1 1669 117 NEUROPHYSIOLOGICAL AND NEUROCOGNITIVE MECHANISMS UNDERLYING THE EFFECTS OF YOGA-BASED PRACTICES: TOWARDS A COMPREHENSIVE THEORETICAL FRAMEWORK. DURING RECENT DECADES NUMEROUS YOGA-BASED PRACTICES (YBP) HAVE EMERGED IN THE WEST, WITH THEIR AIMS RANGING FROM FITNESS GAINS TO THERAPEUTIC BENEFITS AND SPIRITUAL DEVELOPMENT. YOGA IS ALSO BEGINNING TO SPARK GROWING INTEREST WITHIN THE SCIENTIFIC COMMUNITY, AND YOGA-BASED INTERVENTIONS HAVE BEEN ASSOCIATED WITH MEASUREABLE CHANGES IN PHYSIOLOGICAL PARAMETERS, PERCEIVED EMOTIONAL STATES, AND COGNITIVE FUNCTIONING. YBP TYPICALLY INVOLVE A COMBINATION OF POSTURES OR MOVEMENT SEQUENCES, CONSCIOUS REGULATION OF THE BREATH, AND VARIOUS TECHNIQUES TO IMPROVE ATTENTIONAL FOCUS. HOWEVER, SO FAR LITTLE IF ANY RESEARCH HAS ATTEMPTED TO DECONSTRUCT THE ROLE OF THESE DIFFERENT COMPONENT PARTS IN ORDER TO BETTER UNDERSTAND THEIR RESPECTIVE CONTRIBUTION TO THE EFFECTS OF YBP. A CLEAR OPERATIONAL DEFINITION OF YOGA-BASED THERAPEUTIC INTERVENTIONS FOR SCIENTIFIC PURPOSES, AS WELL AS A COMPREHENSIVE THEORETICAL FRAMEWORK FROM WHICH TESTABLE HYPOTHESES CAN BE FORMULATED, IS THEREFORE NEEDED. HERE WE PROPOSE SUCH A FRAMEWORK, AND OUTLINE THE BOTTOM-UP NEUROPHYSIOLOGICAL AND TOP-DOWN NEUROCOGNITIVE MECHANISMS HYPOTHESIZED TO BE AT PLAY IN YBP. 2015 2 2086 41 THE EFFECT OF MOVEMENT-FOCUSED AND BREATH-FOCUSED YOGA PRACTICE ON STRESS PARAMETERS AND SUSTAINED ATTENTION: A RANDOMIZED CONTROLLED PILOT STUDY. YOGA-BASED PRACTICES (YBP) TYPICALLY INVOLVE A COMBINATION OF MOVEMENT SEQUENCES, CONSCIOUS REGULATION OF THE BREATH, AND TECHNIQUES TO ENGAGE ATTENTION. HOWEVER, LITTLE IS KNOWN ABOUT WHETHER EFFECTS OF YBP RESULT FROM THE SYNERGISTIC COMBINATION OF THESE COMPONENTS, OR WHETHER A SUBSET MAY YIELD SIMILAR EFFECTS. IN THIS STUDY WE COMPARED THE EFFECT OF A MOVEMENT-FOCUSED PRACTICE AND A BREATH-FOCUSED PRACTICE ON STRESS PARAMETERS (PERCEIVED STRESS AND SALIVARY CORTISOL) AND SUSTAINED ATTENTION (RESPONSE INHIBITION) IN YOGA NAIVE UNIVERSITY STUDENTS. WHILE PARTICIPANTS OF BOTH PROGRAMS SHOWED A REDUCTION IN PERCEIVED STRESS AND SALIVARY CORTISOL, ONLY THE BREATH-FOCUSED GROUP SHOWED IMPROVEMENTS IN SUSTAINED ATTENTION. IN ADDITION, IMPROVEMENT IN SUSTAINED ATTENTION WAS CORRELATED WITH REDUCTION IN PERCEIVED STRESS BUT NOT WITH REDUCTION IN SALIVARY CORTISOL. WE DISCUSS THESE FINDINGS IN THE CONTEXT OF A THEORETICAL FRAMEWORK OUTLINING BOTTOM-UP NEUROPHYSIOLOGICAL AND TOP-DOWN NEUROCOGNITIVE MECHANISMS HYPOTHESIZED TO BE ENGAGED BY YBP. 2018 3 422 34 BRIDGING THE SCHISM OF SCHIZOPHRENIA THROUGH YOGA-REVIEW OF PUTATIVE MECHANISMS. SCHIZOPHRENIA PATIENTS EXPERIENCE A 'DISCONNECT' AT MULTIPLE LEVELS-NEURONAL NETWORKS, MENTAL PROCESSES, AND INTERPERSONAL RELATIONSHIPS. THE RESULTANT POOR QUALITY-OF-LIFE AND FUNCTIONAL DISABILITY ARE RELATED TO THE PERSISTENT COGNITIVE DEFICITS AND NEGATIVE SYMPTOMS, WHICH ARE RATHER RESISTANT TO CONVENTIONAL ANTIPSYCHOTIC MEDICATIONS. YOGA HAS EMERGED AS AN IMPORTANT THERAPEUTIC INTERVENTION TO IMPROVE QUALITY-OF-LIFE IN SCHIZOPHRENIA. RECENT PRELIMINARY EVIDENCE SUGGESTS THAT EFFECTS OF YOGA ON COGNITIVE AND NEGATIVE SYMPTOMS MAY DRIVE THIS BENEFIT. THIS STUDY ATTEMPTS TO INTEGRATE EVIDENCE FROM NEUROSCIENCE-BASED RESEARCH, WHICH FOCUSES ON THE NEUROPLASTICITY-HARNESSING EFFECTS OF YOGA TO BRIDGE THE SCHIZOPHRENIA CONNECTOPATHY. IN AN OVERARCHING MODEL TO STUDY PUTATIVE NEUROBIOLOGICAL MECHANISMS THAT DRIVE THERAPEUTIC EFFECTS OF YOGA, IT IS PROPOSED THAT (A) VARIOUS STYLES OF MEDITATION MAY HELP IN STRENGTHENING THE LATERAL AND MEDIAL PREFRONTAL BRAIN NETWORKS, THUS IMPROVING NEUROCOGNITION AND MENTALIZING ABILITIES, AND (B) LEARNING AND PERFORMING CO-ORDINATED PHYSICAL POSTURES WITH A TEACHER FACILITATES IMITATION AND THE PROCESS OF BEING IMITATED, WHICH CAN IMPROVE SOCIAL COGNITION AND EMPATHY THROUGH REINFORCEMENT OF THE PREMOTOR AND PARIETAL MIRROR NEURON SYSTEM. OXYTOCIN MAY PLAY A ROLE IN MEDIATING THESE PROCESSES, LEADING TO BETTER SOCIAL CONNECTEDNESS AND SOCIAL OUTCOMES. CLINICAL AND HEURISTIC IMPLICATIONS OF THIS MODEL ARE FURTHER DISCUSSED. 2016 4 1822 27 PROTOCOL TO EVALUATE THE IMPACT OF YOGA SUPPLEMENTATION ON COGNITIVE FUNCTION IN SCHIZOPHRENIA: A RANDOMISED CONTROLLED TRIAL. BACKGROUND: SCHIZOPHRENIA (SZ) IS A CHRONIC ILLNESS THAT IS TREATED SYMPTOMATICALLY. COGNITIVE DYSFUNCTION IS A CORE FEATURE OF SZ THAT IS RELATIVELY INTRACTABLE TO PHARMACOTHERAPY. YOGA CAN IMPROVE COGNITIVE FUNCTION AMONG HEALTHY INDIVIDUALS. A RECENT OPEN TRIAL INDICATED SIGNIFICANT BENEFITS OF YOGA TRAINING (YT) IN CONJUNCTION WITH CONVENTIONAL PHARMACOTHERAPY AMONG PATIENTS WITH SZ. AIMS: TO DESCRIBE THE PROTOCOL FOR AN ONGOING RANDOMISED CONTROLLED TRIAL DESIGNED TO TEST WHETHER THE REPORTED BENEFICIAL EFFECTS OF YT ON COGNITIVE FUNCTION AMONG SZ PATIENTS CAN BE REPLICATED. SECONDARILY, THE EFFECTS OF YT ON DAILY FUNCTIONING LIVING SKILLS ARE EVALUATED. METHODS: CONSENTING PATIENTS WITH SZ RECEIVE ROUTINE CLINICAL TREATMENT AND ARE RANDOMISED TO ADJUNCTIVE YT, ADJUNCTIVE PHYSICAL EXERCISE (PE) OR TREATMENT AS USUAL (PROPOSED N = 234 TOTAL, N = 78 IN EACH GROUP). THE TRIAL INVOLVES YT OR PE 5 DAYS A WEEK AND LASTS 3 WEEKS. PARTICIPANTS ARE EVALUATED THRICE OVER 6 MONTHS. COGNITIVE FUNCTIONS MEASURED BY TRAIL MAKING TEST, UNIVERSITY OF PENNSYLVANIA NEUROCOGNITIVE COMPUTERISED BATTERY WERE PRIMARY OUTCOME MEASURES WHILE CLINICAL SEVERITY AND DAILY FUNCTIONING MEASURED BY INDEPENDENT LIVING SKILLS SURVEY WERE SECONDARY OUTCOME MEASURES. RESULTS: A TOTAL OF 309 PARTICIPANTS HAVE BEEN RANDOMISED AS OF 31 AUGUST 2013, WHICH EXCEEDED BEYOND 294 PROPOSED AFTER ATTRITION. ONCE PARTICIPANTS BEGIN YT OR PE THEY GENERALLY COMPLETE THE PROTOCOL. NO INJURIES HAVE BEEN REPORTED. CONCLUSIONS: SHORT TERM YT IS FEASIBLE AND ACCEPTABLE TO INDIAN SZ PATIENTS. IF BENEFICIAL EFFECTS OF YT ARE DETECTED, IT WILL PROVIDE A NOVEL ADJUNCTIVE COGNITIVE REMEDIATION STRATEGY FOR SZ PATIENTS. 2014 5 288 24 ADJUNCTIVE COGNITIVE REMEDIATION FOR SCHIZOPHRENIA USING YOGA: AN OPEN, NON-RANDOMIZED TRIAL. BACKGROUND: YOGA THERAPY (YT) IMPROVES COGNITIVE FUNCTION IN HEALTHY INDIVIDUALS, BUT ITS IMPACT ON COGNITIVE FUNCTION AMONG PERSONS WITH SCHIZOPHRENIA (SZ) HAS NOT BEEN INVESTIGATED. AIMS: EVALUATE ADJUNCTIVE YT FOR COGNITIVE DOMAINS IMPAIRED IN SZ. METHODS: PATIENTS WITH SZ RECEIVED YT OR TREATMENT AS USUAL (TAU; N = 65, N = 23, RESPECTIVELY). ACCURACY AND SPEED FOR SEVEN COGNITIVE DOMAINS WERE ASSESSED USING A COMPUTERIZED NEUROCOGNITIVE BATTERY (CNB), THUS MINIMIZING OBSERVER BIAS. SEPARATELY, YT WAS EVALUATED AMONG PATIENTS WITH BIPOLAR I DISORDER (N = 40), MAJOR DEPRESSIVE DISORDER (N = 37), AND CARDIOLOGY OUTPATIENTS (N = 68). ALL PATIENTS ALSO RECEIVED ROUTINE PHARMACOTHERAPY. PATIENTS WERE NOT RANDOMIZED TO YT OR TAU. RESULTS: COMPARED WITH THE SZ/TAU GROUP, THE SZ/YT GROUP SHOWED SIGNIFICANTLY GREATER IMPROVEMENT WITH REGARD TO MEASURES OF ATTENTION FOLLOWING CORRECTIONS FOR MULTIPLE COMPARISONS; THE CHANGES WERE MORE PROMINENT AMONG THE MEN. IN THE OTHER DIAGNOSTIC GROUPS, DIFFERING PATTERNS OF IMPROVEMENTS WERE NOTED WITH SMALL TO MEDIUM EFFECT SIZES. CONCLUSIONS: OUR INITIAL ANALYSES SUGGEST NOMINALLY SIGNIFICANT IMPROVEMENT IN COGNITIVE FUNCTION IN SCHIZOPHRENIA WITH ADJUNCTIVE THERAPIES SUCH AS YT. THE MAGNITUDE OF THE CHANGE VARIES BY COGNITIVE DOMAIN AND MAY ALSO VARY BY DIAGNOSTIC GROUP. 2012 6 76 26 A HEURISTIC MODEL LINKING YOGA PHILOSOPHY AND SELF-REFLECTION TO EXAMINE UNDERLYING MECHANISMS OF ADD-ON YOGA TREATMENT IN SCHIZOPHRENIA. PRELIMINARY EVIDENCE SUGGESTS EFFICACY OF YOGA AS ADD-ON TREATMENT FOR SCHIZOPHRENIA, BUT THE UNDERLYING MECHANISM BY WHICH YOGA IMPROVES THE SYMPTOMS OF SCHIZOPHRENIA IS NOT COMPLETELY UNDERSTOOD. YOGA IMPROVES SELF-REFLECTION IN HEALTHY INDIVIDUALS, AND SELF-REFLECTION ABNORMALITIES ARE TYPICALLY SEEN IN SCHIZOPHRENIA. HOWEVER, WHETHER YOGA TREATMENT IMPROVES IMPAIRMENTS IN SELF-REFLECTION TYPICALLY SEEN IN PATIENTS WITH SCHIZOPHRENIA IS NOT EXAMINED. THIS PAPER DISCUSSES THE POTENTIAL MECHANISM OF YOGA IN THE TREATMENT OF SCHIZOPHRENIA AND PROPOSES A TESTABLE HYPOTHESIS FOR FURTHER EMPIRICAL STUDIES. IT IS PROPOSED THAT SELF-REFLECTION ABNORMALITIES IN SCHIZOPHRENIA IMPROVE WITH YOGA AND THE NEUROBIOLOGICAL CHANGES ASSOCIATED WITH THIS CAN BE EXAMINED USING EMPIRICAL BEHAVIOURAL MEASURES AND NEUROIMAGING MEASURES SUCH AS MAGNETIC RESONANCE IMAGING. 2016 7 2781 44 YOGA THERAPY AND POLYVAGAL THEORY: THE CONVERGENCE OF TRADITIONAL WISDOM AND CONTEMPORARY NEUROSCIENCE FOR SELF-REGULATION AND RESILIENCE. YOGA THERAPY IS A NEWLY EMERGING, SELF-REGULATING COMPLEMENTARY AND INTEGRATIVE HEALTHCARE (CIH) PRACTICE. IT IS GROWING IN ITS PROFESSIONALIZATION, RECOGNITION AND UTILIZATION WITH A DEMONSTRATED COMMITMENT TO SETTING PRACTICE STANDARDS, EDUCATIONAL AND ACCREDITATION STANDARDS, AND PROMOTING RESEARCH TO SUPPORT ITS EFFICACY FOR VARIOUS POPULATIONS AND CONDITIONS. HOWEVER, HETEROGENEITY OF PRACTICE, POOR REPORTING STANDARDS, AND LACK OF A BROADLY ACCEPTED UNDERSTANDING OF THE NEUROPHYSIOLOGICAL MECHANISMS INVOLVED IN YOGA THERAPY LIMITS THE STRUCTURING OF TESTABLE HYPOTHESES AND CLINICAL APPLICATIONS. CURRENT PROPOSED FRAMEWORKS OF YOGA-BASED PRACTICES FOCUS ON THE INTEGRATION OF BOTTOM-UP NEUROPHYSIOLOGICAL AND TOP-DOWN NEUROCOGNITIVE MECHANISMS. IN ADDITION, IT HAS BEEN PROPOSED THAT PHENOMENOLOGY AND FIRST PERSON ETHICAL INQUIRY CAN PROVIDE A LENS THROUGH WHICH YOGA THERAPY IS VIEWED AS A PROCESS THAT CONTRIBUTES TOWARDS EUDAIMONIC WELL-BEING IN THE EXPERIENCE OF PAIN, ILLNESS OR DISABILITY. IN THIS ARTICLE WE BUILD ON THESE FRAMEWORKS, AND PROPOSE A MODEL OF YOGA THERAPY THAT CONVERGES WITH POLYVAGAL THEORY (PVT). PVT LINKS THE EVOLUTION OF THE AUTONOMIC NERVOUS SYSTEM TO THE EMERGENCE OF PROSOCIAL BEHAVIORS AND POSITS THAT THE NEURAL PLATFORMS SUPPORTING SOCIAL BEHAVIOR ARE INVOLVED IN MAINTAINING HEALTH, GROWTH AND RESTORATION. THIS EXPLANATORY MODEL WHICH CONNECTS NEUROPHYSIOLOGICAL PATTERNS OF AUTONOMIC REGULATION AND EXPRESSION OF EMOTIONAL AND SOCIAL BEHAVIOR, IS INCREASINGLY UTILIZED AS A FRAMEWORK FOR UNDERSTANDING HUMAN BEHAVIOR, STRESS AND ILLNESS. SPECIFICALLY, WE DESCRIBE HOW PVT CAN BE CONCEPTUALIZED AS A NEUROPHYSIOLOGICAL COUNTERPART TO THE YOGIC CONCEPT OF THE GUNAS, OR QUALITIES OF NATURE. SIMILAR TO THE NEURAL PLATFORMS DESCRIBED IN PVT, THE GUNAS PROVIDE THE FOUNDATION FROM WHICH BEHAVIORAL, EMOTIONAL AND PHYSICAL ATTRIBUTES EMERGE. WE DESCRIBE HOW THESE TWO DIFFERENT YET ANALOGOUS FRAMEWORKS-ONE BASED IN NEUROPHYSIOLOGY AND THE OTHER IN AN ANCIENT WISDOM TRADITION-HIGHLIGHT YOGA THERAPY'S PROMOTION OF PHYSICAL, MENTAL AND SOCIAL WELLBEING FOR SELF-REGULATION AND RESILIENCE. THIS PARALLEL BETWEEN THE NEURAL PLATFORMS OF PVT AND THE GUNAS OF YOGA IS INSTRUMENTAL IN CREATING A TRANSLATIONAL FRAMEWORK FOR YOGA THERAPY TO ALIGN WITH ITS PHILOSOPHICAL FOUNDATIONS. CONSEQUENTLY, YOGA THERAPY CAN OPERATE AS A DISTINCT PRACTICE RATHER THAN FITTING INTO AN OUTSIDE MODEL FOR ITS UTILIZATION IN RESEARCH AND CLINICAL CONTEXTS. 2018 8 1668 26 NEUROCOGNITIVE CORRELATES OF THE EFFECTS OF YOGA MEDITATION PRACTICE ON EMOTION AND COGNITION: A PILOT STUDY. MINDFULNESS MEDITATION INVOLVES ATTENDING TO EMOTIONS WITHOUT COGNITIVE FIXATION OF EMOTIONAL EXPERIENCE. OVER TIME, THIS PRACTICE IS HELD TO PROMOTE ALTERATIONS IN TRAIT AFFECTIVITY AND ATTENTIONAL CONTROL WITH RESULTANT EFFECTS ON WELL-BEING AND COGNITION. HOWEVER, RELATIVELY LITTLE IS KNOWN REGARDING THE NEURAL SUBSTRATES OF MEDITATION EFFECTS ON EMOTION AND COGNITION. THE PRESENT STUDY INVESTIGATED THE NEUROCOGNITIVE CORRELATES OF EMOTION INTERFERENCE ON COGNITION IN YOGA PRACTITIONERS AND A MATCHED CONTROL GROUP (CG) UNDERWENT FMRI WHILE PERFORMING AN EVENT-RELATED AFFECTIVE STROOP TASK. THE TASK INCLUDES IMAGE VIEWING TRIALS AND STROOP TRIALS BRACKETED BY NEUTRAL OR NEGATIVE EMOTIONAL DISTRACTORS. DURING IMAGE VIEWING TRIALS, YOGA PRACTITIONERS EXHIBITED LESS REACTIVITY IN RIGHT DORSOLATERAL PREFRONTAL CORTEX (DLPFC) TO NEGATIVE AS COMPARED TO NEUTRAL IMAGES; WHEREAS THE CG HAD THE OPPOSITE PATTERN. A MAIN EFFECT OF VALENCE (NEGATIVE > NEUTRAL) WAS OBSERVED IN LIMBIC REGIONS (E.G., AMYGDALA), OF WHICH THE MAGNITUDE WAS INVERSELY RELATED TO DLPFC ACTIVATION. EXPLORATORY ANALYSES REVEALED THAT THE MAGNITUDE OF AMYGDALA ACTIVATION PREDICTED DECREASED SELF-REPORTED POSITIVE AFFECT IN THE CG, BUT NOT AMONG YOGA PRACTITIONERS. DURING STROOP TRIALS, YOGA PRACTITIONERS HAD GREATER ACTIVATION IN VENTROLATERAL PREFRONTAL CORTEX (VLPFC) DURING STROOP TRIALS WHEN NEGATIVE, COMPARED TO NEUTRAL, EMOTIONAL DISTRACTOR WERE PRESENTED; THE CG EXHIBITED THE OPPOSITE PATTERN. TAKEN TOGETHER, THESE DATA SUGGEST THAT THOUGH YOGA PRACTITIONERS EXHIBIT LIMBIC REACTIVITY TO NEGATIVE EMOTIONAL STIMULI, SUCH REACTIVITY DOES NOT HAVE DOWNSTREAM EFFECTS ON LATER MOOD STATE. THIS UNCOUPLING OF VIEWING NEGATIVE EMOTIONAL IMAGES AND AFFECT AMONG YOGA PRACTITIONERS MAY BE OCCASIONED BY THEIR SELECTIVE IMPLEMENTATION OF FRONTAL EXECUTIVE-DEPENDENT STRATEGIES TO REDUCE EMOTIONAL INTERFERENCE DURING COMPETING COGNITIVE DEMANDS AND NOT DURING EMOTIONAL PROCESSING PER SE. 2012 9 161 22 A RANDOMISED CONTROLLED TRIAL OF ADJUNCTIVE YOGA AND ADJUNCTIVE PHYSICAL EXERCISE TRAINING FOR COGNITIVE DYSFUNCTION IN SCHIZOPHRENIA. BACKGROUND: YOGA AND PHYSICAL EXERCISE HAVE BEEN USED AS ADJUNCTIVE INTERVENTION FOR COGNITIVE DYSFUNCTION IN SCHIZOPHRENIA (SZ), BUT CONTROLLED COMPARISONS ARE LACKING. AIMS A SINGLE-BLIND RANDOMISED CONTROLLED TRIAL WAS DESIGNED TO EVALUATE WHETHER YOGA TRAINING OR PHYSICAL EXERCISE TRAINING ENHANCE COGNITIVE FUNCTIONS IN SZ, BASED ON A PRIOR PILOT STUDY. METHODS: CONSENTING, CLINICALLY STABLE, ADULT OUTPATIENTS WITH SZ (N=286) COMPLETED BASELINE ASSESSMENTS AND WERE RANDOMISED TO TREATMENT AS USUAL (TAU), SUPERVISED YOGA TRAINING WITH TAU (YT) OR SUPERVISED PHYSICAL EXERCISE TRAINING WITH TAU (PE). BASED ON THE PILOT STUDY, THE PRIMARY OUTCOME MEASURE WAS SPEED INDEX FOR THE COGNITIVE DOMAIN OF 'ATTENTION' IN THE PENN COMPUTERISED NEUROCOGNITIVE BATTERY. USING MIXED MODELS AND CONTRASTS, COGNITIVE FUNCTIONS AT BASELINE, 21 DAYS (END OF TRAINING), 3 AND 6 MONTHS POST-TRAINING WERE EVALUATED WITH INTENTION-TO-TREAT PARADIGM. RESULTS: SPEED INDEX OF ATTENTION DOMAIN IN THE YT GROUP SHOWED GREATER IMPROVEMENT THAN PE AT 6 MONTHS FOLLOW-UP (P<0.036, EFFECT SIZE 0.51). IN THE PE GROUP, 'ACCURACY INDEX OF ATTENTION DOMAIN SHOWED GREATER IMPROVEMENT THAN TAU ALONE AT 6-MONTH FOLLOW-UP (P<0.025, EFFECT SIZE 0.61). FOR SEVERAL OTHER COGNITIVE DOMAINS, SIGNIFICANT IMPROVEMENTS WERE OBSERVED WITH YT OR PE COMPARED WITH TAU ALONE (P<0.05, EFFECT SIZES 0.30-1.97). CONCLUSIONS: BOTH YT AND PE IMPROVED ATTENTION AND ADDITIONAL COGNITIVE DOMAINS WELL PAST THE TRAINING PERIOD, SUPPORTING OUR PRIOR REPORTED BENEFICIAL EFFECT OF YT ON SPEED INDEX OF ATTENTION DOMAIN. AS ADJUNCTS, YT OR PE CAN BENEFIT INDIVIDUALS WITH SZ. 2017 10 875 21 EFFECT OF YOGA THERAPY ON PLASMA OXYTOCIN AND FACIAL EMOTION RECOGNITION DEFICITS IN PATIENTS OF SCHIZOPHRENIA. CONTEXT: YOGA THERAPY HAS BEEN DEMONSTRATED TO BE USEFUL IN TREATMENT OF NEGATIVE SYMPTOMS AND IMPROVING THE SOCIO-OCCUPATIONAL FUNCTIONING AND EMOTION RECOGNITION DEFICITS IN ANTIPSYCHOTIC-STABILIZED SCHIZOPHRENIA PATIENTS. OXYTOCIN HAS BEEN RECENTLY IMPLICATED IN SOCIAL COGNITION DEFICITS IN SCHIZOPHRENIA. THE EFFECT OF YOGA THERAPY ON OXYTOCIN LEVELS IN SCHIZOPHRENIA HAS NOT BEEN STUDIED. AIMS: THIS STUDY AIMED TO ASSESS THE EFFECT OF YOGA THERAPY ON SYMPTOMS, SOCIO-OCCUPATIONAL FUNCTIONING, FACIAL EMOTION RECOGNITION DEFICITS AND PLASMA OXYTOCIN LEVELS IN ANTIPSYCHOTIC STABILIZED SCHIZOPHRENIA PATIENTS. SETTINGS AND DESIGN: RANDOMIZED CONTROLLED STUDY ON 43 CONSENTING, MEDICATION STABILIZED PATIENTS WITH SCHIZOPHRENIA IN A TERTIARY PSYCHIATRIC CENTER USING YOGA INTERVENTION AND WAITLISTED GROUPS. MATERIALS AND METHODS: A TOTAL OF 43 SCHIZOPHRENIA PATIENTS WERE RANDOMIZED TO YOGA GROUP (N=15) OR WAITLIST GROUP (N=28). PATIENTS IN THE YOGA GROUP RECEIVED TRAINING IN A SPECIFIC YOGA THERAPY MODULE FOR SCHIZOPHRENIA. PATIENTS IN BOTH GROUPS WERE CONTINUED ON STABLE ANTIPSYCHOTIC MEDICATION. ASSESSMENTS INCLUDED SCALE FOR ASSESSMENT OF POSITIVE SYMPTOMS, SCALE FOR ASSESSMENT OF NEGATIVE SYMPTOMS, SOCIO-OCCUPATIONAL FUNCTIONING SCALE AND TOOL FOR RECOGNITION OF EMOTIONS IN NEUROPSYCHIATRIC DISORDERS (TRENDS) AND PLASMA OXYTOCIN LEVELS; PERFORMED AT BASELINE AND AT THE END OF 1 MONTH. RESULTS: A TOTAL OF 15 PATIENTS IN THE YOGA GROUP AND 12 IN WAITLIST GROUP COMPLETED THE STUDY. THE YOGA THERAPY GROUP SHOWED A SIGNIFICANT IMPROVEMENT IN SOCIO-OCCUPATIONAL FUNCTIONING, PERFORMANCE ON TRENDS (P<0.001) AND PLASMA INCREASE IN OXYTOCIN LEVELS (P=0.01) AS COMPARED WITH THE WAITLIST GROUP. CONCLUSION: THE STUDY SUPPORTED THE ROLE OF ADD-ON YOGA THERAPY IN MANAGEMENT OF SCHIZOPHRENIA AND DEMONSTRATED AN IMPROVEMENT IN ENDOGENOUS PLASMA OXYTOCIN LEVELS IN SCHIZOPHRENIA PATIENTS RECEIVING YOGA THERAPY. 2013 11 872 25 EFFECT OF YOGA THERAPY ON FACIAL EMOTION RECOGNITION DEFICITS, SYMPTOMS AND FUNCTIONING IN PATIENTS WITH SCHIZOPHRENIA. OBJECTIVE: FACIAL EMOTION RECOGNITION DEFICITS HAVE BEEN CONSISTENTLY DEMONSTRATED IN SCHIZOPHRENIA AND CAN IMPAIR SOCIO-OCCUPATIONAL FUNCTIONING IN THESE PATIENTS. TREATMENTS TO IMPROVE THESE DEFICITS IN ANTIPSYCHOTIC-STABILIZED PATIENTS HAVE NOT BEEN WELL STUDIED. YOGA THERAPY HAS BEEN DESCRIBED TO IMPROVE FUNCTIONING IN VARIOUS DOMAINS IN SCHIZOPHRENIA; HOWEVER, ITS EFFECT ON FERD IS NOT KNOWN. METHOD: ANTIPSYCHOTIC-STABILIZED PATIENTS RANDOMIZED TO RECEIVE YOGA (N=27), EXERCISE (N=17) OR WAITLIST GROUP (N=22) WERE ASSESSED AT BASELINE, 2ND MONTH, AND 4TH MONTH OF FOLLOW-UP BY RATERS BLIND TO GROUP STATUS. ASSESSMENTS INCLUDED POSITIVE AND NEGATIVE SYNDROME SCALE (PANSS), SOCIO-OCCUPATIONAL FUNCTIONING SCALE (SOFS), AND TOOL FOR RECOGNITION OF EMOTIONS IN NEUROPSYCHIATRIC DISORDERS (TRENDS). RESULTS: THERE WAS A SIGNIFICANT POSITIVE CORRELATION BETWEEN BASELINE FERD AND SOCIO-OCCUPATIONAL FUNCTIONING (R=0.3, P=0.01). PAIRED SAMPLES T TEST SHOWED SIGNIFICANT IMPROVEMENT IN POSITIVE AND NEGATIVE SYMPTOMS, SOCIO-OCCUPATIONAL FUNCTIONING AND PERFORMANCE ON TRENDS (P<0.05) IN THE YOGA GROUP, BUT NOT IN THE OTHER TWO GROUPS. MAXIMUM IMPROVEMENT OCCURRED AT THE END OF 2 MONTHS, AND IMPROVEMENT IN POSITIVE AND NEGATIVE SYMPTOMS PERSISTED AT THE END OF 4 MONTHS. CONCLUSION: YOGA THERAPY CAN BE A USEFUL ADD-ON TREATMENT TO IMPROVE PSYCHOPATHOLOGY, FERD, AND SOCIO-OCCUPATIONAL FUNCTIONING IN ANTIPSYCHOTIC-STABILIZED PATIENTS WITH SCHIZOPHRENIA. 2011 12 1772 33 POTENTIAL SELF-REGULATORY MECHANISMS OF YOGA FOR PSYCHOLOGICAL HEALTH. RESEARCH SUGGESTING THE BENEFICIAL EFFECTS OF YOGA ON MYRIAD ASPECTS OF PSYCHOLOGICAL HEALTH HAS PROLIFERATED IN RECENT YEARS, YET THERE IS CURRENTLY NO OVERARCHING FRAMEWORK BY WHICH TO UNDERSTAND YOGA'S POTENTIAL BENEFICIAL EFFECTS. HERE WE PROVIDE A THEORETICAL FRAMEWORK AND SYSTEMS-BASED NETWORK MODEL OF YOGA THAT FOCUSES ON INTEGRATION OF TOP-DOWN AND BOTTOM-UP FORMS OF SELF-REGULATION. WE BEGIN BY CONTEXTUALIZING YOGA IN HISTORICAL AND CONTEMPORARY SETTINGS, AND THEN DETAIL HOW SPECIFIC COMPONENTS OF YOGA PRACTICE MAY AFFECT COGNITIVE, EMOTIONAL, BEHAVIORAL, AND AUTONOMIC OUTPUT UNDER STRESS THROUGH AN EMPHASIS ON INTEROCEPTION AND BOTTOM-UP INPUT, RESULTING IN PHYSICAL AND PSYCHOLOGICAL HEALTH. THE MODEL DESCRIBES YOGA PRACTICE AS A COMPREHENSIVE SKILLSET OF SYNERGISTIC PROCESS TOOLS THAT FACILITATE BIDIRECTIONAL FEEDBACK AND INTEGRATION BETWEEN HIGH- AND LOW-LEVEL BRAIN NETWORKS, AND AFFERENT AND RE-AFFERENT INPUT FROM INTEROCEPTIVE PROCESSES (SOMATOSENSORY, VISCEROSENSORY, CHEMOSENSORY). FROM A PREDICTIVE CODING PERSPECTIVE WE PROPOSE A SHIFT TO PERCEPTUAL INFERENCE FOR STRESS MODULATION AND OPTIMAL SELF-REGULATION. WE DESCRIBE HOW THE PROCESSES THAT SUB-SERVE SELF-REGULATION BECOME MORE AUTOMATIZED AND EFFICIENT OVER TIME AND PRACTICE, REQUIRING LESS EFFORT TO INITIATE WHEN NECESSARY AND TERMINATE MORE RAPIDLY WHEN NO LONGER NEEDED. TO SUPPORT OUR PROPOSED MODEL, WE PRESENT THE AVAILABLE EVIDENCE FOR YOGA AFFECTING SELF-REGULATORY PATHWAYS, INTEGRATING EXISTING CONSTRUCTS FROM BEHAVIOR THEORY AND COGNITIVE NEUROSCIENCE WITH EMERGING YOGA AND MEDITATION RESEARCH. THIS PAPER IS INTENDED TO GUIDE FUTURE BASIC AND CLINICAL RESEARCH, SPECIFICALLY TARGETING AREAS OF DEVELOPMENT IN THE TREATMENT OF STRESS-MEDIATED PSYCHOLOGICAL DISORDERS. 2014 13 2776 33 YOGA SCHOOL OF THOUGHT AND PSYCHIATRY: THERAPEUTIC POTENTIAL. YOGA IS A TRADITIONAL LIFE-STYLE PRACTICE USED FOR SPIRITUAL REASONS. HOWEVER, THE PHYSICAL COMPONENTS LIKE THE ASANAS AND PRANAYAAMAS HAVE DEMONSTRATED PHYSIOLOGICAL AND THERAPEUTIC EFFECTS. THERE IS EVIDENCE FOR YOGA AS BEING A POTENT ANTIDEPRESSANT THAT MATCHES WITH DRUGS. IN DEPRESSIVE DISORDER, YOGA 'CORRECTS' AN UNDERLYING COGNITIVE PHYSIOLOGY. IN SCHIZOPHRENIA PATIENTS, YOGA HAS BENEFITS AS AN ADD-ON INTERVENTION IN PHARMACOLOGICALLY STABILIZED SUBJECTS. THE EFFECTS ARE PARTICULARLY NOTABLE ON NEGATIVE SYMPTOMS. YOGA ALSO HELPS TO CORRECT SOCIAL COGNITION. YOGA CAN BE INTRODUCED EARLY IN THE TREATMENT OF PSYCHOSIS WITH SOME BENEFITS. ELEVATION OF OXYTOCIN MAY BE A MECHANISM OF YOGA EFFECTS IN SCHIZOPHRENIA. CERTAIN COMPONENTS OF YOGA HAVE DEMONSTRATED NEUROBIOLOGICAL EFFECTS SIMILAR TO THOSE OF VAGAL STIMULATION, INDICATING THIS (INDIRECT OR AUTOGENOUS VAGAL STIMULATION) AS A POSSIBLE MECHANISM OF ITS ACTION. IT IS TIME, PSYCHIATRISTS EXPLOITED THE BENEFITS IF YOGA FOR A COMPREHENSIVE CARE IN THEIR PATIENTS. 2013 14 2886 33 YOGA: BALANCING THE EXCITATION-INHIBITION EQUILIBRIUM IN PSYCHIATRIC DISORDERS. SOCIAL BEHAVIORAL DISTURBANCES ARE CENTRAL TO MOST PSYCHIATRIC DISORDERS. A DISEQUILIBRIUM WITHIN THE CORTICAL EXCITATORY AND INHIBITORY NEUROTRANSMITTER SYSTEMS UNDERLIES THESE DEFICITS. GAMMA-AMINOBUTYRIC ACID (GABA) AND GLUTAMATE ARE THE MOST ABUNDANT EXCITATORY AND INHIBITORY NEUROTRANSMITTERS IN THE BRAIN THAT CONTRIBUTE TO THIS EQUILIBRIUM. SEVERAL CONTEMPORARY THERAPIES USED IN TREATING PSYCHIATRIC DISORDERS, REGULATE THIS GABA-GLUTAMATE BALANCE. YOGA HAS BEEN STUDIED AS AN ADJUVANT TREATMENT ACROSS A BROAD RANGE OF PSYCHIATRIC DISORDERS AND IS SHOWN TO HAVE SHORT-TERM THERAPEUTIC GAINS. EMERGING EVIDENCE FROM RECENT CLINICAL IN VIVO EXPERIMENTS SUGGESTS THAT YOGA IMPROVES GABA-MEDIATED CORTICAL-INHIBITORY TONE AND ENHANCES PERIPHERAL OXYTOCIN LEVELS. THIS IS LIKELY TO HAVE A MORE CONTROLLED DOWNSTREAM RESPONSE OF THE HYPOTHALAMO-PITUITARY-ADRENAL SYSTEM BY MEANS OF REDUCED CORTISOL RELEASE AND HENCE A BLUNTED SYMPATHETIC RESPONSE TO STRESS. ANIMAL AND EARLY FETAL DEVELOPMENTAL STUDIES SUGGEST AN INTER-DEPENDENT ROLE OF OXYTOCIN AND GABA IN REGULATING SOCIAL BEHAVIORS. IN KEEPING WITH THESE OBSERVATIONS, WE PROPOSE AN INTEGRATED NEUROBIOLOGICAL MODEL TO STUDY THE MECHANISMS OF THERAPEUTIC BENEFITS WITH YOGA. APART FROM PROVIDING A NEUROSCIENTIFIC BASIS FOR APPLYING A TRADITIONAL SYSTEM OF PRACTICE IN THE CLINICAL SETTING, THIS MODEL CAN BE USED AS A FRAMEWORK FOR STUDYING YOGA MECHANISMS IN FUTURE CLINICAL TRIALS. 2019 15 455 22 CHANGES IN NEURAL CONNECTIVITY AND MEMORY FOLLOWING A YOGA INTERVENTION FOR OLDER ADULTS: A PILOT STUDY. BACKGROUND: NO STUDY HAS EXPLORED THE EFFECT OF YOGA ON COGNITIVE DECLINE AND RESTING-STATE FUNCTIONAL CONNECTIVITY. OBJECTIVES: THIS STUDY EXPLORED THE RELATIONSHIP BETWEEN PERFORMANCE ON MEMORY TESTS AND RESTING-STATE FUNCTIONAL CONNECTIVITY BEFORE AND AFTER A YOGA INTERVENTION VERSUS ACTIVE CONTROL FOR SUBJECTS WITH MILD COGNITIVE IMPAIRMENT (MCI). METHODS: PARTICIPANTS ( >/= 55 Y) WITH MCI WERE RANDOMIZED TO RECEIVE A YOGA INTERVENTION OR ACTIVE "GOLD-STANDARD" CONTROL (I.E., MEMORY ENHANCEMENT TRAINING (MET)) FOR 12 WEEKS. RESTING-STATE FUNCTIONAL MAGNETIC RESONANCE IMAGING WAS USED TO MAP CORRELATIONS BETWEEN BRAIN NETWORKS AND MEMORY PERFORMANCE CHANGES OVER TIME. DEFAULT MODE NETWORKS (DMN), LANGUAGE AND SUPERIOR PARIETAL NETWORKS WERE CHOSEN AS NETWORKS OF INTEREST TO ANALYZE THE ASSOCIATION WITH CHANGES IN VERBAL AND VISUOSPATIAL MEMORY PERFORMANCE. RESULTS: FOURTEEN YOGA AND 11 MET PARTICIPANTS COMPLETED THE STUDY. THE YOGA GROUP DEMONSTRATED A STATISTICALLY SIGNIFICANT IMPROVEMENT IN DEPRESSION AND VISUOSPATIAL MEMORY. WE OBSERVED IMPROVED VERBAL MEMORY PERFORMANCE CORRELATED WITH INCREASED CONNECTIVITY BETWEEN THE DMN AND FRONTAL MEDIAL CORTEX, PREGENUAL ANTERIOR CINGULATE CORTEX, RIGHT MIDDLE FRONTAL CORTEX, POSTERIOR CINGULATE CORTEX, AND LEFT LATERAL OCCIPITAL CORTEX. IMPROVED VERBAL MEMORY PERFORMANCE POSITIVELY CORRELATED WITH INCREASED CONNECTIVITY BETWEEN THE LANGUAGE PROCESSING NETWORK AND THE LEFT INFERIOR FRONTAL GYRUS. IMPROVED VISUOSPATIAL MEMORY PERFORMANCE CORRELATED INVERSELY WITH CONNECTIVITY BETWEEN THE SUPERIOR PARIETAL NETWORK AND THE MEDIAL PARIETAL CORTEX. CONCLUSION: YOGA MAY BE AS EFFECTIVE AS MET IN IMPROVING FUNCTIONAL CONNECTIVITY IN RELATION TO VERBAL MEMORY PERFORMANCE. THESE FINDINGS SHOULD BE CONFIRMED IN LARGER PROSPECTIVE STUDIES. 2016 16 644 26 DOES YOGA HAVE A ROLE IN SCHIZOPHRENIA MANAGEMENT? PURPOSE OF REVIEW: TO REVIEW THE EFFICACY OF ADD-ON YOGA THERAPY IN IMPROVING SYMPTOMS OF SCHIZOPHRENIA AND QUALITY OF LIFE AND EXAMINE THE POSSIBLE UNDERLYING BIOLOGICAL MECHANISMS OF YOGA IN SCHIZOPHRENIA. RECENT FINDINGS: QUALITY OF LIFE, COGNITIVE SYMPTOMS, AND NEGATIVE SYMPTOMS HAVE BEEN FOUND TO IMPROVE WITH ADD-ON YOGA THERAPY IN SCHIZOPHRENIA (POOLED MEAN EFFECT SIZE 0.8, 0.6, AND 0.4, RESPECTIVELY). YOGA ALSO SEEMS TO HAVE A SMALL EFFECT ON IMPROVING POSITIVE SYMPTOMS. LESS EXPLORED AREAS INCLUDE ADVERSE EFFECTS OF YOGA ITSELF AS WELL AS ITS EFFECTS ON ANTIPSYCHOTIC-INDUCED COMPLICATIONS. PRELIMINARY FINDINGS SUGGEST THAT THE EFFECTS OF YOGA MAY BE MEDIATED BY NEUROHORMONAL MECHANISMS AND FUNCTIONAL CHANGES IN BRAIN ACTIVITY. ADD-ON YOGA THERAPY IS A POTENTIAL TREATMENT OPTION FOR IMPROVING QUALITY OF LIFE, COGNITIVE SYMPTOMS, AND NEGATIVE SYMPTOMS IN SCHIZOPHRENIA. FUTURE STUDIES SHOULD EXPLORE EFFICACY IN MULTICENTRIC TRIALS AS WELL AS POSSIBLE NEUROBIOLOGICAL CHANGES UNDERLYING THE EFFECTS. 2020 17 1423 21 IMPROVEMENT IN NEUROCOGNITIVE FUNCTIONS AND SERUM BRAIN-DERIVED NEUROTROPHIC FACTOR LEVELS IN PATIENTS WITH DEPRESSION TREATED WITH ANTIDEPRESSANTS AND YOGA. CONTEXT AND AIMS: IMPAIRMENT IN COGNITION IS WELL-KNOWN IN PATIENTS WITH MAJOR DEPRESSIVE DISORDER. THIS STUDY EXAMINED THE EFFECT OF YOGA THERAPY WITH OR WITHOUT ANTIDEPRESSANTS AND ANTIDEPRESSANTS ALONE ON CERTAIN NEUROPSYCHOLOGICAL FUNCTIONS IN PATIENTS WITH DEPRESSION. CORRELATION BETWEEN CHANGES IN NEUROPSYCHOLOGICAL TEST PERFORMANCE AND SERUM BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) LEVELS WAS ALSO EXPLORED. MATERIALS AND METHODS: ANTIDEPRESSANT-NAIVE/ANTIDEPRESSANT-FREE OUTPATIENTS WITH DEPRESSION RECEIVED ANTIDEPRESSANT MEDICATION ALONE (N = 23) OR YOGA THERAPY WITH (N = 26) OR WITHOUT (N = 16) ANTIDEPRESSANTS. DEPRESSION WAS ASSESSED USING THE HAMILTON DEPRESSION RATING SCALE. NEUROPSYCHOLOGICAL TESTS INCLUDED DIGIT-SPAN FORWARD AND BACKWARD, REY AUDITORY VERBAL LEARNING TEST, AND TRAIL MAKING TESTS (TMT-A AND B). THESE TESTS WERE ADMINISTERED BEFORE AND 3 MONTHS AFTER THE TREATMENT IN PATIENTS, AND ONCE IN HEALTHY COMPARISON SUBJECTS (N = 19). STATISTICAL ANALYSIS: BASELINE DIFFERENCES WERE ANALYZED USING INDEPENDENT SAMPLE T-TEST, CHI-SQUARE, AND ONE-WAY ANOVA. PAIRED T-TEST WAS USED TO ANALYZE THE CHANGE FROM BASELINE TO FOLLOW-UP. PEARSON'S CORRELATION WAS USED TO EXPLORE THE ASSOCIATION OF CHANGE BETWEEN 2 VARIABLES. RESULTS: PATIENTS HAD IMPAIRED PERFORMANCE ON MOST NEUROPSYCHOLOGICAL TESTS. AFTER 3 MONTHS, THERE WAS SIGNIFICANT IMPROVEMENT - PATIENTS' PERFORMANCE WAS COMPARABLE TO THAT OF HEALTHY CONTROLS ON MAJORITY OF THE TESTS. SIGNIFICANT INVERSE CORRELATION WAS OBSERVED BETWEEN INCREASE IN BDNF LEVELS AND IMPROVEMENT IN TMT "A" DURATION IN YOGA-ALONE GROUP (R = -0.647; P = 0.009). CONCLUSIONS: TO CONCLUDE THAT, YOGA THERAPY, ALONE OR IN COMBINATION WITH MEDICATIONS, IS ASSOCIATED WITH IMPROVED NEUROPSYCHOLOGICAL FUNCTIONS AND NEUROPLASTIC EFFECTS IN PATIENTS WITH DEPRESSION. 2018 18 2436 32 YOGA AND PSYCHIATRIC DISORDERS: A REVIEW OF BIOMARKER EVIDENCE. TRADITIONALLY, YOGA HAS BEEN USED AS A MEANS FOR SPIRITUAL GROWTH BUT OVER THE PAST TWO DECADES OR SO ITS THERAPEUTIC BENEFITS IN PSYCHIATRIC DISORDERS HAVE BEEN SCIENTIFICALLY EXPLORED. YOGA HAS BEEN SHOWN TO BE USEFUL AS A MONO-THERAPY IN MILD TO MODERATE DEPRESSION AND AS AN ADJUVANT IN SEVERAL PSYCHIATRIC DISORDERS INCLUDING SCHIZOPHRENIA, ANXIETY DISORDERS, SUBSTANCE USE DISORDERS AND MILD COGNITIVE IMPAIRMENT. FURTHERMORE, SYSTEMATIC ATTEMPTS HAVE BEEN MADE TO UNDERSTAND THE BIOLOGICAL CORRELATES OF YOGA IN THESE PSYCHIATRIC DISORDERS. GIVEN THAT NO PSYCHIATRIC DISORDER HAS STRONG AND ESTABLISHED BIOMARKERS, IT IS INTERESTING THAT PRELIMINARY RESEARCH HAS DEMONSTRATED SIGNIFICANT CHANGES IN CERTAIN IMPORTANT BIOMARKERS FOLLOWING REGULAR YOGA PRACTICE. IN THIS BRIEF REVIEW, WE PROVIDE AN UPDATE ON THE EFFECTS OF YOGA ON BIOCHEMICAL, NEURO-PHYSIOLOGICAL AND NEURO-IMAGING RELATED BIO-MARKERS IN PSYCHIATRIC DISORDERS. ALTHOUGH FINDINGS AND TRENDS ARE PROMISING, MUCH MORE RESEARCH IS WARRANTED TO ESTABLISH A DEFINITE BIOLOGICAL BASIS FOR YOGA IN PSYCHIATRY. 2021 19 289 22 ADJUNCTIVE YOGA TRAINING FOR PERSONS WITH SCHIZOPHRENIA: WHO BENEFITS? OBJECTIVE: THE AIM OF THIS STUDY WAS TO IDENTIFY FACTORS ASSOCIATED WITH ACCEPTABILITY AND EFFICACY OF YOGA TRAINING (YT) FOR IMPROVING COGNITIVE DYSFUNCTION IN INDIVIDUALS WITH SCHIZOPHRENIA (SZ). METHODS: WE ANALYSED DATA FROM TWO PUBLISHED CLINICAL TRIALS OF YT FOR COGNITIVE DYSFUNCTION AMONG INDIANS WITH SZ: (1) A 21-DAY RANDOMISED CONTROLLED TRIAL (RCT, N = 286), 3 AND 6 MONTHS FOLLOW-UP AND (2) A 21-DAY OPEN TRIAL (N = 62). MULTIVARIATE ANALYSES WERE CONDUCTED TO EXAMINE THE ASSOCIATION OF BASELINE CHARACTERISTICS (AGE, SEX, SOCIO-ECONOMIC STATUS, EDUCATIONAL STATUS, DURATION, AND SEVERITY OF ILLNESS) WITH IMPROVEMENT IN COGNITION (I.E. ATTENTION AND FACE MEMORY) FOLLOWING YT. FACTORS ASSOCIATED WITH ACCEPTABILITY WERE IDENTIFIED BY COMPARING BASELINE DEMOGRAPHIC VARIABLES BETWEEN SCREENED AND ENROLLED PARTICIPANTS AS WELL AS COMPLETERS VERSUS NON-COMPLETERS. RESULTS: ENROLLED PARTICIPANTS WERE YOUNGER THAN SCREENED PERSONS WHO DECLINED PARTICIPATION (T = 2.952, P = 0.003). NO OTHER CHARACTERISTICS WERE ASSOCIATED WITH STUDY ENROLLMENT OR COMPLETION. REGARDING EFFICACY, SCHOOLING DURATION WAS NOMINALLY ASSOCIATED WITH GREATER AND SUSTAINED COGNITIVE IMPROVEMENT ON A MEASURE OF FACIAL MEMORY. NO OTHER BASELINE CHARACTERISTICS WERE ASSOCIATED WITH EFFICACY OF YT IN THE OPEN TRIAL, THE RCT, OR THE COMBINED SAMPLES (N = 148). CONCLUSIONS: YT IS ACCEPTABLE EVEN AMONG YOUNGER INDIVIDUALS WITH SZ. IT ALSO ENHANCES SPECIFIC COGNITIVE FUNCTIONS, REGARDLESS OF INDIVIDUAL DIFFERENCES IN SELECTED PSYCHOSOCIAL CHARACTERISTICS. THUS, YOGA COULD BE INCORPORATED AS ADJUNCTIVE THERAPY FOR PATIENTS WITH SZ. IMPORTANTLY, OUR RESULTS SUGGEST COGNITIVE DYSFUNCTION IS REMEDIABLE IN PERSONS WITH SZ ACROSS THE AGE SPECTRUM. 2021 20 2608 20 YOGA FOR PSYCHIATRIC DISORDERS: FROM FAD TO EVIDENCE-BASED INTERVENTION? THERE IS GROWING EVIDENCE FOR YOGA'S NEUROBIOLOGICAL EFFECTS IN PEOPLE WITH PSYCHIATRIC DISORDERS. POSTULATED MECHANISMS OF ACTION INCLUDE: (A) MODULATION OF THE HYPOTHALAMIC-PITUITARY-ADRENAL (HPA) AXIS; (B) ENHANCEMENT OF GABAERGIC NEUROTRANSMISSION; (C) AUTONOMIC MODULATION; AND (D) NEUROENDOCRINOLOGICAL EFFECTS. YOGA AS A THERAPEUTIC INTERVENTION IN PSYCHIATRIC DISORDERS APPEARS PROMISING AND MERITS FURTHER ATTENTION IN CLINICAL PRACTICE AND RESEARCH. 2020