1 1374 159 IMPACT OF AN INTEGRATED YOGA THERAPY PROTOCOL ON INSULIN RESISTANCE AND GLYCEMIC CONTROL IN PATIENTS WITH TYPE 2 DIABETES MELLITUS. OBJECTIVE: DIABETES MELLITUS (DM), CHARACTERIZED BY CHRONIC HYPERGLYCEMIA, IS ATTRIBUTED TO RELATIVE INSULIN DEFICIENCY OR RESISTANCE, OR BOTH. STUDIES HAVE SHOWN THAT YOGA CAN MODULATE PARAMETERS OF INSULIN RESISTANCE. THE PRESENT STUDY EXPLORED THE POSSIBLE BENEFICIAL EFFECTS OF INTEGRATED YOGA THERAPY WITH REFERENCE TO GLYCEMIC CONTROL AND INSULIN RESISTANCE (IR) IN INDIVIDUALS WITH DIABETES MAINTAINED ON STANDARD ORAL MEDICAL CARE WITH YOGA THERAPY, COMPARED TO THOSE ON STANDARD ORAL MEDICAL CARE ALONE. METHODS: IN THIS STUDY, THE SUBJECTS ON YOGA INTERVENTION COMPRISED 35 TYPE 2 DIABETICS, AND AN EQUAL NUMBER OF VOLUNTEERS CONSTITUTED THE CONTROL GROUP. SUBJECTS RANGED IN AGE FROM 30 TO 70 YEARS, WITH HEMOGLOBIN A1C (HBA1C) TEST MORE THAN 7%, AND WERE MAINTAINED ON DIABETIC DIET AND ORAL HYPOGLYCEMIC AGENTS. BLOOD SAMPLES WERE DRAWN PRIOR TO AND AFTER 120 DAYS OF INTEGRATED YOGA THERAPY INTERVENTION. FASTING BLOOD GLUCOSE (FBG), POST-PRANDIAL BLOOD GLUCOSE (PPBG), HBA1C, INSULIN, AND LIPID PROFILE WERE ASSESSED IN BOTH THE INTERVENTION AND CONTROL GROUPS. RESULTS: THE INTERVENTION GROUP REVEALED SIGNIFICANT IMPROVEMENTS IN BODY MASS INDEX (BMI) (0.7 KG/M(2) MEDIAN DECREASE; P=0.001), FBG (20 MG/DL MEDIAN DECREASE; P<0.001), PPBG (33 MG/DL MEDIAN DECREASE; P<0.001), HBA1C (0.4% MEDIAN DECREASE; P<0.001), HOMEOSTATIC MODEL ASSESSMENT FOR INSULIN RESISTANCE (HOMA-IR) (1.2 MEDIAN DECREASE; P<0.001), CHOLESTEROL (13 MG/DL MEDIAN DECREASE, P=0.006), TRIACYLGLYCEROL (22 MG/DL MEDIAN DECREASE; P=0.027), LOW-DENSITY LIPOPROTEIN (6 MG/DL MEDIAN DECREASE; P=0.004), AND VERY-LOW-DENSITY LIPOPROTEIN LEVELS (4 MG/DL MEDIAN DECREASE; P=0.032). INCREASES IN HIGH-DENSITY LIPOPROTEIN AFTER 120 DAYS WERE NOT SIGNIFICANT (6 MG/DL MEDIAN INCREASE; P=0.15). HOWEVER, WHEN COMPARED TO CHANGES OBSERVED IN PATIENTS IN THE CONTROL GROUP, ALL THESE IMPROVEMENTS PROVED TO BE SIGNIFICANT. CONCLUSION: ADMINISTRATION OF INTEGRATED YOGA THERAPY TO INDIVIDUALS WITH DIABETES LEADS TO A SIGNIFICANT IMPROVEMENT IN GLYCEMIC CONTROL, INSULIN RESISTANCE, AND KEY BIOCHEMICAL PARAMETERS.	2022	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
2  812  40 EFFECT OF YOGA ON CARDIAC AUTONOMIC DYSFUNCTION AND INSULIN RESISTANCE IN NON-DIABETIC OFFSPRING OF TYPE-2-DIABETES PARENTS: A RANDOMIZED CONTROLLED STUDY. OBJECTIVE: THE PRESENT STUDY WAS AIMED TO DETERMINE THE EFFECT OF YOGA PROGRAM ON CARDIAC AUTONOMIC DYSFUNCTION AND INSULIN RESISTANCE IN NON-DIABETIC OFFSPRING OF DIABETES PARENTS. METHODS: A RANDOMIZED PASSIVE-CONTROLLED STUDY WAS CONDUCTED ON 64 NON-DIABETIC OFFSPRING OF TYPE-2-DIABETES PARENTS (MEAN-AGE:25.17YEARS). YOGA GROUP PARTICIPANTS RECEIVED YOGA TRAINING FOR 8 WEEKS. HEART-RATE VARIABILITY (HRV) INDICES: LOW FREQUENCY (LF), HIGH FREQUENCY (HF) AND LF/HF RATIO; FASTING BLOOD GLUCOSE (FBG), ORAL GLUCOSE TOLERANCE TEST (OGTT) AND INSULIN RESISTANCE (IR) WERE ESTIMATED AT BASELINE AND AFTER 8-WEEKS OF INTERVENTION. RESULTS: WE FOUND A SIGNIFICANT DECREASE IN LF (P=0.005), LF/HF RATIO (P=0.004), IR (P<0.001), OGTT (P=0.003) AND INCREASE IN HF (P=0.022) IN YOGA GROUP PARTICIPANTS. CONTROL GROUP PARTICIPANTS DID NOT SHOW ANY SIGNIFICANT CHANGE IN ANY VARIABLES. CONCLUSIONS: IMPROVEMENT IN CARDIAC AUTONOMIC FUNCTION AND INSULIN RESISTANCE BY YOGA TRAINING IMPLIES THAT YOGA CAN REDUCE THE RISK OF DEVELOPMENT OF DIABETES IN OFFSPRING OF DIABETES PARENTS.	2019	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
3 2816  53 YOGA TRAINING IMPROVES METABOLIC PARAMETERS IN OBESE BOYS. YOGA HAS BEEN KNOWN TO HAVE STIMULATORY OR INHIBITORY EFFECTS ON THE METABOLIC PARAMETERS AND TO BE UNCOMPLICATED THERAPY FOR OBESITY. THE PURPOSE OF THE PRESENT STUDY WAS TO TEST THE EFFECT OF AN 8-WEEK OF YOGA-ASANA TRAINING ON BODY COMPOSITION, LIPID PROFILE, AND INSULIN RESISTANCE (IR) IN OBESE ADOLESCENT BOYS. TWENTY VOLUNTEERS WITH BODY MASS INDEX (BMI) GREATER THAN THE 95TH PERCENTILE WERE RANDOMLY ASSIGNED TO YOGA (AGE 14.7+/-0.5 YEARS, N=10) AND CONTROL GROUPS (AGE 14.6+/-1.0 YEARS, N=10). THE YOGA GROUP PERFORMED EXERCISES THREE TIMES PER WEEK AT 40~60% OF HEART-RATE RESERVE (HRR) FOR 8 WEEKS. IR WAS DETERMINED WITH THE HOMEOSTASIS MODEL ASSESSMENT OF INSULIN RESISTANCE (HOMA-IR). AFTER YOGA TRAINING, BODY WEIGHT, BMI, FAT MASS (FM), AND BODY FAT % (BF %) WERE SIGNIFICANTLY DECREASED, AND FAT-FREE MASS AND BASAL METABOLIC RATE WERE SIGNIFICANTLY INCREASED THAN BASELINE VALUES. FM AND BF % WERE SIGNIFICANTLY IMPROVED IN THE YOGA GROUP COMPARED WITH THE CONTROL GROUP (P<0.05). TOTAL CHOLESTEROL (TC) WAS SIGNIFICANTLY DECREASED IN THE YOGA GROUP (P<0.01). HDL-CHOLESTEROL WAS DECREASED IN BOTH GROUPS (P<0.05). NO SIGNIFICANT CHANGES WERE OBSERVED BETWEEN OR WITHIN GROUPS FOR TRIGLYCERIDES, LDL-CHOLESTEROL, GLUCOSE, INSULIN, AND HOMA-IR. OUR FINDINGS SHOW THAT AN 8-WEEK OF YOGA TRAINING IMPROVES BODY COMPOSITION AND TC LEVELS IN OBESE ADOLESCENT BOYS, SUGGESTING THAT YOGA TRAINING MAY BE EFFECTIVE IN CONTROLLING SOME METABOLIC SYNDROME FACTORS IN OBESE ADOLESCENT BOYS.	2012	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
4  324  42 ANTHROPOMETRIC, BIOCHEMICAL AND CLINICAL PARAMETERS IN CLIMACTERIC YOGA PRACTITIONERS. OBJECTIVE: THIS STUDY AIMED TO EVALUATE ANTHROPOMETRIC, BIOCHEMICAL AND CLINICAL PARAMETERS IN CLIMACTERIC YOGA PRACTITIONERS. METHODS: THIS STUDY INVESTIGATED 108 CLIMACTERIC WOMEN. WE RECRUITED 28 WOMEN BETWEEN 40 AND 65 YEARS OLD WHO STARTED YOGA PRACTICES IN PREMENOPAUSE AND HAD ALREADY PRACTICED FOR AT LEAST 5 YEARS. AS CONTROLS, WE SELECTED 30 PHYSICAL ACTIVITY (PA) PRACTITIONERS WHO HAD PRACTICED FOR AT LEAST 5 YEARS AND 50 SEDENTARY WOMEN IN THE SAME AGE RANGE. WE CONDUCED ANTHROPOMETRIC, BIOCHEMICAL AND BLOOD PRESSURE MEASUREMENTS. RESULTS: THE YOGA GROUP HAD SIGNIFICANTLY LOWER FASTING BLOOD GLUCOSE THAN THE PA PRACTITIONERS AND SEDENTARY WOMEN. YOGA PRACTITIONERS ALSO HAD LOWER WEIGHT, BODY MASS INDEX, WAIST CIRCUMFERENCE, BODY FAT PERCENTAGE AND WAIST-TO-HEIGHT RATIO; HIGHER LEVELS OF HIGH-DENSITY LIPOPROTEIN CHOLESTEROL; LOWER LEVELS OF TRIGLYCERIDES, INSULIN, HOMEOSTASIS MODEL ASSESSMENT OF INSULIN RESISTANCE, URIC ACID, APOLIPOPROTEIN B AND HIGH-SENSITIVITY C-REACTIVE PROTEIN; AND LOWER FREQUENCY OF METABOLIC SYNDROME, LIPID ACCUMULATION PRODUCT, VISCERAL ADIPOSITY INDEX AND SYSTOLIC BLOOD PRESSURE THAN THE SEDENTARY WOMEN. CONCLUSION: YOGA PRACTITIONERS HAD LOWER GLUCOSE SERUM CONCENTRATIONS THAN THE PA PRACTITIONERS AND SEDENTARY WOMEN. OVERALL, THE YOGA GROUP ALSO HAD BETTER ANTHROPOMETRIC, BIOCHEMICAL AND CLINICAL VARIABLES THAN THE OTHER GROUPS. ALTHOUGH FURTHER INVESTIGATION IS REQUIRED, YOGA PRACTICE IN PREMENOPAUSE SEEMS TO BE BENEFICIAL FOR WOMEN WHEN THEY REACH MENOPAUSE.	2022	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
5  679  46 EFFECT OF A YOGA PROGRAM ON GLUCOSE METABOLISM AND BLOOD LIPID LEVELS IN ADOLESCENT GIRLS WITH POLYCYSTIC OVARY SYNDROME. OBJECTIVE: TO ASSESS THE EFFICACY OF YOGA THERAPY ON GLUCOSE METABOLISM AND BLOOD LIPID VALUES IN ADOLESCENT GIRLS WITH POLYCYSTIC OVARY SYNDROME (PCOS). METHODS: A PROSPECTIVE, RANDOMIZED, INTERVENTIONAL CONTROLLED TRIAL RECRUITED 90 ADOLESCENTS AGED BETWEEN 15 AND 18 YEARS WHO MET THE ROTTERDAM CRITERIA FOR PCOS. A YOGA GROUP PRACTICED SURYANAMASKARA, ASANAS, PRANAYAMA, AND MEDITATION 1 HOUR PER DAY EACH DAY FOR 12 WEEKS WHILE ANOTHER GROUP PRACTICED CONVENTIONAL PHYSICAL EXERCISES. THE MANN-WHITNEY U TEST WAS USED TO COMPARE SCORE CHANGES BETWEEN THE 2 GROUPS. RESULTS: THE CHANGES IN FASTING INSULIN, FASTING BLOOD GLUCOSE, AND HOMEOSTASIS MODEL ASSESSMENT OF INSULIN RESISTANCE WERE SIGNIFICANTLY DIFFERENT IN THE 2 GROUPS (P<0.05). EXCEPT FOR HIGH-DENSITY LIPOPROTEIN CHOLESTEROL, THE CHANGES IN BLOOD LIPID VALUES WERE ALSO SIGNIFICANTLY DIFFERENT (P<0.05). THE CHANGES IN BODY MASS INDEX, WAIST CIRCUMFERENCE, HIP CIRCUMFERENCE, AND WAIST-TO-HIP RATIO, HOWEVER, WERE NOT SIGNIFICANTLY DIFFERENT (P>0.05). CONCLUSION: YOGA WAS FOUND TO BE MORE EFFECTIVE THAN CONVENTIONAL PHYSICAL EXERCISES IN IMPROVING GLUCOSE, LIPID, AND INSULIN VALUES, INCLUDING INSULIN RESISTANCE VALUES, IN ADOLESCENT GIRLS WITH PCOS INDEPENDENT OF ANTHROPOMETRIC CHANGES. CENTRAL TRIAL REGISTRY OF INDIA NO.: REFCTRI-2008 000291.	2012	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
6 1030  47 EFFECTS OF YOGA EXERCISE ON SERUM ADIPONECTIN AND METABOLIC SYNDROME FACTORS IN OBESE POSTMENOPAUSAL WOMEN. OBJECTIVE: REGULAR AND CONTINUOUS YOGA EXERCISE IS ONE OF THE MOST IMPORTANT NONPHARMACOLOGICAL METHODS OF IMPROVING SERUM LIPID CONCENTRATIONS, ADIPOSE TISSUE, AND METABOLIC SYNDROME FACTORS. THE PURPOSE OF THIS STUDY WAS TO ANALYZE THE EFFECTS OF YOGA EXERCISE ON SERUM ADIPONECTIN AND METABOLIC SYNDROME FACTORS IN OBESE POSTMENOPAUSAL KOREAN WOMEN. METHODS: SIXTEEN HEALTHY POSTMENOPAUSAL WOMEN AGED 54.50 +/- 2.75 YEARS WITH MORE THAN 36% BODY FAT WERE RANDOMLY ASSIGNED TO EITHER A YOGA EXERCISE GROUP (N = 8) OR TO A "NO EXERCISE" CONTROL GROUP (N = 8). THE VARIABLES OF BODY COMPOSITION, VISCERAL FAT, SERUM ADIPONECTIN, AND METABOLIC SYNDROME FACTORS WERE MEASURED IN ALL THE PARTICIPANTS BEFORE AND AFTER THE 16-WEEK STUDY. RESULTS: BODY WEIGHT, PERCENTAGE OF BODY FAT, LEAN BODY MASS, BODY MASS INDEX, WAIST CIRCUMFERENCE, AND VISCERAL FAT AREA HAD SIGNIFICANTLY DECREASED. HIGH-DENSITY LIPOPROTEIN CHOLESTEROL AND ADIPONECTIN HAD SIGNIFICANTLY INCREASED, BUT TOTAL CHOLESTEROL, TRIGLYCERIDE, LOW-DENSITY LIPOPROTEIN CHOLESTEROL, BLOOD PRESSURE, INSULIN, GLUCOSE, AND HOMOEOSTASIS MODEL ASSESSMENT-INSULIN RESISTANCE HAD SIGNIFICANTLY DECREASED. SERUM ADIPONECTIN CONCENTRATIONS WERE SIGNIFICANTLY CORRELATED WITH WAIST CIRCUMFERENCE, HIGH-DENSITY LIPOPROTEIN CHOLESTEROL, DIASTOLIC BLOOD PRESSURE, AND HOMOEOSTASIS MODEL ASSESSMENT-INSULIN RESISTANCE IN THE POSTYOGA EXERCISE GROUP. CONCLUSIONS: OUR FINDINGS INDICATE THAT YOGA EXERCISE IMPROVES ADIPONECTIN LEVEL, SERUM LIPIDS, AND METABOLIC SYNDROME RISK FACTORS IN OBESE POSTMENOPAUSAL WOMEN. CONSEQUENTLY, YOGA EXERCISE WILL BE EFFECTIVE IN PREVENTING CARDIOVASCULAR DISEASE CAUSED BY OBESITY IN OBESE POSTMENOPAUSAL KOREAN WOMEN.	2012	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
7 1453  45 INFLUENCE OF PRANAYAMAS AND YOGA-ASANAS ON SERUM INSULIN, BLOOD GLUCOSE AND LIPID PROFILE IN TYPE 2 DIABETES. A DISTINGUISHABLE FEATURE OF TYPE 2 DIABETES BESIDES HYPERGLYCEMIA AND DERANGED LIPID PROFILE IS AN IMPAIRED INSULIN SECRETION, PERIPHERAL INSULIN RESISTANCE AND OBESITY WHICH HAS BECOME A MAJOR HEALTH CONCERN WORLDWIDE. INDIA WITH AN ESTIMATED 31MILLION DIABETICS IN 2000 AND 79MLLIONS BY THE YR 2030 HAS THE HIGHEST NUMBER OF TYPE 2 DIABETICS IN THE WORLD. IN THIS STUDY, WE AIMED TO SEE IF YOGA-ASANAS AND PRANAYAMAS HAVE ANY INFLUENCE IN MODIFYING CERTAIN BIOCHEMICAL PARAMETERS. SIXTY PATIENTS OF UNCOMPLICATED TYPE 2 DIABETES (AGE 35-60 YRS OF 1-10 YRS DURATION) WERE DIVIDED INTO TWO GROUPS: GROUP 1 (N=30): PERFORMED YOGA ALONG WITH THE CONVENTIONAL HYPOGLYCEMIC MEDICINES AND GROUP 2 (N=30): PATIENTS WHO ONLY RECEIVED CONVENTIONAL MEDICINES. DURATION OF THE STUDY WAS 45 DAYS. BASAL RECORDINGS OF BLOOD GLUCOSE (FASTING AND POST-PRANDIAL), LIPID PROFILE AND SERUM INSULIN WERE TAKEN AT THE TIME OF RECRUITMENT AND THE SECOND READING AFTER FORTY FIVE DAYS. RESULTS SHOWED A SIGNIFICANT IMPROVEMENT IN ALL THE BIOCHEMICAL PARAMETERS IN GROUP 1 WHILE GROUP 2 SHOWED SIGNIFICANT IMPROVEMENT IN ONLY FEW PARAMETERS, THUS SUGGESTING A BENEFICIAL EFFECT OF YOGA REGIMEN ON THESE PARAMETERS IN DIABETIC PATIENTS.	2008	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
8  451  41 CHANGES IN FATIGUE, AUTONOMIC FUNCTIONS, AND BLOOD BIOMARKERS DUE TO SITTING ISOMETRIC YOGA IN PATIENTS WITH CHRONIC FATIGUE SYNDROME. BACKGROUND: IN A PREVIOUS RANDOMIZED CONTROLLED TRIAL, WE FOUND THAT SITTING ISOMETRIC YOGA IMPROVES FATIGUE IN PATIENTS WITH CHRONIC FATIGUE SYNDROME (CFS) WHO ARE RESISTANT TO CONVENTIONAL THERAPY. THE AIM OF THIS STUDY WAS TO INVESTIGATE POSSIBLE MECHANISMS BEHIND THIS FINDING, FOCUSING ON THE SHORT-TERM FATIGUE-RELIEVING EFFECT, BY COMPARING AUTONOMIC NERVOUS FUNCTION AND BLOOD BIOMARKERS BEFORE AND AFTER A SESSION OF ISOMETRIC YOGA. METHODS: FIFTEEN PATIENTS WITH CFS WHO REMAINED SYMPTOMATIC DESPITE AT LEAST 6 MONTHS OF CONVENTIONAL THERAPY PRACTICED SITTING ISOMETRIC YOGA (BIWEEKLY 20 MIN PRACTICE WITH A YOGA INSTRUCTOR AND DAILY HOME PRACTICE) FOR EIGHT WEEKS. ACUTE EFFECTS OF SITTING ISOMETRIC YOGA ON FATIGUE, AUTONOMIC FUNCTION, AND BLOOD BIOMARKERS WERE INVESTIGATED AFTER THE FINAL SESSION WITH AN INSTRUCTOR. THE EFFECT OF A SINGLE SESSION OF SITTING ISOMETRIC YOGA ON FATIGUE WAS ASSESSED BY THE PROFILE OF MOOD STATUS (POMS) QUESTIONNAIRE IMMEDIATELY BEFORE AND AFTER THE SESSION. AUTONOMIC NERVOUS FUNCTION (HEART RATE (HR) VARIABILITY) AND BLOOD BIOMARKERS (CORTISOL, DHEA-S, TNF-ALPHA, IL-6, IFN-GAMMA, IFN-ALPHA, PROLACTIN, CARNITINE, TGF-BETA1, BDNF, MHPG, AND HVA) WERE COMPARED BEFORE AND AFTER THE SESSION. RESULTS: SITTING ISOMETRIC YOGA SIGNIFICANTLY REDUCED THE POMS FATIGUE SCORE (P < 0.01) AND INCREASED THE VIGOR SCORE (P < 0.01). IT ALSO REDUCED HR (P < 0.05) AND INCREASED THE HIGH FREQUENCY POWER (P < 0.05) OF HR VARIABILITY. SITTING ISOMETRIC YOGA INCREASED SERUM LEVELS OF DHEA-S (P < 0.05), REDUCED LEVELS OF CORTISOL (P < 0.05) AND TNF-ALPHA (P < 0.05), AND HAD A TENDENCY TO REDUCE SERUM LEVELS OF PROLACTIN (P < 0.1). DECREASES IN FATIGUE SCORES CORRELATED WITH CHANGES IN PLASMA LEVELS OF TGF-BETA1 AND BDNF. IN CONTRAST, INCREASED VIGOR POSITIVELY CORRELATED WITH HVA. CONCLUSIONS: A SINGLE SESSION OF SITTING ISOMETRIC YOGA REDUCED FATIGUE AND INCREASED VIGOR IN PATIENTS WITH CFS. YOGA ALSO INCREASED VAGAL NERVE FUNCTION AND CHANGED BLOOD BIOMARKERS IN A PATTERN THAT SUGGESTED ANTI-STRESS AND ANTI-INFLAMMATORY EFFECTS. THESE CHANGES APPEAR TO BE RELATED TO THE SHORT-TERM FATIGUE-RELIEVING EFFECT OF SITTING ISOMETRIC YOGA IN PATIENTS WITH CFS. FURTHERMORE, DOPAMINERGIC NERVOUS SYSTEM ACTIVATION MIGHT ACCOUNT FOR SITTING ISOMETRIC YOGA-INDUCED INCREASES IN ENERGY IN THIS PATIENT POPULATION. TRIAL REGISTRATION: UNIVERSITY HOSPITAL MEDICAL INFORMATION NETWORK (UMIN CTR) UMIN000009646. REGISTERED DEC 27, 2012.	2018	
                                                                                                                                                                                                                                                                                                                             
9  435  43 CARDIOPULMONARY AND METABOLIC EFFECTS OF YOGA IN HEALTHY VOLUNTEERS. BACKGROUND: YOGA THE SPIRITUAL UNION OF MIND WITH THE DIVINE INTELLIGENCE OF THE UNIVERSE AIMS TO LIBERATE A HUMAN BEING FROM CONFLICTS OF BODY-MIND DUALITY. BENEFICIAL CARDIOVASCULAR AND PULMONARY EFFECTS OF YOGA ARE IN PAR WITH AEROBIC EXERCISE, EVEN AMOUNTING TO REPLACE THE EXERCISE MODEL. WE CONDUCTED AN INTERVENTIONAL STUDY IN HEALTHY VOLUNTEERS, TO ANALYZE THE IMPACT OF SHORT-TERM YOGA TRAINING ON CARDIOVASCULAR, PULMONARY, AUTONOMIC FUNCTION TESTS, LIPID PROFILE, AND THYROID FUNCTION TESTS. MATERIALS AND METHODS: A SAMPLE OF FIFTY NEW RECRUITS ATTENDING THE DISTRICT YOGA CENTER WAS SUBJECT TO 75 MIN YOGA PRACTICE A DAY FOR 41 DAYS. BASAL VALUES OF CARDIOVASCULAR, PULMONARY, AUTONOMIC FUNCTION TESTS, LIPID PROFILE, AND THYROID FUNCTION TESTS WERE RECORDED BEFORE YOGA TRAINING AND WERE REASSESSED FOR POSTYOGA CHANGES AFTER 41 DAYS. RESULTS: AFTER YOGA PRACTICE THERE WAS A SIGNIFICANT REDUCTION IN THE RESTING HEART RATE, SYSTOLIC BLOOD PRESSURE, DIASTOLIC BLOOD PRESSURE, AND MEAN BLOOD PRESSURE OF THE PARTICIPANTS. EFFECTS ON AUTONOMIC FUNCTION TESTS WERE VARIABLE AND INCONCLUSIVE. THERE WAS A SIGNIFICANT INCREASE IN FORCED VITAL CAPACITY, FORCED EXPIRATORY VOLUME IN 1 S, AND PEAK EXPIRATORY FLOW RATE AFTER YOGA. A SIGNIFICANT REDUCTION IN BODY MASS INDEX WAS OBSERVED. EFFECTS ON METABOLIC PARAMETERS WERE PROMISING WITH A SIGNIFICANT REDUCTION IN FASTING BLOOD SUGAR LEVEL, SERUM TOTAL CHOLESTEROL, SERUM TRIGLYCERIDES SERUM LOW-DENSITY LIPOPROTEIN LEVELS, AND SIGNIFICANT INCREASE IN HIGH-DENSITY LIPOPROTEIN. THERE WAS NO SIGNIFICANT CHANGE IN THYROID FUNCTION TESTS AFTER YOGA. CONCLUSION: SHORT-TERM YOGA PRACTICE HAS NO EFFECT ON THYROID FUNCTIONS. YOGA PRACTICE WAS FOUND BENEFICIAL IN MAINTAINING PHYSIOLOGICAL MILIEU PERTAINING TO CARDIOVASCULAR AND OTHER METABOLIC PARAMETERS.	2017	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
10  939  55 EFFECTS OF 12 WEEKS PRACTICE OF YOGA ON HEART RATE VARIABILITY IN MALES WITH TYPE 2 DIABETES RECEIVING ORAL ANTIDIABETIC DRUGS: A RANDOMIZED CONTROL TRIAL. OBJECTIVE: TO INVESTIGATE THE EFFECTS OF 12 WEEKS PRACTICE OF A STRUCTURED YOGA MODULE ON HEART RATE VARIABILITY (HRV) AND CARDIOMETABOLIC RISKS IN PATIENTS WITH TYPE 2 DIABETES (T2D) RECEIVING SIMILAR KIND OF ORAL ANTIDIABETIC DRUGS (OAD) WITH YOGA THERAPY AND WITHOUT YOGA THERAPY, MATCHED FOR ALL THE KNOWN CONFOUNDERS. DESIGN: PARALLEL DESIGN INTERVENTIONAL (RANDOMIZED CONTROL TRIAL) STUDY. SUBJECTS: EIGHTY TREATMENT-NAIVE MALES WITH T2D WERE RANDOMIZED INTO CONTROL GROUP (N = 40) AND STUDY GROUP (N = 40). INTERVENTION: STUDY GROUP PARTICIPANTS RECEIVED A STRUCTURED YOGA THERAPY THAT INCLUDED ASANA AND PRANAYAMA PRACTICE FOR 12 WEEKS IN ADDITION TO OAD, WHEREAS CONTROL GROUP PARTICIPANTS RECEIVED OAD ALONE. OUTCOME MEASURES: BEFORE AND AFTER INTERVENTION, BP PARAMETERS, RATE PRESSURE PRODUCT (RPP) AS THE MARKER OF MYOCARDIAL STRESS, TOTAL POWER (TP) OF HRV, LOW-FREQUENCY TO HIGH-FREQUENCY (LF-HF) RATIO OF HRV, HOMEOSTATIC MODEL OF INSULIN RESISTANCE (HOMA-IR), LIPID PROFILE AND LIPID RISK FACTORS, MALONDIALDEHYDE (MDA), AND HIGH-SENSITIVE C-REACTIVE PROTEIN (HSCRP) WERE MEASURED. TP OF HRV WAS DEFINED AS THE PRIMARY OUTCOME. ASSOCIATION OF TP (THE MARKER OF HRV) AND LF-HF RATIO (THE MARKER OF SYMPATHOVAGAL BALANCE) WITH CARDIOMETABOLIC PARAMETERS WAS ASSESSED BY CORRELATION AND REGRESSION ANALYSES. RESULTS: AFTER 12 WEEKS YOGA THERAPY, THERE WAS SIGNIFICANT REDUCTION IN CARDIOMETABOLIC RISKS (TP OF HRV, RPP, LIPID RISKS FACTORS, LEVELS OF MDA, AND HSCRP) IN STUDY GROUP SUBJECTS COMPARED WITH CONTROL SUBJECTS THAT DID NOT RECEIVE YOGA THERAPY. ALL CARDIOMETABOLIC RISK FACTORS WERE SIGNIFICANTLY CORRELATED WITH TP IN STUDY GROUP, HAVING MAXIMUM SIGNIFICANCE WITH HOMEOSTATIC MODEL OF INSULIN SECRETION (R = 0.502, P </= 0.001). MULTIPLE REGRESSION ANALYSIS DEMONSTRATED THE INDEPENDENT CONTRIBUTION OF DECREASE IN RPP, HOMA-IR, HSCRP, AND MDA TO INCREASED TP AND DECREASED LF-HF RATIO IN T2D PATIENTS AFTER YOGA THERAPY. CONCLUSION: FROM THE RESULTS OF THIS STUDY, THE AUTHORS CONCLUDE THAT 12 WEEKS PRACTICE OF A STRUCTURED YOGA MODULE IMPROVES TP OF HRV, SYMPATHOVAGAL BALANCE, AND METABOLIC FUNCTIONS, AND REDUCE CARDIOVASCULAR (CV) RISKS IN PATIENTS WITH DIABETES WHO RECEIVED ROUTINE ANTIDIABETIC MEDICINES ALONG WITH YOGA THERAPY, COMPARED WITH THE PATIENTS WITH DIABETES WHO RECEIVED ANTIDIABETIC MEDICINES ALONE. THE REDUCTION IN CARDIOMETABOLIC RISKS IN THESE PATIENTS IS LINKED TO THE IMPROVEMENT IN TP OF HRV. FUTURE STUDIES SHOULD ALSO INCLUDE A CONTROL GROUP WITH RAPID WALKING OR A SIMILAR EXERCISE PROGRAM OF EQUAL TIME TO THE YOGA INTERVENTION GROUP TO DISCERN WHETHER IT IS IN FACT YOGA THAT IS LEADING TO THESE RESULTS AND NOT SIMPLY INCREASED CV ACTIVITY. CLINICAL TRIAL REGISTRY OF INDIA (NO. CTRI/2021/06/034074).	2021	

11  692  40 EFFECT OF COMMUNITY-BASED YOGA INTERVENTION ON OXIDATIVE STRESS AND GLYCEMIC PARAMETERS IN PREDIABETES: A RANDOMIZED CONTROLLED TRIAL. OBJECTIVES: TO STUDY THE EFFECTIVENESS OF YOGA INTERVENTION ON OXIDATIVE STRESS, GLYCEMIC STATUS, BLOOD PRESSURE AND ANTHROPOMETRY IN PREDIABETES. DESIGN: RANDOMIZED-CONTROLLED TRIAL. PARTICIPANTS: TWENTY NINE PREDIABETES SUBJECTS AGED 30-75 YEARS. SETTING: YOGA WAS CONDUCTED AT 4 DIFFERENT COMMUNITY DIABETES CLINICS IN MANGALORE, INDIA. INTERVENTIONS: PARTICIPANTS WERE RANDOMIZED TO EITHER 3-MONTH YOGA OR WAIT-LIST CONTROL GROUPS. MAIN OUTCOME MEASURES: MALONDIALDEHYDE, GLUTATHIONE, VITAMIN C, VITAMIN E, SUPEROXIDE DISMUTASE, PLASMA GLUCOSE, GLYCATED HAEMOGLOBIN, BMI, WAIST CIRCUMFERENCE, WAIST-TO-HIP RATIO AND BLOOD PRESSURE. RESULTS: YOGA INTERVENTION RESULTED IN A SIGNIFICANT DECLINE IN MALONDIALDEHYDE (P<0.001), RELATIVE TO THE CONTROL GROUP. IN COMPARISON WITH THE CONTROL, THERE WAS A SIGNIFICANT IMPROVEMENT IN BMI, WAIST CIRCUMFERENCE, SYSTOLIC BLOOD PRESSURE AND FASTING GLUCOSE LEVELS AT FOLLOW-UP. NO SIGNIFICANT IMPROVEMENT IN GLYCATED HAEMOGLOBIN, WAIST-TO-HIP RATIO OR ANY OF THE ANTIOXIDANTS WAS OBSERVED. CONCLUSIONS: YOGA INTERVENTION MAY BE HELPFUL IN CONTROL OF OXIDATIVE STRESS IN PREDIABETES SUBJECTS. YOGA CAN ALSO BE BENEFICIAL IN REDUCTION IN BMI, WAIST CIRCUMFERENCE, SYSTOLIC BLOOD PRESSURE AND FASTING GLUCOSE. EFFECT OF YOGA ON ANTIOXIDANT PARAMETERS WAS NOT EVIDENT IN THIS STUDY. THE FINDINGS OF THIS STUDY NEED TO BE CONFIRMED IN LARGER TRIALS INVOLVING ACTIVE CONTROL GROUPS.	2013	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
12 2075  51 THE EFFECT OF BIKRAM YOGA ON ARTERIAL STIFFNESS IN YOUNG AND OLDER ADULTS. BACKGROUND AND OBJECTIVE: BIKRAM YOGA IS THE MOST POPULAR FORM OF HOT YOGA, DESPITE THE LIMITED INFORMATION AVAILABLE ON ITS CARDIOVASCULAR BENEFITS. THIS STUDY SOUGHT TO DETERMINE THE EFFECT OF BIKRAM YOGA ON ARTERIAL STIFFNESS AND INSULIN RESISTANCE IN YOUNG AND OLDER ADULTS. METHODS: TWENTY-FOUR YOUNG (MEAN AGE+/-STANDARD DEVIATION, 30+/-1 YEARS) AND 18 MIDDLE-AGED AND OLDER (MEAN AGE, 53+/-2 YEARS) ADULTS COMPLETED AN 8-WEEK BIKRAM YOGA INTERVENTION. BIKRAM YOGA CLASSES WERE PERFORMED FOR 90 MINUTES PER SESSION, THREE TIMES PER WEEK, IN A ROOM HEATED TO 40.5 DEGREES C WITH 40%--60% RELATIVE HUMIDITY. RESULTS: BODY MASS, BODY FAT PERCENTAGE, BLOOD PRESSURE, AND FASTING BLOOD GLUCOSE AND TRIGLYCERIDE CONCENTRATIONS DID NOT SIGNIFICANTLY CHANGE AS A RESULT OF THE INTERVENTION IN EITHER THE YOUNG OR THE OLDER GROUP. TRUNK FLEXIBILITY, AS MEASURED BY THE SIT-AND-REACH TEST, INCREASED IN BOTH GROUPS (P<0.01). TOTAL (P<0.05) AND LOW-DENSITY LIPOPROTEIN CHOLESTEROL (P<0.05) LEVELS, PLASMA INSULIN CONCENTRATIONS (P<0.01), AND SCORES ON THE HOMEOSTATIC MODEL OF THE ASSESSMENT OF INSULIN RESISTANCE (P<0.01) DECREASED IN OLDER ADULTS, WHEREAS TOTAL AND HIGH-DENSITY LIPOPROTEIN CHOLESTEROL CONCENTRATIONS WERE REDUCED IN YOUNG ADULTS (ALL P<0.05). CAROTID ARTERY COMPLIANCE (P<0.05) WAS INCREASED AND BETA-STIFFNESS INDEX DECREASED IN YOUNG (P<0.05) BUT NOT IN OLDER ADULTS. CAROTID PULSE PRESSURE DID NOT SIGNIFICANTLY CHANGE IN EITHER GROUP. CONCLUSION: A RELATIVELY SHORT-TERM BIKRAM YOGA INTERVENTION IMPROVED ARTERIAL STIFFNESS IN YOUNG BUT NOT OLDER ADULTS AND SIGNIFICANTLY REDUCED INSULIN RESISTANCE INDEX IN OLDER BUT NOT YOUNG ADULTS.	2013	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
13  300  30 AN ASSESSMENT OF A SEQUENCE OF YOGA EXERCISES TO PATIENTS WITH ARTERIAL HYPERTENSION. THIS QUASI-EXPERIMENTAL STUDY DESCRIBES THE EFFECTS OF A YOGA SEQUENCE FOLLOWING HEMODYNAMIC AND BIOCHEMICAL PARAMETERS IN PATIENTS WITH HYPERTENSION. THIRTY-THREE VOLUNTEERS PARTICIPATED IN THE STUDY (CONTROL = 16 AND YOGA = 17) FOR FOUR MONTHS. BLOOD PRESSURE MEASUREMENTS, CARDIAC AND RESPIRATORY RATE WERE COLLECTED MONTHLY, WHILE THE BIOCHEMICAL PROFILE WAS TAKEN AT THE BEGINNING AND END OF THE PROGRAM. TO ANALYZE THE DATA, STUDENT'S T TEST AND REPEATED MEASURES ANALYSES WERE PERFORMED. THE YOGA GROUP SHOWED A SIGNIFICANT REDUCTION OF SYSTOLIC BLOOD PRESSURE, HEART AND RESPIRATORY RATE (P < 0.05). AS FOR THE BIOCHEMICAL PROFILE, THE YOGA GROUP SHOWED CORRELATION COEFFICIENTS BETWEEN INITIAL VALUES AND FINAL RESPONSES GREATER THAN THE CONTROL OF FASTING GLUCOSE, TOTAL CHOLESTEROL, LDL-CHOLESTEROL AND TRIGLYCERIDES. THE ELABORATED SEQUENCE PRACTICE PROMOTED SIGNIFICANT CARDIOVASCULAR AND METABOLIC BENEFITS. THE YOGA EXERCISES PERFORMED IN THE PROPOSED SEQUENCE CONSTITUTE COMPLEMENTARY NON-PHARMACOLOGICAL CONTROL OF BLOOD PRESSURE IN PATIENTS WITH HYPERTENSION.	2013	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
14  705  53 EFFECT OF INTEGRATED APPROACH OF YOGA THERAPY ON AUTONOMIC FUNCTIONS IN PATIENTS WITH TYPE 2 DIABETES. BACKGROUND AND OBJECTIVES: INTEGRATED APPROACH OF YOGA THERAPY (IAYT) HAD SHOWN BENEFICIAL EFFECTS IN THE MANAGEMENT OF TYPE 2 DIABETES MELLITUS (DM). AUTONOMIC DYSFUNCTION IS ONE OF THE MAJOR COMPLICATIONS OF TYPE 2 DM. RESEARCH STUDIES HAVE DEMONSTRATED THAT YOGA CAN MODULATE AUTONOMIC FUNCTIONS. HENCE, THE CURRENT STUDY WAS DESIGNED TO ASSESS THE EFFECT OF IAYT ON AUTONOMIC FUNCTIONS IN TYPE 2 DIABETICS. MATERIALS AND METHODS: 15 PATIENTS OF TYPE 2 DM WITH AGES RANGING FROM 35 TO 60 YEARS WERE RECRUITED FOR THE STUDY. THEY WERE DIAGNOSED WITH TYPE 2 DIABETES FROM 1-YEAR TO 15 YEARS. ASSESSMENTS WERE MADE ON DAY 1 (BEFORE YOGA) AND DAY 7 (AFTER 1-WEEK OF YOGA PRACTICE). HEART RATE VARIABILITY (HRV), BLOOD PRESSURE (BP) RESPONSE TO THE ISOMETRIC HANDGRIP AND HEART RATE RESPONSE TO DEEP BREATHING WERE ASSESSED BEFORE AND AFTER 1-WEEK OF IAYT. RESULTS: THERE WAS A SIGNIFICANT REDUCTION IN FASTING PLASMA GLUCOSE FROM 154.67-130.27 MG/DL (WILCOXON SIGNED RANK TEST, P = 0.029) FOLLOWING 1-WEEK OF IAYT. BP RESPONSE TO ISOMETRIC HAND GRIP IMPROVED SIGNIFICANTLY (WILCOXON SIGNED RANK TEST, P = 0.01). THERE WAS NO STATISTICAL SIGNIFICANT CHANGE IN HRV COMPONENTS AND HEART RATE RESPONSE TO DEEP BREATHING TEST. HOWEVER, THERE WAS A TREND OF INCREASE IN THE LOW FREQUENCY POWER (41.07%), HIGH FREQUENCY POWER (6.29%), TOTAL POWER (5.38%), AND STANDARD DEVIATION OF ALL NN INTERVALS (SDNN) (6.29%). CONCLUSION: THESE FINDINGS SUGGEST THAT, IAYT IMPROVED AUTONOMIC FUNCTIONS IN TYPE 2 DIABETES PATIENTS.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
15  873  36 EFFECT OF YOGA THERAPY ON HEART RATE, BLOOD PRESSURE AND CARDIAC AUTONOMIC FUNCTION IN HEART FAILURE. BACKGROUND AND OBJECTIVE: IT IS WELL KNOWN THAT A HALL MARK OF HEART FAILURE IS ADVERSE CHANGES IN AUTONOMIC FUNCTION. ELEVATED BLOOD PRESSURE IS A POWERFUL PREDICTOR OF CONGESTIVE HEART FAILURE AND OTHER CARDIOVASCULAR DISEASE (CVD) OUTCOMES. IN THIS STUDY, WE PLANNED TO EXAMINE THE EFFECTS OF A 12 WEEK YOGA THERAPY ON BLOOD PRESSURE, HEART RATE, HEART RATE VARIABILITY, AND RATE PRESSURE PRODUCT (RPP). METHODS: OUT OF 130 HEART FAILURE PATIENTS RECRUITED FOR THE STUDY, 65 PATIENTS WERE RANDOMLY SELECTED TO RECEIVE 12 WEEK YOGA THERAPY ALONG WITH STANDARD MEDICAL THERAPY (YOGA GROUP). OTHER PATIENTS (N=65) RECEIVED ONLY STANDARD MEDICAL THERAPY (CONTROL GROUP). HEART RATE, BLOOD PRESSURE, CARDIAC AUTONOMIC FUNCTION (BY SHORT-TERM HEART-RATE VARIABILITY ANALYSIS) AND MYOCARDIAL OXYGEN CONSUMPTION (BY RPP) WERE ASSESSED BEFORE AND AFTER 12 WEEKS. IN THE YOGA GROUP, 44 PATIENTS AND IN THE CONTROL GROUP, 48 PATIENTS COMPLETED THE STUDY. RESULTS: THERE WAS A SIGNIFICANT DECREASE IN HEART RATE, BLOOD PRESSURE AND RPP IN YOGA GROUP COMPARED TO CONTROL GROUP. ALSO, LFNU AND LF-HF RATIO DECREASED SIGNIFICANTLY AND HFNU INCREASED SIGNIFICANTLY IN YOGA GROUP COMPARED TO CONTROL GROUP. CONCLUSION: TWELVE-WEEK YOGA THERAPY SIGNIFICANTLY IMPROVED THE PARASYMPATHETIC ACTIVITY AND DECREASED THE SYMPATHETIC ACTIVITY IN HEART FAILURE PATIENTS (NYHA I&II).	2014	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
16  938  43 EFFECTS OF 1-YEAR YOGA ON CARDIOVASCULAR RISK FACTORS IN MIDDLE-AGED AND OLDER ADULTS WITH METABOLIC SYNDROME: A RANDOMIZED TRIAL. BACKGROUND: METABOLIC SYNDROME (METS) IS A CLUSTERING OF CARDIOVASCULAR RISK FACTORS, WHICH IS ASSOCIATED WITH DIABETES MELLITUS AND CARDIOVASCULAR DISEASE. LIFESTYLE INTERVENTIONS APPLIED TO PEOPLE WITH METS HAS CONSIDERABLE BENEFICIAL EFFECTS ON DISEASE PREVENTIVE OUTCOMES. THIS STUDY AIMED TO EXAMINE THE EFFECTS OF 1-YEAR OF YOGA EXERCISE ON THE CARDIOVASCULAR RISK FACTORS INCLUDING CENTRAL OBESITY, HYPERTENSION, DYSLIPIDEMIA AND HYPERGLYCEMIA IN MIDDLE-AGED AND OLDER HONG KONG CHINESE ADULTS WITH METS. METHODS: ADULTS DIAGNOSED WITH METS USING NATIONAL CHOLESTEROL EDUCATION PROGRAM CRITERIA (N = 182; MEAN +/- SD AGE = 56 +/- 9.1) WERE RANDOMLY ASSIGNED TO A 1-YEAR YOGA INTERVENTION GROUP OR CONTROL GROUP. SYSTOLIC AND DIASTOLIC BLOOD PRESSURE, WAIST CIRCUMFERENCE, FASTING PLASMA GLUCOSE, TRIGLYCERIDES, AND HIGH-DENSITY LIPOPROTEIN CHOLESTEROL WERE EXAMINED AT BASELINE, MIDWAY, AND ON COMPLETION OF THE STUDY. PHYSICAL ACTIVITY LEVEL AND CALORIC INTAKE WERE ASSESSED AND INCLUDED IN THE COVARIATE ANALYSES. RESULTS: A REDUCTION OF THE NUMBER OF DIAGNOSTIC COMPONENTS FOR METS WAS FOUND TO BE ASSOCIATED WITH THE YOGA INTERVENTION. WAIST CIRCUMFERENCE WAS SIGNIFICANTLY IMPROVED AFTER THE 1-YEAR YOGA INTERVENTION. A TREND TOWARDS A DECREASE IN SYSTOLIC BLOOD PRESSURE WAS OBSERVED FOLLOWING YOGA INTERVENTION. CONCLUSION: THESE RESULTS SUGGEST THAT YOGA EXERCISE IMPROVES THE CARDIOVASCULAR RISK FACTORS INCLUDING CENTRAL OBESITY AND BLOOD PRESSURE IN MIDDLE-AGED AND OLDER ADULTS WITH METS. THESE FINDINGS SUPPORT THE COMPLEMENTARY BENEFICIAL ROLE OF YOGA IN MANAGING METS.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
17 2153  28 THE EFFECTS OF SUDARSHAN KRIYA YOGA ON SOME PHYSIOLOGICAL AND BIOCHEMICAL PARAMETERS IN MILD HYPERTENSIVE PATIENTS. AN OPEN LABEL INTERVENTION STUDY WAS UNDERTAKEN ON 26 MILD HYPERTENSIVES AND 26 APPARENTLY HEALTHY ADULTS (30-60 Y), FOR THE EFFECT OF SUDARSHAN KRIYA YOGA PRACTICE FOR TWO MONTHS AS COMPLEMENTARY THERAPY. IN THE HYPERTENSIVES, THERE WAS A SIGNIFICANT DECREASE IN DIASTOLIC BLOOD PRESSURE (P < 0.01), SERUM UREA (P < 0.01) AND PLASMA MDA (MALONDIALDEHYDE ADDUCTS) AS OXIDATIVE STRESS MARKER (P < 0.05). OTHER PARAMETERS; VIZ.; PLASMA LEVELS OF CHOLESTEROL, TRIGLYCERIDES, GLUCOSE, DID NOT CHANGE SIGNIFICANTLY (P > 0.1). THE PATTERN OF CHANGE IN MOST OF THE STUDY PARAMETERS WAS SUCH THAT VALUES ABOVE NORMAL RANGE WERE LOWERED BUT VALUES WITHIN NORMAL RANGE WERE UNALTERED. THE ACTION OF YOGA ON DIASTOLIC BLOOD PRESSURE, MALONDIALDEHYDE ADDUCTS AND KIDNEY FUNCTION IN HYPERTENSIVES WAS OF COUNTERACTIVE NATURE AND FELT TO BE DISTINCTLY DIFFERENT THAN THE EFFECT OF DRUGS.	2011	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
18 1491  54 INTERLEUKIN-6, VITAMIN D & DIABETES RISK-FACTORS MODIFIED BY A SHORT-TERM YOGA-BASED LIFESTYLE INTERVENTION IN OVERWEIGHT/OBESE INDIVIDUALS. BACKGROUND & OBJECTIVES: SEVERAL DIABETES PREVENTION PROGRAMMES HAVE DEMONSTRATED A REDUCTION IN INCIDENCE OF DIABETES IN INDIVIDUALS WITH PREDIABETES THROUGH WEIGHT LOSS. SHORT-TERM YOGA-BASED LIFESTYLE INTERVENTION PROGRAMMES HAVE ALSO BEEN SHOWN TO BE EFFICACIOUS IN WEIGHT LOSS. THIS STUDY WAS UNDERTAKEN TO INVESTIGATE IF INTERLEUKIN (IL)-6, VITAMIN D, NEOPTERIN, VASPIN, AND DIABETES RISK FACTORS CAN BE MODIFIED BY A SHORT-TERM YOGA-BASED LIFESTYLE INTERVENTION IN OVERWEIGHT/OBESE SUBJECTS. METHODS: IN THIS PILOT STUDY, 34 OVERWEIGHT/OBESE [BODY MASS INDEX (BMI) >/= 23 TO <35 KG/M [2] PER ASIAN CUT-OFF VALUES] INDIVIDUALS WERE ENROLLED, AND RECEIVED DIRECTLY SUPERVISED INTERVENTION FOR 10 DAYS. THEREAFTER, THEY WERE ADVISED TO FOLLOW THIS YOGA-BASED LIFESTYLE AT HOME FOR ONE MONTH, AND WERE REASSESSED FOR STUDY VARIABLES AT DAY 30. RESULTS: THERE WAS A REDUCTION FROM BASELINE TO DAY 10 IN WEIGHT ( P <0.001), BMI ( P <0.001), WAIST/HIP-RATIO ( P <0.05), BLOOD GLUCOSE ( P <0.01), AND A SIGNIFICANT IMPROVEMENT IN LIPID PROFILE. THERE WAS A DECREASE IN MEDIAN FASTING INSULIN ( P <0.05), HOMEOSTATIC MODEL ASSESSMENT-INSULIN RESISTANCE ( P <0.01), AND IL-6 ( PP <0.05). A NON-SIGNIFICANT INCREASE IN 25-OH-VITAMIN D, AND A DECREASE IN NEOPTERIN AND VASPIN WERE OBSERVED. TWENTY SUBJECTS RETURNED FOR FOLLOW UP ASSESSMENTS. AT DAY 30, WEIGHT LOSS WAS SUSTAINED WHILE SYSTOLIC BLOOD PRESSURE ALSO SHOWED REDUCTION ( P <0.05). CHANGES IN VITAMIN D LEVELS WERE SIGNIFICANTLY AND NEGATIVELY CORRELATED WITH CHANGES IN WEIGHT, BMI AND FASTING BLOOD GLUCOSE, AND POSITIVELY WITH CHANGE IN HIGH DENSITY LIPOPROTEIN. CHANGES IN BODY WEIGHT AND BMI SIGNIFICANTLY AND POSITIVELY CORRELATED WITH INSULIN. CHANGES IN IL-6 LEVELS POSITIVELY AND SIGNIFICANTLY CORRELATED WITH CHANGE IN NEOPTERIN LEVELS. INTERPRETATION & CONCLUSIONS: THE FINDINGS SHOWED THAT IL-6, VITAMIN D, AND DIABETES RISK FACTORS WERE FAVOURABLY MODIFIED BY A SHORT-TERM YOGA-BASED LIFESTYLE INTERVENTION IN OBESITY. THIS STUDY ALSO HIGHLIGHTED THE CHALLENGES IN COMPLIANCE ASSOCIATED WITH THE FOLLOW UP OF SUBJECTS FOLLOWING AN AGGRESSIVE SUPERVISED INTERVENTION OF 10 DAYS.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
19  739  36 EFFECT OF RAJA YOGA MEDITATION ON THE LIPID PROFILE OF POST-MENOPAUSAL WOMEN. BACKGROUND: CORONARY ARTERY DISEASE IS AN IMPORTANT CAUSE OF DEATH AND DISABILITY AMONG OLDER WOMEN. MODIFICATION IN LIPID PROFILE LOWERS THE RISK OF CORONARY ARTERY DISEASE. IT IS CLAIMED THAT YOGA AND TRANSCENDENTAL MEDITATION HAVE A CHOLESTEROL LOWERING EFFECT. THIS STUDY WAS DESIGNED TO ASSESS THE EFFECT OF RAJA YOGA MEDITATION OF BRAHMAKUMARIS WHICH IS VERY SIMPLE TO PRACTICE, ON SERUM LIPIDS IN NORMAL INDIAN WOMEN. METHODS AND RESULTS: 49 NORMAL FEMALE VOLUNTEERS WERE THE SUBJECTS. THEY WERE DIVIDED INTO PRE-MENOPAUSAL (N=23) AND POST-MENOPAUSAL (N=26) GROUPS. THEY WERE FURTHER DIVIDED INTO NON-MEDITATORS (WHO HAD NEVER DONE ANY KIND OF MEDITATION), SHORT-TERM MEDITATORS (MEDITATING FOR 6 MONTHS TO 5 YEARS) AND LONG-TERM MEDITATORS (MEDITATING FOR MORE THAN 5 YEARS). LIPID PROFILE WAS ASSESSED USING THEIR RESPECTIVE REAGENT SETS. SERUM CHOLESTEROL, TRIGLYCERIDE AND LOW-DENSITY LIPOPROTEIN-CHOLESTEROL IN NONMEDITATORS WERE SIGNIFICANTLY MORE IN POST-MENOPAUSAL WOMEN AS COMPARED TO PRE-MENOPAUSAL WOMEN. SERUM CHOLESTEROL AND LOW DENSITY LIPOPROTEIN-CHOLESTEROL WERE SIGNIFICANTLY LOWERED IN BOTH SHORT AND LONG TERM MEDITATORS AS COMPARED TO NON-MEDITATORS IN POST-MENOPAUSAL WOMEN. NO SIGNIFICANT DIFFERENCE WAS OBSERVED IN LIPID PROFILE IN PRE-MENOPAUSAL WOMEN. CONCLUSION: RAJA YOGA MEDITATION LOWERED SERUM CHOLESTEROL AND LOW-DENSITY LIPOPROTEIN-CHOLESTEROL IN POST-MENOPAUSAL WOMEN THUS REDUCING THE RISK OF CORONARY ARTERY DISEASE IN THEM.	2008	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
20  959  42 EFFECTS OF A YOGA INTERVENTION ON LIPID PROFILES OF DIABETES PATIENTS WITH DYSLIPIDEMIA. OBJECTIVE: THE PRESENT STUDY WAS CONDUCTED TO ASSESS THE EFFECTIVENESS OF YOGA IN THE MANAGEMENT OF DYSLIPIDEMIA IN PATIENTS OF TYPE 2 DIABETES MELLITUS. METHODS: THIS RANDOMIZED PARALLEL STUDY WAS CARRIED OUT IN MEDICAL COLLEGE TRIVANDRUM, KERALA, INDIA. HUNDRED TYPE 2 DIABETICS WITH DYSLIPIDEMIA WERE RANDOMIZED INTO CONTROL AND YOGA GROUPS. THE CONTROL GROUP WAS PRESCRIBED ORAL HYPOGLYCEMIC DRUGS. THE YOGA GROUP PRACTICED YOGA DAILY FOR 1 H DURATION ALONG WITH ORAL HYPOGLYCEMIC DRUGS FOR 3 MONTHS. THE LIPID PROFILES OF BOTH THE GROUPS WERE COMPARED AT THE START AND AT THE END OF 3 MONTHS. RESULTS: AFTER INTERVENTION WITH YOGA FOR A PERIOD OF 3 MONTHS THE STUDY GROUP SHOWED A DECREASE IN TOTAL CHOLESTEROL, TRIGLYCERIDES AND LDL, WITH AN IMPROVEMENT IN HDL. CONCLUSION: YOGA, BEING A LIFESTYLE INCORPORATING EXERCISE AND STRESS MANAGEMENT TRAINING, TARGETS THE ELEVATED LIPID LEVELS IN PATIENTS WITH DIABETES THROUGH INTEGRATED APPROACHES.	2013