1 821 90 EFFECT OF YOGA ON EXERCISE TOLERANCE IN NORMAL HEALTHY VOLUNTEERS. TWELVE NORMAL HEALTHY VOLUNTEERS (6 MALES AND 6 FEMALES) UNDERGOING YOGA TRAINING FOR 90 DAYS WERE STUDIED FOR THE EFFECT OF YOGA ON EXERCISE TOLERANCE. THEIR AGES RANGED FROM 18 TO 28 YEARS. THE VOLUNTEERS WERE TAUGHT ONLY PRANAYAMA FOR THE FIRST 20 DAYS AND LATER ON YOGIC ASANAS WERE ADDED. SUB-MAXIMAL EXERCISE TOLERANCE TEST WAS DONE ON A MOTORIZED TREADMILL BY USING BALKE'S MODIFIED PROTOCOL, INITIALLY, AFTER 20 DAYS (PHASE-I) AND AFTER 90 DAYS OF YOGA TRAINING (PHASE-II). PYRUVATE AND LACTATE IN VENOUS BLOOD AND BLOOD GASES IN CAPILLARY BLOOD WERE ESTIMATED IMMEDIATELY BEFORE AND AFTER THE EXERCISE. MINUTE VENTILATION AND OXYGEN CONSUMPTION WERE ESTIMATED BEFORE AND DURING THE TEST. POST EXERCISE BLOOD LACTATE WAS ELEVATED SIGNIFICANTLY DURING INITIAL AND PHASE-I, BUT NOT IN PHASE-II. THERE WAS SIGNIFICANT REDUCTION OF MINUTE VENTILATION AND OXYGEN CONSUMPTION ONLY IN MALES IN PHASE-I AND II AT THE TIME WHEN THE VOLUNTEERS REACHED THEIR 80% OF THE PREDICTED HEART RATE. FEMALE VOLUNTEERS WERE ABLE TO GO TO HIGHER LOADS OF EXERCISE IN PHASE-I AND II. 1986 2 2874 11 YOGA-INDUCED UVEITIS GLAUCOMA HYPHEMA SYNDROME. A 74-YEAR-OLD PSEUDOPHAKIC WHITE WOMAN WITH PSEUDOEXFOLIATION SYNDROME PRESENTED WITH RIGHT EYE PAIN AND PHOTOPHOBIA AND WAS FOUND TO HAVE PSEUDOPHACODENESIS WITH RECURRENT EPISODES OF ANTERIOR UVEITIS, MICROHYPHEMA, AND ELEVATED INTRAOCULAR PRESSURE (IOP). ALL EPISODES OCCURRED AFTER YOGA SESSIONS WITH INTENSIVE FACEDOWN POSTURES. ULTRASOUND BIOMICROSCOPY (UBM) PERFORMED IN SUPINE AND PRONE POSITIONS DEMONSTRATED SIGNIFICANT CHANGE IN THE LENS-BAG COMPLEX POSITION, WITH LENS-IRIS TOUCH. THE PATIENT UNDERWENT INTRAOCULAR LENS (IOL) EXPLANTATION, ANTERIOR VITRECTOMY, AND FLANGED INTRASCLERAL HAPTIC-FIXATED IOL PLACEMENT VIA DOUBLE-NEEDLE TECHNIQUE, WITH RESOLUTION OF ALL SYMPTOMS. 2021 3 1326 6 HIGH FREQUENCY YOGA BREATHING INCREASES ENERGY -EXPENDITURE FROM CARBOHYDRATES. COMMENT TO: ASSESSMENT OF SLEEP PATTERNS, ENERGY EXPENDITURE AND CIRCADIAN RHYTHMS OF SKIN TEMPERATURE IN PATIENTS WITH ACUTE CORONARY SYNDROME HADIL AL OTAIR, MUSTAFA AL-SHAMIRI, MOHAMMED BAHOBAIL, MUNIR M. SHARIF, AHMED S. BAHAMMAM MED SCI MONIT, 2011; 17(7): CR397-403. 2011 4 379 15 BASILAR ARTERY OCCLUSION FOLLOWING YOGA EXERCISE: A CASE REPORT. BASILAR ARTERY OCCLUSION DEVELOPED IN A 34 YEAR OLD WOMAN 2 MONTHS AFTER ADOPTING UNUSUAL NECK POSTURES DURING YOGA PRACTICE. ON ANGIOGRAPHY, HER BASILAR ARTERY WAS FILLED WITH INTRALUMINAL CLOT WHILE THE VERTEBRAL ARTERIES WERE NORMAL. WE POSTULATE THAT A SEVERE REDUCTION IN BLOOD FLOW AND POSSIBLY AN INTIMAL TEAR TRIGGERED THROMBOSIS OF THE VERTEBRAL ARTERY AND THAT THE FINAL STROKE MECHANISM WAS ARTERY-TO-ARTERY EMBOLISM. 1993 5 52 12 A COMPARATIVE STUDY OF BILVADI YOGA ASHCHYOTANA AND EYE DROPS IN VATAJA ABHISHYANDA (SIMPLE ALLERGIC CONJUNCTIVITIS). SIMPLE ALLERGIC CONJUNCTIVITIS IS THE MOST COMMON FORM OF OCULAR ALLERGY (PREVALENCE 5 - 22 %). IT IS A HYPERSENSITIVITY REACTION TO SPECIFIC AIRBORNE ANTIGENS. THE DISEASE VATAJA ABHISHYANDA, WHICH IS DUE TO VITIATION OF VATA PRADHANA TRIDOSHA IS COMPARABLE WITH THIS CONDITION. THE MANAGEMENT OF SIMPLE ALLERGIC CONJUNCTIVITIS IN MODERN OPHTHALMOLOGY IS VERY EXPENSIVE AND IT SHOULD BE FOLLOWED LIFELONG AND AYURVEDA CAN PROVIDE BETTER RELIEF IN SUCH MANIFESTATION. THIS IS THE FIRST RESEARCH STUDY ON VATAJA ABHISHYANDA. PATIENTS WERE SELECTED FROM THE OUTPATIENT DEPARTMENT (OPD), INPATIENT DEPARTMENT (IPD), OF THE SHALAKYA TANTRA DEPARTMENT AND WERE RANDOMLY DIVIDED INTO TWO GROUPS. IN GROUP-A BILVADI ASHCHYOTANA AND IN GROUP-B BILVADI EYE DROPS WERE INSTILLED FOR THREE MONTHS. TOTAL 32 PATIENTS WERE REGISTERED AND 27 PATIENTS COMPLETED THE COURSE OF TREATMENT. BILVADI ASHCHYOTANA GAVE BETTER RESULTS IN TODA, SANGHARSHA, PARUSHYA, KANDU AND RAGATA AS COMPARED WITH BILVADI EYE DROPS IN VATAJA ABHISHYANDA. 2012 6 1736 20 PHOTO URTICARIA CAUSED BY EXPOSURE TO LED EMITTING 633-NM WAVELENGTH DURING HOT YOGA EXERCISE. PHOTO URTICARIA (PU) IS A RARE TYPE OF URTICARIA THAT DEVELOPS AFTER EXPOSURE TO VARIOUS WAVELENGTHS OF LIGHT. INDUCING URTICARIAL WHEALS USING LIGHT SOURCES OF PERTINENT WAVELENGTHS CAN HELP MAKE THE DEFINITIVE DIAGNOSIS OF PU. THE ACTION SPECTRA (AS) IN JAPANESE PATIENTS WITH PU COMMONLY FALL WITHIN THE ULTRAVIOLET RADIATION A AND VISIBLE LIGHT RANGE. HEREIN, TO THE BEST OF OUR KNOWLEDGE, WE PRESENT THE FIRST CASE OF PU CAUSED BY 633-NM WAVELENGTH WITHIN THE VISIBLE LIGHT SPECTRUM. OUR PATIENT WORKED AS A "HOT YOGA" INSTRUCTOR, WHERE LIGHT-EMITTING DIODES (LEDS) ON THE CEILING WERE USED TO IRRADIATE THE ENTIRE ROOM WITH 633-NM WAVELENGTH OF LIGHT FOR "LIGHT TREATMENT." SHE REPORTED ITCHING AND WHEALS ON THE FACE AND NECK DURING HER "HOT YOGA" SESSIONS. "HOT YOGA" HAS RECENTLY GAINED POPULARITY GLOBALLY. THE "LIGHT TREATMENT" IS BASED ON THE THEORY THAT 633-NM WAVELENGTH LIGHT WITHIN THE VISIBLE LIGHT SPECTRUM REPORTEDLY PREVENTS THE SKIN FROM AGING. WE INDUCED WHEALS WITH ERYTHEMA BY IRRADIATING HER SKIN USING A 633-NM LED AT A DOSE OF 0.008 J/CM(2) /S FOR 1 H. HER CONDITION WAS DIAGNOSED AS PU CAUSED BY EXPOSURE TO 633 NM. LIGHT. HER SYMPTOMS HAVE NOT RECURRED SINCE SHE HAS AVOIDED BEING EXPOSED TO THE 633-NM WAVELENGTH OF LED LIGHT. 2021 7 2289 9 THE YOGA OF RAG GTPASES: DYNAMIC STRUCTURAL POSES CONFER AMINO ACID SENSING BY MTORC1. HETERODIMERIC RAG GTPASES PLAY A CRITICAL ROLE IN RELAYING FLUCTUATING LEVELS OF CELLULAR AMINO ACIDS TO THE SENSOR MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1. IMPORTANT MECHANISTIC QUESTIONS REMAIN UNRESOLVED, HOWEVER, REGARDING HOW GUANINE NUCLEOTIDE BINDING ENABLES RAG GTPASES TO TRANSITION DYNAMICALLY BETWEEN DISTINCT YOGA-LIKE STRUCTURAL POSES THAT CONTROL ACTIVATION STATE. EGRI AND SHEN IDENTIFIED A CRITICAL INTERDOMAIN HYDROGEN BOND WITHIN RAGA AND RAGC THAT STABILIZES THEIR GDP-BOUND STATES. THEY DEMONSTRATE THAT THIS LONG-DISTANCE INTERACTION CONTROLS RAG STRUCTURE AND FUNCTION TO CONFER APPROPRIATE AMINO ACID SENSING BY MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1. 2021 8 482 15 CLINICAL EFFICACY OF HERBAL PADMAPATRADI YOGA IN BRONCHIAL ASTHMA (TAMAKA SWASA). AYURVEDA REFERS TO BRONCHIAL ASTHMA AS TAMAKA SWASA AND IT IS WELL EXPLAINED IN CHARAKA SAMHITA. IT CONTRIBUTES SEVERAL MODALITIES OF THE TREATMENT FOR SWASA ROGA(ASTHMA). AMONG ALL MODALITIES OF TREATMENT, POLYHERBAL COMBINATIONS ARE SAID TO BE WELL-ACCEPTED, SAFE AND EFFECTIVE IN ASTHMA. A STUDY WAS CARRIED OUT IN 40 PATIENTS OF EITHER SEX IN BETWEEN THE AGE OF 15-65 YEARS TO ASSURE THE CLINICAL RESPONSE OF PADMAPATRADI YOGA IN BRONCHIAL ASTHMA (TAMAKA SWASA) AT P.G. DEPARTMENT OF KAYACHIKITSA, D.G.M. AYURVEDIC MEDICAL COLLEGE, GADAG, KARNATAKA. THE SUM TOTAL PROPERTIES OF PADMAPATRADI YOGA IS TIKTA KATU RASA, LAGHU AND TIKNA GUNA (LIGHT AND PENETRATING PROPERTIES), USHNA VIRYA (HOT POTENCY) AND VATAKAPHAGNA (DECREASE VATA AND KAPHA DOSA) PADMAPATRADI YOGA IS EFFECTIVE IN INCREASED PEAK EXPIRATORY FLOW RATE, BREATH HOLDING TIME, AND REDUCES THE ABSOLUTE EOSINOPHIL COUNT OF STUDIED CASES AND ALSO FOUND STATISTICALLY HIGHLY SIGNIFICANT AT P<0.001 LEVEL. THE DRUG IS QUITE SAFE AND ACTS AS A BRONCHODILATOR, ANTIHISTAMINIC AND ANTI-INFLAMMATORY. 2011 9 49 13 A COMPARATIVE CLINICAL STUDY OF SHATAPATRAYADI CHURNA TABLET AND PATOLADI YOGA IN THE MANAGEMENT OF AMLAPITTA. AMLAPITTA IS A VERY COMMON DISEASE CAUSED BY VIDAGDHA PITTA WITH FEATURES SUCH AS AMLODGARA, HRID KANTHA DAHA, AND AVIPAKA. THIS IS A BURNING PROBLEM OF THE SOCIETY. IRREGULAR AND IMPROPER FOOD HABITS, AND BUSY STRESSFUL LIFESTYLE IS ONE OF THE MAIN CULPRIT. AMLAPITTA IS THE GI DISORDER DESCRIBED IN AYURVEDIC TEXTS THAT CLOSELY RESEMBLES WITH GASTRITIS IN MODERN SCIENCE. IN CHRONIC STAGE, IT MAY LEAD TO ULCERATIVE CONDITIONS. IN THIS STUDY, TOTAL 41 PATIENTS WERE REGISTERED AND WERE RANDOMLY DIVIDED INTO TWO GROUPS. IN GROUP A, SHATAPATRAYADICHURNA TABLET AND IN GROUP B PATOLADI YOGA TABLET WERE GIVEN FOR 1 MONTH. THE NIDANA, SIGNS, AND SYMPTOMS WERE OBSERVED CAREFULLY TO GET IDEA ABOUT THE SAMPRAPTI OF THE DISEASE. THE EFFECT OF PATOLADI YOGA ON ROGA BALA IS 65.79%, 62.11% ON AGNI BALA, AND 63.35% ON DEHA AND CHETASA BALA. THE OVERALL RELIEF WAS 63.75%. THE EFFECT OF SHATAPATRAYADI TABLET ON ROGA BALA WAS 71.94%, 73.15% ON AGNI BALA, AND 77.68% ON DEHA AND CHETAS BALA. THE OVERALL RELIEF WAS 74.25%. 2011 10 1685 8 OPTICAL TOPOGRAPHY RECORDING OF CORTICAL ACTIVITY DURING HIGH FREQUENCY YOGA BREATHING AND BREATH AWARENESS. COMMENT TO: NON-INVASIVE ASSESSMENT OF HEMISPHERIC LANGUAGE DOMINANCE BY OPTICAL TOPOGRAPHY DURING A BRIEF PASSIVE LISTENING TEST: A PILOT STUDY. STEFANO BEMBICH, SERGIO DEMARINI, ANDREA CLARICI, STEFANO MASSACCESI, DOMENICO GRASSO. MED SCI MONIT 2011; 17(12): CR692-697. 2012 11 1323 25 HEMODYNAMIC OBSERVATIONS OF TUMO YOGA PRACTITIONERS IN A HIMALAYAN ENVIRONMENT. BACKGROUND: FEW ATTEMPTS HAVE BEEN MADE TO EVALUATE THE PHYSIOLOGY OF TRADITIONAL EASTERN HEALTH PRACTICES. THE GOAL OF THIS STUDY WAS TO EVALUATE THE HEMODYNAMIC EFFECTS OF THE MYSTERIOUS BUDDHIST PRACTICE OF TUMO. TUMO IS A MEDITATIVE PRACTICE THAT PRODUCES INNER HEAT THROUGH THE ALLEGED CULTIVATION OF BODY ENERGY-CHANNELS. METHODS: THIS STUDY WAS PERFORMED BY MEMBERS OF AN INTERNATIONAL EXPEDITION TO THE HIMALAYAN MOUNTAINS IN THE REPUBLIC OF INDIA. THE STUDY WAS PERFORMED IN AN UNPOPULATED OUTDOOR MOUNTAINOUS AREA AT AN ALTITUDE OF 16,400 FT WITH AMBIENT TEMPERATURES BETWEEN -10 AND -15( DEGREES )C. TWO (2) COHORTS OF SUBJECTS WERE STUDIED: HEALTHY NON-YOGI VOLUNTEERS AND TUMO PRACTITIONERS. ALL OF THE SUBJECTS WERE STRIPPED DOWN TO THEIR UNDERCLOTHES AND EXPOSED TO THE SUBZERO ATMOSPHERIC TEMPERATURES FOR 5 MINUTES. THE VOLUNTEERS WERE THEN PASSIVELY REWARMED WHILE THE TUMO PRACTITIONERS PERFORMED TUMO FOR UP TO 10 MINUTES. BLOOD PRESSURE, HEART RATE, AND STROKE VOLUME INDEX (SVI) AND CARDIAC INDEX WERE MEASURED NONINVASIVELY USING A NICOM HEMODYNAMIC MONITOR, WHILE CAROTID BLOOD FLOW AND BIVENTRICULAR PERFORMANCE WERE DETERMINED ECHOCARDIOGRAPHICALLY AT EACH STAGE OF THE EXPERIMENT. THE TOTAL PERIPHERAL RESISTANCE INDEX (TPRI), LEFT VENTRICULAR EJECTION FRACTION (LVEF), AND TRICUSPID ANNULAR PLANE SYSTOLIC EXCURSION (TAPSE) WERE DETERMINED USING STANDARD FORMULA. RESULTS: FOURTEEN (14) SUBJECTS (SIX VOLUNTEERS AND EIGHT TUMO PRACTITIONERS) COMPLETED THE STUDY. THERE WAS ONE FEMALE SUBJECT IN EACH GROUP. WITH COLD EXPOSURE, THE SVI AND CAROTID BLOOD FLOW DECREASED WHILE THE TPRI INCREASED SIGNIFICANTLY IN BOTH GROUPS. IN THE VOLUNTEER GROUP, THESE CHANGES RETUNED TO BASELINE WITH REWARMING. FOLLOWING TUMO, THE CARDIAC INDEX (4.8+/-0.6 VERSUS 4.0+/-0.5 L/M(2); P<0.01), CAROTID BLOOD FLOW (445+/-127 VERSUS 325+/-100 ML/MIN/M(2), P<0.01), LVEF (68+/-5 VERSUS 64+/-7%; P<0.05) AND TAPSE (2.9+/-0.4 VERSUS 2.4+/-0.5 CM; P<0.01) WERE SIGNIFICANTLY HIGHER WHEN COMPARED WITH BASELINE, WHILE THE TPRI WAS SIGNIFICANTLY LOWER (1786+/-189 VERSUS 2173+/-281; P<0.01). CONCLUSIONS: TUMO WAS ASSOCIATED WITH A HYPERDYNAMIC VASODILATED STATE WITH INCREASED BIVENTRICULAR PERFORMANCE. WE POSTULATE THAT TUMO RESULTS IN A MASSIVE INCREASE IN SYMPATHETIC ACTIVITY WITH ACTIVATION OF BROWN ADIPOSE TISSUE AND MARKED HEAT PRODUCTION. THE INCREASED HEAT PRODUCTION MAY EXPLAIN THE PARADOXICAL VASODILATATION IN TUMO PRACTITIONERS EXPOSED TO SUBZERO TEMPERATURES. 2014 12 885 21 EFFECT OF YOGA TRAINING ON REACTION TIME, RESPIRATORY ENDURANCE AND MUSCLE STRENGTH. THERE IS EVIDENCE THAT THE PRACTICE OF YOGA IMPROVES PHYSICAL AND MENTAL PERFORMANCE. THE PRESENT INVESTIGATION WAS UNDERTAKEN TO STUDY THE EFFECT OF YOGA TRAINING ON VISUAL AND AUDITORY REACTION TIMES (RTS), MAXIMUM EXPIRATORY PRESSURE (MEP), MAXIMUM INSPIRATORY PRESSURE (MIP), 40 MMHG TEST, BREATH HOLDING TIME AFTER EXPIRATION (BHTEXP), BREATH HOLDING TIME AFTER INSPIRATION (BHTINSP), AND HAND GRIP STRENGTH (HGS). TWENTY SEVEN STUDENT VOLUNTEERS WERE GIVEN YOGA TRAINING FOR 12 WEEKS. THERE WAS A SIGNIFICANT (P < 0.001) DECREASE IN VISUAL RT (FROM 270.0 +/- 6.20 (SE) TO 224.81 +/- 5.76 MS) AS WELL AS AUDITORY RT (FROM 194.18 +/- 6.00 TO 157.33 +/- 4.85 MS). MEP INCREASED FROM 92.61 +/- 9.04 TO 126.46 +/- 10.75 MMHG, WHILE MIP INCREASED FROM 72.23 +/- 6.45 TO 90.92 +/- 6.03 MMHG, BOTH THESE CHANGES BEING STATISTICALLY SIGNIFICANT (P < 0.05). 40 MMHG TEST AND HGS INCREASED SIGNIFICANTLY (P < 0.001) FROM 36.57 +/- 2.04 TO 53.36 +/- 3.95 S AND 13.78 +/- 0.58 TO 16.67 +/- 0.49 KG RESPECTIVELY. BHTEXP INCREASED FROM 32.15 +/- 1.41 TO 44.53 +/- 3.78S (P < 0.01) AND BHTINSP INCREASED FROM 63.69 +/- 5.38 TO 89.07 +/- 9.61 S (P < 0.05). OUR RESULTS SHOW THAT YOGA PRACTICE FOR 12 WEEKS RESULTS IN SIGNIFICANT REDUCTION IN VISUAL AND AUDITORY RTS AND SIGNIFICANT INCREASE IN RESPIRATORY PRESSURES, BREATH HOLDING TIMES AND HGS. 1992 13 1358 21 IMMEDIATE EFFECT OF YOGA EXERCISES FOR EYES ON THE MACULAR THICKNESS. BACKGROUND: YOGA EXERCISES FOR EYES HAVE BEEN ADVOCATED AS BENEFICIAL TO EYE HEALTH. IN A PREVIOUS STUDY, WE EVALUATED THE EFFECT OF YOGA EXERCISES FOR EYES ON THE INTRAOCULAR PRESSURE (IOP). THE OTHER ASPECTS OF THE EFFECTS OF YOGA EXERCISES FOR EYES TO OCULAR STRUCTURE HAVE NOT BEEN INVESTIGATED YET. AIM: THE AIM OF THIS STUDY IS TO EVALUATE THE EFFECT OF YOGA EXERCISES FOR EYES ON THE MACULAR STRUCTURE USING THE OPTICAL COHERENCE TOMOGRAPHY (OCT) AND OCT ANGIOGRAPHY (OCTA) PARAMETERS. METHODS: TWENTY-NINE PARTICIPANTS WERE INCLUDED IN THIS MASKED WITHIN PARTICIPANT COMPARISON OF HEALTHY CONTROLS. BASIC OPHTHALMIC EXAMINATION WAS PERFORMED, AFTER WHICH PATIENTS WERE EVALUATED FOR IOP, OCT, AND OCTA BEFORE AND AFTER YOGA EXERCISES FOR EYES. OCT/A PARAMETERS THAT WERE EVALUATED WERE: AVERAGE MACULAR THICKNESS (AMT) (MUM), CENTRAL MACULAR THICKNESS (MUM), CENTRAL CHOROIDAL THICKNESS (MUM) VESSEL DENSITY (%) IN THE SUPERFICIAL, DEEP VASCULAR LAYERS, AND IN THE CHORIOCAPILLARIS. RESULTS: IOP WAS SIGNIFICANTLY REDUCED (POSTEXERCISE IOP = 13.02 MMHG +/- 2.82 MMHG) FROM THE INITIAL VALUE (PREEXERCISE IOP = 13.86 MMHG +/- 2.85 MMHG, P = 0.02). AMT SIGNIFICANTLY INCREASED (POSTEXERCISE AMT = 275.40 MUM +/- 10.85 MUM) FROM THE PREEXERCISE MEASUREMENT (PREEXERCISE AMT = 274.41 MUM +/- 10.89 MUM; P = 0.02). CONCLUSION: AFTER YOGA OCULAR EXERCISES, IOP SIGNIFICANTLY DECREASED AND AMT SIGNIFICANTLY INCREASED IN HEALTHY CONTROLS, SUGGESTING AN EFFECT OF THESE EXERCISES ON THE MACULAR THICKNESS. 2020 14 1819 14 PROTEIN YOGA: CONFORMATIONAL VERSATILITY OF THE HEMOLYSIN II C-TERMINAL DOMAIN DETAILED BY NMR STRUCTURES FOR MULTIPLE STATES. THE C-TERMINAL DOMAIN OF BACILLUS CEREUS HEMOLYSIN II (HLYIIC), STABILIZES THE TRANS-MEMBRANE-PORE FORMED BY THE HLYII TOXIN AND MAY AID IN TARGET CELL RECOGNITION. INITIAL EFFORTS TO DETERMINE THE NMR STRUCTURE OF HLYIIC WERE HAMPERED BY CIS/TRANS ISOMERIZATION ABOUT THE SINGLE PROLINE AT POSITION 405 THAT LEADS TO DOUBLING OF NMR RESONANCES. WE USED THE MUTANT P405M-HLYIIC THAT ELIMINATES THE CIS PROLINE TO DETERMINE THE NMR STRUCTURE OF THE DOMAIN, WHICH REVEALED A NOVEL FOLD. HERE, WE EXTEND EARLIER STUDIES TO THE NMR STRUCTURE DETERMINATION OF THE CIS AND TRANS STATES OF WT-HLYIIC THAT EXIST SIMULTANEOUSLY IN SOLUTION. THE PRIMARY STRUCTURAL DIFFERENCES BETWEEN THE CIS AND TRANS STATES ARE IN THE LOOP THAT CONTAINS P405, AND STRUCTURALLY ADJACENT LOOPS. THERMODYNAMIC LINKAGE ANALYSIS SHOWS THAT AT 25 C THE CIS PROLINE, WHICH ALREADY HAS A LARGE FRACTION OF 20% IN THE UNFOLDED PROTEIN, INCREASES TO 50% IN THE FOLDED STATE DUE TO COUPLING WITH THE GLOBAL STABILITY OF THE DOMAIN. THE P405M OR P405A SUBSTITUTIONS ELIMINATE HETEROGENEITY DUE TO PROLINE ISOMERIZATION BUT LEAD TO THE FORMATION OF A NEW DIMERIC SPECIES. THE NMR STRUCTURE OF THE DIMER SHOWS THAT IT IS FORMED THROUGH DOMAIN-SWAPPING OF STRAND BETA5, THE LAST SEGMENT OF SECONDARY STRUCTURE FOLLOWING P405. THE PRESENCE OF P405 IN WT-HLYIIC STRONGLY DISFAVORS THE DIMER COMPARED TO THE P405M-HLYIIC OR P405A-HLYIIC MUTANTS. THE WT PROLINE MAY THUS ACT AS A "GATEKEEPER," WARDING OFF AGGREGATIVE MISFOLDING. 2021 15 481 12 CLINICAL EFFICACY OF APAMARGA KSHARA YOGA IN THE MANAGEMENT OF SHVITRA (VITILIGO). INTRODUCTION: VITILIGO IS A PROGRESSIVE, IDIOPATHIC, PIGMENTATION DISORDER OF THE SKIN, CHARACTERIZED BY HYPOPIGMENTED PATCHES. THIS CONDITION IS COMPARED WITH SHVITRA IN AYURVEDA. MANY AYURVEDIC DRUGS ARE BENEFICIAL IN SUCH CASES AND APAMARGA KSHARA YOGA IS ONE AMONG THEM. AIM: TO EVALUATE THE EFFICACY OF APAMARGA KSHARA YOGA IN LEPA AND OINTMENT FORMS IN THE MANAGEMENT OF SHVITRA. MATERIALS AND METHODS: TOTAL 50 PATIENTS OF SHVITRA WERE RANDOMLY GROUPED INTO TWO. PATIENTS REGISTERED IN GROUP A (N = 25) WERE TREATED WITH APAMARGA KSHARA YOGA LEPA AND GROUP B (N = 25) WITH APAMARGA KSHARA YOGA OINTMENT FOR 2 MONTHS. RASAYANA CHURNA (3G) ALONG WITH HONEY AND GHEE WAS GIVEN TWICE DAILY INTERNALLY IN THE BOTH GROUPS. RESULTS: SIGNIFICANT IMPROVEMENT WAS FOUND IN THE SYMPTOMS OF SHVITRA WITH TREATMENT IN BOTH THE GROUPS. THE DIFFERENCE IN BETWEEN THE GROUPS WAS STATISTICALLY INSIGNIFICANT. CONCLUSION: BOTH FORMS OF APAMRAGA KSHARA YOGA ARE EFFECTIVE IN CASES OF SHVITRA AND CAN BE GOOD ALTERNATIVES FOR CONTEMPORARY MEDICINES. 2015 16 808 20 EFFECT OF YOGA ON ARTERIAL STIFFNESS IN ELDERLY SUBJECTS WITH INCREASED PULSE PRESSURE: A RANDOMIZED CONTROLLED STUDY. OBJECTIVE: WE AIMED TO DETERMINE THE EFFECT OF YOGA ON ARTERIAL FUNCTION IN ELDERLY WITH INCREASED PULSE PRESSURE (PP). DESIGN: RANDOMIZED CONTROLLED STUDY WITH TWO PARALLEL GROUPS. PARTICIPANTS: ELDERLY SUBJECTS WITH PP>/=60 MMHG (N=60). INTERVENTIONS: YOGA GROUP (N=30) WAS ASSIGNED FOR YOGA TRAINING AND BRISK-WALKING (BW) GROUP (N=30) FOR BRISK-WALK WITH STRETCHING EXERCISE FOR 1H IN THE MORNING FOR 6 DAYS IN A WEEK FOR 12 WEEKS. MAIN OUTCOME MEASURES: ARTERIAL STIFFNESS MEASURES: BRACHIAL-ANKLE PULSE WAVE VELOCITY (BAPWV), CAROTID-FEMORAL PULSE WAVE VELOCITY (C-F PWV), AORTIC AUGMENTATION INDEX (AIX@75), ARTERIAL STIFFNESS INDEX AT BRACHIAL (BASI) AND TIBIAL ARTERIES (AASI). TOTAL SERUM NITRIC OXIDE CONCENTRATION (NOX) AS AN INDEX OF ENDOTHELIAL FUNCTION. HEART RATE VARIABILITY (HRV) MEASURES: LOW FREQUENCY AND HIGH FREQUENCY IN NORMALIZED UNITS (LFNU, HFNU) AND LF/HF RATIO. RESULTS: THE MEAN BETWEEN-GROUP CHANGE (WITH 95% CI) IN ARTERIAL STIFFNESS: C-F PWV(M/S) [1.25(0.59-1.89); P<0.001], BAPWV(M/S) [1.96(0.76-3.16), P<0.01], AIX@75 [3.07(0.24-5.89), P=0.066], AASI [8.3(4.06-12.53), P<0.001]; ENDOTHELIAL FUNCTION INDEX: NO(MUMOL/L) [-9.03(-14.57 TO -3.47), P<0.001]; SBP(MMHG) [14.23(12.03-16.44), P<0.001], DBP(MMHG) [0.1(-1.95-2.15), P=0.38], PP(MMHG) [14.07(11.2-16.92), P<0.001], MAP(MMHG) [4.7(3.08-6.32), P<0.001]; AND CARDIAC AUTONOMIC FUNCTION: LF(NU) [4.81(1.54-8.08), P<0.01], HF(NU) [-4.13(-7.57 TO -0.69), P<0.01], LF/HF RATIO [0.84(0.3-1.37), P<0.001], INDICATE SIGNIFICANT DIFFERENCE IN EFFECTS OF TWO INTERVENTION ON ARTERIAL STIFFNESS, ENDOTHELIAL FUNCTION, BP AND CARDIAC AUTONOMIC ACTIVITY. THERE WAS SIGNIFICANT CHANGE WITHIN-YOGA GROUP IN VASCULAR FUNCTION, BP AND AUTONOMIC FUNCTION, WHILE NO SIGNIFICANT CHANGE WITHIN-BW GROUP WAS OBSERVED. CONCLUSION: OUR FINDINGS SUGGEST THAT YOGA PROGRAM OFFERED WAS MORE EFFECTIVE THAN BRISK-WALK IN REDUCING ARTERIAL STIFFNESS ALONG WITH BP IN ELDERLY INDIVIDUALS WITH INCREASED PP. YOGA CAN ALSO SIGNIFICANTLY REDUCE SYMPATHETIC ACTIVITY AND IMPROVE ENDOTHELIAL FUNCTION WITH ENHANCEMENT IN BIOAVAILABILITY OF NO. 2015 17 1360 27 IMMEDIATE EFFECTS OF YOGA BREATHING WITH INTERMITTENT BREATH HOLDING ON RESPONSE INHIBITION AMONG HEALTHY VOLUNTEERS. BACKGROUND: THERE IS VERY LITTLE EVIDENCE AVAILABLE ON THE EFFECTS OF YOGA-BASED BREATHING PRACTICES ON RESPONSE INHIBITION. THE CURRENT STUDY USED STOP-SIGNAL PARADIGM TO ASSESS THE EFFECTS OF YOGA BREATHING WITH INTERMITTENT BREATH HOLDING (YBH) ON RESPONSE INHIBITION AMONG HEALTHY VOLUNTEERS. MATERIALS AND METHODS: THIRTY-SIX HEALTHY VOLUNTEERS (17 MALES + 19 FEMALES), WITH MEAN AGE OF 20.31 +/- 3.48 YEARS FROM A UNIVERSITY, WERE RECRUITED IN A WITHIN-SUBJECT REPEATED MEASURES (RM) DESIGN. THE RECORDINGS FOR STOP SIGNAL TASK WERE PERFORMED ON THREE DIFFERENT DAYS FOR BASELINE, POST-YBH, AND POST YOGIC BREATH AWARENESS (YBA) SESSIONS. STOP-SIGNAL REACTION TIME (SSRT), MEAN REACTION TIME TO GO STIMULI (GO RT), AND THE PROBABILITY OF RESPONDING ON-STOP SIGNAL TRIALS (P [R/S]) WERE ANALYZED FOR 36 VOLUNTEERS USING RM ANALYSIS OF VARIANCE. RESULTS: SSRT REDUCED SIGNIFICANTLY IN BOTH YBH (218.33 +/- 38.38) AND YBA (213.15 +/- 37.29) GROUPS WHEN COMPARED TO BASELINE (231.98 +/- 29.54). NO SIGNIFICANT CHANGES WERE OBSERVED IN GO RT AND P (R/S). FURTHER, THE CHANGES IN SSRT WERE NOT SIGNIFICANTLY DIFFERENT AMONG YBH AND YBA GROUPS. CONCLUSION: BOTH YBH AND YBA GROUPS WERE FOUND TO ENHANCE RESPONSE INHIBITION IN THE STOP-SIGNAL PARADIGM. YBH COULD BE FURTHER EVALUATED IN CLINICAL SETTINGS FOR CONDITIONS WHERE RESPONSE INHIBITION IS ALTERED. 2018 18 1433 17 IMPROVING THE DEGREE OF PUBIC ARCH POST-YOGA EXERCISE DURING PREGNANCY. YOGA EXERCISES UNDERTAKEN DURING THE MATERNITY PERIOD MAY REDUCE UNPLEASANT SYMPTOMS DURING PREGNANCY AND REDUCE DELIVERY PAIN. FLEXIBILITY OF THE HIP JOINT IMPROVES THE DEGREE OF PUBIC ARCH CREATED IN AN OPEN-LEG POSTURE AND WIDENS THE PELVIC OUTLET REGION, SHORTENING THE TIME REQUIRED FOR DELIVERY AND FACILITATING EASY DELIVERY. THE DEGREE OF PUBIC ARCH IS RELATED TO THE FLEXIBILITY OF THE HIP JOINT. ALTHOUGH MANY STUDIES HAVE SHOWN THE EFFECT OF YOGA EXERCISE DURING PREGNANCY, THE EFFECT ON THE DEGREE OF THE PUBIC ARCH HAS NOT BEEN ELUCIDATED. TO ELUCIDATE WHETHER THE DEGREE OF THE PUBIC ARCH IS IMPROVED BY YOGA EXERCISE DURING PREGNANCY, THIS STUDY ENROLLED 177 PREGNANT SUBJECTS. THE DEGREE OF PUBIC ARCH PRE- AND POST-YOGA EXERCISE WAS MEASURED USING INSTRUMENTS IN AN OPEN-LEG POSTURE (SEATED WITH FEMURS ABDUCTED). THE MEAN PUBIC ARCH PRE- AND POST-YOGA WAS 122.61 AND 127.93 DEGREES, RESPECTIVELY. THE DEGREE OF PUBIC ARCH POST-YOGA SESSIONS WAS SIGNIFICANTLY INCREASED COMPARED WITH PRE-YOGA SESSIONS (P < 0.01). THIS STUDY SHOWED THAT YOGA EXERCISES DURING THE PREGNANCY PERIOD APPEAR TO IMPROVE THE DEGREE OF PUBIC ARCH. 2021 19 1764 19 POSTNATAL DEVELOPMENT AND REPRODUCTIVE PERFORMANCE OF F1 PROGENY EXPOSED IN UTERO TO AN AYURVEDIC CONTRACEPTIVE: PIPPALIYADI YOGA. PIPPALIYADI YOGA OR PIPPALIYADI VATI IS AN AYURVEDIC CONTRACEPTIVE USED IN INDIA SINCE ANCIENT TIMES. IT IS A COMBINATION OF POWDERED FRUIT BERRIES OF EMBELIA RIBES BURM.F. (MYRSINACEAE), PIPER LONGUM L. (PIPERACEAE) AND BORAX IN EQUAL PROPORTION. THOUGH THE CONTRACEPTIVE POTENTIAL IS KNOWN SINCE ANCIENT TIMES, NO SYSTEMATIC DEVELOPMENTAL TOXICITY STUDIES HAVE BEEN CARRIED OUT. THE PRESENT STUDY WAS CARRIED OUT TO EVALUATE THE POSTNATAL DEVELOPMENTAL TOXICITY AND THE REPRODUCTIVE PERFORMANCE OF THE PROGENY EXPOSED IN UTERO TO PIPPALIYADI. PIPPALIYADI YOGA WAS OBTAINED FROM NATIONAL INSTITUTE FOR PHARMACEUTICAL EDUCATION AND RESEARCH (NIPER), INDIA AND THE DEVELOPMENTAL TOXICITY WAS STUDIED BY ADMINISTERING THREE DOSES, VIZ. 140, 300 AND 700 MG/(KG DAY) TO GRAVID FEMALES FROM DAY 6 TO DAY 16 OF GESTATION. PIPPALIYADI DID NOT HAVE ANY ADVERSE DEVELOPMENTAL EFFECTS WITH LOW DOSES, HOWEVER, WITH THE FIVE TIMES HIGHER DOSE, A DECREASE IN BODY WEIGHT OF THE PUPS WAS OBSERVED. THE REPRODUCTIVE PERFORMANCE OF THE PROGENY BORN TO MOTHERS TREATED WITH PIPPALIYADI WAS NOT SIGNIFICANTLY AFFECTED. THE PRESENT STUDY SUGGESTS THAT IN UTERO EXPOSURE TO PIPPALIYADI DOES NOT HAVE ANY ADVERSE EFFECT ON THE POSTNATAL DEVELOPMENT AND REPRODUCTIVE PERFORMANCE OF THE F(1) PROGENY. 2007 20 1013 20 EFFECTS OF ONLINE YOGA AND TAI CHI ON PHYSICAL HEALTH OUTCOME MEASURES OF ADULT INFORMAL CAREGIVERS. AIMS: THIS STUDY AIMED TO INVESTIGATE THE EFFECTS OF ONLINE VINYASA YOGA (VY) AND TAIJIFIT (12 WEEKS) IN INFORMAL CAREGIVERS (>/=18 YEARS OF AGE). METHODS: TWENTY-NINE PARTICIPANTS WERE RANDOMIZED TO TWO GROUPS: VY (N = 16, 55.87 +/- 12.31 YEARS) OR TAIJIFIT (N = 13, 55.07 +/- 12.65 YEARS). MAIN OUTCOME MEASURES: PRIOR TO AND FOLLOWING THE STUDY, ASSESSMENTS WERE MADE FOR MUSCLE STRENGTH (1-RM LEG PRESS, CHEST PRESS, AND HANDGRIP), MUSCLE ENDURANCE (LEG PRESS AND CHEST PRESS; MAXIMAL NUMBER OF REPETITIONS PERFORMED TO FATIGUE AT 80% AND 70% BASELINE 1-RM, RESPECTIVELY), ABDOMINAL ENDURANCE (MAXIMUM NUMBER OF CONSECUTIVE CURL-UPS TO FATIGUE), TASKS OF FUNCTIONALITY (DYNAMIC BALANCE AND WALKING SPEED), AND FLEXIBILITY (SIT AND REACH). RESULTS: THERE WAS A SIGNIFICANT INCREASE OVER TIME FOR MUSCLE STRENGTH, MUSCLE ENDURANCE, TASKS OF FUNCTIONALITY, AND FLEXIBILITY (P = 0.001). THE VY GROUP EXPERIENCED A GREATER IMPROVEMENT IN CHEST PRESS ENDURANCE (VY: PRE 19.25 +/- 5.90, POST 28.06 +/- 7.60 REPS; TAIJIFIT PRE 15.69 +/- 4.49, POST 21.07 +/- 5.85 REPS; P = 0.019) AND ABDOMINAL ENDURANCE (VY: PRE 37.12 +/- 31.26, POST 68.43 +/- 55.07 REPS; TAIJIFIT PRE 19.23 +/- 19.00, POST 32.07 +/- 20.87 REPS; P = 0.034) COMPARED TO THE TAIJIFIT GROUP. CONCLUSIONS: VY AND TAIJIFIT ARE EFFECTIVE FOR IMPROVING MUSCLE STRENGTH AND ENDURANCE, TASKS OF FUNCTIONALITY, AND FLEXIBILITY IN INFORMAL CAREGIVERS. VY LED TO GREATER GAINS IN CHEST PRESS ENDURANCE AND ABDOMINAL CURL-UPS. 2019