1 2371 116 WHAT HAS NEUROIMAGING TAUGHT US ON THE NEUROBIOLOGY OF YOGA? A REVIEW. YOGA IS BECOMING INCREASINGLY POPULAR WORLDWIDE, WITH SEVERAL IMPLICATED PHYSICAL AND MENTAL BENEFITS. HERE WE PROVIDE A COMPREHENSIVE AND CRITICAL REVIEW OF THE RESEARCH GENERATED FROM THE EXISTING NEUROIMAGING LITERATURE IN STUDIES OF YOGA PRACTITIONERS. WE REVIEWED 34 INTERNATIONAL PEER-REVIEWED NEUROIMAGING STUDIES OF YOGA USING MAGNETIC RESONANCE IMAGING (MRI), POSITRON EMISSION TOMOGRAPHY (PET), OR SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY (SPECT): 11 MORPHOLOGICAL AND 26 FUNCTIONAL STUDIES, INCLUDING THREE STUDIES THAT WERE CLASSIFIED AS BOTH MORPHOLOGICAL AND FUNCTIONAL. CONSISTENT FINDINGS INCLUDE INCREASED GRAY MATTER VOLUME IN THE INSULA AND HIPPOCAMPUS, INCREASED ACTIVATION OF PREFRONTAL CORTICAL REGIONS, AND FUNCTIONAL CONNECTIVITY CHANGES MAINLY WITHIN THE DEFAULT MODE NETWORK. THERE IS QUITE SOME VARIABILITY IN THE NEUROIMAGING FINDINGS THAT PARTIALLY REFLECTS DIFFERENT YOGA STYLES AND APPROACHES, AS WELL AS SAMPLE SIZE LIMITATIONS. DIRECT COMPARATOR GROUPS SUCH AS PHYSICAL ACTIVITY ARE SCARCELY USED SO FAR. FINALLY, HYPOTHESES ON THE UNDERLYING NEUROBIOLOGY DERIVED FROM THE IMAGING FINDINGS ARE DISCUSSED IN THE LIGHT OF THE POTENTIAL BENEFICIAL EFFECTS OF YOGA. 2020 2 1698 26 PAIN-RELATED ENCEPHALIC REGIONS INFLUENCED BY YOGA MEDITATION: AN INTEGRATIVE REVIEW. INTRODUCTION: THE MECHANISMS UNDERLYING THE USE OF YOGA IN PAIN RELIEF ARE STILL UNCLEAR. THIS STUDY REVIEWED LITERATURE REPORTS ON ENCEPHALIC ACTIVITY RELATED TO ANALGESIA INDUCED BY YOGA MEDITATION PRACTICE. METHODS: THIS INTEGRATIVE REVIEW EXAMINED STUDIES PUBLISHED IN THE PUBMED, LILACS AND MEDLINE DATABASES WITHOUT RESTRICTION OF THE YEAR OF PUBLICATION. THE RESEARCH INVOLVED 16 DESCRIPTORS RELATED TO THE WORDS: YOGA, PAIN AND NEUROIMAGING METHODS. INCLUSION CRITERIA INVOLVED ONLY THE PUBLICATIONS AVAILABLE ONLINE, WITH FREE ACCESS AND WRITTEN IN ENGLISH. RESULTS: 2 CASE STUDIES AND 1 PILOT STUDY MET THE CRITERIA. YOGA MEDITATION PRACTICE INDUCES ANALGESIA PRIMARILY THROUGH ATTENUATION OF THE MEDIAL PAIN PERCEPTION SYSTEM INCLUDING THE ANTERIOR CINGULATE CORTEX AND INSULA REGIONS, AS WELL AS THE LATERAL SYSTEM INCLUDING THE SECONDARY SENSORY CORTEX AND THALAMUS. CONCLUSION: YOGA INDUCED ANALGESIA IS A POTENTIALLY IMPORTANT ADJUNCT TO CURRENT PAIN MANAGEMENT. THIS INTEGRATIVE REVIEW REVEALED THAT THERE IS A NEED FOR FURTHER RESEARCH THAT ANALYZES THE ENCEPHALIC REGIONS RELATED TO ANALGESIA INDUCED BY YOGA PRACTICE. 2018 3 1191 22 EVOLUTION FROM FOUR MENTAL STATES TO THE HIGHEST STATE OF CONSCIOUSNESS: A NEUROPHYSIOLOGICAL BASIS OF MEDITATION AS DEFINED IN YOGA TEXTS. THIS CHAPTER PROVIDES A THEORETICAL INTRODUCTION TO STATES OF CONSCIOUSNESS AND REVIEWS NEUROSCIENTIFIC INVESTIGATIONS OF MEDITATION. THE DIFFERENT STATES OF CONSCIOUSNESS CONSIST OF FOUR MENTAL STATES, I.E., CANCALATA (RANDOM THINKING), EKAGRATA (NON-MEDITATIVE FOCUSING), DHARNA (FOCUSED MEDITATION), AND DHYANA (MEDITATION) AS DEFINED IN YOGA TEXTS. MEDITATION IS A SELF-REGULATED MENTAL PROCESS ASSOCIATED WITH DEEP RELAXATION AND INCREASED INTERNALIZED ATTENTION. SCIENTIFIC INVESTIGATIONS ON MEDITATION REPORTED CHANGES IN ELECTROPHYSIOLOGICAL SIGNALS AND NEUROIMAGING MEASURES. BUT MOST OUTCOMES OF MEDITATION STUDIES SHOWED INCONSISTENT RESULTS, THIS MAY BE DUE TO HETEROGENEITY IN MEDITATION METHODS AND TECHNIQUES EVOLVED IN THE LAST 200 YEARS. TRADITIONALLY, THE FEATURES OF MEDITATION INCLUDE THE CAPACITY TO SUSTAIN A HEIGHTENED AWARENESS OF THOUGHTS, BEHAVIORS, EMOTIONS, AND PERCEPTIONS. GENERALLY, MEDITATION INVOLVES NON-REACTIVE EFFORTLESS MONITORING OF THE CONTENT OF EXPERIENCE FROM MOMENT TO MOMENT. FOCUSED MEDITATION PRACTICE INVOLVES AWARENESS ON A SINGLE OBJECT AND OPEN MONITORING MEDITATION IS A NON-DIRECTIVE MEDITATION INVOLVED ATTENTION IN BREATHING, MANTRA, OR SOUND. THEREFORE, RESULTS OF FEW EMPIRICAL STUDIES OF ADVANCED MEDITATORS OR BEGINNERS REMAIN TENTATIVE. THIS IS AN ATTEMPT TO COMPILE THE MEDITATION-RELATED CHANGES IN ELECTROPHYSIOLOGICAL AND NEUROIMAGING PROCESSES AMONG EXPERIENCED AND NOVICE PRACTITIONERS. 2019 4 1439 29 INCREASED GREY MATTER ASSOCIATED WITH LONG-TERM SAHAJA YOGA MEDITATION: A VOXEL-BASED MORPHOMETRY STUDY. OBJECTIVES: TO INVESTIGATE REGIONAL DIFFERENCES IN GREY MATTER VOLUME ASSOCIATED WITH THE PRACTICE OF SAHAJA YOGA MEDITATION. DESIGN: TWENTY THREE EXPERIENCED PRACTITIONERS OF SAHAJA YOGA MEDITATION AND TWENTY THREE NON-MEDITATORS MATCHED ON AGE, GENDER AND EDUCATION LEVEL, WERE SCANNED USING STRUCTURAL MAGNETIC RESONANCE IMAGING AND THEIR GREY MATTER VOLUME WERE COMPARED USING VOXEL-BASED MORPHOMETRY. RESULTS: GREY MATTER VOLUME WAS LARGER IN MEDITATORS RELATIVE TO NON-MEDITATORS ACROSS THE WHOLE BRAIN. IN ADDITION, GREY MATTER VOLUME WAS LARGER IN SEVERAL PREDOMINANTLY RIGHT HEMISPHERIC REGIONS: IN INSULA, VENTROMEDIAL ORBITOFRONTAL CORTEX, INFERIOR TEMPORAL AND PARIETAL CORTICES AS WELL AS IN LEFT VENTROLATERAL PREFRONTAL CORTEX AND LEFT INSULA. NO AREAS WITH LARGER GREY MATTER VOLUME WERE FOUND IN NON-MEDITATORS RELATIVE TO MEDITATORS. CONCLUSIONS: THE STUDY SHOWS THAT LONG-TERM PRACTICE OF SAHAJA YOGA MEDITATION IS ASSOCIATED WITH LARGER GREY MATTER VOLUME OVERALL, AND WITH REGIONAL ENLARGEMENT IN SEVERAL RIGHT HEMISPHERIC CORTICAL AND SUBCORTICAL BRAIN REGIONS THAT ARE ASSOCIATED WITH SUSTAINED ATTENTION, SELF-CONTROL, COMPASSION AND INTEROCEPTIVE PERCEPTION. THE INCREASED GREY MATTER VOLUME IN THESE ATTENTION AND SELF-CONTROL MEDIATING REGIONS SUGGESTS USE-DEPENDENT ENLARGEMENT WITH REGULAR PRACTICE OF THIS MEDITATION. 2016 5 1496 30 INTRACEREBRAL PAIN PROCESSING IN A YOGA MASTER WHO CLAIMS NOT TO FEEL PAIN DURING MEDITATION. WE RECORDED MAGNETOENCEPHALOGRAPHY (MEG) AND FUNCTIONAL MAGNETIC RESONANCE IMAGING (FMRI) FOLLOWING NOXIOUS LASER STIMULATION IN A YOGA MASTER WHO CLAIMS NOT TO FEEL PAIN WHEN MEDITATING. AS FOR BACKGROUND MEG ACTIVITY, THE POWER OF ALPHA FREQUENCY BANDS PEAKING AT AROUND 10 HZ WAS MUCH INCREASED DURING MEDITATION OVER OCCIPITAL, PARIETAL AND TEMPORAL REGIONS, WHEN COMPARED WITH THE NON-MEDITATIVE STATE, WHICH MIGHT MEAN THE SUBJECT WAS VERY RELAXED, THOUGH HE DID NOT FALL ASLEEP, DURING MEDITATION. PRIMARY PAIN-RELATED CORTICAL ACTIVITIES RECORDED FROM PRIMARY (SI) AND SECONDARY SOMATOSENSORY CORTICES (SII) BY MEG WERE VERY WEAK OR ABSENT DURING MEDITATION. AS FOR FMRI RECORDING, THERE WERE REMARKABLE CHANGES IN LEVELS OF ACTIVITY IN THE THALAMUS, SII-INSULA (MAINLY THE INSULA) AND CINGULATE CORTEX BETWEEN MEDITATION AND NON-MEDITATION. ACTIVITIES IN ALL THREE REGIONS WERE INCREASED DURING NON-MEDITATION, SIMILAR TO RESULTS IN NORMAL SUBJECTS. IN CONTRAST, ACTIVITIES IN ALL THREE REGIONS WERE WEAKER DURING MEDITATION, AND THE LEVEL WAS LOWER THAN THE BASELINE IN THE THALAMUS. RECENT NEUROIMAGING AND ELECTROPHYSIOLOGICAL STUDIES HAVE CLARIFIED THAT THE EMOTIONAL ASPECT OF PAIN PERCEPTION MAINLY INVOLVES THE INSULA AND CINGULATE CORTEX. THOUGH WE CANNOT CLEARLY EXPLAIN THIS UNUSUAL CONDITION IN THE YOGA MASTER, A CHANGE OF MULTIPLE REGIONS RELATING TO PAIN PERCEPTION COULD BE RESPONSIBLE, SINCE PAIN IS A COMPLEX SENSORY AND EMOTIONAL EXPERIENCE. 2005 6 2254 34 THE ORIGIN AND CLINICAL RELEVANCE OF YOGA NIDRA. YOGA NIDRA, ALSO KNOWN AS 'YOGIC SLEEP', IS A SIMPLIFIED FORM OF AN ANCIENT TANTRIC RELAXATION TECHNIQUE. THE MOST GENERAL DESCRIPTION OF THE PRACTICE IS THAT IT COMBINES GUIDED MENTAL IMAGERY WITH A SPECIFIC YOGA POSTURE CALLED SHAVASANA (OR "CORPSE POSE"). THE GOAL OF YOGA NIDRA IS TO PROMOTE A PROFOUND STATE OF RELAXATION, WHICH DIFFERS FROM SLEEP INASMUCH AS THERE IS STILL AN AWARENESS OF ONE'S SURROUNDINGS. WHILE SEVERAL COMPONENTS OF THE PRACTICE HAVE BEEN KNOWN SINCE ANCIENT TIMES, IT WAS NOT UNTIL THE 1960S THAT AN UPDATED AND SYSTEMATIZED SYSTEM OF PRACTICE WAS INTRODUCED TO THE PUBLIC THROUGH THE WRITINGS OF SWAMI SATYANANDA SARASWATI. UNLIKE OTHER SCHOOLS OF YOGA, WHICH EMPHASIZE CONCENTRATION OR CONTEMPLATION, YOGA NIDRA'S GOAL IS COMPLETE RELAXATION. AS SUCH, ITS ADVOCATES CLAIM THAT IT IS SUITABLE FOR ALL INDIVIDUALS, FROM BEGINNERS TO ADVANCED PRACTITIONERS OF YOGA. THE CALM INNER STILLNESS INDUCED BY YOGA NIDRA IS CLAIMED BY PRACTITIONERS TO BE AN EFFECTIVE STRESS MANAGEMENT TOOL AS WELL AS A MEANS FOR ATTAINING GREATER RECEPTIVITY TO PERSONAL RESOLUTIONS. THESE RESOLUTIONS CAN RANGE FROM THE GOAL OF ACHIEVING SELF-TRANSFORMATION, ENHANCING CREATIVITY, OR IMPROVING ONE'S LEARNING ABILITY. ADDITIONALLY, YOGA NIDRA IS CLAIMED TO PROMOTE BENEFICIAL CHANGES IN PHYSIOLOGICAL AND MENTAL HEALTH. THE FOLLOWING NARRATIVE REVIEW SUMMARIZES THE BASIC STEPS USED TO ACHIEVE THE FINAL STATE OF YOGA NIDRA RELAXATION AS WELL AS SOME RECENT EXPERIMENTAL FINDINGS REGARDING ITS PHYSIOLOGICAL AND PSYCHOLOGICAL EFFECTS. STANDARD RESEARCH DATABASES WERE SEARCHED FOR RELEVANT ARTICLES. CLINICAL STUDIES HAVE SHOWN THAT YOGA NIDRA MEDITATION IS ASSOCIATED WITH POSITIVE PHYSIOLOGICAL CHANGES, INCLUDING IMPROVEMENTS IN SEVERAL HEMATOLOGICAL VARIABLES, RED BLOOD CELL COUNTS, BLOOD GLUCOSE LEVELS, AND HORMONAL STATUS. TWO NEUROIMAGING STUDIES HAVE SHOWN THAT YOGA NIDRA PRODUCES CHANGES IN ENDOGENOUS DOPAMINE RELEASE AND CEREBRAL BLOOD FLOW, A FURTHER CONFIRMATION THAT ITS EFFECTS ON THE CNS ARE OBJECTIVELY MEASURABLE. THE PRACTICE HAS ALSO BEEN SHOWN TO REDUCE PSYCHOMETRICALLY MEASURED INDICES OF MILD DEPRESSION AND ANXIETY, ALTHOUGH THESE BENEFITS WERE NOT SHOWN IN AN EXPERIMENTAL STUDY TO EXTEND TO SEVERE DEPRESSION OR SEVERE ANXIETY. 2022 7 1286 31 GRAY MATTER AND FUNCTIONAL CONNECTIVITY IN ANTERIOR CINGULATE CORTEX ARE ASSOCIATED WITH THE STATE OF MENTAL SILENCE DURING SAHAJA YOGA MEDITATION. SOME MEDITATION TECHNIQUES TEACH THE PRACTITIONER TO ACHIEVE THE STATE OF MENTAL SILENCE. THE AIM OF THIS STUDY WAS TO INVESTIGATE BRAIN REGIONS THAT ARE ASSOCIATED WITH THEIR VOLUME AND FUNCTIONAL CONNECTIVITY (FC) WITH THE DEPTH OF MENTAL SILENCE IN LONG-TERM PRACTITIONERS OF SAHAJA YOGA MEDITATION. TWENTY-THREE LONG-TERM PRACTITIONERS OF THIS MEDITATION WERE SCANNED USING MAGNETIC RESONANCE IMAGING. IN ORDER TO IDENTIFY THE NEURAL CORRELATES OF THE DEPTH OF MENTAL SILENCE, WE TESTED WHICH GRAY MATTER VOLUMES (GMV) WERE CORRELATED WITH THE DEPTH OF MENTAL SILENCE AND WHICH REGIONS THESE AREAS WERE FUNCTIONALLY CONNECTED TO UNDER A MEDITATION CONDITION. GMV IN MEDIAL PREFRONTAL CORTEX INCLUDING ROSTRAL ANTERIOR CINGULATE CORTEX WERE POSITIVELY CORRELATED WITH THE SUBJECTIVE PERCEPTION OF THE DEPTH OF MENTAL SILENCE INSIDE THE SCANNER. FURTHERMORE, THERE WAS SIGNIFICANTLY INCREASED FC BETWEEN THIS AREA AND BILATERAL ANTERIOR INSULA/PUTAMEN DURING A MEDITATION-STATE SPECIFICALLY, WHILE DECREASED CONNECTIVITY WITH THE RIGHT THALAMUS/PARAHIPPOCAMPAL GYRUS WAS PRESENT DURING THE MEDITATION-STATE AND THE RESTING-STATE. THE CAPACITY OF LONG-TERM MEDITATORS TO ESTABLISH A DURABLE STATE OF MENTAL SILENCE INSIDE AN MRI SCANNER WAS ASSOCIATED WITH LARGER GRAY MATTER VOLUME IN A MEDIAL FRONTAL REGION THAT IS CRUCIAL FOR TOP-DOWN COGNITIVE, EMOTION AND ATTENTION CONTROL. THIS IS FURTHERMORE CORROBORATED BY INCREASED FC OF THIS REGION DURING THE MEDITATION-STATE WITH BILATERAL ANTERIOR INSULA/PUTAMEN, WHICH ARE IMPORTANT FOR INTEROCEPTION, EMOTION, AND ATTENTION REGULATION. THE FINDINGS HENCE SUGGEST THAT THE DEPTH OF MENTAL SILENCE IS ASSOCIATED WITH MEDIAL FRONTO-INSULAR-STRIATAL NETWORKS THAT ARE CRUCIAL FOR TOP-DOWN ATTENTION AND EMOTIONAL CONTROL. 2018 8 1641 19 MONITORING THE NEURAL ACTIVITY OF THE STATE OF MENTAL SILENCE WHILE PRACTICING SAHAJA YOGA MEDITATION. OBJECTIVE: TO IDENTIFY THE NEURAL CORRELATES OF THE STATE OF MENTAL SILENCE AS EXPERIENCED THROUGH SAHAJA YOGA MEDITATION. DESIGN: NINETEEN EXPERIENCED MEDITATORS UNDERWENT FUNCTIONAL MAGNETIC RESONANCE IMAGING DURING THREE SHORT CONSECUTIVE MEDITATION PERIODS, CONTRASTED WITH A CONTROL RELAXATION CONDITION. RESULTS: RELATIVE TO BASELINE, AT THE BEGINNING OF THE MEDITATION SESSIONS THERE WAS A SIGNIFICANT INCREASE OF ACTIVATION IN BILATERAL INFERIOR FRONTAL AND TEMPORAL REGIONS. ACTIVATION BECAME PROGRESSIVELY MORE REDUCED WITH DEEPER MEDITATION STAGES AND IN THE LAST MEDITATION SESSION IT BECAME LOCALIZED TO THE RIGHT INFERIOR FRONTAL CORTEX/ RIGHT INSULA AND RIGHT MIDDLE/SUPERIOR TEMPORAL CORTEX. FURTHERMORE, RIGHT INFERIOR FRONTAL ACTIVATION WAS DIRECTLY ASSOCIATED WITH THE SUBJECTIVE DEPTH OF THE MENTAL SILENCE EXPERIENCE. CONCLUSIONS: MEDITATORS APPEAR TO PASS THROUGH AN INITIAL INTENSE NEURAL SELF-CONTROL PROCESS NECESSARY TO SILENCE THEIR MIND. AFTER THIS THEY EXPERIENCE RELATIVELY REDUCED BRAIN ACTIVATION CONCOMITANT WITH THE DEEPENING OF THE STATE OF MENTAL SILENCE OVER RIGHT INFERIOR FRONTAL CORTEX, PROBABLY REFLECTING AN EFFORTLESS PROCESS OF ATTENTIONAL CONTEMPLATION ASSOCIATED WITH THIS STATE. 2015 9 76 24 A HEURISTIC MODEL LINKING YOGA PHILOSOPHY AND SELF-REFLECTION TO EXAMINE UNDERLYING MECHANISMS OF ADD-ON YOGA TREATMENT IN SCHIZOPHRENIA. PRELIMINARY EVIDENCE SUGGESTS EFFICACY OF YOGA AS ADD-ON TREATMENT FOR SCHIZOPHRENIA, BUT THE UNDERLYING MECHANISM BY WHICH YOGA IMPROVES THE SYMPTOMS OF SCHIZOPHRENIA IS NOT COMPLETELY UNDERSTOOD. YOGA IMPROVES SELF-REFLECTION IN HEALTHY INDIVIDUALS, AND SELF-REFLECTION ABNORMALITIES ARE TYPICALLY SEEN IN SCHIZOPHRENIA. HOWEVER, WHETHER YOGA TREATMENT IMPROVES IMPAIRMENTS IN SELF-REFLECTION TYPICALLY SEEN IN PATIENTS WITH SCHIZOPHRENIA IS NOT EXAMINED. THIS PAPER DISCUSSES THE POTENTIAL MECHANISM OF YOGA IN THE TREATMENT OF SCHIZOPHRENIA AND PROPOSES A TESTABLE HYPOTHESIS FOR FURTHER EMPIRICAL STUDIES. IT IS PROPOSED THAT SELF-REFLECTION ABNORMALITIES IN SCHIZOPHRENIA IMPROVE WITH YOGA AND THE NEUROBIOLOGICAL CHANGES ASSOCIATED WITH THIS CAN BE EXAMINED USING EMPIRICAL BEHAVIOURAL MEASURES AND NEUROIMAGING MEASURES SUCH AS MAGNETIC RESONANCE IMAGING. 2016 10 2531 37 YOGA EFFECTS ON BRAIN HEALTH: A SYSTEMATIC REVIEW OF THE CURRENT LITERATURE. YOGA IS THE MOST POPULAR COMPLEMENTARY HEALTH APPROACH PRACTICED BY ADULTS IN THE UNITED STATES. IT IS AN ANCIENT MIND AND BODY PRACTICE WITH ORIGINS IN INDIAN PHILOSOPHY. YOGA COMBINES PHYSICAL POSTURES, RHYTHMIC BREATHING AND MEDITATIVE EXERCISE TO OFFER THE PRACTITIONERS A UNIQUE HOLISTIC MIND-BODY EXPERIENCE. WHILE THE HEALTH BENEFITS OF PHYSICAL EXERCISE ARE WELL ESTABLISHED, IN RECENT YEARS, THE ACTIVE ATTENTIONAL COMPONENT OF BREATHING AND MEDITATION PRACTICE HAS GARNERED INTEREST AMONG EXERCISE NEUROSCIENTISTS. AS THE SCIENTIFIC EVIDENCE FOR THE PHYSICAL AND MENTAL HEALTH BENEFITS OF YOGA CONTINUES TO GROW, THIS ARTICLE AIMS TO SUMMARIZE THE CURRENT KNOWLEDGE OF YOGA PRACTICE AND ITS DOCUMENTED POSITIVE EFFECTS FOR BRAIN STRUCTURE AND FUNCTION, AS ASSESSED WITH MRI, FMRI, AND SPECT. WE REVIEWED 11 STUDIES EXAMINING THE EFFECTS OF YOGA PRACTICE ON THE BRAIN STRUCTURES, FUNCTION AND CEREBRAL BLOOD FLOW. COLLECTIVELY, THE STUDIES DEMONSTRATE A POSITIVE EFFECT OF YOGA PRACTICE ON THE STRUCTURE AND/OR FUNCTION OF THE HIPPOCAMPUS, AMYGDALA, PREFRONTAL CORTEX, CINGULATE CORTEX AND BRAIN NETWORKS INCLUDING THE DEFAULT MODE NETWORK (DMN). THE STUDIES OFFER PROMISING EARLY EVIDENCE THAT BEHAVIORAL INTERVENTIONS LIKE YOGA MAY HOLD PROMISE TO MITIGATE AGE-RELATED AND NEURODEGENERATIVE DECLINES AS MANY OF THE REGIONS IDENTIFIED ARE KNOWN TO DEMONSTRATE SIGNIFICANT AGE-RELATED ATROPHY. 2019 11 1472 32 INSULAR CORTEX MEDIATES INCREASED PAIN TOLERANCE IN YOGA PRACTITIONERS. YOGA, AN INCREASINGLY POPULAR DISCIPLINE AMONG WESTERNERS, IS FREQUENTLY USED TO IMPROVE PAINFUL CONDITIONS. WE INVESTIGATED POSSIBLE NEUROANATOMICAL UNDERPINNINGS OF THE BENEFICIAL EFFECTS OF YOGA USING SENSORY TESTING AND MAGNETIC RESONANCE IMAGING TECHNIQUES. NORTH AMERICAN YOGIS TOLERATED PAIN MORE THAN TWICE AS LONG AS INDIVIDUALLY MATCHED CONTROLS AND HAD MORE GRAY MATTER (GM) IN MULTIPLE BRAIN REGIONS. ACROSS SUBJECTS, INSULAR GM UNIQUELY CORRELATED WITH PAIN TOLERANCE. INSULAR GM VOLUME IN YOGIS POSITIVELY CORRELATED WITH YOGA EXPERIENCE, SUGGESTING A CAUSAL RELATIONSHIP BETWEEN YOGA AND INSULAR SIZE. YOGIS ALSO HAD INCREASED LEFT INTRAINSULAR WHITE MATTER INTEGRITY, CONSISTENT WITH A STRENGTHENED INSULAR INTEGRATION OF NOCICEPTIVE INPUT AND PARASYMPATHETIC AUTONOMIC REGULATION. YOGIS, AS OPPOSED TO CONTROLS, USED COGNITIVE STRATEGIES INVOLVING PARASYMPATHETIC ACTIVATION AND INTEROCEPTIVE AWARENESS TO TOLERATE PAIN, WHICH COULD HAVE LED TO USE-DEPENDENT HYPERTROPHY OF INSULAR CORTEX. TOGETHER, THESE FINDINGS SUGGEST THAT REGULAR AND LONG-TERM YOGA PRACTICE IMPROVES PAIN TOLERANCE IN TYPICAL NORTH AMERICANS BY TEACHING DIFFERENT WAYS TO DEAL WITH SENSORY INPUTS AND THE POTENTIAL EMOTIONAL REACTIONS ATTACHED TO THOSE INPUTS LEADING TO A CHANGE IN INSULAR BRAIN ANATOMY AND CONNECTIVITY. 2014 12 1670 29 NEUROPROTECTIVE EFFECTS OF YOGA PRACTICE: AGE-, EXPERIENCE-, AND FREQUENCY-DEPENDENT PLASTICITY. YOGA COMBINES POSTURES, BREATHING, AND MEDITATION. DESPITE REPORTED HEALTH BENEFITS, YOGA'S EFFECTS ON THE BRAIN HAVE RECEIVED LITTLE STUDY. WE USED MAGNETIC RESONANCE IMAGING TO COMPARE AGE-RELATED GRAY MATTER (GM) DECLINE IN YOGIS AND CONTROLS. WE ALSO EXAMINED THE EFFECT OF INCREASING YOGA EXPERIENCE AND WEEKLY PRACTICE ON GM VOLUME AND ASSESSED WHICH ASPECTS OF WEEKLY PRACTICE CONTRIBUTED MOST TO BRAIN SIZE. CONTROLS DISPLAYED THE WELL DOCUMENTED AGE-RELATED GLOBAL BRAIN GM DECLINE WHILE YOGIS DID NOT, SUGGESTING THAT YOGA CONTRIBUTES TO PROTECT THE BRAIN AGAINST AGE-RELATED DECLINE. YEARS OF YOGA EXPERIENCE CORRELATED MOSTLY WITH GM VOLUME DIFFERENCES IN THE LEFT HEMISPHERE (INSULA, FRONTAL OPERCULUM, AND ORBITOFRONTAL CORTEX) SUGGESTING THAT YOGA TUNES THE BRAIN TOWARD A PARASYMPATICALLY DRIVEN MODE AND POSITIVE STATES. THE NUMBER OF HOURS OF WEEKLY PRACTICE CORRELATED WITH GM VOLUME IN THE PRIMARY SOMATOSENSORY CORTEX/SUPERIOR PARIETAL LOBULE (S1/SPL), PRECUNEUS/POSTERIOR CINGULATE CORTEX (PCC), HIPPOCAMPUS, AND PRIMARY VISUAL CORTEX (V1). COMMONALITY ANALYSES INDICATED THAT THE COMBINATION OF POSTURES AND MEDITATION CONTRIBUTED THE MOST TO THE SIZE OF THE HIPPOCAMPUS, PRECUNEUS/PCC, AND S1/SPL WHILE THE COMBINATION OF MEDITATION AND BREATHING EXERCISES CONTRIBUTED THE MOST TO V1 VOLUME. YOGA'S POTENTIAL NEUROPROTECTIVE EFFECTS MAY PROVIDE A NEURAL BASIS FOR SOME OF ITS BENEFICIAL EFFECTS. 2015 13 1897 30 RESTING STATE FUNCTIONAL CONNECTIVITY ASSOCIATED WITH SAHAJA YOGA MEDITATION. NEUROSCIENCE RESEARCH HAS SHOWN THAT MEDITATION PRACTICES HAVE EFFECTS ON BRAIN STRUCTURE AND FUNCTION. HOWEVER, FEW STUDIES HAVE COMBINED INFORMATION ON THE EFFECTS ON STRUCTURE AND FUNCTION IN THE SAME SAMPLE. LONG-TERM DAILY MEDITATION PRACTICE PRODUCES REPEATED ACTIVITY OF SPECIFIC BRAIN NETWORKS OVER YEARS OF PRACTICE, WHICH MAY INDUCE LASTING STRUCTURAL AND FUNCTIONAL CONNECTIVITY (FC) CHANGES WITHIN RELEVANT CIRCUITS. THE AIM OF OUR STUDY WAS THEREFORE TO IDENTIFY DIFFERENCES IN FC DURING THE RESTING STATE BETWEEN 23 SAHAJA YOGA MEDITATION EXPERTS AND 23 HEALTHY PARTICIPANTS WITHOUT MEDITATION EXPERIENCE. SEED-BASED FC ANALYSIS WAS PERFORMED DEPARTING FROM VOXELS THAT HAD SHOWN STRUCTURAL DIFFERENCES BETWEEN THESE SAME PARTICIPANTS. THE CONTRAST OF CONNECTIVITY MAPS YIELDED THAT MEDITATORS SHOWED INCREASED FC BETWEEN THE LEFT VENTROLATERAL PREFRONTAL CORTEX AND THE RIGHT DORSOLATERAL PREFRONTAL CORTEX BUT REDUCED FC BETWEEN THE LEFT INSULA AND THE BILATERAL MID-CINGULATE AS WELL AS BETWEEN THE RIGHT ANGULAR GYRUS AND THE BILATERAL PRECUNEUS/CUNEUS CORTICES. IT THUS APPEARS THAT LONG-TERM MEDITATION PRACTICE INCREASES DIRECT FC BETWEEN VENTRAL AND DORSAL FRONTAL REGIONS WITHIN BRAIN NETWORKS RELATED TO ATTENTION AND COGNITIVE CONTROL AND DECREASES FC BETWEEN REGIONS OF THESE NETWORKS AND AREAS OF THE DEFAULT MODE NETWORK. 2021 14 1545 30 LARGER WHOLE BRAIN GREY MATTER ASSOCIATED WITH LONG-TERM SAHAJA YOGA MEDITATION: A DETAILED AREA BY AREA COMPARISON. OBJECTIVES: OUR PREVIOUS STUDY SHOWED THAT LONG-TERM PRACTITIONERS OF SAHAJA YOGA MEDITATION (SYM) HAD AROUND 7% LARGER GREY MATTER VOLUME (GMV) IN THE WHOLE BRAIN COMPARED WITH HEALTHY CONTROLS; HOWEVER, WHEN TESTING INDIVIDUAL REGIONS, ONLY 5 SMALL BRAIN AREAS WERE STATISTICALLY DIFFERENT BETWEEN GROUPS. UNDER THE HYPOTHESIS THAT THOSE RESULTS WERE STATISTICALLY CONSERVATIVE, WITH THE SAME DATASET, WE INVESTIGATED IN MORE DETAIL THE REGIONAL DIFFERENCES IN GMV ASSOCIATED WITH THE PRACTICE OF SYM, WITH A DIFFERENT STATISTICAL APPROACH. DESIGN: TWENTY-THREE EXPERIENCED PRACTITIONERS OF SYM AND 23 HEALTHY NON-MEDITATORS MATCHED ON AGE, SEX AND EDUCATION LEVEL, WERE SCANNED USING STRUCTURAL MAGNETIC RESONANCE IMAGING (MRI). THEIR GMV WERE EXTRACTED AND COMPARED USING VOXEL-BASED MORPHOMETRY (VBM). USING A NOVEL AD-HOC GENERAL LINEAR MODEL, STATISTICAL COMPARISONS WERE MADE TO OBSERVE IF THE GMV DIFFERENCES BETWEEN MEDITATORS AND CONTROLS WERE STATISTICALLY SIGNIFICANT. RESULTS: IN THE 16 LOBE AREA SUBDIVISIONS, GMV WAS STATISTICALLY SIGNIFICANTLY DIFFERENT IN 4 OUT OF 16 AREAS: IN RIGHT HEMISPHERIC TEMPORAL AND FRONTAL LOBES, LEFT FRONTAL LOBE AND BRAINSTEM. IN THE 116 AAL AREA SUBDIVISIONS, GMV DIFFERENCE WAS STATISTICALLY SIGNIFICANT IN 11 AREAS. THE GMV DIFFERENCES WERE STATISTICALLY MORE SIGNIFICANT IN RIGHT HEMISPHERIC BRAIN AREAS. CONCLUSIONS: THE STUDY SHOWS THAT LONG-TERM PRACTICE OF SYM IS ASSOCIATED WITH LARGER GMV OVERALL, AND WITH SIGNIFICANT DIFFERENCES MAINLY IN TEMPORAL AND FRONTAL AREAS OF THE RIGHT HEMISPHERE AND THE BRAINSTEM. THESE NEUROPLASTIC CHANGES MAY REFLECT EMOTIONAL AND ATTENTIONAL CONTROL MECHANISMS DEVELOPED WITH SYM. ON THE OTHER HAND, OUR STATISTICAL AD-HOC METHOD SHOWS THAT THERE WERE MORE BRAIN AREAS WITH STATISTICAL SIGNIFICANCE COMPARED TO THE TRADITIONAL METHODOLOGY WHICH WE THINK IS SUSCEPTIBLE TO CONSERVATIVE TYPE II ERRORS. 2020 15 916 19 EFFECTIVENESS OF SOMATIC YOGA AND MEDITATION: A PILOT STUDY IN A MULTICULTURAL CANCER SURVIVOR POPULATION WITH CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY. CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY (CIPN) CAUSES SIGNIFICANT PAIN AND IS AN ADVERSE EFFECT OF TREATMENT WITH CHEMOTHERAPEUTIC AGENTS. WE EXPLORED A SOMATIC YOGA AND MEDITATION INTERVENTION IN A PREDOMINANTLY MINORITY POPULATION. GOALS INCLUDED DESCRIBING STRATEGIES FOR MINORITY INCLUSION AND TESTING FEASIBILITY AND EFFECTIVENESS. EIGHT INDIVIDUALS WITH CIPN ENROLLED IN A SINGLE-ARM FEASIBILITY TRIAL. SOMATIC YOGA AND MEDITATION WERE PROVIDED WEEKLY FOR 8 WEEKS, WITH AN ADDITIONAL HOME PROGRAM COMPONENT. THE PRIMARY OUTCOMES WERE SIT AND REACH, FUNCTIONAL REACH, AND TIMED UP AND GO. SECONDARY OUTCOMES WERE PATIENT NEUROTOXICITY QUESTIONNAIRE, FACT-GOG-NTX (FOR ADDRESSING PATIENT CONCERNS ASSOCIATED WITH NEUROLOGICAL SYMPTOMS), BRIEF PAIN INVENTORY, PERCEIVED STRESS SCALE, PITTSBURGH SLEEP QUALITY INDEX, AND FALLS EFFICACY SCALE. SENSITIVITY TO VIBRATION WAS MEASURED VIA BIOTHESIOMETER. PARTICIPANTS WITH A MEAN AGE OF 65 (49-73) YEARS SELF-REPORTED AS 63% AFRICAN-AMERICAN AND 37% CAUCASIAN. THEY ATTENDED 81% OF THE SESSIONS, AND NO ADVERSE EVENTS WE RE RE P O RTED. CIPN SYMPTOMS (FAC T- G O G - N T X ) IMPROVED SIGNIFICANTLY (FROM 88.88 TO 106.88, STANDARD DEVIATION = 20.03; P = 0.039). FEAR OF FALLING IMPROVED, APPROACHING SIGNIFICANCE (FROM 39.26 TO 34.38, STANDARD DEVIATION = 6.081; P = 0.058). OTHER MEASURES SHOWED IMPROVEMENT TRENDS, WITH A SLIGHT INCREASE IN BRIEF PAIN INVENTORY PAIN SEVERITY (FROM 3.50 TO 3.75, P = 0.041) POSSIBLY REFLECTING COMORBIDITIES. FOUR QUALITATIVE THEMES EMERGED: (1) CIPN SYMPTOM VARIABILITY, WITH MUSCULOSKELETAL COMORBIDITIES; (2) UTILITY OF LEARNED SKILLS; (3) IMPROVEMENT IN SELF-CONFIDENCE, BALANCE, AND STABILITY; AND (4) SOCIAL SUPPORT, WITH CIPN EXPERIENCE VALIDATION AND INCREASING HEALTH LITERACY. CHALLENGES OF RECRUITMENT AND RETENTION REQUIRE SPECIFIC OUTREACH, COMMUNITY TRUST, AND HEALTH LITERACY. PRELIMINARY DATA SUGGEST THAT SOMATIC YOGA AND MEDITATION MAY AFFECT FEAR OF FALLING AND QUALITY OF LIFE IN CANCER SURVIVORS WITH CIPN. A RANDOMIZED CONTROLLED TRIAL USING INCLUSIVE RECRUITMENT AND RETENTION METHODS IS INDICATED TO ESTABLISH THE INTERVENTION'S EFFICACY. 2020 16 571 21 DEFINING YOGA-NIDRA: TRADITIONAL ACCOUNTS, PHYSIOLOGICAL RESEARCH, AND FUTURE DIRECTIONS. THE TERM YOGA-NIDRA HAS BEEN USED IN MANY EMPIRICAL STUDIES TO REFER TO RELAXATION AND GUIDED IMAGERY. THESE TECHNIQUES DO NOT REPRESENT THE INTENTION OR PHYSIOLOGICAL CORRELATES OF YOGANIDRA DISCUSSED IN THE TRADITIONAL YOGA LITERATURE. WE PROPOSE AN OPERATIONAL DEFINITION OF YOGA-NIDRA THAT IS SUPPORTED BY SEVERAL PHYSIOLOGICALLY TESTABLE HYPOTHESES REGARDING ITS OUTCOMES AND EFFECTS. TRADITIONAL DESCRIPTIONS OF YOGA-NIDRA AND CONTEMPORARY ACCOUNTS OF ITS PRACTICE ARE REVIEWED, AND STUDIES EXAMINING THE PHYSIOLOGICAL CORRELATES OF YOGA-NIDRA ARE EXAMINED. PROPOSED HYPOTHESES FOR FUTURE RESEARCH USING THIS OPERATIONAL DEFINITION ARE PROVIDED. 2013 17 455 27 CHANGES IN NEURAL CONNECTIVITY AND MEMORY FOLLOWING A YOGA INTERVENTION FOR OLDER ADULTS: A PILOT STUDY. BACKGROUND: NO STUDY HAS EXPLORED THE EFFECT OF YOGA ON COGNITIVE DECLINE AND RESTING-STATE FUNCTIONAL CONNECTIVITY. OBJECTIVES: THIS STUDY EXPLORED THE RELATIONSHIP BETWEEN PERFORMANCE ON MEMORY TESTS AND RESTING-STATE FUNCTIONAL CONNECTIVITY BEFORE AND AFTER A YOGA INTERVENTION VERSUS ACTIVE CONTROL FOR SUBJECTS WITH MILD COGNITIVE IMPAIRMENT (MCI). METHODS: PARTICIPANTS ( >/= 55 Y) WITH MCI WERE RANDOMIZED TO RECEIVE A YOGA INTERVENTION OR ACTIVE "GOLD-STANDARD" CONTROL (I.E., MEMORY ENHANCEMENT TRAINING (MET)) FOR 12 WEEKS. RESTING-STATE FUNCTIONAL MAGNETIC RESONANCE IMAGING WAS USED TO MAP CORRELATIONS BETWEEN BRAIN NETWORKS AND MEMORY PERFORMANCE CHANGES OVER TIME. DEFAULT MODE NETWORKS (DMN), LANGUAGE AND SUPERIOR PARIETAL NETWORKS WERE CHOSEN AS NETWORKS OF INTEREST TO ANALYZE THE ASSOCIATION WITH CHANGES IN VERBAL AND VISUOSPATIAL MEMORY PERFORMANCE. RESULTS: FOURTEEN YOGA AND 11 MET PARTICIPANTS COMPLETED THE STUDY. THE YOGA GROUP DEMONSTRATED A STATISTICALLY SIGNIFICANT IMPROVEMENT IN DEPRESSION AND VISUOSPATIAL MEMORY. WE OBSERVED IMPROVED VERBAL MEMORY PERFORMANCE CORRELATED WITH INCREASED CONNECTIVITY BETWEEN THE DMN AND FRONTAL MEDIAL CORTEX, PREGENUAL ANTERIOR CINGULATE CORTEX, RIGHT MIDDLE FRONTAL CORTEX, POSTERIOR CINGULATE CORTEX, AND LEFT LATERAL OCCIPITAL CORTEX. IMPROVED VERBAL MEMORY PERFORMANCE POSITIVELY CORRELATED WITH INCREASED CONNECTIVITY BETWEEN THE LANGUAGE PROCESSING NETWORK AND THE LEFT INFERIOR FRONTAL GYRUS. IMPROVED VISUOSPATIAL MEMORY PERFORMANCE CORRELATED INVERSELY WITH CONNECTIVITY BETWEEN THE SUPERIOR PARIETAL NETWORK AND THE MEDIAL PARIETAL CORTEX. CONCLUSION: YOGA MAY BE AS EFFECTIVE AS MET IN IMPROVING FUNCTIONAL CONNECTIVITY IN RELATION TO VERBAL MEMORY PERFORMANCE. THESE FINDINGS SHOULD BE CONFIRMED IN LARGER PROSPECTIVE STUDIES. 2016 18 93 27 A NARRATIVE REVIEW OF YOGA AND MINDFULNESS AS COMPLEMENTARY THERAPIES FOR ADDICTION. THIS PAPER REVIEWS THE PHILOSOPHICAL ORIGINS, CURRENT SCIENTIFIC EVIDENCE, AND CLINICAL PROMISE OF YOGA AND MINDFULNESS AS COMPLEMENTARY THERAPIES FOR ADDICTION. HISTORICALLY, THERE ARE EIGHT ELEMENTS OF YOGA THAT, TOGETHER, COMPRISE ETHICAL PRINCIPLES AND PRACTICES FOR LIVING A MEANINGFUL, PURPOSEFUL, MORAL AND SELF-DISCIPLINED LIFE. TRADITIONAL YOGA PRACTICES, INCLUDING POSTURES AND MEDITATION, DIRECT ATTENTION TOWARD ONE'S HEALTH, WHILE ACKNOWLEDGING THE SPIRITUAL ASPECTS OF ONE'S NATURE. MINDFULNESS DERIVES FROM ANCIENT BUDDHIST PHILOSOPHY, AND MINDFULNESS MEDITATION PRACTICES, SUCH AS GENTLE HATHA YOGA AND MINDFUL BREATHING, ARE INCREASINGLY INTEGRATED INTO SECULAR HEALTH CARE SETTINGS. CURRENT THEORETICAL MODELS SUGGEST THAT THE SKILLS, INSIGHTS, AND SELF-AWARENESS LEARNED THROUGH YOGA AND MINDFULNESS PRACTICE CAN TARGET MULTIPLE PSYCHOLOGICAL, NEURAL, PHYSIOLOGICAL, AND BEHAVIORAL PROCESSES IMPLICATED IN ADDICTION AND RELAPSE. A SMALL BUT GROWING NUMBER OF WELL-DESIGNED CLINICAL TRIALS AND EXPERIMENTAL LABORATORY STUDIES ON SMOKING, ALCOHOL DEPENDENCE, AND ILLICIT SUBSTANCE USE SUPPORT THE CLINICAL EFFECTIVENESS AND HYPOTHESIZED MECHANISMS OF ACTION UNDERLYING MINDFULNESS-BASED INTERVENTIONS FOR TREATING ADDICTION. BECAUSE VERY FEW STUDIES HAVE BEEN CONDUCTED ON THE SPECIFIC ROLE OF YOGA IN TREATING OR PREVENTING ADDICTION, WE PROPOSE A CONCEPTUAL MODEL TO INFORM FUTURE STUDIES ON OUTCOMES AND POSSIBLE MECHANISMS. ADDITIONAL RESEARCH IS ALSO NEEDED TO BETTER UNDERSTAND WHAT TYPES OF YOGA AND MINDFULNESS-BASED INTERVENTIONS WORK BEST FOR WHAT TYPES OF ADDICTION, WHAT TYPES OF PATIENTS, AND UNDER WHAT CONDITIONS. OVERALL, CURRENT FINDINGS INCREASINGLY SUPPORT YOGA AND MINDFULNESS AS PROMISING COMPLEMENTARY THERAPIES FOR TREATING AND PREVENTING ADDICTIVE BEHAVIORS. 2013 19 1098 29 EFFECTS OF YOGA RESPIRATORY PRACTICE (BHASTRIKA PRANAYAMA) ON ANXIETY, AFFECT, AND BRAIN FUNCTIONAL CONNECTIVITY AND ACTIVITY: A RANDOMIZED CONTROLLED TRIAL. PRANAYAMA REFERS TO A SET OF YOGA BREATHING EXERCISES. RECENT EVIDENCE SUGGESTS THAT THE PRACTICE OF PRANAYAMA HAS POSITIVE EFFECTS ON MEASURES OF CLINICAL STRESS AND ANXIETY. THIS STUDY EXPLORED THE IMPACT OF A BHASTRIKA PRANAYAMA TRAINING PROGRAM ON EMOTION PROCESSING, ANXIETY, AND AFFECT. WE USED A RANDOMIZED CONTROLLED TRIAL DESIGN WITH THIRTY HEALTHY YOUNG ADULTS ASSESSED AT BASELINE AND AFTER 4 WEEKS OF PRANAYAMA PRACTICES. TWO FUNCTIONAL MAGNETIC RESONANCE IMAGING (MRI) PROTOCOLS WERE USED BOTH AT BASELINE AND POST-INTERVENTION: AN EMOTION TASK AS WELL AS A RESTING-STATE ACQUISITION. OUR RESULTS SUGGEST THAT PRANAYAMA SIGNIFICANTLY DECREASED STATES OF ANXIETY AND NEGATIVE AFFECT. THE PRACTICE OF PRANAYAMA ALSO MODULATED THE ACTIVITY OF BRAIN REGIONS INVOLVED IN EMOTIONAL PROCESSING, PARTICULARLY THE AMYGDALA, ANTERIOR CINGULATE, ANTERIOR INSULA, AND PREFRONTAL CORTEX. RESTING-STATE FUNCTIONAL MRI (FMRI) SHOWED SIGNIFICANTLY REDUCED FUNCTIONAL CONNECTIVITY INVOLVING THE ANTERIOR INSULA AND LATERAL PORTIONS OF THE PREFRONTAL CORTEX. CORRELATION ANALYSIS REVEALED THAT CHANGES IN CONNECTIVITY BETWEEN THE VENTROLATERAL PREFRONTAL CORTEX AND THE RIGHT ANTERIOR INSULA WERE ASSOCIATED WITH CHANGES IN ANXIETY. ALTHOUGH IT SHOULD BE NOTED THAT THESE ANALYSES WERE PRELIMINARY AND EXPLORATORY, IT PROVIDES THE FIRST EVIDENCE THAT 4 WEEKS OF B. PRANAYAMA SIGNIFICANTLY REDUCE THE LEVELS OF ANXIETY AND NEGATIVE AFFECT, AND THAT THESE CHANGES ARE ASSOCIATED WITH THE MODULATION OF ACTIVITY AND CONNECTIVITY IN BRAIN AREAS INVOLVED IN EMOTION PROCESSING, ATTENTION, AND AWARENESS. THE STUDY WAS REGISTERED AT HTTPS://WWW.ENSAIOSCLINICOS.GOV.BR/RG/RBR-2GV5C2/(RBR-2GV5C2). 2020 20 1590 20 MEDITATION AND YOGA CAN MODULATE BRAIN MECHANISMS THAT AFFECT BEHAVIOR AND ANXIETY-A MODERN SCIENTIFIC PERSPECTIVE. MEDITATION AND YOGA TECHNIQUES ARE RECEIVING INCREASED ATTENTION THROUGHOUT THE WORLD, DUE TO THE ACCUMULATION OF EVIDENCE BASED RESEARCH THAT PROVES THE DIRECT AND INDIRECT BENEFITS OF SUCH PRACTICES. BASED ON STUDIES CONDUCTED SO FAR, IT HAS BEEN FOUND THAT THE PRACTICE OF MEDITATION TRIGGERS NEUROTRANSMITTERS THAT MODULATE PSYCHOLOGICAL DISORDERS SUCH AS ANXIETY. THIS PAPER WILL REVIEW THE PSYCHOLOGICAL EFFECTS OF THE PRACTICE OF MEDITATION, THE ROLE OF NEUROTRANSMITTERS, AND STUDIES USING EEG AND FMRI. 2015