1 2907 102 [ON THE METHODOLOGICAL APPROACH TO THE ELUCIDATION OF MECHANISMS UNDERLYING THERAPEUTIC EFFECTIVENESS OF CIGUN, INDIAN AND TIBETAN YOGA THERAPY]. THE METHODOLOGICAL APPROACH IS PROPOSED ALLOWING TO OBJECTIVELY CHARACTERIZE NEUROPHYSIOLOGICAL MECHANISMS UNDERLYING THERAPEUTIC EFFECTIVENESS OF CIGUN, INDIAN AND TIBETAN YOGA THERAPY. EXECUTION OF EXERCISES STIPULATED IN THESE PROGRAMS IS INTERPRETED AS A CONSCIOUSNESS-INSPIRED SPECIFIC FORM OF HUMAN BEHAVIOUR (ACTIVITY). STEP-BY-STEP ANALYSIS OF MENTALLY-ORGANIZED BODY'S FUNCTIONAL SYSTEMS AS A NEUROPHYSIOLOGICAL BASIS OF REALIZABLE BEHAVIOUR IS PRESENTED. OPERATIONAL INTERPRETATION OF INTERNAL MECHANISMS UNDERLYING THE SYSTEM'S FUNCTIONING PERMITS TO EVALUATE THE STEREOTYPE BRAIN CONDITION ACTUALIZED BY SPECIFIC REQUIREMENTS AND MOTIVATIONS THAT INITIATES SENSORY DEPRIVATION TO ENSURE PRIORITY REALIZATION OF INTERNAL GENETICALLY DETERMINED ACTIVITY OF THE HUMAN BODY. MOBILIZATION OF THIS INTERNAL ACTIVITY IS DESCRIBED AS A PROCESS OF SELECTIVE FORMATION OF MANY COMPLICATED INTERACTIONS BETWEEN VARIOUS STRUCTURES OF THE RETICULAR FORMATION, LIMBIC SYSTEM, SUBCORTICAL CENTRES, AND NEOCORTEX MAINTAINING PRIORITY FUNCTIONING OF HOMEOSTATIC MECHANISMS OF SELF-REGULATION AND INBORN HUMAN BEHAVIOUR. THESE MECHANISMS ARE BELIEVED TO UNDERLIE THE AUTORECONSTRUCTIVE POTENTIAL OF HUMAN ORGANISM BY ENSURING SYSTEMIC CORRECTION AND RESTORATION OF ITS FUNCTIONAL RESOURCES. 2010 2 1669 18 NEUROPHYSIOLOGICAL AND NEUROCOGNITIVE MECHANISMS UNDERLYING THE EFFECTS OF YOGA-BASED PRACTICES: TOWARDS A COMPREHENSIVE THEORETICAL FRAMEWORK. DURING RECENT DECADES NUMEROUS YOGA-BASED PRACTICES (YBP) HAVE EMERGED IN THE WEST, WITH THEIR AIMS RANGING FROM FITNESS GAINS TO THERAPEUTIC BENEFITS AND SPIRITUAL DEVELOPMENT. YOGA IS ALSO BEGINNING TO SPARK GROWING INTEREST WITHIN THE SCIENTIFIC COMMUNITY, AND YOGA-BASED INTERVENTIONS HAVE BEEN ASSOCIATED WITH MEASUREABLE CHANGES IN PHYSIOLOGICAL PARAMETERS, PERCEIVED EMOTIONAL STATES, AND COGNITIVE FUNCTIONING. YBP TYPICALLY INVOLVE A COMBINATION OF POSTURES OR MOVEMENT SEQUENCES, CONSCIOUS REGULATION OF THE BREATH, AND VARIOUS TECHNIQUES TO IMPROVE ATTENTIONAL FOCUS. HOWEVER, SO FAR LITTLE IF ANY RESEARCH HAS ATTEMPTED TO DECONSTRUCT THE ROLE OF THESE DIFFERENT COMPONENT PARTS IN ORDER TO BETTER UNDERSTAND THEIR RESPECTIVE CONTRIBUTION TO THE EFFECTS OF YBP. A CLEAR OPERATIONAL DEFINITION OF YOGA-BASED THERAPEUTIC INTERVENTIONS FOR SCIENTIFIC PURPOSES, AS WELL AS A COMPREHENSIVE THEORETICAL FRAMEWORK FROM WHICH TESTABLE HYPOTHESES CAN BE FORMULATED, IS THEREFORE NEEDED. HERE WE PROPOSE SUCH A FRAMEWORK, AND OUTLINE THE BOTTOM-UP NEUROPHYSIOLOGICAL AND TOP-DOWN NEUROCOGNITIVE MECHANISMS HYPOTHESIZED TO BE AT PLAY IN YBP. 2015 3 2724 11 YOGA NEUROPATHY. A SNOOZER. SCIATIC NERVE COMPRESSION VERY RARELY OCCURS BILATERALLY. THE AUTHORS PRESENT A WOMAN WITH PROFOUND LOWER EXTREMITY WEAKNESS AND SENSORY ABNORMALITY AFTER FALLING ASLEEP IN THE HEAD-TO-KNEES YOGA POSITION (ALSO CALLED "PASCHIMOTTANASANA"). CLINICAL AND ELECTRODIAGNOSTIC FINDINGS ARE DISCUSSED IN DETAIL AND A BRIEF REVIEW OF THE LITERATURE IS PRESENTED. 2005 4 422 24 BRIDGING THE SCHISM OF SCHIZOPHRENIA THROUGH YOGA-REVIEW OF PUTATIVE MECHANISMS. SCHIZOPHRENIA PATIENTS EXPERIENCE A 'DISCONNECT' AT MULTIPLE LEVELS-NEURONAL NETWORKS, MENTAL PROCESSES, AND INTERPERSONAL RELATIONSHIPS. THE RESULTANT POOR QUALITY-OF-LIFE AND FUNCTIONAL DISABILITY ARE RELATED TO THE PERSISTENT COGNITIVE DEFICITS AND NEGATIVE SYMPTOMS, WHICH ARE RATHER RESISTANT TO CONVENTIONAL ANTIPSYCHOTIC MEDICATIONS. YOGA HAS EMERGED AS AN IMPORTANT THERAPEUTIC INTERVENTION TO IMPROVE QUALITY-OF-LIFE IN SCHIZOPHRENIA. RECENT PRELIMINARY EVIDENCE SUGGESTS THAT EFFECTS OF YOGA ON COGNITIVE AND NEGATIVE SYMPTOMS MAY DRIVE THIS BENEFIT. THIS STUDY ATTEMPTS TO INTEGRATE EVIDENCE FROM NEUROSCIENCE-BASED RESEARCH, WHICH FOCUSES ON THE NEUROPLASTICITY-HARNESSING EFFECTS OF YOGA TO BRIDGE THE SCHIZOPHRENIA CONNECTOPATHY. IN AN OVERARCHING MODEL TO STUDY PUTATIVE NEUROBIOLOGICAL MECHANISMS THAT DRIVE THERAPEUTIC EFFECTS OF YOGA, IT IS PROPOSED THAT (A) VARIOUS STYLES OF MEDITATION MAY HELP IN STRENGTHENING THE LATERAL AND MEDIAL PREFRONTAL BRAIN NETWORKS, THUS IMPROVING NEUROCOGNITION AND MENTALIZING ABILITIES, AND (B) LEARNING AND PERFORMING CO-ORDINATED PHYSICAL POSTURES WITH A TEACHER FACILITATES IMITATION AND THE PROCESS OF BEING IMITATED, WHICH CAN IMPROVE SOCIAL COGNITION AND EMPATHY THROUGH REINFORCEMENT OF THE PREMOTOR AND PARIETAL MIRROR NEURON SYSTEM. OXYTOCIN MAY PLAY A ROLE IN MEDIATING THESE PROCESSES, LEADING TO BETTER SOCIAL CONNECTEDNESS AND SOCIAL OUTCOMES. CLINICAL AND HEURISTIC IMPLICATIONS OF THIS MODEL ARE FURTHER DISCUSSED. 2016 5 1347 28 HYPOXIA IN CNS PATHOLOGIES: EMERGING ROLE OF MIRNA-BASED NEUROTHERAPEUTICS AND YOGA BASED ALTERNATIVE THERAPIES. CELLULAR RESPIRATION IS A VITAL PROCESS FOR THE EXISTENCE OF LIFE. ANY CONDITION THAT RESULTS IN DEPRIVATION OF OXYGEN (ALSO TERMED AS HYPOXIA) MAY EVENTUALLY LEAD TO DELETERIOUS EFFECTS ON THE FUNCTIONING OF TISSUES. BRAIN BEING THE HIGHEST CONSUMER OF OXYGEN IS PRONE TO INCREASED RISK OF HYPOXIA-INDUCED NEUROLOGICAL INSULTS. THIS IN TURN HAS BEEN ASSOCIATED WITH MANY DISEASES OF CENTRAL NERVOUS SYSTEM (CNS) SUCH AS STROKE, ALZHEIMER'S, ENCEPHALOPATHY ETC. ALTHOUGH SEVERAL STUDIES HAVE INVESTIGATED THE PATHOPHYSIOLOGICAL MECHANISMS UNDERLYING ISCHEMIC/HYPOXIC CNS DISEASES, THE KNOWLEDGE ABOUT PROTECTIVE THERAPEUTIC STRATEGIES TO AMELIORATE THE AFFECTED NEURONAL CELLS IS MEAGER. THIS HAS AUGMENTED THE NEED TO IMPROVE OUR UNDERSTANDING OF THE HYPOXIC AND ISCHEMIC EVENTS OCCURRING IN THE BRAIN AND IDENTIFY NOVEL AND ALTERNATE TREATMENT MODALITIES FOR SUCH INSULTS. MICRORNA (MIRNAS), SMALL NON-CODING RNA MOLECULES, HAVE RECENTLY EMERGED AS POTENTIAL NEUROPROTECTIVE AGENTS AS WELL AS TARGETS, UNDER HYPOXIC CONDITIONS. THESE 18-22 NUCLEOTIDE LONG RNA MOLECULES ARE PROFUSELY PRESENT IN BRAIN AND OTHER ORGANS AND FUNCTION AS GENE REGULATORS BY CLEAVING AND SILENCING THE GENE EXPRESSION. IN BRAIN, THESE ARE KNOWN TO BE INVOLVED IN NEURONAL DIFFERENTIATION AND PLASTICITY. THEREFORE, TARGETING MIRNA EXPRESSION REPRESENTS A NOVEL THERAPEUTIC APPROACH TO INTERCEDE AGAINST HYPOXIC AND ISCHEMIC BRAIN INJURY. IN THE FIRST PART OF THIS REVIEW, WE WILL DISCUSS THE NEUROPHYSIOLOGICAL CHANGES CAUSED AS A RESULT OF HYPOXIA, FOLLOWED BY THE CONTRIBUTION OF HYPOXIA IN THE NEURODEGENERATIVE DISEASES. SECONDLY, WE WILL PROVIDE RECENT UPDATES AND INSIGHTS INTO THE ROLES OF MIRNA IN THE REGULATION OF GENES IN OXYGEN AND GLUCOSE DEPRIVED BRAIN IN ASSOCIATION WITH CIRCADIAN RHYTHMS AND HOW THESE CAN BE TARGETED AS NEUROPROTECTIVE AGENTS FOR CNS INJURIES. FINALLY, WE WILL EMPHASIZE ON ALTERNATE BREATHING OR YOGIC INTERVENTIONS TO OVERCOME THE HYPOXIA ASSOCIATED ANOMALIES THAT COULD ULTIMATELY LEAD TO IMPROVEMENT IN CEREBRAL PERFUSION. 2017 6 1639 21 MODULATION OF IMMUNE RESPONSES IN STRESS BY YOGA. STRESS IS A CONSTANT FACTOR IN TODAY'S FASTPACED LIFE THAT CAN JEOPARDIZE OUR HEALTH IF LEFT UNCHECKED. IT IS ONLY IN THE LAST HALF CENTURY THAT THE ROLE OF STRESS IN EVERY AILMENT FROM THE COMMON COLD TO AIDS HAS BEEN EMPHASIZED, AND THE MECHANISMS INVOLVED IN THIS PROCESS HAVE BEEN STUDIED. STRESS INFLUENCES THE IMMUNE RESPONSE PRESUMABLY THROUGH THE ACTIVATION OF THE HYPOTHALAMIC-PITUITARY ADRENAL AXIS, HYPOTHALAMIC PITUITARY-GONADAL AXIS, AND THE SYMPATHETIC-ADRENAL-MEDULLARY SYSTEM. VARIOUS NEUROTRANSMITTERS, NEUROPEPTIDES, HORMONES, AND CYTOKINES MEDIATE THESE COMPLEX BIDIRECTIONAL INTERACTIONS BETWEEN THE CENTRAL NERVOUS SYSTEM (CNS) AND THE IMMUNE SYSTEM. THE EFFECTS OF STRESS ON THE IMMUNE RESPONSES RESULT IN ALTERATIONS IN THE NUMBER OF IMMUNE CELLS AND CYTOKINE DYSREGULATION. VARIOUS STRESS MANAGEMENT STRATEGIES SUCH AS MEDITATION, YOGA, HYPNOSIS, AND MUSCLE RELAXATION HAVE BEEN SHOWN TO REDUCE THE PSYCHOLOGICAL AND PHYSIOLOGICAL EFFECTS OF STRESS IN CANCERS AND HIV INFECTION. THIS REVIEW AIMS TO DISCUSS THE EFFECT OF STRESS ON THE IMMUNE SYSTEM AND EXAMINE HOW RELAXATION TECHNIQUES SUCH AS YOGA AND MEDITATION COULD REGULATE THE CYTOKINE LEVELS AND HENCE, THE IMMUNE RESPONSES DURING STRESS. 2008 7 2886 22 YOGA: BALANCING THE EXCITATION-INHIBITION EQUILIBRIUM IN PSYCHIATRIC DISORDERS. SOCIAL BEHAVIORAL DISTURBANCES ARE CENTRAL TO MOST PSYCHIATRIC DISORDERS. A DISEQUILIBRIUM WITHIN THE CORTICAL EXCITATORY AND INHIBITORY NEUROTRANSMITTER SYSTEMS UNDERLIES THESE DEFICITS. GAMMA-AMINOBUTYRIC ACID (GABA) AND GLUTAMATE ARE THE MOST ABUNDANT EXCITATORY AND INHIBITORY NEUROTRANSMITTERS IN THE BRAIN THAT CONTRIBUTE TO THIS EQUILIBRIUM. SEVERAL CONTEMPORARY THERAPIES USED IN TREATING PSYCHIATRIC DISORDERS, REGULATE THIS GABA-GLUTAMATE BALANCE. YOGA HAS BEEN STUDIED AS AN ADJUVANT TREATMENT ACROSS A BROAD RANGE OF PSYCHIATRIC DISORDERS AND IS SHOWN TO HAVE SHORT-TERM THERAPEUTIC GAINS. EMERGING EVIDENCE FROM RECENT CLINICAL IN VIVO EXPERIMENTS SUGGESTS THAT YOGA IMPROVES GABA-MEDIATED CORTICAL-INHIBITORY TONE AND ENHANCES PERIPHERAL OXYTOCIN LEVELS. THIS IS LIKELY TO HAVE A MORE CONTROLLED DOWNSTREAM RESPONSE OF THE HYPOTHALAMO-PITUITARY-ADRENAL SYSTEM BY MEANS OF REDUCED CORTISOL RELEASE AND HENCE A BLUNTED SYMPATHETIC RESPONSE TO STRESS. ANIMAL AND EARLY FETAL DEVELOPMENTAL STUDIES SUGGEST AN INTER-DEPENDENT ROLE OF OXYTOCIN AND GABA IN REGULATING SOCIAL BEHAVIORS. IN KEEPING WITH THESE OBSERVATIONS, WE PROPOSE AN INTEGRATED NEUROBIOLOGICAL MODEL TO STUDY THE MECHANISMS OF THERAPEUTIC BENEFITS WITH YOGA. APART FROM PROVIDING A NEUROSCIENTIFIC BASIS FOR APPLYING A TRADITIONAL SYSTEM OF PRACTICE IN THE CLINICAL SETTING, THIS MODEL CAN BE USED AS A FRAMEWORK FOR STUDYING YOGA MECHANISMS IN FUTURE CLINICAL TRIALS. 2019 8 2781 32 YOGA THERAPY AND POLYVAGAL THEORY: THE CONVERGENCE OF TRADITIONAL WISDOM AND CONTEMPORARY NEUROSCIENCE FOR SELF-REGULATION AND RESILIENCE. YOGA THERAPY IS A NEWLY EMERGING, SELF-REGULATING COMPLEMENTARY AND INTEGRATIVE HEALTHCARE (CIH) PRACTICE. IT IS GROWING IN ITS PROFESSIONALIZATION, RECOGNITION AND UTILIZATION WITH A DEMONSTRATED COMMITMENT TO SETTING PRACTICE STANDARDS, EDUCATIONAL AND ACCREDITATION STANDARDS, AND PROMOTING RESEARCH TO SUPPORT ITS EFFICACY FOR VARIOUS POPULATIONS AND CONDITIONS. HOWEVER, HETEROGENEITY OF PRACTICE, POOR REPORTING STANDARDS, AND LACK OF A BROADLY ACCEPTED UNDERSTANDING OF THE NEUROPHYSIOLOGICAL MECHANISMS INVOLVED IN YOGA THERAPY LIMITS THE STRUCTURING OF TESTABLE HYPOTHESES AND CLINICAL APPLICATIONS. CURRENT PROPOSED FRAMEWORKS OF YOGA-BASED PRACTICES FOCUS ON THE INTEGRATION OF BOTTOM-UP NEUROPHYSIOLOGICAL AND TOP-DOWN NEUROCOGNITIVE MECHANISMS. IN ADDITION, IT HAS BEEN PROPOSED THAT PHENOMENOLOGY AND FIRST PERSON ETHICAL INQUIRY CAN PROVIDE A LENS THROUGH WHICH YOGA THERAPY IS VIEWED AS A PROCESS THAT CONTRIBUTES TOWARDS EUDAIMONIC WELL-BEING IN THE EXPERIENCE OF PAIN, ILLNESS OR DISABILITY. IN THIS ARTICLE WE BUILD ON THESE FRAMEWORKS, AND PROPOSE A MODEL OF YOGA THERAPY THAT CONVERGES WITH POLYVAGAL THEORY (PVT). PVT LINKS THE EVOLUTION OF THE AUTONOMIC NERVOUS SYSTEM TO THE EMERGENCE OF PROSOCIAL BEHAVIORS AND POSITS THAT THE NEURAL PLATFORMS SUPPORTING SOCIAL BEHAVIOR ARE INVOLVED IN MAINTAINING HEALTH, GROWTH AND RESTORATION. THIS EXPLANATORY MODEL WHICH CONNECTS NEUROPHYSIOLOGICAL PATTERNS OF AUTONOMIC REGULATION AND EXPRESSION OF EMOTIONAL AND SOCIAL BEHAVIOR, IS INCREASINGLY UTILIZED AS A FRAMEWORK FOR UNDERSTANDING HUMAN BEHAVIOR, STRESS AND ILLNESS. SPECIFICALLY, WE DESCRIBE HOW PVT CAN BE CONCEPTUALIZED AS A NEUROPHYSIOLOGICAL COUNTERPART TO THE YOGIC CONCEPT OF THE GUNAS, OR QUALITIES OF NATURE. SIMILAR TO THE NEURAL PLATFORMS DESCRIBED IN PVT, THE GUNAS PROVIDE THE FOUNDATION FROM WHICH BEHAVIORAL, EMOTIONAL AND PHYSICAL ATTRIBUTES EMERGE. WE DESCRIBE HOW THESE TWO DIFFERENT YET ANALOGOUS FRAMEWORKS-ONE BASED IN NEUROPHYSIOLOGY AND THE OTHER IN AN ANCIENT WISDOM TRADITION-HIGHLIGHT YOGA THERAPY'S PROMOTION OF PHYSICAL, MENTAL AND SOCIAL WELLBEING FOR SELF-REGULATION AND RESILIENCE. THIS PARALLEL BETWEEN THE NEURAL PLATFORMS OF PVT AND THE GUNAS OF YOGA IS INSTRUMENTAL IN CREATING A TRANSLATIONAL FRAMEWORK FOR YOGA THERAPY TO ALIGN WITH ITS PHILOSOPHICAL FOUNDATIONS. CONSEQUENTLY, YOGA THERAPY CAN OPERATE AS A DISTINCT PRACTICE RATHER THAN FITTING INTO AN OUTSIDE MODEL FOR ITS UTILIZATION IN RESEARCH AND CLINICAL CONTEXTS. 2018 9 1775 11 PRACTICE OF YOGA MAY CAUSE DAMAGE OF BOTH SCIATIC NERVES: A CASE REPORT. SCIATIC NERVE TRAUMATIC DAMAGE VERY RARELY OCCURS BILATERALLY. WE DESCRIBE THE CASE OF A 67-YEAR-OLD WOMAN WHO REPORTED A BILATERAL TRAUMATIC LESION OF THE SCIATIC NERVE DURING PRACTICE OF YOGA. NERVE CONDUCTION STUDIES SHOWED A BILATERAL SCIATIC NERVE NEUROPATHY, MOSTLY AFFECTING THE PERONEAL COMPONENT. LUMBAR PLEXUS MRI DOCUMENTED REGULAR ANATOMICAL FEATURES OF THE MAIN PRINCIPAL NERVE ROOTS WITH BILATERAL T2 SIGNAL ALTERATION OF ROOTS L4, L5 AND S1 THAT EXTENDED INTO THE SCIATIC NERVES SHOWING BOTH INCREASE IN SIZE, PROBABLY RELATED TO CHRONIC INJURY OF NERVES, AND AN ALTERATION IN DIFFUSION SIGNAL THAT SUGGESTED A RECENT ACUTE OVERLAPPED PROCESS. 2013 10 1985 20 SOME THOUGHTS ON NEUROPHYSIOLOGICAL BASIS OF YOGA. YOGA PRESENTS THE CULMINATION OF EFFORTS MADE BY MANKIND TILL NOW CONTROL MIND AND BEHAVIOUR. IT IS LIVING SCIENCE, PRACTICED IN AN ELEMENTARY FASHION BY MANY IN INDIA. WHILE A FEW PERHAPS ARE THERE WHO HAVE ATTAINED MASTERY OF THIS SCIENCE.THE BACKGROUND OF THE DERIVATION AND CONCEPT OF YOGA IN INDIA IS PRESENTED FOLLOWED BY A SIMPLE EXPOSITION OF YOGIC PRACTICES AND SOME POSSIBLE NEUROPHYSIOLOGIC EXPLANATIONS. RESEARCH IN YOGA WILL BE REWARDING AS IT GIVES MEANS OF EXPLORING AND ENLARGING THE FUNCTIONS OF THE HUMAN BRAIN. 1981 11 2887 25 YOGA: CAN IT BE INTEGRATED WITH TREATMENT OF NEUROPATHIC PAIN? BACKGROUND: NEUROPATHIC PAIN (NP) IS A DEBILITATING CONDITION THAT MAY RESULT FROM SPINAL CORD INJURY (SCI). NEARLY 75% OF ALL SCI RESULTS IN NP AFFECTING 17,000 NEW INDIVIDUALS IN THE UNITED STATES EVERY YEAR, AND AN ESTIMATED 7-10% OF PEOPLE WORLDWIDE. IT IS CAUSED BY DAMAGED OR DYSFUNCTIONAL NERVE FIBERS SENDING ABERRANT SIGNALS TO PAIN CENTERS IN THE CENTRAL NERVOUS SYSTEM CAUSING SEVERE PAIN THAT AFFECTS DAILY LIFE AND ROUTINE. THE MECHANISMS UNDERLYING NP ARE NOT FULLY UNDERSTOOD, MAKING TREATMENT DIFFICULT. IDENTIFICATION OF SPECIFIC MOLECULAR PATHWAYS THAT ARE INVOLVED IN PAIN SYNDROMES AND FINDING EFFECTIVE TREATMENTS HAS BECOME A MAJOR PRIORITY IN CURRENT SCI RESEARCH. YOGA HAS THERAPEUTIC APPLICATIONS MAY PROVE BENEFICIAL IN TREATING SUBJECTS SUFFERING CHRONICALLY WITH SCI INDUCED NP, CHRONIC BACK AND ASSOCIATED PAINS IF NECESSARY EXPERIMENTAL DATA IS GENERATED. SUMMARY: THIS REVIEW AIMS TO DISCUSS THE IMPLICATIONS OF VARIOUS MECHANISTIC APPROACHES OF YOGA WHICH CAN BE TESTED BY NEW STUDY DESIGNS AROUND VARIOUS NOCICEPTIVE MOLECULES INCLUDING MATRIX METALLOPROTEINASES (MMPS), CATION-DEPENDENT CHLORIDE TRANSPORTER (NKCC1) ETC IN SCI INDUCED NP PATIENTS. KEY MESSAGES: THUS, YOGIC PRACTICES COULD BE USED IN MANAGING SCI INDUCED NP PAIN BY REGULATING THE ACTION OF VARIOUS MECHANISMS AND ITS ASSOCIATED MOLECULES. MODERN PRESCRIPTIVE TREATMENT STRATEGIES COMBINED WITH ALTERNATIVE APPROACHES LIKE YOGA SHOULD BE USED IN REHABILITATION CENTERS AND CLINICS IN ORDER TO AMELIORATE CHRONIC NP. WE RECOMMEND PRACTICAL CONSIDERATIONS OF CAREFUL YOGA PRACTICE AS PART OF AN INTEGRATIVE MEDICINE APPROACH FOR NP ASSOCIATED WITH SCI. 2019 12 2608 11 YOGA FOR PSYCHIATRIC DISORDERS: FROM FAD TO EVIDENCE-BASED INTERVENTION? THERE IS GROWING EVIDENCE FOR YOGA'S NEUROBIOLOGICAL EFFECTS IN PEOPLE WITH PSYCHIATRIC DISORDERS. POSTULATED MECHANISMS OF ACTION INCLUDE: (A) MODULATION OF THE HYPOTHALAMIC-PITUITARY-ADRENAL (HPA) AXIS; (B) ENHANCEMENT OF GABAERGIC NEUROTRANSMISSION; (C) AUTONOMIC MODULATION; AND (D) NEUROENDOCRINOLOGICAL EFFECTS. YOGA AS A THERAPEUTIC INTERVENTION IN PSYCHIATRIC DISORDERS APPEARS PROMISING AND MERITS FURTHER ATTENTION IN CLINICAL PRACTICE AND RESEARCH. 2020 13 1817 20 PROPOSED IDENTIFICATION OF PHYSIOLOGICAL CLASSIFICATION AND THEORETICAL MECHANISMS OF YOGASANAS. YOGA IN THE THEORETICAL AND PRACTICAL FORM IS NOW ACCEPTED ALL OVER THE WORLD, BY THE RESEARCHERS AS WELL AS BY THE GENERAL POPULATION. YOGASANA OR YOGIC POSTURES ARE ONE OF THE MAIN FOUNDATIONS OF PRACTICAL YOGA. MECHANISMS OF MEDIATION AND PRANAYAMA HAS ALREADY BEEN ESTABLISHED. IN THIS ARTICLE, THE AUTHOR IS FOR THE FIRST TIME PROPOSING PHYSIOLOGICAL CLASSIFICATION OF YOGASANA I.E. (A) STRETCH (B) CONTRACTION (C). NEUROMUSCULAR COORDINATION (D) SENSE REDUCTION (E) SPINE BRAIN ACTIVATION. IN SUPPORT OF THIS PHYSIOLOGICAL CLASSIFICATION AUTHOR HAS PROPOSED FIVE HYPOTHETICAL THEORIES I.E. (I) STRETCH RELAXATION AWARENESS (II) CONTRACTION RELAXATION AWARENESS (III) BALLASTIC CONTRACTION RELAXATION AWARENESS (IV) SENSORY MOTOR FUNCTION AWARENESS AND (V) VITAL ENERGY FLOW AWARENESS TO UNDERSTAND THE UNDERLYING MECHANISMS OF YOGASANA PRACTICE AND TO EXPLAIN ITS BENEFITS. 2021 14 2297 17 THERAPEUTIC ROLE OF YOGA IN NEUROPSYCHOLOGICAL DISORDERS. YOGA IS CONSIDERED A WIDELY-USED APPROACH FOR HEALTH CONSERVATION AND CAN BE ADOPTED AS A TREATMENT MODALITY FOR A PLETHORA OF MEDICAL CONDITIONS, INCLUDING NEUROLOGICAL AND PSYCHOLOGICAL DISORDERS. HENCE, WE REVIEWED RELEVANT ARTICLES ENTAILING VARIOUS NEUROLOGICAL AND PSYCHOLOGICAL DISORDERS AND GATHERED DATA ON HOW YOGA EXERTS POSITIVE IMPACTS ON PATIENTS WITH A DIVERSE RANGE OF DISORDERS, INCLUDING ITS MODULATORY EFFECTS ON BRAIN BIOELECTRICAL ACTIVITIES, NEUROTRANSMITTERS, AND SYNAPTIC PLASTICITY. THE ROLE OF YOGA PRACTICE AS AN ELEMENT OF THE TREATMENT OF SEVERAL NEUROPSYCHOLOGICAL DISEASES WAS EVALUATED BASED ON THESE FINDINGS. 2021 15 1772 23 POTENTIAL SELF-REGULATORY MECHANISMS OF YOGA FOR PSYCHOLOGICAL HEALTH. RESEARCH SUGGESTING THE BENEFICIAL EFFECTS OF YOGA ON MYRIAD ASPECTS OF PSYCHOLOGICAL HEALTH HAS PROLIFERATED IN RECENT YEARS, YET THERE IS CURRENTLY NO OVERARCHING FRAMEWORK BY WHICH TO UNDERSTAND YOGA'S POTENTIAL BENEFICIAL EFFECTS. HERE WE PROVIDE A THEORETICAL FRAMEWORK AND SYSTEMS-BASED NETWORK MODEL OF YOGA THAT FOCUSES ON INTEGRATION OF TOP-DOWN AND BOTTOM-UP FORMS OF SELF-REGULATION. WE BEGIN BY CONTEXTUALIZING YOGA IN HISTORICAL AND CONTEMPORARY SETTINGS, AND THEN DETAIL HOW SPECIFIC COMPONENTS OF YOGA PRACTICE MAY AFFECT COGNITIVE, EMOTIONAL, BEHAVIORAL, AND AUTONOMIC OUTPUT UNDER STRESS THROUGH AN EMPHASIS ON INTEROCEPTION AND BOTTOM-UP INPUT, RESULTING IN PHYSICAL AND PSYCHOLOGICAL HEALTH. THE MODEL DESCRIBES YOGA PRACTICE AS A COMPREHENSIVE SKILLSET OF SYNERGISTIC PROCESS TOOLS THAT FACILITATE BIDIRECTIONAL FEEDBACK AND INTEGRATION BETWEEN HIGH- AND LOW-LEVEL BRAIN NETWORKS, AND AFFERENT AND RE-AFFERENT INPUT FROM INTEROCEPTIVE PROCESSES (SOMATOSENSORY, VISCEROSENSORY, CHEMOSENSORY). FROM A PREDICTIVE CODING PERSPECTIVE WE PROPOSE A SHIFT TO PERCEPTUAL INFERENCE FOR STRESS MODULATION AND OPTIMAL SELF-REGULATION. WE DESCRIBE HOW THE PROCESSES THAT SUB-SERVE SELF-REGULATION BECOME MORE AUTOMATIZED AND EFFICIENT OVER TIME AND PRACTICE, REQUIRING LESS EFFORT TO INITIATE WHEN NECESSARY AND TERMINATE MORE RAPIDLY WHEN NO LONGER NEEDED. TO SUPPORT OUR PROPOSED MODEL, WE PRESENT THE AVAILABLE EVIDENCE FOR YOGA AFFECTING SELF-REGULATORY PATHWAYS, INTEGRATING EXISTING CONSTRUCTS FROM BEHAVIOR THEORY AND COGNITIVE NEUROSCIENCE WITH EMERGING YOGA AND MEDITATION RESEARCH. THIS PAPER IS INTENDED TO GUIDE FUTURE BASIC AND CLINICAL RESEARCH, SPECIFICALLY TARGETING AREAS OF DEVELOPMENT IN THE TREATMENT OF STRESS-MEDIATED PSYCHOLOGICAL DISORDERS. 2014 16 2714 31 YOGA LESSONS FOR CONSCIOUSNESS RESEARCH: A PARALIMBIC NETWORK BALANCING BRAIN RESOURCE ALLOCATION. CONSCIOUSNESS HAS BEEN PROPOSED TO PLAY A KEY ROLE IN SHAPING FLEXIBLE LEARNING AND AS SUCH IS THOUGHT TO CONFER AN EVOLUTIONARY ADVANTAGE. ATTENTION AND AWARENESS ARE THE PERHAPS MOST IMPORTANT UNDERLYING PROCESSES, YET THEIR PRECISE RELATIONSHIP IS PRESENTLY UNCLEAR. BOTH OF THESE PROCESSES MUST, HOWEVER, SERVE THE EVOLUTIONARY IMPERATIVES OF SURVIVAL AND PROCREATION. THEY ARE THUS INTIMATELY BOUND BY REWARD AND EMOTION TO HELP TO PRIORITIZE EFFICIENT BRAIN RESOURCE ALLOCATION IN ORDER TO PREDICT AND OPTIMIZE BEHAVIOR. HERE WE SHOW HOW THIS PROCESS IS SERVED BY A PARALIMBIC NETWORK CONSISTING PRIMARILY OF REGIONS LOCATED ON THE MIDLINE OF THE HUMAN BRAIN. USING MANY DIFFERENT TECHNIQUES, EXPERIMENTS HAVE DEMONSTRATED THAT THIS NETWORK IS EFFECTIVE AND SPECIFIC FOR SELF-AWARENESS AND CONTRIBUTES TO THE SENSE OF UNITY OF CONSCIOUSNESS BY ACTING AS A COMMON NEURAL PATH FOR A WIDE VARIETY OF CONSCIOUS EXPERIENCES. INTERESTINGLY, HEMODYNAMIC ACTIVITY IN THE NETWORK DECREASES WITH FOCUSING ON EXTERNAL STIMULI, WHICH HAS LED TO THE IDEA OF A DEFAULT MODE NETWORK. THIS NETWORK IS ONE OF MANY NETWORKS THAT WAX AND VANE AS RESOURCES ARE ALLOCATED TO ACCOMMODATE THE DIFFERENT CYCLICAL NEEDS OF THE ORGANISM PRIMARILY RELATED TO THE FUNDAMENTAL PLEASURES AFFORDED BY EVOLUTION: FOOD, SEX, AND CONSPECIFICS. HERE WE HYPOTHESIZE, HOWEVER, THAT THE PARALIMBIC NETWORK SERVES A CRUCIAL ROLE IN BALANCING AND REGULATING BRAIN RESOURCE ALLOCATION, AND DISCUSS HOW IT CAN BE THOUGHT OF AS A LINK BETWEEN CURRENT THEORIES OF SO-CALLED "DEFAULT MODE," "RESTING STATE NETWORKS," AND "GLOBAL WORKSPACE." WE SHOW HOW MAJOR DEVELOPMENTAL DISORDERS OF SELF-AWARENESS AND SELF-CONTROL CAN ARISE FROM PROBLEMS IN THE PARALIMBIC NETWORK AS DEMONSTRATED HERE BY THE EXAMPLE OF ASPERGER SYNDROME. WE CONCLUDE THAT ATTENTION, AWARENESS, AND EMOTION ARE INTEGRATED BY A PARALIMBIC NETWORK THAT HELPS TO EFFICIENTLY ALLOCATE BRAIN RESOURCES TO OPTIMIZE BEHAVIOR AND HELP SURVIVAL. 2011 17 2371 16 WHAT HAS NEUROIMAGING TAUGHT US ON THE NEUROBIOLOGY OF YOGA? A REVIEW. YOGA IS BECOMING INCREASINGLY POPULAR WORLDWIDE, WITH SEVERAL IMPLICATED PHYSICAL AND MENTAL BENEFITS. HERE WE PROVIDE A COMPREHENSIVE AND CRITICAL REVIEW OF THE RESEARCH GENERATED FROM THE EXISTING NEUROIMAGING LITERATURE IN STUDIES OF YOGA PRACTITIONERS. WE REVIEWED 34 INTERNATIONAL PEER-REVIEWED NEUROIMAGING STUDIES OF YOGA USING MAGNETIC RESONANCE IMAGING (MRI), POSITRON EMISSION TOMOGRAPHY (PET), OR SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY (SPECT): 11 MORPHOLOGICAL AND 26 FUNCTIONAL STUDIES, INCLUDING THREE STUDIES THAT WERE CLASSIFIED AS BOTH MORPHOLOGICAL AND FUNCTIONAL. CONSISTENT FINDINGS INCLUDE INCREASED GRAY MATTER VOLUME IN THE INSULA AND HIPPOCAMPUS, INCREASED ACTIVATION OF PREFRONTAL CORTICAL REGIONS, AND FUNCTIONAL CONNECTIVITY CHANGES MAINLY WITHIN THE DEFAULT MODE NETWORK. THERE IS QUITE SOME VARIABILITY IN THE NEUROIMAGING FINDINGS THAT PARTIALLY REFLECTS DIFFERENT YOGA STYLES AND APPROACHES, AS WELL AS SAMPLE SIZE LIMITATIONS. DIRECT COMPARATOR GROUPS SUCH AS PHYSICAL ACTIVITY ARE SCARCELY USED SO FAR. FINALLY, HYPOTHESES ON THE UNDERLYING NEUROBIOLOGY DERIVED FROM THE IMAGING FINDINGS ARE DISCUSSED IN THE LIGHT OF THE POTENTIAL BENEFICIAL EFFECTS OF YOGA. 2020 18 1191 17 EVOLUTION FROM FOUR MENTAL STATES TO THE HIGHEST STATE OF CONSCIOUSNESS: A NEUROPHYSIOLOGICAL BASIS OF MEDITATION AS DEFINED IN YOGA TEXTS. THIS CHAPTER PROVIDES A THEORETICAL INTRODUCTION TO STATES OF CONSCIOUSNESS AND REVIEWS NEUROSCIENTIFIC INVESTIGATIONS OF MEDITATION. THE DIFFERENT STATES OF CONSCIOUSNESS CONSIST OF FOUR MENTAL STATES, I.E., CANCALATA (RANDOM THINKING), EKAGRATA (NON-MEDITATIVE FOCUSING), DHARNA (FOCUSED MEDITATION), AND DHYANA (MEDITATION) AS DEFINED IN YOGA TEXTS. MEDITATION IS A SELF-REGULATED MENTAL PROCESS ASSOCIATED WITH DEEP RELAXATION AND INCREASED INTERNALIZED ATTENTION. SCIENTIFIC INVESTIGATIONS ON MEDITATION REPORTED CHANGES IN ELECTROPHYSIOLOGICAL SIGNALS AND NEUROIMAGING MEASURES. BUT MOST OUTCOMES OF MEDITATION STUDIES SHOWED INCONSISTENT RESULTS, THIS MAY BE DUE TO HETEROGENEITY IN MEDITATION METHODS AND TECHNIQUES EVOLVED IN THE LAST 200 YEARS. TRADITIONALLY, THE FEATURES OF MEDITATION INCLUDE THE CAPACITY TO SUSTAIN A HEIGHTENED AWARENESS OF THOUGHTS, BEHAVIORS, EMOTIONS, AND PERCEPTIONS. GENERALLY, MEDITATION INVOLVES NON-REACTIVE EFFORTLESS MONITORING OF THE CONTENT OF EXPERIENCE FROM MOMENT TO MOMENT. FOCUSED MEDITATION PRACTICE INVOLVES AWARENESS ON A SINGLE OBJECT AND OPEN MONITORING MEDITATION IS A NON-DIRECTIVE MEDITATION INVOLVED ATTENTION IN BREATHING, MANTRA, OR SOUND. THEREFORE, RESULTS OF FEW EMPIRICAL STUDIES OF ADVANCED MEDITATORS OR BEGINNERS REMAIN TENTATIVE. THIS IS AN ATTEMPT TO COMPILE THE MEDITATION-RELATED CHANGES IN ELECTROPHYSIOLOGICAL AND NEUROIMAGING PROCESSES AMONG EXPERIENCED AND NOVICE PRACTITIONERS. 2019 19 2502 24 YOGA AS THERAPY IN PSYCHOSOMATIC MEDICINE. YOGA AS THERAPY WITH PSYCHOSOMATIC DISORDERS HAS BEEN PRACTICED FOR MANY CENTURIES IN INDIA, AND ONLY RECENTLY HAS BECOME UTILIZED FOR THIS PURPOSE IN OTHER COUNTRIES. THE YOGA SYSTEM EVOLVED AS A 'SYSTEM OF LIBERATION' TO ALLOW MAN TO DISCRIMINATE BETWEEN HIS EGO-SELF AND PURE CONSCIOUSNESS, AND AS SUCH, ITS MEDICAL BENEFITS ARE REALLY 'SIDE-EFFECTS'. INTEGRAL YOGA PRACTICE, HOWEVER, WITH WHICH MANY OTHER SELF-REGULATORY SOMATOPSYCHIC APPROACHES HAVE MUCH IN COMMON, CONSISTS OF A HOLISTIC TECHNOLOGY WHICH FUNCTIONS TO RESTORE OPTIMAL HOMEOSTATIS BY A VARIETY OF SPECIAL TECHNIQUES NOT FOUND IN OTHER APPROACHES. CLINICAL OBSERVATIONS OF PSYCHOSOMATIC PATIENTS INDICATE THAT THEIR DISTORTED SOMATOPSYCHIC FUNCTIONING NECESSITATES THEIR PRACTICE OF YOGA-LIKE THERAPY. A REVIEW OF THE CLINICAL EVIDENCE AVAILABLE INDICATES THAT YOGA PRACTICE HAS PROVEN MOST EFFECTIVE WITH A WIDE RANGE OF PSYCHOSOMATIC AND PSYCHIATRIC DISORDERS. THE EFFECTIVENESS OF YOGA CAN BE PARTIALLY UNDERSTOOD IN TERMS OF NEUROPHYSIOLOGICAL THEORY. 1979 20 2305 24 TRAINING ATTENTION FOR CONSCIOUS NON-REM SLEEP: THE YOGIC PRACTICE OF YOGA-NIDRA AND ITS IMPLICATIONS FOR NEUROSCIENCE RESEARCH. THE STUDY OF CONSCIOUSNESS WITHIN COGNITIVE NEUROSCIENCE HAS BEEN DOMINATED IN RECENT YEARS BY INVESTIGATIONS ORIGINATING FROM COLLABORATIONS BETWEEN NEUROSCIENTIFIC INVESTIGATORS AND BUDDHIST MEDITATION PRACTITIONERS. THE RESULTS HAVE BEEN REMARKABLE, PARTICULARLY WHEN QUANTITATIVE AND QUALITATIVE RESEARCH METHODS HAVE BEEN COMBINED AS THEY ARE IN THE NEUROPHENOMENOLOGICAL METHODOLOGY ORIGINATED BY FRANCISCO VARELA. THE ADDITION OF QUALITATIVE DATA ABOUT THE EXPERIENCE OF THE SUBJECT GREATLY ENRICHES THE INTERPRETIVE POTENTIAL OF QUANTITATIVE DATA AND HONORS THE ULTIMATE SUBJECTIVITY OF ALL PHENOMENA, IF WE ACCEPT CONSCIOUSNESS AS THE UNIVERSAL FIRST PRINCIPLE AS SOME QUANTUM PHYSICISTS NOW DO. THIS REMARKABLE PROGRESS, HOWEVER, HAS DROPPED A THREAD OF INQUIRY BEGUN IN THE LATE 1960S BY THE MENNINGER FOUNDATION IN TOPEKA, KANSAS (THE UNITED STATES) UNDER THE LEADERSHIP OF ELMER AND ALYCE GREEN. THEIR STUDIES OF THE CONSCIOUS CONTROL OF INVOLUNTARY PROCESSES DREW ON COLLABORATION WITH AN INDIAN MASTER OF YOGA MEDITATION, SWAMI RAMA OF THE HIMALAYAS, WHICH OPENED A NUMBER OF INTRIGUING POSSIBILITIES, WHICH HAVE YET TO BE FOLLOWED UP IN DETAIL WITH THE MOST RECENT RESEARCH TOOLS AND METHODOLOGIES. AMONG THESE IS THE ABILITY TO ENTER THE DEEPEST, NON-REM DELTA WAVE SLEEP WHILE MAINTAINING AWARENESS BOTH INTERNALLY AND OF ONE'S SURROUNDINGS (YOGA-NIDRA). THE PARTICULAR INTEREST IN THIS ABILITY LIES NOT ONLY IN THE BENEFITS THAT ACCRUE FROM ESPECIALLY DEEP RELAXATION AND AN ESPECIALLY PURE EXPERIENCE OF MINDFUL AWARENESS, BUT ALSO FROM THE YOGI'S DESCRIPTION OF THIS AS A WAY TO GRADUALLY LEARN TO ENTER THE DEEPEST STATES OF MEDITATION (SAMADHI) AND REMAIN THERE EVEN WHEN OTHERWISE ACTIVE IN THE WORLD (TURIYA). THIS CHAPTER IS ONE OF A SERIES HOPING TO ELUCIDATE THAT STATE FROM BOTH TRADITIONAL AND CONTEMPORARY DESCRIPTIONS OF THE STATE OF YOGA-NIDRA, DRAW MEASURABLE HYPOTHESES FROM THESE DESCRIPTIONS AND DISCUSS THE METHODOLOGICAL PROBLEMS OF CONDUCTING THESE INVESTIGATIONS WITH SUFFICIENTLY COMPETENT SAMPLES OF SUBJECTS. THE FOCUS OF THIS CHAPTER IS ON TRAINING SUBJECTS WHO CAN BECOME CAPABLE OF ENTERING THE STATE OF YOGA-NIDRA. 2019