1 791 135 EFFECT OF YOGA EXERCISE THERAPY ON OXIDATIVE STRESS INDICATORS WITH END-STAGE RENAL DISEASE ON HEMODIALYSIS. BACKGROUND: OXIDATIVE STRESS PROMOTES ENDOTHELIAL DYSFUNCTION AND ATHEROSCLEROSIS IN CHRONIC RENAL DISEASE. OBJECTIVES: THIS STUDY INVESTIGATED THE IMPACT OF HATHA YOGA ON OXIDATIVE STRESS INDICATORS AND OXIDANT STATUS, IN PATIENTS WITH END-STAGE RENAL DISEASE (ESRD) ON HEMODIALYSIS. DESIGN: THIS PROSPECTIVE RANDOMIZED STUDY CONSISTED OF 33 ESRD PATIENTS IN THE HATHA YOGA EXERCISE GROUP WHO WERE MATCHED WITH 35 ESRD PATIENTS IN THE CONTROL GROUP. OUTCOME MEASURES: THE OXIDATIVE STRESS INDICATORS (MALONDIALDEHYDE - MDA, PROTEIN OXIDATION - POX, PHOSPHOLIPASE A2 - PLA2 ACTIVITY) AND THE OXIDATIVE STATUS (SUPEROXIDE DISMUTASE (SOD) AND CATALASE ACTIVITIES) WERE DETERMINED IN THE BLOOD SAMPLES TAKEN AT THE PRE-HEMODIALYSIS TREATMENT, AT BASELINE (0 MONTHS) AND AFTER FOUR MONTHS. RESULTS: IN PATIENTS IN THE HATHA YOGA EXERCISE GROUP, LIPID PEROXIDATION, AS INDICATED BY MDA DECREASED BY 4.0% AFTER FOUR MONTHS (P = 0.096). THERE WAS ALSO A SIGNIFICANT REDUCTION IN THE ACTIVITY OF PLA FROM 2.68 +/- 0.02 IU / L TO 2.34 IU / L (- 12.7%; P = 0.010) AND POX FROM 2.28 +/- 0.02 NMOL / MG TO 2.22 +/- 0.01 NMOL / MG (- 22.6%; P = 0.0001). THE ACTIVITY OF SOD SIGNIFICANTLY INCREASED FROM 12.91 +/- 0.17 U / L TO 13.54 +/- 0.15 U / L (4.65%; P = 0.0001) AND CATALASE FROM 79.83 +/- 0.63 U / L TO 80.54 +/- 0.80 U / L (0.90%; P = 0.0001). THERE WAS A SIGNIFICANT CORRELATION BETWEEN THE PRE-HEMODIALYSIS OXIDATIVE STRESS PARAMETERS AT THE ZERO MONTH AND AFTER FOUR MONTHS FOR THE ACTIVITIES OF PLA (R = 0.440), CATALASE (R = 0.872), AND SOD (R = 0.775). CONCLUSIONS: THESE FINDINGS SUGGEST THAT THE HATHA YOGA EXERCISE HAS THERAPEUTIC, PREVENTATIVE, AND PROTECTIVE EFFECTS IN ESRD SUBJECTS, BY DECREASING OXIDATIVE STRESS. 2013 2 2295 31 THERAPEUTIC POTENTIAL OF YOGA PRACTICES IN MODIFYING CARDIOVASCULAR RISK PROFILE IN MIDDLE AGED MEN AND WOMEN. AIMS OF STUDY: TO STUDY EFFECT OF YOGA ON THE PHYSIOLOGICAL, PSYCHOLOGICAL WELL BEING, PSYCHOMOTOR PARAMETER AND MODIFYING CARDIOVASCULAR RISK FACTORS IN MILD TO MODERATE HYPERTENSIVE PATIENTS. METHODS: TWENTY PATIENTS (16 MALES, 4 FEMALES) IN THE AGE GROUP OF 35 TO 55 YEARS WITH MILD TO MODERATE ESSENTIAL HYPERTENSION UNDERWENT YOGIC PRACTICES DAILY FOR ONE HOUR FOR THREE MONTHS. BIOCHEMICAL, PHYSIOLOGICAL AND PSYCHOLOGICAL PARAMETERS WERE STUDIED PRIOR AND FOLLOWING PERIOD OF THREE MONTHS OF YOGA PRACTICES, BIOCHEMICAL PARAMETERS INCLUDED, BLOOD GLUCOSE, LIPID PROFILE, CATECHOLMINES, MDA, VIT. C CHOLINESTERASE AND URINARY VMA. PSYCHOLOGICAL EVALUATION WAS DONE BY USING PERSONAL ORIENTATION INVENTORY AND SUBJECTIVE WELL BEING. RESULTS: RESULTS SHOWED DECREASE IN BLOOD PRESSURE AND DRUG SCORE MODIFYING RISK FACTORS, I.E. BLOOD GLUCOSE, CHOLESTEROL AND TRIGLYCERIDES DECREASED OVERALL IMPROVEMENT IN SUBJECTIVE WELL BEING AND QUALITY OF LIFE. THERE WAS DECREASE IN VMA CATECHOLAMINE, AND DECREASE MDA LEVEL SUGGESTIVE DECREASE SYMPATHETIC ACTIVITY AND OXIDANT STRESS. CONCLUSION: YOGA CAN PLAY AN IMPORTANT ROLE IN RISK MODIFICATION FOR CARDIOVASCULAR DISEASES IN MILD TO MODERATE HYPERTENSION. 2002 3 986 34 EFFECTS OF HATHA YOGA EXERCISE ON PLASMA MALONDIALDEHYDE CONCENTRATION AND SUPEROXIDE DISMUTASE ACTIVITY IN FEMALE PATIENTS WITH SHOULDER PAIN. [PURPOSE] THE PURPOSE OF THIS STUDY WAS TO ANALYZE THE EFFECTS OF HATHA YOGA EXERCISE ON PLASMA MALONDIALDEHYDE (MDA) CONCENTRATION AND SUPEROXIDE DISMUTASE (SOD) ACTIVITY IN FEMALE PATIENTS WITH SHOULDER PAIN. [SUBJECTS] SUBJECTS COMPRISED 20 FEMALE PATIENTS WITH SHOULDER PAIN. [METHODS] SUBJECTS WERE DIVIDED INTO 2 GROUPS: A HATHA YOGA EXERCISE GROUP (N = 10) AND A CONTROL GROUP THAT PERFORMED NO EXERCISE (N = 10). THE SUBJECTS' BODY COMPOSITION, PLASMA MALONDIALDEHYDE CONCENTRATIONS, AND SUPEROXIDE DISMUTASE ACTIVITIES WERE MEASURED BEFORE AND AFTER A 16-WEEK HATHA YOGA EXERCISE PROGRAM. [RESULTS] AFTER THE 16-WEEK HATHA YOGA EXERCISE PROGRAM, THE EXERCISE GROUP HAD SIGNIFICANTLY LOWER PLASMA MDA CONCENTRATIONS THAN THE CONTROL GROUP. IN ADDITION, THE EXERCISE GROUP HAD SIGNIFICANTLY HIGHER PLASMA SOD ACTIVITY THAN THE CONTROL GROUP. [CONCLUSIONS] HATHA YOGA EXERCISE IMPROVES FLEXIBILITY, MUSCLE TONE AND STRENGTH, BALANCE, AND JOINT FUNCTION. OUR FINDINGS INDICATE THAT REGULAR AND CONTINUOUS YOGA EXERCISE EFFECTIVELY IMPROVED BODY COMPOSITION, DECREASE PLASMA MDA CONCENTRATION, AND INCREASE PLASMA SOD ACTIVITY IN FEMALE PATIENTS WITH SHOULDER PAIN. 2015 4 138 33 A PRELIMINARY REPORT ON THE ROLE OF YOGA ASANAS ON OXIDATIVE STRESS IN NON-INSULIN DEPENDENT DIABETES MELLITUS. NINETEEN SUBJECTS OF NON-INSULIN DEPENDENT DIABETES MELLITUS (NIDDM) BETWEEN THE AGE GROUP OF 30-60 YRS WERE STUDIED TO SEE THE EFFECT OF SPECIFIC YOGA ASANAS ON FASTING AND POSTPRANDIAL BLOOD GLUCOSE (FBG, PPG), SERUM MALONDIALDEHYDE (MDA) AND GLYCOSYLATED HEMOGLOBIN (HBA(1)) IN ADDITION TO DRUG TREATMENT AND DIET CONTROL. THE DURATION OF DIABETES RANGED FROM 1-10 YEARS. PATIENTS WITH RENAL, CARDIAC AND PROLIFERATIVE RETINAL DISEASES WERE EXCLUDED FROM THE STUDY. THE SAME PATIENTS SERVED AS THEIR OWN CONTROL. SUBJECTS WERE CALLED IN THE MORNING TO THE CARDIO-RESPIRATORY LABORATORY AND WERE GIVEN TRAINING BY A YOGA EXPERT. YOGA ASANAS INCLUDED SURYANAMSKAR, TADASAN, TRIKONASAN, PADMASAN, PRANAYAM, PASCHIMOTTANASAN, ARDHMATSYENDRASAN, PAVANMUKTHASAN, SARPASAN AND SHAVASAN. THE ASANAS WERE DONE EVERY DAY FOR 40 DAYS FOR 30-40 MIN. FBG, PPG, SERUM MDA AND HBA(1) WERE ESTIMATED BEFORE AND AFTER 40 DAYS OF YOGA ASANAS REGIMEN. SIGNIFICANT REDUCTION WAS SEEN IN FBG FROM 220 MG/DL TO 162 MG/DL, PPG FROM 311 MG/DL TO 255 MG/DL, MDA FROM 6 NMOL/L TO 3 NMOL/L AND HBA(1), FROM 8.8% TO 6.4%. SUBJECTS FELT BETTER AND WERE RELIEVED OF THEIR STRESSES AND HAD AN IMPROVEMENT IN THEIR DAY TO DAY PERFORMANCE. THE DECREASE WAS STATISTICALLY SIGNIFICANT (P<0.0001 FOR FBG AND PPG, P<0.001 FOR MDA AND FOR HBA(1)). 2001 5 2153 30 THE EFFECTS OF SUDARSHAN KRIYA YOGA ON SOME PHYSIOLOGICAL AND BIOCHEMICAL PARAMETERS IN MILD HYPERTENSIVE PATIENTS. AN OPEN LABEL INTERVENTION STUDY WAS UNDERTAKEN ON 26 MILD HYPERTENSIVES AND 26 APPARENTLY HEALTHY ADULTS (30-60 Y), FOR THE EFFECT OF SUDARSHAN KRIYA YOGA PRACTICE FOR TWO MONTHS AS COMPLEMENTARY THERAPY. IN THE HYPERTENSIVES, THERE WAS A SIGNIFICANT DECREASE IN DIASTOLIC BLOOD PRESSURE (P < 0.01), SERUM UREA (P < 0.01) AND PLASMA MDA (MALONDIALDEHYDE ADDUCTS) AS OXIDATIVE STRESS MARKER (P < 0.05). OTHER PARAMETERS; VIZ.; PLASMA LEVELS OF CHOLESTEROL, TRIGLYCERIDES, GLUCOSE, DID NOT CHANGE SIGNIFICANTLY (P > 0.1). THE PATTERN OF CHANGE IN MOST OF THE STUDY PARAMETERS WAS SUCH THAT VALUES ABOVE NORMAL RANGE WERE LOWERED BUT VALUES WITHIN NORMAL RANGE WERE UNALTERED. THE ACTION OF YOGA ON DIASTOLIC BLOOD PRESSURE, MALONDIALDEHYDE ADDUCTS AND KIDNEY FUNCTION IN HYPERTENSIVES WAS OF COUNTERACTIVE NATURE AND FELT TO BE DISTINCTLY DIFFERENT THAN THE EFFECT OF DRUGS. 2011 6 833 41 EFFECT OF YOGA ON OXIDATIVE STRESS IN ELDERLY WITH GRADE-I HYPERTENSION: A RANDOMIZED CONTROLLED STUDY. BACKGROUND AND OBJECTIVES: HYPERTENSION, ESPECIALLY IN ELDERLY IS A STRONG RISK FACTOR FOR CARDIOVASCULAR MORTALITY AND MORBIDITY. OXIDATIVE STRESS HAS BEEN IMPLICATED AS ONE OF THE UNDERLYING CAUSE OF HYPERTENSION. YOGA HAS BEEN FOUND TO CONTROL HYPERTENSION IN THE ELDERLY, BUT THE UNDERLYING BENEFITS OF MECHANISM IN RELATION TO OXIDATIVE STRESS REGULATION REMAINS UNCLEAR. THE PURPOSE OF THE STUDY WAS TO INVESTIGATE THE EFFECT OF YOGA ON OXIDATIVE STRESS IN ELDERLY WITH GRADE-I HYPERTENSION. METHODS: AN OPEN PARALLEL-ARM RANDOMISED CONTROLLED STUDY WAS CONDUCTED AT BLDE UNIVERSITY'S SHRI B.M.PATIL MEDICAL COLLEGE, HOSPITAL AND RESEARCH CENTRE, INDIA ON ELDERLY MALE INDIVIDUALS WITH GRADE-I HYPERTENSION (N=57, AGE 60-80 YEARS). STUDY (YOGA) GROUP WAS ASSIGNED FOR YOGA INTERVENTION AND CONTROL GROUP FOR WALKING FOR ONE HOUR IN THE MORNING FOR SIX DAYS IN A WEEK FOR THREE MONTHS UNDER THE SUPERVISION OF YOGA INSTRUCTOR AND PHYSICAL TRAINING INSTRUCTOR RESPECTIVELY. SERUM MALONDIALDEHYDE (MDA) AS AN INDICATOR OF OXIDATIVE STRESS AND ANTIOXIDANTS SUCH AS SERUM SUPEROXIDE DISMUTASE (SOD), REDUCED GLUTATHIONE (GSH) AND VITAMIN C LEVELS WERE ESTIMATED. RESULTS: YOGA PRACTICE FOR THREE MONTHS HAS SIGNIFICANTLY REDUCED SERUM MDA LEVEL (P<0.001), AND ENHANCED ANTIOXIDANTS LEVEL SUCH AS SOD ACTIVITY (P=0.007), SERUM GSH (P=0.002) AND VITAMIN C (P=0.002). IN THE CONTROL GROUP, WE OBSERVED A SIGNIFICANT INCREASE IN SERUM MDA LEVEL (P=0.04) AND REDUCTION IN SERUM VITAMIN C LEVEL (P=0.015) WITH NO SIGNIFICANT DIFFERENCE IN THE SOD ACTIVITY AND GSH LEVEL. CONCLUSION: THESE FINDINGS SUGGEST THAT YOGA IS AN EFFECTIVE MEANS TO REDUCE OXIDATIVE STRESS AND TO IMPROVE ANTIOXIDANT DEFENSE IN ELDERLY HYPERTENSIVE INDIVIDUALS. 2014 7 1968 35 SERUM MINERAL STATUS AND CLIMACTERIC SYMPTOMS IN PERIMENOPAUSAL WOMEN BEFORE AND AFTER YOGA THERAPY, AN ONGOING STUDY. BACKGROUND: MANY WOMEN REPORT AN INCREASED LEVEL OF ANXIETY, IRRITABILITY AND MOOD SWINGS DURING THEIR PERIMENOPAUSAL STATE. STUDIES SHOW THAT PHYSICALLY ACTIVE PEOPLE CAN REDUCE THEIR ANXIETY AND DEPRESSION BY PRACTICING YOGA. SERUM MINERALS SUCH AS CALCIUM, COPPER AND MAGNESIUM AND THE FERRO-OXIDASE, CERULOPLASMIN PLAY AN IMPORTANT ROLE IN THE BODY DURING THE PERIMENOPAUSAL PERIOD. OBJECTIVE: THE OBJECTIVE OF THIS STUDY IS TO ASSESS THE SERUM MINERAL STATUS, ANTHROPOMETRIC PARAMETERS AND CLIMACTERIC SYMPTOMS IN PERIMENOPAUSAL WOMEN BEFORE AND AFTER YOGA INTERVENTION. SUBJECTS AND METHODS: A TOTAL OF 30 SUBJECTS WITH PERIMENOPAUSAL SYMPTOMS, AGED BETWEEN 40 AND 60 YEARS (49.43 +/- 6.15) WERE INCLUDED IN THE STUDY. YOGA INTERVENTION WAS GIVEN ON A DAILY BASIS (45 MIN DURATION) FOR 12 WEEKS. THE CLIMACTERIC SYMPTOMS WERE ASSESSED BY GREENE'S CLIMACTERIC SCALE AND BIOCHEMICAL PARAMETERS WERE ANALYZED SPECTROPHOTOMETRICALLY. RESULTS: A SIGNIFICANT DECREASE IN THE WAIST HIP RATIO (P < 0.036) AND BODY MASS INDEX (P < 0.036) WAS OBSERVED AFTER YOGA INTERVENTION. SYSTOLIC (P < 0.064) AND DIASTOLIC (P < 0.082) BLOOD PRESSURE (BP) SHOWED MARGINAL DECREASE AFTER YOGA THERAPY. CLIMACTERIC SYMPTOMS IMPROVED SIGNIFICANTLY (P < 0.001) AFTER YOGA INTERVENTION. A SIGNIFICANT INCREASE (P < 0.001) IN SERUM CALCIUM AND COPPER AND A MARKED DECREASE IN SERUM MAGNESIUM (P < 0.05) AND CERULOPLASMIN (P < 0.028) LEVELS WAS OBSERVED, POST YOGA THERAPY. SERUM MAGNESIUM NEGATIVELY CORRELATED (R = -0.467, P < 0.035) WITH SYSTOLIC BP AFTER YOGA INTERVENTION. CONCLUSION: THE OVERALL CHANGES OBSERVED IN THE MINERAL STATUS AND CLIMACTERIC SYMPTOMS SUGGEST THAT YOGA THERAPY PROTOCOL CAN BE EFFECTIVELY USED TO IMPROVE THE QUALITY OF LIFE IN PERIMENOPAUSAL WOMEN. 2013 8 276 43 ADDITIONAL IMPROVEMENT OF RESPIRATORY TECHNIQUE ON VASCULAR FUNCTION IN HYPERTENSIVE POSTMENOPAUSAL WOMEN FOLLOWING YOGA OR STRETCHING VIDEO CLASSES: THE YOGINI STUDY. BACKGROUND: HYPERTENSION REMAINS HIGHLY PREVALENT IN POSTMENOPAUSAL WOMEN, ALONG WITH VASCULAR DYSFUNCTION AND INCREASED OXIDATIVE STRESS. IN SUCH CONTEXT, REGULAR EXERCISES, YOGA PRACTICE, AND SLOW BREATHING HAVE BEEN RECOMMENDED TO TREAT HYPERTENSION. HOWEVER, THE EFFECTS OF THE MULTIPLE COMPONENTS OF YOGA, INCLUDING THE RESPIRATORY TECHNIQUES INVOLVED IN THE PRACTICE, ON HYPERTENSION AND ON VASCULAR AND ENDOTHELIAL FUNCTION HAVE NEVER BEEN EVALUATED. OBJECTIVE: THIS STUDY AIMED TO INVESTIGATE THE ADDITIONAL EFFECTS OF RESPIRATORY TECHNIQUE ON VASCULAR FUNCTION AND OXIDATIVE STRESS PROFILE IN HYPERTENSIVE POSTMENOPAUSAL WOMEN (HPMWS) FOLLOWING YOGA OR STRETCHING VIDEO CLASSES. STUDY DESIGN: HYPERTENSIVE POSTMENOPAUSAL WOMEN WERE RECRUITED AND RANDOMIZED FOR 12 WEEKS, TWICE A WEEK, OF SUPERVISED YOGA OR STRETCHING VIDEO CLASSES OF 75 MIN FOR 12 WEEKS ASSOCIATED OR NOT WITH RESPIRATORY TECHNIQUE. BASELINE AND POST-INTERVENTION MEASUREMENTS INCLUDED PULSE WAVE VELOCITY (PWV), FLOW-MEDIATED DILATION (FMD), AND OXIDATIVE STRESS PARAMETERS. HYPERTENSIVE POSTMENOPAUSAL WOMEN (59 +/- 0.7 YEARS) WHO ENDED THE PROTOCOL WERE DISTRIBUTED INTO THREE GROUPS: (1) CONTROL GROUP (YOGA OR STRETCHING, C, N = 14); (2) YOGA + RESPIRATORY TECHNIQUE (Y+, N = 10); (3) STRETCHING + RESPIRATORY TECHNIQUE (S+, N = 9). RESULTS: DIASTOLIC BLOOD PRESSURE AND FMD [BASELINE: C: 6.94 +/- 1.97%, Y+: 7.05 +/- 1.65%, AND S+: 3.54 +/- 2.01% VS. POST: C: 16.59 +/- 3.46% (P = 0.006), Y+: 13.72 +/- 2.81% (P = 0.005), AND S+: 11.79 +/- 0.99% (P = 0.0001)] HAVE SIGNIFICANTLY INCREASED IN ALL GROUPS WHEN BASELINE AND POST-PRACTICE VALUES WERE COMPARED. HOWEVER, RESTING HEART RATE AND PWV [BASELINE: Y+: 10.44 +/- 3.69 AND S+: 9.50 +/- 0.53 M/S VS. POST: Y+: 9.45 +/- 0.39 (P = 0.003) AND S+: 8.02 +/- 0.47 M/S (P = 0.003)] DECREASED SIGNIFICANTLY ONLY IN THE Y+ AND S+ GROUPS (BASELINE VS. POST). SYSTEMIC ANTIOXIDANT ENZYME ACTIVITIES (SUPEROXIDE DISMUTASE AND CATALASE) INCREASED IN ALL GROUPS, AND HYDROGEN PEROXIDE AND LIPOPEROXIDATION REDUCED IN Y+ AND S+ (BASELINE VS. POST). CONCLUSIONS: TWELVE WEEKS OF YOGA OR STRETCHING VIDEO CLASSES PROMOTED POSITIVE CHANGES IN SEVERAL OUTCOMES GENERALLY REGARDED AS CARDIOVASCULAR RISK FACTORS IN HPMWS, AND THESE CHANGES WERE EVEN MORE PRONOUNCED BY THE ASSOCIATION WITH RESPIRATORY TECHNIQUE. 2020 9 2463 36 YOGA AS A THERAPEUTIC INTERVENTION FOR THE MANAGEMENT OF TYPE 2 DIABETES MELLITUS. PURPOSE: THIS STUDY AIMED TO INVESTIGATE THE EFFECTS OF 12 WEEKS YOGIC INTERVENTION ON BLOOD SUGAR AND LIPID PROFILE IN ELDER WOMEN WITH TYPE 2 DIABETES MELLITUS (T2DM). SUBJECTS AND METHODS: TWENTY ELDERLY (AGE RANGE 55-70 YEARS) T2DM WOMEN WERE DIVIDED INTO TWO GROUPS, NAMELY, YOGIC INTERVENTION GROUP (YIG: N = 10, AGE 64.70 +/- 4.03, BODY MASS INDEX [BMI] 24.26 +/- 3.40) AND CONTROL GROUP (CG: N = 10, AGE 64.40 +/- 4.79, BMI 24.28 +/- 2.36). YIG UNDERWENT YOGA PRACTICE (ASANAS, KRIYAS, PRANAYAMAS) FOR 12 WEEKS (3 SESSIONS/WEEK), WHILE THE CG CONTINUED THEIR USUAL ROUTINE ACTIVITIES. STANDING HEIGHT, BODY WEIGHT, BMI, BLOOD SUGAR, AND LIPID PROFILE WERE MEASURED BEFORE COMMENCEMENT AND AFTER 6 AND 12 WEEKS OF YOGIC INTERVENTION IN BOTH GROUPS. RESULTS: THERE WAS A SIGNIFICANT (P < 0.01) DECREASE IN FASTING PLASMA GLUCOSE, POSTPRANDIAL BLOOD SUGAR, TOTAL CHOLESTEROL, TRIGLYCERIDES, LOW-DENSITY LIPOPROTEIN, AND VERY LOW DENSITY LIPOPROTEIN, WITH A SIGNIFICANT (P < 0.01) INCREASE IN HIGH-DENSITY LIPOPROTEIN LEVEL FROM ITS INITIAL VALUE IN YIG, WHILE SHOWING INSIGNIFICANT RESULT IN CG. CONCLUSION: IT CAN BE SAID THAT YOGIC INTERVENTION MAY HAVE THE BENEFICIAL EFFECTS ON BLOOD SUGAR AND LIPID PROFILE IN ELDERLY WOMEN WITH T2DM. 2018 10 1933 34 ROLE OF YOGA IN MODIFYING CERTAIN CARDIOVASCULAR FUNCTIONS IN TYPE 2 DIABETIC PATIENTS. OBJECTIVES: 1. TO STUDY THE EFFECT OF FORTY DAYS OF YOGIC EXERCISES ON CARDIAC FUNCTIONS IN TYPE 2 DIABETICS. 2. TO STUDY THE EFFECT OF FORTY DAYS OF YOGIC EXERCISES ON BLOOD GLUCOSE LEVEL, GLYCOSYLATED HEMOGLOBIN. METHODS: THE PRESENT STUDY DONE IN TWENTY-FOUR TYPE 2 DM CASES PROVIDES METABOLIC AND CLINICAL EVIDENCE OF IMPROVEMENT IN GLYCAEMIC CONTROL AND AUTONOMIC FUNCTIONS. THESE MIDDLE-AGED SUBJECTS WERE TYPE II DIABETICS ON ANTIHYPERGLYCAEMIC AND DIETARY REGIMEN. THEIR BASELINE FASTING AND POSTPRANDIAL BLOOD GLUCOSE AND GLYCOSYLATED HB WERE MONITORED ALONG WITH AUTONOMIC FUNCTION STUDIES. THE EXPERT GAVE THESE PATIENTS TRAINING IN YOGA ASANAS AND THEY PURSUED THOSE 30-40 MIN/DAY FOR 40 DAYS UNDER GUIDANCE. THESE ASANAS CONSISTED OF 13 WELL KNOWN POSTURES, DONE IN A SEQUENCE. AFTER 40 DAYS OF YOGA ASANAS REGIMEN, THE PARAMETERS WERE REPEATED. RESULTS: THE RESULTS INDICATE THAT THERE WAS SIGNIFICANT DECREASE IN FASTING BLOOD GLUCOSE LEVELS FROM BASAL 190.08 +/- 18.54 IN MG/DL TO 141.5 +/- 16.3 IN MG/DL AFTER YOGA REGIMEN. THE POST PRANDIAL BLOOD GLUCOSE LEVELS DECREASED FROM 276.54 +/- 20.62 IN MG/DL TO 201.75 +/- 21.24 IN MG/DL, GLYCOSYLATED HEMOGLOBIN SHOWED A DECREASE FROM 9.03 +/- 0.29% TO 7.83 +/- 0.53% AFTER YOGA REGIMEN. THE PULSE RATE, SYSTOLIC AND DIASTOLIC BLOOD PRESSURE DECREASED SIGNIFICANTLY (FROM 86.45 +/- 2.0 TO 77.65 +/- 2.5 PULSE/MIN, FROM 142.0 +/- 3.9 TO 126.0 +/- 3.2 MM OF HG AND FROM 86.7 +/- 2.5 MM OF HG TO 75.5 +/- 2.1 MM OF HG AFTER YOGA REGIMEN RESPECTIVELY). CORRECTED QT INTERVAL (QTC) DECREASED FROM 0.42 +/- 0.0 TO 0.40 +/- 0.0. CONCLUSION: THESE FINDINGS SUGGEST THAT BETTER GLYCAEMIC CONTROL AND STABLE AUTONOMIC FUNCTIONS CAN BE OBTAINED IN TYPE 2 DM CASES WITH YOGA ASANAS AND PRANAYAMA. THE EXACT MECHANISM AS TO HOW THESE POSTURES AND CONTROLLED BREATHING INTERACT WITH SOMATO-NEURO-ENDOCRINE MECHANISM AFFECTING METABOLIC AND AUTONOMIC FUNCTIONS REMAINS TO BE WORKED OUT. 2004 11 359 31 ASSOCIATION OF LEUKOCYTE TELOMERE LENGTH WITH OXIDATIVE STRESS IN YOGA PRACTITIONERS. OBJECTIVE: YOGA IS A MIND-BODY MODULATION TECHNIQUE THAT HAS BEEN SHOWN TO HAVE BENEFICIAL EFFECTS ON VARIOUS DISEASES RELATED TO VARIOUS SYSTEMS IN THE BODY. HOWEVER, THE MOLECULAR BASIS OF MECHANISM OF ACTION IS NOT CLEAR. HENCE, THIS STUDY WAS DESIGNED TO STUDY THE LEUKOCYTE TELOMERE BIOLOGY AND ITS RELATION WITH HOMOCYSTEINE AND OXIDATIVE STRESS IN YOGA PRACTITIONERS. MATERIALS AND METHODS: THIS IS A PROSPECTIVE CASE-CONTROL STUDY INVOLVING YOGA PRACTITIONERS AGED 30-40 Y WITH MINIMUM OF TWO YEARS YOGA PRACTICE (YOGA GROUP) AND AGE, GENDER AND BODY MASS INDEX MATCHED SEDENTARY HEALTHY GENERAL POPULATION WITH NO MEDICAL PROBLEMS (CONTROL GROUP). LEUKOCYTE TELOMERE LENGTH (LTL) WAS MEASURED BY USING QUANTITATIVE PCR (QPCR), FASTING PLASMA HOMOCYSTEINE WAS MEASURED BY A RAPID HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY ASSAY AND THE OXIDATIVE STRESS WAS ASSESSED WITH TOTAL ANTIOXIDANT STATUS (TAOS), MALONDIALDEHYDE (MDA) MEASURED BY CALORIMETRY. RESULTS: THE LTL WAS SHORTER IN CONTROL GROUP THAN IN YOGA GROUP (P<0.001). THE TAOS WAS MORE IN YOGA GROUP WHEN COMPARED TO CONTROL GROUP (P=0.008), MDA AND HOMOCYSTEINE WAS HIGH IN CONTROL GROUP WHEN COMPARED TO YOGA GROUP (P<0.001). FURTHER, THE LTL WAS POSITIVELY CORRELATED WITH TAOS (R=0.841, P<0.001) AND NEGATIVELY CORRELATED WITH MDA (R=-0.931, P<0.001) AND HOMOCYSTEINE (R=-0.756, P<0.001). CONCLUSION: THE LTL IS WELL-PRESERVED IN PEOPLE WHO PRACTICE YOGA REGULARLY WITH LOWER SYSTEMIC OXIDATIVE STRESS COMPARED TO THOSE WHO HAVE A RELATIVELY SEDENTARY LIFESTYLE DESPITE LACK OF ANY MEDICAL DISORDERS. THE HABITUAL YOGA PRACTICE SEEMS TO INHIBIT REPLICATIVE CELLULAR SENESCENCE. 2015 12 185 37 A RANDOMIZED CONTROLLED TRIAL TO STUDY THE EFFECT OF YOGA THERAPY ON CARDIAC FUNCTION AND N TERMINAL PRO BNP IN HEART FAILURE. AIMS: THE PURPOSE OF THIS STUDY WAS TO EVALUATE WHETHER YOGA TRAINING IN ADDITION TO STANDARD MEDICAL THERAPY CAN IMPROVE CARDIAC FUNCTION AND REDUCE N TERMINAL PRO B-TYPE NATRIURETIC PEPTIDE (NT PRO BNP) IN HEART FAILURE (HF). METHODS: 130 PATIENTS WERE RECRUITED AND RANDOMIZED INTO TWO GROUPS: CONTROL GROUP (CG) (N = 65), YOGA GROUP (YG). IN YG, 44 PATIENTS AND IN CG, 48 PATIENTS COMPLETED THE STUDY. CARDIAC FUNCTION USING LEFT VENTRICULAR EJECTION FRACTION (LVEF), MYOCARDIAL PERFORMANCE INDEX (TEI INDEX), AND NT PRO BNP, A BIOMARKER OF HF, WAS ASSESSED AT BASELINE AND AFTER 12 WEEKS. RESULT: IMPROVEMENT IN LVEF, TEI INDEX, AND NT PRO BNP WERE STATISTICALLY SIGNIFICANT IN BOTH THE GROUPS. FURTHERMORE, WHEN THE CHANGES IN BEFORE AND AFTER 12 WEEKS WERE IN PERCENTAGE, LVEF INCREASED 36.88% IN THE YG AND 16.9% IN THE CG, TEI INDEX WAS REDUCED 27.87% IN THE YG AND 2.79% IN THE CG, NT PRO BNP WAS REDUCED 63.75% IN THE YG AND 10.77% IN THE CG. THE BETWEEN GROUP COMPARISONS FROM PRE TO POST 12 WEEKS WERE SIGNIFICANT FOR YG IMPROVEMENTS (LVEF, P < 0.01, TEI INDEX, P < 0.01, NT PRO BNP, P < 0.01). CONCLUSION: THESE RESULTS INDICATE THAT THE ADDITION OF YOGA THERAPY TO STANDARD MEDICAL THERAPY FOR HF PATIENTS HAS A MARKEDLY BETTER EFFECT ON CARDIAC FUNCTION AND REDUCED MYOCARDIAL STRESS MEASURED USING NT PRO BNP IN PATIENTS WITH STABLE HF. 2014 13 1399 34 IMPACT OF YOGA NIDRA ON MENSTRUAL ABNORMALITIES IN FEMALES OF REPRODUCTIVE AGE. OBJECTIVES: THE AIM OF THIS STUDY WAS TO OBSERVE THE EFFECT OF YOGA NIDRA PRACTICE ON HORMONE LEVELS IN PATIENTS WHO HAD MENSTRUAL IRREGULARITIES. DESIGN: THE STUDY WAS A RANDOMIZED CONTROLLED TRIAL. SETTINGS/LOCATION: THE STUDY WAS CONDUCTED IN THE DEPARTMENT OF OBSTETRICS AND GYNECOLOGY AT CHHATRAPATI SAHUJI MAHARAJ MEDICAL UNIVERSITY, UTTAR PRADESH, LUCKNOW, INDIA. SUBJECTS WERE DIVIDED RANDOMLY INTO 2 GROUPS-AN INTERVENTION AND A CONTROL GROUP, WITH 75 SUBJECTS IN EACH GROUP. OF THESE SUBJECTS, 126 COMPLETED THE STUDY PROTOCOL. SUBJECTS: THIS STUDY INVOLVED 150 SUBJECTS WITH MENSTRUAL IRREGULARITIES; 126 OF WHOM COMPLETED THE PROTOCOL. INTERVENTIONS: THE INTERVENTION WAS THE PRACTICE OF YOGA NIDRA. THE YOGIC INTERVENTION DURATION WAS 35-40 MINUTES/DAY, FIVE TIMES/WEEK FOR 6 MONTHS. AN ESTIMATION OF HORMONAL PROFILE WAS DONE FOR BOTH GROUPS AT BASELINE AND AFTER 6 MONTHS. RESULTS: THYROID-STIMULATING HORMONE (P<0.002), FOLLICLE-STIMULATING HORMONE (P<0.02), LUTEINIZING HORMONE (P<0.001), AND PROLACTIN (P<0.02) WERE DECREASED SIGNIFICANTLY IN THE INTERVENTION GROUP, COMPARED WITH THE CONTROL GROUP. CONCLUSIONS: THE PRESENT STUDY DEMONSTRATED THE EFFICACY OF YOGA NIDRA ON HORMONE PROFILES IN PATIENTS WITH MENSTRUAL IRREGULARITIES. YOGA NIDRA PRACTICE WAS HELPFUL IN PATIENTS WITH HORMONE IMBALANCES, SUCH AS DYSMENORRHEA, OLIGOMENORRHEA, MENORRHAGIA, METRORRHAGIA, AND HYPOMENORRHEA. 2013 14 437 31 CARDIOVASCULAR AND METABOLIC EFFECTS OF INTENSIVE HATHA YOGA TRAINING IN MIDDLE-AGED AND OLDER WOMEN FROM NORTHERN MEXICO. BACKGROUND: HATHA YOGA (HY) CAN BE AN ALTERNATIVE TO IMPROVE PHYSICAL ACTIVITY IN MIDDLE-AGED AND OLDER WOMEN. HOWEVER, CONVENTIONAL HY (CHY) EXERCISING MAY NOT RESULT IN ENOUGH TRAINING STIMULUS TO IMPROVE CARDIOVASCULAR FITNESS. THE PURPOSE OF THIS STUDY WAS TO EVALUATE THE EFFECT OF AN INTENSIVE HY INTERVENTION (IHY) ON CARDIOVASCULAR RISK FACTORS IN MIDDLE-AGED AND OLDER WOMEN FROM NORTHERN MEXICO. MATERIALS AND METHODS: IN THIS PROSPECTIVE QUASIEXPERIMENTAL DESIGN, FOUR MIDDLE-AGED AND NINE OLDER CHY PRACTICING FEMALES (YOGINIS) WERE ENROLLED INTO AN 11-WEEK IHY PROGRAM CONSISTING OF 5 SESSIONS/WEEK FOR 90 MIN (55 SESSIONS). THE PROGRAM ADHERENCE, ASANA PERFORMANCE, AND WORK INTENSITY WERE ASSESSED ALONG THE INTERVENTION. ANTHROPOMETRIC [BODY MASS INDEX (BMI), % BODY FAT AND SIGMA SKIN FOLDS], CARDIOVASCULAR FITNESS [MAXIMAL EXPIRED AIR VOLUME (VE(MAX)), MAXIMAL O(2) CONSUMPTION (VO(2MAX)), MAXIMAL HEART RATE (HR(MAX)), SYSTOLIC (BPS) AND DIASTOLIC BLOOD PRESSURE (BPD)], BIOCHEMICAL [GLUCOSE, TRIACYLGLYCEROLS (TAG), TOTAL CHOLESTEROL (TC), HIGH-DENSITY LIPOPROTEIN CHOLESTEROL (HDL-C), AND LOW-DENSITY LIPOPROTEIN CHOLESTEROL (LDL-C)], AND DIETARY PARAMETERS WERE EVALUATED BEFORE AND AFTER IHY. RESULTS: DAILY CALORIC INTAKE (~1,916 KCAL/DAY), PROGRAM ADHERENCE (~85%), AND EXERCISING SKILLS (ASANA PERFORMANCE) WERE SIMILAR IN BOTH MIDDLE-AGED AND OLDER WOMEN. THE IHY PROGRAM DID NOT MODIFY ANY ANTHROPOMETRIC MEASUREMENTS. HOWEVER, IT INCREASED VO(2MAX) AND VE(MAX) AND HDL-C WHILE TAG AND LDL-C REMAINED STABLE IN BOTH MIDDLE-AGED AND OLDER GROUPS (P < 0.01). CONCLUSIONS: THE PROPOSED IHY PROGRAM IMPROVES DIFFERENT CARDIOVASCULAR RISK FACTORS (NAMELY VO(2MAX) AND HDL-C) IN MIDDLE-AGED AND OLDER WOMEN. 2009 15 839 23 EFFECT OF YOGA ON PLASMA GLUCOSE, LIPID PROFILE, BLOOD PRESSURE AND INSULIN REQUIREMENT IN A PATIENT WITH TYPE 1 DIABETES MELLITUS. OBJECTIVES: THE OBJECTIVE OF THE STUDY IS TO EVALUATE THE SHORT-TERM EFFECT OF YOGA ON PLASMA GLUCOSE, LIPID PROFILE, BLOOD PRESSURE AND INSULIN REQUIREMENT IN A PATIENT WITH TYPE 1 DIABETES MELLITUS (T1DM). CASE PRESENTATION: A 28-YEARS OLD FEMALE WAS DIAGNOSED WITH T1DM AT THE AGE OF SEVEN. SHE WAS UNDER HUMAN MIXTARD INSULIN 30-70, THRICE/DAY FOR 15-15-15 UNITS. SHE HAD A HISTORY OF POOR GLYCEMIC CONTROL, DIABETIC KETOACIDOSIS AND HYPOGLYCEMIC SHOCK. AT THE AGE OF 27, SHE GOT ADMITTED WITH COMPLAINTS OF GENERAL WEAKNESS, JOINTS STIFFNESS AND WEIGHT LOSS IN OUR HOLISTIC HEALTH CENTRE AND UNDERWENT TWO WEEKS OF YOGA. RESULTS SHOWED A BETTER REDUCTION IN THE PLASMA GLUCOSE LEVELS, LIPID PROFILE, BLOOD PRESSURE AND INSULIN DOSE AND AN INCREASE IN HEMOGLOBIN LEVELS WITH NO EPISODES OF HYPOGLYCEMIA AFTER YOGA. CONCLUSIONS: YOGA MIGHT BE CONSIDERED AS A SAFER AND EFFECTIVE ADJUVANT IN THE MANAGEMENT OF T1DM. 2021 16 798 43 EFFECT OF YOGA LIFESTYLE IN PATIENTS WITH HEART FAILURE: A RANDOMIZED CONTROL TRIAL. BACKGROUND: IN SPITE OF SIGNIFICANT ADVANCES IN THE MANAGEMENT OF HEART FAILURE (HF), MORBIDITY AND MORTALITY REMAIN HIGH. THEREFORE, THERE IS A NEED FOR ADDITIONAL STRATEGIES. WE DID A RANDOMIZED CLINICAL TRIAL TO STUDY EFFECT OF YOGA IN PATIENTS WITH HF IN TERMS OF QUALITY OF LIFE (QOL), LEFT VENTRICLE EJECTION FRACTION (LVEF), C-REACTIVE PROTEIN (CRP), AND NTPROBNP. MATERIALS AND METHODS: 60 PATIENTS WITH STABLE HF NEW YORK HEART ASSOCIATION CLASS II WITH LVEF 30%-40% WERE RANDOMIZED INTO CONTROL GROUP (CG) AND YOGA GROUP (YG). CG RECEIVED THE GUIDELINE-BASED THERAPY AND YG IN ADDITION PRACTICED THE YOGA, ONE HOUR DAILY FOR 3 MONTHS. ALL PATIENTS WERE ASSESSED FOR QOL, CRP, NTPROBNP, AND LVEF AT BASELINE AND AFTER 3 MONTHS. RESULTS: A SIGNIFICANT DIFFERENCE WAS OBSERVED IN ALL FOUR PARAMETERS IN THE YG AS COMPARED TO THE CG (P < 0.01) AFTER 12 WEEKS. QOL AS ASSESSED BY MINNESOTA LIVING WITH HEART FAILURE QUESTIONNAIRE SCORE IMPROVED SIGNIFICANTLY IN YG AS COMPARED TO CG (10 V/S 14, P < 0.001). THERE WAS A SIGNIFICANT IMPROVEMENT WITHIN YG IN TERMS OF LVEF (33.4-36.8, P = 0.001), AND THE PERCENTAGE CHANGE IN LVEF WAS SIGNIFICANT BETWEEN THE GROUPS (10% V/S 5%, P = 0.001). NTPROBNP ALSO SIGNIFICANTLY REDUCED BY 69.8% FROM 755 TO 220 PMOL/L IN YG AS COMPARED TO 39.3% IN CG (679-406 PMOL/L). CRP DECREASED BY 49.3% (5.36-2.73 MG/L) IN YG AND 35.8% (5.39-3.45 MG/L) IN CG. CONCLUSION: THE RESULT OF THIS PILOT STUDY SUGGESTS THAT ADDITION OF YOGA TO GUIDELINE-BASED THERAPY FOR HF PATIENTS SIGNIFICANTLY IMPROVES QOL, LVEF, AND NTPROBNP AND REDUCES CRP LEVEL. LARGER STUDIES ARE NEEDED TO CONFIRM THESE FINDINGS. 2022 17 90 35 A MODIFIED YOGA-BASED EXERCISE PROGRAM IN HEMODIALYSIS PATIENTS: A RANDOMIZED CONTROLLED STUDY. AIM: TO EVALUATE THE EFFECTS OF A YOGA-BASED EXERCISE PROGRAM ON PAIN, FATIGUE, SLEEP DISTURBANCE, AND BIOCHEMICAL MARKERS IN HEMODIALYSIS PATIENTS. MATERIALS AND METHODS: IN 2004 A RANDOMIZED CONTROLLED TRIAL WAS CARRIED OUT IN THE OUTPATIENT HEMODIALYSIS UNIT OF THE NEPHROLOGY DEPARTMENT, ULUDAG UNIVERSITY FACULTY OF MEDICINE. CLINICALLY STABLE HEMODIALYSIS PATIENTS (N=37) WERE INCLUDED AND FOLLOWED IN TWO GROUPS: THE MODIFIED YOGA-BASED EXERCISE GROUP (N=19) AND THE CONTROL GROUP (N=18). YOGA-BASED EXERCISES WERE DONE IN GROUPS FOR 30 MIN/DAY TWICE A WEEK FOR 3 MONTHS. ALL OF THE PATIENTS IN THE YOGA AND CONTROL GROUPS WERE GIVEN AN ACTIVE RANGE OF MOTION EXERCISES TO DO FOR 10 MIN AT HOME. THE MAIN OUTCOME MEASURES WERE PAIN INTENSITY (MEASURED BY THE VISUAL ANALOGUE SCALE, VAS), FATIGUE (VAS), SLEEP DISTURBANCE (VAS), AND GRIP STRENGTH (MMHG); BIOCHEMICAL VARIABLES-- UREA, CREATININE, CALCIUM, ALKALINE PHOSPHATASE, PHOSPHORUS, CHOLESTEROL, HDL-CHOLESTEROL, TRIGLYCERIDE, ERYTHROCYTE, HEMATOCRIT--WERE EVALUATED. RESULTS: AFTER A 12-WEEK INTERVENTION, SIGNIFICANT IMPROVEMENTS WERE SEEN IN THE VARIABLES: PAIN -37%, FATIGUE -55%, SLEEP DISTURBANCE -25%, GRIP STRENGTH +15%, UREA -29%, CREATININE -14%, ALKALINE PHOSPHATASE -15%, CHOLESTEROL -15%, ERYTHROCYTE +11%, AND HEMATOCRIT COUNT +13%; NO SIDE-EFFECTS WERE SEEN. IMPROVEMENT OF THE VARIABLES IN THE YOGA-BASED EXERCISE PROGRAM WAS FOUND TO BE SUPERIOR TO THAT IN THE CONTROL GROUP FOR ALL THE VARIABLES EXCEPT CALCIUM, PHOSPHORUS, HDL-CHOLESTEROL AND TRIGLYCERIDE LEVELS. CONCLUSION: A SIMPLIFIED YOGA-BASED REHABILITATION PROGRAM IS A COMPLEMENTARY, SAFE AND EFFECTIVE CLINICAL TREATMENT MODALITY IN PATIENTS WITH END-STAGE RENAL DISEASE. 2007 18 534 30 COMPARISON OF YOGA AND WALKING-EXERCISE ON CARDIAC TIME INTERVALS AS A MEASURE OF CARDIAC FUNCTION IN ELDERLY WITH INCREASED PULSE PRESSURE. OBJECTIVE: ARTERIAL AGING ALONG WITH INCREASED BLOOD PRESSURE(BP) HAS BECOME THE MAJOR CARDIOVASCULAR(CV) RISK IN ELDERLY. THE AIM OF THE STUDY WAS TO COMPARE THE EFFECTS OF YOGA PROGRAM AND WALKING-EXERCISE ON CARDIAC FUNCTION IN ELDERLY WITH INCREASED PULSE PRESSURE (PP). METHODS: AN OPEN LABEL, PARALLEL-GROUP RANDOMIZED CONTROLLED STUDY DESIGN WAS ADOPTED. ELDERLY INDIVIDUALS AGED >/=60 YEARS WITH PP>/=60MMHG WERE RECRUITED FOR THE STUDY. YOGA (STUDY) GROUP (N=30) WAS ASSIGNED FOR YOGA TRAINING AND WALKING (EXERCISE) GROUP (N=30) FOR WALKING WITH LOOSENING PRACTICES FOR ONE HOUR IN THE MORNING FOR 6DAYS IN A WEEK FOR 3 MONTHS. THE OUTCOME MEASURES WERE CARDIAC TIME INTERVALS DERIVED FROM PULSE WAVE ANALYSIS AND ECG: RESTING HEART RATE (RHR), DIASTOLIC TIME(DT), VENTRICULAR EJECTION TIME(LVET), UPSTROKE TIME(UT), EJECTION DURATION INDEX (ED%), PRE-EJECTION PERIOD (PEP), RATE PRESSURE PRODUCT (RPP) AND PERCENTAGE OF MEAN ARTERIAL PRESSURE (%MAP). RESULTS: THE MEAN WITHIN-YOGA GROUP CHANGE IN RHR(BPM) WAS 4.41 (P=0.031), PD(MS): -50.29 (P=0.042), DT(MS): -49.04 (P=0.017), ED%: 2.107 (P=0.001), ES(MMHG/MS): 14.62 (P=0.118), ET(MS): -0.66 (P=0.903), UT(MS): -2.54 (P=0.676), PEP(MS): -1.25 (P=0.11) AND %MAP: 2.08 (P=0.04). THE MEAN WITHIN-CONTROL GROUP CHANGE IN HR (BPM) WAS 0.35 (P=0.887), PD (MS): 11.15(P=0.717), DT (MS): 11.3 (P=0.706), ED%: -0.101 (P=0.936), ES (MMHG/MS): 0.75 (P=0.926), ET(MS): 2.2 (P=0.721), UT(MS):4.7(P=455), PEP (MS): 2.1(P=0.11), %MAP: 0.65 (P=0.451). A SIGNIFICANT DIFFERENCE BETWEEN-GROUP WAS FOUND IN RHR (P=0.036), PD (P=0.02), ED% (P=0.049), LVET (P=0.048), DT (P=0.02) AND RPP (P=0.001). CONCLUSIONS: YOGA PRACTICE FOR 3 MONTHS SHOWED A SIGNIFICANT IMPROVEMENT IN DIASTOLIC FUNCTION WITH A MINIMAL CHANGE IN SYSTOLIC FUNCTION. YOGA IS MORE EFFECTIVE THAN WALKING IN IMPROVING CARDIAC FUNCTION IN ELDERLY WITH HIGH PP. 2017 19 808 36 EFFECT OF YOGA ON ARTERIAL STIFFNESS IN ELDERLY SUBJECTS WITH INCREASED PULSE PRESSURE: A RANDOMIZED CONTROLLED STUDY. OBJECTIVE: WE AIMED TO DETERMINE THE EFFECT OF YOGA ON ARTERIAL FUNCTION IN ELDERLY WITH INCREASED PULSE PRESSURE (PP). DESIGN: RANDOMIZED CONTROLLED STUDY WITH TWO PARALLEL GROUPS. PARTICIPANTS: ELDERLY SUBJECTS WITH PP>/=60 MMHG (N=60). INTERVENTIONS: YOGA GROUP (N=30) WAS ASSIGNED FOR YOGA TRAINING AND BRISK-WALKING (BW) GROUP (N=30) FOR BRISK-WALK WITH STRETCHING EXERCISE FOR 1H IN THE MORNING FOR 6 DAYS IN A WEEK FOR 12 WEEKS. MAIN OUTCOME MEASURES: ARTERIAL STIFFNESS MEASURES: BRACHIAL-ANKLE PULSE WAVE VELOCITY (BAPWV), CAROTID-FEMORAL PULSE WAVE VELOCITY (C-F PWV), AORTIC AUGMENTATION INDEX (AIX@75), ARTERIAL STIFFNESS INDEX AT BRACHIAL (BASI) AND TIBIAL ARTERIES (AASI). TOTAL SERUM NITRIC OXIDE CONCENTRATION (NOX) AS AN INDEX OF ENDOTHELIAL FUNCTION. HEART RATE VARIABILITY (HRV) MEASURES: LOW FREQUENCY AND HIGH FREQUENCY IN NORMALIZED UNITS (LFNU, HFNU) AND LF/HF RATIO. RESULTS: THE MEAN BETWEEN-GROUP CHANGE (WITH 95% CI) IN ARTERIAL STIFFNESS: C-F PWV(M/S) [1.25(0.59-1.89); P<0.001], BAPWV(M/S) [1.96(0.76-3.16), P<0.01], AIX@75 [3.07(0.24-5.89), P=0.066], AASI [8.3(4.06-12.53), P<0.001]; ENDOTHELIAL FUNCTION INDEX: NO(MUMOL/L) [-9.03(-14.57 TO -3.47), P<0.001]; SBP(MMHG) [14.23(12.03-16.44), P<0.001], DBP(MMHG) [0.1(-1.95-2.15), P=0.38], PP(MMHG) [14.07(11.2-16.92), P<0.001], MAP(MMHG) [4.7(3.08-6.32), P<0.001]; AND CARDIAC AUTONOMIC FUNCTION: LF(NU) [4.81(1.54-8.08), P<0.01], HF(NU) [-4.13(-7.57 TO -0.69), P<0.01], LF/HF RATIO [0.84(0.3-1.37), P<0.001], INDICATE SIGNIFICANT DIFFERENCE IN EFFECTS OF TWO INTERVENTION ON ARTERIAL STIFFNESS, ENDOTHELIAL FUNCTION, BP AND CARDIAC AUTONOMIC ACTIVITY. THERE WAS SIGNIFICANT CHANGE WITHIN-YOGA GROUP IN VASCULAR FUNCTION, BP AND AUTONOMIC FUNCTION, WHILE NO SIGNIFICANT CHANGE WITHIN-BW GROUP WAS OBSERVED. CONCLUSION: OUR FINDINGS SUGGEST THAT YOGA PROGRAM OFFERED WAS MORE EFFECTIVE THAN BRISK-WALK IN REDUCING ARTERIAL STIFFNESS ALONG WITH BP IN ELDERLY INDIVIDUALS WITH INCREASED PP. YOGA CAN ALSO SIGNIFICANTLY REDUCE SYMPATHETIC ACTIVITY AND IMPROVE ENDOTHELIAL FUNCTION WITH ENHANCEMENT IN BIOAVAILABILITY OF NO. 2015 20 692 38 EFFECT OF COMMUNITY-BASED YOGA INTERVENTION ON OXIDATIVE STRESS AND GLYCEMIC PARAMETERS IN PREDIABETES: A RANDOMIZED CONTROLLED TRIAL. OBJECTIVES: TO STUDY THE EFFECTIVENESS OF YOGA INTERVENTION ON OXIDATIVE STRESS, GLYCEMIC STATUS, BLOOD PRESSURE AND ANTHROPOMETRY IN PREDIABETES. DESIGN: RANDOMIZED-CONTROLLED TRIAL. PARTICIPANTS: TWENTY NINE PREDIABETES SUBJECTS AGED 30-75 YEARS. SETTING: YOGA WAS CONDUCTED AT 4 DIFFERENT COMMUNITY DIABETES CLINICS IN MANGALORE, INDIA. INTERVENTIONS: PARTICIPANTS WERE RANDOMIZED TO EITHER 3-MONTH YOGA OR WAIT-LIST CONTROL GROUPS. MAIN OUTCOME MEASURES: MALONDIALDEHYDE, GLUTATHIONE, VITAMIN C, VITAMIN E, SUPEROXIDE DISMUTASE, PLASMA GLUCOSE, GLYCATED HAEMOGLOBIN, BMI, WAIST CIRCUMFERENCE, WAIST-TO-HIP RATIO AND BLOOD PRESSURE. RESULTS: YOGA INTERVENTION RESULTED IN A SIGNIFICANT DECLINE IN MALONDIALDEHYDE (P<0.001), RELATIVE TO THE CONTROL GROUP. IN COMPARISON WITH THE CONTROL, THERE WAS A SIGNIFICANT IMPROVEMENT IN BMI, WAIST CIRCUMFERENCE, SYSTOLIC BLOOD PRESSURE AND FASTING GLUCOSE LEVELS AT FOLLOW-UP. NO SIGNIFICANT IMPROVEMENT IN GLYCATED HAEMOGLOBIN, WAIST-TO-HIP RATIO OR ANY OF THE ANTIOXIDANTS WAS OBSERVED. CONCLUSIONS: YOGA INTERVENTION MAY BE HELPFUL IN CONTROL OF OXIDATIVE STRESS IN PREDIABETES SUBJECTS. YOGA CAN ALSO BE BENEFICIAL IN REDUCTION IN BMI, WAIST CIRCUMFERENCE, SYSTOLIC BLOOD PRESSURE AND FASTING GLUCOSE. EFFECT OF YOGA ON ANTIOXIDANT PARAMETERS WAS NOT EVIDENT IN THIS STUDY. THE FINDINGS OF THIS STUDY NEED TO BE CONFIRMED IN LARGER TRIALS INVOLVING ACTIVE CONTROL GROUPS. 2013