1  988 169 EFFECTS OF HATHA YOGA ON BLOOD PRESSURE, SALIVARY ALPHA-AMYLASE, AND CORTISOL FUNCTION AMONG NORMOTENSIVE AND PREHYPERTENSIVE YOUTH. OBJECTIVE: EVIDENCE IS ACCUMULATING, PREDOMINANTLY AMONG CLINICAL TRIALS IN ADULTS, THAT YOGA IMPROVES BLOOD PRESSURE (BP) CONTROL, WITH DOWNREGULATION OF THE HYPOTHALAMIC-PITUITARY-ADRENAL (HPA) AXIS AND THE SYMPATHETIC NERVOUS SYSTEM (SNS) PROJECTED AS UNDERLYING MECHANISMS. THIS PILOT STUDY ASSESSED WHETHER HATHA YOGA HAS THE POTENTIAL TO REDUCE BP AMONG YOUTH AND WHETHER DAMPENING OF THE SNS AND/OR HPA ACTIVITY IS A LIKELY PATHWAY OF CHANGE. DESIGN: THIRTY-ONE SEVENTH GRADERS WERE RANDOMLY ASSIGNED TO A HATHA YOGA PROGRAM (HYP) OR ATTENTION CONTROL (AC) MUSIC OR ART CLASS. BASELINE AND 3-MONTH EVALUATIONS INCLUDED RESTING BP; OVERNIGHT URINE SAMPLES; AND SALIVA COLLECTED AT BEDTIME, UPON AWAKENING, AND AT 30 AND 60 MINUTES AFTER AWAKENING FOR ALPHA-AMYLASE AND CORTISOL ASSAYS. RESULTS: TWENTY-EIGHT (14 IN THE HYP GROUP AND 14 IN THE AC GROUP) STUDENTS WERE ASSESSED BOTH BEFORE AND AFTER THE INTERVENTION. BP CHANGES FROM PRE- TO POST-INTERVENTION WERE -3.0/-2.0 MMHG FOR THE HYP GROUP AND -0.07/-0.79 MMHG FOR THE AC GROUP (P=0.30 AND 0.57, RESPECTIVELY). CHANGES IN SYSTOLIC BP (SBP)/DIASTOLIC BP (DBP) FOR THE PREHYPERTENSIVE (75TH-94TH PERCENTILES FOR SBP) SUBGROUP ANALYSES WERE -10.75/-8.25 MMHG FOR THE HYP GROUP (N=4) VERSUS 1.8/1.0 MMHG FOR THE AC GROUP (N=5) (P FOR SBP=0.02; P FOR DBP=0.09). ALTHOUGH NO STATISTICALLY SIGNIFICANT GROUP DIFFERENCES WERE OBSERVED WITH CHANGES IN SNS OR HPA AWAKENING CURVES (AREA UNDER CURVE FOR ALPHA-AMYLASE AND CORTISOL, RESPECTIVELY), A SMALL TO MODERATE EFFECT SIZE WAS SEEN FAVORING A REDUCTION OF ALPHA-AMYLASE ACTIVATION FOR THE HYP GROUP (COHEN D=0.34; PREHYPERTENSIVE D=0.20). CONCLUSIONS: A SCHOOL-BASED HATHA YOGA PROGRAM DEMONSTRATED POTENTIAL TO DECREASE RESTING BP, PARTICULARLY AMONG PREHYPERTENSIVE YOUTH. REDUCED SNS DRIVE MAY BE AN UNDERLYING NEUROHORMONAL PATHWAY BENEFICIALLY AFFECTED BY THE PROGRAM. A LARGE-SCALE EFFICACY/EFFECTIVENESS RANDOMIZED CLINICAL TRIAL IS WARRANTED.	2014	
                                                                                                                                      
2  263  45 ACUTE CARDIOVASCULAR RESPONSES TO A SESSION OF BIKRAM YOGA: A PILOT UNCONTROLLED TRIAL. INTRODUCTION: MAIN CARDIOVASCULAR PARAMETERS SUCH AS HEART RATE (HR), BLOOD PRESSURE, AND MYOCARDIAL OXYGEN CONSUMPTION (MOC) ARE TIGHTLY REGULATED BY A MULTIFACTORIAL, NONLINEAR CONTROL SYSTEM. INCREASED HR BECAUSE OF PHYSICAL ACTIVITY IS OFTEN ACCOMPANIED BY AN INCREASE IN BLOOD PRESSURE. POSTURAL CHANGES HAVE AN EFFECT ON THE BARORECEPTORS, AND STRETCHING EXERCISES AND ISOMETRIC CONTRACTIONS MODULATE MUSCLE MECHANORECEPTORS ELICITING INCREASES IN BLOOD PRESSURE. HOWEVER, A HOT ENVIRONMENT INCREASES THE CORE TEMPERATURE INDUCING VASODILATION AND PLASMA VOLUME CHANGES THAT MIGHT CONTRIBUTE TO A DROP IN BLOOD PRESSURE. DURING THE PRACTICE OF BIKRAM YOGA, ALL THESE FACTORS CONVERGE AND LITTLE IS KNOWN ABOUT THE RESULTING CHANGES IN BLOOD PRESSURE AND MOC. METHODS: SIXTEEN APPARENTLY HEALTHY FEMALE VOLUNTEERS, REGULAR PRACTITIONERS OF BIKRAM YOGA, WERE EVALUATED DURING A 90 MIN SESSION. SYSTOLIC BLOOD PRESSURE (SBP) AND DIASTOLIC BLOOD PRESSURE (DBP) WERE MEASURED IMMEDIATELY AFTER EACH POSTURE AND HR WAS MEASURED CONTINUOUSLY DURING THE PRACTICE. RESULTS: HR AND ESTIMATED MOC INCREASED SIGNIFICANTLY OVER BASELINE DURING THE EXERCISE (+62.3% AND +63.6%, RESPECTIVELY). HR MEAN VALUE ACROSS THE ENTIRE BIKRAM YOGA SESSION WAS 126.6 +/- 14.3 BPM REACHING A MAXIMUM OF 168.1 +/- 20.2 BPM. SBP WAS NOT SIGNIFICANTLY INCREASED OVER BASELINE AT ANY TIME DURING THE PRACTICE WITH A MEAN VALUE OF 117.0 +/- 10.1 MMHG AND DBP WAS SIGNIFICANTLY DECREASED OVER BASELINE MOST OF THE TIME (-10.1%, MEAN 71.2 +/- 7.3 MMHG) WITH PARTICULAR DECLINE TOWARD THE END OF THE PRACTICE DURING THE FLOOR POSTURES. CONCLUSIONS: DBP DURING THE PRACTICE OF BIKRAM YOGA WAS SIGNIFICANTLY DIFFERENT FROM THAT PREVIOUSLY REPORTED FOR NONHEATED HATHA YOGA FOR NORMOTENSIVE SUBJECTS. FURTHER STUDIES EVALUATING THE SAME GROUP AT BOTH CONDITIONS ARE NEEDED TO BETTER CHARACTERIZE THE MAGNITUDE OF THE CHANGES IN HR, SBP, DBP, AND MOC.	2019	
                                                                                                                                                                                                                          
3 2386  46 YOGA AIDS BLOOD PRESSURE RECOVERY AFTER EXPOSURE OF FOREHEAD TO COLD: A PILOT STUDY. CONTEXT: HYPOTENSION THAT OCCURS AFTER A SINGLE BOUT OF AEROBIC EXERCISE ALSO ATTENUATES THE VASCULAR RESPONSE TO DISCRETE STRESSORS, AN EFFECT THAT CAN LAST FOR HOURS. IT IS UNKNOWN WHETHER THE HYPOTENSIVE BENEFITS OF TRADITIONAL EXERCISE EXTEND TO ALTERNATIVE FORMS OF MINDFUL EXERCISE, SUCH AS YOGA, TO CONFER TRANSIENT PROTECTION AGAINST NEUROVASCULAR CHALLENGES THAT INCREASE BLOOD PRESSURE (BP). OBJECTIVES: THE STUDY INTENDED TO EXAMINE THE EFFECTS OF ACUTE EXERCISE ON NEUROVASCULAR RESPONSES TO EXPOSURE OF THE FOREHEAD OF FEMALE YOGA PRACTITIONERS TO VASOCONSTRICTIVE COLD (IE, TO COLD PRESSOR STRESS). DESIGN: THE RESEARCH TEAM DESIGNED A STUDY WITH 3 CONDITIONS (IE, WITH PARTICIPANTS' PARTICIPATION IN 3 ACTIVITIES ON SEPARATE DAYS IN A REPEATED-MEASURES DESIGN). PARTICIPANTS WERE RANDOMLY ASSIGNED TO PERFORM THE ACTIVITIES IN 1 OF 3 ORDERS ACROSS SUCCESSIVE VISITS. PARTICIPANTS: PARTICIPANTS WERE 9 FEMALES, 20 TO 33 Y OLD, WHO HAD REGULARLY PRACTICED HATHA YOGA FROM 6 MO TO 12 Y BEFORE THE START OF THE STUDY. ALL PARTICIPANTS WERE NORMOTENSIVE AT ENTRY TO THE STUDY AND HAD NORMAL BODY WEIGHTS FOR THEIR HEIGHTS. INTERVENTIONS: ALL PARTICIPANTS PERFORMED 3 ACTIVITIES: (1) SELF-DIRECTED YOGA PRACTICE, THE INTERVENTION; (2) CYCLING EXERCISE AT A SELF-SELECTED INTENSITY, A POSITIVE CONTROL; AND (3) QUIET REST, A NEGATIVE CONTROL. OUTCOME MEASURES: POSTINTERVENTION, PARTICIPANTS' FOREHEADS WERE EXPOSED TO COLD. THEIR SYSTOLIC BLOOD PRESSURES (SBPS), DIASTOLIC BLOOD PRESSURES (DBPS), PULSE RATES, AND FOREARM OXYGENATION WERE ASSESSED USING NEAR-INFRARED SPECTROSCOPY. RESULTS: PARTICIPANTS' SBPS AND DBPS INCREASED DURING COLD PRESSOR STRESS UNDER ALL CONDITIONS, CONCURRENT WITH DECREASED FOREARM OXYGENATION. DURING RECOVERY FROM THE COLD, PARTICIPANTS' BPS DECLINED TO NEAR PRECOLD PRESSOR BASELINE LEVELS AFTER YOGA AND CYCLING BUT REMAINED ELEVATED AFTER QUIET REST. CONCLUSIONS: THE ENHANCED RECOVERY OF BP FROM COLD APPLIED TO THE FOREHEAD AFTER YOGA PRACTICE OR CYCLING EXERCISE SUGGESTS THAT BOTH TYPES OF EXERCISE PROMOTE A HYPOTENSIVE RESPONSE, WHICH COULD INDICATE LOWERED CARDIOVASCULAR RISK.	2018	
           
4  274  38 ADDITIONAL BENEFIT OF YOGA TO STANDARD LIFESTYLE MODIFICATION ON BLOOD PRESSURE IN PREHYPERTENSIVE SUBJECTS: A RANDOMIZED CONTROLLED STUDY. HIGH BLOOD PRESSURE (BP) IS A KNOWN RISK FACTOR FOR CARDIOVASCULAR DISEASE MORBIDITY. CONSIDERING THE GROWING EVIDENCE OF NONPHARMACOLOGICAL INTERVENTIONS IN THE MANAGEMENT OF HIGH BP, WE DESIGNED A RANDOMIZED, PARALLEL ACTIVE-CONTROLLED STUDY ON THE EFFECT OF YOGA AND STANDARD LIFESTYLE MODIFICATION (LSM) ON BP AND HEART RATE IN INDIVIDUALS WITH PREHYPERTENSION (SYSTOLIC BP 120-139 MM HG AND/OR DIASTOLIC BP 80-89 MM HG). VOLUNTEERS (20-60 YEARS) OF BOTH GENDERS WITHOUT ANY KNOWN CARDIOVASCULAR DISEASE WERE RANDOMIZED INTO EITHER LSM GROUP (N = 92) OR LSM+YOGA GROUP (N = 92). BEFORE THE INTERVENTION, AGE, WAIST CIRCUMFERENCE, PHYSICAL ACTIVITY, BP AND FASTING PLASMA GLUCOSE AND LIPIDS WERE COMPARABLE BETWEEN THE GROUPS. AFTER 12 WEEKS OF INTERVENTION, WE OBSERVED A SIGNIFICANT REDUCTION IN THE BP AND HEART RATE IN BOTH THE GROUPS. FURTHER, THE REDUCTION IN SYSTOLIC BP WAS SIGNIFICANTLY MORE IN LSM+YOGA GROUP (6 MM HG) AS COMPARED WITH LSM GROUP (4 MM HG). IN ADDITION, 13 PREHYPERTENSIVES BECAME NORMOTENSIVES IN LSM+YOGA GROUP AND FOUR IN LSM GROUP. THE RESULTS INDICATE EFFICACY OF NONPHARMACOLOGICAL INTERVENTION AND THE ADDITIONAL BENEFIT OF YOGA TO STANDARD LSM. FURTHER RESEARCH IN THIS FIELD MAY ADD TO THE LEVEL OF EVIDENCE ON THE BENEFIT OF YOGA, IN THE REDUCTION OF BP IN HIGH BP SUBJECTS, IN THE SCIENTIFIC LITERATURE.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
5  660  39 EFFECT OF 12 WEEKS OF YOGA THERAPY ON QUALITY OF LIFE AND INDIAN DIABETES RISK SCORE IN NORMOTENSIVE INDIAN YOUNG ADULT PREDIABETICS AND DIABETICS: RANDOMIZED CONTROL TRIAL. INTRODUCTION: INDIA HAS BECOME THE EPICENTRE FOR DIABETES, A STRESS-RELATED DISORDER AFFECTING THE WORKING SKILLS AND DAY-TO-DAY LIFESTYLE MANAGEMENT OF YOUNGER POPULATION. MOST OF THE STUDIES HAVE REPORTED THE EFFECT OF YOGA ON IMPROVING QUALITY OF LIFE (QOL) IN DIABETIC PATIENTS WITH OTHER COMORBIDITIES. TILL DATE, NO RANDOMIZED CONTROL TRIAL REPORTS ARE AVAILABLE TO SHOW THE EFFECT OF YOGA THERAPY ON QOL AND INDIAN DIABETES RISK SCORE (IDRS) IN NORMOTENSIVE PREDIABETIC AND DIABETIC YOUNG INDIVIDUALS. AIM: TO DETERMINE THE EFFECT OF 12 WEEKS OF YOGA THERAPY ON QOL AND IDRS AMONG NORMOTENSIVE PREDIABETIC AND DIABETIC YOUNG INDIAN ADULTS. MATERIALS AND METHODS: A RANDOMIZED CONTROL TRIAL WAS CONDUCTED IN ENDOCRINOLOGY OUTPATIENT DEPARTMENT (OPD). NORMOTENSIVE PARTICIPANTS (N=310) AGED 18-45 YEARS WERE DIVIDED INTO HEALTHY CONTROLS (N=62), PREDIABETICS (N=124) AND DIABETICS (N=124). STUDY GROUP SUBJECTS WERE RANDOMLY ASSIGNED TO GROUP II (N=62, PREDIABETES-STANDARD TREATMENT), GROUP III (N=62, PREDIABETES-STANDARD TREATMENT + YOGA THERAPY), GROUP IV (N=62, DIABETES-STANDARD TREATMENT) AND GROUP V (N=62, DIABETES-STANDARD TREATMENT + YOGA THERAPY). FLANAGAN QOL SCALE, IDRS QUESTIONNAIRE, FASTING PLASMA GLUCOSE (FPG) AND INSULIN WERE ASSESSED PRE AND POST 12 WEEKS OF INTERVENTION. STATISTICAL ANALYSIS WAS DONE USING STUDENT'S PAIRED T-TEST AND ONE-WAY ANOVA. RESULTS: PRE-POST INTERVENTION ANALYSIS SHOWED SIGNIFICANT IMPROVEMENT IN QOL SCALE WITH P<0.01 IN GROUP II AND GROUP IV; P<0.001 IN GROUP III AND GROUP V RESPECTIVELY. THERE WAS SIGNIFICANT REDUCTION IN IDRS IN GROUP II (P<0.05); P<0.001 IN GROUP III, GROUP IV AND GROUP V RESPECTIVELY. SIGNIFICANT DIFFERENCE (P<0.001) IN QOL SCALE AND IDRS WERE FOUND WHEN STUDY GROUPS WITH STANDARD TREATMENT ALONG WITH YOGA THERAPY WERE COMPARED TO STANDARD TREATMENT ALONE. CONCLUSION: YOGA THERAPY ALONG WITH STANDARD TREATMENT FOR 12 WEEKS IMPROVED QOL AND ATTENUATED THE DIABETES RISK AMONG INDIAN PREDIABETICS AND DIABETICS COMPARED TO STANDARD TREATMENT ALONE.	2017	
                  
6  967  34 EFFECTS OF AEROBIC EXERCISE TRAINING AND YOGA ON THE BAROREFLEX IN HEALTHY ELDERLY PERSONS. IT IS UNCLEAR WHETHER THE AGE-ASSOCIATED REDUCTION IN BAROREFLEX SENSITIVITY IS MODIFIABLE BY EXERCISE TRAINING. THE EFFECTS OF AEROBIC EXERCISE TRAINING AND YOGA, A NON-AEROBIC CONTROL INTERVENTION, ON THE BAROREFLEX OF ELDERLY PERSONS WAS DETERMINED. BAROREFLEX SENSITIVITY WAS QUANTIFIED BY THE ALPHA-INDEX, AT HIGH FREQUENCY (HF; 0.15-0.35 HZ, REFLECTING PARASYMPATHETIC ACTIVITY) AND MID-FREQUENCY (MF; 0.05-0.15 HZ, REFLECTING SYMPATHETIC ACTIVITY AS WELL), DERIVED FROM SPECTRAL AND CROSS-SPECTRAL ANALYSIS OF SPONTANEOUS FLUCTUATIONS IN HEART RATE AND BLOOD PRESSURE. TWENTY-SIX (10 WOMEN) SEDENTARY, HEALTHY, NORMOTENSIVE ELDERLY (MEAN 68 YEARS, RANGE 62-81 YEARS) SUBJECTS WERE STUDIED. FOURTEEN (4 WOMEN) OF THE SEDENTARY ELDERLY SUBJECTS COMPLETED 6 WEEKS OF AEROBIC TRAINING, WHILE THE OTHER 12 (6 WOMEN) SUBJECTS COMPLETED 6 WEEKS OF YOGA. HEART RATE DECREASED FOLLOWING YOGA (69 +/- 8 VS. 61 +/- 7 MIN-1, P < 0.05) BUT NOT AEROBIC TRAINING (66 +/- 8 VS. 63 +/- 9 MIN-1, P = 0.29). VO2 MAX INCREASED BY 11% FOLLOWING YOGA (P < 0.01) AND BY 24% FOLLOWING AEROBIC TRAINING (P < 0.01). NO SIGNIFICANT CHANGE IN ALPHA MF (6.5 +/- 3.5 VS. 6.2 +/- 3.0 MS MMHG-1, P = 0.69) OR ALPHA HF (8.5 +/- 4.7 VS. 8.9 +/- 3.5 MS MMHG-1, P = 0.65) OCCURRED AFTER AEROBIC TRAINING. FOLLOWING YOGA, ALPHA HF (8.0 +/- 3.6 VS. 11.5 +/- 5.2 MS MMHG-1, P < 0.01) BUT NOT ALPHA MF (6.5 +/- 3.0 VS. 7.6 +/- 2.8 MS MMHG-1, P = 0.29) INCREASED. SHORT-DURATION AEROBIC TRAINING DOES NOT MODIFY THE ALPHA-INDEX AT ALPHA MF OR ALPHA HF IN HEALTHY NORMOTENSIVE ELDERLY SUBJECTS. ALPHA HF BUT NOT ALPHA MF INCREASED FOLLOWING YOGA, SUGGESTING THAT THESE PARAMETERS ARE MEASURING DISTINCT ASPECTS OF THE BAROREFLEX THAT ARE SEPARATELY MODIFIABLE.	1997	
                                                                                                                                                                                                                                                                                                                                                                                                                       
7  758  32 EFFECT OF SLOW BREATHING ON AUTONOMIC TONE & BAROREFLEX SENSITIVITY IN YOGA PRACTITIONERS. BACKGROUND & OBJECTIVES: SLOW BREATHING INCREASES PARASYMPATHETIC ACTIVITY AND BAROREFLEX SENSITIVITY (BRS) IN HEALTHY INDIVIDUALS, ALSO SIMILARLY OBSERVED IN YOGA PRACTITIONERS. PRANAYAMA WHICH IS AN IMPORTANT COMPONENT OF YOGA WHEN PRACTICED AT A SLOW PACE WAS AT A RESPIRATORY FREQUENCY OF AROUND 0.1 HZ (6 BREATHS/MIN). THEREFORE, IT WAS HYPOTHESIZED THAT YOGA PRACTITIONERS MIGHT HAVE ADAPTED TO SLOW BREATHING. THIS STUDY WAS AIMED TO DECIPHER THE ROLE OF YOGA ON CARDIOVASCULAR VARIABILITY DURING SLOW BREATHING (0.1 HZ) IN YOGA PRACTITIONERS. METHODS: A CROSS-SECTIONAL STUDY WAS UNDERTAKEN IN NAIVE-TO-YOGA INDIVIDUALS (N=40) AND YOGA PRACTITIONERS (N=40) WITH AN AVERAGE AGE OF 31.08 +/- 7.31 AND 29.93 +/- 7.57 YR, RESPECTIVELY. THE ANALYSIS OF HEART RATE VARIABILITY, BLOOD PRESSURE VARIABILITY (BPV) AND BRS DURING SPONTANEOUS AND SLOW BREATHING WAS COMPARED BETWEEN THE TWO GROUPS. RESULTS: DURING SLOW BREATHING, THE HEART RATE (P<0.01) WAS LOWER, RESPIRATORY RATE INTERVAL (P<0.05) AND PNN50 PER CENT (P=0.01) WERE HIGHER, MEAN SYSTOLIC BP (SBP) (P<0.05) AND SDSD (STANDARD DEVIATION OF SUCCESSIVE BEAT TO BEAT SYSTOLIC BLOOD PRESSURE DIFFERENCES) (P<0.01) OF SBP VARIABILITY WERE LOWER WITH SEQUENCE BRS (P<0.001) AND ALPHA LOW FREQUENCY (P<0.01) AND ALPHA HIGH FREQUENCY (P<0.001) OF SPECTRAL BRS WERE HIGHER IN YOGA PRACTITIONERS. INTERPRETATION & CONCLUSIONS: THE PRESENT STUDY INDICATED HIGHER PARASYMPATHETIC ACTIVITY AND BRS WITH LOWER SBP VARIABILITY AT REST AND DURING SLOW BREATHING IN YOGA PRACTITIONERS COMPARED TO NAIVE GROUP. FINDINGS INDICATE THAT THE SHORT-TERM PRACTICE OF SLOW BREATHING COMPLEMENTS THE AUGMENTED PARASYMPATHETIC ACTIVITY AND BRS IN THE YOGA GROUP.	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                   
8 2213  30 THE HYPOTENSIVE EFFECT OF YOGA'S BREATHING EXERCISES: A SYSTEMATIC REVIEW. THE AIM OF THIS REVIEW WAS TO EVALUATE THE EFFECT OF PRANAYAMA (YOGA'S BREATHING EXERCISES) ON BP AND ITS APPLICABILITY IN THE TREATMENT OF HYPERTENSION. THIRTEEN TRIALS, ASSESSING ACUTE (EIGHT STUDIES) AND CHRONIC (FIVE STUDIES) BP RESPONSE TO PRANAYAMA WERE INCLUDED. SIGNIFICANT BP REDUCTIONS AFTER PRANAYAMA WERE FOUND IN BOTH ACUTE (2-10 MMHG MEAN SBP REDUCTION, N = 5 STUDIES; 1 MMHG MEAN DBP REDUCTION, N = 1 STUDY) AND CHRONIC STUDIES (4-21 MMHG MEAN SBP REDUCTION, N = 3 STUDIES; 4-7 MMHG MEAN DBP REDUCTION, N = 2 STUDIES). THE PRANAYAMA'S EFFECT ON BP WERE NOT ROBUST AGAINST SELECTION BIAS DUE TO THE LOW QUALITY OF STUDIES. BUT, THE LOWERING BP EFFECT OF PRANAYAMA IS ENCOURAGING. THE PRANAYAMA WITH SLOWER RHYTHMS AND MANIPULATION OF THE NOSTRILS, MAINLY WITH BREATHS BY THE LEFT, PRESENT BETTER RESULTS WHEN COMPARED WITH THE OTHER TYPES AND SHOULD BE THE MAIN PRANAYAMA APPLIED WHEN THE GOAL IS TO REDUCE BLOOD PRESSURE ESPECIALLY IN HYPERTENSIVE PATIENTS.	2017	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
9 1533  51 IYENGAR YOGA VERSUS ENHANCED USUAL CARE ON BLOOD PRESSURE IN PATIENTS WITH PREHYPERTENSION TO STAGE I HYPERTENSION: A RANDOMIZED CONTROLLED TRIAL. THE PREVALENCE OF PREHYPERTENSION AND STAGE 1 HYPERTENSION CONTINUES TO INCREASE DESPITE BEING AMENABLE TO NON-PHARMACOLOGIC INTERVENTIONS. IYENGAR YOGA (IY) HAS BEEN PURPORTED TO REDUCE BLOOD PRESSURE (BP) THOUGH EVIDENCE FROM RANDOMIZED TRIALS IS LACKING. WE CONDUCTED A RANDOMIZED CONTROLLED TRIAL TO ASSESS THE EFFECTS OF 12 WEEKS OF IY VERSUS ENHANCED USUAL CARE (EUC) (BASED ON INDIVIDUAL DIETARY ADJUSTMENT) ON 24-H AMBULATORY BP IN YOGA-NAIVE ADULTS WITH UNTREATED PREHYPERTENSION OR STAGE 1 HYPERTENSION. IN TOTAL, 26 AND 31 SUBJECTS IN THE IY AND EUC ARMS, RESPECTIVELY, COMPLETED THE STUDY. THERE WERE NO DIFFERENCES IN BP BETWEEN THE GROUPS AT 6 AND 12 WEEKS. IN THE EUC GROUP, 24-H SYSTOLIC BP (SBP), DIASTOLIC BP (DBP) AND MEAN ARTERIAL PRESSURE (MAP) SIGNIFICANTLY DECREASED BY 5, 3 AND 3 MMHG, RESPECTIVELY, FROM BASELINE AT 6 WEEKS (P < .05), BUT WERE NO LONGER SIGNIFICANT AT 12 WEEKS. IN THE IY GROUP, 24 H SBP WAS REDUCED BY 6 MMHG AT 12 WEEKS COMPARED TO BASELINE (P = .05). 24 H DBP (P < .01) AND MAP (P < .05) DECREASED SIGNIFICANTLY EACH BY 5 MMHG. NO DIFFERENCES WERE OBSERVED IN CATECHOLAMINE OR CORTISOL METABOLISM TO EXPLAIN THE DECREASE IN BP IN THE IY GROUP AT 12 WEEKS. TWELVE WEEKS OF IY PRODUCES CLINICALLY MEANINGFUL IMPROVEMENTS IN 24 H SBP AND DBP. LARGER STUDIES ARE NEEDED TO ESTABLISH THE LONG TERM EFFICACY, ACCEPTABILITY, UTILITY AND POTENTIAL MECHANISMS OF IY TO CONTROL BP.	2011	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
10 2759  35 YOGA PRACTITIONERS EXHIBIT HIGHER PARASYMPATHETIC ACTIVITY AND BAROREFLEX SENSITIVITY AND BETTER ADAPTABILITY TO 40 MM HG LOWER-BODY NEGATIVE PRESSURE. YOGA HAS BEEN SHOWN TO IMPROVE AUTONOMIC CONDITIONING IN HUMANS, AS EVIDENCED BY THE ENHANCEMENT OF PARASYM-PATHETIC ACTIVITY AND BAROREFLEX SENSITIVITY. THEREFORE, WE HYPOTHESIZED THAT THE EXPERIENCE OF YOGA MAY RESULT IN ADAPTATION TO ACUTE HEMODYNAMIC CHANGES. TO DECIPHER THE LONG-TERM EFFECTS OF YOGA ON CARDIOVASCULAR VARIABILITY, YOGA PRACTITIONERS WERE COMPARED TO YOGA-NAIVE SUBJECTS DURING EXPOSURE TO -40 MM HG LOWER-BODY NEGATIVE PRESSURE (LBNP). A COMPARATIVE STUDY WAS CONDUCTED ON 40 YOGANAIVE SUBJECTS AND 40 YOGA PRACTITIONERS WITH AN AVERAGE AGE OF 31.08 +/- 7.31 YEARS AND 29.93 +/- 7.57 YEARS, RESPECTIVELY. HEART RATE VARIABILITY, BLOOD PRESSURE VARIABILITY, BAROREFLEX SENSITIVITY, AND CORRELATION BETWEEN SYSTOLIC BLOOD PRESSURE AND RR INTERVAL WERE EVALUATED AT REST AND DURING LBNP. IN YOGA PRACTITIONERS, THE HEART RATE WAS LOWER IN SUPINE REST (P = 0.011) AND DURING LBNP (P = 0.043); THE PNN50 MEASURE OF HEART RATE VARIABILITY WAS HIGHER IN SUPINE REST (P = 0.011) AND DURING LBNP (P = 0.034). THE YOGA PRACTITIONERS' STANDARD DEVIATION OF SUCCESSIVE BEAT-TO-BEAT BLOOD PRESSURE INTERVALS OF SYSTOLIC BLOOD PRESSURE VARIABILITY WAS LOWER IN SUPINE REST (P = 0.034) AND DURING LBNP (P = 0.007), WITH HIGHER SEQUENCE BAROREFLEX SENSITIVITY (P = 0.019) AND ~ HIGH-FREQUENCY BAROREFLEX SENSITIVITY. MEAN SYSTOLIC BLOOD PRESSURE AND RR INTERVAL WERE INVERSELY CORRELATED IN THE YOGA GROUP (R = -0.317, P = 0.049). THE YOGA PRACTITIONERS EXHIBITED HIGHER PARASYMPATHETIC ACTIVITY AND BAROREFLEX SENSITIVITY WITH LOWER SYSTOLIC BLOOD PRESSURE VARIABILITY, INDICATING BETTER ADAPTABILITY TO LBNP COMPARED TO THE YOGA-NAIVE GROUP. OUR FINDINGS INDICATE THAT THE YOGA MODULE WAS HELPFUL IN CONDITIONS OF HYPOVOLEMIA IN HEALTHY SUBJECTS; IT IS PROPOSED TO BE BENEFICIAL IN CLINICAL CONDITIONS ASSOCIATED WITH SYMPATHETIC DOMINANCE, IMPAIRED BARORE-FLEX SENSITIVITY, AND ORTHOSTATIC INTOLERANCE.	2021	
                                                                                                                                                               
11 1322  26 HEMODYNAMIC AND PRESSOR RESPONSES TO COMBINATION OF YOGA AND BLOOD FLOW RESTRICTION. A COMBINATION OF YOGA AND BLOOD FLOW RESTRICTION, EACH OF WHICH ELICITS MARKED PRESSOR RESPONSES, MAY FURTHER INCREASE BLOOD PRESSURE AND MYOCARDIAL OXYGEN DEMAND. TO DETERMINE THE IMPACT OF A COMBINATION OF YOGA AND BLOOD FLOW RESTRICTION ON HEMODYNAMIC RESPONSES, TWENTY YOUNG HEALTHY PARTICIPANTS PERFORMED 20 YOGA POSES WITH/WITHOUT BLOOD FLOW RESTRICTION BANDS PLACED ON BOTH LEGS. AT BASELINE, THERE WERE NO SIGNIFICANT DIFFERENCES IN ANY OF THE VARIABLES BETWEEN THE BLOOD FLOW RESTRICTION AND NON-BLOOD FLOW RESTRICTION CONDITIONS. BLOOD PRESSURE AND HEART RATE INCREASED IN RESPONSE TO THE VARIOUS YOGA POSES (P<0.01) BUT WERE NOT DIFFERENT BETWEEN THE BLOOD FLOW RESTRICTION AND NON-BLOOD FLOW RESTRICTION CONDITIONS. RATE-PRESSURE PRODUCTS, AN INDEX OF MYOCARDIAL OXYGEN DEMAND, INCREASED SIGNIFICANTLY DURING YOGA EXERCISES WITH NO SIGNIFICANT DIFFERENCES BETWEEN THE TWO CONDITIONS. RATING OF PERCEIVED EXERTION WAS NOT DIFFERENT BETWEEN THE CONDITIONS. BLOOD LACTATE CONCENTRATION WAS SIGNIFICANTLY GREATER AFTER PERFORMING YOGA WITH BLOOD FLOW RESTRICTION BANDS (P=0.007). CARDIO-ANKLE VASCULAR INDEX, AN INDEX OF ARTERIAL STIFFNESS, DECREASED SIMILARLY AFTER YOGA EXERCISE IN BOTH CONDITIONS WHILE FLOW-MEDIATED DILATION REMAINED UNCHANGED. IN CONCLUSION, THE USE OF LOWER BODY BLOOD FLOW RESTRICTION BANDS IN COMBINATION WITH YOGA DID NOT RESULT IN ADDITIVE OR SYNERGISTIC HEMODYNAMIC AND PRESSOR RESPONSES.	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
12 1352  48 IMMEDIATE EFFECT OF MIND SOUND RESONANCE TECHNIQUE (MSRT - A YOGA-BASED RELAXATION TECHNIQUE) ON BLOOD PRESSURE, HEART RATE, AND STATE ANXIETY IN INDIVIDUALS WITH HYPERTENSION: A PILOT STUDY. BACKGROUND MIND SOUND RESONANCE TECHNIQUE (MSRT) IS A YOGA-BASED RELAXATION TECHNIQUE. PREVIOUS STUDIES ON MSRT DEMONSTRATED ITS POTENTIAL HEALTH-BENEFITING EFFECTS IN BOTH CLINICAL AND NONCLINICAL POPULATION. PRESENT STUDY INTENDED TO ASSESS THE ACUTE EFFECT OF MSRT INTERVENTION ON BLOOD PRESSURE, HEART RATE (HR), AND STATE ANXIETY IN PATIENTS WITH ESSENTIAL HYPERTENSION (HTN). METHODS THIRTY PARTICIPANTS (13 FEMALES) WITH HTN, WITHIN THE AGE RANGE 30-60 YEARS (WITH MEAN+/-SD: 57.23+/-11.3 YEARS), WHO VISITED SVYASA UNIVERSITY CAMPUS TO ATTEND 1-WEEK RESIDENTIAL YOGA PROGRAM FOR HTN TREATMENT, WERE CONSIDERED FOR THIS STUDY BASED ON INCLUSION AND EXCLUSION CRITERIA. ALL PARTICIPANTS RECEIVED A 4-DAY MSRT ORIENTATION SESSIONS PRIOR TO THE STUDY. EACH PARTICIPANT UNDERWENT 30-MIN SESSION OF BOTH MSRT AND SUPINE REST (SR) ON 2 SUCCESSIVE DAYS. SYSTOLIC AND DIASTOLIC BLOOD PRESSURES, PULSE RATE, AND STATE ANXIETY WERE MEASURED BEFORE AND IMMEDIATELY AFTER BOTH MSRT AND SR SESSIONS. DATA WERE ANALYZED USING SPSS VERSION 16. REPEATED-MEASURE ANALYSIS OF VARIANCE WAS APPLIED TO ASSESS WITHIN-SUBJECTS CHANGES. RESULTS AFTER MSRT SESSION, SIGNIFICANT DECREASE IN SYSTOLIC BLOOD PRESSURE (SBP), DIASTOLIC BLOOD PRESSURE (DBP), HR, AND STATE ANXIETY WAS OBSERVED COMPARED TO BASELINE. SIMILARLY, AFTER SR SESSION, SIGNIFICANT CHANGES WERE FOUND IN HR AND STATE ANXIETY. NO SIGNIFICANT CHANGE WAS SEEN IN SBP AND DBP FOLLOWING SR COMPARED TO SR SESSION; MSRT SESSION SHOWED SIGNIFICANTLY BETTER IMPROVEMENT IN SBP, DBP, HR, AND STATE ANXIETY. CONCLUSION PRESENT STUDY DEMONSTRATED THE USEFULNESS OF SINGLE SESSION OF MSRT IN REDUCING BLOOD PRESSURE, HR, AND STATE ANXIETY AMONG INDIVIDUALS WITH HTN AS COMPARED TO SR. THESE FINDINGS ENCOURAGE THE FURTHER STUDIES WITH LARGER SAMPLE SIZE AND LONG-TERM INTERVENTION WITH A ROBUST RESEARCH DESIGN.	2018	
                                                                                                                                                                                    
13 1374  39 IMPACT OF AN INTEGRATED YOGA THERAPY PROTOCOL ON INSULIN RESISTANCE AND GLYCEMIC CONTROL IN PATIENTS WITH TYPE 2 DIABETES MELLITUS. OBJECTIVE: DIABETES MELLITUS (DM), CHARACTERIZED BY CHRONIC HYPERGLYCEMIA, IS ATTRIBUTED TO RELATIVE INSULIN DEFICIENCY OR RESISTANCE, OR BOTH. STUDIES HAVE SHOWN THAT YOGA CAN MODULATE PARAMETERS OF INSULIN RESISTANCE. THE PRESENT STUDY EXPLORED THE POSSIBLE BENEFICIAL EFFECTS OF INTEGRATED YOGA THERAPY WITH REFERENCE TO GLYCEMIC CONTROL AND INSULIN RESISTANCE (IR) IN INDIVIDUALS WITH DIABETES MAINTAINED ON STANDARD ORAL MEDICAL CARE WITH YOGA THERAPY, COMPARED TO THOSE ON STANDARD ORAL MEDICAL CARE ALONE. METHODS: IN THIS STUDY, THE SUBJECTS ON YOGA INTERVENTION COMPRISED 35 TYPE 2 DIABETICS, AND AN EQUAL NUMBER OF VOLUNTEERS CONSTITUTED THE CONTROL GROUP. SUBJECTS RANGED IN AGE FROM 30 TO 70 YEARS, WITH HEMOGLOBIN A1C (HBA1C) TEST MORE THAN 7%, AND WERE MAINTAINED ON DIABETIC DIET AND ORAL HYPOGLYCEMIC AGENTS. BLOOD SAMPLES WERE DRAWN PRIOR TO AND AFTER 120 DAYS OF INTEGRATED YOGA THERAPY INTERVENTION. FASTING BLOOD GLUCOSE (FBG), POST-PRANDIAL BLOOD GLUCOSE (PPBG), HBA1C, INSULIN, AND LIPID PROFILE WERE ASSESSED IN BOTH THE INTERVENTION AND CONTROL GROUPS. RESULTS: THE INTERVENTION GROUP REVEALED SIGNIFICANT IMPROVEMENTS IN BODY MASS INDEX (BMI) (0.7 KG/M(2) MEDIAN DECREASE; P=0.001), FBG (20 MG/DL MEDIAN DECREASE; P<0.001), PPBG (33 MG/DL MEDIAN DECREASE; P<0.001), HBA1C (0.4% MEDIAN DECREASE; P<0.001), HOMEOSTATIC MODEL ASSESSMENT FOR INSULIN RESISTANCE (HOMA-IR) (1.2 MEDIAN DECREASE; P<0.001), CHOLESTEROL (13 MG/DL MEDIAN DECREASE, P=0.006), TRIACYLGLYCEROL (22 MG/DL MEDIAN DECREASE; P=0.027), LOW-DENSITY LIPOPROTEIN (6 MG/DL MEDIAN DECREASE; P=0.004), AND VERY-LOW-DENSITY LIPOPROTEIN LEVELS (4 MG/DL MEDIAN DECREASE; P=0.032). INCREASES IN HIGH-DENSITY LIPOPROTEIN AFTER 120 DAYS WERE NOT SIGNIFICANT (6 MG/DL MEDIAN INCREASE; P=0.15). HOWEVER, WHEN COMPARED TO CHANGES OBSERVED IN PATIENTS IN THE CONTROL GROUP, ALL THESE IMPROVEMENTS PROVED TO BE SIGNIFICANT. CONCLUSION: ADMINISTRATION OF INTEGRATED YOGA THERAPY TO INDIVIDUALS WITH DIABETES LEADS TO A SIGNIFICANT IMPROVEMENT IN GLYCEMIC CONTROL, INSULIN RESISTANCE, AND KEY BIOCHEMICAL PARAMETERS.	2022	
    
14 2715  39 YOGA LIFESTYLE INTERVENTION REDUCES BLOOD PRESSURE IN HIV-INFECTED ADULTS WITH CARDIOVASCULAR DISEASE RISK FACTORS. OBJECTIVE: PEOPLE LIVING WITH HIV INFECTION ARE AT INCREASED RISK FOR DEVELOPING CARDIOVASCULAR DISEASE (CVD). SAFE AND EFFECTIVE INTERVENTIONS FOR LOWERING CVD RISK IN HIV INFECTION ARE HIGH PRIORITIES. WE CONDUCTED A PROSPECTIVE, RANDOMIZED, CONTROLLED STUDY TO EVALUATE WHETHER A YOGA LIFESTYLE INTERVENTION IMPROVES CVD RISK FACTORS, VIROLOGICAL OR IMMUNOLOGICAL STATUS, OR QUALITY OF LIFE (QOL) IN HIV-INFECTED ADULTS RELATIVE TO STANDARD OF CARE TREATMENT IN A MATCHED CONTROL GROUP. METHODS: SIXTY HIV-INFECTED ADULTS WITH MILD-MODERATE CVD RISK WERE ASSIGNED TO 20 WEEKS OF SUPERVISED YOGA PRACTICE OR STANDARD OF CARE TREATMENT. BASELINE AND WEEK 20 MEASURES WERE: 2-H ORAL GLUCOSE TOLERANCE TEST WITH INSULIN MONITORING, BODY COMPOSITION, FASTING SERUM LIPID/LIPOPROTEIN PROFILE, RESTING BLOOD PRESSURES, CD4 T-CELL COUNT AND PLASMA HIV RNA, AND THE MEDICAL OUTCOMES STUDY SHORT FORM (SF)-36 HEALTH-RELATED QOL INVENTORY. RESULTS: RESTING SYSTOLIC AND DIASTOLIC BLOOD PRESSURES IMPROVED MORE (P=0.04) IN THE YOGA GROUP (-5 +/- 2 AND -3 +/- 1 MMHG, RESPECTIVELY) THAN IN THE STANDARD OF CARE GROUP (+1 +/- 2 AND+2 +/- 2 MMHG, RESPECTIVELY). HOWEVER, THERE WAS NO GREATER REDUCTION IN BODY WEIGHT, FAT MASS OR PROATHEROGENIC LIPIDS, OR IMPROVEMENTS IN GLUCOSE TOLERANCE OR OVERALL QOL AFTER YOGA. IMMUNE AND VIROLOGICAL STATUS WAS NOT ADVERSELY AFFECTED. CONCLUSION: AMONG TRADITIONAL LIFESTYLE MODIFICATIONS, YOGA IS A LOW-COST, SIMPLE TO ADMINISTER, NONPHARMACOLOGICAL, POPULAR BEHAVIOURAL INTERVENTION THAT CAN LOWER BLOOD PRESSURE IN PRE-HYPERTENSIVE HIV-INFECTED ADULTS WITH MILD-MODERATE CVD RISK FACTORS.	2010	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
15 2153  27 THE EFFECTS OF SUDARSHAN KRIYA YOGA ON SOME PHYSIOLOGICAL AND BIOCHEMICAL PARAMETERS IN MILD HYPERTENSIVE PATIENTS. AN OPEN LABEL INTERVENTION STUDY WAS UNDERTAKEN ON 26 MILD HYPERTENSIVES AND 26 APPARENTLY HEALTHY ADULTS (30-60 Y), FOR THE EFFECT OF SUDARSHAN KRIYA YOGA PRACTICE FOR TWO MONTHS AS COMPLEMENTARY THERAPY. IN THE HYPERTENSIVES, THERE WAS A SIGNIFICANT DECREASE IN DIASTOLIC BLOOD PRESSURE (P < 0.01), SERUM UREA (P < 0.01) AND PLASMA MDA (MALONDIALDEHYDE ADDUCTS) AS OXIDATIVE STRESS MARKER (P < 0.05). OTHER PARAMETERS; VIZ.; PLASMA LEVELS OF CHOLESTEROL, TRIGLYCERIDES, GLUCOSE, DID NOT CHANGE SIGNIFICANTLY (P > 0.1). THE PATTERN OF CHANGE IN MOST OF THE STUDY PARAMETERS WAS SUCH THAT VALUES ABOVE NORMAL RANGE WERE LOWERED BUT VALUES WITHIN NORMAL RANGE WERE UNALTERED. THE ACTION OF YOGA ON DIASTOLIC BLOOD PRESSURE, MALONDIALDEHYDE ADDUCTS AND KIDNEY FUNCTION IN HYPERTENSIVES WAS OF COUNTERACTIVE NATURE AND FELT TO BE DISTINCTLY DIFFERENT THAN THE EFFECT OF DRUGS.	2011	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
16  411  35 BLOOD PRESSURE AND HEART RATE VARIABILITY DURING YOGA-BASED ALTERNATE NOSTRIL BREATHING PRACTICE AND BREATH AWARENESS. BACKGROUND: PREVIOUS RESEARCH HAS SHOWN A REDUCTION IN BLOOD PRESSURE (BP) IMMEDIATELY AFTER THE PRACTICE OF ALTERNATE NOSTRIL YOGA BREATHING (ANYB) IN NORMAL HEALTHY MALE VOLUNTEERS AND IN HYPERTENSIVE PATIENTS OF BOTH SEXES. THE BP DURING ANYB HAS NOT BEEN RECORDED. MATERIAL/METHODS: PARTICIPANTS WERE 26 MALE VOLUNTEERS (GROUP MEAN AGE +/-SD, 23.8+/-3.5 YEARS). WE ASSESSED (1) HEART RATE VARIABILITY, (2) NON-INVASIVE ARTERIAL BP, AND (3) RESPIRATION RATE, DURING (A) ANYB AND (B) BREATH AWARENESS (BAW) SESSIONS. EACH SESSION WAS 25 MINUTES. WE PERFORMED ASSESSMENTS AT 3 TIME POINTS: PRE (5 MINUTES), DURING (15 MINUTES; FOR ANYB OR BAW) AND POST (5 MINUTES). A NAIVE-TO-YOGA CONTROL GROUP (N=15 MALES, MEAN AGE +/-SD 26.1+/-4.0 YEARS) WERE ASSESSED WHILE SEATED QUIETLY FOR 25 MINUTES. RESULTS: DURING ANYB THERE WAS A SIGNIFICANT DECREASE (REPEATED MEASURES ANOVA) IN SYSTOLIC BP AND RESPIRATION RATE; WHILE RMSSD (THE SQUARE ROOT OF THE MEAN OF THE SUM OF SQUARES OF DIFFERENCES BETWEEN ADJACENT NN INTERVALS) AND NN50 (THE NUMBER OF INTERVAL DIFFERENCES OF SUCCESSIVE NORMAL TO NORMAL INTERVALS GREATER THAN 50 MS) SIGNIFICANTLY INCREASED. DURING BAW RESPIRATION RATE DECREASED. IN CONTRAST, RESPIRATION RATE INCREASED DURING THE CONTROL STATE. ANYB AND BAW WERE SIGNIFICANTLY DIFFERENT (2-FACTOR ANOVA) IN RMSSD AND RESPIRATION RATE. BAW AND CONTROL WERE DIFFERENT WITH RESPECT TO RESPIRATION RATE. CONCLUSIONS: THE RESULTS SUGGEST THAT VAGAL ACTIVITY INCREASED DURING AND AFTER ANYB, WHICH COULD HAVE CONTRIBUTED TO THE DECREASE IN BP AND CHANGES IN THE HRV.	2014	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
17  812  34 EFFECT OF YOGA ON CARDIAC AUTONOMIC DYSFUNCTION AND INSULIN RESISTANCE IN NON-DIABETIC OFFSPRING OF TYPE-2-DIABETES PARENTS: A RANDOMIZED CONTROLLED STUDY. OBJECTIVE: THE PRESENT STUDY WAS AIMED TO DETERMINE THE EFFECT OF YOGA PROGRAM ON CARDIAC AUTONOMIC DYSFUNCTION AND INSULIN RESISTANCE IN NON-DIABETIC OFFSPRING OF DIABETES PARENTS. METHODS: A RANDOMIZED PASSIVE-CONTROLLED STUDY WAS CONDUCTED ON 64 NON-DIABETIC OFFSPRING OF TYPE-2-DIABETES PARENTS (MEAN-AGE:25.17YEARS). YOGA GROUP PARTICIPANTS RECEIVED YOGA TRAINING FOR 8 WEEKS. HEART-RATE VARIABILITY (HRV) INDICES: LOW FREQUENCY (LF), HIGH FREQUENCY (HF) AND LF/HF RATIO; FASTING BLOOD GLUCOSE (FBG), ORAL GLUCOSE TOLERANCE TEST (OGTT) AND INSULIN RESISTANCE (IR) WERE ESTIMATED AT BASELINE AND AFTER 8-WEEKS OF INTERVENTION. RESULTS: WE FOUND A SIGNIFICANT DECREASE IN LF (P=0.005), LF/HF RATIO (P=0.004), IR (P<0.001), OGTT (P=0.003) AND INCREASE IN HF (P=0.022) IN YOGA GROUP PARTICIPANTS. CONTROL GROUP PARTICIPANTS DID NOT SHOW ANY SIGNIFICANT CHANGE IN ANY VARIABLES. CONCLUSIONS: IMPROVEMENT IN CARDIAC AUTONOMIC FUNCTION AND INSULIN RESISTANCE BY YOGA TRAINING IMPLIES THAT YOGA CAN REDUCE THE RISK OF DEVELOPMENT OF DIABETES IN OFFSPRING OF DIABETES PARENTS.	2019	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
18  938  47 EFFECTS OF 1-YEAR YOGA ON CARDIOVASCULAR RISK FACTORS IN MIDDLE-AGED AND OLDER ADULTS WITH METABOLIC SYNDROME: A RANDOMIZED TRIAL. BACKGROUND: METABOLIC SYNDROME (METS) IS A CLUSTERING OF CARDIOVASCULAR RISK FACTORS, WHICH IS ASSOCIATED WITH DIABETES MELLITUS AND CARDIOVASCULAR DISEASE. LIFESTYLE INTERVENTIONS APPLIED TO PEOPLE WITH METS HAS CONSIDERABLE BENEFICIAL EFFECTS ON DISEASE PREVENTIVE OUTCOMES. THIS STUDY AIMED TO EXAMINE THE EFFECTS OF 1-YEAR OF YOGA EXERCISE ON THE CARDIOVASCULAR RISK FACTORS INCLUDING CENTRAL OBESITY, HYPERTENSION, DYSLIPIDEMIA AND HYPERGLYCEMIA IN MIDDLE-AGED AND OLDER HONG KONG CHINESE ADULTS WITH METS. METHODS: ADULTS DIAGNOSED WITH METS USING NATIONAL CHOLESTEROL EDUCATION PROGRAM CRITERIA (N = 182; MEAN +/- SD AGE = 56 +/- 9.1) WERE RANDOMLY ASSIGNED TO A 1-YEAR YOGA INTERVENTION GROUP OR CONTROL GROUP. SYSTOLIC AND DIASTOLIC BLOOD PRESSURE, WAIST CIRCUMFERENCE, FASTING PLASMA GLUCOSE, TRIGLYCERIDES, AND HIGH-DENSITY LIPOPROTEIN CHOLESTEROL WERE EXAMINED AT BASELINE, MIDWAY, AND ON COMPLETION OF THE STUDY. PHYSICAL ACTIVITY LEVEL AND CALORIC INTAKE WERE ASSESSED AND INCLUDED IN THE COVARIATE ANALYSES. RESULTS: A REDUCTION OF THE NUMBER OF DIAGNOSTIC COMPONENTS FOR METS WAS FOUND TO BE ASSOCIATED WITH THE YOGA INTERVENTION. WAIST CIRCUMFERENCE WAS SIGNIFICANTLY IMPROVED AFTER THE 1-YEAR YOGA INTERVENTION. A TREND TOWARDS A DECREASE IN SYSTOLIC BLOOD PRESSURE WAS OBSERVED FOLLOWING YOGA INTERVENTION. CONCLUSION: THESE RESULTS SUGGEST THAT YOGA EXERCISE IMPROVES THE CARDIOVASCULAR RISK FACTORS INCLUDING CENTRAL OBESITY AND BLOOD PRESSURE IN MIDDLE-AGED AND OLDER ADULTS WITH METS. THESE FINDINGS SUPPORT THE COMPLEMENTARY BENEFICIAL ROLE OF YOGA IN MANAGING METS.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
19  658  43 EFFECT OF 1-WEEK YOGA-BASED RESIDENTIAL PROGRAM ON CARDIOVASCULAR VARIABLES OF HYPERTENSIVE PATIENTS: A COMPARATIVE STUDY. INTRODUCTION: HYPERTENSION (HTN) IS AN IMPORTANT PUBLIC HEALTH CONCERN AND A LEADING CAUSE OF MORBIDITY AND MORTALITY WORLDWIDE. YOGA IS A FORM OF MIND-BODY MEDICINE SHOWN TO BE EFFECTIVE IN CONTROLLING BLOOD PRESSURE (BP) AND REDUCES CARDIAC RISK FACTORS IN HTN. INTEGRATED APPROACH OF YOGA THERAPY (IAYT) IS A RESIDENTIAL YOGA-BASED LIFESTYLE INTERVENTION PROVEN TO BE BENEFICIAL IN SEVERAL HEALTH CONDITIONS. AIM: TO STUDY THE EFFICACY OF 1 WEEK OF RESIDENTIAL IAYT INTERVENTION ON CARDIOVASCULAR PARAMETERS IN HYPERTENSIVE PATIENTS. METHODOLOGY: TWENTY HYPERTENSIVE INDIVIDUALS (7 FEMALES) WITHIN AGE RANGE BETWEEN 30 AND 60 YEARS (AVERAGE; 46.62 +/- 9.9 YEARS), WHO UNDERWENT 1 WEEK OF IAYT TREATMENT FOR HTN, WERE COMPARED WITH AGE- GENDER-MATCHED NON-IAYT GROUP (5 FEMALES; AVERAGE AGE; 47.08 +/- 9.69 YEARS) IN TERMS OF SYSTOLIC BP (SBP), DIASTOLIC BP (DBP), MEAN ARTERIAL PRESSURE (MAP), CARDIAC OUTPUT (CO), STROKE VOLUME (SV), BAROREFLEX SENSITIVITY (BRS), AND TOTAL PERIPHERAL VASCULAR RESISTANCE (TPVR), IAYT PROGRAM CONSISTED OF SESSIONS OF ASANAS, BREATHING PRACTICES, MEDITATION AND RELAXATION TECHNIQUES, LOW SALT, LOW-CALORIE DIET, DEVOTIONAL SESSION, AND COUNSELING. INDIVIDUALS IN NON-IAYT GROUP FOLLOWED THEIR NORMAL ROUTINE. ALL THE VARIABLES WERE ASSESSED BEFORE AND AFTER ONE WEEK. DATA WERE ANALYZED USING SPSS VERSION 16. RM-ANOVA WAS APPLIED TO ASSESS WITHIN GROUP AND BETWEEN GROUP CHANGES AFTER INTERVENTION. RESULTS: THERE WAS A SIGNIFICANT IMPROVEMENT IN SBP (P = 0.004), DBP (P = 0.008), MAP (0.03), BRS (P < 0.001), AND TPVR (P = 0.007) IN IAYT, GROUP WHEREAS IN CONTROL GROUP, WE DID NOT FIND SIGNIFICANT DIFFERENCE IN ANY OF THE VARIABLES. BETWEEN-GROUP COMPARISON SHOWED A SIGNIFICANT IMPROVEMENT IN SBP (P = 0.038), BRS (P = 0.034), AND TPVR (P = 0.015) IN IAYT GROUP AS COMPARED TO NON-IAYT GROUP. CONCLUSION: ONE-WEEK IAYT INTERVENTION SHOWED AN IMPROVEMENT IN BAROREFLEX SENSITIVITY, SYSTOLIC BP, AND TOTAL PERIPHERAL VASCULAR RESISTANCE IN HYPERTENSIVE PATIENTS. HOWEVER, FURTHER RANDOMIZED CONTROL TRIALS NEED TO BE PERFORMED TO CONFIRM THE PRESENT FINDINGS.	2018	

20 2491  43 YOGA AS ANTIHYPERTENSIVE LIFESTYLE THERAPY: A SYSTEMATIC REVIEW AND META-ANALYSIS. OBJECTIVE: TO INVESTIGATE THE EFFICACY OF YOGA AS ANTIHYPERTENSIVE LIFESTYLE THERAPY AND IDENTIFY MODERATORS THAT ACCOUNT FOR VARIABILITY IN THE BLOOD PRESSURE (BP) RESPONSE TO YOGA. METHODS: WE SYSTEMATICALLY SEARCHED 6 ELECTRONIC DATABASES FROM INCEPTION THROUGH JUNE 4, 2018, FOR ARTICLES PUBLISHED IN ENGLISH LANGUAGE JOURNALS ON TRIALS OF YOGA INTERVENTIONS THAT INVOLVED ADULT PARTICIPANTS, REPORTED PREINTERVENTION AND POSTINTERVENTION BP, AND HAD A NONEXERCISE/NONDIET CONTROL GROUP. OUR SEARCH YIELDED 49 QUALIFYING CONTROLLED TRIALS (56 INTERVENTIONS). WE (1) EVALUATED THE RISK OF BIAS AND METHODOLOGICAL STUDY QUALITY, (2) PERFORMED META-REGRESSION ANALYSIS FOLLOWING RANDOM-EFFECTS ASSUMPTIONS, AND (3) GENERATED ADDITIVE MODELS THAT REPRESENTED THE LARGEST POSSIBLE CLINICALLY RELEVANT BP REDUCTIONS. RESULTS: ON AVERAGE, THE 3517 TRIAL PARTICIPANTS WERE MIDDLE-AGED (49.2+/-19.5 YEARS), OVERWEIGHT (27.9+/-3.6 KG/M(2)) ADULTS WITH HIGH BP (SYSTOLIC BP, 129.3+/-13.3 MM HG; DIASTOLIC BP, 80.7+/-8.4 MM HG). YOGA WAS PRACTICED 4.8+/-3.4 SESSIONS PER WEEK FOR 59.2+/-25.0 MINUTES PER SESSION FOR 13.2+/-7.5 WEEKS. ON AVERAGE, YOGA ELICITED MODERATE REDUCTIONS IN SYSTOLIC BP (WEIGHTED MEAN EFFECT SIZE, -0.47; 95% CI, -0.62-0.32, -5.0 MM HG) AND DIASTOLIC BP (WEIGHTED MEAN EFFECT SIZE, -0.47; 95% CI, -0.61 TO -0.32; -3.9 MM HG) COMPARED WITH CONTROLS (P<.001 FOR BOTH SYSTOLIC BP AND DIASTOLIC BP). CONTROLLING FOR PUBLICATION BIAS AND METHODOLOGICAL STUDY QUALITY, WHEN YOGA WAS PRACTICED 3 SESSIONS PER WEEK AMONG SAMPLES WITH HYPERTENSION, YOGA INTERVENTIONS THAT INCLUDED BREATHING TECHNIQUES AND MEDITATION/MENTAL RELAXATION ELICITED BP REDUCTIONS OF 11/6 MM HG COMPARED WITH THOSE THAT DID NOT (IE, 6/3 MM HG). CONCLUSION: OUR RESULTS INDICATE THAT YOGA IS A VIABLE ANTIHYPERTENSIVE LIFESTYLE THERAPY THAT PRODUCES THE GREATEST BP BENEFITS WHEN BREATHING TECHNIQUES AND MEDITATION/MENTAL RELAXATION ARE INCLUDED.	2019