1 2847 160 YOGA, MEDITATION AND MIND-BODY HEALTH: INCREASED BDNF, CORTISOL AWAKENING RESPONSE, AND ALTERED INFLAMMATORY MARKER EXPRESSION AFTER A 3-MONTH YOGA AND MEDITATION RETREAT. THIRTY-EIGHT INDIVIDUALS (MEAN AGE: 34.8 YEARS OLD) PARTICIPATING IN A 3-MONTH YOGA AND MEDITATION RETREAT WERE ASSESSED BEFORE AND AFTER THE INTERVENTION FOR PSYCHOMETRIC MEASURES, BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF), CIRCADIAN SALIVARY CORTISOL LEVELS, AND PRO- AND ANTI-INFLAMMATORY CYTOKINES. PARTICIPATION IN THE RETREAT WAS FOUND TO BE ASSOCIATED WITH DECREASES IN SELF-REPORTED ANXIETY AND DEPRESSION AS WELL AS INCREASES IN MINDFULNESS. AS HYPOTHESIZED, INCREASES IN THE PLASMA LEVELS OF BDNF AND INCREASES IN THE MAGNITUDE OF THE CORTISOL AWAKENING RESPONSE (CAR) WERE ALSO OBSERVED. THE NORMALIZED CHANGE IN BDNF LEVELS WAS INVERSELY CORRELATED WITH BSI-18 ANXIETY SCORES AT BOTH THE PRE-RETREAT (R = 0.40, P < 0.05) AND POST-RETREAT (R = 0.52, P < 0.005) SUCH THAT THOSE WITH GREATER ANXIETY SCORES TENDED TO EXHIBIT SMALLER PRE- TO POST-RETREAT INCREASES IN PLASMA BDNF LEVELS. IN LINE WITH A HYPOTHESIZED DECREASE IN INFLAMMATORY PROCESSES RESULTING FROM THE YOGA AND MEDITATION PRACTICES, WE FOUND THAT THE PLASMA LEVEL OF THE ANTI-INFLAMMATORY CYTOKINE INTERLEUKIN-10 WAS INCREASED AND THE PRO-INFLAMMATORY CYTOKINE INTERLEUKIN-12 WAS REDUCED AFTER THE RETREAT. CONTRARY TO OUR INITIAL HYPOTHESES, PLASMA LEVELS OF OTHER PRO-INFLAMMATORY CYTOKINES, INCLUDING INTERFERON GAMMA (IFN-GAMMA), TUMOR NECROSIS FACTOR (TNF-ALPHA), INTERLEUKIN-1BETA (IL-1BETA), INTERLEUKIN-6 (IL-6), AND INTERLEUKIN-8 (IL-8) WERE INCREASED AFTER THE RETREAT. GIVEN EVIDENCE FROM PREVIOUS STUDIES OF THE POSITIVE EFFECTS OF MEDITATIVE PRACTICES ON MENTAL FITNESS, AUTONOMIC HOMEOSTASIS AND INFLAMMATORY STATUS, WE HYPOTHESIZE THAT THESE FINDINGS ARE RELATED TO THE MEDITATIVE PRACTICES THROUGHOUT THE RETREAT; HOWEVER, SOME OF THE OBSERVED CHANGES MAY ALSO BE RELATED TO OTHER ASPECTS OF THE RETREAT SUCH AS PHYSICAL EXERCISE-RELATED COMPONENTS OF THE YOGA PRACTICE AND DIET. WE HYPOTHESIZE THAT THE PATTERNS OF CHANGE OBSERVED HERE REFLECT MIND-BODY INTEGRATION AND WELL-BEING. THE INCREASED BDNF LEVELS OBSERVED IS A POTENTIAL MEDIATOR BETWEEN MEDITATIVE PRACTICES AND BRAIN HEALTH, THE INCREASED CAR IS LIKELY A REFLECTION OF INCREASED DYNAMIC PHYSIOLOGICAL AROUSAL, AND THE RELATIONSHIP OF THE DUAL ENHANCEMENT OF PRO- AND ANTI-INFLAMMATORY CYTOKINE CHANGES TO HEALTHY IMMUNOLOGIC FUNCTIONING IS DISCUSSED.	2017	
                                                                                                                                                                                                                                                                                
2 1273  34 FRONTAL HEMODYNAMIC RESPONSES TO HIGH FREQUENCY YOGA BREATHING IN SCHIZOPHRENIA: A FUNCTIONAL NEAR-INFRARED SPECTROSCOPY STUDY. FRONTAL HEMODYNAMIC RESPONSES TO HIGH FREQUENCY YOGA BREATHING TECHNIQUE, KAPALABHATI (KB), WERE COMPARED BETWEEN PATIENTS OF SCHIZOPHRENIA (N = 18; 14 MALES, 4 FEMALES) AND AGE, GENDER, AND EDUCATION MATCHED HEALTHY SUBJECTS (N = 18; 14 MALES, 4 FEMALES) USING FUNCTIONAL NEAR-INFRARED SPECTROSCOPY. THE DIAGNOSIS WAS CONFIRMED BY A PSYCHIATRIST USING DSM-IV. ALL PATIENTS EXCEPT ONE RECEIVED ATYPICAL ANTIPSYCHOTICS (ONE WAS ON TYPICAL). THEY HAD OBTAINED A STABILIZED STATE AS EVIDENCED BY A STEADY UNCHANGED MEDICATION FROM THEIR PSYCHIATRIST FOR THE PAST 3 MONTHS OR LONGER. THEY LEARNED KB, AMONG OTHER YOGA PROCEDURES, IN A YOGA RETREAT. KB WAS PRACTICED AT THE RATE OF 120 TIMES/MIN FOR 1 MIN. HEALTHY SUBJECTS WHO WERE FRESHLY LEARNING YOGA TOO WERE TAUGHT KB. BOTH THE GROUPS HAD NO PREVIOUS EXPOSURE TO KB PRACTICE AND THE TRAINING WAS CARRIED OUT OVER 2 WEEKS. A CHEST PRESSURE TRANSDUCER WAS USED TO MONITOR THE FREQUENCY AND INTENSITY OF THE PRACTICE OBJECTIVELY. THE FRONTAL HEMODYNAMIC RESPONSE IN TERMS OF THE OXYGENATED HEMOGLOBIN (OXYHB), DEOXYGENATED HEMOGLOBIN (DEOXYHB), AND TOTAL HEMOGLOBIN (TOTALHB) OR BLOOD VOLUME CONCENTRATION WAS TAPPED FOR 5 MIN BEFORE, 1 MIN DURING, AND FOR 5 MIN AFTER KB. THIS WAS OBTAINED IN A QUIET ROOM USING A 16-CHANNEL FUNCTIONAL NEAR-INFRARED SYSTEM (FNIR100-ACK-W, BIOPAC SYSTEMS, INC., USA). THE AVERAGE OF THE EIGHT CHANNELS FOR EACH SIDE (RIGHT AND LEFT FRONTALS) WAS OBTAINED FOR THE THREE SESSIONS. THE CHANGES IN THE LEVELS OF OXYHB, DEOXYHB, AND BLOOD VOLUME FOR THE THREE SESSIONS WERE COMPARED BETWEEN THE TWO GROUPS USING INDEPENDENT SAMPLES T-TEST. WITHIN GROUP COMPARISON SHOWED THAT THE INCREASE IN BILATERAL OXYHB AND TOTALHB FROM THE BASELINE WAS HIGHLY SIGNIFICANT IN HEALTHY CONTROLS DURING KB (RIGHT OXYHB, P = 0.00; LEFT OXYHB, P = 0.00 AND RIGHT TOTALHB, P = 0.01; LEFT TOTALHB, P = 0.00), WHEREAS SCHIZOPHRENIA PATIENTS DID NOT SHOW ANY SIGNIFICANT CHANGES IN THE SAME ON BOTH THE SIDES. ON THE OTHER HAND, SCHIZOPHRENIA PATIENTS SHOWED SIGNIFICANT REDUCTION IN DEOXYHB IN THE RIGHT PRE-FRONTAL CORTEX (RIGHT DEOXYHB, P = 0.00). COMPARISON BETWEEN THE GROUPS SHOWED THAT SCHIZOPHRENIA PATIENTS HAVE REDUCED BILATERAL PRE-FRONTAL ACTIVATION (RIGHT OXYHB, P = 0.01; LEFT OXYHB, P = 0.03 AND RIGHT TOTAL HB, P = 0.03; LEFT TOTAL HB, P = 0.04) DURING KB AS COMPARED TO HEALTHY CONTROLS. THIS HYPO-FRONTALITY OF SCHIZOPHRENIA PATIENTS IN RESPONSE TO KB MAY BE USED CLINICALLY TO SUPPORT THE DIAGNOSIS OF SCHIZOPHRENIA IN FUTURE.	2014	
                                                                                                                        
3 2067  34 THE CONSCIOUSNESS STATE OF TRADITIONAL NIDRA YOGA/MODERN YOGA NIDRA: PHENOMENOLOGICAL CHARACTERIZATION AND PRELIMINARY INSIGHTS FROM AN EEG STUDY. NIDRA YOGA IS AN ANCIENT YOGIC PRACTICE CAPABLE OF INDUCING ALTERED STATES OF CONSCIOUSNESS CHARACTERIZED BY DEEP RELAXATION, STRONG CONCENTRATION, ACUTE SELF-AWARENESS, AND JOY. IN MODERN CONTEMPLATIVE NEUROSCIENCE LANGUAGE, IT IS KNOWN BY THE NAME YOGA NIDRA, AND FEW STUDIES HAVE INVESTIGATED ITS PHENOMENOLOGICAL AND PSYCHOPHYSIOLOGICAL EFFECTS. SIX HEALTHY VOLUNTEERS (FOUR FEMALES AGED 31-74) PERFORMED 12 YOGA NIDRA SESSIONS GUIDED BY AN EXPERT DURING A 6-DAY RETREAT. EACH SESSION CONSISTED OF 10 MINUTES IN A RESTING STATE (BASELINE) FOLLOWED BY 2 HOURS OF YOGA NIDRA. PSYCHOMETRIC DATA REGARDING DISSOCIATIVE EXPERIENCES (CLINICIAN ADMINISTERED DISSOCIATIVE STATES SCALE) AND THE STATE OF CONSCIOUSNESS (PHENOMENOLOGY OF CONSCIOUSNESS INVENTORY) WERE COLLECTED AFTER BASELINE AND YOGA NIDRA, WHILE HIGH-DENSITY EEG WAS RECORDED DURING THE ENTIRE SESSION. DURING NIDRA SESSIONS, NO SLEEP HALLMARKS (I.E., K-COMPLEXES AND SLEEP SPINDLES) WERE DETECTED BY THE EEG IN ANY SUBJECT. PSYCHOMETRIC DATA WE RE ANALYZED USING A WILCOXON SIGNED-RANK TEST CORRECTED WITH THE FALSE DISCOVERY RATE APPROACH FOR MULTIPLE COMPARISONS. COMPARED TO BASELINE, YOGA NIDRA PRACTICE WAS RELATED TO: (1) INCREASED DISSOCIATIVE EFFECTS (P = 0.022); (2) PERCEPTION OF BEING IN AN ALTERED STATE OF CONSCIOUSNESS (P = 0.026); (3) ALTERATIONS IN PERCEIVED BODY IMAGE (P = 0.022); (4) INCREASED "MEANINGFULNESS" ATTRIBUTED TO THE EXPERIENCE (P = 0.026); (5) REDUCED RATIONAL THINKING (P = 0.029); AND (6) REDUCED VOLITIONAL THOUGHT CONTROL (P = 0.026). FIRST-PERSON EXPERIENCE IS DISCUSSED IN RELATION TO DESCRIPTIVE EEG POWER SPECTRAL DENSITY ANALYSIS, WHICH WAS PERFORMED IN ONE SUBJECT BECAUSE OF SEVERE EEG ARTIFACTS IN THE OTHER RECORDINGS; THAT SUBJECT SHOWED, COMPARED TO BASELINE: (1) EARLY INCREASE OF ALPHA AND BETA POWER, FOLLOWED BY A PROGRESSIVE WIDESPREAD REDUCTION; (2) WIDESPREAD EARLY INCREASE OF THETA POWER, FOLLOWED BY A PROGRESSIVE REDUCTION; AND (3) WIDESPREAD INCREASE OF GAMMA POWER IN THE LATEST STAGES. THE PRESENT PRELIMINARY RESULTS ENRICH THE KNOWLEDGE OF YOGA NIDRA, ELUCIDATING ITS PHENOMENOLOGY AND SUGGESTING SOME PSYCHOPHYSIOLOGICAL CORRELATES THAT FUTURE STUDIES MAY ADDRESS.	2021	
                                                                                                                                                                                                                                                                                                                                                                                                                           
4 1521  48 ISHA YOGA PRACTICES AND PARTICIPATION IN SAMYAMA PROGRAM ARE ASSOCIATED WITH REDUCED HBA1C AND SYSTEMIC INFLAMMATION, IMPROVED LIPID PROFILE, AND SHORT-TERM AND SUSTAINED IMPROVEMENT IN MENTAL HEALTH: A PROSPECTIVE OBSERVATIONAL STUDY OF MEDITATORS. BACKGROUND: MEDITATION IS GAINING RECOGNITION AS A TOOL TO IMPACT HEALTH AND WELL-BEING. SAMYAMA IS AN 8-DAY INTENSIVE RESIDENTIAL MEDITATION EXPERIENCE CONDUCTED BY ISHA FOUNDATION REQUIRING SEVERAL MONTHS OF EXTENSIVE PREPARATION AND VEGAN DIET. THE HEALTH EFFECTS OF SAMYAMA HAVE NOT BEEN PREVIOUSLY STUDIED. THE OBJECTIVE WAS TO ASSESS PHYSICAL AND EMOTIONAL WELL-BEING BEFORE AND AFTER SAMYAMA PARTICIPATION BY EVALUATING PSYCHOLOGICAL SURVEYS AND OBJECTIVE HEALTH BIOMARKERS. METHODS: THIS WAS AN OBSERVATIONAL STUDY OF 632 ADULTS BEFORE AND AFTER THE ISHA SAMYAMA RETREAT. ALL PARTICIPANTS WERE INVITED TO COMPLETE SURVEYS. CONTROLS INCLUDED HOUSEHOLD SIGNIFICANT OTHERS. SURVEYS WERE COMPLETED AT BASELINE (T1), JUST BEFORE SAMYAMA (T2), IMMEDIATELY AFTER SAMYAMA (T3), AND 3 MONTHS LATER (T4) TO ASSESS ANXIETY, DEPRESSION, MINDFULNESS, JOY, VITALITY, AND RESILIENCE THROUGH VALIDATED PSYCHOMETRIC SCALES. VOLUNTARY BLOOD SAMPLING FOR BIOMARKER ANALYSIS WAS DONE TO ASSESS HEMOGLOBIN (HB), HBA1C, LIPID PROFILE, AND C-REACTIVE PROTEIN (CRP). PRIMARY OUTCOMES WERE CHANGES IN PSYCHOMETRIC SCORES, BODY WEIGHT, AND BLOOD BIOMARKERS. RESULTS: DEPRESSION AND ANXIETY SCORES DECREASED FROM T1 TO T3, WITH THE EFFECT MOST PRONOUNCED IN PARTICIPANTS WITH BASELINE DEPRESSION OR ANXIETY. SCORES AT T4 REMAINED BELOW BASELINE FOR THOSE WITH PRE-EXISTING DEPRESSION OR ANXIETY. VITALITY, RESILIENCE, JOY, AND MINDFULNESS INCREASED FROM T1 TO T3 (SUSTAINED AT T4). BODY WEIGHT DECREASED BY 3% FROM T1 TO T3. TRIGLYCERIDES (TG) WERE LOWER FROM T2 TO T3. PARTICIPANTS HAD LOWER HBA1C AND HDL AT T2, AND LOWER CRP AT ALL TIMEPOINTS COMPARED WITH CONTROLS. CONCLUSIONS: PARTICIPATION IN THE ISHA SAMYAMA PROGRAM LED TO MULTIPLE BENEFITS. THE 2-MONTH PREPARATION REDUCED ANXIETY, AND PARTICIPANTS MAINTAINED LOWER ANXIETY LEVELS AT 3 MONTHS POST-RETREAT. PHYSICAL HEALTH IMPROVED OVER THE COURSE OF THE PROGRAM AS EVIDENCED BY WEIGHT LOSS AND IMPROVED HBA1C AND LIPID PROFILE. PRACTICES ASSOCIATED WITH THE SAMYAMA PREPARATION PHASE AND THE RETREAT MAY SERVE AS AN EFFECTIVE WAY TO IMPROVE PHYSICAL AND MENTAL HEALTH. FUTURE STUDIES MAY EXAMINE THEIR USE AS AN ALTERNATIVE THERAPY IN PATIENTS WITH DEPRESSION AND/OR ANXIETY. CLINICAL TRIAL REGISTRATION: WWW.CLINICALTRIALS.GOV, IDENTIFIER: 1801728792. REGISTERED RETROSPECTIVELY ON 4/17/2020.	2021	
                                                                                                                                                                    
5  770  29 EFFECT OF UNINOSTRIL YOGA BREATHING ON BRAIN HEMODYNAMICS: A FUNCTIONAL NEAR-INFRARED SPECTROSCOPY STUDY. OBJECTIVES: TO MEASURE THE EFFECT OF THE RIGHT AND LEFT NOSTRIL YOGA BREATHING ON FRONTAL HEMODYNAMIC RESPONSES IN 32 RIGHT HANDED HEALTHY MALE SUBJECTS WITHIN THE AGE RANGE OF 18-35 YEARS (23.75 +/- 4.14 YEARS). MATERIALS AND METHODS: EACH SUBJECT PRACTICED RIGHT NOSTRIL YOGA BREATHING (RNYB), LEFT NOSTRIL YOGA BREATHING (LNYB) OR BREATH AWARENESS (BA) (AS CONTROL) FOR 10 MIN AT THE SAME TIME OF THE DAY FOR THREE CONSECUTIVE DAYS, RESPECTIVELY. THE SEQUENCE OF INTERVENTION WAS ASSIGNED RANDOMLY. THE FRONTAL HEMODYNAMIC RESPONSE IN TERMS OF CHANGES IN THE OXYGENATED HEMOGLOBIN (OXYHB), DEOXYGENATED HEMOGLOBIN (DEOXYHB), AND TOTAL HEMOGLOBIN (TOTALHB OR BLOOD VOLUME) CONCENTRATION WAS TAPPED FOR 5 MIN BEFORE (PRE) AND 10 MIN DURING THE BREATHING PRACTICES USING A 16 CHANNEL FUNCTIONAL NEAR-INFRARED SYSTEM (FNIR100-ACK-W, BIOPAC SYSTEMS, INC., U.S.A.). AVERAGE OF THE EIGHT CHANNELS ON EACH SIDE (RIGHT AND LEFT FRONTALS) WAS OBTAINED FOR THE TWO SESSIONS (PRE AND DURING). DATA WAS ANALYZED USING SPSS VERSION 10.0 THROUGH PAIRED AND INDEPENDENT SAMPLES T-TEST. RESULTS: WITHIN GROUP COMPARISON SHOWED THAT DURING RNYB, OXYHB LEVELS INCREASED SIGNIFICANTLY IN THE LEFT PREFRONTAL CORTEX (PFC) AS COMPARED TO THE BASELINE (P = 0.026). LNYB SHOWED A TREND TOWARDS SIGNIFICANCE FOR REDUCTION IN OXYHB IN THE RIGHT HEMISPHERE (P = 0.057). WHEREAS BA CAUSED SIGNIFICANT REDUCTION IN DEOXYHB (P = 0.023) IN THE LEFT HEMISPHERE. BETWEEN GROUPS COMPARISON REVEALED THAT OXYHB AND BLOOD VOLUME IN THE LEFT PFC INCREASED SIGNIFICANTLY DURING RNYB AS COMPARED TO BA (OXYHB: P =0.012; TOTALHB: P =0.017) AND LNYB (OXYHB: P =0.024; TOTALHB: P =0.034). CONCLUSION: RNYB INCREASED OXYGENATION AND BLOOD VOLUME IN THE LEFT PFC AS COMPARED TO BA AND LNYB. THIS SUPPORTS THE RELATIONSHIP BETWEEN NASAL CYCLE AND ULTRADIAN RHYTHM OF CEREBRAL DOMINANCE AND SUGGESTS A POSSIBLE APPLICATION OF UNINOSTRIL YOGA BREATHING IN THE MANAGEMENT OF PSYCHOPATHOLOGICAL STATES WHICH SHOW LATERALIZED CEREBRAL DYSFUNCTIONS.	2016	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
6 1771  39 POTENTIAL ROLE OF YOGA IN THE MANAGEMENT OF ANKYLOSING SPONDYLITIS: A RETROSPECTIVE STUDY. BACKGROUND: ANKYLOSING SPONDYLITIS (AS) IS A CHRONIC AUTOIMMUNE INFLAMMATORY SPONDYLOARTHROPATHY WITH UNCLEAR PATHOGENESIS. THE INFLAMMATORY PAIN IN AS LEADS TO RESTRICTED SPINAL MOBILITY AND SIGNIFICANT DISABILITY. YOGA IS A NONPHARMACOLOGICAL INTERVENTION THAT HAS POSITIVE EFFECTS ON VARIOUS MUSCULOSKELETAL-RELATED PROBLEMS. HOWEVER, ITS ROLE IN AS IS UNKNOWN. OBJECTIVE: THE PRESENT RETROSPECTIVE STUDY ASSESSED THE EFFICACY OF A TWO-WEEK RESIDENTIAL YOGA INTERVENTION ON SPINAL FLEXIBILITY AMONG AS PATIENTS. METHODS: THE RECORDS FOR 24 MALE AS PATIENTS WITHIN THE AGE RANGE 30 TO 50 YEARS (AVERAGE AGE 38.3 +/- 10.5 YEARS) WHO UNDERWENT A TWO-WEEK RESIDENTIAL YOGA RETREAT BETWEEN 2015 AND 2020 WERE OBTAINED FROM A YOGA CENTER LOCATED IN SOUTH INDIA. YOGA INTERVENTION CONSISTED OF YOGA POSTURES, BREATHING PRACTICES, MEDITATION, A HEALTHY DIET, AND DEVOTIONAL SESSIONS. PRE AND POST DATA OF THE SIT-AND-REACH TEST, BLOOD PRESSURE, HEART RATE, AND SYMPTOM SCORE WERE ANALYZED USING STATISTICAL PACKAGE FOR SOCIAL SCIENCES (SPSS). RESULTS: COMPARED TO THE BASELINE, THE POST SCORES OF THE SIT-AND-REACH TEST, SYSTOLIC BLOOD PRESSURE AND HEART RATE WERE FOUND TO BE SIGNIFICANTLY (P < .05) LOWER. THE SYMPTOM SCORE AND ANALGESIC MEDICATION SCORE ALSO SHOWED SIGNIFICANT IMPROVEMENT AFTER TWO-WEEKS COMPARED TO THE BASELINE. CONCLUSION: THIS RETROSPECTIVE STUDY INDICATES THE POSITIVE IMPACT OF ON AND ANALGESIC USE AMONG AS PATIENTS. HOWEVER, ADDITIONAL STUDIES USING ROBUST RESEARCH DESIGNS ARE WARRANTED.	2021	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
7 1336  36 HOW DOES YOGA REDUCE STRESS? A CLINICAL TRIAL TESTING PSYCHOLOGICAL MECHANISMS. YOGA INTERVENTIONS CAN REDUCE STRESS, BUT THE MECHANISMS UNDERLYING THAT STRESS REDUCTION REMAIN LARGELY UNIDENTIFIED. UNDERSTANDING HOW YOGA WORKS IS ESSENTIAL TO OPTIMIZING INTERVENTIONS. THE PRESENT STUDY TESTED FIVE POTENTIAL PSYCHOSOCIAL MECHANISMS (INCREASED MINDFULNESS, INTEROCEPTIVE AWARENESS, SPIRITUAL WELL-BEING, SELF-COMPASSION AND SELF-CONTROL) THAT HAVE BEEN PROPOSED TO EXPLAIN YOGA'S IMPACT ON STRESS. FORTY-TWO PARTICIPANTS (62% FEMALE; 64% WHITE) IN A YOGA PROGRAM FOR STRESS REDUCTION COMPLETED SURVEYS AT BASELINE (T1), MID-INTERVENTION (T2) AND POST-INTERVENTION (12 WEEKS; T3). WE MEASURED TWO ASPECTS OF STRESS, PERCEIVED STRESS AND STRESS REACTIVITY. CHANGES WERE ASSESSED WITH PAIRED T-TESTS; ASSOCIATIONS BETWEEN CHANGES IN MECHANISMS WERE TESTED IN RESIDUAL CHANGE MODELS. ONLY STRESS REACTIVITY DECREASED, ON AVERAGE, FROM T1 TO T3. EXCEPT FOR SELF-COMPASSION, ALL PSYCHOSOCIAL MECHANISMS INCREASED FROM T1 TO T3, WITH MINIMAL CHANGES FROM T2 TO T3. EXCEPT FOR SELF-CONTROL, INCREASES IN EACH MECHANISM WERE STRONGLY ASSOCIATED WITH DECREASES IN BOTH MEASURES OF STRESS BETWEEN T1 AND T2 AND DECREASES IN PERCEIVED STRESS FROM T1 TO T3 (ALL P'S < 0.05). INCREASED PSYCHOSOCIAL RESOURCES ARE ASSOCIATED WITH STRESS REDUCTION. YOGA INTERVENTIONS TARGETING THESE RESOURCES MAY SHOW STRONGER STRESS REDUCTION EFFECTS. FUTURE RESEARCH SHOULD TEST THESE LINKAGES MORE RIGOROUSLY USING ACTIVE COMPARISON GROUPS AND LARGER SAMPLES.	2021	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
8   10  26 "MAKING IT OKAY": PROFESSIONALS IN HIGH-STRESS ENVIRONMENTS CONSTRUCT THEIR UNDERSTANDING OF THE IMPACT OF A YOGA-BASED RETREAT DESIGNED TO BUILD RESILIENCE. PURPOSE: WHILE THERE IS GROWING EVIDENCE FOR RESILIENCE BUILDING PROGRAMMES, TO DATE RESEARCH HAS NOT EXPLORED HOW PROFESSIONALS CONSTRUCT UNDERSTANDING OF PROGRAMME IMPACT. RISE (RESILIENCE, INTEGRATION, SELF-AWARENESS, ENGAGEMENT), A 5-DAY YOGA-BASED RETREAT PROGRAMME, HAS BEEN LINKED WITH POSITIVE WELLNESS OUTCOMES. THIS QUALITATIVE INQUIRY EXPLORES PARTICIPANTS' REFLECTION AND EXPERIENCE 3 MONTHS AFTER PROGRAMME COMPLETION. METHODS: THROUGH A GROUNDED CONSTRUCTIVIST LENS, IN-DEPTH SEMI-STRUCTURED PHONE INTERVIEWS WERE CONDUCTED WITH 17 ADULT PROFESSIONALS IN HIGH-STRESS WORK ENVIRONMENTS WHO ATTENDED RISE. INITIAL HAND-CODING INFORMED CODEBOOK DEVELOPMENT FOR SYSTEMATIC CODING USING DIRECTED CONTENT ANALYSIS USING SENSITIZING STRUCTURING. RESULTS: TWO INTEGRATED PERCEPTIONS WOVEN THROUGH FIVE THEMES. PERSISTENT THREADS OF EXPERIENTIAL LEARNING AND SENSE OF PERMISSION PROVIDED STRUCTURE FOR THEMES FOUND. FIVE INTERRELATED THEMES RELATED TO PSYCHOLOGICAL HEALTH AND WORKPLACE DYNAMICS WERE (1) USE OF ACQUIRED BEHAVIOURAL SKILLS AND PRACTICES; (2) LIVED MINDFULNESS; (3) RESILIENCE TO STRESS AND EMOTION REGULATION (4) SELF-CARE AND SELF-COMPASSION, AND (5) SHARING WITH OTHERS. CONCLUSION: FINDINGS PROVIDE MEANINGFUL INTERPRETATION OF PREVIOUSLY REPORTED PROGRAMME EFFICACY BY CONTEXTUALIZING PERCEIVED BENEFITS WITHIN PARTICIPANTS' CONSTRUCTED UNDERSTANDING OF CHANGE. SPECIFICALLY, ENVIRONMENTAL, SOCIAL, AND EXPERIENTIAL CONSIDERATIONS HAVE SUGGESTED IMPLICATIONS FOR RESILIENCE BUILDING PROGRAMMES.ABBREVIATIONS: RISE (RESILIENCE, INTEGRATION, SELF-AWARENESS, ENGAGEMENT).	2022	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
9 1756  43 PLASTICITY OF VISUAL ATTENTION IN ISHA YOGA MEDITATION PRACTITIONERS BEFORE AND AFTER A 3-MONTH RETREAT. MEDITATION HAS LATELY RECEIVED CONSIDERABLE INTEREST FROM COGNITIVE NEUROSCIENCE. STUDIES SUGGEST THAT DAILY MEDITATION LEADS TO LONG LASTING ATTENTIONAL AND NEURONAL PLASTICITY. WE PRESENT CHANGES RELATED TO THE ATTENTIONAL SYSTEMS BEFORE AND AFTER A 3 MONTH INTENSIVE MEDITATION RETREAT. WE USED THREE BEHAVIORAL PSYCHOPHYSICAL TESTS - A STROOP TASK, AN ATTENTIONAL BLINK TASK, AND A GLOBAL-LOCAL LETTER TASK-TO ASSESS THE EFFECT OF ISHA YOGA MEDITATION ON ATTENTIONAL RESOURCE ALLOCATION. 82 ISHA YOGA PRACTITIONERS WERE TESTED AT THE BEGINNING AND AT THE END OF THE RETREAT. OUR RESULTS SHOWED AN INCREASE IN CORRECT RESPONSES SPECIFIC TO INCONGRUENT STIMULI IN THE STROOP TASK. CONGRUENTLY, A POSITIVE CORRELATION BETWEEN PREVIOUS MEDITATION EXPERIENCE AND ACCURACY TO INCONGRUENT STROOP STIMULI WAS ALSO OBSERVED AT BASELINE. WE ALSO OBSERVED A REDUCTION OF THE ATTENTIONAL BLINK. UNEXPECTEDLY, A NEGATIVE CORRELATION BETWEEN PREVIOUS MEDITATION EXPERIENCE AND ATTENTIONAL BLINK PERFORMANCE AT BASELINE WAS OBSERVED. REGARDING SPATIAL ATTENTION ORIENTATION AS ASSESSED USING THE GLOBAL-LOCAL LETTER TASK, PARTICIPANTS SHOWED A BIAS TOWARD LOCAL PROCESSING. ONLY SLIGHT DIFFERENCES IN PERFORMANCE WERE FOUND PRE- VS. POST- MEDITATION RETREAT. BIASING TOWARD THE LOCAL STIMULI IN THE GLOBAL-LOCAL TASK AND NEGATIVE CORRELATION OF PREVIOUS MEDITATION EXPERIENCE WITH ATTENTIONAL BLINK PERFORMANCE IS CONSISTENT WITH ISHA PRACTICES BEING FOCUSED-ATTENTION PRACTICES. GIVEN THE RELATIVELY SMALL EFFECT SIZES AND THE ABSENCE OF A CONTROL GROUP, OUR RESULTS DO NOT ALLOW CLEAR SUPPORT NOR REJECTION OF THE HYPOTHESIS OF MEDITATION-DRIVEN NEURONAL PLASTICITY IN THE ATTENTIONAL SYSTEM FOR ISHA YOGA PRACTICE.	2013	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
10  451  46 CHANGES IN FATIGUE, AUTONOMIC FUNCTIONS, AND BLOOD BIOMARKERS DUE TO SITTING ISOMETRIC YOGA IN PATIENTS WITH CHRONIC FATIGUE SYNDROME. BACKGROUND: IN A PREVIOUS RANDOMIZED CONTROLLED TRIAL, WE FOUND THAT SITTING ISOMETRIC YOGA IMPROVES FATIGUE IN PATIENTS WITH CHRONIC FATIGUE SYNDROME (CFS) WHO ARE RESISTANT TO CONVENTIONAL THERAPY. THE AIM OF THIS STUDY WAS TO INVESTIGATE POSSIBLE MECHANISMS BEHIND THIS FINDING, FOCUSING ON THE SHORT-TERM FATIGUE-RELIEVING EFFECT, BY COMPARING AUTONOMIC NERVOUS FUNCTION AND BLOOD BIOMARKERS BEFORE AND AFTER A SESSION OF ISOMETRIC YOGA. METHODS: FIFTEEN PATIENTS WITH CFS WHO REMAINED SYMPTOMATIC DESPITE AT LEAST 6 MONTHS OF CONVENTIONAL THERAPY PRACTICED SITTING ISOMETRIC YOGA (BIWEEKLY 20 MIN PRACTICE WITH A YOGA INSTRUCTOR AND DAILY HOME PRACTICE) FOR EIGHT WEEKS. ACUTE EFFECTS OF SITTING ISOMETRIC YOGA ON FATIGUE, AUTONOMIC FUNCTION, AND BLOOD BIOMARKERS WERE INVESTIGATED AFTER THE FINAL SESSION WITH AN INSTRUCTOR. THE EFFECT OF A SINGLE SESSION OF SITTING ISOMETRIC YOGA ON FATIGUE WAS ASSESSED BY THE PROFILE OF MOOD STATUS (POMS) QUESTIONNAIRE IMMEDIATELY BEFORE AND AFTER THE SESSION. AUTONOMIC NERVOUS FUNCTION (HEART RATE (HR) VARIABILITY) AND BLOOD BIOMARKERS (CORTISOL, DHEA-S, TNF-ALPHA, IL-6, IFN-GAMMA, IFN-ALPHA, PROLACTIN, CARNITINE, TGF-BETA1, BDNF, MHPG, AND HVA) WERE COMPARED BEFORE AND AFTER THE SESSION. RESULTS: SITTING ISOMETRIC YOGA SIGNIFICANTLY REDUCED THE POMS FATIGUE SCORE (P < 0.01) AND INCREASED THE VIGOR SCORE (P < 0.01). IT ALSO REDUCED HR (P < 0.05) AND INCREASED THE HIGH FREQUENCY POWER (P < 0.05) OF HR VARIABILITY. SITTING ISOMETRIC YOGA INCREASED SERUM LEVELS OF DHEA-S (P < 0.05), REDUCED LEVELS OF CORTISOL (P < 0.05) AND TNF-ALPHA (P < 0.05), AND HAD A TENDENCY TO REDUCE SERUM LEVELS OF PROLACTIN (P < 0.1). DECREASES IN FATIGUE SCORES CORRELATED WITH CHANGES IN PLASMA LEVELS OF TGF-BETA1 AND BDNF. IN CONTRAST, INCREASED VIGOR POSITIVELY CORRELATED WITH HVA. CONCLUSIONS: A SINGLE SESSION OF SITTING ISOMETRIC YOGA REDUCED FATIGUE AND INCREASED VIGOR IN PATIENTS WITH CFS. YOGA ALSO INCREASED VAGAL NERVE FUNCTION AND CHANGED BLOOD BIOMARKERS IN A PATTERN THAT SUGGESTED ANTI-STRESS AND ANTI-INFLAMMATORY EFFECTS. THESE CHANGES APPEAR TO BE RELATED TO THE SHORT-TERM FATIGUE-RELIEVING EFFECT OF SITTING ISOMETRIC YOGA IN PATIENTS WITH CFS. FURTHERMORE, DOPAMINERGIC NERVOUS SYSTEM ACTIVATION MIGHT ACCOUNT FOR SITTING ISOMETRIC YOGA-INDUCED INCREASES IN ENERGY IN THIS PATIENT POPULATION. TRIAL REGISTRATION: UNIVERSITY HOSPITAL MEDICAL INFORMATION NETWORK (UMIN CTR) UMIN000009646. REGISTERED DEC 27, 2012.	2018	
                                                                                                                                                  
11 1832  35 PSYCHOLOGICAL WELL-BEING, HEALTH BEHAVIORS, AND WEIGHT LOSS AMONG PARTICIPANTS IN A RESIDENTIAL, KRIPALU YOGA-BASED WEIGHT LOSS PROGRAM. UNLABELLED: THE INCREASING PREVALENCE OF OVERWEIGHT AND OBESITY IN HUMANS IS A GROWING PUBLIC HEALTH CONCERN IN THE UNITED STATES. CONCOMITANTS INCLUDE POOR HEALTH BEHAVIORS AND REDUCED PSYCHOLOGICAL WELL-BEING. PRELIMINARY EVIDENCE SUGGESTS YOGA AND TREATMENT PARADIGMS INCORPORATING MINDFULNESS, SELF-COMPASSION (SC), ACCEPTANCE, NON-DIETING, AND INTUITIVE EATING MAY IMPROVE THESE ANCILLARY CORRELATES, WHICH MAY PROMOTE LONG-TERM WEIGHT LOSS. METHODS: WE EXPLORED THE IMPACT OF A 5-DAY RESIDENTIAL WEIGHT LOSS PROGRAM, WHICH WAS MULTIFACETED AND BASED ON KRIPALU YOGA, ON HEALTH BEHAVIORS, WEIGHT LOSS, AND PSYCHOLOGICAL WELL-BEING IN OVERWEIGHT/OBESE INDIVIDUALS. THIRTY-SEVEN OVERWEIGHT/OBESE PROGRAM PARTICIPANTS (AGE 32-65, BMI<25) COMPLETED VALIDATED MIND-FULNESS, SC, LIFESTYLE BEHAVIOR, AND MOOD QUESTIONNAIRES AT BASELINE, POST-PROGRAM, AND 3-MONTH FOLLOW-UP AND REPORTED THEIR WEIGHT 1 YEAR AFTER PROGRAM COMPLETION. RESULTS: SIGNIFICANT IMPROVEMENTS IN NUTRITION BEHAVIORS, SC, MINDFULNESS, STRESS MANAGEMENT, AND SPIRITUAL GROWTH WERE OBSERVED IMMEDIATELY POST-PROGRAM (N = 31, 84% RETENTION), WITH MEDIUM TO LARGE EFFECT SIZES. AT 3-MONTH FOLLOW-UP (N = 18, 49% RETENTION), MOST CHANGES PERSISTED. PHYSICAL ACTIVITY AND MOOD DISTURBANCE HAD IMPROVED SIGNIFICANTLY POST-PROGRAM BUT FAILED TO REACH SIGNIFICANCE AT 3-MONTH FOLLOW-UP. SELF-REPORT WEIGHT LOSS AT 1 YEAR (N = 19, 51% RETENTION) WAS SIGNIFICANT. CONCLUSION: THESE FINDINGS SUGGEST A KRIPALU YOGA-BASED, RESIDENTIAL WEIGHT LOSS PROGRAM MAY FOSTER PSYCHOLOGICAL WELL-BEING, IMPROVED NUTRITION BEHAVIORS, AND WEIGHT LOSS. GIVEN THE EXPLORATORY NATURE OF THIS INVESTIGATION, MORE RIGOROUS WORK IN THIS AREA IS WARRANTED.	2012	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
12  881  35 EFFECT OF YOGA TRAINING ON INFLAMMATORY CYTOKINES AND C-REACTIVE PROTEIN IN EMPLOYEES OF SMALL-SCALE INDUSTRIES. OBJECTIVE: THE PRESENT STUDY INTENDS TO SEE THE EFFECT OF YOGA PRACTICES ON LIPID PROFILE, INTERLEUKIN (IL)-6, TUMOR NECROSIS FACTOR (TNF)-ALPHA, AND HIGH-SENSITIVITY-C-REACTIVE PROTEIN (HS-CRP) AMONG APPARENTLY HEALTHY ADULTS EXPOSED TO OCCUPATIONAL HAZARDS. MATERIALS AND METHODS: IN THE PRESENT STUDY, 48 PARTICIPANTS AGED 30-58 YEARS (41.5 +/- 5.2) WHO WERE EXPOSED TO OCCUPATIONAL HAZARDS WERE RANDOMIZED INTO TWO GROUPS, THAT IS, EXPERIMENTAL AND WAIT-LIST CONTROL. ALL THE PARTICIPANTS WERE ASSESSED FOR LIPID PROFILE, IL-6, TNF-ALPHA, AND HS-CRP AT THE BASELINE AND AFTER COMPLETION OF 3 MONTHS OF YOGA TRAINING INTERVENTION. THE EXPERIMENTAL GROUP UNDERWENT YOGA TRAINING INTERVENTION FOR 1 H FOR 6 DAYS A WEEK FOR 3 MONTHS, WHEREAS CONTROL GROUP CONTINUED WITH THEIR DAILY ACTIVITIES EXCEPT YOGA TRAINING. DATA ANALYSIS WAS DONE USING STATISTICAL SOFTWARE SPSS VERSION 20.0. DATA WERE ANALYZED USING PAIRED T-TESTS AND INDEPENDENT T-TEST. RESULTS: THE RESULTS OF WITHIN GROUP COMPARISON REVEALED HIGHLY SIGNIFICANT CHANGES IN CHOLESTEROL (P < 0.001), HIGH-DENSITY LIPOPROTEIN (P < 0.001), LOW-DENSITY LIPOPROTEIN (LDL)(P < 0.01), HS-CRP (P < 0.01), IL-6 (P < 0.001), AND TNF-ALPHA (P < 0.001) IN EXPERIMENTAL GROUP. COMPARISON BETWEEN EXPERIMENTAL AND CONTROL GROUP REVEALED SIGNIFICANT CHANGES IN CHOLESTEROL (P < 0.01), LDL (P < 0.05), IL-6 (P < 0.01), TNF-ALPHA (P < 0.01), AND HS-CRP (P < 0.01). CONCLUSION: A YOGA-BASED LIFESTYLE INTERVENTION SEEMS TO BE A HIGHLY PROMISING ALTERNATIVE THERAPY WHICH FAVORABLY ALTERS INFLAMMATORY MARKERS AND METABOLIC RISK FACTORS.	2017	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
13 1211  44 EXPLORING HOW DIFFERENT TYPES OF YOGA CHANGE PSYCHOLOGICAL RESOURCES AND EMOTIONAL WELL-BEING ACROSS A SINGLE SESSION. OBJECTIVES: YOGA DEMONSTRATES BENEFICIAL EFFECTS IN MANY POPULATIONS, YET OUR UNDERSTANDING OF HOW YOGA BRINGS ABOUT THESE EFFECTS IS QUITE LIMITED. AMONG THE PROPOSED MECHANISMS OF YOGA ARE INCREASING PSYCHOLOGICAL RESOURCES (MINDFULNESS, BODY CONSCIOUSNESS, SELF-TRANSCENDENCE, SPIRITUAL PEACE, AND SOCIAL CONNECTEDNESS) THAT MAY BRING ABOUT SALUTARY EFFECTS ON EMOTIONAL WELLBEING. FURTHER, YOGA IS A COMPLEX PRACTICE COMPRISING MEDITATION, ACTIVE AND RESTORATIVE POSTURES, AND BREATHWORK; HOWEVER LITTLE IS KNOWN ABOUT HOW DIFFERENT COMPONENTS MAY AFFECT MECHANISMS. WE AIMED TO DETERMINE HOW AN ACUTE SESSION OF YOGA (AND ITS SPECIFIC COMPONENTS) RELATED TO PRE- TO POST- SESSION CHANGES IN PROPOSED MECHANISMS (PSYCHOLOGICAL RESOURCES) AND WHETHER THOSE CHANGES WERE ASSOCIATED WITH POSITIVE CHANGES IN EMOTIONS. DESIGN: 144 REGULAR YOGA PRACTITIONERS COMPLETED MEASURES OF MINDFULNESS, BODY CONSCIOUSNESS, SELF-TRANSCENDENCE, SOCIAL CONNECTEDNESS, SPIRITUAL PEACE, AND EXERCISE-INDUCED EMOTIONS (POSITIVE ENGAGEMENT, REVITALIZATION, TRANQUILITY, EXHAUSTION) IMMEDIATELY BEFORE AND AFTER A YOGA SESSION (N=11 SESSIONS, EACH A DIFFERENT TYPE OF YOGA). PERCEIVED PROPERTIES OF EACH YOGA SESSION, EXERCISE EXERTION AND ENGAGEMENT WITH THE YOGA TEACHER WERE ASSESSED IMMEDIATELY FOLLOWING THE SESSION. RESULTS: PRE-TO POST- YOGA, LEVELS OF POSITIVE EMOTIONS (ENGAGEMENT, TRANQUILITY AND REVITALIZATION) INCREASED WHILE EXHAUSTION DECREASED. FURTHER, ALL PSYCHOLOGICAL RESOURCES INCREASED AND CLOSELY TRACKED IMPROVED EMOTIONS. ADDITIONALLY, ASPECTS OF THE YOGA SESSION CORRELATED WITH CHANGES IN PSYCHOLOGICAL RESOURCES (MECHANISMS) AND EMOTIONS. CONCLUSIONS: YOGA MAY INFLUENCE MULTIPLE PSYCHOLOGICAL MECHANISMS THAT INFLUENCE EMOTIONAL WELL-BEING. FURTHER, DIFFERENT TYPES OF YOGA MAY AFFECT DIFFERENT MECHANISMS. RESULTS CAN INFORM YOGA INTERVENTIONS AIMING TO OPTIMIZE EFFECTS THROUGH SPECIFIC MECHANISMS SUCH AS MINDFULNESS OR SPIRITUALITY.	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
14 1394  38 IMPACT OF YOGA BASED LIFESTYLE INTERVENTION ON PSYCHOLOGICAL STRESS AND QUALITY OF LIFE IN THE PARENTS OF CHILDREN WITH RETINOBLASTOMA. BACKGROUND: CHILDHOOD CANCERS ARE ASSOCIATED WITH A PSYCHOLOGICAL BURDEN TO THE PARENTS AND HENCE, DECLINE THEIR MENTAL AND PHYSICAL HEALTH AND OVERALL QUALITY OF LIFE. PURPOSE: THE PURPOSE OF THE PRESENT STUDY IS TO INVESTIGATE THE IMPACT OF 12-WEEKS YOGA BASED LIFESTYLE INTERVENTION ON PSYCHOLOGICAL STRESS AND QUALITY OF LIFE IN THE PARENTS OF CHILDREN AFFECTED WITH RETINOBLASTOMA. METHOD: SINGLE ARM PROSPECTIVE CLINICAL TRIAL CONDUCTED FROM OCTOBER 2015 TO OCTOBER 2017 AT THE LABORATORY FOR MOLECULAR REPRODUCTION AND GENETICS, DEPARTMENT OF ANATOMY, ALL INDIA INSTITUTE OF MEDICAL SCIENCES, NEW DELHI, INDIA. A PRE-TESTED 12-WEEKS YOGA BASED LIFESTYLE INTERVENTION INCLUDED ASANAS (PHYSICAL POSTURES), PRANAYAMA (BREATHING EXERCISES), DHYANA (MEDITATION), RELAXATION TECHNIQUES, LECTURES AND FILMS ON YOGA, INTERACTIVE SESSIONS AND INDIVIDUALIZED ADVICE WAS ADMINISTERED TO THE PARTICIPANTS. RESULTS: 12-WEEKS OF YOGA BASED LIFESTYLE INTERVENTION PROGRAMME LEADS TO A SIGNIFICANT IMPROVEMENT IN PSYCHOLOGICAL STRESS AND OVERALL QUALITY OF LIFE IN THE PARENTS OF RETINOBLASTOMA PATIENTS. THERE WAS A SIGNIFICANT IMPROVEMENT IN ALL THE DOMAINS (PHYSICAL HEALTH, PSYCHOLOGICAL HEALTH, SOCIAL RELATIONSHIPS, AND ENVIRONMENT) OF WHOQOL-BREF FROM BASELINE (DAY 0) TO 12-WEEKS OF YOGA BASED LIFESTYLE INTERVENTION. YOGA BASED LIFESTYLE INTERVENTION ALSO LED TO A SIGNIFICANT INCREASE IN THE LEVELS OF BRAIN DERIVED NEUROTROPHIC FACTOR, DEHYDROEPIANDROSTERONE SULPHATE, SIRTUIN 1 AND DECREASED THE CORTISOL AND IL-6 LEVELS. CONCLUSION: YOGA BASED LIFESTYLE INTERVENTION REDUCED THE SEVERITY OF PSYCHOLOGICAL STRESS AND RESULTED IN IMPROVEMENT IN OVERALL QUALITY OF LIFE AND UPREGULATION IN LEVELS OF SYSTEMIC BIOMARKERS OF NEUROPLASTICITY. YBLI MAY SERVE AS A BENEFICIAL THERAPY AND MAY ALSO ACT AS AN EFFECTIVE MEDIUM FOR BETTER STRESS MANAGEMENT TO DEVELOP BETTER COPING STRATEGIES IN THE PARENTS OF RETINOBLASTOMA PATIENTS.	2019	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
15 1641  22 MONITORING THE NEURAL ACTIVITY OF THE STATE OF MENTAL SILENCE WHILE PRACTICING SAHAJA YOGA MEDITATION. OBJECTIVE: TO IDENTIFY THE NEURAL CORRELATES OF THE STATE OF MENTAL SILENCE AS EXPERIENCED THROUGH SAHAJA YOGA MEDITATION. DESIGN: NINETEEN EXPERIENCED MEDITATORS UNDERWENT FUNCTIONAL MAGNETIC RESONANCE IMAGING DURING THREE SHORT CONSECUTIVE MEDITATION PERIODS, CONTRASTED WITH A CONTROL RELAXATION CONDITION. RESULTS: RELATIVE TO BASELINE, AT THE BEGINNING OF THE MEDITATION SESSIONS THERE WAS A SIGNIFICANT INCREASE OF ACTIVATION IN BILATERAL INFERIOR FRONTAL AND TEMPORAL REGIONS. ACTIVATION BECAME PROGRESSIVELY MORE REDUCED WITH DEEPER MEDITATION STAGES AND IN THE LAST MEDITATION SESSION IT BECAME LOCALIZED TO THE RIGHT INFERIOR FRONTAL CORTEX/ RIGHT INSULA AND RIGHT MIDDLE/SUPERIOR TEMPORAL CORTEX. FURTHERMORE, RIGHT INFERIOR FRONTAL ACTIVATION WAS DIRECTLY ASSOCIATED WITH THE SUBJECTIVE DEPTH OF THE MENTAL SILENCE EXPERIENCE. CONCLUSIONS: MEDITATORS APPEAR TO PASS THROUGH AN INITIAL INTENSE NEURAL SELF-CONTROL PROCESS NECESSARY TO SILENCE THEIR MIND. AFTER THIS THEY EXPERIENCE RELATIVELY REDUCED BRAIN ACTIVATION CONCOMITANT WITH THE DEEPENING OF THE STATE OF MENTAL SILENCE OVER RIGHT INFERIOR FRONTAL CORTEX, PROBABLY REFLECTING AN EFFORTLESS PROCESS OF ATTENTIONAL CONTEMPLATION ASSOCIATED WITH THIS STATE.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
16 1789  42 PRELIMINARY INDICATIONS OF THE EFFECT OF A BRIEF YOGA INTERVENTION ON MARKERS OF INFLAMMATION AND DNA METHYLATION IN CHRONICALLY STRESSED WOMEN. YOGA IS ASSOCIATED WITH REDUCED STRESS AND INCREASED WELL-BEING, ALTHOUGH THE MOLECULAR BASIS FOR THESE BENEFITS IS NOT CLEAR. MOUNTING EVIDENCE IMPLICATES THE IMMUNE RESPONSE, WITH CURRENT STUDIES FOCUSED ON PROTEIN IMMUNE MARKERS (SUCH AS CYTOKINES) IN CLINICAL POPULATIONS. TO EXPLORE THE MOLECULAR IMPACT, THIS PILOT STUDY USES A SUBSAMPLE (N=28) FROM A RANDOMISED WAITLIST CONTROL TRIAL INVESTIGATING THE IMPACT OF AN 8-WEEK YOGA INTERVENTION IN A COMMUNITY POPULATION OF WOMEN REPORTING PSYCHOLOGICAL DISTRESS (N=116). WE MEASURED INTERLEUKIN-6 (IL-6), TUMOUR NECROSIS FACTOR (TNF) AND C-REACTIVE PROTEIN (CRP) PROTEIN LEVELS, AND THE DNA METHYLATION OF THESE GENES AND THE GLOBAL INDICATOR, LINE-1. CORRELATIONS BETWEEN THESE AND PSYCHOLOGICAL VARIABLES WERE EXPLORED, IDENTIFYING MODERATE CORRELATIONS WITH CRP PROTEIN LEVELS, AND METHYLATION OF IL-6, CRP AND LINE-1. MANY CYTOKINE SAMPLES WERE BELOW DETECTION, HOWEVER A MANN-WHITNEY U DEMONSTRATED A TREND OF MODERATE BETWEEN-GROUP EFFECT FOR ELEVATED IL-6 IN THE YOGA GROUP. METHYLATION ANALYSES APPLIED CROSS-SECTIONAL AND NON-CONTROLLED LONGITUDINAL ANALYSES. WAIST-TO-HEIGHT RATIO AND AGE WERE COVARIED. WE DEMONSTRATED REDUCED METHYLATION OF THE TNF REGION IN THE YOGA GROUP RELATIVE TO THE WAITLIST CONTROL GROUP. NO OTHER GENES DEMONSTRATED A SIGNIFICANT DIFFERENCE. LONGITUDINAL ANALYSIS FURTHER SUPPORTED THESE RESULTS. THIS STUDY IS ONE OF THE FIRST TO EXPLORE YOGA AND IMMUNOLOGICAL MARKERS IN A NON-CLINICAL POPULATION, AND IS THE FIRST STUDY TO EXPLORE DNA METHYLATION. THESE FINDINGS INDICATE THAT FURTHER RESEARCH INTO MOLECULAR IMPACT OF YOGA ON MARKERS OF IMMUNE FUNCTION IS WARRANTED, WITH LARGER STUDIES REQUIRED.	2016	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
17 1718  37 PERCEIVED STRESS, RESILIENCE, WELL-BEING, AND COVID 19 RESPONSE IN ISHA YOGA PRACTITIONERS COMPARED TO MATCHED CONTROLS: A RESEARCH PROTOCOL. OBJECTIVES: THE COVID-19 PANDEMIC HAS BEEN A SIGNIFICANT STRESSOR WORLDWIDE AND REPORTS OF PSYCHOLOGICAL DISTRESS, DEPRESSION, SEDENTARY LIFESTYLES, AND OVERALL DECREASED WELLBEING ARE INCREASING. YOGA PRACTICES HAVE BEEN FOUND TO IMPROVE MENTAL AND PHYSICAL HEALTH. THE PURPOSE OF THIS RANDOMIZED CONTROLLED TRIAL IS TO COMPARE ISHA YOGA PRACTITIONERS TO CONTROLS ON PERCEIVED STRESS, RESILIENCE, WELLBEING, AND PROTECTION AND RECOVERY FROM COVID-19. TRIAL DESIGN. IN THIS PROSPECTIVE RANDOMIZED CONTROL TRIAL, THE EFFECTS OF YOGA PRACTICES ARE BEING COMPARED BETWEEN SEASONED YOGA PRACTITIONERS WITH TWO CONTROLS WHO ARE AGE (+/-3 YEARS), GENDER MATCHED, AND LIVING IN THE SAME NEIGHBORHOOD. METHODS: PARTICIPANTS WILL BE ASKED TO COMPLETE A SERIES OF WEB-BASED SURVEYS AT BASELINE, SIX WEEKS, AND 12 WEEKS. THESE SURVEYS INCLUDE VALIDATED SCALES AND OBJECTIVE QUESTIONS ON COVID-19 INFECTION AND MEDICAL HISTORY. THE VALIDATED QUESTIONNAIRES ASSESS STRESS, MOOD STATES, RESILIENCE, AND OVERALL WELLBEING. QUESTIONNAIRES, WEEKLY ACTIVITY DIARIES, AND MEDICAL HISTORY, WILL BE COLLECTED USING REDCAP. RESULTS: WE HYPOTHESIZE THAT ROUTINE YOGA PRACTICE DURING THE COVID-19 PANDEMIC WILL REDUCE STRESS, ENHANCE WELL-BEING, AND PROVIDE PROTECTIVE EFFECTS AGAINST COVID-19. CONCLUSION: WITH THE GROWING CONCERN ABOUT THE PHYSICAL AND MENTAL IMPACTS OF COVID-19 AND INCREASED INTEREST IN ALTERNATIVE PRACTICES SUCH AS YOGIC PRACTICES, THIS STUDY WILL CONTRIBUTE TO THE GROWING BODY OF EVIDENCE ABOUT THE SAFETY AND EFFICACY OF YOGA FOR EMOTIONAL, MENTAL, AND PHYSICAL HEALTH CONDITIONS.	2021	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
18 1430  23 IMPROVEMENTS IN PSYCHOLOGICAL HEALTH FOLLOWING A RESIDENTIAL YOGA-BASED PROGRAM FOR FRONTLINE PROFESSIONALS. OBJECTIVE: THE PURPOSE OF THIS PILOT STUDY WAS TO EXAMINE THE EFFECTS OF A RESIDENTIAL YOGA-BASED PROGRAM ON PSYCHOLOGICAL HEALTH AND HEALTH BEHAVIORS IN FRONTLINE PROFESSIONALS. METHODS: FRONTLINE PROFESSIONALS FROM EDUCATION, HEALTH CARE, HUMAN SERVICES, AND CORRECTIONS PARTICIPATED IN THE RISE (RESILIENCE, INTEGRATION, SELF-AWARENESS, ENGAGEMENT) PROGRAM AND COMPLETED QUESTIONNAIRES AT BASELINE, POST-PROGRAM, AND 2 MONTHS FOLLOWING RISE. RESULTS: PAIRED SAMPLES T TESTS REVEALED IMPROVEMENTS IN MINDFULNESS, STRESS, RESILIENCE, AFFECT, AND SLEEP QUALITY FROM BASELINE TO POST-PROGRAM (ALL PS < 0.001, N = 55), WHICH WERE SUSTAINED AT THE 2-MONTH FOLLOW-UP (ALL PS < 0.01, N = 40). PARTICIPANTS ALSO REPORTED INCREASES IN EXERCISE, FRUIT, AND VEGETABLE CONSUMPTION POST-PROGRAM (ALL PS < 0.001), ALL OF WHICH PERSISTED AT THE 2-MONTH FOLLOW-UP (ALL PS < 0.01) EXCEPT EXERCISE. CONCLUSION: THESE FINDINGS SUGGEST THAT RISE IMPROVED INDICES OF PSYCHOLOGICAL HEALTH AND HEALTHY BEHAVIORS THAT REMAINED 2 MONTHS FOLLOWING RISE.	2018	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
19 2250  52 THE LONGITUDINAL EFFECTS OF SEATED ISOMETRIC YOGA ON BLOOD BIOMARKERS, AUTONOMIC FUNCTIONS, AND PSYCHOLOGICAL PARAMETERS OF PATIENTS WITH CHRONIC FATIGUE SYNDROME: A PILOT STUDY. BACKGROUND: IN A PREVIOUS RANDOMIZED CONTROLLED TRIAL, WE FOUND THAT PRACTICING SEATED ISOMETRIC YOGA REGULARLY FOR 2 MONTHS IMPROVED THE FATIGUE OF PATIENTS WITH CHRONIC FATIGUE SYNDROME (CFS) WHO ARE RESISTANT TO CONVENTIONAL THERAPY. THE AIM OF THIS PILOT STUDY WAS TO INVESTIGATE THE POSSIBLE MECHANISMS BEHIND THIS FINDING BY COMPARING BLOOD BIOMARKERS, AUTONOMIC NERVOUS FUNCTION, AND PSYCHOLOGICAL INDICES BEFORE VERSUS AFTER AN INTERVENTION PERIOD OF SEATED ISOMETRIC YOGA PRACTICE. METHODS: FIFTEEN PATIENTS WITH CFS WHO DID NOT SHOW SATISFACTORY IMPROVEMENTS AFTER AT LEAST 6 MONTHS OF CONVENTIONAL THERAPY PRACTICED SEATED ISOMETRIC YOGA (BIWEEKLY 20-MIN SESSIONS WITH A YOGA INSTRUCTOR AND DAILY PRACTICE AT HOME) FOR 2 MONTHS. THE LONGITUDINAL EFFECTS OF SEATED ISOMETRIC YOGA ON FATIGUE, BLOOD BIOMARKERS, AUTONOMIC FUNCTION, AND PSYCHOLOGICAL STATE WERE INVESTIGATED BY COMPARING THE FOLLOWING PARAMETERS BEFORE AND AFTER THE INTERVENTION PERIOD: FATIGUE SEVERITY WAS ASSESSED BY THE CHALDER FATIGUE SCALE (FS) SCORE. LEVELS OF THE BLOOD BIOMARKERS CORTISOL, DHEA-S, TNF-ALPHA, IL-6, PROLACTIN, CARNITINE, TGF-BETA1, BDNF, MHPG, HVA, AND ALPHA-MSH WERE MEASURED. THE AUTONOMIC NERVOUS FUNCTIONS ASSESSED WERE HEART RATE (HR) AND HR VARIABILITY. PSYCHOLOGICAL INDICES INCLUDED THE 20-ITEM TORONTO ALEXITHYMIA SCALE (TAS-20) AND THE HOSPITAL ANXIETY AND DEPRESSION SCALE (HADS). RESULTS: PRACTICING SEATED ISOMETRIC YOGA FOR 2 MONTHS RESULTED IN SIGNIFICANT REDUCTIONS IN THE CHALDER FS (P = 0.002) AND HADS-DEPRESSION (P = 0.02) SCORES. NO SIGNIFICANT CHANGES WERE OBSERVED IN ANY OTHER PARAMETER EVALUATED. THE CHANGE IN CHALDER FS SCORE WAS NOT CORRELATED WITH THE CHANGE IN HADS-DEPRESSION SCORE. HOWEVER, THIS CHANGE WAS POSITIVELY CORRELATED WITH CHANGES IN THE SERUM TNF-ALPHA LEVELS (P = 0.048), THE HIGH FREQUENCY COMPONENT OF HR VARIABILITY (P = 0.042), AND TAS-20 SCORES (P = 0.001). CONCLUSIONS: REGULAR PRACTICE OF SEATED ISOMETRIC YOGA FOR 2 MONTHS REDUCED THE FATIGUE AND DEPRESSIVE SYMPTOM SCORES OF PATIENTS WITH CFS WITHOUT AFFECTING ANY OTHER PARAMETERS WE INVESTIGATED. THIS STUDY FAILED TO IDENTIFY THE MARKERS RESPONSIBLE FOR THE LONGITUDINAL FATIGUE-RELIEVING EFFECT OF SEATED ISOMETRIC YOGA. HOWEVER, CONSIDERING THAT THE REDUCED FATIGUE WAS ASSOCIATED WITH DECREASED SERUM TNF-ALPHA LEVEL AND TAS-20 SCORES, FATIGUE IMPROVEMENT MIGHT BE RELATED TO REDUCED INFLAMMATION AND IMPROVED ALEXITHYMIA IN THESE PATIENTS. TRIAL REGISTRATION: UNIVERSITY HOSPITAL MEDICAL INFORMATION NETWORK (UMIN CTR) UMIN000009646. REGISTERED DEC 27, 2012.	2019	

20  629  40 DIFFERENCES IN BRAIN STRUCTURE AND FUNCTION AMONG YOGA PRACTITIONERS AND CONTROLS. BACKGROUND: YOGA IS A MIND-BODY BASED PHYSICAL ACTIVITY THAT HAS DEMONSTRATED A VARIETY OF PHYSIOLOGICAL, PSYCHOLOGICAL AND COGNITIVE HEALTH BENEFITS. ALTHOUGH YOGA PRACTICE HAS SHOWN TO IMPROVE COGNITIVE PERFORMANCE, FEW STUDIES HAVE EXAMINED THE UNDERLYING NEUROLOGICAL CORRELATES. OBJECTIVE: THE CURRENT STUDY AIMED TO DETERMINE THE DIFFERENCES IN GRAY MATTER VOLUME OF THE HIPPOCAMPUS, THALAMUS AND CAUDATE NUCLEUS AND BRAIN ACTIVATION DURING THE STERNBERG WORKING MEMORY TASK. METHOD: PARTICIPANTS WERE 13 EXPERIENCED YOGA PRACTITIONERS (MEAN AGE = 35.8), DEFINED AS HAVING MORE THAN 3 YEARS OF REGULAR YOGA PRACTICE, AND 13 AGE- AND SEX-MATCHED CONTROLS (MEAN AGE = 35.7). ALL PARTICIPANTS COMPLETED A 6-MIN WALK TEST TO ASSESS FITNESS, PSYCHOSOCIAL AND DEMOGRAPHIC QUESTIONNAIRES; AND UNDERWENT MAGNETIC RESONANCE IMAGING TO ASSESS GRAY MATTER VOLUME AND BRAIN ACTIVATION. RESULTS: THERE WERE NO GROUP DIFFERENCES ON DEMOGRAPHIC MEASURES OF INCOME, EDUCATION AND ON ESTIMATED VO2MAX OR PHYSICAL ACTIVITY LEVELS. GRAY MATTER VOLUME DIFFERENCES WERE OBSERVED IN THE LEFT HIPPOCAMPUS, SHOWING GREATER VOLUME IN EXPERIENCED YOGA PRACTITIONERS COMPARED TO CONTROLS (P = 0.017). THE FUNCTIONAL MRI RESULTS REVEALED LESS ACTIVATION IN THE DORSOLATERAL PREFRONTAL CORTEX IN YOGA PRACTITIONERS COMPARED TO CONTROLS DURING THE ENCODING PHASE OF THE STERNBERG TASK (P < 0.05). REACTION TIME AND ACCURACY ON THE TASK DID NOT DIFFER BETWEEN THE GROUPS. CONCLUSIONS: OUR RESULTS SUGGEST AN ASSOCIATION BETWEEN REGULAR LONG-TERM YOGA PRACTICE AND DIFFERENTIAL STRUCTURE AND FUNCTION OF SPECIFIC BRAIN REGIONS INVOLVED IN EXECUTIVE FUNCTION, SPECIFICALLY WORKING MEMORY, WHICH HAS PREVIOUSLY SHOWN TO IMPROVE WITH YOGA PRACTICE. FUTURE STUDIES NEED TO EXAMINE INTERVENTION EFFECTS OF YOGA AND EXPLORE ITS POTENTIAL TO MAINTAIN AND IMPROVE COGNITIVE HEALTH ACROSS THE LIFESPAN THROUGH LONGITUDINAL AND INTERVENTION STUDIES.	2018