1 1347 180 HYPOXIA IN CNS PATHOLOGIES: EMERGING ROLE OF MIRNA-BASED NEUROTHERAPEUTICS AND YOGA BASED ALTERNATIVE THERAPIES. CELLULAR RESPIRATION IS A VITAL PROCESS FOR THE EXISTENCE OF LIFE. ANY CONDITION THAT RESULTS IN DEPRIVATION OF OXYGEN (ALSO TERMED AS HYPOXIA) MAY EVENTUALLY LEAD TO DELETERIOUS EFFECTS ON THE FUNCTIONING OF TISSUES. BRAIN BEING THE HIGHEST CONSUMER OF OXYGEN IS PRONE TO INCREASED RISK OF HYPOXIA-INDUCED NEUROLOGICAL INSULTS. THIS IN TURN HAS BEEN ASSOCIATED WITH MANY DISEASES OF CENTRAL NERVOUS SYSTEM (CNS) SUCH AS STROKE, ALZHEIMER'S, ENCEPHALOPATHY ETC. ALTHOUGH SEVERAL STUDIES HAVE INVESTIGATED THE PATHOPHYSIOLOGICAL MECHANISMS UNDERLYING ISCHEMIC/HYPOXIC CNS DISEASES, THE KNOWLEDGE ABOUT PROTECTIVE THERAPEUTIC STRATEGIES TO AMELIORATE THE AFFECTED NEURONAL CELLS IS MEAGER. THIS HAS AUGMENTED THE NEED TO IMPROVE OUR UNDERSTANDING OF THE HYPOXIC AND ISCHEMIC EVENTS OCCURRING IN THE BRAIN AND IDENTIFY NOVEL AND ALTERNATE TREATMENT MODALITIES FOR SUCH INSULTS. MICRORNA (MIRNAS), SMALL NON-CODING RNA MOLECULES, HAVE RECENTLY EMERGED AS POTENTIAL NEUROPROTECTIVE AGENTS AS WELL AS TARGETS, UNDER HYPOXIC CONDITIONS. THESE 18-22 NUCLEOTIDE LONG RNA MOLECULES ARE PROFUSELY PRESENT IN BRAIN AND OTHER ORGANS AND FUNCTION AS GENE REGULATORS BY CLEAVING AND SILENCING THE GENE EXPRESSION. IN BRAIN, THESE ARE KNOWN TO BE INVOLVED IN NEURONAL DIFFERENTIATION AND PLASTICITY. THEREFORE, TARGETING MIRNA EXPRESSION REPRESENTS A NOVEL THERAPEUTIC APPROACH TO INTERCEDE AGAINST HYPOXIC AND ISCHEMIC BRAIN INJURY. IN THE FIRST PART OF THIS REVIEW, WE WILL DISCUSS THE NEUROPHYSIOLOGICAL CHANGES CAUSED AS A RESULT OF HYPOXIA, FOLLOWED BY THE CONTRIBUTION OF HYPOXIA IN THE NEURODEGENERATIVE DISEASES. SECONDLY, WE WILL PROVIDE RECENT UPDATES AND INSIGHTS INTO THE ROLES OF MIRNA IN THE REGULATION OF GENES IN OXYGEN AND GLUCOSE DEPRIVED BRAIN IN ASSOCIATION WITH CIRCADIAN RHYTHMS AND HOW THESE CAN BE TARGETED AS NEUROPROTECTIVE AGENTS FOR CNS INJURIES. FINALLY, WE WILL EMPHASIZE ON ALTERNATE BREATHING OR YOGIC INTERVENTIONS TO OVERCOME THE HYPOXIA ASSOCIATED ANOMALIES THAT COULD ULTIMATELY LEAD TO IMPROVEMENT IN CEREBRAL PERFUSION. 2017 2 82 48 A MECHANISTIC MODEL FOR YOGA AS A PREVENTIVE AND THERAPEUTIC MODALITY. YOGA IS AN ANCIENT INDIAN TECHNIQUE OF HEALTHY LIVING. NUMEROUS STUDIES HAVE CORROBORATED YOGA'S BENEFICIAL EFFECTS, INCLUDING A FAVORABLE INFLUENCE ON AUTONOMIC FUNCTION AND NEGATIVE EMOTIONS. EXTENSIVE RESEARCH IN THE LAST FEW DECADES HAS REVEALED THE CRITICAL ROLE THAT YOGA CAN PLAY IN ERADICATING STRESS. THIS HAS LAID TO THE FOUNDATION FOR A SCIENTIFIC UNDERSTANDING OF PATHOPHYSIOLOGICAL CHANGES ATTRIBUTED TO STRESS, PARTICULARLY AT THE MOLECULAR AND GENETIC LEVELS. THIS PRIMARILY HAS HELPED UNDERSTAND THE EPIGENETIC AND GENETIC MECHANISM AT PLAY TO INDUCE AND ALLEVIATE STRESS, PARTICULARLY THOSE RELATED TO EMOTIONAL ABERRATIONS. AS RESEARCH HAS INDICATED, NEGATIVE EMOTIONS ARE TRANSLATED INTO VASCULAR INFLAMMATION APPROPRIATELY ACCENTUATED BY A SYMPATHETIC PREDOMINANT AUTONOMIC FUNCTION. THIS CASCADE IS BOLSTERED BY MULTIPLE FACTORS, INCLUDING ACTIVATION OF "STRESSOR" GENES AND ELABORATING HORMONES, INCLUDING STEROIDS WITH SOMETIMES NOCUOUS CONSEQUENCES, PARTICULARLY WHEN CHRONIC. YOGA HAS BEEN CATEGORICALLY FOUND TO HAVE INHIBITED EACH AND EVERY ONE OF THESE BANEFUL EFFECTS OF STRESS. IN FACT, IT ALSO CHANGES THE NEURONAL CIRCUITS THAT POTENTIATE SUCH A PLETHORA OF PATHOLOGICAL CHANGES. THIS, IN TURN, HAS ACCENTUATED YOGA'S RELEVANCE AS A POWERFUL PREVENTIVE INTERVENTION IN NONCOMMUNICABLE DISEASES (NCD). NCDS, INCLUDING HEART DISEASE, STROKE, AND RHEUMATOLOGICAL DISORDERS, ARE ESSENTIALLY INFLAMMATORY DISEASES THAT PERPETUATE INFLAMMATION IN DIFFERENT BEDS LIKE VASCULAR OR JOINT SPACES. THE PRECISE MECHANISM BY WHICH YOGA INDUCES SUCH BENEFICIAL CHANGES IS YET TO BE DELINEATED. HOWEVER, A CORNUCOPIA OF POINTERS INDICATES THAT NEURAL, ENDOCRINE, IMMUNOLOGICAL, CELLULAR, GENETIC, AND EPIGENETIC MECHANISMS ARE AT PLAY. THIS ARTICLE ATTEMPTS TO COBBLE TOGETHER NEWFANGLED RESEARCH TO DELINEATE A MEDICAL MODEL FOR THIS 5000-YEAR-OLD PRACTICE FROM INDIA. THIS IS IMPERATIVE, AS A MECHANISTIC MODEL OF THIS ANCIENT-BUT-COMPLEX SYSTEM WOULD ENABLE A MORE COMPREHENSIVE UNDERSTANDING OF ITS MECHANISM AND REVEAL ITS YET-UNDISCOVERED POSITIVE HEALTH EFFECTS. 2021 3 1319 26 HEART RATE VARIABILITY, FLOW, MOOD AND MENTAL STRESS DURING YOGA PRACTICES IN YOGA PRACTITIONERS, NON-YOGA PRACTITIONERS AND PEOPLE WITH METABOLIC SYNDROME. HEART RATE VARIABILITY (HRV) AND RESPIRATORY SINUS ARRHYTHMIA ARE DIRECTLY ASSOCIATED WITH AUTONOMIC FLEXIBILITY, SELF-REGULATION AND WELL-BEING, AND INVERSELY ASSOCIATED WITH PHYSIOLOGICAL STRESS, PSYCHOLOGICAL STRESS AND PATHOLOGY. YOGA ENHANCES AUTONOMIC ACTIVITY, MITIGATES STRESS AND BENEFITS STRESS-RELATED CLINICAL CONDITIONS, YET THE RELATIONSHIP BETWEEN AUTONOMIC ACTIVITY AND PSYCHOPHYSIOLOGICAL RESPONSES DURING YOGA PRACTICES AND STRESSFUL STIMULI HAS NOT BEEN WIDELY EXPLORED. THIS EXPERIMENTAL STUDY EXPLORED THE RELATIONSHIP BETWEEN HRV, MOOD STATES AND FLOW EXPERIENCES IN REGULAR YOGA PRACTITIONERS (YP), NON-YOGA PRACTITIONERS (NY) AND PEOPLE WITH METABOLIC SYNDROME (METS), DURING MENTAL ARITHMETIC STRESS TEST (MAST) AND VARIOUS YOGA PRACTICES. THE STUDY FOUND THAT THE MAST PLACED A CARDIO-AUTONOMIC BURDEN IN ALL PARTICIPANTS WITH THE YP GROUP SHOWING THE GREATEST REACTIVITY AND THE MOST RAPID RECOVERY, WHILE THE METS GROUP HAD SIGNIFICANTLY BLUNTED RECOVERY. THE YP GROUP ALSO REPORTED A HEIGHTENED EXPERIENCE OF FLOW AND POSITIVE MOOD STATES COMPARED TO NY AND METS GROUPS AS WELL AS HAVING A HIGHER VAGAL TONE DURING ALL RESTING CONDITIONS. THESE RESULTS SUGGEST YOGA PRACTITIONERS HAVE A GREATER HOMEOSTATIC CAPACITY AND AUTONOMIC, METABOLIC AND PHYSIOLOGICAL RESILIENCE. FURTHER STUDIES ARE NOW NEEDED TO DETERMINE IF REGULAR YOGA PRACTICE MAY IMPROVE AUTONOMIC FLEXIBILITY IN NON-YOGA PRACTITIONERS AND METABOLIC SYNDROME PATIENTS. CLINICAL TRIAL NO 'ACTRN 2614001075673'. 2016 4 1882 34 REDUCING ALLOSTATIC LOAD IN DEPRESSION AND ANXIETY DISORDERS: PHYSICAL ACTIVITY AND YOGA PRACTICE AS ADD-ON THERAPIES. THE ALLOSTATIC LOAD (AL) INDEX CONSTITUTES A USEFUL TOOL TO OBJECTIVELY ASSESS THE BIOLOGICAL ASPECTS OF CHRONIC STRESS IN CLINICAL PRACTICE. AL INDEX HAS BEEN POSITIVELY CORRELATED WITH CUMULATIVE CHRONIC STRESS (PHYSICAL AND PSYCHOSOCIAL STRESSORS) AND WITH A HIGH RISK TO DEVELOP PATHOLOGICAL CONDITIONS (E.G., METABOLIC SYNDROME, CARDIOVASCULAR PATHOLOGY, INFLAMMATORY DISORDERS) AND THE SO-CALLED STRESS-RELATED PSYCHIATRIC DISORDERS, INCLUDING ANXIETY AND DEPRESSIVE DISORDERS. CHRONIC STRESS HAS NEGATIVE EFFECTS ON BRAIN NEUROPLASTICITY, ESPECIALLY ON HIPPOCAMPAL NEUROGENESIS AND THESE EFFECTS MAY BE REVERSED BY ANTIDEPRESSANT TREATMENTS. SEVERAL EVIDENCES INDICATE THAT NON-PHARMACOLOGICAL INTERVENTIONS BASED ON PHYSICAL ACTIVITY AND YOGA PRACTICE MAY ADD SYNERGIZING BENEFITS TO CLASSICAL TREATMENTS (ANTIDEPRESSANT AND BENZODIAZEPINES) FOR DEPRESSION AND ANXIETY, REDUCING THE NEGATIVE EFFECTS OF CHRONIC STRESS. THE AIM OF THIS REVIEW IS TO PROVIDE A GENERAL OVERVIEW OF CURRENT KNOWLEDGE ON AL AND CHRONIC STRESS IN RELATION TO DEPRESSION AND ANXIETY, PHYSICAL ACTIVITY AND YOGA PRACTICE. 2020 5 2886 38 YOGA: BALANCING THE EXCITATION-INHIBITION EQUILIBRIUM IN PSYCHIATRIC DISORDERS. SOCIAL BEHAVIORAL DISTURBANCES ARE CENTRAL TO MOST PSYCHIATRIC DISORDERS. A DISEQUILIBRIUM WITHIN THE CORTICAL EXCITATORY AND INHIBITORY NEUROTRANSMITTER SYSTEMS UNDERLIES THESE DEFICITS. GAMMA-AMINOBUTYRIC ACID (GABA) AND GLUTAMATE ARE THE MOST ABUNDANT EXCITATORY AND INHIBITORY NEUROTRANSMITTERS IN THE BRAIN THAT CONTRIBUTE TO THIS EQUILIBRIUM. SEVERAL CONTEMPORARY THERAPIES USED IN TREATING PSYCHIATRIC DISORDERS, REGULATE THIS GABA-GLUTAMATE BALANCE. YOGA HAS BEEN STUDIED AS AN ADJUVANT TREATMENT ACROSS A BROAD RANGE OF PSYCHIATRIC DISORDERS AND IS SHOWN TO HAVE SHORT-TERM THERAPEUTIC GAINS. EMERGING EVIDENCE FROM RECENT CLINICAL IN VIVO EXPERIMENTS SUGGESTS THAT YOGA IMPROVES GABA-MEDIATED CORTICAL-INHIBITORY TONE AND ENHANCES PERIPHERAL OXYTOCIN LEVELS. THIS IS LIKELY TO HAVE A MORE CONTROLLED DOWNSTREAM RESPONSE OF THE HYPOTHALAMO-PITUITARY-ADRENAL SYSTEM BY MEANS OF REDUCED CORTISOL RELEASE AND HENCE A BLUNTED SYMPATHETIC RESPONSE TO STRESS. ANIMAL AND EARLY FETAL DEVELOPMENTAL STUDIES SUGGEST AN INTER-DEPENDENT ROLE OF OXYTOCIN AND GABA IN REGULATING SOCIAL BEHAVIORS. IN KEEPING WITH THESE OBSERVATIONS, WE PROPOSE AN INTEGRATED NEUROBIOLOGICAL MODEL TO STUDY THE MECHANISMS OF THERAPEUTIC BENEFITS WITH YOGA. APART FROM PROVIDING A NEUROSCIENTIFIC BASIS FOR APPLYING A TRADITIONAL SYSTEM OF PRACTICE IN THE CLINICAL SETTING, THIS MODEL CAN BE USED AS A FRAMEWORK FOR STUDYING YOGA MECHANISMS IN FUTURE CLINICAL TRIALS. 2019 6 1639 41 MODULATION OF IMMUNE RESPONSES IN STRESS BY YOGA. STRESS IS A CONSTANT FACTOR IN TODAY'S FASTPACED LIFE THAT CAN JEOPARDIZE OUR HEALTH IF LEFT UNCHECKED. IT IS ONLY IN THE LAST HALF CENTURY THAT THE ROLE OF STRESS IN EVERY AILMENT FROM THE COMMON COLD TO AIDS HAS BEEN EMPHASIZED, AND THE MECHANISMS INVOLVED IN THIS PROCESS HAVE BEEN STUDIED. STRESS INFLUENCES THE IMMUNE RESPONSE PRESUMABLY THROUGH THE ACTIVATION OF THE HYPOTHALAMIC-PITUITARY ADRENAL AXIS, HYPOTHALAMIC PITUITARY-GONADAL AXIS, AND THE SYMPATHETIC-ADRENAL-MEDULLARY SYSTEM. VARIOUS NEUROTRANSMITTERS, NEUROPEPTIDES, HORMONES, AND CYTOKINES MEDIATE THESE COMPLEX BIDIRECTIONAL INTERACTIONS BETWEEN THE CENTRAL NERVOUS SYSTEM (CNS) AND THE IMMUNE SYSTEM. THE EFFECTS OF STRESS ON THE IMMUNE RESPONSES RESULT IN ALTERATIONS IN THE NUMBER OF IMMUNE CELLS AND CYTOKINE DYSREGULATION. VARIOUS STRESS MANAGEMENT STRATEGIES SUCH AS MEDITATION, YOGA, HYPNOSIS, AND MUSCLE RELAXATION HAVE BEEN SHOWN TO REDUCE THE PSYCHOLOGICAL AND PHYSIOLOGICAL EFFECTS OF STRESS IN CANCERS AND HIV INFECTION. THIS REVIEW AIMS TO DISCUSS THE EFFECT OF STRESS ON THE IMMUNE SYSTEM AND EXAMINE HOW RELAXATION TECHNIQUES SUCH AS YOGA AND MEDITATION COULD REGULATE THE CYTOKINE LEVELS AND HENCE, THE IMMUNE RESPONSES DURING STRESS. 2008 7 1089 36 EFFECTS OF YOGA ON THE AUTONOMIC NERVOUS SYSTEM, GAMMA-AMINOBUTYRIC-ACID, AND ALLOSTASIS IN EPILEPSY, DEPRESSION, AND POST-TRAUMATIC STRESS DISORDER. A THEORY IS PROPOSED TO EXPLAIN THE BENEFITS OF YOGA PRACTICES IN DIVERSE, FREQUENTLY COMORBID MEDICAL CONDITIONS BASED ON THE CONCEPT THAT YOGA PRACTICES REDUCE ALLOSTATIC LOAD IN STRESS RESPONSE SYSTEMS SUCH THAT OPTIMAL HOMEOSTASIS IS RESTORED. IT IS HYPOTHESIZED THAT STRESS INDUCES (1) IMBALANCE OF THE AUTONOMIC NERVOUS SYSTEM (ANS) WITH DECREASED PARASYMPATHETIC NERVOUS SYSTEM (PNS) AND INCREASED SYMPATHETIC NERVOUS SYSTEM (SNS) ACTIVITY, (2) UNDERACTIVITY OF THE GAMMA AMINO-BUTYRIC ACID (GABA) SYSTEM, THE PRIMARY INHIBITORY NEUROTRANSMITTER SYSTEM, AND (3) INCREASED ALLOSTATIC LOAD. IT IS FURTHER HYPOTHESIZED THAT YOGA-BASED PRACTICES (4) CORRECT UNDERACTIVITY OF THE PNS AND GABA SYSTEMS IN PART THROUGH STIMULATION OF THE VAGUS NERVES, THE MAIN PERIPHERAL PATHWAY OF THE PNS, AND (5) REDUCE ALLOSTATIC LOAD. DEPRESSION, EPILEPSY, POST TRAUMATIC STRESS DISORDER (PTSD), AND CHRONIC PAIN EXEMPLIFY MEDICAL CONDITIONS THAT ARE EXACERBATED BY STRESS, HAVE LOW HEART RATE VARIABILITY (HRV) AND LOW GABAERGIC ACTIVITY, RESPOND TO PHARMACOLOGIC AGENTS THAT INCREASE ACTIVITY OF THE GABA SYSTEM, AND SHOW SYMPTOM IMPROVEMENT IN RESPONSE TO YOGA-BASED INTERVENTIONS. THE OBSERVATION THAT TREATMENT RESISTANT CASES OF EPILEPSY AND DEPRESSION RESPOND TO VAGAL NERVE STIMULATION CORROBORATES THE NEED TO CORRECT PNS UNDERACTIVITY AS PART OF A SUCCESSFUL TREATMENT PLAN IN SOME CASES. ACCORDING TO THE PROPOSED THEORY, THE DECREASED PNS AND GABAERGIC ACTIVITY THAT UNDERLIES STRESS-RELATED DISORDERS CAN BE CORRECTED BY YOGA PRACTICES RESULTING IN AMELIORATION OF DISEASE SYMPTOMS. THIS HAS FAR-REACHING IMPLICATIONS FOR THE INTEGRATION OF YOGA-BASED PRACTICES IN THE TREATMENT OF A BROAD ARRAY OF DISORDERS EXACERBATED BY STRESS. 2012 8 1335 33 HOW DOES YOGA PRACTICE AND THERAPY YIELD PSYCHOLOGICAL BENEFITS? A REVIEW AND MODEL OF TRANSDIAGNOSTIC PROCESSES. INTEREST IN YOGA AS AN INTERVENTION FOR PSYCHOLOGICAL WELLBEING HAS INCREASED IN RECENT YEARS, WITH LITERATURE INVESTIGATING BENEFICIAL EFFECTS IN A VARIETY OF PRESENTATIONS AND SETTINGS. THE THEORETICAL UNDERSTANDING OF THIS BENEFIT HAS PREVIOUSLY FOCUSED ON PHYSIOLOGICAL CHANGES INVOLVED IN YOGA PRACTICE, HOWEVER INTEREST HAS TURNED TO THE POTENTIAL PSYCHOLOGICAL MECHANISMS ELICITING PSYCHOLOGICAL WELLBEING. THE CURRENT PAPER BUILDS ON PREVIOUS THEORY AND ARGUES THAT YOGA PRACTICE TARGETS TRANSDIAGNOSTIC PSYCHOLOGICAL PROCESSES; MECHANISMS THAT FEATURE COMMONLY ACROSS A WIDE RANGE OF PRESENTATIONS, THUS REDUCING DISTRESS AND INCREASING WELLBEING ACROSS CLINICAL AND NON-CLINICAL POPULATIONS. FEATURES OF YOGA PRACTICE ARE DISCUSSED IN RELATION TO THESE TRANSDIAGNOSTIC PROCESSES AND THE FEATURES OF MODERN TALKING THERAPIES. A NEW MODEL IS PROPOSED POSITING SPECIFIC ASPECTS OF YOGA PRACTICE CORRELATE WITH SPECIFIC TRANSDIAGNOSTIC PROCESSES TO ELICIT PSYCHOLOGICAL CHANGE AND ARGUES THAT THE MECHANISMS BY WHICH CHANGE OCCURS ARE DIRECTLY COMPARED WITH THE CHANGES OBSERVED IN TALKING THERAPIES. THE IMPLICATIONS FOR FUTURE RESEARCH AND THE POTENTIAL FOR THIS TO SUPPORT THE COMMISSIONING OF HOLISTIC APPROACHES IN CLINICAL PRACTICE ARE DISCUSSED. 2022 9 1590 24 MEDITATION AND YOGA CAN MODULATE BRAIN MECHANISMS THAT AFFECT BEHAVIOR AND ANXIETY-A MODERN SCIENTIFIC PERSPECTIVE. MEDITATION AND YOGA TECHNIQUES ARE RECEIVING INCREASED ATTENTION THROUGHOUT THE WORLD, DUE TO THE ACCUMULATION OF EVIDENCE BASED RESEARCH THAT PROVES THE DIRECT AND INDIRECT BENEFITS OF SUCH PRACTICES. BASED ON STUDIES CONDUCTED SO FAR, IT HAS BEEN FOUND THAT THE PRACTICE OF MEDITATION TRIGGERS NEUROTRANSMITTERS THAT MODULATE PSYCHOLOGICAL DISORDERS SUCH AS ANXIETY. THIS PAPER WILL REVIEW THE PSYCHOLOGICAL EFFECTS OF THE PRACTICE OF MEDITATION, THE ROLE OF NEUROTRANSMITTERS, AND STUDIES USING EEG AND FMRI. 2015 10 311 31 AN EXPLORATIVE STUDY OF METABOLIC RESPONSES TO MENTAL STRESS AND YOGA PRACTICES IN YOGA PRACTITIONERS, NON-YOGA PRACTITIONERS AND INDIVIDUALS WITH METABOLIC SYNDROME. BACKGROUND: STRESS PLACES A METABOLIC BURDEN ON HOMEOSTASIS AND IS LINKED TO HEIGHTENED SYMPATHETIC ACTIVITY, INCREASED ENERGY EXPENDITURE AND PATHOLOGY. THE YOGIC STATE IS A HYPOMETABOLIC STATE THAT CORRESPONDS WITH MIND-BODY COHERENCE AND REDUCED STRESS. THIS STUDY AIMED TO INVESTIGATE METABOLIC RESPONSES TO STRESS AND DIFFERENT YOGA PRACTICES IN REGULAR YOGA PRACTITIONERS (YP), NON-YOGA PRACTITIONERS (NY) AND METABOLIC SYNDROME PATIENTS (MS). METHODS: YP (N = 16), NY (N = 15) AND MS (N = 15) SUBJECTS UNDERWENT AN EXPERIMENTAL PROTOCOL THAT COMPRISED OF DIFFERENT 5-MINUTE INTERVENTIONS INCLUDING MENTAL ARITHMETIC STRESS TEST (MAST), ALTERNATE NOSTRIL BREATHING (ANB), KAPABHATI BREATHING (KB) AND MEDITATION (MED) INTERSPERSED WITH 5 MINUTES OF QUIET RESTING (NEUTRAL CONDITION (NC)). DURING THE INTERVENTION PERIODS CONTINUOUS BODY WEIGHT ADJUSTED OXYGEN CONSUMPTION (VO2ML/MIN/KG) WAS MEASURED USING OPEN CIRCUIT INDIRECT CALORIMETRY WITH A CANOPY HOOD. RESULTS: THIS IS THE FIRST STUDY TO REPORT OXYGEN CONSUMPTION (OC) IN YOGA PRACTITIONERS DURING AND AFTER MAST AND THE FIRST TO REPORT BOTH WITHIN AND BETWEEN DIFFERENT POPULATIONS. THE RESULTS WERE ANALYSED WITH SPSS 16 USING 3X9 MIXED FACTORIAL ANOVAS. THE SINGLE BETWEEN-SUBJECT FACTOR WAS GROUP (YP, NY AND MS), THE SINGLE WITHIN-SUBJECT FACTOR WAS MADE UP OF THE NINE INTERVENTION PHASES (NC1, MAST, NC2, ANB, NC3, KB, NC4, MED, NC5). THE RESULTS DEMONSTRATED THAT THE REGULAR YP GROUP HAD SIGNIFICANTLY LESS OC AND GREATER VARIABILITY IN THEIR OC ACROSS ALL PHASES COMPARED TO THE MS GROUP (P = .003) AND NY GROUP (P = .01). ALL GROUPS SIGNIFICANTLY RAISED THEIR OC DURING THE MENTAL ARITHMETIC STRESS, HOWEVER THE MS GROUP HAD A SIGNIFICANTLY BLUNTED POST-STRESS RECOVERY WHEREAS THE YP GROUP RAPIDLY RECOVERED BACK TO BASELINE LEVELS WITH POST STRESS RECOVERY BEING GREATER THAN EITHER THE NY GROUP OR MS GROUP. CONCLUSIONS: YOGA PRACTITIONERS HAVE GREATER METABOLIC VARIABILITY COMPARED TO NON-YOGA PRACTITIONERS AND METABOLIC SYNDROME PATIENTS WITH REDUCED OXYGEN REQUIREMENTS DURING RESTING CONDITIONS AND MORE RAPID POST-STRESS RECOVERY. OC IN METABOLIC SYNDROME PATIENTS DISPLAYS SIGNIFICANTLY BLUNTED POST-STRESS RECOVERY DEMONSTRATING REDUCED METABOLIC RESILIENCE. OUR RESULTS SUPPORT THE FINDINGS OF PREVIOUS RANDOMISED TRIALS THAT SUGGEST REGULAR YOGA PRACTICE MAY MITIGATE AGAINST THE EFFECTS OF METABOLIC SYNDROME. CLINICAL TRIAL NUMBER: ACTRN12614001075673; DATE OF REGISTRATION: 07/10/2014. 2014 11 1887 27 REFLECTIONS ON CLINICAL APPLICATIONS OF YOGA IN VOICE THERAPY WITH MTD. THIS PAPER EXPLORES THE APPLICATION OF MODIFIED YOGA TECHNIQUES, AS AN ADJUNCT TO VOICE THERAPY, BY A SPEECH PATHOLOGIST WHO IS ALSO A YOGA TEACHER. YOGA PRACTICES, WITH EFFECTS THAT MAY BE SHORT-TERM, ARE NOT CONSIDERED A SUBSTITUTE FOR COMPREHENSIVE AND INTEGRATED SOMATIC RETRAINING SYSTEMS (SUCH AS THE ALEXANDER TECHNIQUE OR FELDENKRAIS ATM). HOWEVER, WHEN YOGA IS CONDUCTED EMPHASIZING KINAESTHETIC AND PROPRIOCEPTIVE AWARENESS, THE CLIENT MAY ACHIEVE AN 'AWARENESS STATE' THAT FACILITATES THE LEARNING OF VOCAL REMEDIATION TECHNIQUES (FOR EXAMPLE, BY MORE EASILY 'TUNING IN' TO THE SUBTLE SENSATIONS OF SUPRALARYNGEAL DECONSTRICTION). CORE YOGA ELEMENTS AND CLINICAL APPLICATIONS ARE IDENTIFIED. THE POTENTIAL BENEFITS AND CONSIDERATIONS WHEN USING YOGA AS AN ADJUNCT TO THE TREATMENT OF MUSCLE TENSION DYSPHONIA (MTD) ARE EXPLORED. 2012 12 2776 30 YOGA SCHOOL OF THOUGHT AND PSYCHIATRY: THERAPEUTIC POTENTIAL. YOGA IS A TRADITIONAL LIFE-STYLE PRACTICE USED FOR SPIRITUAL REASONS. HOWEVER, THE PHYSICAL COMPONENTS LIKE THE ASANAS AND PRANAYAAMAS HAVE DEMONSTRATED PHYSIOLOGICAL AND THERAPEUTIC EFFECTS. THERE IS EVIDENCE FOR YOGA AS BEING A POTENT ANTIDEPRESSANT THAT MATCHES WITH DRUGS. IN DEPRESSIVE DISORDER, YOGA 'CORRECTS' AN UNDERLYING COGNITIVE PHYSIOLOGY. IN SCHIZOPHRENIA PATIENTS, YOGA HAS BENEFITS AS AN ADD-ON INTERVENTION IN PHARMACOLOGICALLY STABILIZED SUBJECTS. THE EFFECTS ARE PARTICULARLY NOTABLE ON NEGATIVE SYMPTOMS. YOGA ALSO HELPS TO CORRECT SOCIAL COGNITION. YOGA CAN BE INTRODUCED EARLY IN THE TREATMENT OF PSYCHOSIS WITH SOME BENEFITS. ELEVATION OF OXYTOCIN MAY BE A MECHANISM OF YOGA EFFECTS IN SCHIZOPHRENIA. CERTAIN COMPONENTS OF YOGA HAVE DEMONSTRATED NEUROBIOLOGICAL EFFECTS SIMILAR TO THOSE OF VAGAL STIMULATION, INDICATING THIS (INDIRECT OR AUTOGENOUS VAGAL STIMULATION) AS A POSSIBLE MECHANISM OF ITS ACTION. IT IS TIME, PSYCHIATRISTS EXPLOITED THE BENEFITS IF YOGA FOR A COMPREHENSIVE CARE IN THEIR PATIENTS. 2013 13 1191 28 EVOLUTION FROM FOUR MENTAL STATES TO THE HIGHEST STATE OF CONSCIOUSNESS: A NEUROPHYSIOLOGICAL BASIS OF MEDITATION AS DEFINED IN YOGA TEXTS. THIS CHAPTER PROVIDES A THEORETICAL INTRODUCTION TO STATES OF CONSCIOUSNESS AND REVIEWS NEUROSCIENTIFIC INVESTIGATIONS OF MEDITATION. THE DIFFERENT STATES OF CONSCIOUSNESS CONSIST OF FOUR MENTAL STATES, I.E., CANCALATA (RANDOM THINKING), EKAGRATA (NON-MEDITATIVE FOCUSING), DHARNA (FOCUSED MEDITATION), AND DHYANA (MEDITATION) AS DEFINED IN YOGA TEXTS. MEDITATION IS A SELF-REGULATED MENTAL PROCESS ASSOCIATED WITH DEEP RELAXATION AND INCREASED INTERNALIZED ATTENTION. SCIENTIFIC INVESTIGATIONS ON MEDITATION REPORTED CHANGES IN ELECTROPHYSIOLOGICAL SIGNALS AND NEUROIMAGING MEASURES. BUT MOST OUTCOMES OF MEDITATION STUDIES SHOWED INCONSISTENT RESULTS, THIS MAY BE DUE TO HETEROGENEITY IN MEDITATION METHODS AND TECHNIQUES EVOLVED IN THE LAST 200 YEARS. TRADITIONALLY, THE FEATURES OF MEDITATION INCLUDE THE CAPACITY TO SUSTAIN A HEIGHTENED AWARENESS OF THOUGHTS, BEHAVIORS, EMOTIONS, AND PERCEPTIONS. GENERALLY, MEDITATION INVOLVES NON-REACTIVE EFFORTLESS MONITORING OF THE CONTENT OF EXPERIENCE FROM MOMENT TO MOMENT. FOCUSED MEDITATION PRACTICE INVOLVES AWARENESS ON A SINGLE OBJECT AND OPEN MONITORING MEDITATION IS A NON-DIRECTIVE MEDITATION INVOLVED ATTENTION IN BREATHING, MANTRA, OR SOUND. THEREFORE, RESULTS OF FEW EMPIRICAL STUDIES OF ADVANCED MEDITATORS OR BEGINNERS REMAIN TENTATIVE. THIS IS AN ATTEMPT TO COMPILE THE MEDITATION-RELATED CHANGES IN ELECTROPHYSIOLOGICAL AND NEUROIMAGING PROCESSES AMONG EXPERIENCED AND NOVICE PRACTITIONERS. 2019 14 1772 34 POTENTIAL SELF-REGULATORY MECHANISMS OF YOGA FOR PSYCHOLOGICAL HEALTH. RESEARCH SUGGESTING THE BENEFICIAL EFFECTS OF YOGA ON MYRIAD ASPECTS OF PSYCHOLOGICAL HEALTH HAS PROLIFERATED IN RECENT YEARS, YET THERE IS CURRENTLY NO OVERARCHING FRAMEWORK BY WHICH TO UNDERSTAND YOGA'S POTENTIAL BENEFICIAL EFFECTS. HERE WE PROVIDE A THEORETICAL FRAMEWORK AND SYSTEMS-BASED NETWORK MODEL OF YOGA THAT FOCUSES ON INTEGRATION OF TOP-DOWN AND BOTTOM-UP FORMS OF SELF-REGULATION. WE BEGIN BY CONTEXTUALIZING YOGA IN HISTORICAL AND CONTEMPORARY SETTINGS, AND THEN DETAIL HOW SPECIFIC COMPONENTS OF YOGA PRACTICE MAY AFFECT COGNITIVE, EMOTIONAL, BEHAVIORAL, AND AUTONOMIC OUTPUT UNDER STRESS THROUGH AN EMPHASIS ON INTEROCEPTION AND BOTTOM-UP INPUT, RESULTING IN PHYSICAL AND PSYCHOLOGICAL HEALTH. THE MODEL DESCRIBES YOGA PRACTICE AS A COMPREHENSIVE SKILLSET OF SYNERGISTIC PROCESS TOOLS THAT FACILITATE BIDIRECTIONAL FEEDBACK AND INTEGRATION BETWEEN HIGH- AND LOW-LEVEL BRAIN NETWORKS, AND AFFERENT AND RE-AFFERENT INPUT FROM INTEROCEPTIVE PROCESSES (SOMATOSENSORY, VISCEROSENSORY, CHEMOSENSORY). FROM A PREDICTIVE CODING PERSPECTIVE WE PROPOSE A SHIFT TO PERCEPTUAL INFERENCE FOR STRESS MODULATION AND OPTIMAL SELF-REGULATION. WE DESCRIBE HOW THE PROCESSES THAT SUB-SERVE SELF-REGULATION BECOME MORE AUTOMATIZED AND EFFICIENT OVER TIME AND PRACTICE, REQUIRING LESS EFFORT TO INITIATE WHEN NECESSARY AND TERMINATE MORE RAPIDLY WHEN NO LONGER NEEDED. TO SUPPORT OUR PROPOSED MODEL, WE PRESENT THE AVAILABLE EVIDENCE FOR YOGA AFFECTING SELF-REGULATORY PATHWAYS, INTEGRATING EXISTING CONSTRUCTS FROM BEHAVIOR THEORY AND COGNITIVE NEUROSCIENCE WITH EMERGING YOGA AND MEDITATION RESEARCH. THIS PAPER IS INTENDED TO GUIDE FUTURE BASIC AND CLINICAL RESEARCH, SPECIFICALLY TARGETING AREAS OF DEVELOPMENT IN THE TREATMENT OF STRESS-MEDIATED PSYCHOLOGICAL DISORDERS. 2014 15 653 18 EATING DISORDERS, EMBODIMENT, AND YOGA: A CONCEPTUAL OVERVIEW. YOGA AND ITS RELATION TO EMBODIMENT AND DISORDERED EATING HAS ONLY RECENTLY RECEIVED RESEARCH ATTENTION. NEVERTHELESS, EARLY RESEARCH INDICATES THAT YOGA IS AN EFFECTIVE TOOL IN THE PREVENTION AND TREATMENT OF EATING DISORDERS. IT IS ASSUMED THAT YOGA AMELIORATES EATING DISORDER SYMPTOMS AND FACILITATES A SHIFT FROM NEGATIVE TOWARDS POSITIVE BODY IMAGE AND WELL-BEING BY CULTIVATING POSITIVE EMBODIMENT (I.E., THE ABILITY TO FEEL A SENSE OF CONNECTION BETWEEN MIND AND BODY). IN ORDER TO PROVIDE THE CONTEXT OF THE CONSTRUCTS OF DISORDERED EATING, EMBODIMENT, AND YOGA, THIS ARTICLE PRESENTS A BRIEF OVERVIEW AND CONCEPTUALIZATION OF THESE CONSTRUCTS. THE THREE MAJOR EATING DISORDERS AND CURRENT TREATMENT METHODS ARE DESCRIBED. FURTHER, THE PHILOSOPHICAL ROOTS AND THEORETICAL MODELS OF EMBODIMENT ARE DELINEATED AND THEIR COMMUNAL CORE FEATURES ARE OUTLINED. LASTLY, THE ORIGIN, BASIC PRINCIPLES, AND MODERN INTERPRETATIONS OF YOGA ARE DISCUSSED. 2020 16 2908 20 [PHYSICAL EXERCISE AND YOGA IN PREVENTION AND TREATMENT OF ADDICTIVE DISEASES]. PREVENTION OF ADDICTIVE DISEASES SHOULD BE COMPLEX AND SYSTEMATIC AND IT SHOULD INCLUDE TRAINING OF SOCIAL SKILLS, DECISION-MAKING SKILLS, FAMILY INTERVENTION, ETC. SIMILARLY, EFFECTIVE TREATMENT IS USUALLY LONG-TERM, SYSTEMATIC AND COMPLEX. PHYSICAL EXERCISE AND YOGA CAN BE USEFUL COMPONENTS OF COMPREHENSIVE PREVENTION AND TREATMENT PROGRAMMES. ON THE OTHER HAND, COMPETITIVE PROFESSIONAL SPORT RATHER INCREASES THE NUMBER OF RISK FACTORS FOR SUBSTANCE-RELATED PROBLEMS. PRACTICAL EXPERIENCE WITH THE USE OF YOGA IN SUBSTANCE DEPENDENT PATIENTS AND PATHOLOGICAL GAMBLES ARE MENTIONED. ONE OF THE ADVANTAGES OF YOGA IS THE INTEGRATION OF PHYSICAL EXERCISE AND RELAXATION. 2005 17 1951 23 SCIENCE OF THE MIND: ANCIENT YOGA TEXTS AND MODERN STUDIES. THE PRACTICE OF YOGA IS GAINING IN POPULARITY WITH A WIDE RANGE OF PRACTICES. RECENT RESEARCH AND DESCRIPTIONS FROM THE ANCIENT TEXTS ARE OFTEN CONCURRENT WITH REGARD TO THE EFFECTS OF THE PRACTICE, TAKING INTO ACCOUNT EXPECTED DIFFERENCES BETWEEN MODERN SCIENTIFIC TERMS AND THOSE USED IN THE ORIGINAL TEXTS. VOLUNTARILY REGULATED YOGA BREATHING PRACTICES FORM A BRIDGE BETWEEN PHYSICAL AND MENTAL CHANGES. THE VOLUNTARILY REGULATED YOGA BREATHING HAS DISTINCT EFFECTS ON METABOLISM, THE AUTONOMIC NERVOUS SYSTEM, HIGHER BRAIN FUNCTIONS, AND MENTAL STATE. THE EFFECTS OF MEDITATION ON THE NERVOUS SYSTEM AND MENTAL STATE ARE EVEN CLEARER. 2013 18 924 19 EFFECTIVENESS OF YOGA IN EATING DISORDERS - A CASE REPORT. EATING DISORDERS ARE AMONG THE MOST COMMON PSYCHOSOMATIC DISEASES AND ARE OFTEN ASSOCIATED WITH NEGATIVE HEALTH CONSEQUENCES. THE USE OF YOGA AS A TREATMENT METHOD IN EATING DISORDERS IS CONTROVERSIAL DISCUSSED. THE INTERVIEWEE WAS A 38 YEAR OLD FEMALE PATIENT SUFFERING ON ANOREXIA NERVOSA AND VARIOUS PSYCHOSOMATIC-PSYCHIATRIC DIAGNOSES IN HER MEDICAL HISTORY. THE PATIENT REPORTED THAT YOGA RECOVERED THE SOUL CONTACT WHICH SHE LOST AND SHE HAD LEARNED TO PERCEIVE AND FEEL HERSELF AGAIN. SHE STATED THAT YOGA HELPED HER TO FIND ACCESS TO HER BODY AND ITS NEEDS AND TO COPE WITH HER TRAUMATIC EXPERIENCES. SHE ALSO REPORTED THAT ATTITUDES HAVE CHANGED IN RELATION TO HER STOMACH IN THE TREATMENT OF HER ANOREXIA. THE CASE REPORT CONFIRMED THE POSITIVE EFFECT OF YOGA ON EATING DISORDERS. RESEARCH SHOULD PAY PARTICULAR ATTENTION TO TAKING INTO ACCOUNT THE INFLUENCE OF INDIVIDUAL'S CO-MORBIDITIES, AS EATING DISORDERS USUALLY OCCUR IN ASSOCIATION WITH CO-MORBIDITIES. 2019 19 2668 33 YOGA IN MAJOR DEPRESSIVE DISORDER: MOLECULAR MECHANISMS AND CLINICAL UTILITY. MAJOR DEPRESSIVE DISORDER (MDD) IS A MIND-BODY DISORDER. CELLULAR AGING HAS BEEN IMPLICATED IN THE PATHOGENESIS OF MDD WITH THE ALTERED MIND-BODY COMMUNICATION MARKERS LIKE STRESS RESPONSE, IMMUNE RESPONSE, NUTRITION SENSING, AND A RANGE OF OTHER REGULATORY FEEDBACK SYSTEMS. IN THIS AGE OF SUPER SPECIALIZATIONS, ONE SPECIFIC TARGET AND INTERVENTIONS (PREFERABLY A DRUG) ON IT ARE BEING RIGOROUSLY SOUGHT BY THE HEALTH CARE COMMUNITY AND INDUSTRY, BUT HAVE FAILED IN IT IN THE LAST FIFTY YEARS IN SPITE OF ADVANCES IN TECHNOLOGY. SINCE, DEPRESSION IS A COMPLEX DISORDER ASSOCIATED WITH INCREASED INCIDENCE OF OTHER COMPLEX DISORDERS, IT MUST BE TREATED BY AN INTEGRATED HOLISTIC APPROACH THAT CAN ADDRESS THE COMPLEXITY OF MDD. INTERVENTIONS TARGETING ACCELERATED BIOLOGICAL AGING TO INCREASE CELLULAR HEALTH IN WHOLE BODY HAVE POTENTIAL TO MANAGE COMPLEX CONDITIONS LIKE MDD AND ITS OVERLAPPING SYMPTOMS AND COMORBIDITIES. YOGA HAS THE POTENTIAL TO BE THE NEXUS BETWEEN, CLINICAL MANAGEMENT OF MDD AND OTHER LIFESTYLE DISEASES. 2021 20 2841 33 YOGA, BIOENERGETICS AND EATING BEHAVIORS: A CONCEPTUAL REVIEW. YOGA IS AN ANCIENT ORIENTAL DISCIPLINE THAT EMERGED FROM MYSTICAL AND PHILOSOPHICAL CONCEPTS. TODAY IT IS PRACTICED IN THE WEST, PARTLY DUE TO THE PROMOTION OF ITS BENEFITS TO IMPROVE THE LIFESTYLE AND OVERALL HEALTH. AS COMPARED TO NON-HATHA YOGA (HY) PRACTITIONERS, HEALTHIER AND BETTER-EATING PATTERNS HAVE BEEN OBSERVED IN THOSE WHO PRACTICE IT. AGREEMENT WITH THE BROUGHT BENEFITS, HY CAN BE USED AS A THERAPEUTIC METHOD TO CORRECT ABNORMAL EATING BEHAVIORS (AEB), OBESITY, AND SOME METABOLIC DISEASES. HOWEVER, THE ENERGY EXPENDITURE DURING TRADITIONAL PROTOCOLS OF HY IS NOT HIGH; HENCE, IT IS NOT VERY EFFECTIVE FOR REDUCING OR MAINTAINING BODY WEIGHT OR TO IMPROVE CARDIOVASCULAR CONDITIONING. EVEN SO, SEVERAL OBSERVATIONAL STUDIES SUGGEST SIGNIFICANT CHANGES IN EATING BEHAVIORS, LIKE A REDUCTION IN DIETARY FAT INTAKE AND INCREMENTS IN THAT OF FRESH VEGETABLES, WHOLE GRAINS AND SOY-BASED PRODUCTS, WHICH IN TURN MAY REDUCE THE RISK FOR CARDIOVASCULAR DISEASES. GIVEN THE INCONSISTENCY OF THE RESULTS DERIVED FROM CROSS-SECTIONAL STUDIES, MORE CASE-CONTROL STUDIES ARE NEEDED TO DEMONSTRATE THE EFFICACY OF HY AS AN ALTERNATIVE METHOD IN THE CLINICAL TREATMENT OF DISORDERED EATING AND METABOLIC DISEASES. 2015