1 439 152 CARDIOVASCULAR, CELLULAR, AND NEURAL ADAPTATIONS TO HOT YOGA VERSUS NORMAL-TEMPERATURE YOGA. CONTEXT: CHRONIC HEAT EXPOSURE PROMOTES CARDIOVASCULAR AND CELLULAR ADAPTATIONS, IMPROVING AN ORGANISM'S ABILITY TO TOLERATE SUBSEQUENT STRESSORS. HEAT EXPOSURE MAY ALSO PROMOTE NEURAL ADAPTATIONS AND ALTER THE NEURAL-HORMONAL STRESS RESPONSE. HOT-TEMPERATURE YOGA (HY) COMBINES MIND-BODY EXERCISE WITH HEAT EXPOSURE. THE ADDED HEAT COMPONENT IN HY MAY INDUCE CARDIOVASCULAR AND CELLULAR CHANGES, ALONG WITH NEURAL BENEFITS AND MODULATION OF STRESS HORMONES. AIMS: THE PURPOSE OF THE PRESENT STUDY IS TO COMPARE THE CARDIOVASCULAR, CELLULAR HEAT SHOCK PROTEIN 70 (HSP70), NEURAL, AND HORMONAL ADAPTATIONS OF HY VERSUS NORMAL-TEMPERATURE YOGA (NY). SETTINGS AND DESIGN: TWENTY-TWO SUBJECTS (MALES = 11 AND FEMALES = 11, 26 +/- 6 YEARS) COMPLETED 4 WEEKS OF NY (N = 11) OR HY (N = 11, 41 DEGREES C, 40% HUMIDITY). YOGA SESSIONS WERE PERFORMED 3 TIMES/WEEK FOLLOWING A MODIFIED BIKRAM PROTOCOL. SUBJECTS AND METHODS: PRE- AND POSTTESTING INCLUDED (1) HEMODYNAMIC MEASURES DURING A HEAT TOLERANCE TEST AND MAXIMAL AEROBIC FITNESS TEST; (2) NEURAL AND HORMONAL ADAPTATIONS USING SERUM BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) AND ADRENOCORTICOTROPIC HORMONE (ACTH), ALONG WITH A MENTAL STRESS QUESTIONNAIRE; AND (3) CELLULAR ADAPTATIONS (HSP70) IN PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMCS). STATISTICAL ANALYSIS: WITHIN- AND BETWEEN-GROUP STUDENT'S T-TEST ANALYSES WERE CONDUCTED TO COMPARE PRE- AND POST-VO2 MAX, PERCEIVED STRESS, BDNF, HSP70, AND ACTH IN HY AND NY GROUPS. RESULTS: MAXIMAL AEROBIC FITNESS INCREASED IN THE HY GROUP ONLY. NO EVIDENCE OF HEAT ACCLIMATION OR CHANGE IN MENTAL STRESS WAS OBSERVED. SERUM BDNF SIGNIFICANTLY INCREASED IN YOGA GROUPS COMBINED. ANALYSIS OF HSP70 SUGGESTED HIGHER EXPRESSION OF HSP70 IN THE HY GROUP ONLY. CONCLUSIONS: TWELVE SESSIONS OF HY PROMOTED CARDIOVASCULAR FITNESS AND CELLULAR THERMOTOLERANCE ADAPTATIONS. SERUM BDNF INCREASED IN RESPONSE TO YOGA (NY + HY) AND APPEARED TO NOT BE TEMPERATURE DEPENDENT. 2021
2 942 27 EFFECTS OF 8-WEEK HATHA YOGA TRAINING ON METABOLIC AND INFLAMMATORY MARKERS IN HEALTHY, FEMALE CHINESE SUBJECTS: A RANDOMIZED CLINICAL TRIAL. WE AIMED TO DETERMINE THE EFFECTS OF AN 8 WK HATHA YOGA TRAINING ON BLOOD GLUCOSE, INSULIN, LIPID PROFILES, ENDOTHELIAL MICROPARTICLES (EMPS), AND INFLAMMATORY STATUS IN HEALTHY, LEAN, AND FEMALE CHINESE SUBJECTS. A TOTAL OF 30 HEALTHY, FEMALE CHINESE SUBJECTS WERE RECRUITED AND RANDOMIZED INTO CONTROL OR YOGA PRACTICE GROUP. THE YOGA PRACTICE INCLUDED 8 WKS OF YOGA PRACTICE (2 TIMES/WK) FOR A TOTAL OF 16 TIMES. FASTING BLOOD SAMPLES WERE COLLECTED BEFORE AND AFTER YOGA TRAINING. PLASMA WAS ISOLATED FOR THE MEASUREMENT OF LIPID PROFILES, GLUCOSE, INSULIN, EMPS, AND INFLAMMATORY CYTOKINES. WHOLE BLOOD WAS CULTURED EX VIVO AND STIMULATED WITH LIPOPOLYSACCHARIDE (LPS) AND PAM3CYS-SK4. PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMCS) WERE ISOLATED FOR THE MEASUREMENT OF TLR2 AND TLR4 PROTEIN EXPRESSION. YOGA PRACTICE SIGNIFICANTLY REDUCED PLASMA CHOLESTEROL, LDL-CHOLESTEROL, INSULIN LEVELS, AND CD31+/CD42B- EMPS. CULTURED WHOLE BLOOD FROM THE YOGA GROUP HAS REDUCED PROINFLAMMATORY CYTOKINES SECRETION BOTH AT UNSTIMULATED CONDITION AND WHEN STIMULATED WITH PAM3CYS-SK4; THIS MIGHT BE ASSOCIATED WITH REDUCED TLR2 PROTEIN EXPRESSION IN PBMCS AFTER YOGA TRAINING. HATHA YOGA PRACTICE IN HEALTHY CHINESE FEMALE SUBJECTS COULD IMPROVE HALLMARKS RELATED TO METS; THUS IT CAN BE CONSIDERED AS AN ANCILLARY INTERVENTION IN THE PRIMARY METS PREVENTION FOR THE HEALTHY POPULATION. THIS TRIAL IS REGISTERED WITH CHICTR-IOR-14005747. 2016
3 1873 25 RAPID GENE EXPRESSION CHANGES IN PERIPHERAL BLOOD LYMPHOCYTES UPON PRACTICE OF A COMPREHENSIVE YOGA PROGRAM. ONE OF THE MOST COMMON INTEGRATIVE MEDICINE (IM) MODALITIES IS YOGA AND RELATED PRACTICES. PREVIOUS WORK HAS SHOWN THAT YOGA MAY IMPROVE WELLNESS IN HEALTHY PEOPLE AND HAVE BENEFITS FOR PATIENTS. HOWEVER, THE MECHANISMS OF HOW YOGA MAY POSITIVELY AFFECT THE MIND-BODY SYSTEM ARE LARGELY UNKNOWN. HERE WE HAVE ASSESSED POSSIBLE RAPID CHANGES IN GLOBAL GENE EXPRESSION PROFILES IN THE PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMCS) IN HEALTHY PEOPLE THAT PRACTICED EITHER A COMPREHENSIVE YOGA PROGRAM OR A CONTROL REGIMEN. THE EXPERIMENTAL SESSIONS INCLUDED GENTLE YOGA POSTURES, BREATHING EXERCISES, AND MEDITATION (SUDARSHAN KRIYA AND RELATED PRACTICES--SK&P) COMPARED WITH A CONTROL REGIMEN OF A NATURE WALK AND LISTENING TO RELAXING MUSIC. WE SHOW THAT THE SK&P PROGRAM HAS A RAPID AND SIGNIFICANTLY GREATER EFFECT ON GENE EXPRESSION IN PBMCS COMPARED WITH THE CONTROL REGIMEN. THESE DATA SUGGEST THAT YOGA AND RELATED PRACTICES RESULT IN RAPID GENE EXPRESSION ALTERATIONS WHICH MAY BE THE BASIS FOR THEIR LONGER TERM CELL BIOLOGICAL AND HIGHER LEVEL HEALTH EFFECTS. 2013
4 2120 26 THE EFFECT OF YOGA TRAINING ON ENHANCEMENT OF ADRENOCORTICOTROPIC HORMONE (ACTH) AND CORTISOL LEVELS IN FEMALE PATIENTS WITH MULTIPLE SCLEROSIS. THE EFFECT OF 8 WEEKS YOGA TRAINING ON CORTISOL AND ADRENOCORTICOTROPIC HORMONE (ACTH) LEVELS IN FEMALE PATIENTS WITH MULTIPLE SCLEROSIS (MS) IS EXAMINED. TWENTY FOUR MS FEMALE PATIENTS WITH EXPANDED DISABILITY STATUS SCALE (EDSS) 1 TO 5.5 PARTICIPATED IN THIS STUDY AS THE SUBJECT. THE PARTICIPANTS WERE DIVIDED INTO CONTROL (N = 10) OR TRAINING GROUP (N = 14) RANDOMLY. TRAINING GROUP PERFORMED 90 MIN YOGA TRAINING PER SESSION, 3 DAYS A WEEK FOR 8 WEEKS. ASSESSMENTS INCLUDE BODY COMPOSITION MEASUREMENT AND BLOOD SAMPLING 48 H BEFORE FIRST SESSION AND 48 H AFTER THE INTERVENTION. THE RESULTS DEMONSTRATED THAT ACTH INCREASED AND CORTISOL DECREASED COMPARED TO THE CONTROL GROUP (P < 0.05); IN CONCLUSION, IT SEEMS THAT YOGA TRAINING MODULATES ACTH LEVEL IN CONCOMITANT WITH REDUCTION IN CORTISOL LEVEL IN FEMALE PATIENTS WITH MS. 2017
5 449 18 CHANGES IN CARDIOVASCULAR RISK FACTORS AND HORMONES DURING A COMPREHENSIVE RESIDENTIAL THREE MONTH KRIYA YOGA TRAINING AND VEGETARIAN NUTRITION. IN PARTICIPANTS OF A COMPREHENSIVE RESIDENTIAL THREE MONTH YOGA AND MEDIATION TRAINING PROGRAMME LIVING ON A LOW FAT LACTO-VEGETARIAN DIET CHANGES IN CARDIOVASCULAR RISK FACTORS AND HORMONES WERE STUDIED. SUBSTANTIAL RISK FACTOR REDUCTION WAS FOUND. BODY MASS INDEX, TOTAL SERUM AND LDL CHOLESTEROL, FIBRINOGEN, AND BLOOD PRESSURE WERE SIGNIFICANTLY REDUCED ESPECIALLY IN THOSE WITH ELEVATED LEVELS. URINARY EXCRETION OF ADRENALINE, NORADRENALINE, DOPAMINE, ALDOSTERONE, AS WELL AS SERUM TESTOSTERONE AND LUTEINIZING HORMONE LEVELS WERE REDUCED, WHILE CORTISOL EXCRETION INCREASED SIGNIFICANTLY. 1997
6 1045 36 EFFECTS OF YOGA INTERVENTIONS PRACTISED IN HEATED AND THERMONEUTRAL CONDITIONS ON ENDOTHELIUM-DEPENDENT VASODILATATION: THE BIKRAM YOGA HEART STUDY. NEW FINDINGS: WHAT IS THE CENTRAL QUESTION OF THIS STUDY? DOES THE HEATED PRACTICE ENVIRONMENT ENHANCE THE EFFECTS OF BIKRAM YOGA ON ENDOTHELIUM-DEPENDENT VASODILATATION IN HEALTHY, MIDDLE-AGED ADULTS? WHAT IS THE MAIN FINDING AND ITS IMPORTANCE? THE PRIMARY FINDING FROM THIS INVESTIGATION IS THAT THE HATHA YOGA POSTURES IN THE BIKRAM YOGA SERIES PRODUCE SIMILAR ENHANCEMENTS IN ENDOTHELIUM-DEPENDENT VASODILATATION IN HEALTHY, MIDDLE-AGED ADULTS REGARDLESS OF ENVIRONMENTAL TEMPERATURE. THESE FINDINGS HIGHLIGHT THE EFFICACY OF YOGA POSTURES IN PRODUCING IMPROVEMENTS IN VASCULAR HEALTH AND DOWNPLAY THE NECESSITY OF THE HEATED PRACTICE ENVIRONMENT IN INDUCING VASCULAR ADAPTATIONS. ABSTRACT: WE HAVE PREVIOUSLY DOCUMENTED IMPROVEMENTS IN ENDOTHELIUM-DEPENDENT VASODILATATION WITH A BIKRAM (HOT) YOGA INTERVENTION IN MIDDLE-AGED ADULTS. AT PRESENT, THE EFFECT OF ENVIRONMENTAL TEMPERATURE IN HOT YOGA ON ENDOTHELIAL FUNCTION IS UNKNOWN. THE PURPOSE OF THIS INVESTIGATION WAS TO DETERMINE THE EFFECTS OF BIKRAM YOGA INTERVENTIONS PERFORMED IN HEATED OR THERMONEUTRAL CONDITIONS ON ENDOTHELIUM-DEPENDENT VASODILATATION. FIFTY-TWO SEDENTARY BUT APPARENTLY HEALTHY ADULTS AGED 40-60 YEARS WERE RANDOMLY ASSIGNED TO ONE OF THREE GROUPS: BIKRAM YOGA PRACTISED AT 40.5 DEGREES C (N = 19), BIKRAM YOGA PRACTISED AT 23 DEGREES C (N = 14) OR SEDENTARY TIME CONTROL (N = 19). THE YOGA INTERVENTIONS CONSISTED OF 90 MIN BIKRAM YOGA CLASSES THREE TIMES A WEEK FOR 12 WEEKS. ENDOTHELIUM-DEPENDENT VASODILATATION WAS MEASURED NON-INVASIVELY USING BRACHIAL ARTERY FLOW-MEDIATED DILATATION (FMD). BODY FAT PERCENTAGE DETERMINED VIA DUAL-ENERGY X-RAY ABSORPTIOMETRY WAS SIGNIFICANTLY LOWER IN THE HOT YOGA GROUP AFTER THE INTERVENTION THAN IN THE THERMONEUTRAL YOGA AND CONTROL CONDITIONS. BRACHIAL ARTERY FMD INCREASED (P < 0.05) IN THE THERMONEUTRAL YOGA GROUP AND TENDED TO INCREASE IN THE HOT YOGA GROUP (P = 0.056). NO CHANGES OCCURRED IN THE CONTROL GROUP. THERE WERE NO SIGNIFICANT DIFFERENCES IN FMD CHANGE SCORES BETWEEN GROUPS. WE CONCLUDE THAT BIKRAM YOGA PRACTISED IN THERMONEUTRAL CONDITIONS IMPROVED ENDOTHELIUM-DEPENDENT VASODILATATION IN HEALTHY, MIDDLE-AGED ADULTS. THESE NEW FINDINGS HIGHLIGHT THE EFFECTIVENESS OF HATHA YOGA POSTURES ALONE, IN THE ABSENCE OF A HEATED PRACTICE ENVIRONMENT, IN IMPROVING VASCULAR HEALTH AND ARE OF CLINICAL SIGNIFICANCE GIVEN THE INCREASED PROPENSITY FOR HEAT INTOLERANCE IN AGEING ADULTS. 2018
7 2009 33 SUBJECTIVE SLEEP QUALITY AND HORMONAL MODULATION IN LONG-TERM YOGA PRACTITIONERS. YOGA REPRESENTS A FASCINATING MIND-BODY APPROACH, WHEREIN BODY MOVEMENTS (ASANA), BREATHING EXERCISES (PRANAYAMA) AND MEDITATION ARE INTEGRATED INTO A SINGLE MULTIDIMENSIONAL PRACTICE. NUMEROUS BENEFICIAL MENTAL AND PHYSICAL EFFECTS HAVE BEEN CLASSICALLY ASCRIBED TO THIS HOLISTIC ANCIENT METHOD. THE PURPOSE OF THE PRESENT STUDY HAS BEEN TO EXAMINE THE EFFECTS OF LONG-TERM YOGA PRACTICE ON SUBJECTIVE SLEEP QUALITY (SSQ) AND ON SEVERAL HORMONAL PARAMETERS OF THE HYPOTHALAMUS-PITUITARY-ADRENAL (HPA) AXIS. TWENTY-SIX SUBJECTS (16 EXPERIMENTAL AND 10 CONTROLS) WERE RECRUITED TO BE PART OF THE STUDY. EXPERIMENTAL SUBJECTS WERE REGULAR YOGA PRACTITIONERS WITH A MINIMUM OF 3 YEARS OF PRACTICE. BLOOD SAMPLES FOR THE QUANTIFICATION OF ADRENOCORTICOTROPIC HORMONE (ACTH), CORTISOL AND DEHYDROEPIANDROSTERONE SULPHATE (DHEA-S) WERE DRAWN FROM ALL SUBJECTS. LIKEWISE, THE PITTSBURGH SLEEP QUALITY INDEX (PSQI) WAS EMPLOYED TO ASSESS SSQ. AS STATISTICAL ANALYSIS, MANN-WHITNEY U-TEST WAS PERFORMED. THE YOGA GROUP DISPLAYED LOWER PSQI SCORES AND HIGHER BLOOD CORTISOL LEVELS THAN CONTROL SUBJECTS. THEREFORE, IT CAN BE CONCLUDED THAT LONG-TERM YOGA PRACTICE IS ASSOCIATED WITH SIGNIFICANT PSYCHO-BIOLOGICAL DIFFERENCES, INCLUDING BETTER SLEEP QUALITY AS WELL AS A MODULATORY ACTION ON THE LEVELS OF CORTISOL. THESE PRELIMINARY RESULTS SUGGEST INTERESTING CLINICAL IMPLICATIONS WHICH SHOULD BE FURTHER RESEARCHED. 2009
8 2819 29 YOGA TRAINING MODULATES ADIPOKINES IN ADULTS WITH HIGH-NORMAL BLOOD PRESSURE AND METABOLIC SYNDROME. METABOLIC SYNDROME (METS) IS ASSOCIATED WITH DIABETES MELLITUS AND CARDIOVASCULAR DISEASES. OUR PREVIOUS STUDY INDICATED THAT PEOPLE WITH METS SHOWED A DECREASE IN WAIST CIRCUMFERENCE AND A DECREASING TREND IN BLOOD PRESSURE AFTER 1-YEAR YOGA. THIS STUDY INVESTIGATED THE EFFECT OF YOGA ON METS PEOPLE WITH HIGH-NORMAL BLOOD PRESSURE BY EXPLORING MODULATIONS IN PROINFLAMMATORY ADIPOKINES (LEPTIN, CHEMERIN, VISFATIN, AND PLASMINOGEN ACTIVATOR INHIBITOR-1 OR PAI-1) AND AN ANTI-INFLAMMATORY ADIPOKINE (ADIPONECTIN). A TOTAL OF 97 HONG KONG CHINESE INDIVIDUALS AGED 57.6 +/- 9.1 YEARS WITH METS AND HIGH-NORMAL BLOOD PRESSURE WERE RANDOMLY ASSIGNED TO CONTROL (N = 45) AND YOGA GROUPS (N = 52). PARTICIPANTS IN THE CONTROL GROUP WERE NOT GIVEN ANY INTERVENTION BUT WERE CONTACTED MONTHLY TO MONITOR THEIR HEALTH STATUS. PARTICIPANTS IN THE YOGA GROUP UNDERWENT A YOGA TRAINING PROGRAM WITH THREE 1-HOUR YOGA SESSIONS WEEKLY FOR 1 YEAR. THE PARTICIPANTS' SERA WERE HARVESTED AND ASSESSED FOR ADIPOKINES. GENERALIZED ESTIMATING EQUATION (GEE) WAS USED TO EXAMINE THE INTERACTION EFFECT BETWEEN 1-YEAR TIME (PRE VS POST), AND INTERVENTION (CONTROL VS YOGA). GEE ANALYSES REVEALED SIGNIFICANT INTERACTION EFFECTS BETWEEN 1-YEAR TIME AND YOGA INTERVENTION FOR THE DECREASES IN LEPTIN AND CHEMERIN AND THE INCREASE IN ADIPONECTIN CONCENTRATION IN THE SERA EXAMINED. THESE RESULTS DEMONSTRATED THAT 1-YEAR YOGA TRAINING DECREASED PROINFLAMMATORY ADIPOKINES AND INCREASED ANTI-INFLAMMATORY ADIPOKINE IN ADULTS WITH METS AND HIGH-NORMAL BLOOD PRESSURE. THESE FINDINGS SUPPORT THE BENEFICIAL ROLE OF YOGA IN MANAGING METS BY FAVORABLY MODULATING ADIPOKINES. 2018
9 433 15 CAN YOGA THERAPY STIMULATE STEM CELL TRAFFICKING FROM BONE MARROW? IT HAS BEEN ESTABLISHED THAT MESENCHYMAL STROMAL CELLS (MSCS) FROM BONE MARROW ENTER THE PERIPHERAL CIRCULATION INTERMITTENTLY FOR POSSIBLE TISSUE REGENERATION, REPAIR AND TO TAKE CARE OF DAILY WEAR AND TEAR. THIS IS EVIDENT FROM THE DETECTION OF MSCS FROM PERIPHERAL BLOOD. THE FACTORS GOVERNING THIS MIGRATION REMAIN ELUSIVE. THESE MSCS CARRY OUT THE WORK OF POLICING AND ARE SUPPOSED TO REPAIR THE INJURED TISSUES. THUS, THESE CELLS HELP IN MAINTAINING THE TISSUE AND ORGAN HOMEOSTASIS. YOGA AND PRANAYAMA ORIGINATED IN INDIA AND IS NOW BEING PRACTICED ALL OVER THE WORLD FOR POSITIVE HEALTH. SO FAR, THE CHEMICAL STIMULATION OF BONE MARROW HAS BEEN WIDELY USED EMPLOYING INJECTION OF COLONY STIMULATING FACTOR. HOWEVER, THE ROLE OF PHYSICAL FACTORS SUCH AS MECHANICAL STIMULATION AND STRETCHING HAS NOT BEEN SUBSTANTIATED. IT IS CLAIMED THAT PRACTICING YOGA DELAYS SENESCENCE, IMPROVES THE PHYSIOLOGICAL FUNCTIONS OF HEART AND LUNG AND YOGA POSTURES MAKE THE BODY ELASTIC. IT REMAINS TO BE SEEN WHETHER THE YOGA THERAPY PROMOTES TRAFFICKING OF THE STEM CELLS FROM BONE MARROW FOR POSSIBLE REPAIR AND REGENERATION OF WORN OUT AND DEGENERATING TISSUES. WE COVER IN THIS SHORT REVIEW, MAINLY THE ROLE OF PHYSICAL FACTORS ESPECIALLY THE YOGA THERAPY ON STEM CELLS TRAFFICKING FROM BONE MARROW. 2016
10 268 40 ACUTE PHYSIOLOGIC EFFECTS OF PERFORMING YOGA IN THE HEAT ON ENERGY EXPENDITURE, RANGE OF MOTION, AND INFLAMMATORY BIOMARKERS. PERFORMING YOGA IN A HEATED ENVIRONMENT (HY) IS A POPULAR EXERCISE MODE PURPORTED TO IMPROVE RANGE OF MOTION (ROM), BODY COMPOSITION, AND AEROBIC FITNESS. THE PURPOSE OF THIS INVESTIGATION WAS TO COMPARE A SESSION OF HY TO ROOM TEMPERATURE YOGA (RTY) WITH REGARDS TO ROM, OXYGEN CONSUMPTION, CALORIC EXPENDITURE, AND BIOMARKERS OF ACUTE STRESS AND INFLAMMATION. SIXTEEN EXPERIENCED YOGA PRACTITIONERS (F14, M2; 40 +/- 11YR; 22.6 +/- 1.8 KG/M(2)) COMPLETED A 1-HOUR STANDARDIZED BIKRAM SEQUENCE IN HY (105 DEGREES F, 40 DEGREES C) AND RTY (74 DEGREES F, 23.3 DEGREES C) CONDITIONS (ORDER OF CONDITIONS RANDOMIZED, HUMIDITY STANDARDIZED AT 40%). INTRA-EXERCISE METABOLIC GAS EXCHANGE AND HEART RATE (HR) WAS MONITORED USING A METABOLIC CART. ROM MEASURES WERE TAKEN PRE AND POST-EXERCISE AT THE ELBOW, SHOULDER, HIP, AND KNEE. CYTOKINES INTERLEUKIN 6,10 (IL-6, IL-10) AND TUMOR-NECROSIS-FACTOR ALPHA (TNF-ALPHA) WERE ANALYZED FROM BLOOD SAMPLES COLLECTED PRE- AND 30-MINUTES POST-EXERCISE. INTRA-EXERCISE METABOLIC GAS EXCHANGE AND HEART RATE (HR) WAS MONITORED USING A METABOLIC CART. BOTH BOUTS ELICITED SIMILAR ACUTE CHANGES IN ROM ALTHOUGH HY ELICITED A GREATER INCREASE IN HIP ABDUCTION (RTYDELTA DEGREES = 2.3 +/- 1.3|HYDELTA DEGREES = 6.6 +/- 1.5; P < 0.05). MEAN VO2, PEAK VO2, %VO2MAX, HR, AND KCAL EXPENDITURE DID NOT DIFFER BETWEEN CONDITIONS. RER WAS LOWER DURING THE HY (RTY = 0.95 +/- 0.02| HY = 0.89 +/- 0.02; P < 0.05) WITH A CONCOMITANT ELEVATION IN FAT OXIDATION (RTY = 0.05 +/- 0.01|HY = 0.09 +/- 0.01, G.MIN(-1); P < 0.05) AND DECREASE IN CARBOHYDRATE OXIDATION (RTY = 0.51 +/- 0.04|HY = 0.44 +/- 0.03, G.MIN(-1); P < 0.05). SERUM IL-6 WAS INCREASED (15.5 +/- 8.0-FOLD) FOLLOWING HY ONLY (P < 0.05). HY DOES NOT SIGNIFICANTLY ELEVATE AEROBIC ENERGY COST COMPARED TO RTY BUT MAY ACUTELY INCREASE FAT SUBSTRATE UTILIZATION AND HIP ROM. FUTURE STUDIES REMAIN NEEDED TO ESTABLISH DOSE-RESPONSE RELATIONSHIPS FOR INCLUDING HY OR RTY INTO WELL-ROUNDED FITNESS PROGRAMS. 2020
11 569 16 DECREASE IN SERUM CORTISOL DURING YOGA EXERCISE IS CORRELATED WITH ALPHA WAVE ACTIVATION. WE EXAMINED CHANGES IN BRAIN WAVES AND BLOOD LEVELS OF SERUM CORTISOL DURING YOGA EXERCISE IN 7 YOGA INSTRUCTORS AND FOUND THAT ALPHA WAVES INCREASED AND SERUM CORTISOL DECREASED. THESE TWO MEASURES WERE NEGATIVELY CORRELATED (R = -.83). COMPARISON WITH A CONTROL GROUP OF NONPRACTITIONERS IS DESIRABLE. 2000
12 2759 29 YOGA PRACTITIONERS EXHIBIT HIGHER PARASYMPATHETIC ACTIVITY AND BAROREFLEX SENSITIVITY AND BETTER ADAPTABILITY TO 40 MM HG LOWER-BODY NEGATIVE PRESSURE. YOGA HAS BEEN SHOWN TO IMPROVE AUTONOMIC CONDITIONING IN HUMANS, AS EVIDENCED BY THE ENHANCEMENT OF PARASYM-PATHETIC ACTIVITY AND BAROREFLEX SENSITIVITY. THEREFORE, WE HYPOTHESIZED THAT THE EXPERIENCE OF YOGA MAY RESULT IN ADAPTATION TO ACUTE HEMODYNAMIC CHANGES. TO DECIPHER THE LONG-TERM EFFECTS OF YOGA ON CARDIOVASCULAR VARIABILITY, YOGA PRACTITIONERS WERE COMPARED TO YOGA-NAIVE SUBJECTS DURING EXPOSURE TO -40 MM HG LOWER-BODY NEGATIVE PRESSURE (LBNP). A COMPARATIVE STUDY WAS CONDUCTED ON 40 YOGANAIVE SUBJECTS AND 40 YOGA PRACTITIONERS WITH AN AVERAGE AGE OF 31.08 +/- 7.31 YEARS AND 29.93 +/- 7.57 YEARS, RESPECTIVELY. HEART RATE VARIABILITY, BLOOD PRESSURE VARIABILITY, BAROREFLEX SENSITIVITY, AND CORRELATION BETWEEN SYSTOLIC BLOOD PRESSURE AND RR INTERVAL WERE EVALUATED AT REST AND DURING LBNP. IN YOGA PRACTITIONERS, THE HEART RATE WAS LOWER IN SUPINE REST (P = 0.011) AND DURING LBNP (P = 0.043); THE PNN50 MEASURE OF HEART RATE VARIABILITY WAS HIGHER IN SUPINE REST (P = 0.011) AND DURING LBNP (P = 0.034). THE YOGA PRACTITIONERS' STANDARD DEVIATION OF SUCCESSIVE BEAT-TO-BEAT BLOOD PRESSURE INTERVALS OF SYSTOLIC BLOOD PRESSURE VARIABILITY WAS LOWER IN SUPINE REST (P = 0.034) AND DURING LBNP (P = 0.007), WITH HIGHER SEQUENCE BAROREFLEX SENSITIVITY (P = 0.019) AND ~ HIGH-FREQUENCY BAROREFLEX SENSITIVITY. MEAN SYSTOLIC BLOOD PRESSURE AND RR INTERVAL WERE INVERSELY CORRELATED IN THE YOGA GROUP (R = -0.317, P = 0.049). THE YOGA PRACTITIONERS EXHIBITED HIGHER PARASYMPATHETIC ACTIVITY AND BAROREFLEX SENSITIVITY WITH LOWER SYSTOLIC BLOOD PRESSURE VARIABILITY, INDICATING BETTER ADAPTABILITY TO LBNP COMPARED TO THE YOGA-NAIVE GROUP. OUR FINDINGS INDICATE THAT THE YOGA MODULE WAS HELPFUL IN CONDITIONS OF HYPOVOLEMIA IN HEALTHY SUBJECTS; IT IS PROPOSED TO BE BENEFICIAL IN CLINICAL CONDITIONS ASSOCIATED WITH SYMPATHETIC DOMINANCE, IMPAIRED BARORE-FLEX SENSITIVITY, AND ORTHOSTATIC INTOLERANCE. 2021
13 454 28 CHANGES IN MIDLATENCY AUDITORY EVOKED POTENTIALS FOLLOWING TWO YOGA-BASED RELAXATION TECHNIQUES. PRACTICING MEDITATION WHILE FOCUSING ON A SOUND OR A SYMBOL INFLUENCED MIDLATENCY AUDITORY EVOKED POTENTIALS (MLAEPS). CYCLIC MEDITATION (CM) IS A TECHNIQUE COMBINING YOGA POSTURES WITH MEDITATION WHILE SUPINE, WHICH HAS INFLUENCED THE P300 EVENT-RELATED POTENTIAL. THE EFFECTS OF CM ON MLAEPS HAVE NOT BEEN PREVIOUSLY STUDIED. THE MLAEPS WERE STUDIED BEFORE AND AFTER THE PRACTICE OF CM COMPARED TO AN EQUAL DURATION OF SUPINE REST (SR) IN 47 MALE VOLUNTEERS (GROUP MEAN AGE 26.5 +/- 4.4 YEARS), RECORDED FROM THE VERTEX REFERENCED TO LINKED EARLOBES. THE SESSIONS WERE ONE DAY APART AND SUBJECTS WERE RANDOMLY ASSIGNED TO EACH SESSION. THE PA WAVE PEAK LATENCY AND NB WAVE PEAK LATENCY SIGNIFICANTLY INCREASED FOLLOWING CM COMPARED TO BEFORE CM (REPEATED MEASURES ANOVA, POST-HOC ANALYSIS WITH LEAST SIGNIFICANT DIFFERENCE, P<0.05). THERE WAS A SIGNIFICANT INCREASE IN THE PEAK AMPLITUDE OF THE NB WAVE (P<0.05) COMPARED TO BEFORE CM. POST SR THERE WAS A SIGNIFICANT INCREASE IN THE PEAK LATENCY OF THE NA WAVE (P<0.05) COMPARED TO BEFORE SR. IN CONCLUSION FOLLOWING CM THE LATENCIES OF NEURAL GENERATORS CORRESPONDING TO CORTICAL AREAS IS PROLONGED, WHEREAS FOLLOWING SR A SIMILAR CHANGE OCCURS AT MESENCEPHALIC-DIENCEPHALIC LEVELS. 2009
14 1889 35 REGULAR YOGA PRACTICE IMPROVES ANTIOXIDANT STATUS, IMMUNE FUNCTION, AND STRESS HORMONE RELEASES IN YOUNG HEALTHY PEOPLE: A RANDOMIZED, DOUBLE-BLIND, CONTROLLED PILOT STUDY. OBJECTIVE: THE AIM OF THE PRESENT STUDY IS TO HIGHLIGHT THE BENEFICIAL EFFECTS OF YOGA PRACTICE ON BIO-PARAMETERS, SUCH AS OXIDATIVE STRESS, ANTIOXIDANT COMPONENTS, IMMUNE FUNCTIONS, AND SECRETION OF STRESS HORMONES, IN HEALTHY YOUNG PEOPLE. STUDY DESIGN: THIS STUDY WAS CONDUCTED ON HEALTHY VOLUNTEERS RECRUITED FROM AMONG UNIVERSITY STUDENTS, WHO WERE DIVIDED INTO TWO GROUPS: A CONTROL (NO YOGA INTERVENTION, N=13) GROUP AND A YOGA (N=12) GROUP. YOGA PRACTICE WAS WITH AN INSTRUCTOR FOR 90 MINUTES ONCE A WEEK SPREAD OVER 12 WEEKS, WITH RECOMMENDATIONS TO PRACTICE DAILY AT HOME FOR 40 MINUTES WITH THE HELP OF A DVD. THE YOGA PROGRAM CONSISTED OF YOGA BODY POSES (ASANAS), EXERCISES INVOLVING AWARENESS, VOLUNTARY REGULATION OF BREATH (PRANAYAMA), AND MEDITATIONAL PRACTICES. WHOLE BLOOD SAMPLES WERE COLLECTED WHEN THE VOLUNTEERS HAD FASTED FOR 8 HOURS AT 0 AND 12 WEEKS. THE OXIDATIVE STRESS/ANTIOXIDANT COMPONENTS, IMMUNE-RELATED CYTOKINES, AND STRESS HORMONES WERE EVALUATED IN SERUM OR PLASMA. RESULTS: SERUM LEVELS OF NITRIC OXIDE, F2-ISOPROSTANE, AND LIPID PEROXIDE WERE SIGNIFICANTLY DECREASED BY YOGA PRACTICE (P<0.05 OR P=0.01), WHEREAS SERUM TOTAL GLUTATHIONE (GSH) CONTENTS, ACTIVITIES OF GSH-PEROXIDASE, AND GSH-S-TRANSFERASE WERE REMARKABLY INCREASED AFTER YOGA PRACTICE COMPARED WITH THE CONTROL GROUP (P<0.05 OR P=0.01). YOGA PRACTICE ALSO SIGNIFICANTLY INCREASED IMMUNE-RELATED CYTOKINES, SUCH AS INTERLEUKIN-12, AND INTERFERON-GAMMA, IN SERUM (P<0.05 OR P=0.01). YOGA PRACTICE SIGNIFICANTLY REDUCED THE PLASMA LEVELS OF ADRENALIN (P<0.05) AND INCREASED PLASMA LEVELS OF SEROTONIN COMPARED WITH THE CONTROL GROUP (P<0.05). CONCLUSIONS: REGULAR YOGA PRACTICE REMARKABLY ATTENUATED OXIDATIVE STRESS AND IMPROVED ANTIOXIDANT LEVELS OF THE BODY. MOREOVER, YOGA BENEFICIALLY AFFECTED STRESS HORMONE RELEASES AS WELL AS PARTIALLY IMPROVED IMMUNE FUNCTION. 2015
15 458 30 CHANGES IN P300 FOLLOWING TWO YOGA-BASED RELAXATION TECHNIQUES. CYCLIC MEDITATION (CM) IS A TECHNIQUE THAT COMBINES "STIMULATING" AND "CALMING" PRACTICES, BASED ON A STATEMENT IN ANCIENT YOGA TEXTS SUGGESTING THAT SUCH A COMBINATION MAY BE ESPECIALLY HELPFUL TO REACH A STATE OF MENTAL EQUILIBRIUM. THE CHANGES IN THE PEAK LATENCY AND PEAK AMPLITUDE OF P300 AUDITORY EVENT-RELATED POTENTIALS WERE STUDIED BEFORE AND AFTER THE PRACTICE OF CYCLIC MEDITATION COMPARED TO AN EQUAL DURATION OF SUPINE REST IN 42 VOLUNTEERS (GROUP MEAN AGE +/- SD, 27 +/- 6.3 YEARS), FROM FZ, CZ, AND PZ ELECTRODE SITES REFERENCED TO LINKED EARLOBES. THE SESSIONS WERE ONE DAY APART AND THE ORDER WAS ALTERNATED. THERE WAS REDUCTION IN THE PEAK LATENCIES OF P300 AFTER CYCLIC MEDITATION AT FZ, CZ, AND PZ COMPARED TO THE "PRE" VALUES. A SIMILAR TREND OF REDUCTION IN P300 PEAK LATENCIES AT FZ, CZ, AND PZ WAS ALSO OBSERVED AFTER SUPINE REST, COMPARED TO THE RESPECTIVE "PRE" VALUES, ALTHOUGH THE MAGNITUDE OF CHANGE IN EACH CASE WAS LESS AFTER SUPINE REST COMPARED TO AFTER CYCLIC MEDITATION. THE P300 PEAK AMPLITUDES AFTER CM WERE HIGHER AT FZ, CZ, AND PZ SITES COMPARED TO THE "PRE" VALUES. IN CONTRAST, NO SIGNIFICANT CHANGES WERE OBSERVED IN THE P300 PEAK AMPLITUDES AT FZ, CZ, AND PZ AFTER SUPINE REST COMPARED TO THE RESPECTIVE "PRE" STATE. THE PRESENT RESULTS SUPPORT THE IDEA THAT "CYCLIC" MEDITATION ENHANCES COGNITIVE PROCESSES UNDERLYING THE GENERATION OF THE P300. 2006
16 2816 30 YOGA TRAINING IMPROVES METABOLIC PARAMETERS IN OBESE BOYS. YOGA HAS BEEN KNOWN TO HAVE STIMULATORY OR INHIBITORY EFFECTS ON THE METABOLIC PARAMETERS AND TO BE UNCOMPLICATED THERAPY FOR OBESITY. THE PURPOSE OF THE PRESENT STUDY WAS TO TEST THE EFFECT OF AN 8-WEEK OF YOGA-ASANA TRAINING ON BODY COMPOSITION, LIPID PROFILE, AND INSULIN RESISTANCE (IR) IN OBESE ADOLESCENT BOYS. TWENTY VOLUNTEERS WITH BODY MASS INDEX (BMI) GREATER THAN THE 95TH PERCENTILE WERE RANDOMLY ASSIGNED TO YOGA (AGE 14.7+/-0.5 YEARS, N=10) AND CONTROL GROUPS (AGE 14.6+/-1.0 YEARS, N=10). THE YOGA GROUP PERFORMED EXERCISES THREE TIMES PER WEEK AT 40~60% OF HEART-RATE RESERVE (HRR) FOR 8 WEEKS. IR WAS DETERMINED WITH THE HOMEOSTASIS MODEL ASSESSMENT OF INSULIN RESISTANCE (HOMA-IR). AFTER YOGA TRAINING, BODY WEIGHT, BMI, FAT MASS (FM), AND BODY FAT % (BF %) WERE SIGNIFICANTLY DECREASED, AND FAT-FREE MASS AND BASAL METABOLIC RATE WERE SIGNIFICANTLY INCREASED THAN BASELINE VALUES. FM AND BF % WERE SIGNIFICANTLY IMPROVED IN THE YOGA GROUP COMPARED WITH THE CONTROL GROUP (P<0.05). TOTAL CHOLESTEROL (TC) WAS SIGNIFICANTLY DECREASED IN THE YOGA GROUP (P<0.01). HDL-CHOLESTEROL WAS DECREASED IN BOTH GROUPS (P<0.05). NO SIGNIFICANT CHANGES WERE OBSERVED BETWEEN OR WITHIN GROUPS FOR TRIGLYCERIDES, LDL-CHOLESTEROL, GLUCOSE, INSULIN, AND HOMA-IR. OUR FINDINGS SHOW THAT AN 8-WEEK OF YOGA TRAINING IMPROVES BODY COMPOSITION AND TC LEVELS IN OBESE ADOLESCENT BOYS, SUGGESTING THAT YOGA TRAINING MAY BE EFFECTIVE IN CONTROLLING SOME METABOLIC SYNDROME FACTORS IN OBESE ADOLESCENT BOYS. 2012
17 326 33 ANTIDEPRESSANT EFFICACY AND HORMONAL EFFECTS OF SUDARSHANA KRIYA YOGA (SKY) IN ALCOHOL DEPENDENT INDIVIDUALS. BACKGROUND: SUDARSHANA KRIYA YOGA (SKY) HAS DEMONSTRABLE ANTIDEPRESSANT EFFECTS. SKY WAS TESTED FOR THIS EFFECT IN INPATIENTS OF ALCOHOL DEPENDENCE. METHODS: FOLLOWING A WEEK OF DETOXIFICATION MANAGEMENT CONSENTING SUBJECTS (N=60) WERE EQUALLY RANDOMIZED TO RECEIVE SKY THERAPY OR NOT (CONTROLS) FOR A TWO-WEEK STUDY. SKY THERAPY INCLUDED ALTERNATE DAY PRACTICE OF SPECIFIED BREATHING EXERCISE UNDER SUPERVISION OF A TRAINED THERAPIST. SUBJECTS COMPLETED THE BECK DEPRESSION INVENTORY (BDI) BEFORE AND AFTER THE TWO WEEKS OF THIS INTERVENTION. MORNING PLASMA CORTISOL, ACTH AND PROLACTIN TOO WERE MEASURED BEFORE AND AT THE END OF TWO WEEKS. RESULTS: IN BOTH GROUPS REDUCTIONS IN BDI SCORES OCCURRED BUT SIGNIFICANTLY MORE SO IN SKY GROUP. LIKEWISE, IN BOTH GROUPS PLASMA CORTISOL AS WELL AS ACTH FELL AFTER TWO WEEKS BUT SIGNIFICANTLY MORE SO IN SKY GROUP. REDUCTION IN BDI SCORES CORRELATED WITH THAT IN CORTISOL IN SKY BUT NOT IN CONTROL GROUP. LIMITATIONS: ANTIDEPRESSANT EFFECTS OF SKY WERE DEMONSTRATED IN EARLY ABSTINENCE THAT ALSO HAD SUBSTANTIAL SPONTANEOUS IMPROVEMENT. IT IS NOT KNOWN IF THIS EFFECT CONTRIBUTES TO SUSTAINED ABSTINENCE. CONCLUSION: RESULTS EXTEND THE ANTIDEPRESSANT EFFECTS OF SKY IN ALCOHOL DEPENDENCE SUBJECTS. REDUCTION IN STRESS-HORMONE LEVELS (CORTISOL AND ACTH) ALONG WITH BDI REDUCTIONS POSSIBLY SUPPORT A BIOLOGICAL MECHANISM OF SKY IN PRODUCING BENEFICIAL EFFECTS. 2006
18 1149 26 ENHANCEMENT OF CANCER STEM CELL SUSCEPTIBILITY TO CONVENTIONAL TREATMENTS THROUGH COMPLEMENTARY YOGA THERAPY: POSSIBLE CELLULAR AND MOLECULAR MECHANISMS. CANCER STEM CELLS (CSCS) ARE STEM-LIKE TUMOR POPULATIONS THAT ARE REPORTED TO CONTRIBUTE TOWARDS TUMOR GROWTH, MAINTENANCE AND RECURRENCE AFTER THERAPY. HYPOXIA INCREASES CSC FRACTION AND PROMOTES ACQUISITION OF A STEM-CELL-LIKE STATE. CANCER STEM CELLS ARE CRITICALLY DEPENDANT ON THE HYPOXIA-INDUCIBLE FACTOR-1 (HIF-1) FOR SURVIVAL, SELF-RENEWAL, TUMOR GROWTH AND MAINTENANCE OF THEIR UNDIFFERENTIATED PHENOTYPE. RECENT RESEARCHES SHOW THAT STAGE OF DIFFERENTIATION OF THE TUMOR CELLS IS PREDICTIVE OF THEIR SUSCEPTIBILITY TO NATURAL KILLER CELL (NK) CELL MEDIATED CYTOTOXICITY AND CANCER STEM CELLS ARE SIGNIFICANT TARGETS OF NK CELL CYTOTOXICITY. STUDIES ALSO SHOW THAT REVERSION OF TUMOR CELLS TO A LESS-DIFFERENTIATED PHENOTYPE CAN BE ACHIEVED BY BLOCKING NFKAPPAB. YOGA THERAPY (YOGIC LIFESTYLE MODIFICATIONS ENCOMPASSING PHYSICAL POSTURES, BREATHING PRACTICES, RELAXATION TECHNIQUES AND MEDITATIONS) IS KNOWN TO MODULATE NEURAL, ENDOCRINE AND IMMUNE FUNCTIONS AT THE CELLULAR LEVEL THROUGH INFLUENCING CELL CYCLE CONTROL, AGING, OXIDATIVE STRESS, APOPTOSIS AND SEVERAL PATHWAYS OF STRESS SIGNALING MOLECULES. YOGA THERAPY HAS ALSO BEEN SHOWN TO ENHANCE NATURAL KILLER CELL ACTIVITY AND MODULATE STRESS AND DNA DAMAGE IN BREAST CANCER PATIENTS RECEIVING RADIOTHERAPY. RECENT STUDY FOUND THAT BRIEF DAILY YOGIC MEDITATION MAY REVERSE THE PATTERN OF INCREASED NFKAPPAB-RELATED TRANSCRIPTION OF PRO-INFLAMMATORY CYTOKINES IN LEUKOCYTES. THUS, YOGA THERAPY HAS THE POTENTIAL TO REDUCE CANCER STEM CELL SURVIVAL, SELF -RENEWAL AND TUMOR GROWTH BY MODIFYING THE TUMOR MICRO-ENVIRONMENT THROUGH VARIOUS MECHANISMS SUCH AS; 1) REDUCING HIF-1 ACTIVITY BY ENHANCED OXYGENATION, 2) PROMOTING NK CELL ACTIVITY DIRECTLY (OR INDIRECTLY THROUGH DOWN REGULATING NFKAPPAB EXPRESSION), THEREBY ENHANCING NK CELL MEDIATED CSC LYSIS, AND 3) BY MINIMIZING THE ABERRANT EXPRESSIONS OR ACTIVITIES OF VARIOUS HORMONES, CYTOKINES, CHEMOKINES AND TUMOR SIGNALING PATHWAYS. YOGA THERAPY MAY HAVE A SYNERGISTIC EFFECT WITH CONVENTIONAL MODALITIES OF TREATMENT IN PREVENTING CANCER PROGRESSION AND RECURRENCES. 2012
19 1649 33 MULTI-OMICS INTEGRATION AND INTERACTOMICS REVEALS MOLECULAR NETWORKS AND REGULATORS OF THE BENEFICIAL EFFECT OF YOGA AND EXERCISE. BACKGROUND: YOGA IS A MULTIFACETED SPIRITUAL TOOL THAT HELPS IN MAINTAINING HEALTH, PEACE OF MIND, AND POSITIVE THOUGHTS. IN THE CONTEXT OF ASANA, YOGA IS SIMILAR TO PHYSICAL EXERCISE. THIS STUDY AIMS TO CONSTRUCT A MOLECULAR NETWORK TO FIND HUB GENES THAT PLAY IMPORTANT ROLES IN PHYSICAL EXERCISE AND YOGA. METHODOLOGY: WE COMBINED DIFFERENTIALLY EXPRESSED GENES (DEGS) IN YOGA AND EXERCISE USING COMPUTATIONAL BIOINFORMATICS FROM PUBLICLY AVAILABLE GENE EXPRESSION OMNIBUS (GEO) DATASETS AND IDENTIFIED THE CODIFFERENTIALLY EXPRESSED MRNAS WITH GEO2R. THE CO-DEGS WERE DIVIDED INTO FOUR DIFFERENT GROUPS AND EACH GROUP WAS SUBJECTED TO PROTEIN-PROTEIN INTERACTION (PPI) NETWORK, PATHWAYS ANALYSIS, AND GENE ONTOLOGY. RESULTS: OUR STUDY IDENTIFIED IMMUNOLOGICAL MODULATION AS A DOMINANT TARGET OF DIFFERENTIAL EXPRESSION IN YOGA AND EXERCISE. YOGA PREDOMINANTLY MODULATED GENES AFFECTING THE TH1 AND NK CELLS, WHEREAS CYTOKINES, MACROPHAGE ACTIVATION, AND OXIDATIVE STRESS WERE AFFECTED BY EXERCISE. WE ALSO OBSERVED THAT WHILE YOGA REGULATED GENES FOR TWO MAIN PHYSIOLOGICAL FUNCTIONS OF THE BODY, NAMELY CIRCADIAN RHYTHM (BHLHE40) AND IMMUNITY (LBP, T-BOX TRANSCRIPTION FACTOR 21, CEACAM1), EXERCISE-REGULATED GENES INVOLVED IN APOPTOSIS (BAG3, PROTEIN KINASE C ALPHA), ANGIOGENESIS, AND CELLULAR ADHESION (EPH RECEPTOR A1). CONCLUSION: THE DISSIMILARITY IN THE GENETIC EXPRESSION PATTERNS IN YOGA AND EXERCISE HIGHLIGHTS THE DISCRETE EFFECT OF EACH IN BIOLOGICAL SYSTEMS. THE INTEGRATION AND CONVERGENCES OF MULTI-OMICS SIGNALS CAN PROVIDE DEEPER AND COMPREHENSIVE INSIGHTS INTO THE VARIOUS BIOLOGICAL MECHANISMS THROUGH WHICH YOGA AND EXERCISE EXERT THEIR BENEFICIAL EFFECTS AND OPENS UP POTENTIAL NEWER RESEARCH AREAS. 2022
20 1639 18 MODULATION OF IMMUNE RESPONSES IN STRESS BY YOGA. STRESS IS A CONSTANT FACTOR IN TODAY'S FASTPACED LIFE THAT CAN JEOPARDIZE OUR HEALTH IF LEFT UNCHECKED. IT IS ONLY IN THE LAST HALF CENTURY THAT THE ROLE OF STRESS IN EVERY AILMENT FROM THE COMMON COLD TO AIDS HAS BEEN EMPHASIZED, AND THE MECHANISMS INVOLVED IN THIS PROCESS HAVE BEEN STUDIED. STRESS INFLUENCES THE IMMUNE RESPONSE PRESUMABLY THROUGH THE ACTIVATION OF THE HYPOTHALAMIC-PITUITARY ADRENAL AXIS, HYPOTHALAMIC PITUITARY-GONADAL AXIS, AND THE SYMPATHETIC-ADRENAL-MEDULLARY SYSTEM. VARIOUS NEUROTRANSMITTERS, NEUROPEPTIDES, HORMONES, AND CYTOKINES MEDIATE THESE COMPLEX BIDIRECTIONAL INTERACTIONS BETWEEN THE CENTRAL NERVOUS SYSTEM (CNS) AND THE IMMUNE SYSTEM. THE EFFECTS OF STRESS ON THE IMMUNE RESPONSES RESULT IN ALTERATIONS IN THE NUMBER OF IMMUNE CELLS AND CYTOKINE DYSREGULATION. VARIOUS STRESS MANAGEMENT STRATEGIES SUCH AS MEDITATION, YOGA, HYPNOSIS, AND MUSCLE RELAXATION HAVE BEEN SHOWN TO REDUCE THE PSYCHOLOGICAL AND PHYSIOLOGICAL EFFECTS OF STRESS IN CANCERS AND HIV INFECTION. THIS REVIEW AIMS TO DISCUSS THE EFFECT OF STRESS ON THE IMMUNE SYSTEM AND EXAMINE HOW RELAXATION TECHNIQUES SUCH AS YOGA AND MEDITATION COULD REGULATE THE CYTOKINE LEVELS AND HENCE, THE IMMUNE RESPONSES DURING STRESS. 2008