1 138 124 A PRELIMINARY REPORT ON THE ROLE OF YOGA ASANAS ON OXIDATIVE STRESS IN NON-INSULIN DEPENDENT DIABETES MELLITUS. NINETEEN SUBJECTS OF NON-INSULIN DEPENDENT DIABETES MELLITUS (NIDDM) BETWEEN THE AGE GROUP OF 30-60 YRS WERE STUDIED TO SEE THE EFFECT OF SPECIFIC YOGA ASANAS ON FASTING AND POSTPRANDIAL BLOOD GLUCOSE (FBG, PPG), SERUM MALONDIALDEHYDE (MDA) AND GLYCOSYLATED HEMOGLOBIN (HBA(1)) IN ADDITION TO DRUG TREATMENT AND DIET CONTROL. THE DURATION OF DIABETES RANGED FROM 1-10 YEARS. PATIENTS WITH RENAL, CARDIAC AND PROLIFERATIVE RETINAL DISEASES WERE EXCLUDED FROM THE STUDY. THE SAME PATIENTS SERVED AS THEIR OWN CONTROL. SUBJECTS WERE CALLED IN THE MORNING TO THE CARDIO-RESPIRATORY LABORATORY AND WERE GIVEN TRAINING BY A YOGA EXPERT. YOGA ASANAS INCLUDED SURYANAMSKAR, TADASAN, TRIKONASAN, PADMASAN, PRANAYAM, PASCHIMOTTANASAN, ARDHMATSYENDRASAN, PAVANMUKTHASAN, SARPASAN AND SHAVASAN. THE ASANAS WERE DONE EVERY DAY FOR 40 DAYS FOR 30-40 MIN. FBG, PPG, SERUM MDA AND HBA(1) WERE ESTIMATED BEFORE AND AFTER 40 DAYS OF YOGA ASANAS REGIMEN. SIGNIFICANT REDUCTION WAS SEEN IN FBG FROM 220 MG/DL TO 162 MG/DL, PPG FROM 311 MG/DL TO 255 MG/DL, MDA FROM 6 NMOL/L TO 3 NMOL/L AND HBA(1), FROM 8.8% TO 6.4%. SUBJECTS FELT BETTER AND WERE RELIEVED OF THEIR STRESSES AND HAD AN IMPROVEMENT IN THEIR DAY TO DAY PERFORMANCE. THE DECREASE WAS STATISTICALLY SIGNIFICANT (P<0.0001 FOR FBG AND PPG, P<0.001 FOR MDA AND FOR HBA(1)). 2001 2 2356 12 VALSALVA HAEMORRHAGIC RETINOPATHY IN PREGNANCY AFTER YOGA. A 35-YEAR-OLD PREGNANT CAUCASIAN WOMAN AT 27 WEEKS GESTATION PRESENTED WITH SUDDEN ONSET PAINLESS LOSS OF VISION AND A LARGE FLOATER IN HER LEFT EYE WHILE DOING YOGA. SHE WAS FOUND TO HAVE A DENSE VITREOUS HAEMORRHAGE WITH A SMALL PRERETINAL HAEMORRHAGE. ULTRASOUND IMAGING CONFIRMED THE HAEMORRHAGE AND SHOWED NO OTHER RETINAL DAMAGE. SHE WAS DIAGNOSED WITH VALSALVA HAEMORRHAGIC RETINOPATHY AND WAS TREATED CONSERVATIVELY. AFTER 5 MONTHS OF FOLLOW-UP, THIS WOMAN HAD HAD A NORMAL DELIVERY AND HER HAEMORRHAGES AND VISION LOSS HAD RESOLVED. 2017 3 781 61 EFFECT OF YOGA ASANAS ON NERVE CONDUCTION IN TYPE 2 DIABETES. TWENTY TYPE 2 DIABETIC SUBJECTS BETWEEN THE AGE GROUP OF 30-60 YEARS WERE STUDIED TO SEE THE EFFECT OF 40 DAYS OF YOGA ASANAS ON THE NERVE CONDUCTION VELOCITY. THE DURATION OF DIABETES RANGED FROM 0-10 YEARS. SUBJECT SUFFERING FROM CARDIAC, RENAL AND PROLIFERATIVE RETINAL COMPLICATIONS WERE EXCLUDED FROM THE STUDY YOGA ASANAS INCLUDED SURYANAMSKAR. TADASAN, KONASAN, PADMASAN PRANAYAM, PASCHIMOTTANSAN ARDHMATSYENDRASAN, SHAVASAN, PAVANMUKTHASAN, SARPASAN AND SHAVASAN. SUBJECTS WERE CALLED TO THE CARDIO-RESPIRATORY LABORATORY IN THE MORNING TIME AND WERE GIVEN TRAINING BY THE YOGA EXPERT. THE YOGA EXERCISES WERE PERFORMED FOR 30-40 MINUTES EVERY DAY FOR 40 DAYS IN THE ABOVE SEQUENCE. THE SUBJECTS WERE PRESCRIBED CERTAIN MEDICINES AND DIET. THE BASAL BLOOD GLUCOSE, NERVE CONDUCTION VELOCITY OF THE MEDIAN NERVE WAS MEASURED AND REPEATED AFTER 40 DAYS OF YOGIC REGIME. ANOTHER GROUP OF 20 TYPE 2 DIABETES SUBJECTS OF COMPARABLE AGE AND SEVERITY, CALLED THE CONTROL GROUP, WERE KEPT ON PRESCRIBED MEDICATION AND LIGHT PHYSICAL EXERCISES LIKE WALKING. THEIR BASAL & POST 40 DAYS PARAMETERS WERE RECORDED FOR COMPARISON. RIGHT HAND AND LEFT HAND MEDIAN NERVE CONDUCTION VELOCITY INCREASED FROM 52.81 +/- 1.1 M/SEC TO 53.87 +/- 1.1 M/SEC AND 52.46 +/- 1.0 TO 54.75 +/- 1/1 M/SEC RESPECTIVELY. CONTROL GROUP NERVE FUNCTION PARAMETERS DETERIORATED OVER THE PERIOD OF STUDY, INDICATING THAT DIABETES IS A SLOWLY PROGRESSIVE DISEASE INVOLVING THE NERVES. YOGA ASANAS HAVE A BENEFICIAL EFFECT ON GLYCAEMIC CONTROL AND IMPROVE NERVE FUNCTION IN MILD TO MODERATE TYPE 2 DIABETES WITH SUB-CLINICAL NEUROPATHY. 2002 4 379 15 BASILAR ARTERY OCCLUSION FOLLOWING YOGA EXERCISE: A CASE REPORT. BASILAR ARTERY OCCLUSION DEVELOPED IN A 34 YEAR OLD WOMAN 2 MONTHS AFTER ADOPTING UNUSUAL NECK POSTURES DURING YOGA PRACTICE. ON ANGIOGRAPHY, HER BASILAR ARTERY WAS FILLED WITH INTRALUMINAL CLOT WHILE THE VERTEBRAL ARTERIES WERE NORMAL. WE POSTULATE THAT A SEVERE REDUCTION IN BLOOD FLOW AND POSSIBLY AN INTIMAL TEAR TRIGGERED THROMBOSIS OF THE VERTEBRAL ARTERY AND THAT THE FINAL STROKE MECHANISM WAS ARTERY-TO-ARTERY EMBOLISM. 1993 5 2056 48 THE BENEFICIAL EFFECT OF YOGA IN DIABETES. TWENTY NIDDM SUBJECTS (MILD TO MODERATE DIABETICS) IN THE AGE GROUP OF 30-60 YEARS WERE SELECTED FROM THE OUT PATIENT CLINIC OF G.T.B. HOSPITAL. THEY WERE ON A 40 DAYS YOGA ASANA REGIME UNDER THE SUPERVISION OF A YOGA EXPERT. 13 SPECIFIC YOGA ASANAS < OR = DONE BY TYPE 2 DIABETES PATIENTS INCLUDED. SURYA NAMASKAR, TRIKONASANA, TADASANA, SUKHASANA, PADMASANA, BHASTRIKA PRANAYAMA, PASHIMOTTANASANA, ARDHMATSYENDRASANA, PAWANMUKTASANA, BHUJANGASANA, VAJRASANA, DHANURASANA AND SHAVASANA ARE BENEFICIAL FOR DIABETES MELLITUS. SERUM INSULIN, PLASMA FASTING AND ONE HOUR POSTPRANDIAL BLOOD GLUCOSE LEVELS AND ANTHROPOMETRIC PARAMETERS WERE MEASURED BEFORE AND AFTER YOGA ASANAS. THE RESULTS INDICATE THAT THERE WAS SIGNIFICANT DECREASE IN FASTING GLUCOSE LEVELS FROM BASAL 208.3 +/- 20.0 TO 171.7 +/- 19.5 MG/DL AND ONE HOUR POSTPRANDIAL BLOOD GLUCOSE LEVELS DECREASED FROM 295.3 +/- 22.0 TO 269.7 +/- 19.9 MG/DL. THE EXACT MECHANISM AS TO HOW THESE POSTURES AND CONTROLLED BREATHING INTERACT WITH SOMATOENDOCRINE MECHANISM AFFECTING INSULIN KINETICS WAS WORKED OUT. A SIGNIFICANT DECREASE IN WAIST-HIP RATIO AND CHANGES IN INSULIN LEVELS WERE ALSO OBSERVED, SUGGESTING A POSITIVE EFFECT OF YOGA ASANAS ON GLUCOSE UTILISATION AND FAT REDISTRIBUTION IN NIDDM. YOGA ASANAS MAY BE USED AS AN ADJUNCT WITH DIET AND DRUGS IN THE MANAGEMENT OF TYPE 2 DIABETES. 2005 6 2874 11 YOGA-INDUCED UVEITIS GLAUCOMA HYPHEMA SYNDROME. A 74-YEAR-OLD PSEUDOPHAKIC WHITE WOMAN WITH PSEUDOEXFOLIATION SYNDROME PRESENTED WITH RIGHT EYE PAIN AND PHOTOPHOBIA AND WAS FOUND TO HAVE PSEUDOPHACODENESIS WITH RECURRENT EPISODES OF ANTERIOR UVEITIS, MICROHYPHEMA, AND ELEVATED INTRAOCULAR PRESSURE (IOP). ALL EPISODES OCCURRED AFTER YOGA SESSIONS WITH INTENSIVE FACEDOWN POSTURES. ULTRASOUND BIOMICROSCOPY (UBM) PERFORMED IN SUPINE AND PRONE POSITIONS DEMONSTRATED SIGNIFICANT CHANGE IN THE LENS-BAG COMPLEX POSITION, WITH LENS-IRIS TOUCH. THE PATIENT UNDERWENT INTRAOCULAR LENS (IOL) EXPLANTATION, ANTERIOR VITRECTOMY, AND FLANGED INTRASCLERAL HAPTIC-FIXATED IOL PLACEMENT VIA DOUBLE-NEEDLE TECHNIQUE, WITH RESOLUTION OF ALL SYMPTOMS. 2021 7 1736 18 PHOTO URTICARIA CAUSED BY EXPOSURE TO LED EMITTING 633-NM WAVELENGTH DURING HOT YOGA EXERCISE. PHOTO URTICARIA (PU) IS A RARE TYPE OF URTICARIA THAT DEVELOPS AFTER EXPOSURE TO VARIOUS WAVELENGTHS OF LIGHT. INDUCING URTICARIAL WHEALS USING LIGHT SOURCES OF PERTINENT WAVELENGTHS CAN HELP MAKE THE DEFINITIVE DIAGNOSIS OF PU. THE ACTION SPECTRA (AS) IN JAPANESE PATIENTS WITH PU COMMONLY FALL WITHIN THE ULTRAVIOLET RADIATION A AND VISIBLE LIGHT RANGE. HEREIN, TO THE BEST OF OUR KNOWLEDGE, WE PRESENT THE FIRST CASE OF PU CAUSED BY 633-NM WAVELENGTH WITHIN THE VISIBLE LIGHT SPECTRUM. OUR PATIENT WORKED AS A "HOT YOGA" INSTRUCTOR, WHERE LIGHT-EMITTING DIODES (LEDS) ON THE CEILING WERE USED TO IRRADIATE THE ENTIRE ROOM WITH 633-NM WAVELENGTH OF LIGHT FOR "LIGHT TREATMENT." SHE REPORTED ITCHING AND WHEALS ON THE FACE AND NECK DURING HER "HOT YOGA" SESSIONS. "HOT YOGA" HAS RECENTLY GAINED POPULARITY GLOBALLY. THE "LIGHT TREATMENT" IS BASED ON THE THEORY THAT 633-NM WAVELENGTH LIGHT WITHIN THE VISIBLE LIGHT SPECTRUM REPORTEDLY PREVENTS THE SKIN FROM AGING. WE INDUCED WHEALS WITH ERYTHEMA BY IRRADIATING HER SKIN USING A 633-NM LED AT A DOSE OF 0.008 J/CM(2) /S FOR 1 H. HER CONDITION WAS DIAGNOSED AS PU CAUSED BY EXPOSURE TO 633 NM. LIGHT. HER SYMPTOMS HAVE NOT RECURRED SINCE SHE HAS AVOIDED BEING EXPOSED TO THE 633-NM WAVELENGTH OF LED LIGHT. 2021 8 1775 10 PRACTICE OF YOGA MAY CAUSE DAMAGE OF BOTH SCIATIC NERVES: A CASE REPORT. SCIATIC NERVE TRAUMATIC DAMAGE VERY RARELY OCCURS BILATERALLY. WE DESCRIBE THE CASE OF A 67-YEAR-OLD WOMAN WHO REPORTED A BILATERAL TRAUMATIC LESION OF THE SCIATIC NERVE DURING PRACTICE OF YOGA. NERVE CONDUCTION STUDIES SHOWED A BILATERAL SCIATIC NERVE NEUROPATHY, MOSTLY AFFECTING THE PERONEAL COMPONENT. LUMBAR PLEXUS MRI DOCUMENTED REGULAR ANATOMICAL FEATURES OF THE MAIN PRINCIPAL NERVE ROOTS WITH BILATERAL T2 SIGNAL ALTERATION OF ROOTS L4, L5 AND S1 THAT EXTENDED INTO THE SCIATIC NERVES SHOWING BOTH INCREASE IN SIZE, PROBABLY RELATED TO CHRONIC INJURY OF NERVES, AND AN ALTERATION IN DIFFUSION SIGNAL THAT SUGGESTED A RECENT ACUTE OVERLAPPED PROCESS. 2013 9 2694 12 YOGA INDUCED ACUTE ULNAR NERVE COMPRESSION BY A GANGLION CYST IN GUYON'S CANAL. ACUTE ULNAR NEUROPATHY AT THE WRIST CAN BE DIFFICULT TO DIAGNOSE, AS IT IS AN UNCOMMON NEUROPATHY WITH VARIABLE CLINICAL PRESENTATIONS AND NUMEROUS ETIOLOGIES. WE PRESENT A CASE OF ACUTE ULNAR NEUROPATHY OF THE DEEP MOTOR BRANCH CAUSED BY A GANGLION CYST IN GUYON'S CANAL. INTERESTINGLY, THIS CASE OF ACUTE LOSS OF MOTOR FUNCTION OCCURRED AFTER THE PATIENT PARTICIPATED IN YOGA (SPECIFICALLY THE DOWNWARD DOG POSITION), AND RESOLVED SPONTANEOUSLY OVER TIME AFTER STOPPING YOGA, WITHOUT SURGICAL EXCISION OF THE GANGLION, SUGGESTING EXACERBATION OR PROTRUSION OF AN OCCULT GANGLION CYST DUE TO INCREASED ACTIVITY AND COMPRESSION OF THE HYPOTHENAR EMINENCE. 2013 10 42 14 A CASE OF RECTUS SHEATH HEMATOMA CAUSED BY YOGA EXERCISE. RECTUS SHEATH HEMATOMA IS A RELATIVELY RARE CONDITION BUT A SIGNIFICANT CAUSE OF ACUTE ABDOMINAL PAIN. THE ACUTE ABDOMINAL PAIN ASSOCIATED WITH RECTUS SHEATH HEMATOMA CAN MIMIC SEVERAL CONDITIONS, SUCH AS APPENDICITIS, INTESTINAL PROBLEMS (OBSTRUCTION, PERFORATION, HERNIA, MALIGNANCY), AND GYNECOLOGIC DISEASE (OVARIAN CYST, TORSION, TUBO-OVARIAN ABSCESS, ECTOPIC PREGNANCY). CORRECT DIAGNOSIS AND SUBSEQUENT TREATMENT DEPENDS ON CAREFUL HISTORY TAKING AND APPROPRIATE USE OF DIAGNOSTIC TOOLS TO AVOID UNNECESSARY LAPAROTOMY. WE REPORT A CASE OF RECTUS SHEATH HEMATOMA DUE TO NONCONTACT STRENUOUS EXERCISE, YOGA, THAT MIMICKED GYNECOLOGIC DISEASES. 2009 11 49 19 A COMPARATIVE CLINICAL STUDY OF SHATAPATRAYADI CHURNA TABLET AND PATOLADI YOGA IN THE MANAGEMENT OF AMLAPITTA. AMLAPITTA IS A VERY COMMON DISEASE CAUSED BY VIDAGDHA PITTA WITH FEATURES SUCH AS AMLODGARA, HRID KANTHA DAHA, AND AVIPAKA. THIS IS A BURNING PROBLEM OF THE SOCIETY. IRREGULAR AND IMPROPER FOOD HABITS, AND BUSY STRESSFUL LIFESTYLE IS ONE OF THE MAIN CULPRIT. AMLAPITTA IS THE GI DISORDER DESCRIBED IN AYURVEDIC TEXTS THAT CLOSELY RESEMBLES WITH GASTRITIS IN MODERN SCIENCE. IN CHRONIC STAGE, IT MAY LEAD TO ULCERATIVE CONDITIONS. IN THIS STUDY, TOTAL 41 PATIENTS WERE REGISTERED AND WERE RANDOMLY DIVIDED INTO TWO GROUPS. IN GROUP A, SHATAPATRAYADICHURNA TABLET AND IN GROUP B PATOLADI YOGA TABLET WERE GIVEN FOR 1 MONTH. THE NIDANA, SIGNS, AND SYMPTOMS WERE OBSERVED CAREFULLY TO GET IDEA ABOUT THE SAMPRAPTI OF THE DISEASE. THE EFFECT OF PATOLADI YOGA ON ROGA BALA IS 65.79%, 62.11% ON AGNI BALA, AND 63.35% ON DEHA AND CHETASA BALA. THE OVERALL RELIEF WAS 63.75%. THE EFFECT OF SHATAPATRAYADI TABLET ON ROGA BALA WAS 71.94%, 73.15% ON AGNI BALA, AND 77.68% ON DEHA AND CHETAS BALA. THE OVERALL RELIEF WAS 74.25%. 2011 12 2289 12 THE YOGA OF RAG GTPASES: DYNAMIC STRUCTURAL POSES CONFER AMINO ACID SENSING BY MTORC1. HETERODIMERIC RAG GTPASES PLAY A CRITICAL ROLE IN RELAYING FLUCTUATING LEVELS OF CELLULAR AMINO ACIDS TO THE SENSOR MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1. IMPORTANT MECHANISTIC QUESTIONS REMAIN UNRESOLVED, HOWEVER, REGARDING HOW GUANINE NUCLEOTIDE BINDING ENABLES RAG GTPASES TO TRANSITION DYNAMICALLY BETWEEN DISTINCT YOGA-LIKE STRUCTURAL POSES THAT CONTROL ACTIVATION STATE. EGRI AND SHEN IDENTIFIED A CRITICAL INTERDOMAIN HYDROGEN BOND WITHIN RAGA AND RAGC THAT STABILIZES THEIR GDP-BOUND STATES. THEY DEMONSTRATE THAT THIS LONG-DISTANCE INTERACTION CONTROLS RAG STRUCTURE AND FUNCTION TO CONFER APPROPRIATE AMINO ACID SENSING BY MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1. 2021 13 52 18 A COMPARATIVE STUDY OF BILVADI YOGA ASHCHYOTANA AND EYE DROPS IN VATAJA ABHISHYANDA (SIMPLE ALLERGIC CONJUNCTIVITIS). SIMPLE ALLERGIC CONJUNCTIVITIS IS THE MOST COMMON FORM OF OCULAR ALLERGY (PREVALENCE 5 - 22 %). IT IS A HYPERSENSITIVITY REACTION TO SPECIFIC AIRBORNE ANTIGENS. THE DISEASE VATAJA ABHISHYANDA, WHICH IS DUE TO VITIATION OF VATA PRADHANA TRIDOSHA IS COMPARABLE WITH THIS CONDITION. THE MANAGEMENT OF SIMPLE ALLERGIC CONJUNCTIVITIS IN MODERN OPHTHALMOLOGY IS VERY EXPENSIVE AND IT SHOULD BE FOLLOWED LIFELONG AND AYURVEDA CAN PROVIDE BETTER RELIEF IN SUCH MANIFESTATION. THIS IS THE FIRST RESEARCH STUDY ON VATAJA ABHISHYANDA. PATIENTS WERE SELECTED FROM THE OUTPATIENT DEPARTMENT (OPD), INPATIENT DEPARTMENT (IPD), OF THE SHALAKYA TANTRA DEPARTMENT AND WERE RANDOMLY DIVIDED INTO TWO GROUPS. IN GROUP-A BILVADI ASHCHYOTANA AND IN GROUP-B BILVADI EYE DROPS WERE INSTILLED FOR THREE MONTHS. TOTAL 32 PATIENTS WERE REGISTERED AND 27 PATIENTS COMPLETED THE COURSE OF TREATMENT. BILVADI ASHCHYOTANA GAVE BETTER RESULTS IN TODA, SANGHARSHA, PARUSHYA, KANDU AND RAGATA AS COMPARED WITH BILVADI EYE DROPS IN VATAJA ABHISHYANDA. 2012 14 1763 16 POSTERIOR VITREOUS DETACHMENT PRECIPITATED BY YOGA. YOGA HAS RECENTLY BEEN TOUTED AS A MEANS TO IMPROVE PHYSICAL AND MENTAL WELL-BEING. HOWEVER, NO FORM OF EXERCISE IS WITHOUT ITS RISKS. A 32-YEAR-OLD CHINESE FEMALE WITH MODERATE MYOPIA COMPLAINED OF RIGHT EYE SUDDEN ONSET OF FLOATERS AND MILD BLURRING OF VISION AFTER THE HEAD-DOWN POSTURE. THE VISUAL ACUITY WAS 6/12 IN THE RIGHT EYE AND 6/9 IN THE LEFT EYE. A RIGHT EYE FUNDUS EXAMINATION SHOWED POSTERIOR VITREOUS DETACHMENT, WITH A SMALL BLOOD CLOT LOCATED AT THE INFERIOR MARGIN OF THE OPTIC DISC. THE PATIENT WAS DIAGNOSED WITH RIGHT EYE VITREOUS HEMORRHAGE SECONDARY TO ACUTE POSTERIOR VITREOUS DETACHMENT AND WAS MANAGED CONSERVATIVELY. ACUTE CHANGES IN POSTURE, ESPECIALLY BETWEEN AN UPRIGHT AND A HEAD-DOWN POSITION, MAY CAUSE ACUTE POSTERIOR VITREOUS DETACHMENT. AS YOGA PRACTITIONERS MAY BE REQUIRED TO ASSUME THIS HEAD-DOWN POSITION, MYOPIC PATIENTS SHOULD BE WARNED OF THE POSSIBLE OCULAR COMPLICATIONS OF THIS EXERCISE. 2018 15 1358 22 IMMEDIATE EFFECT OF YOGA EXERCISES FOR EYES ON THE MACULAR THICKNESS. BACKGROUND: YOGA EXERCISES FOR EYES HAVE BEEN ADVOCATED AS BENEFICIAL TO EYE HEALTH. IN A PREVIOUS STUDY, WE EVALUATED THE EFFECT OF YOGA EXERCISES FOR EYES ON THE INTRAOCULAR PRESSURE (IOP). THE OTHER ASPECTS OF THE EFFECTS OF YOGA EXERCISES FOR EYES TO OCULAR STRUCTURE HAVE NOT BEEN INVESTIGATED YET. AIM: THE AIM OF THIS STUDY IS TO EVALUATE THE EFFECT OF YOGA EXERCISES FOR EYES ON THE MACULAR STRUCTURE USING THE OPTICAL COHERENCE TOMOGRAPHY (OCT) AND OCT ANGIOGRAPHY (OCTA) PARAMETERS. METHODS: TWENTY-NINE PARTICIPANTS WERE INCLUDED IN THIS MASKED WITHIN PARTICIPANT COMPARISON OF HEALTHY CONTROLS. BASIC OPHTHALMIC EXAMINATION WAS PERFORMED, AFTER WHICH PATIENTS WERE EVALUATED FOR IOP, OCT, AND OCTA BEFORE AND AFTER YOGA EXERCISES FOR EYES. OCT/A PARAMETERS THAT WERE EVALUATED WERE: AVERAGE MACULAR THICKNESS (AMT) (MUM), CENTRAL MACULAR THICKNESS (MUM), CENTRAL CHOROIDAL THICKNESS (MUM) VESSEL DENSITY (%) IN THE SUPERFICIAL, DEEP VASCULAR LAYERS, AND IN THE CHORIOCAPILLARIS. RESULTS: IOP WAS SIGNIFICANTLY REDUCED (POSTEXERCISE IOP = 13.02 MMHG +/- 2.82 MMHG) FROM THE INITIAL VALUE (PREEXERCISE IOP = 13.86 MMHG +/- 2.85 MMHG, P = 0.02). AMT SIGNIFICANTLY INCREASED (POSTEXERCISE AMT = 275.40 MUM +/- 10.85 MUM) FROM THE PREEXERCISE MEASUREMENT (PREEXERCISE AMT = 274.41 MUM +/- 10.89 MUM; P = 0.02). CONCLUSION: AFTER YOGA OCULAR EXERCISES, IOP SIGNIFICANTLY DECREASED AND AMT SIGNIFICANTLY INCREASED IN HEALTHY CONTROLS, SUGGESTING AN EFFECT OF THESE EXERCISES ON THE MACULAR THICKNESS. 2020 16 1656 11 MUSCULOSKELETAL INJURIES RELATED TO YOGA: IMAGING OBSERVATIONS. OBJECTIVE: THE PURPOSE OF THIS ARTICLE IS TO DESCRIBE THE IMAGING APPEARANCES OF MUSCULOSKELETAL INJURIES RELATED TO YOGA. WE PERFORMED AN AUTOMATED SEARCH IN THE DATABASE OF A LARGE TERTIARY CARE CENTER AND CONDUCTED A RETROSPECTIVE ANALYSIS OF THE IMAGING FINDINGS IN 38 PATIENTS OVER A 9-YEAR PERIOD. CONCLUSION: THE MOST FREQUENTLY ENCOUNTERED MUSCULOSKELETAL INJURIES WERE TENDINOUS LESIONS, INCLUDING TEARS OF THE SUPRASPINATUS, ACHILLES, AND PERONEUS BREVIS TENDONS AND FIBROCARTILAGINOUS TEARS INVOLVING THE MEDIAL MENISCUS, ACETABULAR LABRUM, GLENOID LABRUM, AND LUMBAR DISK WITH EXTRUSION. 2012 17 1819 13 PROTEIN YOGA: CONFORMATIONAL VERSATILITY OF THE HEMOLYSIN II C-TERMINAL DOMAIN DETAILED BY NMR STRUCTURES FOR MULTIPLE STATES. THE C-TERMINAL DOMAIN OF BACILLUS CEREUS HEMOLYSIN II (HLYIIC), STABILIZES THE TRANS-MEMBRANE-PORE FORMED BY THE HLYII TOXIN AND MAY AID IN TARGET CELL RECOGNITION. INITIAL EFFORTS TO DETERMINE THE NMR STRUCTURE OF HLYIIC WERE HAMPERED BY CIS/TRANS ISOMERIZATION ABOUT THE SINGLE PROLINE AT POSITION 405 THAT LEADS TO DOUBLING OF NMR RESONANCES. WE USED THE MUTANT P405M-HLYIIC THAT ELIMINATES THE CIS PROLINE TO DETERMINE THE NMR STRUCTURE OF THE DOMAIN, WHICH REVEALED A NOVEL FOLD. HERE, WE EXTEND EARLIER STUDIES TO THE NMR STRUCTURE DETERMINATION OF THE CIS AND TRANS STATES OF WT-HLYIIC THAT EXIST SIMULTANEOUSLY IN SOLUTION. THE PRIMARY STRUCTURAL DIFFERENCES BETWEEN THE CIS AND TRANS STATES ARE IN THE LOOP THAT CONTAINS P405, AND STRUCTURALLY ADJACENT LOOPS. THERMODYNAMIC LINKAGE ANALYSIS SHOWS THAT AT 25 C THE CIS PROLINE, WHICH ALREADY HAS A LARGE FRACTION OF 20% IN THE UNFOLDED PROTEIN, INCREASES TO 50% IN THE FOLDED STATE DUE TO COUPLING WITH THE GLOBAL STABILITY OF THE DOMAIN. THE P405M OR P405A SUBSTITUTIONS ELIMINATE HETEROGENEITY DUE TO PROLINE ISOMERIZATION BUT LEAD TO THE FORMATION OF A NEW DIMERIC SPECIES. THE NMR STRUCTURE OF THE DIMER SHOWS THAT IT IS FORMED THROUGH DOMAIN-SWAPPING OF STRAND BETA5, THE LAST SEGMENT OF SECONDARY STRUCTURE FOLLOWING P405. THE PRESENCE OF P405 IN WT-HLYIIC STRONGLY DISFAVORS THE DIMER COMPARED TO THE P405M-HLYIIC OR P405A-HLYIIC MUTANTS. THE WT PROLINE MAY THUS ACT AS A "GATEKEEPER," WARDING OFF AGGREGATIVE MISFOLDING. 2021 18 1265 14 FLEXIBILITY-NOT JUST FOR YOGA ANYMORE! OVER THE PAST FEW YEARS, NUCLEOSIDES HAVE MAINTAINED A PROMINENT ROLE AS ONE OF THE CORNERSTONES OF ANTIVIRAL AND ANTICANCER THERAPEUTICS, AND MANY APPROACHES TO NUCLEOSIDE DRUG DESIGN HAVE BEEN PURSUED. ONE SUCH APPROACH INVOLVES FLEXIBILITY IN THE SUGAR MOIETY OF NUCLEOSIDES, FOR EXAMPLE, IN THE HIGHLY SUCCESSFUL ANTI-HIV AND HBV DRUG TENOFOVIR. IN CONTRAST, INTRODUCTION OF FLEXIBILITY TO THE NUCLEOBASE SCAFFOLD HAS ONLY MORE RECENTLY GAINED SIGNIFICANCE WITH THE INVENTION OF OUR FLEXIMERS. THE HISTORY, DEVELOPMENT, AND SOME BIOLOGICAL RELEVANCE FOR THIS INNOVATIVE CLASS OF NUCLEOSIDES ARE DETAILED HEREIN. 2018 19 482 23 CLINICAL EFFICACY OF HERBAL PADMAPATRADI YOGA IN BRONCHIAL ASTHMA (TAMAKA SWASA). AYURVEDA REFERS TO BRONCHIAL ASTHMA AS TAMAKA SWASA AND IT IS WELL EXPLAINED IN CHARAKA SAMHITA. IT CONTRIBUTES SEVERAL MODALITIES OF THE TREATMENT FOR SWASA ROGA(ASTHMA). AMONG ALL MODALITIES OF TREATMENT, POLYHERBAL COMBINATIONS ARE SAID TO BE WELL-ACCEPTED, SAFE AND EFFECTIVE IN ASTHMA. A STUDY WAS CARRIED OUT IN 40 PATIENTS OF EITHER SEX IN BETWEEN THE AGE OF 15-65 YEARS TO ASSURE THE CLINICAL RESPONSE OF PADMAPATRADI YOGA IN BRONCHIAL ASTHMA (TAMAKA SWASA) AT P.G. DEPARTMENT OF KAYACHIKITSA, D.G.M. AYURVEDIC MEDICAL COLLEGE, GADAG, KARNATAKA. THE SUM TOTAL PROPERTIES OF PADMAPATRADI YOGA IS TIKTA KATU RASA, LAGHU AND TIKNA GUNA (LIGHT AND PENETRATING PROPERTIES), USHNA VIRYA (HOT POTENCY) AND VATAKAPHAGNA (DECREASE VATA AND KAPHA DOSA) PADMAPATRADI YOGA IS EFFECTIVE IN INCREASED PEAK EXPIRATORY FLOW RATE, BREATH HOLDING TIME, AND REDUCES THE ABSOLUTE EOSINOPHIL COUNT OF STUDIED CASES AND ALSO FOUND STATISTICALLY HIGHLY SIGNIFICANT AT P<0.001 LEVEL. THE DRUG IS QUITE SAFE AND ACTS AS A BRONCHODILATOR, ANTIHISTAMINIC AND ANTI-INFLAMMATORY. 2011 20 481 20 CLINICAL EFFICACY OF APAMARGA KSHARA YOGA IN THE MANAGEMENT OF SHVITRA (VITILIGO). INTRODUCTION: VITILIGO IS A PROGRESSIVE, IDIOPATHIC, PIGMENTATION DISORDER OF THE SKIN, CHARACTERIZED BY HYPOPIGMENTED PATCHES. THIS CONDITION IS COMPARED WITH SHVITRA IN AYURVEDA. MANY AYURVEDIC DRUGS ARE BENEFICIAL IN SUCH CASES AND APAMARGA KSHARA YOGA IS ONE AMONG THEM. AIM: TO EVALUATE THE EFFICACY OF APAMARGA KSHARA YOGA IN LEPA AND OINTMENT FORMS IN THE MANAGEMENT OF SHVITRA. MATERIALS AND METHODS: TOTAL 50 PATIENTS OF SHVITRA WERE RANDOMLY GROUPED INTO TWO. PATIENTS REGISTERED IN GROUP A (N = 25) WERE TREATED WITH APAMARGA KSHARA YOGA LEPA AND GROUP B (N = 25) WITH APAMARGA KSHARA YOGA OINTMENT FOR 2 MONTHS. RASAYANA CHURNA (3G) ALONG WITH HONEY AND GHEE WAS GIVEN TWICE DAILY INTERNALLY IN THE BOTH GROUPS. RESULTS: SIGNIFICANT IMPROVEMENT WAS FOUND IN THE SYMPTOMS OF SHVITRA WITH TREATMENT IN BOTH THE GROUPS. THE DIFFERENCE IN BETWEEN THE GROUPS WAS STATISTICALLY INSIGNIFICANT. CONCLUSION: BOTH FORMS OF APAMRAGA KSHARA YOGA ARE EFFECTIVE IN CASES OF SHVITRA AND CAN BE GOOD ALTERNATIVES FOR CONTEMPORARY MEDICINES. 2015