1 1669 117 NEUROPHYSIOLOGICAL AND NEUROCOGNITIVE MECHANISMS UNDERLYING THE EFFECTS OF YOGA-BASED PRACTICES: TOWARDS A COMPREHENSIVE THEORETICAL FRAMEWORK. DURING RECENT DECADES NUMEROUS YOGA-BASED PRACTICES (YBP) HAVE EMERGED IN THE WEST, WITH THEIR AIMS RANGING FROM FITNESS GAINS TO THERAPEUTIC BENEFITS AND SPIRITUAL DEVELOPMENT. YOGA IS ALSO BEGINNING TO SPARK GROWING INTEREST WITHIN THE SCIENTIFIC COMMUNITY, AND YOGA-BASED INTERVENTIONS HAVE BEEN ASSOCIATED WITH MEASUREABLE CHANGES IN PHYSIOLOGICAL PARAMETERS, PERCEIVED EMOTIONAL STATES, AND COGNITIVE FUNCTIONING. YBP TYPICALLY INVOLVE A COMBINATION OF POSTURES OR MOVEMENT SEQUENCES, CONSCIOUS REGULATION OF THE BREATH, AND VARIOUS TECHNIQUES TO IMPROVE ATTENTIONAL FOCUS. HOWEVER, SO FAR LITTLE IF ANY RESEARCH HAS ATTEMPTED TO DECONSTRUCT THE ROLE OF THESE DIFFERENT COMPONENT PARTS IN ORDER TO BETTER UNDERSTAND THEIR RESPECTIVE CONTRIBUTION TO THE EFFECTS OF YBP. A CLEAR OPERATIONAL DEFINITION OF YOGA-BASED THERAPEUTIC INTERVENTIONS FOR SCIENTIFIC PURPOSES, AS WELL AS A COMPREHENSIVE THEORETICAL FRAMEWORK FROM WHICH TESTABLE HYPOTHESES CAN BE FORMULATED, IS THEREFORE NEEDED. HERE WE PROPOSE SUCH A FRAMEWORK, AND OUTLINE THE BOTTOM-UP NEUROPHYSIOLOGICAL AND TOP-DOWN NEUROCOGNITIVE MECHANISMS HYPOTHESIZED TO BE AT PLAY IN YBP. 2015 2 1772 33 POTENTIAL SELF-REGULATORY MECHANISMS OF YOGA FOR PSYCHOLOGICAL HEALTH. RESEARCH SUGGESTING THE BENEFICIAL EFFECTS OF YOGA ON MYRIAD ASPECTS OF PSYCHOLOGICAL HEALTH HAS PROLIFERATED IN RECENT YEARS, YET THERE IS CURRENTLY NO OVERARCHING FRAMEWORK BY WHICH TO UNDERSTAND YOGA'S POTENTIAL BENEFICIAL EFFECTS. HERE WE PROVIDE A THEORETICAL FRAMEWORK AND SYSTEMS-BASED NETWORK MODEL OF YOGA THAT FOCUSES ON INTEGRATION OF TOP-DOWN AND BOTTOM-UP FORMS OF SELF-REGULATION. WE BEGIN BY CONTEXTUALIZING YOGA IN HISTORICAL AND CONTEMPORARY SETTINGS, AND THEN DETAIL HOW SPECIFIC COMPONENTS OF YOGA PRACTICE MAY AFFECT COGNITIVE, EMOTIONAL, BEHAVIORAL, AND AUTONOMIC OUTPUT UNDER STRESS THROUGH AN EMPHASIS ON INTEROCEPTION AND BOTTOM-UP INPUT, RESULTING IN PHYSICAL AND PSYCHOLOGICAL HEALTH. THE MODEL DESCRIBES YOGA PRACTICE AS A COMPREHENSIVE SKILLSET OF SYNERGISTIC PROCESS TOOLS THAT FACILITATE BIDIRECTIONAL FEEDBACK AND INTEGRATION BETWEEN HIGH- AND LOW-LEVEL BRAIN NETWORKS, AND AFFERENT AND RE-AFFERENT INPUT FROM INTEROCEPTIVE PROCESSES (SOMATOSENSORY, VISCEROSENSORY, CHEMOSENSORY). FROM A PREDICTIVE CODING PERSPECTIVE WE PROPOSE A SHIFT TO PERCEPTUAL INFERENCE FOR STRESS MODULATION AND OPTIMAL SELF-REGULATION. WE DESCRIBE HOW THE PROCESSES THAT SUB-SERVE SELF-REGULATION BECOME MORE AUTOMATIZED AND EFFICIENT OVER TIME AND PRACTICE, REQUIRING LESS EFFORT TO INITIATE WHEN NECESSARY AND TERMINATE MORE RAPIDLY WHEN NO LONGER NEEDED. TO SUPPORT OUR PROPOSED MODEL, WE PRESENT THE AVAILABLE EVIDENCE FOR YOGA AFFECTING SELF-REGULATORY PATHWAYS, INTEGRATING EXISTING CONSTRUCTS FROM BEHAVIOR THEORY AND COGNITIVE NEUROSCIENCE WITH EMERGING YOGA AND MEDITATION RESEARCH. THIS PAPER IS INTENDED TO GUIDE FUTURE BASIC AND CLINICAL RESEARCH, SPECIFICALLY TARGETING AREAS OF DEVELOPMENT IN THE TREATMENT OF STRESS-MEDIATED PSYCHOLOGICAL DISORDERS. 2014 3 1639 27 MODULATION OF IMMUNE RESPONSES IN STRESS BY YOGA. STRESS IS A CONSTANT FACTOR IN TODAY'S FASTPACED LIFE THAT CAN JEOPARDIZE OUR HEALTH IF LEFT UNCHECKED. IT IS ONLY IN THE LAST HALF CENTURY THAT THE ROLE OF STRESS IN EVERY AILMENT FROM THE COMMON COLD TO AIDS HAS BEEN EMPHASIZED, AND THE MECHANISMS INVOLVED IN THIS PROCESS HAVE BEEN STUDIED. STRESS INFLUENCES THE IMMUNE RESPONSE PRESUMABLY THROUGH THE ACTIVATION OF THE HYPOTHALAMIC-PITUITARY ADRENAL AXIS, HYPOTHALAMIC PITUITARY-GONADAL AXIS, AND THE SYMPATHETIC-ADRENAL-MEDULLARY SYSTEM. VARIOUS NEUROTRANSMITTERS, NEUROPEPTIDES, HORMONES, AND CYTOKINES MEDIATE THESE COMPLEX BIDIRECTIONAL INTERACTIONS BETWEEN THE CENTRAL NERVOUS SYSTEM (CNS) AND THE IMMUNE SYSTEM. THE EFFECTS OF STRESS ON THE IMMUNE RESPONSES RESULT IN ALTERATIONS IN THE NUMBER OF IMMUNE CELLS AND CYTOKINE DYSREGULATION. VARIOUS STRESS MANAGEMENT STRATEGIES SUCH AS MEDITATION, YOGA, HYPNOSIS, AND MUSCLE RELAXATION HAVE BEEN SHOWN TO REDUCE THE PSYCHOLOGICAL AND PHYSIOLOGICAL EFFECTS OF STRESS IN CANCERS AND HIV INFECTION. THIS REVIEW AIMS TO DISCUSS THE EFFECT OF STRESS ON THE IMMUNE SYSTEM AND EXAMINE HOW RELAXATION TECHNIQUES SUCH AS YOGA AND MEDITATION COULD REGULATE THE CYTOKINE LEVELS AND HENCE, THE IMMUNE RESPONSES DURING STRESS. 2008 4 1335 28 HOW DOES YOGA PRACTICE AND THERAPY YIELD PSYCHOLOGICAL BENEFITS? A REVIEW AND MODEL OF TRANSDIAGNOSTIC PROCESSES. INTEREST IN YOGA AS AN INTERVENTION FOR PSYCHOLOGICAL WELLBEING HAS INCREASED IN RECENT YEARS, WITH LITERATURE INVESTIGATING BENEFICIAL EFFECTS IN A VARIETY OF PRESENTATIONS AND SETTINGS. THE THEORETICAL UNDERSTANDING OF THIS BENEFIT HAS PREVIOUSLY FOCUSED ON PHYSIOLOGICAL CHANGES INVOLVED IN YOGA PRACTICE, HOWEVER INTEREST HAS TURNED TO THE POTENTIAL PSYCHOLOGICAL MECHANISMS ELICITING PSYCHOLOGICAL WELLBEING. THE CURRENT PAPER BUILDS ON PREVIOUS THEORY AND ARGUES THAT YOGA PRACTICE TARGETS TRANSDIAGNOSTIC PSYCHOLOGICAL PROCESSES; MECHANISMS THAT FEATURE COMMONLY ACROSS A WIDE RANGE OF PRESENTATIONS, THUS REDUCING DISTRESS AND INCREASING WELLBEING ACROSS CLINICAL AND NON-CLINICAL POPULATIONS. FEATURES OF YOGA PRACTICE ARE DISCUSSED IN RELATION TO THESE TRANSDIAGNOSTIC PROCESSES AND THE FEATURES OF MODERN TALKING THERAPIES. A NEW MODEL IS PROPOSED POSITING SPECIFIC ASPECTS OF YOGA PRACTICE CORRELATE WITH SPECIFIC TRANSDIAGNOSTIC PROCESSES TO ELICIT PSYCHOLOGICAL CHANGE AND ARGUES THAT THE MECHANISMS BY WHICH CHANGE OCCURS ARE DIRECTLY COMPARED WITH THE CHANGES OBSERVED IN TALKING THERAPIES. THE IMPLICATIONS FOR FUTURE RESEARCH AND THE POTENTIAL FOR THIS TO SUPPORT THE COMMISSIONING OF HOLISTIC APPROACHES IN CLINICAL PRACTICE ARE DISCUSSED. 2022 5 1590 21 MEDITATION AND YOGA CAN MODULATE BRAIN MECHANISMS THAT AFFECT BEHAVIOR AND ANXIETY-A MODERN SCIENTIFIC PERSPECTIVE. MEDITATION AND YOGA TECHNIQUES ARE RECEIVING INCREASED ATTENTION THROUGHOUT THE WORLD, DUE TO THE ACCUMULATION OF EVIDENCE BASED RESEARCH THAT PROVES THE DIRECT AND INDIRECT BENEFITS OF SUCH PRACTICES. BASED ON STUDIES CONDUCTED SO FAR, IT HAS BEEN FOUND THAT THE PRACTICE OF MEDITATION TRIGGERS NEUROTRANSMITTERS THAT MODULATE PSYCHOLOGICAL DISORDERS SUCH AS ANXIETY. THIS PAPER WILL REVIEW THE PSYCHOLOGICAL EFFECTS OF THE PRACTICE OF MEDITATION, THE ROLE OF NEUROTRANSMITTERS, AND STUDIES USING EEG AND FMRI. 2015 6 1824 31 PSYCHO-NEURO-ENDOCRINE-IMMUNE MECHANISMS OF ACTION OF YOGA IN TYPE II DIABETES. YOGA HAS BEEN FOUND TO BENEFIT ALL THE COMPONENTS OF HEALTH VIZ. PHYSICAL, MENTAL, SOCIAL AND SPIRITUAL WELL BEING BY INCORPORATING A WIDE VARIETY OF PRACTICES. PATHOPHYSIOLOGY OF TYPE II DM AND CO-MORBIDITIES IN TYPE II DM HAS BEEN CORRELATED WITH STRESS MECHANISMS. STRESS SUPPRESSES BODY'S IMMUNE SYSTEM AND NEURO-HUMORAL ACTIONS THEREBY AFF ECTING NORMAL PSYCHOLOGICAL STATE. IT WOULD NOT BE WRONG TO STATE THAT CORRELATION OF DIABETES WITH STRESS, ANXIETY AND OTHER PSYCHOLOGICAL FACTORS ARE BIDIRECTIONAL AND LEAD TO DIFFICULTY IN UNDERSTANDING THE INTERRELATED MECHANISMS. TYPE II DM CANNOT BE UNDERSTOOD IN ISOLATION WITH PSYCHOLOGICAL FACTORS SUCH AS STRESS, ANXIETY AND DEPRESSION, NEURO-ENDOCRINE AND IMMUNOLOGICAL FACTORS. THERE IS NO REVIEW WHICH TRIES TO UNDERSTAND THESE MECHANISMS EXCLUSIVELY. THE PRESENT LITERATURE REVIEW AIMS TO UNDERSTAND INTERRELATED PSYCHO-NEURO-ENDOCRINE AND IMMUNOLOGICAL MECHANISMS OF ACTION OF YOGA IN TYPE II DIABETES MELLITUS. PUBLISHED LITERATURE CONCERNING MECHANISMS OF ACTION OF YOGA IN TYPE II DM EMPHASIZING PSYCHO-NEURO-ENDOCRINE OR IMMUNOLOGICAL RELATIONS WAS RETRIEVED FROM PUBMED USING KEY WORDS YOGA, TYPE II DIABETES MELLITUS, PSYCHOLOGICAL, NEURAL, ENDOCRINE, IMMUNE AND MECHANISM OF ACTION. THOSE STUDIES WHICH EXPLAINED THE PSYCHO-NEUROENDOCRINE AND IMMUNE MECHANISMS OF ACTION OF YOGA WERE INCLUDED AND REST WERE EXCLUDED. ALTHOUGH PRIMARY AIM OF THIS STUDY IS TO EXPLAIN THESE MECHANISMS IN TYPE II DM, SOME STUDIES IN NON-DIABETIC POPULATION WHICH HAD A SIMILAR PATHWAY OF STRESS MECHANISM WAS INCLUDED BECAUSE MANY INSIGHTFUL STUDIES WERE AVAILABLE IN THAT AREA. SEARCH WAS CONDUCTED USING TERMS YOGA OR YOGIC AND DIABETES OR DIABETIC IN TITLE OR ABSTRACT FOR ENGLISH ARTICLES. OF THE 89 ARTICLES, WE EXCLUDED NON-ENGLISH ARTICLES (22), EDITORIALS (20) AND LETTERS TO EDITOR (10). 37 STUDIES WERE CONSIDERED FOR THIS REVIEW. THE POSTULATED MECHANISM OF ACTION OF YOGA IS THROUGH PARASYMPATHETIC ACTIVATION AND THE ASSOCIATED ANTI STRESS MECHANISM. IT REDUCES PERCEIVED STRESS AND HPA AXIS ACTIVATION THEREBY IMPROVING OVERALL METABOLIC AND PSYCHOLOGICAL PROFILES, INCREASING INSULIN SENSITIVITY, AND IMPROVING GLUCOSE TOLERANCE AND LIPID METABOLISM. YOGA HAS POSITIVE EFFECTS ON IMMUNE SYSTEM OF DIABETICS.- OVERALL, TYPE II DM IS INFLUENCED BY PSYCHO-NEURO-ENDOCRINE AND IMMUNE MECHANISMS WHERE YOGA HAS IMPORTANT POSITIVE ROLE IN COMBATING STRESSORS AND IMPROVING THESE SYSTEMS TO REGAIN HEALTH. 2015 7 2608 20 YOGA FOR PSYCHIATRIC DISORDERS: FROM FAD TO EVIDENCE-BASED INTERVENTION? THERE IS GROWING EVIDENCE FOR YOGA'S NEUROBIOLOGICAL EFFECTS IN PEOPLE WITH PSYCHIATRIC DISORDERS. POSTULATED MECHANISMS OF ACTION INCLUDE: (A) MODULATION OF THE HYPOTHALAMIC-PITUITARY-ADRENAL (HPA) AXIS; (B) ENHANCEMENT OF GABAERGIC NEUROTRANSMISSION; (C) AUTONOMIC MODULATION; AND (D) NEUROENDOCRINOLOGICAL EFFECTS. YOGA AS A THERAPEUTIC INTERVENTION IN PSYCHIATRIC DISORDERS APPEARS PROMISING AND MERITS FURTHER ATTENTION IN CLINICAL PRACTICE AND RESEARCH. 2020 8 93 38 A NARRATIVE REVIEW OF YOGA AND MINDFULNESS AS COMPLEMENTARY THERAPIES FOR ADDICTION. THIS PAPER REVIEWS THE PHILOSOPHICAL ORIGINS, CURRENT SCIENTIFIC EVIDENCE, AND CLINICAL PROMISE OF YOGA AND MINDFULNESS AS COMPLEMENTARY THERAPIES FOR ADDICTION. HISTORICALLY, THERE ARE EIGHT ELEMENTS OF YOGA THAT, TOGETHER, COMPRISE ETHICAL PRINCIPLES AND PRACTICES FOR LIVING A MEANINGFUL, PURPOSEFUL, MORAL AND SELF-DISCIPLINED LIFE. TRADITIONAL YOGA PRACTICES, INCLUDING POSTURES AND MEDITATION, DIRECT ATTENTION TOWARD ONE'S HEALTH, WHILE ACKNOWLEDGING THE SPIRITUAL ASPECTS OF ONE'S NATURE. MINDFULNESS DERIVES FROM ANCIENT BUDDHIST PHILOSOPHY, AND MINDFULNESS MEDITATION PRACTICES, SUCH AS GENTLE HATHA YOGA AND MINDFUL BREATHING, ARE INCREASINGLY INTEGRATED INTO SECULAR HEALTH CARE SETTINGS. CURRENT THEORETICAL MODELS SUGGEST THAT THE SKILLS, INSIGHTS, AND SELF-AWARENESS LEARNED THROUGH YOGA AND MINDFULNESS PRACTICE CAN TARGET MULTIPLE PSYCHOLOGICAL, NEURAL, PHYSIOLOGICAL, AND BEHAVIORAL PROCESSES IMPLICATED IN ADDICTION AND RELAPSE. A SMALL BUT GROWING NUMBER OF WELL-DESIGNED CLINICAL TRIALS AND EXPERIMENTAL LABORATORY STUDIES ON SMOKING, ALCOHOL DEPENDENCE, AND ILLICIT SUBSTANCE USE SUPPORT THE CLINICAL EFFECTIVENESS AND HYPOTHESIZED MECHANISMS OF ACTION UNDERLYING MINDFULNESS-BASED INTERVENTIONS FOR TREATING ADDICTION. BECAUSE VERY FEW STUDIES HAVE BEEN CONDUCTED ON THE SPECIFIC ROLE OF YOGA IN TREATING OR PREVENTING ADDICTION, WE PROPOSE A CONCEPTUAL MODEL TO INFORM FUTURE STUDIES ON OUTCOMES AND POSSIBLE MECHANISMS. ADDITIONAL RESEARCH IS ALSO NEEDED TO BETTER UNDERSTAND WHAT TYPES OF YOGA AND MINDFULNESS-BASED INTERVENTIONS WORK BEST FOR WHAT TYPES OF ADDICTION, WHAT TYPES OF PATIENTS, AND UNDER WHAT CONDITIONS. OVERALL, CURRENT FINDINGS INCREASINGLY SUPPORT YOGA AND MINDFULNESS AS PROMISING COMPLEMENTARY THERAPIES FOR TREATING AND PREVENTING ADDICTIVE BEHAVIORS. 2013 9 1337 26 HOW DOES YOGA REDUCE STRESS? A SYSTEMATIC REVIEW OF MECHANISMS OF CHANGE AND GUIDE TO FUTURE INQUIRY. YOGA IS INCREASINGLY USED IN CLINICAL SETTINGS FOR A VARIETY OF MENTAL AND PHYSICAL HEALTH ISSUES, PARTICULARLY STRESS-RELATED ILLNESSES AND CONCERNS, AND HAS DEMONSTRATED PROMISING EFFICACY. YET THE WAYS IN WHICH YOGA REDUCES STRESS REMAIN POORLY UNDERSTOOD. TO EXAMINE THE EMPIRICAL EVIDENCE REGARDING THE MECHANISMS THROUGH WHICH YOGA REDUCES STRESS, WE CONDUCTED A SYSTEMATIC REVIEW OF THE LITERATURE, INCLUDING ANY YOGA INTERVENTION THAT MEASURED STRESS AS A PRIMARY DEPENDENT VARIABLE AND TESTED A MECHANISM OF THE RELATIONSHIP WITH MEDIATION. OUR ELECTRONIC DATABASE SEARCH YIELDED 926 ABSTRACTS, OF WHICH 71 WERE CHOSEN FOR FURTHER INSPECTION AND 5 WERE SELECTED FOR THE FINAL SYSTEMATIC REVIEW. THESE FIVE STUDIES EXAMINED THREE PSYCHOLOGICAL MECHANISMS (POSITIVE AFFECT, MINDFULNESS AND SELF-COMPASSION) AND FOUR BIOLOGICAL MECHANISMS (POSTERIOR HYPOTHALAMUS, INTERLEUKIN-6, C-REACTIVE PROTEIN AND CORTISOL). POSITIVE AFFECT, SELF-COMPASSION, INHIBITION OF THE POSTERIOR HYPOTHALAMUS AND SALIVARY CORTISOL WERE ALL SHOWN TO MEDIATE THE RELATIONSHIP BETWEEN YOGA AND STRESS. IT IS STRIKING THAT THE LITERATURE DESCRIBING POTENTIAL MECHANISMS IS GROWING RAPIDLY, YET ONLY SEVEN MECHANISMS HAVE BEEN EMPIRICALLY EXAMINED; MORE RESEARCH IS NECESSARY. ALSO, FUTURE RESEARCH OUGHT TO INCLUDE MORE RIGOROUS METHODOLOGY, INCLUDING SUFFICIENT POWER, STUDY RANDOMISATION AND APPROPRIATE CONTROL GROUPS. 2015 10 588 33 DETERMINING PSYCHONEUROIMMUNOLOGIC MARKERS OF YOGA AS AN INTERVENTION FOR PERSONS DIAGNOSED WITH PTSD: A SYSTEMATIC REVIEW. THERE IS A GROWING BODY OF RESEARCH ON YOGA AS A THERAPEUTIC INTERVENTION FOR PSYCHOLOGICAL SYMPTOMS OF POST-TRAUMATIC STRESS DISORDER (PTSD) ACCOMPANIED BY SPECULATIONS ON UNDERLYING PHYSIOLOGIC MECHANISMS. THE PURPOSE OF THIS SYSTEMATIC REVIEW IS TO IDENTIFY, QUALITATIVELY EVALUATE, AND SYNTHESIZE STUDIES OF YOGA AS AN INTERVENTION FOR PTSD THAT MEASURED PHYSIOLOGIC OUTCOMES IN ORDER TO GAIN INSIGHTS INTO POTENTIAL MECHANISMS. THE FOCUS IS ON STUDIES EVALUATING YOGA AS A THERAPEUTIC INTERVENTION FOR PTSD RATHER THAN FOR TRAUMA EXPOSURE, PTSD PREVENTION, OR SUBCLINICAL PTSD. MULTIPLE DATABASES WERE SEARCHED FOR PUBLICATIONS FROM THE PAST TWO DECADES USING TERMS DERIVED FROM THE QUESTION, "IN PEOPLE WITH PTSD, WHAT IS THE EFFECT OF YOGA ON OBJECTIVE OUTCOMES?" ELIGIBILITY CRITERIA INCLUDED YOGA-ONLY MODALITIES TESTED AS AN INTERVENTION FOR FORMALLY DIAGNOSED PTSD WITH AT LEAST ONE PHYSIOLOGIC OUTCOME. RESULTS OF THIS REVIEW CONFIRMED THAT, THOUGH MUCH OF THE PUBLISHED LITERATURE PROPOSES PHYSIOLOGICAL MECHANISMS UNDERLYING YOGA'S EFFECTS ON PTSD, VERY FEW STUDIES ( N = 3) HAVE ACTUALLY EVALUATED PHYSIOLOGICAL EVIDENCE. ADDITIONALLY, SEVERAL STUDIES HAD METHODOLOGICAL LIMITATIONS. IN LIGHT OF THE LIMITED DATA SUPPORTING YOGA'S BENEFICIAL EFFECTS ON AUTONOMIC NERVOUS SYSTEM DYSREGULATION, WE PRESENT A THEORETICAL MODEL OF THE PSYCHONEUROIMMUNOLOGIC PROCESSES ASSOCIATED WITH PTSD AND THE EFFECTS YOGA MAY HAVE ON THESE PROCESSES TO GUIDE FUTURE RESEARCH. GAPS IN THE LITERATURE REMAIN FOR MECHANISMS RELATED TO ACTIVATION OF THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS AND INFLAMMATION. ADDITIONAL RIGOROUS MECHANISTIC STUDIES ARE NEEDED TO GUIDE DEVELOPMENT OF EFFECTIVE YOGA INTERVENTIONS FOR PTSD TO AUGMENT EXISTING EVIDENCE-BASED PTSD TREATMENTS. 2018 11 76 26 A HEURISTIC MODEL LINKING YOGA PHILOSOPHY AND SELF-REFLECTION TO EXAMINE UNDERLYING MECHANISMS OF ADD-ON YOGA TREATMENT IN SCHIZOPHRENIA. PRELIMINARY EVIDENCE SUGGESTS EFFICACY OF YOGA AS ADD-ON TREATMENT FOR SCHIZOPHRENIA, BUT THE UNDERLYING MECHANISM BY WHICH YOGA IMPROVES THE SYMPTOMS OF SCHIZOPHRENIA IS NOT COMPLETELY UNDERSTOOD. YOGA IMPROVES SELF-REFLECTION IN HEALTHY INDIVIDUALS, AND SELF-REFLECTION ABNORMALITIES ARE TYPICALLY SEEN IN SCHIZOPHRENIA. HOWEVER, WHETHER YOGA TREATMENT IMPROVES IMPAIRMENTS IN SELF-REFLECTION TYPICALLY SEEN IN PATIENTS WITH SCHIZOPHRENIA IS NOT EXAMINED. THIS PAPER DISCUSSES THE POTENTIAL MECHANISM OF YOGA IN THE TREATMENT OF SCHIZOPHRENIA AND PROPOSES A TESTABLE HYPOTHESIS FOR FURTHER EMPIRICAL STUDIES. IT IS PROPOSED THAT SELF-REFLECTION ABNORMALITIES IN SCHIZOPHRENIA IMPROVE WITH YOGA AND THE NEUROBIOLOGICAL CHANGES ASSOCIATED WITH THIS CAN BE EXAMINED USING EMPIRICAL BEHAVIOURAL MEASURES AND NEUROIMAGING MEASURES SUCH AS MAGNETIC RESONANCE IMAGING. 2016 12 422 34 BRIDGING THE SCHISM OF SCHIZOPHRENIA THROUGH YOGA-REVIEW OF PUTATIVE MECHANISMS. SCHIZOPHRENIA PATIENTS EXPERIENCE A 'DISCONNECT' AT MULTIPLE LEVELS-NEURONAL NETWORKS, MENTAL PROCESSES, AND INTERPERSONAL RELATIONSHIPS. THE RESULTANT POOR QUALITY-OF-LIFE AND FUNCTIONAL DISABILITY ARE RELATED TO THE PERSISTENT COGNITIVE DEFICITS AND NEGATIVE SYMPTOMS, WHICH ARE RATHER RESISTANT TO CONVENTIONAL ANTIPSYCHOTIC MEDICATIONS. YOGA HAS EMERGED AS AN IMPORTANT THERAPEUTIC INTERVENTION TO IMPROVE QUALITY-OF-LIFE IN SCHIZOPHRENIA. RECENT PRELIMINARY EVIDENCE SUGGESTS THAT EFFECTS OF YOGA ON COGNITIVE AND NEGATIVE SYMPTOMS MAY DRIVE THIS BENEFIT. THIS STUDY ATTEMPTS TO INTEGRATE EVIDENCE FROM NEUROSCIENCE-BASED RESEARCH, WHICH FOCUSES ON THE NEUROPLASTICITY-HARNESSING EFFECTS OF YOGA TO BRIDGE THE SCHIZOPHRENIA CONNECTOPATHY. IN AN OVERARCHING MODEL TO STUDY PUTATIVE NEUROBIOLOGICAL MECHANISMS THAT DRIVE THERAPEUTIC EFFECTS OF YOGA, IT IS PROPOSED THAT (A) VARIOUS STYLES OF MEDITATION MAY HELP IN STRENGTHENING THE LATERAL AND MEDIAL PREFRONTAL BRAIN NETWORKS, THUS IMPROVING NEUROCOGNITION AND MENTALIZING ABILITIES, AND (B) LEARNING AND PERFORMING CO-ORDINATED PHYSICAL POSTURES WITH A TEACHER FACILITATES IMITATION AND THE PROCESS OF BEING IMITATED, WHICH CAN IMPROVE SOCIAL COGNITION AND EMPATHY THROUGH REINFORCEMENT OF THE PREMOTOR AND PARIETAL MIRROR NEURON SYSTEM. OXYTOCIN MAY PLAY A ROLE IN MEDIATING THESE PROCESSES, LEADING TO BETTER SOCIAL CONNECTEDNESS AND SOCIAL OUTCOMES. CLINICAL AND HEURISTIC IMPLICATIONS OF THIS MODEL ARE FURTHER DISCUSSED. 2016 13 226 29 A SYSTEMATIC REVIEW OF RANDOMISED CONTROL TRIALS ON THE EFFECTS OF YOGA ON STRESS MEASURES AND MOOD. STRESS RELATED DISORDERS SUCH AS DEPRESSION AND ANXIETY ARE LEADING SOURCES OF DISABILITY WORLDWIDE, AND CURRENT TREATMENT METHODS SUCH AS CONVENTIONAL ANTIDEPRESSANT MEDICATIONS ARE NOT BENEFICIAL FOR ALL INDIVIDUALS. THERE IS EVIDENCE THAT YOGA HAS MOOD-ENHANCING PROPERTIES POSSIBLY RELATED TO ITS INHIBITORY EFFECTS ON PHYSIOLOGICAL STRESS AND INFLAMMATION, WHICH ARE FREQUENTLY ASSOCIATED WITH AFFECTIVE DISORDERS. HOWEVER THE BIOLOGICAL MECHANISMS VIA WHICH YOGA EXERTS ITS THERAPEUTIC MOOD-MODULATING EFFECTS ARE LARGELY UNKNOWN. THIS SYSTEMATIC REVIEW INVESTIGATES THE EFFECTS OF YOGA ON SYMPATHETIC NERVOUS SYSTEM AND HYPOTHALAMIC PITUITARY ADRENAL AXIS REGULATION MEASURES. IT FOCUSES ON STUDIES COLLECTING PHYSIOLOGICAL PARAMETERS SUCH AS BLOOD PRESSURE, HEART RATE, CORTISOL, PERIPHERAL CYTOKINE EXPRESSION AND/OR STRUCTURAL AND FUNCTIONAL BRAIN MEASURES IN REGIONS INVOLVED IN STRESS AND MOOD REGULATION. OVERALL THE 25 RANDOMISED CONTROL STUDIES DISCUSSED PROVIDE PRELIMINARY EVIDENCE TO SUGGEST THAT YOGA PRACTICE LEADS TO BETTER REGULATION OF THE SYMPATHETIC NERVOUS SYSTEM AND HYPOTHALAMIC-PITUITARY-ADRENAL SYSTEM, AS WELL AS A DECREASE IN DEPRESSIVE AND ANXIOUS SYMPTOMS IN A RANGE OF POPULATIONS. FURTHER RESEARCH IS WARRANTED TO CONFIRM THESE PRELIMINARY FINDINGS AND FACILITATE IMPLEMENTATION IN CLINICAL SETTINGS. 2015 14 2886 33 YOGA: BALANCING THE EXCITATION-INHIBITION EQUILIBRIUM IN PSYCHIATRIC DISORDERS. SOCIAL BEHAVIORAL DISTURBANCES ARE CENTRAL TO MOST PSYCHIATRIC DISORDERS. A DISEQUILIBRIUM WITHIN THE CORTICAL EXCITATORY AND INHIBITORY NEUROTRANSMITTER SYSTEMS UNDERLIES THESE DEFICITS. GAMMA-AMINOBUTYRIC ACID (GABA) AND GLUTAMATE ARE THE MOST ABUNDANT EXCITATORY AND INHIBITORY NEUROTRANSMITTERS IN THE BRAIN THAT CONTRIBUTE TO THIS EQUILIBRIUM. SEVERAL CONTEMPORARY THERAPIES USED IN TREATING PSYCHIATRIC DISORDERS, REGULATE THIS GABA-GLUTAMATE BALANCE. YOGA HAS BEEN STUDIED AS AN ADJUVANT TREATMENT ACROSS A BROAD RANGE OF PSYCHIATRIC DISORDERS AND IS SHOWN TO HAVE SHORT-TERM THERAPEUTIC GAINS. EMERGING EVIDENCE FROM RECENT CLINICAL IN VIVO EXPERIMENTS SUGGESTS THAT YOGA IMPROVES GABA-MEDIATED CORTICAL-INHIBITORY TONE AND ENHANCES PERIPHERAL OXYTOCIN LEVELS. THIS IS LIKELY TO HAVE A MORE CONTROLLED DOWNSTREAM RESPONSE OF THE HYPOTHALAMO-PITUITARY-ADRENAL SYSTEM BY MEANS OF REDUCED CORTISOL RELEASE AND HENCE A BLUNTED SYMPATHETIC RESPONSE TO STRESS. ANIMAL AND EARLY FETAL DEVELOPMENTAL STUDIES SUGGEST AN INTER-DEPENDENT ROLE OF OXYTOCIN AND GABA IN REGULATING SOCIAL BEHAVIORS. IN KEEPING WITH THESE OBSERVATIONS, WE PROPOSE AN INTEGRATED NEUROBIOLOGICAL MODEL TO STUDY THE MECHANISMS OF THERAPEUTIC BENEFITS WITH YOGA. APART FROM PROVIDING A NEUROSCIENTIFIC BASIS FOR APPLYING A TRADITIONAL SYSTEM OF PRACTICE IN THE CLINICAL SETTING, THIS MODEL CAN BE USED AS A FRAMEWORK FOR STUDYING YOGA MECHANISMS IN FUTURE CLINICAL TRIALS. 2019 15 2781 44 YOGA THERAPY AND POLYVAGAL THEORY: THE CONVERGENCE OF TRADITIONAL WISDOM AND CONTEMPORARY NEUROSCIENCE FOR SELF-REGULATION AND RESILIENCE. YOGA THERAPY IS A NEWLY EMERGING, SELF-REGULATING COMPLEMENTARY AND INTEGRATIVE HEALTHCARE (CIH) PRACTICE. IT IS GROWING IN ITS PROFESSIONALIZATION, RECOGNITION AND UTILIZATION WITH A DEMONSTRATED COMMITMENT TO SETTING PRACTICE STANDARDS, EDUCATIONAL AND ACCREDITATION STANDARDS, AND PROMOTING RESEARCH TO SUPPORT ITS EFFICACY FOR VARIOUS POPULATIONS AND CONDITIONS. HOWEVER, HETEROGENEITY OF PRACTICE, POOR REPORTING STANDARDS, AND LACK OF A BROADLY ACCEPTED UNDERSTANDING OF THE NEUROPHYSIOLOGICAL MECHANISMS INVOLVED IN YOGA THERAPY LIMITS THE STRUCTURING OF TESTABLE HYPOTHESES AND CLINICAL APPLICATIONS. CURRENT PROPOSED FRAMEWORKS OF YOGA-BASED PRACTICES FOCUS ON THE INTEGRATION OF BOTTOM-UP NEUROPHYSIOLOGICAL AND TOP-DOWN NEUROCOGNITIVE MECHANISMS. IN ADDITION, IT HAS BEEN PROPOSED THAT PHENOMENOLOGY AND FIRST PERSON ETHICAL INQUIRY CAN PROVIDE A LENS THROUGH WHICH YOGA THERAPY IS VIEWED AS A PROCESS THAT CONTRIBUTES TOWARDS EUDAIMONIC WELL-BEING IN THE EXPERIENCE OF PAIN, ILLNESS OR DISABILITY. IN THIS ARTICLE WE BUILD ON THESE FRAMEWORKS, AND PROPOSE A MODEL OF YOGA THERAPY THAT CONVERGES WITH POLYVAGAL THEORY (PVT). PVT LINKS THE EVOLUTION OF THE AUTONOMIC NERVOUS SYSTEM TO THE EMERGENCE OF PROSOCIAL BEHAVIORS AND POSITS THAT THE NEURAL PLATFORMS SUPPORTING SOCIAL BEHAVIOR ARE INVOLVED IN MAINTAINING HEALTH, GROWTH AND RESTORATION. THIS EXPLANATORY MODEL WHICH CONNECTS NEUROPHYSIOLOGICAL PATTERNS OF AUTONOMIC REGULATION AND EXPRESSION OF EMOTIONAL AND SOCIAL BEHAVIOR, IS INCREASINGLY UTILIZED AS A FRAMEWORK FOR UNDERSTANDING HUMAN BEHAVIOR, STRESS AND ILLNESS. SPECIFICALLY, WE DESCRIBE HOW PVT CAN BE CONCEPTUALIZED AS A NEUROPHYSIOLOGICAL COUNTERPART TO THE YOGIC CONCEPT OF THE GUNAS, OR QUALITIES OF NATURE. SIMILAR TO THE NEURAL PLATFORMS DESCRIBED IN PVT, THE GUNAS PROVIDE THE FOUNDATION FROM WHICH BEHAVIORAL, EMOTIONAL AND PHYSICAL ATTRIBUTES EMERGE. WE DESCRIBE HOW THESE TWO DIFFERENT YET ANALOGOUS FRAMEWORKS-ONE BASED IN NEUROPHYSIOLOGY AND THE OTHER IN AN ANCIENT WISDOM TRADITION-HIGHLIGHT YOGA THERAPY'S PROMOTION OF PHYSICAL, MENTAL AND SOCIAL WELLBEING FOR SELF-REGULATION AND RESILIENCE. THIS PARALLEL BETWEEN THE NEURAL PLATFORMS OF PVT AND THE GUNAS OF YOGA IS INSTRUMENTAL IN CREATING A TRANSLATIONAL FRAMEWORK FOR YOGA THERAPY TO ALIGN WITH ITS PHILOSOPHICAL FOUNDATIONS. CONSEQUENTLY, YOGA THERAPY CAN OPERATE AS A DISTINCT PRACTICE RATHER THAN FITTING INTO AN OUTSIDE MODEL FOR ITS UTILIZATION IN RESEARCH AND CLINICAL CONTEXTS. 2018 16 1890 31 REGULATION OF GENE EXPRESSION BY YOGA, MEDITATION AND RELATED PRACTICES: A REVIEW OF RECENT STUDIES. INTEGRATIVE MEDICINE (IM) APPROACHES HAVE GAINED SIGNIFICANT INTEREST IN RECENT YEARS TO PROVIDE A SOLUTION FOR THE HEALTH CARE CHALLENGES WE FACE TODAY. YOGIC COGNITIVE-BEHAVIORAL PRACTICES ARE AMONG THE MOST WIDELY USED IM APPROACHES AND INCLUDE DIVERSE PRACTICES SUCH AS YOGA ASANAS, MEDITATION, BREATHING EXERCISES, QI GONG, TAI CHI CHIH, AND VARIOUS OTHERS. STUDIES TO DATE SUGGEST THAT THESE YOGIC/MEDITATIVE PRACTICES HAVE SIGNIFICANT POSITIVE EFFECTS ON THE MIND-BODY SYSTEM AND THEREBY CAN INCREASE WELLNESS AND SUPPORT THE HEALING PROCESS FROM DISEASE. PREVIOUS WORK HAS PROVIDED EVIDENCE FOR BOTH PSYCHOLOGICAL AND PHYSIOLOGICAL EFFECTS OF THESE PRACTICES; HOWEVER, THE MECHANISMS OF THESE EFFECTS, ESPECIALLY AT THE MOLECULAR LEVEL, HAVE LARGELY BEEN MISSING. THREE RECENT STUDIES STARTED TO PROVIDE SOME OF THIS INFORMATION THROUGH GENE EXPRESSION PROFILING IN CIRCULATING IMMUNE CELLS, WHICH SUPPORT THE HYPOTHESIS THAT YOGIC/MEDITATIVE PRACTICES HAVE A MEASURABLE EFFECT AT THE MOLECULAR LEVEL. THESE STUDIES ARE REVIEWED HEREIN AND SOME FUTURE PERSPECTIVES ARE CONSIDERED. 2013 17 65 28 A CONCEPTUAL MODEL DESCRIBING MECHANISMS FOR HOW YOGA PRACTICE MAY SUPPORT POSITIVE EMBODIMENT. YOGA PRACTICE HAS BEEN ASSOCIATED WITH VARIOUS INDICES OF POSITIVE EMBODIMENT IN CORRELATIONAL AND INTERVENTION STUDIES. YET, SYSTEMATIC, THEORETICALLY-GROUNDED MODELS DETAILING SPECIFIC MECHANISMS BY WHICH YOGA SUPPORTS POSITIVE EMBODIMENT ARE LACKING. IN THIS ARTICLE, WE PRESENT A CONCEPTUAL MODEL THAT DESCRIBES MECHANISMS (I.E., MEDIATORS AND MODERATORS) THAT CAN BE USED TO GUIDE RESEARCH TO HELP ANSWER HOW, FOR WHOM, AND UNDER WHAT CONDITIONS YOGA PRACTICE MAY PROMOTE POSITIVE EMBODIMENT. BASED ON EXISTING THEORETICAL FRAMEWORKS AND EMPIRICAL FINDINGS, THIS MODEL SUGGESTS THAT (A) YOGA PRACTICE MAY CULTIVATE EMBODYING EXPERIENCES DURING YOGA (E.G., STATE MINDFULNESS), (B) THESE EMBODYING EXPERIENCES MAY BUILD STABLE EMBODYING EXPERIENCES THAT GENERALIZE BEYOND THE YOGA CONTEXT (E.G., TRAIT MINDFULNESS), AND (C) THESE STABLE EMBODYING EXPERIENCES MAY THEN PROMOTE EMBODYING PRACTICES (E.G., MINDFUL SELF-CARE). THIS MEDIATIONAL CHAIN IS LIKELY MODERATED BY THE YOGA CONTEXT (E.G., INSTRUCTIONAL FOCUS, PRESENCE OF MIRRORS, DIVERSITY OF BODIES REPRESENTED) AND YOGA PRACTITIONERS' SOCIAL IDENTITIES (E.G., BODY SIZE, PHYSICAL LIMITATIONS), SOCIAL AND PERSONAL HISTORIES (E.G., EXPERIENCES WITH WEIGHT STIGMA AND TRAUMA), AND PERSONALITY TRAITS AND MOTIVES (E.G., BODY COMPARISON, APPEARANCE-FOCUSED MOTIVES TO PRACTICE YOGA). USING THE STRUCTURE OF THIS CONCEPTUAL MODEL, WE OFFER RESEARCHERS IDEAS FOR TESTABLE MODELS AND STUDY DESIGNS THAT CAN SUPPORT THEM. 2020 18 1640 34 MOLECULAR SIGNATURE OF THE IMMUNE RESPONSE TO YOGA THERAPY IN STRESS-RELATED CHRONIC DISEASE CONDITIONS: AN INSIGHT. THE WORLD HEALTH ORGANIZATION DEFINES HEALTH AS COMPLETE WELL-BEING IN TERMS OF PHYSICAL, MENTAL AND SOCIAL, AND NOT MERELY THE ABSENCE OF DISEASE. TO ATTAIN THIS, INDIVIDUAL SHOULD ADAPT AND SELF-MANGE THE SOCIAL, PHYSICAL AND EMOTIONAL CHALLENGES OF LIFE. EXPOSURE TO CHRONIC STRESS DUE TO URBANIZATION, WORK STRESS, NUCLEAR FAMILY, POLLUTION, UNHEALTHY FOOD HABITS, LIFESTYLE, ACCIDENTAL DEATH IN THE FAMILY, AND NATURAL CALAMITIES ARE THE TRIGGERING FACTORS, LEADING TO HORMONAL IMBALANCE AND INFLAMMATION IN THE TISSUE. THE RELATIONSHIP BETWEEN STRESS AND ILLNESS IS COMPLEX; ALL CHRONIC ILLNESSES SUCH AS CARDIOVASCULAR DISEASE AND ASTHMA HAVE THEIR ROOT IN CHRONIC STRESS ATTRIBUTED BY INFLAMMATION. IN RECENT TIMES, YOGA THERAPY HAS EMERGED AS AN IMPORTANT COMPLEMENTARY ALTERNATIVE MEDICINE FOR MANY HUMAN DISEASES. YOGA THERAPY HAS A POSITIVE IMPACT ON MIND AND BODY; IT ACTS BY INCORPORATING APPROPRIATE BREATHING TECHNIQUES AND MINDFULNESS TO ATTAIN CONSCIOUS DIRECTION OF OUR AWARENESS OF THE PRESENT MOMENT BY MEDITATION, WHICH HELPS ACHIEVE HARMONY BETWEEN THE BODY AND MIND. STUDIES HAVE ALSO DEMONSTRATED THE IMPORTANT REGULATORY EFFECTS OF YOGA THERAPY ON BRAIN STRUCTURE AND FUNCTIONS. DESPITE THESE ADVANCES, THE CELLULAR AND MOLECULAR MECHANISMS BY WHICH YOGA THERAPY RENDERS ITS BENEFICIAL EFFECTS ARE INADEQUATELY KNOWN. A GROWING BODY OF EVIDENCE SUGGESTS THAT YOGA THERAPY HAS IMMUNOMODULATORY EFFECTS. HOWEVER, THE PRECISE MECHANISTIC BASIS HAS NOT BEEN ADDRESSED EMPIRICALLY. IN THIS REVIEW, WE HAVE ATTEMPTED TO HIGHLIGHT THE EFFECT OF YOGA THERAPY ON IMMUNE SYSTEM FUNCTIONING WITH AN AIM TO IDENTIFY IMPORTANT IMMUNOLOGICAL SIGNATURES THAT INDEX THE EFFECT OF YOGA THERAPY. TOWARD THIS, WE HAVE SUMMARIZED THE AVAILABLE SCIENTIFIC EVIDENCE SHOWING POSITIVE IMPACTS OF YOGA THERAPY. FINALLY, WE HAVE EMPHASIZED THE EFFICACY OF YOGA IN IMPROVING PHYSICAL AND MENTAL WELL-BEING. YOGA HAS BEEN A PART OF INDIAN CULTURE AND TRADITION FOR LONG; NOW, THE TIME HAS COME TO SCIENTIFICALLY VALIDATE THIS AND IMPLEMENT THIS AS AN ALTERNATIVE TREATMENT METHOD FOR STRESS-RELATED CHRONIC DISEASE. 2020 19 1347 41 HYPOXIA IN CNS PATHOLOGIES: EMERGING ROLE OF MIRNA-BASED NEUROTHERAPEUTICS AND YOGA BASED ALTERNATIVE THERAPIES. CELLULAR RESPIRATION IS A VITAL PROCESS FOR THE EXISTENCE OF LIFE. ANY CONDITION THAT RESULTS IN DEPRIVATION OF OXYGEN (ALSO TERMED AS HYPOXIA) MAY EVENTUALLY LEAD TO DELETERIOUS EFFECTS ON THE FUNCTIONING OF TISSUES. BRAIN BEING THE HIGHEST CONSUMER OF OXYGEN IS PRONE TO INCREASED RISK OF HYPOXIA-INDUCED NEUROLOGICAL INSULTS. THIS IN TURN HAS BEEN ASSOCIATED WITH MANY DISEASES OF CENTRAL NERVOUS SYSTEM (CNS) SUCH AS STROKE, ALZHEIMER'S, ENCEPHALOPATHY ETC. ALTHOUGH SEVERAL STUDIES HAVE INVESTIGATED THE PATHOPHYSIOLOGICAL MECHANISMS UNDERLYING ISCHEMIC/HYPOXIC CNS DISEASES, THE KNOWLEDGE ABOUT PROTECTIVE THERAPEUTIC STRATEGIES TO AMELIORATE THE AFFECTED NEURONAL CELLS IS MEAGER. THIS HAS AUGMENTED THE NEED TO IMPROVE OUR UNDERSTANDING OF THE HYPOXIC AND ISCHEMIC EVENTS OCCURRING IN THE BRAIN AND IDENTIFY NOVEL AND ALTERNATE TREATMENT MODALITIES FOR SUCH INSULTS. MICRORNA (MIRNAS), SMALL NON-CODING RNA MOLECULES, HAVE RECENTLY EMERGED AS POTENTIAL NEUROPROTECTIVE AGENTS AS WELL AS TARGETS, UNDER HYPOXIC CONDITIONS. THESE 18-22 NUCLEOTIDE LONG RNA MOLECULES ARE PROFUSELY PRESENT IN BRAIN AND OTHER ORGANS AND FUNCTION AS GENE REGULATORS BY CLEAVING AND SILENCING THE GENE EXPRESSION. IN BRAIN, THESE ARE KNOWN TO BE INVOLVED IN NEURONAL DIFFERENTIATION AND PLASTICITY. THEREFORE, TARGETING MIRNA EXPRESSION REPRESENTS A NOVEL THERAPEUTIC APPROACH TO INTERCEDE AGAINST HYPOXIC AND ISCHEMIC BRAIN INJURY. IN THE FIRST PART OF THIS REVIEW, WE WILL DISCUSS THE NEUROPHYSIOLOGICAL CHANGES CAUSED AS A RESULT OF HYPOXIA, FOLLOWED BY THE CONTRIBUTION OF HYPOXIA IN THE NEURODEGENERATIVE DISEASES. SECONDLY, WE WILL PROVIDE RECENT UPDATES AND INSIGHTS INTO THE ROLES OF MIRNA IN THE REGULATION OF GENES IN OXYGEN AND GLUCOSE DEPRIVED BRAIN IN ASSOCIATION WITH CIRCADIAN RHYTHMS AND HOW THESE CAN BE TARGETED AS NEUROPROTECTIVE AGENTS FOR CNS INJURIES. FINALLY, WE WILL EMPHASIZE ON ALTERNATE BREATHING OR YOGIC INTERVENTIONS TO OVERCOME THE HYPOXIA ASSOCIATED ANOMALIES THAT COULD ULTIMATELY LEAD TO IMPROVEMENT IN CEREBRAL PERFUSION. 2017 20 2445 18 YOGA AND SUBSTANCE USE DISORDERS: A NARRATIVE REVIEW. YOGA HAS BEEN UTILIZED FOR PROMOTION OF HEALTH AND ALLEVIATING DISTRESS. IT HAS ALSO BEEN USED AS A THERAPEUTIC MEASURE IN THE FIELD OF MENTAL HEALTH, INCLUDING SUBSTANCE USE DISORDERS. THIS NARRATIVE REVIEW DISCUSSES THE LITERATURE PERTAINING TO USE OF YOGA IN THE TREATMENT OF SUBSTANCE USE DISORDERS. THE EVIDENCE BASE ESPECIALLY WITH REGARDS TO RANDOMIZED TRIALS IS PRESENTED. THE POSSIBLE MECHANISMS HOW YOGA MIGHT BE HELPFUL IN THE TREATMENT OF SUBSTANCE USE DISORDERS ARE EXPLORED. SUBSEQUENTLY, IMPLICATIONS OF YOGA IN CLINICAL PRACTICE ARE ELABORATED, FOLLOWED BY EXAMINATION OF THE ISSUES IN INTERPRETATION OF THE LITERATURE OF PUBLISHED YOGA RELATED STUDIES. 2017