPECTS OF RAJYOGA MEDITATION USING ELECTROENCEPHALOGRAPHY (EEG). BAND POWER AND CORTICAL ASYMMETRY WERE NOT STUDIED WITH RAJYOGA MEDITATORS. AIMS: THIS STUDY AIMS TO INVESTIGATE THE EFFECT OF REGULAR MEDITATION PRACTICE ON EEG BRAIN DYNAMICS IN LOW-FREQUENCY BANDS OF LONG-TERM RAJYOGA MEDITATORS. SETTINGS AND DESIGN: SUBJECTS WERE MATCHED FOR AGE IN BOTH GROUPS. LOWER FREQUENCY EEG BANDS WERE ANALYZED IN RESTING AND DURING MEDITATION. MATERIALS AND METHODS: TWENTY-ONE MALE LONG-TERM MEDITATORS (LTMS) AND SAME NUMBER OF CONTROLS WERE SELECTED TO PARTICIPATE IN STUDY AS PAR INCLUSION CRITERIA. SEMI HIGH-DENSITY EEG WAS RECORDED BEFORE AND DURING MEDITATION IN LTM GROUP AND RESTING IN CONTROL GROUP. THE MAIN OUTCOME OF THE STUDY WAS SPECTRAL POWER OF ALPHA AND THETA BANDS AND CORTICAL (HEMISPHERICAL) ASYMMETRY CALCULATED USING BAND POWER. STATISTICAL ANALYSIS: ONE-WAY ANOVA WAS PERFORMED TO FIND THE SIGNIFICANT DIFFERENCE BETWEEN EEG SPECTRAL PROPERTIES OF GROUPS. PEARSON'S CHI-SQUARE TEST WAS USED TO FIND DIFFERENCE AMONG DEMOGRAPHICS DATA. RESULTS: RESULTS REVEAL HIGH-BAND POWER IN ALPHA AND THETA SPECTRA IN MEDITATORS. CORTICAL ASYMMETRY CALCULATED THROUGH EEG POWER WAS ALSO FOUND TO BE HIGH IN FRONTAL AS WELL AS PARIETAL CHANNELS. HOWEVER, NO CORRELATION WAS SEEN BETWEEN THE EXPERIENCE OF MEDITATION (YEARS, HOURS) PRACTICE AND EEG INDICES. CONCLUSION: OVERALL FINDINGS INDICATE CONTRIBUTION OF SMALLER FREQUENCIES (ALPHA AND THETA) WHILE MAINTAINING MEDITATIVE EXPERIENCE. THIS SUGGESTS A POSITIVE IMPACT OF MEDITATION ON FRONTAL AND PARIETAL AREAS OF BRAIN, INVOLVED IN THE PROCESSES OF REGULATION OF SELECTIVE AND SUSTAINED ATTENTION AS WELL AS PROVIDE EVIDENCE ABOUT THEIR INVOLVEMENT IN EMOTION AND COGNITIVE PROCESSING.	2018	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
10 2228  16 THE IMPACT OF YOGA ON ATRIAL FIBRILLATION: A REVIEW OF THE YOGA MY HEART STUDY. ATRIAL FIBRILLATION IS A COMMON ARRHYTHMIA AFFECTING THOUSANDS OF INDIVIDUALS WORLDWIDE. IT IS A CONDUCTION DISORDER THAT CAUSES THE HEART TO BEAT IRREGULARLY AND RAPIDLY. THERE ARE A FEW MEDICAL APPROACHES TO MANAGE THIS COSTLY HEALTH CARE BURDEN: ANTIARRHYTHMICS TO MAINTAIN NORMAL SINUS RHYTHM, BETA BLOCKERS TO ACHIEVE RATE CONTROL WHILE ALLOWING ATRIAL FIBRILLATION TO PERSIST, AND ELECTRO-PHYSIOLOGIC INTERVENTION FOR RATE AND RHYTHM CONTROL. THESE TREATMENTS CAN BE COSTLY AND ARE NOT WITHOUT SIDE EFFECTS. YOGA, AN INTERVENTION THAT IS AVAILABLE TO PEOPLE WORLDWIDE, HAS SHOWN SOME PROMISE IN COMBATING THIS WIDESPREAD HEART DISORDER.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
11 1321  34 HEMISPHERE SPECIFIC EEG RELATED TO ALTERNATE NOSTRIL YOGA BREATHING. BACKGROUND: PREVIOUSLY, FORCED UNILATERAL NOSTRIL BREATHING WAS ASSOCIATED WITH IPSILATERAL, OR CONTRALATERAL CEREBRAL HEMISPHERE CHANGES, OR NO CHANGE. HENCE IT WAS INCONCLUSIVE. THE PRESENT STUDY WAS CONDUCTED ON 13 NORMAL HEALTHY PARTICIPANTS TO DETERMINE THE EFFECTS OF ALTERNATE NOSTRIL YOGA BREATHING ON (A) CEREBRAL HEMISPHERE ASYMMETRY, AND (B) CHANGES IN THE STANDARD EEG BANDS. METHODS: PARTICIPANTS WERE RANDOMLY ALLOCATED TO THREE SESSIONS (A) ALTERNATE NOSTRIL YOGA BREATHING (ANYB), (B) BREATH AWARENESS AND (C) QUIET SITTING, ON SEPARATE DAYS. EEG WAS RECORDED FROM BILATERALLY SYMMETRICAL SITES (FP1, FP2, C3, C4, O1 AND O2). ALL SITES WERE REFERENCED TO THE IPSILATERAL EAR LOBE. RESULTS: THERE WAS NO CHANGE IN CEREBRAL HEMISPHERE SYMMETRY. THE RELATIVE POWER IN THE THETA BAND WAS DECREASED DURING ALTERNATE NOSTRIL YOGA BREATHING (ANYB) AND THE BETA AMPLITUDE WAS LOWER AFTER ANYB. DURING QUIET SITTING THE RELATIVE POWER IN THE BETA BAND INCREASED, WHILE THE AMPLITUDE OF THE ALPHA BAND REDUCED. CONCLUSION: THE RESULTS SUGGEST THAT ANYB WAS ASSOCIATED WITH GREATER CALMNESS, WHEREAS QUIET SITTING WITHOUT SPECIFIC DIRECTIONS WAS ASSOCIATED WITH AROUSAL. THE RESULTS IMPLY A POSSIBLE USE OF ANYB FOR STRESS AND ANXIETY REDUCTION.	2017	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
12  492  37 COGNITIVE BEHAVIOR EVALUATION BASED ON PHYSIOLOGICAL PARAMETERS AMONG YOUNG HEALTHY SUBJECTS WITH YOGA AS INTERVENTION. OBJECTIVE: TO INVESTIGATE THE EFFECT OF YOGA PRACTICE ON COGNITIVE SKILLS, AUTONOMIC NERVOUS SYSTEM, AND HEART RATE VARIABILITY BY ANALYZING PHYSIOLOGICAL PARAMETERS. METHODS: THE STUDY WAS CONDUCTED ON 30 NORMAL YOUNG HEALTHY ENGINEERING STUDENTS. THEY WERE RANDOMLY SELECTED INTO TWO GROUPS: YOGA GROUP AND CONTROL GROUP. THE YOGA GROUP PRACTICED YOGA ONE AND HALF HOUR PER DAY FOR SIX DAYS IN A WEEK, FOR A PERIOD OF FIVE MONTHS. RESULTS: THE YOGA PRACTISING GROUP SHOWED INCREASED ALPHA, BETA, AND DELTA EEG BAND POWERS AND SIGNIFICANT REDUCTION IN THETA AND GAMMA BAND POWERS. THE INCREASED ALPHA AND BETA POWER CAN REPRESENT ENHANCED COGNITIVE FUNCTIONS SUCH AS MEMORY AND CONCENTRATION, AND THAT OF DELTA SIGNIFIES SYNCHRONIZATION OF BRAIN ACTIVITY. THE HEART RATE INDEX THETA/ALPHA DECREASED, NEURAL ACTIVITY BETA/THETA INCREASED, ATTENTION RESOURCE INDEX BETA/(ALPHA + THETA) INCREASED, EXECUTIVE LOAD INDEX (DELTA + THETA)/ALPHA DECREASED, AND THE RATIO (DELTA + THETA)/(ALPHA + BETA) DECREASED. THE YOGA PRACTICE GROUP SHOWED IMPROVEMENT IN HEART RATE VARIABILITY, INCREASED SDNN/RMSSD, AND REDUCTION IN LF/HF RATIO. CONCLUSION: YOGA PRACTISING GROUP SHOWED SIGNIFICANT IMPROVEMENT IN VARIOUS COGNITIVE FUNCTIONS, SUCH AS PERFORMANCE ENHANCEMENT, NEURAL ACTIVITY, ATTENTION, AND EXECUTIVE FUNCTION. IT ALSO RESULTED IN INCREASE IN THE HEART RATE VARIABILITY, PARASYMPATHETIC NERVOUS SYSTEM ACTIVITY, AND BALANCED AUTONOMIC NERVOUS SYSTEM REACTIVITY.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
13  962  30 EFFECTS OF A YOGA PROGRAM ON CORTISOL RHYTHM AND MOOD STATES IN EARLY BREAST CANCER PATIENTS UNDERGOING ADJUVANT RADIOTHERAPY: A RANDOMIZED CONTROLLED TRIAL. UNLABELLED: OBJECTIVES. THIS STUDY COMPARES THE EFFECTS OF AN INTEGRATED YOGA PROGRAM WITH BRIEF SUPPORTIVE THERAPY IN BREAST CANCER OUTPATIENTS UNDERGOING ADJUVANT RADIOTHERAPY AT A CANCER CENTER. METHODS: EIGHTY-EIGHT STAGE II AND III BREAST CANCER OUTPATIENTS ARE RANDOMLY ASSIGNED TO RECEIVE YOGA (N = 44) OR BRIEF SUPPORTIVE THERAPY (N = 44) PRIOR TO RADIOTHERAPY TREATMENT. ASSESSMENTS INCLUDE DIURNAL SALIVARY CORTISOL LEVELS 3 DAYS BEFORE AND AFTER RADIOTHERAPY AND SELF-RATINGS OF ANXIETY, DEPRESSION, AND STRESS COLLECTED BEFORE AND AFTER 6 WEEKS OF RADIOTHERAPY. RESULTS: ANALYSIS OF COVARIANCE REVEALS SIGNIFICANT DECREASES IN ANXIETY (P < .001), DEPRESSION (P = .002), PERCEIVED STRESS (P < .001), 6 A.M. SALIVARY CORTISOL (P = .009), AND POOLED MEAN CORTISOL (P = .03) IN THE YOGA GROUP COMPARED WITH CONTROLS. THERE IS A SIGNIFICANT POSITIVE CORRELATION BETWEEN MORNING SALIVARY CORTISOL LEVEL AND ANXIETY AND DEPRESSION. CONCLUSION: YOGA MIGHT HAVE A ROLE IN MANAGING SELF-REPORTED PSYCHOLOGICAL DISTRESS AND MODULATING CIRCADIAN PATTERNS OF STRESS HORMONES IN EARLY BREAST CANCER PATIENTS UNDERGOING ADJUVANT RADIOTHERAPY.	2009	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
14  297  36 ALTERNATE NOSTRIL BREATHING AT DIFFERENT RATES AND ITS INFLUENCE ON HEART RATE VARIABILITY IN NON PRACTITIONERS OF YOGA. INTRODUCTION: HEART RATE VARIABILITY IS A MEASURE OF MODULATION IN AUTONOMIC INPUT TO THE HEART AND IS ONE OF THE MARKERS OF AUTONOMIC FUNCTIONS. THOUGH THERE ARE MANY STUDIES ON THE LONG TERM INFLUENCE OF BREATHING ON HRV (HEART RATE VARIABILITY) THERE ARE ONLY A FEW STUDIES ON THE IMMEDIATE EFFECT OF BREATHING ESPECIALLY ALTERNATE NOSTRIL BREATHING ON HRV. THIS STUDY FOCUSES ON THE IMMEDIATE EFFECTS OF ALTERNATE NOSTRIL BREATHING AND THE INFLUENCE OF DIFFERENT BREATHING RATES ON HRV. MATERIALS AND METHODS: THE STUDY WAS DONE ON 25 SUBJECTS IN THE AGE GROUP OF 17-35 YEARS. ECG AND RESPIRATION WERE RECORDED BEFORE INTERVENTION AND IMMEDIATELY AFTER THE SUBJECTS WERE ASKED TO PERFORM ALTERNATE NOSTRIL BREATHING FOR FIVE MINUTES. RESULTS: LOW FREQUENCY (LF) WHICH IS A MARKER OF SYMPATHETIC ACTIVITY INCREASED, HIGH FREQUENCY (HF) WHICH IS A MARKER OF PARASYMPATHETIC ACTIVITY DECREASED AND THEIR RATIO LF/HF WHICH IS A MARKER OF SYMPATHO/VAGAL BALANCE INCREASED IMMEDIATELY AFTER 6 AND 12 MINUTES IN COMPARISON TO BASELINE VALUES WHEREAS THERE WAS NO SIGNIFICANT DIFFERENCE IN THE MEANS OF THESE COMPONENTS WHEN BOTH 6 AND 12 MINUTES WERE COMPARED. CONCLUSION: IMMEDIATE EFFECTS OF ALTERNATE NOSTRIL BREATHING ON HRV IN NON PRACTITIONERS OF YOGIC BREATHING ARE VERY DIFFERENT FROM THE LONG TERM INFLUENCE OF YOGIC BREATHING ON HRV WHICH SHOW A PREDOMINANT PARASYMPATHETIC INFLUENCE ON THE HEART.	2016	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
15  326  34 ANTIDEPRESSANT EFFICACY AND HORMONAL EFFECTS OF SUDARSHANA KRIYA YOGA (SKY) IN ALCOHOL DEPENDENT INDIVIDUALS. BACKGROUND: SUDARSHANA KRIYA YOGA (SKY) HAS DEMONSTRABLE ANTIDEPRESSANT EFFECTS. SKY WAS TESTED FOR THIS EFFECT IN INPATIENTS OF ALCOHOL DEPENDENCE. METHODS: FOLLOWING A WEEK OF DETOXIFICATION MANAGEMENT CONSENTING SUBJECTS (N=60) WERE EQUALLY RANDOMIZED TO RECEIVE SKY THERAPY OR NOT (CONTROLS) FOR A TWO-WEEK STUDY. SKY THERAPY INCLUDED ALTERNATE DAY PRACTICE OF SPECIFIED BREATHING EXERCISE UNDER SUPERVISION OF A TRAINED THERAPIST. SUBJECTS COMPLETED THE BECK DEPRESSION INVENTORY (BDI) BEFORE AND AFTER THE TWO WEEKS OF THIS INTERVENTION. MORNING PLASMA CORTISOL, ACTH AND PROLACTIN TOO WERE MEASURED BEFORE AND AT THE END OF TWO WEEKS. RESULTS: IN BOTH GROUPS REDUCTIONS IN BDI SCORES OCCURRED BUT SIGNIFICANTLY MORE SO IN SKY GROUP. LIKEWISE, IN BOTH GROUPS PLASMA CORTISOL AS WELL AS ACTH FELL AFTER TWO WEEKS BUT SIGNIFICANTLY MORE SO IN SKY GROUP. REDUCTION IN BDI SCORES CORRELATED WITH THAT IN CORTISOL IN SKY BUT NOT IN CONTROL GROUP. LIMITATIONS: ANTIDEPRESSANT EFFECTS OF SKY WERE DEMONSTRATED IN EARLY ABSTINENCE THAT ALSO HAD SUBSTANTIAL SPONTANEOUS IMPROVEMENT. IT IS NOT KNOWN IF THIS EFFECT CONTRIBUTES TO SUSTAINED ABSTINENCE. CONCLUSION: RESULTS EXTEND THE ANTIDEPRESSANT EFFECTS OF SKY IN ALCOHOL DEPENDENCE SUBJECTS. REDUCTION IN STRESS-HORMONE LEVELS (CORTISOL AND ACTH) ALONG WITH BDI REDUCTIONS POSSIBLY SUPPORT A BIOLOGICAL MECHANISM OF SKY IN PRODUCING BENEFICIAL EFFECTS.	2006	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
16 1605  32 MENTAL STRESS: NEUROPHYSIOLOGY AND ITS REGULATION BY SUDARSHAN KRIYA YOGA. AIM: THE PRESENT STUDY FOCUSES ON ANALYZING THE EFFECTS OF SUDARSHAN KRIYA YOGA (SKY) ON EEG AS WELL AS ECG SIGNALS FOR STRESS REGULATION. TO ENVISION THE REGULATION OF STRESS DETERMINATION TEST (DT) HAS BEEN USED. WE HAVE CHOSEN A CONTROL GROUP FOR CONTRIVING A COGENT COMPARISON THAT COULD BE CORROBORATED USING STATISTICAL TESTS. SUBJECTS AND METHODS: A TOTAL OF 20 SUBJECTS WERE TAKEN IN THE STUDY, OF WHICH 10 WERE ALLOTTED TO A CONTROL GROUP. ELECTROENCEPHALOGRAPH WAS TAKEN DURING A DT TASK, BEFORE AND AFTER SKY THE SKY SESSION WITH 30 DAYS OF SKY SESSION GIVEN TO THE EXPERIMENTAL GROUP. NO SKY WAS GIVEN TO THE CONTROL GROUP. RESULTS: WE QUANTIFIED MENTAL STRESS USING EEG, ECG AND DT SYNERGISTICALLY AND USED SKY TO REGULATE IT. WE OBSERVED THAT ALPHA BAND POWER DECREASES IN THE FRONTAL LOBE OF THE BRAIN WITH INCREASING MENTAL STRESS WHILE FRONTAL BRAIN ASYMMETRY DECREASES WITH INCREASING STRESS TOLERANCE. CONCLUSIONS: THESE EEG, ECG AND DT SHOWS A SIGNIFICANT DECREMENT IN MENTAL STRESS AND IMPROVEMENT IN COGNITIVE PERFORMANCE AFTER SKY, INDICATING SKY AS A GOOD ALTERNATIVE OF MEDICATION FOR STRESS MANAGEMENT.	2017	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
17  569  16 DECREASE IN SERUM CORTISOL DURING YOGA EXERCISE IS CORRELATED WITH ALPHA WAVE ACTIVATION. WE EXAMINED CHANGES IN BRAIN WAVES AND BLOOD LEVELS OF SERUM CORTISOL DURING YOGA EXERCISE IN 7 YOGA INSTRUCTORS AND FOUND THAT ALPHA WAVES INCREASED AND SERUM CORTISOL DECREASED. THESE TWO MEASURES WERE NEGATIVELY CORRELATED (R = -.83). COMPARISON WITH A CONTROL GROUP OF NONPRACTITIONERS IS DESIRABLE.	2000	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
18 1578  36 MEASUREMENT OF THE EFFECT OF ISHA YOGA ON CARDIAC AUTONOMIC NERVOUS SYSTEM USING SHORT-TERM HEART RATE VARIABILITY. BACKGROUND: BENEFICIAL EFFECTS OF YOGA HAVE BEEN POSTULATED TO BE DUE TO MODULATION OF THE AUTONOMIC NERVOUS SYSTEM. OBJECTIVE: TO ASSESS THE EFFECT OF ISHA YOGA PRACTICES ON CARDIOVASCULAR AUTONOMIC NERVOUS SYSTEM THROUGH SHORT-TERM HEART RATE VARIABILITY (HRV). DESIGN OF THE STUDY: SHORT-TERM HRV OF LONG-TERM REGULAR HEALTHY 14 (12 MALES AND 2 FEMALES) ISHA YOGA PRACTITIONERS WAS COMPARED WITH THAT OF AGE- AND GENDER-MATCHED 14 (12 MALES AND 2 FEMALES) NON-YOGA PRACTITIONERS. METHODS AND MATERIALS: ECG LEAD II AND RESPIRATORY MOVEMENTS WERE RECORDED IN BOTH GROUPS USING POLYRITE DURING SUPINE REST FOR 5 MIN AND CONTROLLED DEEP BREATHING FOR 1 MINUTE. FREQUENCY DOMAIN ANALYSIS [RR INTERVAL IS THE MEAN OF DISTANCE BETWEEN SUBSEQUENT R WAVE PEAKS IN ECG], LOW FREQUENCY (LF) POWER, HIGH FREQUENCY (HF) POWER, LF NORMALIZED UNITS (NU), HF NU, LF/HF RATIO] AND TIME DOMAIN ANALYSIS [STANDARD DEVIATION OF NORMAL TO NORMAL INTERVAL (SDNN), SQUARE OF MEAN SQUARED DIFFERENCE OF SUCCESSIVE NORMAL TO NORMAL INTERVALS (RMSSD), NORMAL TO NORMAL INTERVALS WHICH ARE DIFFERING BY 50 MS (NN50), AND PERCENTAGE OF NN50 (PNN50)] OF HRV VARIABLES WERE ANALYZED FOR SUPINE REST. TIME DOMAIN ANALYSIS WAS RECORDED FOR DEEP BREATHING. RESULTS: RESULTS SHOWED STATISTICALLY SIGNIFICANT DIFFERENCES BETWEEN ISHA YOGA PRACTITIONERS AND CONTROLS IN BOTH FREQUENCY AND TIME DOMAIN ANALYSES OF HRV INDICES, WITH NO DIFFERENCE IN RESTING HEART RATE BETWEEN THE GROUPS. CONCLUSIONS: PRACTITIONERS OF ISHA YOGA SHOWED WELL-BALANCED BENEFICIAL ACTIVITY OF VAGAL EFFERENTS, AN OVERALL INCREASED HRV, AND SYMPATHOVAGAL BALANCE, COMPARED TO NON-YOGA PRACTITIONERS DURING SUPINE REST AND DEEP BREATHING.	2012	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
19 1353  38 IMMEDIATE EFFECT OF SPECIFIC NOSTRIL MANIPULATING YOGA BREATHING PRACTICES ON AUTONOMIC AND RESPIRATORY VARIABLES. THE EFFECT OF RIGHT, LEFT, AND ALTERNATE NOSTRIL YOGA BREATHING (I.E., RNYB, LNYB, AND ANYB, RESPECTIVELY) WERE COMPARED WITH BREATH AWARENESS (BAW) AND NORMAL BREATHING (CTL). AUTONOMIC AND RESPIRATORY VARIABLES WERE STUDIED IN 21 MALE VOLUNTEERS WITH AGES BETWEEN 18 AND 45 YEARS AND EXPERIENCE IN THE YOGA BREATHING PRACTICES BETWEEN 3 AND 48 MONTHS. SUBJECTS WERE ASSESSED IN FIVE EXPERIMENTAL SESSIONS ON FIVE SEPARATE DAYS. THE SESSIONS WERE IN FIXED POSSIBLE SEQUENCES AND SUBJECTS WERE ASSIGNED TO A SEQUENCE RANDOMLY. EACH SESSION WAS FOR 40 MIN; 30 MIN FOR THE BREATHING PRACTICE, PRECEDED AND FOLLOWED BY 5 MIN OF QUIET SITTING. ASSESSMENTS INCLUDED HEART RATE VARIABILITY, SKIN CONDUCTANCE, FINGER PLETHYSMOGRAM AMPLITUDE, BREATH RATE, AND BLOOD PRESSURE. FOLLOWING RNYB THERE WAS A SIGNIFICANT INCREASE IN SYSTOLIC, DIASTOLIC AND MEAN PRESSURE. IN CONTRAST, THE SYSTOLIC AND DIASTOLIC PRESSURE DECREASED AFTER ANYB AND THE SYSTOLIC AND MEAN PRESSURE WERE LOWER AFTER LNYB. HENCE, UNILATERAL NOSTRIL YOGA BREATHING PRACTICES APPEAR TO INFLUENCE THE BLOOD PRESSURE IN DIFFERENT WAYS. THESE EFFECTS SUGGEST POSSIBLE THERAPEUTIC APPLICATIONS.	2008	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
20 1012  33 EFFECTS OF ONE MONTH OF COMMON YOGA PROTOCOL PRACTICE APPEAR TO BE MEDIATED BY THE ANGIOGENIC AND NEUROGENIC PATHWAY: A PILOT STUDY. OBJECTIVE: TO EXAMINE THE MOLECULAR EFFECTS OF MINDFUL ACTIVITIES SUCH AS YOGA AND MEDITATION DESIGN: THIS WAS AN OPEN LABEL SINGLE ARM EXPLORATORY YOGA INTERVENTION STUDY. STUDY PARTICIPANTS: 64 HEALTHY INDIVIDUALS WITHIN THE AGE OF 18-60 YEARS WERE RECRUITED FOR THIS ONE MONTH YOGA INTERVENTION STUDY. INTERVENTION: COMMON YOGA PROTOCOL (CYP) IS A STANDARDIZED YOGA PROTOCOL RELEASED BY MINISTRY OF AYUSH, INDIA FOR INTERNATIONAL YOGA DAY. IT INCLUDES ALL ASPECTS OF YOGA I.E. ASANAS, PRANAYAMA AND MEDITATION. IT IS DESIGNED FOR ADOPTION BY ALL AGE GROUPS FOR THE HEALTH OF COMMUNITY. OUTCOME MEASURES: THE PARTICIPANTS WERE ASSESSED FOR BIOCHEMICAL PARAMETERS INCLUDING FASTING SUGAR AND LIPID PROFILE. THE MOLECULAR MARKERS OF NEUROGENESIS (I.E. BRAIN DERIVED NEUROTROPIC FACTOR, BDNF) AND ANGIOGENESIS (I.E. VASCULAR ENDOTHELIAL GROWTH FACTOR, VEGF AND ANGIOGENIN) ALONG WITH AMYLOID BETA (MARKER RELATED TO NEURO-DEGENERATIVE DISEASES) WERE ASSESSED. ALL THE ASSESSMENTS WERE MADE AT BASELINE AND AFTER ONE MONTH OF THE INTERVENTION. RESULTS: AFTER ONE MONTH OF CYP PRACTICE HIGH DENSITY LIPOPROTEIN (HDL) LEVELS INCREASED SIGNIFICANTLY (P<0.001), ALTHOUGH OTHER BIOCHEMICAL PARAMETERS I.E. FASTING SUGAR AND OTHER LIPID ASSESSMENTS WERE FOUND TO BE UNALTERED. ANGIOGENESIS MARKER, ANGIOGENIN WAS INCREASED SIGNIFICANTLY (P<0.002), OTHER ANGIOGENESIS MARKER VEGF DID NOT SHOW ANY CHANGE ALONG WITH BDNF, MARKER OF NEUROGENESIS. AMYLOID BETA LEVELS WERE ALSO UNALTERED. EVEN THOUGH INDIVIDUAL LEVELS OF VEGF AND AMYLOID BETA DID NOT SHOW ANY CHANGE, PROPORTION OF VEGF TO AMYLOID BETA SHOWED A SIGNIFICANT INCREASE (P<0.001) AFTER ONE MONTH OF CYP INTERVENTION INDICATING THAT THE CHANGE IN VEGF LEVELS WAS SIGNIFICANTLY HIGHER THAN THE CHANGE IN AMYLOID BETA LEVELS. CONCLUSION: CYP PRACTICE MAY INFLUENCE CELL SURVIVAL PATHWAYS MEDIATED BY ANGIOGENIC AND NEUROGENIC CROSS TALK. HENCE, CYP CAN BE CONSIDERED AS A PREVENTIVE MEASURE FOR DISEASES ASSOCIATED WITH IMPAIRED ANGIOGENIC AND NEUROGENIC MECHANISM. THIS IS THE FIRST STUDY TO EXAMINE THE EFFECTS OF CYP AT THE MOLECULAR LEVEL.	2021