1 906 154 EFFECTIVENESS OF APP-BASED YOGA OF IMMORTALS (YOI) INTERVENTION FOR INSOMNIA IN ASIAN POPULATION DURING PANDEMIC RESTRICTIONS. THE CORONAVIRUS DISEASE 2019 (COVID-19) PANDEMIC CREATED SIGNIFICANT PSYCHOLOGICAL CHALLENGES WORLDWIDE, INCLUDING STRESS, EMOTIONAL DISTRESS, AND INSOMNIA. IN ADDITION, SOCIAL DISTANCING, TRAVEL RESTRICTIONS, AND SPREAD OF DISEASE HAVE RESULTED IN UNIQUE CHALLENGES, CREATING BARRIERS TO HEALTHCARE ACCESS. COMPARED TO THE RATE PRIOR TO THE COVID-19 PANDEMIC, A SIGNIFICANT INCREASE IN CLINICAL INSOMNIA RATES HAVE BEEN REPORTED. WITH WELL-KNOWN LIMITATIONS OF CURRENTLY ESTABLISHED TREATMENTS (E.G., COGNITIVE BEHAVIORAL THERAPY-INSOMNIA (CBT-I), PHARMACOTHERAPY), THERE IS A NEED TO EXPLORE OTHER EFFECTIVE AND SAFE TREATMENT MODALITIES TO TREAT INSOMNIA, ESPECIALLY THOSE THAT CAN BE USED REMOTELY. THE PURPOSE OF THIS STUDY IS TO ASSESS THE EFFECTIVENESS OF APP-BASED INTERVENTION TO TREAT INSOMNIA IN THE CURRENT ERA OF THE COVID-19 PANDEMIC (USING THE YOGA OF IMMORTALS (YOI) APP). THIS PROSPECTIVE COHORT STUDY WAS APPROVED BY THE INSTITUTIONAL REVIEW BOARD. ALL PARTICIPANTS IN THIS STUDY WERE ASKED TO COMPLETE AN ONLINE SURVEY INCLUDING DEMOGRAPHIC DATA AND VALIDATED INSOMNIA SEVERITY INDEX (ISI) AT BASELINE (15 MAY 2020), 4 WEEKS, AND 8 WEEKS AFTER STARTING THE YOI INTERVENTION. SURVEY DATA WAS EXPORTED USING MICROSOFT EXCEL. STATISTICAL ANALYSIS WAS DONE USING THE GRAPHPAD PRISM 8. YOI INTERVENTION SIGNIFICANTLY IMPROVED THE MEAN ISI SCORES IN ALL CATEGORIES OF INSOMNIA (SEVERE, MODERATE, AND SUBTHRESHOLD) AT EACH FOLLOW-UP (P /= 18) WITH A CLINICAL DIAGNOSIS OF IDIOPATHIC PARKINSON'S DISEASE (HOEHN AND YAHR STAGE I TO III) WHO WERE ABLE TO STAND UNAIDED AND WALK WITH OR WITHOUT AN ASSISTIVE DEVICE WERE ENROLLED VIA CONVENIENCE SAMPLING. INTERVENTION: HOME-BASED MINDFULNESS YOGA TRAINING WERE DELIVERED VIA VIDEO-CONFERENCING SOFTWARE (ZOOM) IN EIGHT BI-WEEKLY 90-MIN SESSIONS. MAIN OUTCOMES AND MEASURES: THIS CURRENT STUDY MEASURED FUNCTIONAL BALANCE, MOTOR SYMPTOMS, PERCEIVED BALANCE CONFIDENCE, PERCEIVED FREEZING OF GAIT SYMPTOMS, ANXIETY AND DEPRESSION, MINDFULNESS AND HRQOL USING A TELE-ASSESSMENT APPROACH AT BASELINE AND 1-WEEK POST-INTERVENTION. ALL PARTICIPANTS WERE INVITED TO ATTEND QUALITATIVE INDIVIDUAL INTERVIEWS TO EXPLORE THEIR EXPERIENCE OF USING ONLINE MINDFULNESS YOGA PROGRAM AS A LIFESTYLE INTERVENTION FOR PD REHABILITATION. RESULTS: AMONG THE TEN PATIENTS, 80% COMPLETED THE PROGRAM WITH AN ADHERENCE RATE OF 98.4%. ALL PARTICIPANTS WERE ABLE TO LEARN AND PRACTICE MINDFULNESS YOGA FOLLOWING THE EIGHT BI-WEEKLY ONLINE MINDFULNESS YOGA TRAINING SESSIONS, WITHOUT ANY SIGNIFICANT ADVERSE EVENTS. TELE-ASSESSMENT OF OUTCOMES WERE FEASIBLE AND UNEVENTFUL. QUALITATIVE FEEDBACK REVEALED PARTICIPANTS HAD A HIGH PREFERENCE OF USING THE TELE-REHABILITATION APPROACH TO STAY MINDFUL AND BEING ACTIVE, BOTH PHYSICALLY AND SOCIALLY, WHILE CONFRONTING THE CHANGES BROUGHT BY COVID-19 PANDEMIC. CONCLUSIONS AND RELEVANCE: THE MHEALTH-DELIVERED HOME-BASED MINDFULNESS YOGA INTERVENTION WAS FEASIBLE, SAFE, AND WELL-ACCEPTED AMONG PEOPLE WITH PD TO RELIEVE THE BURDEN BROUGHT BY COVID-19 PANDEMIC. FUTURE STUDIES SHOULD ADOPT A DESIGN WITH ENHANCED RIGOR, A COMPARISON GROUP, AND ENLARGED SAMPLE SIZE TO EVALUATE THE EFFICACY OF THE PROGRAM IN PATIENTS WITH LONG-TERM NEUROLOGICAL CONDITIONS AND/OR PHYSICAL IMPAIRMENTS. WE RECOMMEND A LONGER INTERVENTION DURATION OF AT LEAST 8 WEEKS TO ENHANCE THE PSYCHOPHYSIOLOGICAL EFFECTS. 2022