1  816 139 EFFECT OF YOGA ON CLINICAL OUTCOMES AND QUALITY OF LIFE IN PATIENTS WITH VASOVAGAL SYNCOPE (LIVE-YOGA). OBJECTIVES: THIS STUDY AIMS TO DETERMINE THE IMPACT OF YOGA AS AN ADJUNCT TO STANDARD THERAPY VERSUS STANDARD THERAPY ALONE ON THE SYMPTOMATIC BURDEN IN PATIENTS WITH RECURRENT VASOVAGAL SYNCOPE (VVS). BACKGROUND: THERE IS A SIGNIFICANT REDUCTION IN THE QUALITY OF LIFE (QOL) OF PATIENTS WITH RECURRENT VVS. EXISTING MANAGEMENT THERAPIES HAVE BEEN LARGELY INEFFECTIVE. RECENT TRIALS HAVE DEMONSTRATED THE EFFICACY OF YOGA IN DISEASES WITH AUTONOMIC IMBALANCE, SUGGESTING ITS POSSIBLE UTILITY IN VVS. METHODS: PATIENTS WITH RECURRENT VVS WERE RANDOMIZED TO RECEIVE EITHER A SPECIALIZED YOGA TRAINING PROGRAM IN ADDITION TO CURRENT GUIDELINE-BASED THERAPY (INTERVENTION ARM, GROUP 1) OR CURRENT GUIDELINE-BASED THERAPY ALONE (CONTROL ARM, GROUP 2). THE PRIMARY OUTCOME WAS A COMPOSITE OF THE NUMBER OF EPISODES OF SYNCOPE AND PRESYNCOPE AT 12 MONTHS. SECONDARY OUTCOMES INCLUDED QOL ASSESSMENT BY WORLD HEALTH ORGANIZATION QUALITY OF LIFE BRIEF FIELD QUESTIONNAIRE (WHOQOL-BREF) SCORES AND SYNCOPE FUNCTIONAL STATUS QUESTIONNAIRE SCORES AT 12 MONTHS, HEAD UP TILT TEST, AND HEART RATE VARIABILITY AT 6 WEEKS. RESULTS: A TOTAL OF 55 PATIENTS UNDERWENT RANDOMIZATION. THE MEAN NUMBER OF SYNCOPAL OR PRESYNCOPAL EVENTS AT 12 MONTHS WAS 0.7 +/- 0.7 IN THE INTERVENTION ARM COMPARED TO 2.52 +/- 1.93 IN THE CONTROL ARM (P < 0.01). IN THE INTERVENTION ARM, 13 (43.3%) PATIENTS REMAINED FREE OF EVENTS VERSUS 4 (16.0%) PATIENTS IN THE CONTROL ARM (P = 0.02). QOL AT 12 MONTHS SHOWED SIGNIFICANT IMPROVEMENT OF ALL SYNCOPE FUNCTIONAL STATUS QUESTIONNAIRE SCORES AND 2 DOMAINS OF WHOQOL-BREF SCORES (P < 0.05). CONCLUSIONS: YOGA AS ADJUNCTIVE THERAPY IS SUPERIOR TO STANDARD THERAPY ALONE IN REDUCING THE SYMPTOMATIC BURDEN AND IMPROVING QOL IN PATIENTS WITH RECURRENT VVS.	2022	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
2  190  57 A RANDOMIZED STUDY OF YOGA THERAPY FOR THE PREVENTION OF RECURRENT REFLEX VASOVAGAL SYNCOPE. AIMS: VASOVAGAL SYNCOPE (VVS) IS A COMMON CARDIOVASCULAR DYSAUTONOMIC DISORDER THAT SIGNIFICANTLY IMPACTS HEALTH AND QUALITY OF LIFE (QOL). YOGA HAS BEEN SHOWN TO HAVE A POSITIVE INFLUENCE ON CARDIOVASCULAR AUTONOMICS. THIS STUDY ASSESSED THE EFFECTIVENESS OF YOGA THERAPY ON THE RECURRENCE OF VVS AND QOL. METHODS AND RESULTS: WE RANDOMIZED SUBJECTS WITH RECURRENT REFLEX VVS (>3 EPISODES IN THE PAST 1 YEAR) AND POSITIVE HEAD-UP TILT TEST TO GUIDELINE-DIRECTED THERAPY (GROUP 1) OR YOGA THERAPY (GROUP 2). PATIENTS IN GROUP 1 WERE ADVISED GUIDELINE-DIRECTED TREATMENT AND GROUP 2 WAS TAUGHT YOGA BY A CERTIFIED INSTRUCTOR. THE PRIMARY ENDPOINT WAS VVS RECURRENCES AND QOL. BETWEEN JUNE 2015 AND FEBRUARY 2017, 97 HIGHLY SYMPTOMATIC VVS PATIENTS WERE RANDOMIZED (GROUP 1: 47 AND GROUP 2: 50). THE MEAN AGE WAS 33.1 +/- 16.6 YEARS, MALE:FEMALE OF 40:57, SYMPTOM DURATION OF 17.1 +/- 20.7 MONTHS, WITH A MEAN OF 6.4 +/- 6.1 SYNCOPE EPISODES. OVER A FOLLOW-UP OF 14.3 +/- 2.1 MONTHS GROUP 2 HAD SIGNIFICANTLY LOWER SYNCOPE BURDEN COMPARED WITH GROUP 1 AT 3 (0.8 +/- 0.9 VS. 1.8 +/- 1.4, P < 0.001), 6 (1.0 +/- 1.2 VS. 3.4 +/- 3.0, P < 0.001), AND AT 12 MONTHS (1.1 +/- 0.8 VS. 3.8 +/- 3.2, P < 0.001). THE SYNCOPE FUNCTIONAL SCORE QUESTIONNAIRE WAS SIGNIFICANTLY LOWER IN GROUP 2 COMPARED WITH GROUP 1 AT 3 (31.4 +/- 7.2 VS. 64.1 +/- 11.5, P < 0.001), 6 (26.4 +/- 6.3 VS. 61.4 +/- 10.7, P < 0.001), AND 12 MONTHS (22.2 +/- 4.7 VS. 68.3 +/- 11.4, P < 0.001). CONCLUSION: FOR PATIENTS WITH RECURRENT VVS, GUIDED YOGA THERAPY IS SUPERIOR TO CONVENTIONAL THERAPY IN REDUCING SYMPTOM BURDEN AND IMPROVING QOL.	2021	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
3 2471  58 YOGA AS A TREATMENT FOR VASOVAGAL SYNCOPE: A SYSTEMATIC REVIEW AND META-ANALYSIS. BACKGROUND: YOGA THERAPY IS BEING USED FOR VASOVAGAL SYNCOPE (VVS). HOWEVER, THERE IS NO SUFFICIENT EVIDENCE. WE AIMED TO EVALUATE THE EFFECT OF YOGA AS AN ADJUNCT TO THE STANDARD THERAPY ON PATIENTS WITH RECURRENT VVS. METHODS: ELECTRONIC DATABASES WERE SYSTEMATICALLY SEARCHED TO COLLECT STUDIES ASSESSING THE CLINICAL EFFECTS OF YOGA ALONG WITH GUIDELINE-DIRECTED TREATMENT IN PATIENTS WITH RECURRENT VVS. THE OUTCOMES WERE THE NUMBER OF VVS ATTACKS AND QUALITY OF LIFE (QOL) ASSESSMENT BY SYNCOPE FUNCTIONAL STATUS QUESTIONNAIRE (SFSQ) SCORES AT 12 MONTHS. WE USED THE MANTEL- HAENSZEL RANDOM-EFFECTS MODEL TO CALCULATE THE MEAN DIFFERENCE (MD) AND 95% CONFIDENCE INTERVAL (CI). WE USED THE COCHRANE COLLABORATION RISK OF BIAS TOOL AND NEWCASTLE-OTTAWA SCALE FOR RISK OF BIAS ASSESSMENT. RESULTS: FOUR STUDIES WERE INCLUDED, TWO RCTS AND TWO OBSERVATIONAL STUDIES. THE TOTAL OF PARTICIPANTS WAS 309, WITH A MEAN AGE OF 36.4 +/- 13.5 YEARS. THE MALE PARTICIPANTS REPRESENTED 141 (45.6%) BEING MALES. THE BASELINE SYNCOPE BURDEN WAS 3.5 +/- 2.38 EPISODES OVER 15.6 +/- 12.8 MONTHS. YOGA THERAPY SIGNIFICANTLY REDUCED THE NUMBER OF EPISODES OF SYNCOPE AND PRESYNCOPE COMPARED TO THE CONTROL GROUP (MD -1.86; 95% CI -3.30, -0.43; P = 0.01). NEVERTHELESS, YOGA THERAPY DID NOT SHOW SIGNIFICANT IMPROVEMENT IN THE QOL ASSESSED BY SFSQ SCORES (MD -30.69; 95% CI -62.22,0.83; P = 0.06). CONCLUSION: YOGA THERAPY IS A USEFUL LIFESTYLE INTERVENTION THAT CAN REDUCE THE FREQUENCY OF SYNCOPE AND PRESYNCOPE AMONG PATIENTS WITH RECURRENT VVS. HOWEVER, HIGHER-QUALITY RCTS ARE NEEDED TO CONFIRM OUR RESULTS.	2022	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
4 2486  26 YOGA AS AN INTEGRATIVE APPROACH FOR PREVENTION AND TREATMENT OF ORAL CANCER. DESPITE TREMENDOUS ADVANCEMENTS IN MEDICINE, THE NUMBER OF ORAL CANCER CASES CONTINUES TO INCREASE, AND THE NEED FOR INTEGRATING ALTERNATE MEDICINE OR ADOPTING AN INTEGRATIVE APPROACH HAS BECOME A COMPELLING COST-EFFECTIVE REQUIREMENT FOR THE MANAGEMENT AND TREATMENT OF DISEASES. CONVENTIONAL TREATMENT OF ORAL CANCER INVOLVES SURGERY FOLLOWED BY RADIOTHERAPY WITH OR WITHOUT CHEMOTHERAPY WHICH CAUSES SEVERAL COMPLICATIONS INCLUDING POOR QUALITY OF LIFE AND HIGH CHANCES OF RECURRENCE OF CANCER. ORAL CANCER IS OFTEN LINKED WITH OBESITY WHICH IS MAJOR RISK FACTORS IN OTHER CANCERS. APART FROM OBESITY, ORAL CANCER IS THOUGHT TO HAVE AN INVERSE RELATION WITH NEURODEGENERATIVE DISORDERS PRESUMABLY BECAUSE CELL DEATH DECREASES IN THE FORMER CASE AND INCREASES IN THE LATTER. ANCIENT MIND-BODY TECHNIQUES SUCH AS YOGA HAVE NOT BEEN ADEQUATELY TESTED AS A TOOL TO SYNERGIZE THE CELLULAR EQUILIBRIUM PERTAINING TO THE TREATMENT OF ORAL CANCER. NERVE GROWTH FACTOR (NGF), TUMOR NECROSIS FACTOR-ALPHA (TNF-ALPHA), AND INTERLEUKIN-6 (IL-6) ARE AMONG THE EARLY EXPERIMENTAL CELLULAR BIOMARKERS THAT MAY BE USED TO PROBE THE MODULATION OF ORAL CANCER, OBESITY, AND NEURODEGENERATIVE DISORDERS. YOGA HAS BEEN REPORTED TO INFLUENCE THESE MOLECULES IN HEALTHY INDIVIDUALS BUT WHETHER THEIR EXPRESSION CAN BE ALTERED IN PATIENTS OF ORAL CANCER BY YOGA INTERVENTION IS THE SUBJECT OF THIS RESEARCH BEING DISCUSSED IN THIS REVIEW ARTICLE. THEREFORE, THE PRESENT ARTICLE NOT ONLY REVIEWS THE CURRENT STATUS OF RESEARCH STUDIES IN ORAL CANCER, OBESITY, AND NEURODEGENERATIVE DISORDERS BUT ALSO HOW THESE ARE LINKED TO EACH OTHER AND WHY THE INVESTIGATIONS OF THE PUTATIVE NGF PATHWAY, INVOLVING TNF-ALPHA AND IL-6, COULD PROVIDE USEFUL CLUES TO UNDERSTAND THE MOLECULAR EFFECTS BROUGHT ABOUT BY YOGA INTERVENTION IN SUCH PATIENTS.	2018	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
5 2035  24 TELE-YOGA FOR CHRONIC PAIN: CURRENT STATUS AND FUTURE DIRECTIONS. PAIN IS A PERVASIVE, DEBILITATING DISORDER THAT IS RESISTANT TO LONG-TERM PHARMACOLOGICAL INTERVENTIONS. ALTHOUGH PSYCHOLOGICAL THERAPIES SUCH AS COGNITIVE BEHAVIOR THERAPY DEMONSTRATE MODERATE EFFICACY, MANY INDIVIDUALS CONTINUE TO HAVE ONGOING DIFFICULTIES FOLLOWING TREATMENT. THERE IS A CURRENT TREND TO ESTABLISH COMPLEMENTARY AND INTEGRATIVE HEALTH INTERVENTIONS FOR CHRONIC PAIN, FOR WHICH YOGA HAS BEEN FOUND TO HAVE EXCITING POTENTIAL. NEVERTHELESS, AN IMPORTANT CONSIDERATION WITHIN THE FIELD IS ACCESSIBILITY TO ADEQUATE CARE. TELEHEALTH CAN BE USED TO PROVIDE REAL-TIME INTERACTIVE VIDEO CONFERENCING LEADING TO INCREASED ACCESS TO HEALTH CARE FOR INDIVIDUALS LOCATED REMOTELY OR WHO OTHERWISE HAVE DIFFICULTY ACCESSING SERVICES, PERHAPS THROUGH ISSUES OF MOBILITY OR PROXIMITY OF ADEQUATE SERVICES. THIS ARTICLE ASSESSES THE CURRENT STATUS AND FEASIBILITY OF IMPLEMENTING TELE-YOGA FOR CHRONIC PAIN. METHODOLOGICAL LIMITATIONS AND RECOMMENDATIONS FOR FUTURE RESEARCH ARE DISCUSSED.	2018	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
6  906  37 EFFECTIVENESS OF APP-BASED YOGA OF IMMORTALS (YOI) INTERVENTION FOR INSOMNIA IN ASIAN POPULATION DURING PANDEMIC RESTRICTIONS. THE CORONAVIRUS DISEASE 2019 (COVID-19) PANDEMIC CREATED SIGNIFICANT PSYCHOLOGICAL CHALLENGES WORLDWIDE, INCLUDING STRESS, EMOTIONAL DISTRESS, AND INSOMNIA. IN ADDITION, SOCIAL DISTANCING, TRAVEL RESTRICTIONS, AND SPREAD OF DISEASE HAVE RESULTED IN UNIQUE CHALLENGES, CREATING BARRIERS TO HEALTHCARE ACCESS. COMPARED TO THE RATE PRIOR TO THE COVID-19 PANDEMIC, A SIGNIFICANT INCREASE IN CLINICAL INSOMNIA RATES HAVE BEEN REPORTED. WITH WELL-KNOWN LIMITATIONS OF CURRENTLY ESTABLISHED TREATMENTS (E.G., COGNITIVE BEHAVIORAL THERAPY-INSOMNIA (CBT-I), PHARMACOTHERAPY), THERE IS A NEED TO EXPLORE OTHER EFFECTIVE AND SAFE TREATMENT MODALITIES TO TREAT INSOMNIA, ESPECIALLY THOSE THAT CAN BE USED REMOTELY. THE PURPOSE OF THIS STUDY IS TO ASSESS THE EFFECTIVENESS OF APP-BASED INTERVENTION TO TREAT INSOMNIA IN THE CURRENT ERA OF THE COVID-19 PANDEMIC (USING THE YOGA OF IMMORTALS (YOI) APP). THIS PROSPECTIVE COHORT STUDY WAS APPROVED BY THE INSTITUTIONAL REVIEW BOARD. ALL PARTICIPANTS IN THIS STUDY WERE ASKED TO COMPLETE AN ONLINE SURVEY INCLUDING DEMOGRAPHIC DATA AND VALIDATED INSOMNIA SEVERITY INDEX (ISI) AT BASELINE (15 MAY 2020), 4 WEEKS, AND 8 WEEKS AFTER STARTING THE YOI INTERVENTION. SURVEY DATA WAS EXPORTED USING MICROSOFT EXCEL. STATISTICAL ANALYSIS WAS DONE USING THE GRAPHPAD PRISM 8. YOI INTERVENTION SIGNIFICANTLY IMPROVED THE MEAN ISI SCORES IN ALL CATEGORIES OF INSOMNIA (SEVERE, MODERATE, AND SUBTHRESHOLD) AT EACH FOLLOW-UP (P </= 0.0001). THE IMPROVEMENT WAS SIGNIFICANT AMONG ALL AGE GROUPS AND IN BOTH GENDERS. IN OUR STUDY, YOI WAS A NOVEL AND EFFECTIVE INTERVENTION FOR IMPROVING INSOMNIA SYMPTOMS AND MAY BE A NEW ADDITION TO THE ARMAMENTARIUM OF INSOMNIA MANAGEMENT. BEING APP-BASED, THIS HAS POTENTIAL WIDER APPLICABILITY, ESPECIALLY DURING THE CURRENT COVID-19 PANDEMIC.	2021	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
7 2224  31 THE IMPACT OF THE "YOGIC LIFESTYLE" ON CANCER PROGNOSIS AND SURVIVAL: CAN WE TARGET CANCER STEM CELLS WITH YOGA? CANCER HAS RECENTLY BEEN KNOWN TO ORIGINATE FROM STEM CELL-LIKE CELLS, CALLED CANCER STEM CELLS (CSCS). THEIR UNIQUE PROPERTIES OF SELF-DUPLICATION, MULTIPLICATION, AS WELL AS MIGRATION GIVE THE CSC RESISTANCE OVER CONVENTIONAL CANCER THERAPIES. NEWER THERAPIES ARE IN DEVELOPMENTAL STAGE TO TARGET THESE STEM CELL-LIKE POPULATIONS AND BECOME THE VANGUARD OF FUTURE TREATMENTS. SEVERAL COMPLEMENTARY AND ALTERNATIVE TREATMENTS HAVE BEEN USED IN CANCER MANAGEMENT AS AN ADJUNCT TO CONVENTIONAL THERAPY TO IMPROVE THE OVERALL QUALITY OF LIFE AND REDUCE RECURRENCE. YOGA STANDS AS THE THIRD MOST POPULAR OF ALL COMPLEMENTARY AND ALTERNATIVE MEDICINE TREATMENTS CURRENTLY USED IN CANCER PATIENTS TODAY. PRELIMINARY RESULTS SHOW THAT YOGA MODULATES NEURAL, HORMONAL, AND IMMUNE FUNCTIONS AT A CELLULAR LEVEL. THE SCOPE OF THIS COMMENTARY IS TO DISCUSS THE CURRENT EVIDENCE-BASED MEDICINE ON YOGA AND ITS EFFECT ON CSCS.	2017	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
8 2275  35 THE ROLE OF YOGA IN WORKING FROM HOME DURING THE COVID-19 GLOBAL LOCKDOWN. BACKGROUND: THE COVID-19 PANDEMIC HAS BECOME A MAJOR CAUSE OF STRESS AND ANXIETY WORLDWIDE. DUE TO THE GLOBAL LOCKDOWN, WORK, EMPLOYMENT, BUSINESSES AND THE ECONOMIC CLIMATE HAVE BEEN SEVERELY AFFECTED. IT HAS GENERATED STRESS AMONG PEOPLE FROM ALL SECTIONS OF SOCIETY, ESPECIALLY TO WORKERS WHO HAVE BEEN ASSIGNED TO CATER TO HEALTHCARE SERVICE OR THOSE CONSTRAINED TO SECURE DAILY ESSENTIAL ITEMS. IT IS WIDELY PERCEIVED THAT ELDERLY OR THOSE AFFECTED BY DIABETES, HYPERTENSION AND OTHER CARDIOVASCULAR DISEASES ARE PRONE TO COVID-19. AS PER AN ONGOING SURVEY, THE INITIAL DATA SHOWS THAT THE ABOVE-MENTIONED ANXIETY AND STRESS CAUSE INSOMNIA, AND HAS THE CONSIDERABLE POTENTIAL TO WEAKEN THE IMMUNE SYSTEM, THE SOLE PROTECTION AGAINST THE VIRUS. OBJECTIVE: THIS STUDY FOCUSES ON THE NEED OF YOGA PRACTICE AT WORK PLACES AND AT HOME DURING THE GLOBAL LOCKDOWN DUE TO THE COVID-19 PANDEMIC. METHODS: LITERATURE WAS SEARCHED USING PUBMED AND GOOGLE SCHOLAR FOR COVID-19-RELATED STRESS AND ANXIETY AT WORK AND SOCIETY DUE TO THE WORLDWIDE LOCKDOWN. THE PREDISPOSING COMORBIDITIES, VIRAL MECHANISM OF ACTION AND TREATMENT REGIMEN WERE ALSO SEARCHED. YOGA-BASED INTERVENTION STUDIES AND ONLINE PROGRAMS WERE ALSO SEARCHED. RESULTS: AS THE LOCKDOWN CANNOT LAST FOREVER AND WORKPLACES WILL HAVE TO BE FUNCTIONAL SOON, THERE IS AN INCREASED POSSIBILITY OF RECURRENT INFECTION. THEREFORE, YOGA CAN PROVIDE THE NECESSARY TOOL FOR RISK REDUCTION, AMELIORATION OF STRESS AND ANXIETY AND STRENGTHENING OF THE IMMUNE FUNCTION. THE ONLINE PLATFORMS PROVIDE A GOOD MEDIA FOR YOGA TRAINING AT WORK PLACES AND HOMES. CONCLUSION: DUE TO SOCIAL DISTANCING NORMS, THE AVAILABILITY OF YOGA TRAINERS HAS BECOME RESTRICTED. YOGA PRACTICE IS ACTIVELY SOUGHT TO ACHIEVE REDUCED ANXIETY AND STRESS SO THAT IMPROVED SLEEP MAY POSITIVELY IMPACT IMMUNITY. AS A CONSEQUENCE, THERE IS A SPURT IN SOCIAL MEDIA, CATERING TO DAILY ONLINE YOGA SESSIONS WHICH APPARENTLY PROVE USEFUL IN PROVIDING ACCESSIBLE MEANS TO ACHIEVE MENTAL AS WELL AS PHYSICAL WELL-BEING.	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                       
9   70  38 A FEASIBILITY STUDY EXAMINING THE IMPACT OF YOGA ON PSYCHOSOCIAL HEALTH AND SYMPTOMS IN PEDIATRIC OUTPATIENTS RECEIVING CHEMOTHERAPY. PURPOSE: PEDIATRIC CANCER PATIENTS EXPERIENCE SYMPTOMS THAT NEGATIVELY IMPACT QUALITY OF LIFE; YOGA MAY BE AN EFFECTIVE INTERVENTION. THE PRIMARY OBJECTIVE WAS TO DETERMINE THE FEASIBILITY OF A 10-WEEK, WEEKLY INDIVIDUALIZED YOGA INTERVENTION FOR CHILDREN AND ADOLESCENTS RECEIVING OUTPATIENT CANCER THERAPY PRIMARILY DELIVERED REMOTELY USING SKYPE. SECONDARY OBJECTIVES WERE TO DESCRIBE DEPRESSION, ANXIETY, ANGER, FATIGUE, QUALITY OF LIFE, AND SYMPTOMS AT 5 AND 10 WEEKS AFTER ENROLLMENT. METHODS: WE INCLUDED ENGLISH-SPEAKING PATIENTS AGED 10 TO 18 YEARS RECEIVING OUTPATIENT CHEMOTHERAPY FOR CANCER. WEEKLY INDIVIDUALIZED YOGA SESSIONS WERE OFFERED FOR 10 WEEKS. WEEKS 1, 5, AND 10 WERE IN-HOSPITAL WHILE THE REMAINING SESSIONS WERE DELIVERED REMOTELY USING SKYPE. TWICE WEEKLY, HOMEWORK WAS ASSIGNED BETWEEN EACH SESSION. THE PRIMARY OUTCOME WAS FEASIBILITY, DEFINED AS 80% OF PARTICIPANTS COMPLETING AT LEAST 60% OF PLANNED IN-HOSPITAL OR REMOTE YOGA SESSIONS. RESULTS: BETWEEN MARCH AND NOVEMBER 2017, 10 PATIENTS WERE ENROLLED. TWO PATIENTS DISCONTINUED THE STUDY AFTER ONE AND TWO SESSIONS. ONLY SIX PARTICIPANTS ACHIEVED AT LEAST 60% OF PLANNED YOGA SESSIONS AND THUS, THE STUDY DID NOT MEET THE A PRIORI DEFINED FEASIBILITY THRESHOLD. AMONG ALL PARTICIPANTS, ONLY ONE HOMEWORK SESSION WAS PERFORMED. CONCLUSIONS: A 10-WEEK INDIVIDUALIZED IN-PERSON AND REMOTELY CONDUCTED YOGA INTERVENTION WAS NOT FEASIBLE IN CHILDREN RECEIVING CANCER TREATMENTS BECAUSE OF FAILURE TO ACHIEVE THE DESIRED FREQUENCY OF YOGA SESSIONS IN A SUFFICIENT NUMBER OF PARTICIPANTS. FUTURE RESEARCH SHOULD IDENTIFY APPROACHES TO IMPROVE COMPLIANCE WITH REMOTE YOGA SESSIONS AND HOME PRACTICE. TRIAL REGISTRATION: NCT03318068.	2019	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
10  132  42 A PRAGMATIC MULTICENTERED RANDOMIZED CONTROLLED TRIAL OF YOGA FOR CHRONIC LOW BACK PAIN: ECONOMIC EVALUATION. STUDY DESIGN: MULTICENTERED RANDOMIZED CONTROLLED TRIAL WITH QUALITY OF LIFE AND RESOURCE USE DATA COLLECTED. OBJECTIVE: THE OBJECTIVE OF THIS STUDY WAS TO EVALUATE THE COST-EFFECTIVENESS OF YOGA INTERVENTION PLUS USUAL CARE COMPARED WITH USUAL CARE ALONE FOR CHRONIC OR RECURRENT LOW BACK PAIN. SUMMARY OF BACKGROUND DATA: YOGA HAS BEEN SHOWN AS AN EFFECTIVE INTERVENTION FOR TREATING CHRONIC OR RECURRENT LOW BACK PAIN. HOWEVER, THERE IS LITTLE EVIDENCE ON ITS COST-EFFECTIVENESS. THE DATA ARE EXTRACTED FROM A PRAGMATIC, MULTICENTERED, RANDOMIZED CONTROLLED TRIAL THAT HAS BEEN CONDUCTED TO EVALUATE THE EFFECTIVENESS AND COST-EFFECTIVENESS OF A 12-WEEK PROGRESSIVE PROGRAM OF YOGA PLUS USUAL CARE IN PATIENTS WITH CHRONIC OR RECURRENT LOW BACK PAIN. METHODS: WITH THIS TRIAL DATA, A COST-EFFECTIVENESS ANALYSIS DURING THE TIME PERIOD OF 12 MONTHS FROM BOTH PERSPECTIVES OF THE UK NATIONAL HEALTH SERVICE AND THE SOCIETAL IS PRESENTED. MAIN OUTCOME MEASURE IS AN INCREMENTAL COST PER QUALITY-ADJUSTED LIFE-YEAR (QALY). RESULTS: FROM THE PERSPECTIVE OF THE U.K. NATIONAL HEALTH SERVICE, YOGA INTERVENTION YIELDS AN INCREMENTAL COST-EFFECTIVENESS RATIO OF POUND13,606 PER QALY. GIVEN A WILLINGNESS TO PAY FOR AN ADDITIONAL QALY OF POUND20,000, THE PROBABILITY OF YOGA INTERVENTION BEING COST-EFFECTIVE IS 72%. FROM THE PERSPECTIVE OF THE SOCIETY, YOGA INTERVENTION IS A DOMINANT TREATMENT COMPARED WITH USUAL CARE ALONE. THIS RESULT IS SURROUNDED BY FEWER UNCERTAINTIES-THE PROBABILITY OF YOGA BEING COST-EFFECTIVE REACHES 95% AT A WILLINGNESS TO PAY FOR AN ADDITIONAL QALY OF POUND20,000. SENSITIVE ANALYSES SUGGEST THE SAME RESULTS THAT YOGA INTERVENTION IS LIKELY TO BE COST-EFFECTIVE IN BOTH PERSPECTIVES. CONCLUSION: ON THE BASIS OF THIS TRIAL, 12 WEEKLY GROUP CLASSES OF SPECIALIZED YOGA ARE LIKELY TO BE A COST-EFFECTIVE INTERVENTION FOR TREATING PATIENTS WITH CHRONIC OR RECURRENT LOW BACK PAIN.	2012	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
11 1770  37 POTENTIAL LONG-TERM EFFECTS OF A MIND-BODY INTERVENTION FOR WOMEN WITH MAJOR DEPRESSIVE DISORDER: SUSTAINED MENTAL HEALTH IMPROVEMENTS WITH A PILOT YOGA INTERVENTION. DESPITE PHARMACOLOGIC AND PSYCHOTHERAPEUTIC ADVANCES OVER THE PAST DECADES, MANY INDIVIDUALS WITH MAJOR DEPRESSIVE DISORDER (MDD) EXPERIENCE RECURRENT DEPRESSIVE EPISODES AND PERSISTENT DEPRESSIVE SYMPTOMS DESPITE TREATMENT WITH THE USUAL CARE. YOGA IS A MIND-BODY THERAPEUTIC MODALITY THAT HAS RECEIVED ATTENTION IN BOTH THE LAY AND RESEARCH LITERATURE AS A POSSIBLE ADJUNCTIVE THERAPY FOR DEPRESSION. ALTHOUGH PROMISING, RECENT FINDINGS ABOUT THE POSITIVE MENTAL HEALTH EFFECTS OF YOGA ARE LIMITED BECAUSE FEW STUDIES HAVE USED STANDARDIZED OUTCOME MEASURES AND NONE OF THEM HAVE INVOLVED LONG-TERM FOLLOW-UP BEYOND A FEW MONTHS AFTER THE INTERVENTION PERIOD. THE GOAL OF OUR RESEARCH STUDY WAS TO EVALUATE THE FEASIBILITY, ACCEPTABILITY, AND EFFECTS OF A YOGA INTERVENTION FOR WOMEN WITH MDD USING STANDARDIZED OUTCOME MEASURES AND A LONG FOLLOW-UP PERIOD (1YEAR AFTER THE INTERVENTION). THE KEY FINDING IS THAT PREVIOUS YOGA PRACTICE HAS LONG-TERM POSITIVE EFFECTS, AS REVEALED IN BOTH QUALITATIVE REPORTS OF PARTICIPANTS' EXPERIENCES AND IN THE QUANTITATIVE DATA ABOUT DEPRESSION AND RUMINATION SCORES OVER TIME. ALTHOUGH GENERALIZABILITY OF THE STUDY FINDINGS IS LIMITED BECAUSE OF A VERY SMALL SAMPLE SIZE AT THE 1-YEAR FOLLOW-UP ASSESSMENT, THE TRENDS IN THE DATA SUGGEST THAT EXPOSURE TO YOGA MAY CONVEY A SUSTAINED POSITIVE EFFECT ON DEPRESSION, RUMINATIONS, STRESS, ANXIETY, AND HEALTH-RELATED QUALITY OF LIFE. WHETHER AN INDIVIDUAL CONTINUES WITH YOGA PRACTICE, SIMPLE EXPOSURE TO A YOGA INTERVENTION APPEARS TO PROVIDE SUSTAINED BENEFITS TO THE INDIVIDUAL. THIS IS IMPORTANT BECAUSE IT IS RARE THAT ANY INTERVENTION, PHARMACOLOGIC OR NON-PHARMACOLOGIC, FOR DEPRESSION CONVEYS SUCH SUSTAINED EFFECTS FOR INDIVIDUALS WITH MDD, PARTICULARLY AFTER THE TREATMENT IS DISCONTINUED.	2014	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
12  733  50 EFFECT OF MULA BANDHA YOGA IN MILD GRADE PELVIC ORGAN PROLAPSE: A RANDOMIZED CONTROLLED TRIAL. BACKGROUND: PELVIC ORGAN PROLAPSE IS THE GROWING HEALTH ISSUE RELATED TO WOMEN OF THE REPRODUCTIVE AND POSTMENOPAUSAL AGE GROUP IN INDIA AND ACROSS THE GLOBE. TREATMENT OPTION FOR PELVIC ORGAN PROLAPSE INCLUDES BOTH SURGICAL AND NON-SURGICAL INTERVENTION. THE DEVELOPMENT OF PELVIC ORGAN PROLAPSE IS AN INDICATION FOR MAJOR SURGERY AMONG 20% OF ALL WOMEN. NEVERTHELESS, THE RECURRENCE OF PELVIC ORGAN PROLAPSE IS DETECTED AMONG 58% OF THE PATIENT AFTER SURGERY. THIS HIGHLIGHTS THE NEED FOR PREVENTIVE MEASURES FOR REDUCING THE IMPACT OF PELVIC ORGAN PROLAPSE. AIMS AND OBJECTIVE: TO STUDY THE EFFECT OF 3 MONTHS YOGA THERAPY IN FEMALE PATIENTS SUFFERING FROM MILD PELVIC ORGAN PROLAPSE. MATERIAL AND METHODS: 50 PARTICIPANTS WERE ALLOCATED INTO TWO GROUPS (25 IN EACH GROUP) BY GENERATING RANDOM ALLOCATION SEQUENCE. WOMEN AGED 20-60 WITH SYMPTOMATIC MILD PELVIC ORGAN PROLAPSE IN THE YOGA GROUP WERE OFFERED MULABANDHA YOGA THERAPY ALONG WITH OTHER CONVENTIONAL TREATMENT MODALITIES, WHILE THE CONTROL GROUP WAS ONLY ON CONVENTIONAL TREATMENT. ALL PARTICIPANTS GAVE WRITTEN INFORMED CONSENT. AN ASSESSMENT WAS DONE BY IMPROVEMENT IN CHIEF COMPLAINTS AND PELVIC FLOOR DISTRESS INVENTORY-20 (PFDI-20) & PELVIC FLOOR IMPACT QUESTIONNAIRE-7 (PFIQ-7) AT BASELINE AND AT THE END OF 4, 8 & 12 WEEKS. RESULTS AT THE END OF 12 WEEKS, POST-STUDY COMPARISON BETWEEN THE TWO GROUPS SHOWED A SIGNIFICANT IMPROVEMENT IN CHIEF COMPLAINTS LIKE PERENNIAL PAIN, P/V DISCHARGE, PERINEAL MUSCLE LAXITY AND FEELING OF SOMETHING COMING OUT P/V (P < 0.001). PARTICIPANTS IN THE YOGA GROUP IMPROVED BY (ON AVERAGE) 5.7 (95% CONFIDENCE INTERVAL 3.1 TO 14.7) POINTS MORE ON THE PFDI-20 THAN DID PARTICIPANTS IN THE CONTROL GROUP (P = 0.1) AND A MEAN SCORE OF PFIQ-7 WAS ALSO IMPROVED SIGNIFICANTLY. CONCLUSIONS: ALTHOUGH MULABANDHA (ROOT LOCK) YOGA THERAPY LED TO A SIGNIFICANTLY GREATER IMPROVEMENT IN PFDI-20 & PFIQ-7 SCORES THE DIFFERENCE BETWEEN THE GROUPS WAS BELOW THE PRESUMED LEVEL OF CLINICAL RELEVANCE (15 POINTS). MORE STUDIES ARE NEEDED TO IDENTIFY FACTORS RELATED TO THE SUCCESS OF MULABANDHA (ROOT LOCK) YOGA THERAPY AND TO INVESTIGATE LONG-TERM EFFECTS.	2018	
                                                                                                                                                                                                                                                                                                              
13 2729  39 YOGA OF AWARENESS PROGRAM FOR MENOPAUSAL SYMPTOMS IN BREAST CANCER SURVIVORS: RESULTS FROM A RANDOMIZED TRIAL. GOAL OF WORK: BREAST CANCER SURVIVORS HAVE LIMITED OPTIONS FOR THE TREATMENT OF HOT FLASHES AND RELATED SYMPTOMS. FURTHER, THERAPIES WIDELY USED TO PREVENT RECURRENCE IN SURVIVORS, SUCH AS TAMOXIFEN, TEND TO INDUCE OR EXACERBATE MENOPAUSAL SYMPTOMS. THE AIM OF THIS PRELIMINARY, RANDOMIZED CONTROLLED TRIAL WAS TO EVALUATE THE EFFECTS OF A YOGA INTERVENTION ON MENOPAUSAL SYMPTOMS IN A SAMPLE OF SURVIVORS OF EARLY-STAGE BREAST CANCER (STAGES IA-IIB). MATERIALS AND METHODS: THIRTY-SEVEN DISEASE-FREE WOMEN EXPERIENCING HOT FLASHES WERE RANDOMIZED TO THE 8-WEEK YOGA OF AWARENESS PROGRAM (GENTLE YOGA POSES, MEDITATION, AND BREATHING EXERCISES) OR TO WAIT-LIST CONTROL. THE PRIMARY OUTCOME WAS DAILY REPORTS OF HOT FLASHES COLLECTED AT BASELINE, POSTTREATMENT, AND 3 MONTHS AFTER TREATMENT VIA AN INTERACTIVE TELEPHONE SYSTEM. DATA WERE ANALYZED BY INTENTION TO TREAT. MAIN RESULTS: AT POSTTREATMENT, WOMEN WHO RECEIVED THE YOGA PROGRAM SHOWED SIGNIFICANTLY GREATER IMPROVEMENTS RELATIVE TO THE CONTROL CONDITION IN HOT-FLASH FREQUENCY, SEVERITY, AND TOTAL SCORES AND IN LEVELS OF JOINT PAIN, FATIGUE, SLEEP DISTURBANCE, SYMPTOM-RELATED BOTHER, AND VIGOR. AT 3 MONTHS FOLLOW-UP, PATIENTS MAINTAINED THEIR TREATMENT GAINS IN HOT FLASHES, JOINT PAIN, FATIGUE, SYMPTOM-RELATED BOTHER, AND VIGOR AND SHOWED ADDITIONAL SIGNIFICANT GAINS IN NEGATIVE MOOD, RELAXATION, AND ACCEPTANCE. CONCLUSIONS: THIS PILOT STUDY PROVIDES PROMISING SUPPORT FOR THE BENEFICIAL EFFECTS OF A COMPREHENSIVE YOGA PROGRAM FOR HOT FLASHES AND OTHER MENOPAUSAL SYMPTOMS IN EARLY-STAGE BREAST CANCER SURVIVORS.	2009	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
14 1682  53 ONLINE YOGA IN MYELOPROLIFERATIVE NEOPLASM PATIENTS: RESULTS OF A RANDOMIZED PILOT TRIAL TO INFORM FUTURE RESEARCH. BACKGROUND: MYELOPROLIFERATIVE NEOPLASM (MPN) PATIENTS SUFFER FROM SIGNIFICANT SYMPTOMS, INFLAMMATION AND REDUCED QUALITY OF LIFE. YOGA IMPROVES THESE OUTCOMES IN OTHER CANCERS, BUT THIS HASN'T BEEN DEMONSTRATED IN MPNS. THE PURPOSE OF THIS STUDY WAS TO: (1) EXPLORE THE LIMITED EFFICACY (DOES THE PROGRAM SHOW PROMISE OF SUCCESS) OF A 12-WEEK ONLINE YOGA INTERVENTION AMONG MPN PATIENTS ON SYMPTOM BURDEN AND QUALITY OF LIFE AND (2) DETERMINE FEASIBILITY (PRACTICALITY: TO WHAT EXTENT A MEASURE CAN BE CARRIED OUT) OF REMOTELY COLLECTING INFLAMMATORY BIOMARKERS. METHODS: PATIENTS WERE RECRUITED NATIONALLY AND RANDOMIZED TO ONLINE YOGA (60 MIN/WEEK OF YOGA) OR WAIT-LIST CONTROL (ASKED TO MAINTAIN NORMAL ACTIVITY). WEEKLY YOGA MINUTES WERE COLLECTED WITH CLICKY (ONLINE WEB ANALYTICS TOOL) AND SELF-REPORT. THOSE IN ONLINE YOGA COMPLETED A BLOOD DRAW AT BASELINE AND WEEK 12 TO ASSESS INFLAMMATION (INTERLEUKIN-6, TUMOR NECROSIS FACTOR-ALPHA [TNF-ALPHA]). ALL PARTICIPANTS COMPLETED QUESTIONNAIRES ASSESSING DEPRESSION, ANXIETY, FATIGUE, PAIN, SLEEP DISTURBANCE, SEXUAL FUNCTION, TOTAL SYMPTOM BURDEN, GLOBAL HEALTH, AND QUALITY OF LIFE AT BASELINE, WEEK SEVEN, 12, AND 16. CHANGE FROM BASELINE AT EACH TIME POINT WAS COMPUTED BY GROUP AND EFFECT SIZES WERE CALCULATED. PRE-POST INTERVENTION CHANGE IN INFLAMMATION FOR THE YOGA GROUP WAS COMPARED BY T-TEST. RESULTS: SIXTY-TWO MPN PATIENTS ENROLLED AND 48 COMPLETED THE INTERVENTION (ONLINE YOGA = 27; CONTROL GROUP = 21). YOGA PARTICIPATION AVERAGED 40.8 MIN/WEEK VIA CLICKY AND 56.1 MIN/WEEK VIA SELF-REPORT. SMALL/MODERATE EFFECT SIZES WERE GENERATED FROM THE YOGA INTERVENTION FOR SLEEP DISTURBANCE (D = - 0.26 TO - 0.61), PAIN INTENSITY (D = - 0.34 TO - 0.51), ANXIETY (D = - 0.27 TO - 0.37), AND DEPRESSION (D = - 0.53 TO - 0.78). A TOTAL OF 92.6 AND 70.4% OF ONLINE YOGA PARTICIPANTS COMPLETED THE BLOOD DRAW AT BASELINE AND WEEK 12, RESPECTIVELY, AND THERE WAS A DECREASE IN TNF-ALPHA FROM BASELINE TO WEEK 12 (- 1.3 +/- 1.5 PG/ML). CONCLUSIONS: ONLINE YOGA DEMONSTRATED SMALL EFFECTS ON SLEEP, PAIN, AND ANXIETY AS WELL AS A MODERATE EFFECT ON DEPRESSION. REMOTE BLOOD DRAW PROCEDURES ARE FEASIBLE AND THE EFFECT SIZE OF THE INTERVENTION ON TNF-ALPHA WAS LARGE. FUTURE FULLY POWERED RANDOMIZED CONTROLLED TRIALS ARE NEEDED TO TEST FOR EFFICACY. TRIAL REGISTRATION: THIS TRIAL WAS RETROSPECTIVELY REGISTERED WITH CLINICALTRIALS.GOV (ID: NCT03503838 ) ON 4/19/2018.	2019	

15 2643  26 YOGA FOR WOMEN WITH METASTATIC BREAST CANCER: RESULTS FROM A PILOT STUDY. METASTATIC BREAST CANCER (MBC) REMAINS A TERMINAL ILLNESS FOR WHICH MAJOR TREATMENT ADVANCES ARE SLOW TO APPEAR, AND HENCE IT IS CRUCIAL THAT EFFECTIVE PALLIATIVE INTERVENTIONS BE DEVELOPED TO REDUCE THE CANCER-RELATED SYMPTOMS OF WOMEN WITH THIS CONDITION DURING THE REMAINING YEARS OF THEIR LIVES. THIS PILOT/FEASIBILITY STUDY EXAMINED A NOVEL, YOGA-BASED PALLIATIVE INTERVENTION, THE YOGA OF AWARENESS PROGRAM, IN A SAMPLE OF WOMEN WITH MBC. THE EIGHT-WEEK PROTOCOL INCLUDED GENTLE YOGA POSTURES, BREATHING EXERCISES, MEDITATION, DIDACTIC PRESENTATIONS, AND GROUP INTERCHANGE. OUTCOME WAS ASSESSED USING DAILY MEASURES OF PAIN, FATIGUE, DISTRESS, INVIGORATION, ACCEPTANCE, AND RELAXATION DURING TWO PREINTERVENTION WEEKS AND THE FINAL TWO WEEKS OF THE INTERVENTION. THIRTEEN WOMEN COMPLETED THE INTERVENTION (MEAN AGE=59; MEAN TIME SINCE DIAGNOSIS=7 YEARS; TWO AFRICAN AMERICAN, 11 CAUCASIAN). DURING THE STUDY, FOUR PARTICIPANTS HAD CANCER RECURRENCES, AND THE PHYSICAL CONDITION OF SEVERAL OTHERS DETERIORATED NOTICEABLY. DESPITE LOW STATISTICAL POWER, PRE-TO-POST MULTILEVEL OUTCOMES ANALYSES SHOWED SIGNIFICANT INCREASES IN INVIGORATION AND ACCEPTANCE. LAGGED ANALYSES OF LENGTH OF HOME YOGA PRACTICE (CONTROLLING FOR INDIVIDUAL MEAN PRACTICE TIME AND OUTCOME LEVELS ON THE LAGGED DAYS) SHOWED THAT ON THE DAY AFTER A DAY DURING WHICH WOMEN PRACTICED MORE, THEY EXPERIENCED SIGNIFICANTLY LOWER LEVELS OF PAIN AND FATIGUE, AND HIGHER LEVELS OF INVIGORATION, ACCEPTANCE, AND RELAXATION. THESE FINDINGS SUPPORT THE NEED FOR FURTHER INVESTIGATION OF THE EFFECTS OF THE YOGA OF AWARENESS PROGRAM IN WOMEN WITH MBC.	2007	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
16 2421  36 YOGA AND MINDFULNESS AS A TOOL FOR INFLUENCING AFFECTIVITY, ANXIETY, MENTAL HEALTH, AND STRESS AMONG HEALTHCARE WORKERS: RESULTS OF A SINGLE-ARM CLINICAL TRIAL. MINDFULNESS-BASED INTERVENTIONS HAVE EMERGED AS UNIQUE APPROACHES FOR ADDRESSING A RANGE OF CLINICAL AND SUBCLINICAL DIFFICULTIES SUCH AS STRESS, CHRONIC PAIN, ANXIETY, OR RECURRENT DEPRESSION. MOREOVER, THERE IS STRONG EVIDENCE ABOUT THE POSITIVE EFFECTS OF YOGA PRACTICE ON STRESS MANAGEMENT AND PREVENTION OF BURNOUT AMONG HEALTHCARE WORKERS. THE AIM OF THIS STUDY WAS TO CONDUCT A SINGLE-ARM CLINICAL TRIAL TO ASSESS THE EFFECTIVENESS OF AN INTERVENTION BASED ON MINDFULNESS-BASED STRESS REDUCTION AND YOGA IN IMPROVING HEALTHCARE WORKERS' QUALITY OF LIFE. HEALTHCARE WORKERS OF TWO HOSPITALS IN ROME WERE ENROLLED IN A 4-WEEK YOGA AND MINDFULNESS COURSE. FOUR QUESTIONNAIRES WERE ADMINISTERED AT DIFFERENT TIMES (SHORT FORM-12 (SF-12), STATE-TRAIT ANXIETY INVENTORY (STAI) Y1 AND Y2, AND POSITIVE AND NEGATIVE AFFECT SCHEDULE (PANAS)) TO EVALUATE THE EFFICACY OF THE INTERVENTION. FORTY PARTICIPANTS TOOK PART TO THE STUDY (83.3 %). THE MENTAL COMPOSITE SCORE-12, THAT IS PART OF THE QUALITY OF LIFE ASSESSMENT, PASSED FROM A MEDIAN OF 43.5 PREINTERVENTION TO 48.1 POSTINTERVENTION (P = 0.041), AND THE NEGATIVE AFFECT PASSED FROM A SCORE OF 16 IN THE PREINTERVENTION TO 10 IN THE POSTINTERVENTION (P < 0.001). BOTH THE FORMS OF THE STAI QUESTIONNAIRES SHOWED A DECREASE AFTER THE INTERVENTION. YOGA AND MINDFULNESS ADMINISTERED TOGETHER SEEM TO BE EFFECTIVE TO REDUCE STRESS AND ANXIETY IN HEALTHCARE WORKERS, PROVIDING THEM WITH MORE CONSCIOUSNESS AND ABILITY TO MANAGE WORK STRESSFUL DEMANDS.	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
17 2783  36 YOGA THERAPY AS AN ADJUNCT TO CONVENTIONAL MANAGEMENT OF SYSTEMIC SCLEROSIS: A CASE SERIES. SYSTEMIC SCLEROSIS (SSC) IS AN AUTOIMMUNE DISORDER LEADING TO SIGNIFICANT DISABILITY AND LOSS OF QUALITY OF LIFE (QOL). YOGA HAS BECOME POPULAR IN RECENT TIMES FOR ITS POTENTIAL THERAPEUTIC BENEFITS. SINCE THERE ARE NO SCIENTIFIC REPORTS ON THE USE OF YOGA FOR SSC, WE PRESENT TWO FEMALE CASES (AGED 49 AND 29 RESPECTIVELY) OF LIMITED SSC (DURATION OF ILLNESS 4 AND 3 YEARS RESPECTIVELY) WHO UNDERWENT YOGA THERAPY AS AN ADJUNCT TO CONVENTIONAL MANAGEMENT IN A RESIDENTIAL SETTING FOR A PERIOD OF FIVE AND FOUR WEEKS, RESPECTIVELY. DURING THEIR STAY, THEY UNDERWENT A SPECIFICALLY DESIGNED YOGA MODULE. AFTER THEIR DISCHARGE, THEY WERE FOLLOWED-UP FOR FOUR WEEKS, DURING WHICH THEY WERE ASKED TO CONTINUE PRACTICING YOGA FOR 1 H EVERY DAY. BOTH OF THEM REPORTED A REDUCTION IN PAIN, STIFFNESS, SYMPTOM SCORES, AND IMPROVED QOL ON DISCHARGE AND AT THE FOLLOW-UP COMPARED TO THE VALUES ON ADMISSION. ERYTHROCYTE SEDIMENTATION RATE (ESR) AND C-REACTIVE PROTEIN (CRP), AS BIOMARKERS OF INFLAMMATION, REDUCED ON THE DISCHARGE WHEN COMPARED TO THE BASELINE. NO ADVERSE EVENTS WERE NOTED DURING THE STAY AND THE FOLLOW-UP. THUS, THE PRESENT CASE SERIES INDICATE A POSSIBLE BENEFICIAL ROLE OF YOGA AS AN ADJUNCT THERAPY TO CONVENTIONAL MANAGEMENT OF SSC. FURTHER STUDIES IN THE AREA ARE WARRANTED TO ASCERTAIN THE EFFICACY OF YOGA FOR SSC.	2021	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
18 1923  54 ROLE OF YOGA AS AN ADJUNCTIVE THERAPY IN PATIENTS WITH NEUROCARDIOGENIC SYNCOPE: A PILOT STUDY. BACKGROUND: NEUROCARDIOGENIC SYNCOPE (NCS) IS A COMMON CLINICAL CONDITION CHARACTERIZED BY ABRUPT CARDIOVASCULAR AUTONOMIC CHANGES RESULTING IN SYNCOPE. THIS IS A RECURRING CONDITION WITH MIXED RESULTS FROM CURRENT STRATEGIES OF TREATMENT. METHODS: SUBJECTS WITH A DIAGNOSIS OF NCS WERE SCREENED AND ENROLLED. ALL THE PARTICIPANTS WERE GIVEN A DVD CONTAINING YOGA VIDEOS AND WERE INSTRUCTED TO PRACTICE YOGA THERAPY FOR 60 MIN, THREE TIMES A WEEK FOR 3 CONSECUTIVE MONTHS. SYNCOPE FUNCTIONAL STATUS QUESTIONNAIRE SCORE (SFSQS) WAS ADMINISTERED AT THE BEGINNING AND THE END OF THE STUDY. THE SUBJECTS WERE FOLLOWED FOR 3 MONTHS AND UNDERWENT REPEAT TILT TABLE TESTING AT THE END OF THE STUDY. RESULTS: OF THE 60 PATIENTS SCREENED, 44 SUBJECTS WERE ENROLLED, 21 IN THE INTERVENTION GROUP AND 23 IN THE CONTROL GROUP. MOST OF THE PARTICIPANTS WERE FEMALES, AND THE MEAN AGE WAS 21 +/- 3 YEARS. IN THE INTERVENTION GROUP, WHO FINISHED THE YOGA REGIMEN, THERE WAS A STATISTICALLY SIGNIFICANT IMPROVEMENT FROM CONTROL PHASE TO THE INTERVENTION PHASE, IN NUMBER OF EPISODES OF SYNCOPE (4 +/- 1 VS 1.3 +/- 0.7, P < 0.001) AND PRESYNCOPE (4.7 +/- 1.5 VS 1.5 +/- 0.5, P < 0.001). THE MEAN SFSQS ALSO DECREASED FROM 67 +/- 7.8 TO 29.8 +/- 4.6 (P < 0.001). ALL SUBJECTS HAD POSITIVE HEAD UP TILT TABLE (HUTT) STUDY AT THE TIME OF ENROLLMENT COMPARED TO ONLY SIX PATIENTS AT THE COMPLETION OF INTERVENTION PHASE (10/100 VS 6/28 %, P < 0.0001). CONCLUSION: YOGA THERAPY CAN POTENTIALLY IMPROVE THE SYMPTOMS OF PRESYNCOPE AND SYNCOPE IN YOUNG FEMALE PATIENTS WITH NCS.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
19 2412  24 YOGA AND ITS IMPACT ON CHRONIC INFLAMMATORY AUTOIMMUNE ARTHRITIS. RHEUMATOID ARTHRITIS (RA) IS ONE OF THE MOST COMMON CHRONIC INFLAMMATORY AUTOIMMUNE DISEASES, WHICH ADVERSELY AFFECTS THE QUALITY OF LIFE. RA IS A DISEASE OF UNKNOWN ETIOLOGY, HOWEVER, BOTH GENETIC AND ENVIRONMENTAL FACTORS APPEAR TO CONTRIBUTE TO THE SUSCEPTIBILITY TO THIS DISEASE. THE SEVERITY AND PROGRESSION OF THE DISEASE ARE ATTRIBUTABLE TO THE RELEASE OF A HOST OF INFLAMMATORY CYTOKINES, CYTOTOXIC AND IMMUNE REGULATORY FACTORS. THE TREATMENTS OF RA ARE PRIMARILY LIMITED TO SYMPTOMATIC ALLEVIATION OF PAIN OR OTHER SYMPTOMS OR TO THE USE OF CYTOTOXIC DRUG TREATMENT IN SEVERE FORMS OF THE DISEASE WHICH IS COMMONLY ASSOCIATED WITH SIGNIFICANT SIDE EFFECTS. DESPITE LACK OF A CURE, THE DISEASE MAY BE CONTROLLED BY MIND-BODY INTERVENTIONS. HOLISTIC TREATMENTS SUCH AS YOGA SIGNIFICANTLY IMPROVE AND REDUCE THE PSYCHO-SOMATIC SYMPTOMS, PAIN PERCEPTION, DISABILITY QUOTIENT, JOINT FLEXIBILITY, RANGE OF MOTION, POSTURE, MUSCLE STRENGTH, COORDINATION, AND DISEASE ACTIVITY. HERE, WE DISCUSS THE FEATURES OF RA AND ADDRESS HOW YOGA CAN BE USED AS A THERAPEUTIC REGIMEN TO IMPROVE THE QUALITY OF LIFE OF PATIENTS WITH RA.	2021	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
20  252  34 A YOGA PROGRAM FOR THE SYMPTOMS OF POST-TRAUMATIC STRESS DISORDER IN VETERANS. THE PURPOSE OF THIS PILOT STUDY WAS TO EVALUATE THE FEASIBILITY AND EFFECTIVENESS OF A YOGA PROGRAM AS AN ADJUNCTIVE THERAPY FOR IMPROVING POST-TRAUMATIC STRESS DISORDER (PTSD) SYMPTOMS IN VETERANS WITH MILITARY-RELATED PTSD. VETERANS (N = 12) PARTICIPATED IN A 6 WEEK YOGA INTERVENTION HELD TWICE A WEEK. THERE WAS SIGNIFICANT IMPROVEMENT IN PTSD HYPERAROUSAL SYMPTOMS AND OVERALL SLEEP QUALITY AS WELL AS DAYTIME DYSFUNCTION RELATED TO SLEEP. THERE WERE NO SIGNIFICANT IMPROVEMENTS IN THE TOTAL PTSD, ANGER, OR QUALITY OF LIFE OUTCOME SCORES. THESE RESULTS SUGGEST THAT THIS YOGA PROGRAM MAY BE AN EFFECTIVE ADJUNCTIVE THERAPY FOR IMPROVING HYPERAROUSAL SYMPTOMS OF PTSD INCLUDING SLEEP QUALITY. THIS STUDY DEMONSTRATES THAT THE YOGA PROGRAM IS ACCEPTABLE, FEASIBLE, AND THAT THERE IS GOOD ADHERENCE IN A VETERAN POPULATION.	2013