1 360 137 ASSOCIATION OF YOGA PRACTICE AND SERUM CORTISOL LEVELS IN CHRONIC PERIODONTITIS PATIENTS WITH STRESS-RELATED ANXIETY AND DEPRESSION. AIM: REDUCING THE PSYCHOSOCIAL STRESS BY VARIOUS METHODS CAN IMPROVE OVERALL HEALTH, AND YOGA IS NOW CONSIDERED AS AN EASILY AVAILABLE ALTERNATIVE METHOD. THE PRESENT CROSS-SECTIONAL PILOT STUDY WAS CONDUCTED MAINLY TO FIND THE ASSOCIATION OF YOGA PRACTICE WITH PERIODONTAL DISEASE BY MEASURING SERUM CORTISOL LEVELS. MATERIALS AND METHODS: A TOTAL OF 70 SUBJECTS WITH AGE RANGE OF 35-60 YEARS SUFFERING WITH CHRONIC PERIODONTITIS WERE DIVIDED INTO GROUP I (WITH STRESS), GROUP II (WITHOUT STRESS), AND GROUP III (PRACTICING YOGA). PSYCHOLOGICAL EVALUATION WAS CARRIED OUT USING HAMILTON ANXIETY RATING SCALE (HAM-A) AND ZUNG SELF-RATING DEPRESSION SCALE (ZSDS). PERIODONTAL PARAMETERS LIKE PLAQUE INDEX (PI), PROBING POCKET DEPTH (PPD), AND CLINICAL ATTACHMENT LEVEL (CAL) AT 5-8 MM AND >8 MM WERE RECORDED. BLOOD SAMPLES WERE COLLECTED AND SERUM CORTISOL LEVELS WERE MEASURED. RESULTS: MEAN AGE, PLAQUE SCORES, AND NUMBER OF TEETH WITH PPD AND CAL AT 5-8 MM AND >8 MM WERE SIMILAR IN ALL THE GROUPS, EXCEPT BETWEEN GROUP I AND GROUP III WHERE A MULTIPLE COMPARISON WITH TUKEY'S POST-HOC TEST SHOWED SIGNIFICANT DIFFERENCE IN PLAQUE INDEX (P < 0.038) AND THE NUMBER OF TEETH WITH CAL 5-8 MM (P < 0.016). SERUM CORTISOL LEVELS AND HAM-A SCALE AND ZSDS SCORES SHOWED HIGHLY SIGNIFICANT VALUE (P < 0.001) IN GROUP I SUBJECTS WHEN COMPARED WITH GROUP II AND GROUP III SUBJECTS. CONCLUSION: CROSS-SECTIONAL OBSERVATION DONE AMONG THREE GROUPS SHOWED THAT INDIVIDUALS PRACTICING YOGA REGULARLY HAD LOW SERUM CORTISOL LEVELS, HAM-A SCALE AND ZSDS SCORES, AND BETTER PERIODONTAL HEALTH. 2016 2 1130 29 EFFICACY OF YOGA FOR DEPRESSED POSTPARTUM WOMEN: A RANDOMIZED CONTROLLED TRIAL. BACKGROUND: UP TO 20% OF WOMEN EXPERIENCE POSTPARTUM DEPRESSION (PPD). PPD IS ASSOCIATED WITH ANXIETY AND POOR HEALTH-RELATED QUALITY OF LIFE (HRQOL). EFFICACIOUS TREATMENTS ARE CRITICAL; MANY WOMEN WITH PPD PREFER COMPLEMENTARY THERAPIES. THUS, THE CURRENT STUDY EXAMINED YOGA AS A COMPLEMENTARY THERAPY FOR PPD. METHODS: FIFTY-SEVEN POSTPARTUM WOMEN WITH SCORES >/=12 ON THE HAMILTON DEPRESSION RATING SCALE WERE RANDOMLY ASSIGNED TO A YOGA (N = 28) OR WAIT-LIST CONTROL (N = 29) GROUP. THE YOGA INTERVENTION CONSISTED OF 16 CLASSES OVER 8 WEEKS. OUTCOMES WERE DEPRESSION, ANXIETY, AND HRQOL. RESULTS: THE YOGA GROUP EXPERIENCED SIGNIFICANTLY GREATER RATE OF IMPROVEMENT IN DEPRESSION, ANXIETY, AND HRQOL, RELATIVE TO THE CONTROL GROUP WITH MODERATE TO LARGE EFFECTS. RELIABLE CHANGE INDEX ANALYSES REVEALED THAT 78% OF WOMEN IN THE YOGA GROUP EXPERIENCED CLINICALLY SIGNIFICANT CHANGE. CONCLUSION: THESE FINDINGS SUPPORT YOGA AS A PROMISING COMPLEMENTARY THERAPY FOR PPD, AND WARRANT LARGE-SCALE REPLICATION STUDIES. TRIAL REGISTRATION: HTTP://CLINICALTRIALS.GOV/NCT02213601. 2015 3 240 35 A WEB-BASED COGNITIVE BEHAVIORAL THERAPY, MINDFULNESS MEDITATION, AND YOGA INTERVENTION FOR POSTTRAUMATIC STRESS DISORDER: SINGLE-ARM EXPERIMENTAL CLINICAL TRIAL. BACKGROUND: POSTTRAUMATIC STRESS DISORDER (PTSD) IS A DEBILITATING, UNDERTREATED CONDITION. THE WEB-BASED DELIVERY OF COGNITIVE BEHAVIORAL THERAPY SUPPLEMENTED WITH MINDFULNESS MEDITATION AND YOGA IS A VIABLE TREATMENT THAT EMPHASIZES SELF-DIRECTED DAILY PRACTICE. OBJECTIVE: THIS STUDY AIMS TO EXAMINE THE EFFECTIVENESS OF A WEB-BASED COGNITIVE BEHAVIORAL THERAPY, MINDFULNESS, AND YOGA (CBT-MY) PROGRAM DESIGNED FOR DAILY USE. METHODS: WE CONDUCTED AN 8-WEEK, SINGLE-ARM, EXPERIMENTAL, REGISTERED CLINICAL TRIAL ON ADULTS REPORTING PTSD SYMPTOMS (N=22; AGED 18-35 YEARS). EACH PARTICIPANT RECEIVED WEB-BASED CBT-MY CONTENT AND AN HOUR OF WEB-BASED COUNSELING EACH WEEK. PRE-POST OUTCOMES INCLUDED SELF-REPORTED PTSD SYMPTOM SEVERITY, DEPRESSION, ANXIETY, CHRONIC PAIN, AND MINDFULNESS. PRE-POST PSYCHOPHYSIOLOGICAL OUTCOMES INCLUDED PEAK PUPIL DILATION (PPD) AND HEART RATE VARIABILITY (HRV). HRV AND PPD WERE ALSO COMPARED WITH CROSS-SECTIONAL DATA FROM A NON-PTSD COMPARISON GROUP WITHOUT A HISTORY OF CLINICAL MENTAL HEALTH DIAGNOSES AND CBT-MY EXPOSURE (N=46). RESULTS: PRE-POST INTENTION-TO-TREAT ANALYSES REVEALED SUBSTANTIAL IMPROVEMENTS IN PTSD SEVERITY (D=1.60), DEPRESSION (D=0.83), ANXIETY (D=0.99), AND MINDFULNESS (D=0.88). LINEAR MULTILEVEL MIXED MODELS DEMONSTRATED A SIGNIFICANT PRE-POST REDUCTION IN PPD (B=-0.06; SE=0.01; P<.001; D=0.90) BUT NO SIGNIFICANT PRE-POST CHANGE IN HRV (P=.87). OVERALL, PARTICIPANTS SPENT AN AVERAGE OF 11.53 (SD 22.76) MIN/DAY ON SELF-DIRECTED MINDFULNESS PRACTICE. CONCLUSIONS: WEB-BASED CBT-MY WAS ASSOCIATED WITH CLINICALLY SIGNIFICANT SYMPTOM REDUCTIONS AND SIGNIFICANT PPD CHANGES, SUGGESTING HEALTHIER AUTONOMIC FUNCTIONING. FUTURE RANDOMIZED CONTROLLED TRIALS ARE NEEDED TO FURTHER EXAMINE THE GAINS APPARENT IN THIS SINGLE-ARM STUDY. TRIAL REGISTRATION: CLINICALTRIALS.GOV NCT03684473; HTTPS://CLINICALTRIALS.GOV/CT2/SHOW/NCT03684473. 2022 4 1409 55 IMPACT OF YOGA ON PERIODONTAL DISEASE AND STRESS MANAGEMENT. BACKGROUND: YOGA IS CONSIDERED TO BE ONE OF THE MOST IMPORTANT, EFFECTIVE, AND VALUABLE TOOLS AVAILABLE FOR MAN TO OVERCOME VARIOUS PHYSICAL AND PSYCHOLOGICAL PROBLEMS. STRESS CONTRIBUTES SIGNIFICANTLY TO THE PATHOGENESIS OF PERIODONTAL DISEASES; HENCE, IT BECOMES IMPORTANT TO REDUCE THE LEVEL OF STRESS FOR PREVENTION AND MANAGEMENT OF DISEASES. AIMS AND OBJECTIVES: THE PRESENT STUDY WAS AIMED: (1) TO UNDERSTAND AND ANALYZE THE POSSIBILITIES OF EMPLOYING YOGIC PRACTICES IN THE TREATMENT OF PERIODONTAL DISEASE ALONG WITH CONVENTIONAL DENTAL THERAPY, (2) TO UNDERSTAND THE EFFECT OF STRESS ON PERIODONTAL TREATMENT OUTCOME, (3) TO EVALUATE THE EFFICACY OF YOGA IN THE MANAGEMENT OF PERIODONTAL DISEASE WITH REFERENCE TO STRESS. MATERIALS AND METHODS: AN OUTPATIENT DEPARTMENT-BASED PARALLEL GROUP RANDOMIZED STUDY WAS PERFORMED WITH STANDARD TREATMENT FOR PERIODONTAL DISEASE YOGA THERAPY AS GROUP II AND ONLY STANDARD TREATMENT AS GROUP I. PERIODONTAL HEALTH STATUS WAS RECORDED USING INDICES OF MODIFIED PLAQUE INDEX (PI), BLEEDING ON PROBING (BOP), PROBING DEPTH, AND CLINICAL ATTACHMENT LOSS (CAL). THE COHEN'S PERCEIVED STRESS QUESTIONNAIRE WAS ALSO USED TO DETERMINE STRESS SEVERITY. THE YOGIC INTERVENTION CONSISTS OF LECTURES AND PRACTICAL SESSIONS ON ASANAS, PRANAYAMA, KRIYAS, AND MEDITATION. RESULTS: REPEATED MEASURE ANALYSIS OF VARIANCE REVEALED A SIGNIFICANT DIFFERENCE (P < 0.001) IN ALL THE OUTCOME VARIABLES WITH RESPECT TO TIME IN BOTH GROUPS. IT WAS OBSERVED THAT MEAN PI SCORE REDUCED BY 1.35 IN GROUP II AS COMPARED TO 0.54 IN GROUP I, MEAN PROBING POCKET DEPTH REDUCED BY 1.60 IN GROUP II AS COMPARED TO ONLY 0.68 IN GROUP I, AND MEAN CAL SCORE REDUCED BY 1.60 IN GROUP II AS COMPARED TO 0.68 IN GROUP I. SIMILARLY, COHEN'S PERCEIVED STRESS SCALE SCORE ALSO REDUCED BY 18.76 POINTS IN GROUP II AS COMPARED TO ONLY 2.58 POINTS IN GROUP I, BOP ALSO SHOWS BETTER IMPROVEMENT IN GROUP II WITH A REDUCTION OF 0.68 AS COMPARED TO REDUCTION OF ONLY 0.08 IN GROUP I. THE RESULTS OBTAINED ASCERTAINED THE ROLE OF YOGA IN STRESS REDUCTION IN PERIODONTAL DISEASE. CONCLUSION: ALTHOUGH YOGA DOES NOT PLAY A DIRECT ROLE IN IMPROVING PERIODONTAL DISEASE, IT ACCELERATES THE TREATMENT OUTCOMES BY COMBATING THE STRESS WHICH IS A MAJOR FACTOR AFFECTING THE TREATMENT OF PERIODONTAL DISEASE. 2017 5 2549 35 YOGA FOR CANCER SURVIVORS WITH CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY: HEALTH-RELATED QUALITY OF LIFE OUTCOMES. BACKGROUND: YOGA IS A MEDITATIVE MOVEMENT THERAPY FOCUSED ON MIND-BODY AWARENESS. THE IMPACT OF YOGA ON HEALTH-RELATED QUALITY OF LIFE (HRQOL) OUTCOMES IN PATIENTS WITH CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY (CIPN) IS UNCLEAR. METHODS: WE CONDUCTED A PILOT RANDOMIZED WAIT-LIST CONTROLLED TRIAL OF 8 WEEKS OF YOGA (N = 21) VERSUS WAIT-LIST CONTROL (N = 20) FOR CIPN IN 41 BREAST AND GYNECOLOGICAL CANCER SURVIVORS WITH PERSISTENT MODERATE TO SEVERE CIPN. HRQOL ENDPOINTS WERE HOSPITAL ANXIETY AND DEPRESSION SCALE (HADS), BRIEF FATIGUE INVENTORY (BFI), AND INSOMNIA SEVERITY INDEX (ISI). THE TREATMENT EXPECTANCY SCALE (TES) WAS ADMINISTERED AT BASELINE. WE ESTIMATED MEAN CHANGES AND 95% CONFIDENCE INTERVALS (CIS) FROM BASELINE TO WEEKS 8 AND 12 AND COMPARED ARMS USING CONSTRAINED LINEAR MIXED MODELS. RESULTS: AT WEEK 8, HADS ANXIETY SCORES DECREASED -1.61 (-2.75, -0.46) IN THE YOGA ARM AND -0.32 (-1.38, 0.75) POINTS IN THE WAIT-LIST CONTROL ARM (P = 0.099). AT WEEK 12, HADS ANXIETY SCORES DECREASED -1.42 (-2.57, -0.28) IN YOGA COMPARED TO AN INCREASE OF 0.46 (-0.60, 1.53) IN WAIT-LIST CONTROL (P = 0.017). THERE WERE NO SIGNIFICANT DIFFERENCES IN HADS DEPRESSION, BFI, OR ISI SCORES BETWEEN YOGA AND WAIT-LIST CONTROL. BASELINE TES WAS SIGNIFICANTLY HIGHER IN YOGA THAN IN WAIT-LIST CONTROL (14.9 VS. 12.7, P = 0.019). TES WAS NOT ASSOCIATED WITH HADS ANXIETY REDUCTION AND HADS ANXIETY REDUCTION WAS NOT ASSOCIATED WITH CIPN PAIN REDUCTION. CONCLUSIONS: YOGA MAY REDUCE ANXIETY IN PATIENTS WITH CIPN. FUTURE STUDIES ARE NEEDED TO CONFIRM THESE FINDINGS. CLINICAL TRIAL REGISTRATION NUMBER: CLINICALTRIALS.GOV IDENTIFIER: NCT03292328. 2021 6 2318 36 TREATING MAJOR DEPRESSION WITH YOGA: A PROSPECTIVE, RANDOMIZED, CONTROLLED PILOT TRIAL. BACKGROUND: CONVENTIONAL PHARMACOTHERAPIES AND PSYCHOTHERAPIES FOR MAJOR DEPRESSION ARE ASSOCIATED WITH LIMITED ADHERENCE TO CARE AND RELATIVELY LOW REMISSION RATES. YOGA MAY OFFER AN ALTERNATIVE TREATMENT OPTION, BUT RIGOROUS STUDIES ARE FEW. THIS RANDOMIZED CONTROLLED TRIAL WITH BLINDED OUTCOME ASSESSORS EXAMINED AN 8-WEEK HATHA YOGA INTERVENTION AS MONO-THERAPY FOR MILD-TO-MODERATE MAJOR DEPRESSION. METHODS: INVESTIGATORS RECRUITED 38 ADULTS IN SAN FRANCISCO MEETING CRITERIA FOR MAJOR DEPRESSION OF MILD-TO-MODERATE SEVERITY, PER STRUCTURED PSYCHIATRIC INTERVIEW AND SCORES OF 14-28 ON BECK DEPRESSION INVENTORY-II (BDI). AT SCREENING, INDIVIDUALS ENGAGED IN PSYCHOTHERAPY, ANTIDEPRESSANT PHARMACOTHERAPY, HERBAL OR NUTRACEUTICAL MOOD THERAPIES, OR MIND-BODY PRACTICES WERE EXCLUDED. PARTICIPANTS WERE 68% FEMALE, WITH MEAN AGE 43.4 YEARS (SD = 14.8, RANGE = 22-72), AND MEAN BDI SCORE 22.4 (SD = 4.5). TWENTY PARTICIPANTS WERE RANDOMIZED TO 90-MINUTE HATHA YOGA PRACTICE GROUPS TWICE WEEKLY FOR 8 WEEKS. EIGHTEEN PARTICIPANTS WERE RANDOMIZED TO 90-MINUTE ATTENTION CONTROL EDUCATION GROUPS TWICE WEEKLY FOR 8 WEEKS. CERTIFIED YOGA INSTRUCTORS DELIVERED BOTH INTERVENTIONS AT A UNIVERSITY CLINIC. PRIMARY OUTCOME WAS DEPRESSION SEVERITY, MEASURED BY BDI SCORES EVERY 2 WEEKS FROM BASELINE TO 8 WEEKS. SECONDARY OUTCOMES WERE SELF-EFFICACY AND SELF-ESTEEM, MEASURED BY SCORES ON THE GENERAL SELF-EFFICACY SCALE (GSES) AND ROSENBERG SELF-ESTEEM SCALE (RSES) AT BASELINE AND AT 8 WEEKS. RESULTS: IN INTENT-TO-TREAT ANALYSIS, YOGA PARTICIPANTS EXHIBITED SIGNIFICANTLY GREATER 8-WEEK DECLINE IN BDI SCORES THAN CONTROLS (P-VALUE = 0.034). IN SUB-ANALYSES OF PARTICIPANTS COMPLETING FINAL 8-WEEK MEASURES, YOGA PARTICIPANTS WERE MORE LIKELY TO ACHIEVE REMISSION, DEFINED PER FINAL BDI SCORE 3 EPISODES IN THE PAST 1 YEAR) AND POSITIVE HEAD-UP TILT TEST TO GUIDELINE-DIRECTED THERAPY (GROUP 1) OR YOGA THERAPY (GROUP 2). PATIENTS IN GROUP 1 WERE ADVISED GUIDELINE-DIRECTED TREATMENT AND GROUP 2 WAS TAUGHT YOGA BY A CERTIFIED INSTRUCTOR. THE PRIMARY ENDPOINT WAS VVS RECURRENCES AND QOL. BETWEEN JUNE 2015 AND FEBRUARY 2017, 97 HIGHLY SYMPTOMATIC VVS PATIENTS WERE RANDOMIZED (GROUP 1: 47 AND GROUP 2: 50). THE MEAN AGE WAS 33.1 +/- 16.6 YEARS, MALE:FEMALE OF 40:57, SYMPTOM DURATION OF 17.1 +/- 20.7 MONTHS, WITH A MEAN OF 6.4 +/- 6.1 SYNCOPE EPISODES. OVER A FOLLOW-UP OF 14.3 +/- 2.1 MONTHS GROUP 2 HAD SIGNIFICANTLY LOWER SYNCOPE BURDEN COMPARED WITH GROUP 1 AT 3 (0.8 +/- 0.9 VS. 1.8 +/- 1.4, P < 0.001), 6 (1.0 +/- 1.2 VS. 3.4 +/- 3.0, P < 0.001), AND AT 12 MONTHS (1.1 +/- 0.8 VS. 3.8 +/- 3.2, P < 0.001). THE SYNCOPE FUNCTIONAL SCORE QUESTIONNAIRE WAS SIGNIFICANTLY LOWER IN GROUP 2 COMPARED WITH GROUP 1 AT 3 (31.4 +/- 7.2 VS. 64.1 +/- 11.5, P < 0.001), 6 (26.4 +/- 6.3 VS. 61.4 +/- 10.7, P < 0.001), AND 12 MONTHS (22.2 +/- 4.7 VS. 68.3 +/- 11.4, P < 0.001). CONCLUSION: FOR PATIENTS WITH RECURRENT VVS, GUIDED YOGA THERAPY IS SUPERIOR TO CONVENTIONAL THERAPY IN REDUCING SYMPTOM BURDEN AND IMPROVING QOL. 2021 8 945 34 EFFECTS OF A 12-WEEK YOGA VERSUS A 12-WEEK EDUCATIONAL FILM INTERVENTION ON SYMPTOMS OF RESTLESS LEGS SYNDROME AND RELATED OUTCOMES: AN EXPLORATORY RANDOMIZED CONTROLLED TRIAL. STUDY OBJECTIVES: TO ASSESS THE EFFECTS OF A YOGA VERSUS EDUCATIONAL FILM (EF) PROGRAM ON RESTLESS LEGS SYNDROME (RLS) SYMPTOMS AND RELATED OUTCOMES IN ADULTS WITH RLS. METHODS: FORTY-ONE COMMUNITY-DWELLING, AMBULATORY NONPREGNANT ADULTS WITH MODERATE TO SEVERE RLS WERE RANDOMIZED TO A 12-WEEK YOGA (N = 19) OR EF PROGRAM (N = 22). IN ADDITION TO ATTENDING CLASSES, ALL PARTICIPANTS COMPLETED PRACTICE/TREATMENT LOGS. YOGA GROUP PARTICIPANTS WERE ASKED TO PRACTICE AT HOME 30 MINUTES PER DAY ON NONCLASS DAYS; EF PARTICIPANTS WERE INSTRUCTED TO RECORD ANY RLS TREATMENTS USED ON THEIR DAILY LOGS. CORE OUTCOMES ASSESSED PRETREATMENT AND POSTTREATMENT WERE RLS SYMPTOMS AND SYMPTOM SEVERITY (INTERNATIONAL RLS STUDY GROUP SCALE (IRLS) AND RLS ORDINAL SCALE), SLEEP QUALITY, MOOD, PERCEIVED STRESS, AND QUALITY OF LIFE (QOL). RESULTS: THIRTY ADULTS (13 YOGA, 17 EF), AGED 24 TO 73 (MEAN = 50.4 +/- 2.4 YEARS), COMPLETED THE 12-WEEK STUDY (78% FEMALE, 80.5% WHITE). POST-INTERVENTION, BOTH GROUPS SHOWED SIGNIFICANT IMPROVEMENT IN RLS SYMPTOMS AND SEVERITY, PERCEIVED STRESS, MOOD, AND QOL-MENTAL HEALTH (P