1  451 165 CHANGES IN FATIGUE, AUTONOMIC FUNCTIONS, AND BLOOD BIOMARKERS DUE TO SITTING ISOMETRIC YOGA IN PATIENTS WITH CHRONIC FATIGUE SYNDROME. BACKGROUND: IN A PREVIOUS RANDOMIZED CONTROLLED TRIAL, WE FOUND THAT SITTING ISOMETRIC YOGA IMPROVES FATIGUE IN PATIENTS WITH CHRONIC FATIGUE SYNDROME (CFS) WHO ARE RESISTANT TO CONVENTIONAL THERAPY. THE AIM OF THIS STUDY WAS TO INVESTIGATE POSSIBLE MECHANISMS BEHIND THIS FINDING, FOCUSING ON THE SHORT-TERM FATIGUE-RELIEVING EFFECT, BY COMPARING AUTONOMIC NERVOUS FUNCTION AND BLOOD BIOMARKERS BEFORE AND AFTER A SESSION OF ISOMETRIC YOGA. METHODS: FIFTEEN PATIENTS WITH CFS WHO REMAINED SYMPTOMATIC DESPITE AT LEAST 6 MONTHS OF CONVENTIONAL THERAPY PRACTICED SITTING ISOMETRIC YOGA (BIWEEKLY 20 MIN PRACTICE WITH A YOGA INSTRUCTOR AND DAILY HOME PRACTICE) FOR EIGHT WEEKS. ACUTE EFFECTS OF SITTING ISOMETRIC YOGA ON FATIGUE, AUTONOMIC FUNCTION, AND BLOOD BIOMARKERS WERE INVESTIGATED AFTER THE FINAL SESSION WITH AN INSTRUCTOR. THE EFFECT OF A SINGLE SESSION OF SITTING ISOMETRIC YOGA ON FATIGUE WAS ASSESSED BY THE PROFILE OF MOOD STATUS (POMS) QUESTIONNAIRE IMMEDIATELY BEFORE AND AFTER THE SESSION. AUTONOMIC NERVOUS FUNCTION (HEART RATE (HR) VARIABILITY) AND BLOOD BIOMARKERS (CORTISOL, DHEA-S, TNF-ALPHA, IL-6, IFN-GAMMA, IFN-ALPHA, PROLACTIN, CARNITINE, TGF-BETA1, BDNF, MHPG, AND HVA) WERE COMPARED BEFORE AND AFTER THE SESSION. RESULTS: SITTING ISOMETRIC YOGA SIGNIFICANTLY REDUCED THE POMS FATIGUE SCORE (P < 0.01) AND INCREASED THE VIGOR SCORE (P < 0.01). IT ALSO REDUCED HR (P < 0.05) AND INCREASED THE HIGH FREQUENCY POWER (P < 0.05) OF HR VARIABILITY. SITTING ISOMETRIC YOGA INCREASED SERUM LEVELS OF DHEA-S (P < 0.05), REDUCED LEVELS OF CORTISOL (P < 0.05) AND TNF-ALPHA (P < 0.05), AND HAD A TENDENCY TO REDUCE SERUM LEVELS OF PROLACTIN (P < 0.1). DECREASES IN FATIGUE SCORES CORRELATED WITH CHANGES IN PLASMA LEVELS OF TGF-BETA1 AND BDNF. IN CONTRAST, INCREASED VIGOR POSITIVELY CORRELATED WITH HVA. CONCLUSIONS: A SINGLE SESSION OF SITTING ISOMETRIC YOGA REDUCED FATIGUE AND INCREASED VIGOR IN PATIENTS WITH CFS. YOGA ALSO INCREASED VAGAL NERVE FUNCTION AND CHANGED BLOOD BIOMARKERS IN A PATTERN THAT SUGGESTED ANTI-STRESS AND ANTI-INFLAMMATORY EFFECTS. THESE CHANGES APPEAR TO BE RELATED TO THE SHORT-TERM FATIGUE-RELIEVING EFFECT OF SITTING ISOMETRIC YOGA IN PATIENTS WITH CFS. FURTHERMORE, DOPAMINERGIC NERVOUS SYSTEM ACTIVATION MIGHT ACCOUNT FOR SITTING ISOMETRIC YOGA-INDUCED INCREASES IN ENERGY IN THIS PATIENT POPULATION. TRIAL REGISTRATION: UNIVERSITY HOSPITAL MEDICAL INFORMATION NETWORK (UMIN CTR) UMIN000009646. REGISTERED DEC 27, 2012.	2018	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
2 2250 111 THE LONGITUDINAL EFFECTS OF SEATED ISOMETRIC YOGA ON BLOOD BIOMARKERS, AUTONOMIC FUNCTIONS, AND PSYCHOLOGICAL PARAMETERS OF PATIENTS WITH CHRONIC FATIGUE SYNDROME: A PILOT STUDY. BACKGROUND: IN A PREVIOUS RANDOMIZED CONTROLLED TRIAL, WE FOUND THAT PRACTICING SEATED ISOMETRIC YOGA REGULARLY FOR 2 MONTHS IMPROVED THE FATIGUE OF PATIENTS WITH CHRONIC FATIGUE SYNDROME (CFS) WHO ARE RESISTANT TO CONVENTIONAL THERAPY. THE AIM OF THIS PILOT STUDY WAS TO INVESTIGATE THE POSSIBLE MECHANISMS BEHIND THIS FINDING BY COMPARING BLOOD BIOMARKERS, AUTONOMIC NERVOUS FUNCTION, AND PSYCHOLOGICAL INDICES BEFORE VERSUS AFTER AN INTERVENTION PERIOD OF SEATED ISOMETRIC YOGA PRACTICE. METHODS: FIFTEEN PATIENTS WITH CFS WHO DID NOT SHOW SATISFACTORY IMPROVEMENTS AFTER AT LEAST 6 MONTHS OF CONVENTIONAL THERAPY PRACTICED SEATED ISOMETRIC YOGA (BIWEEKLY 20-MIN SESSIONS WITH A YOGA INSTRUCTOR AND DAILY PRACTICE AT HOME) FOR 2 MONTHS. THE LONGITUDINAL EFFECTS OF SEATED ISOMETRIC YOGA ON FATIGUE, BLOOD BIOMARKERS, AUTONOMIC FUNCTION, AND PSYCHOLOGICAL STATE WERE INVESTIGATED BY COMPARING THE FOLLOWING PARAMETERS BEFORE AND AFTER THE INTERVENTION PERIOD: FATIGUE SEVERITY WAS ASSESSED BY THE CHALDER FATIGUE SCALE (FS) SCORE. LEVELS OF THE BLOOD BIOMARKERS CORTISOL, DHEA-S, TNF-ALPHA, IL-6, PROLACTIN, CARNITINE, TGF-BETA1, BDNF, MHPG, HVA, AND ALPHA-MSH WERE MEASURED. THE AUTONOMIC NERVOUS FUNCTIONS ASSESSED WERE HEART RATE (HR) AND HR VARIABILITY. PSYCHOLOGICAL INDICES INCLUDED THE 20-ITEM TORONTO ALEXITHYMIA SCALE (TAS-20) AND THE HOSPITAL ANXIETY AND DEPRESSION SCALE (HADS). RESULTS: PRACTICING SEATED ISOMETRIC YOGA FOR 2 MONTHS RESULTED IN SIGNIFICANT REDUCTIONS IN THE CHALDER FS (P = 0.002) AND HADS-DEPRESSION (P = 0.02) SCORES. NO SIGNIFICANT CHANGES WERE OBSERVED IN ANY OTHER PARAMETER EVALUATED. THE CHANGE IN CHALDER FS SCORE WAS NOT CORRELATED WITH THE CHANGE IN HADS-DEPRESSION SCORE. HOWEVER, THIS CHANGE WAS POSITIVELY CORRELATED WITH CHANGES IN THE SERUM TNF-ALPHA LEVELS (P = 0.048), THE HIGH FREQUENCY COMPONENT OF HR VARIABILITY (P = 0.042), AND TAS-20 SCORES (P = 0.001). CONCLUSIONS: REGULAR PRACTICE OF SEATED ISOMETRIC YOGA FOR 2 MONTHS REDUCED THE FATIGUE AND DEPRESSIVE SYMPTOM SCORES OF PATIENTS WITH CFS WITHOUT AFFECTING ANY OTHER PARAMETERS WE INVESTIGATED. THIS STUDY FAILED TO IDENTIFY THE MARKERS RESPONSIBLE FOR THE LONGITUDINAL FATIGUE-RELIEVING EFFECT OF SEATED ISOMETRIC YOGA. HOWEVER, CONSIDERING THAT THE REDUCED FATIGUE WAS ASSOCIATED WITH DECREASED SERUM TNF-ALPHA LEVEL AND TAS-20 SCORES, FATIGUE IMPROVEMENT MIGHT BE RELATED TO REDUCED INFLAMMATION AND IMPROVED ALEXITHYMIA IN THESE PATIENTS. TRIAL REGISTRATION: UNIVERSITY HOSPITAL MEDICAL INFORMATION NETWORK (UMIN CTR) UMIN000009646. REGISTERED DEC 27, 2012.	2019	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
3 2328  18 TRUNK AND HIP MUSCLE ACTIVATION DURING YOGA POSES: DO SEX-DIFFERENCES EXIST? OBJECTIVE: TO COMPARE CORE ACTIVATION DURING YOGA BETWEEN MALES AND FEMALES. METHODS: SURFACE ELECTROMYOGRAPHY WAS USED TO QUANTIFY RECTUS ABDOMINIS (RA), ABDOMINAL OBLIQUES (AO), LUMBAR EXTENSORS (LE), AND GLUTEUS MAXIMUS (GMX) ACTIVATION DURING FOUR YOGA POSES. DATA WERE EXPRESSED AS 100% OF A MAXIMUM VOLUNTARY ISOMETRIC CONTRACTION. MIXED-MODEL 2X2 ANALYSES OF VARIANCE WITH REPEATED MEASURES WERE USED TO DETERMINE BETWEEN-SEX DIFFERENCES IN MUSCLE ACTIVITY. RESULTS: FEMALES GENERATED GREATER RA ACTIVITY THAN MALES DURING THE HIGH PLANK (P<0.0001) AND DOMINANT-SIDE WARRIOR 1 (P=0.017). THEY GENERATED GREATER AO (P<0.0001) AND GMX (P=0.004) ACTIVITY DURING THE HIGH PLANK (P<0.0001). NO BETWEEN-SEX EMG ACTIVITY DIFFERENCES EXISTED FOR THE CHAIR AND UPWARD FACING DOG. CONCLUSION: FINDINGS HAVE PROVIDED PRELIMINARY EVIDENCE FOR BETWEEN-SEX DIFFERENCES IN MUSCLE ACTIVATION DURING YOGA POSES. CLINICIANS SHOULD CONSIDER SUCH DIFFERENCES WHEN PRESCRIBING YOGA TO IMPROVE MUSCLE STRENGTH AND ENDURANCE.	2018	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
4  610  61 DEVELOPMENT OF A RECUMBENT ISOMETRIC YOGA PROGRAM FOR PATIENTS WITH SEVERE CHRONIC FATIGUE SYNDROME/MYALGIC ENCEPHALOMYELITIS: A PILOT STUDY TO ASSESS FEASIBILITY AND EFFICACY. BACKGROUND: OUR PREVIOUS RANDOMIZED CONTROLLED TRIAL DEMONSTRATED THAT ISOMETRIC YOGA IN A SITTING POSITION REDUCES FATIGUE IN PATIENTS WITH CHRONIC FATIGUE SYNDROME/MYALGIC ENCEPHALOMYELITIS (CFS/ME). HOWEVER, SOME PATIENTS EXPERIENCE DIFFICULTIES SITTING OR PRACTICING ISOMETRIC YOGA IN A SITTING POSITION FOR LONG PERIODS. TO DATE, THERAPEUTIC INTERVENTIONS FOR PATIENTS WITH SEVERE SYMPTOMS HAVE NOT BEEN ESTABLISHED. THEREFORE, WE DEVELOPED A RECUMBENT ISOMETRIC YOGA PROGRAM, WHICH TAKES APPROXIMATELY 20 MIN TO COMPLETE, DESIGNED TO REDUCE FATIGUE IN PATIENTS WITH SEVERE CFS/ME. THE AIM OF THIS PILOT STUDY WAS TO ASSESS THE FEASIBILITY, SAFETY, AND USEFULNESS OF THIS PROGRAM. METHODS: THIS PILOT STUDY INCLUDED 12 ADULT PATIENTS WITH CFS/ME. SIX PATIENTS WERE RELUCTANT TO PRACTICE ISOMETRIC YOGA IN A SITTING POSITION BECAUSE OF THE SEVERITY OF THEIR FATIGUE (GROUP 1). THE REMAINING SIX PATIENTS HAD PREVIOUSLY PRACTICED ISOMETRIC YOGA IN A SITTING POSITION (GROUP 2). FOR 3 MONTHS, THE PATIENTS OF BOTH GROUPS PRACTICED RECUMBENT ISOMETRIC YOGA EVERY 2 TO 4 WEEKS WITH A YOGA INSTRUCTOR AND AT HOME ON OTHER DAYS IF THEY COULD. THE SHORT-TERM EFFECTS OF ISOMETRIC YOGA ON FATIGUE WERE ASSESSED USING THE PROFILE OF MOOD STATUS (POMS) QUESTIONNAIRE IMMEDIATELY BEFORE AND AFTER THEIR FINAL SESSION WITH THE YOGA INSTRUCTOR. THE LONG-TERM EFFECTS OF ISOMETRIC YOGA ON FATIGUE WERE ASSESSED USING THE CHALDER FATIGUE SCALE (FS) QUESTIONNAIRE BEFORE AND AFTER THE INTERVENTION PERIOD. ADVERSE EVENTS, SATISFACTION WITH THE PROGRAM, AND PREFERENCE OF YOGA POSITION (SITTING OR RECUMBENT) WERE ALSO RECORDED. RESULTS: ALL SUBJECTS COMPLETED THE INTERVENTION. IN BOTH GROUPS, THE POMS FATIGUE SCORE WAS SIGNIFICANTLY DECREASED AFTER PRACTICING THE 20-MIN YOGA PROGRAM AND THE CHALDER FS SCORE WAS DECREASED SIGNIFICANTLY AFTER THE 3-MONTH INTERVENTION PERIOD. THERE WERE NO SERIOUS ADVERSE EVENTS. ALL SUBJECTS IN GROUP 2 PREFERRED THE RECUMBENT ISOMETRIC YOGA PROGRAM OVER A SITTING YOGA PROGRAM. CONCLUSIONS: THIS STUDY SUGGESTS THAT RECUMBENT ISOMETRIC YOGA IS A FEASIBLE AND ACCEPTABLE TREATMENT FOR PATIENTS WITH CFS/ME, EVEN FOR PATIENTS WHO EXPERIENCE DIFFICULTY PRACTICING ISOMETRIC YOGA IN THE SITTING POSITION.	2017	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
5 2329  22 TRUNK AND HIP MUSCLE ACTIVATION DURING YOGA POSES: IMPLICATIONS FOR PHYSICAL THERAPY PRACTICE. OBJECTIVE: TO DETERMINE AND COMPARE ACTIVATION OF CORE MUSCLES DURING YOGA TO TRADITIONAL BACK EXERCISES. METHODS: SURFACE ELECTROMYOGRAPHY WAS USED TO QUANTIFY ACTIVATION OF THE RECTUS ABDOMINIS (RA), ABDOMINAL OBLIQUES (AO), LUMBAR EXTENSORS (LE), AND GLUTEUS MAXIMUS (GMX) DURING FOUR YOGA POSES. DATA WERE EXPRESSED AS 100% OF A MAXIMUM VOLUNTARY ISOMETRIC CONTRACTION. SEPARATE ANALYSES OF VARIANCE WITH REPEATED MEASURES WERE USED TO COMPARE MUSCLE ACTIVITY ACROSS EACH EXERCISE. RESULTS: SUBJECTS GENERATED GREATER RA (P < 0.0001) AND AO (P < 0.0001) ACTIVITY DURING THE PLANK. THEY GENERATED GREATER AO ACTIVITY (P < 0.0001) DURING THE UPWARD-FACING DOG THAN THE CHAIR AND DOMINANT-SIDE WARRIOR 1. LE ACTIVITY WAS GREATEST (P < 0.0001) DURING THE CHAIR. GMX ACTIVITY WAS SIMILAR (P = 0.09) DURING ALL EXERCISES. CONCLUSION: YOGA POSES MAY HELP IMPROVE CORE ENDURANCE AND STRENGTH. CLINICIANS MAY USE THESE DATA WHEN DEVELOPING AND IMPLEMENTING AN EVIDENCE-BASED CORE EXERCISE PROGRAM FOR INDIVIDUALS WHO PREFER A YOGA TREATMENT STRATEGY.	2017	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
6  450  71 CHANGES IN CIRCULATING MICRORNA AFTER RECUMBENT ISOMETRIC YOGA PRACTICE BY PATIENTS WITH MYALGIC ENCEPHALOMYELITIS/CHRONIC FATIGUE SYNDROME: AN EXPLORATIVE PILOT STUDY. BACKGROUND: YOGA IS A REPRESENTATIVE MIND-BODY THERAPY. OUR PREVIOUS STUDIES HAVE DEMONSTRATED THAT ISOMETRIC YOGA (I.E. YOGA PROGRAMS THAT WE DEVELOPED SO INDIVIDUALS CAN PRACTICE YOGA POSES WITH A SELF-ADJUSTABLE ISOMETRIC LOAD) REDUCES THE FATIGUE OF PATIENTS WITH MYALGIC ENCEPHALOMYELITIS/CHRONIC FATIGUE SYNDROME (ME/CFS); HOWEVER, THE UNDERLYING MECHANISMS REMAIN UNCLEAR. SEVERAL STUDIES HAVE SUGGESTED THAT THE MICRO-RIBONUCLEIC ACID (MIRNA) EXPRESSION OF ME/CFS PATIENTS IS DIFFERENT FROM THAT OF HEALTHY SUBJECTS. HOWEVER, IT HAS NOT TO DATE BEEN DETERMINED IF THE PRACTICE OF ISOMETRIC YOGA CAN AFFECT MIRNA EXPRESSION. THEREFORE, WE SOUGHT TO INVESTIGATE IF ISOMETRIC YOGA IS ASSOCIATED WITH CHANGES IN THE EXPRESSION LEVELS OF SERUM MIRNA OF PATIENTS WITH ME/CFS. METHODS: THE STUDY INCLUDED NINE PATIENTS WITH ME/CFS WHO FAILED TO SHOW SATISFACTORY IMPROVEMENT AFTER AT LEAST 6 MONTHS OF TREATMENT ADMINISTERED AT OUR HOSPITAL. PATIENTS PRACTICED RECUMBENT ISOMETRIC YOGA FOR 3 MONTHS; THEY MET WITH A YOGA INSTRUCTOR EVERY 2 TO 4 WEEKS AND PARTICIPATED IN DAILY IN-HOME SESSIONS. THE EFFECT OF RECUMBENT ISOMETRIC YOGA ON FATIGUE WAS ASSESSED BY COMPARING PRE- AND POST-INTERVENTION SCORES ON THE JAPANESE VERSION OF THE 11-ITEM CHALDER FATIGUE SCALE (CFQ 11). PATIENT BLOOD SAMPLES WERE DRAWN PRE- AND POST-INTERVENTION, JUST PRIOR TO PRACTICING RECUMBENT ISOMETRIC YOGA WITH AN INSTRUCTOR. THE SERUM WAS USED FOR MIRNA ARRAY ANALYSIS WITH KNOWN HUMAN MIRNAS. RESULTS: THE AVERAGE CFQ 11 SCORE DECREASED SIGNIFICANTLY (FROM 25.3 +/- 5.5 TO 17.0 +/- 5.8, P < 0.0001) AFTER PRACTICING RECUMBENT ISOMETRIC YOGA FOR 3 MONTHS. THE MIRNA MICROARRAY ANALYSIS REVEALED THAT FOUR MIRNAS WERE SIGNIFICANTLY UPREGULATED, AND 42 WERE DOWNREGULATED AFTER THE INTERVENTION PERIOD. CONCLUSIONS: THIS EXPLORATIVE PILOT STUDY IS THE FIRST TO DEMONSTRATE CHANGES IN THE SERUM LEVELS OF SEVERAL MIRNAS AFTER REGULAR PRACTICE OF RECUMBENT ISOMETRIC YOGA. THESE MIRNAS MIGHT REPRESENT BIOMARKERS FOR THE FATIGUE-RELIEVING EFFECTS OF ISOMETRIC YOGA OF PATIENTS WITH ME/CFS. TRIAL REGISTRATION: UNIVERSITY HOSPITAL MEDICAL INFORMATION NETWORK (UMIN CTR) 000023472. REGISTERED AUG 4, 2016.	2019	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
7 1523  75 ISOMETRIC YOGA IMPROVES THE FATIGUE AND PAIN OF PATIENTS WITH CHRONIC FATIGUE SYNDROME WHO ARE RESISTANT TO CONVENTIONAL THERAPY: A RANDOMIZED, CONTROLLED TRIAL. BACKGROUND: PATIENTS WITH CHRONIC FATIGUE SYNDROME (CFS) OFTEN COMPLAIN OF PERSISTENT FATIGUE EVEN AFTER CONVENTIONAL THERAPIES SUCH AS PHARMACOTHERAPY, COGNITIVE BEHAVIORAL THERAPY, OR GRADED EXERCISE THERAPY. THE AIM OF THIS STUDY WAS TO INVESTIGATE IN A RANDOMIZED, CONTROLLED TRIAL THE FEASIBILITY AND EFFICACY OF ISOMETRIC YOGA IN PATIENTS WITH CFS WHO ARE RESISTANT TO CONVENTIONAL TREATMENTS. METHODS: THIS TRIAL ENROLLED 30 PATIENTS WITH CFS WHO DID NOT HAVE SATISFACTORY IMPROVEMENT AFTER RECEIVING CONVENTIONAL THERAPY FOR AT LEAST SIX MONTHS. THEY WERE RANDOMLY DIVIDED INTO TWO GROUPS AND WERE TREATED WITH EITHER CONVENTIONAL PHARMACOTHERAPY (CONTROL GROUP, N = 15) OR CONVENTIONAL THERAPY TOGETHER WITH ISOMETRIC YOGA PRACTICE THAT CONSISTED OF BIWEEKLY, 20-MINUTE SESSIONS WITH A YOGA INSTRUCTOR AND DAILY IN-HOME SESSIONS (YOGA GROUP, N = 15) FOR APPROXIMATELY TWO MONTHS. THE SHORT-TERM EFFECT OF ISOMETRIC YOGA ON FATIGUE WAS ASSESSED BY ADMINISTRATION OF THE PROFILE OF MOOD STATUS (POMS) QUESTIONNAIRE IMMEDIATELY BEFORE AND AFTER THE FINAL 20-MINUTE SESSION WITH THE INSTRUCTOR. THE LONG-TERM EFFECT OF ISOMETRIC YOGA ON FATIGUE WAS ASSESSED BY ADMINISTRATION OF THE CHALDER'S FATIGUE SCALE (FS) QUESTIONNAIRE TO BOTH GROUPS BEFORE AND AFTER THE INTERVENTION. ADVERSE EVENTS AND CHANGES IN SUBJECTIVE SYMPTOMS WERE RECORDED FOR SUBJECTS IN THE YOGA GROUP. RESULTS: ALL SUBJECTS COMPLETED THE INTERVENTION. THE MEAN POMS FATIGUE SCORE DECREASED SIGNIFICANTLY (FROM 21.9 +/- 7.7 TO 13.8 +/- 6.7, P < 0.001) AFTER A YOGA SESSION. THE CHALDER'S FS SCORE DECREASED SIGNIFICANTLY (FROM 25.9 +/- 6.1 TO 19.2 +/- 7.5, P = 0.002) IN THE YOGA GROUP, BUT NOT IN THE CONTROL GROUP. IN ADDITION TO THE IMPROVEMENT OF FATIGUE, TWO PATIENTS WITH CFS AND FIBROMYALGIA SYNDROME IN THE YOGA GROUP ALSO REPORTED PAIN RELIEF. FURTHERMORE, MANY SUBJECTS REPORTED THAT THEIR BODIES BECAME WARMER AND LIGHTER AFTER PRACTICING ISOMETRIC YOGA. ALTHOUGH THERE WERE NO SERIOUS ADVERSE EVENTS IN THE YOGA GROUP, TWO PATIENTS COMPLAINED OF TIREDNESS AND ONE OF DIZZINESS AFTER THE FIRST YOGA SESSION WITH THE INSTRUCTOR. CONCLUSIONS: ISOMETRIC YOGA AS AN ADD-ON THERAPY IS BOTH FEASIBLE AND SUCCESSFUL AT RELIEVING THE FATIGUE AND PAIN OF A SUBSET OF THERAPY-RESISTANT PATIENTS WITH CFS. TRIAL REGISTRATION: UNIVERSITY HOSPITAL MEDICAL INFORMATION NETWORK (UMIN CTR) UMIN000009646.	2014	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
8  992  24 EFFECTS OF HATHA YOGA PRACTICE ON THE HEALTH-RELATED ASPECTS OF PHYSICAL FITNESS. TEN HEALTHY, UNTRAINED VOLUNTEERS (NINE FEMALES AND ONE MALE), RANGING IN AGE FROM 18-27 YEARS, WERE STUDIED TO DETERMINE THE EFFECTS OF HATHA YOGA PRACTICE ON THE HEALTH-RELATED ASPECTS OF PHYSICAL FITNESS, INCLUDING MUSCULAR STRENGTH AND ENDURANCE, FLEXIBILITY, CARDIORESPIRATORY FITNESS, BODY COMPOSITION, AND PULMONARY FUNCTION. SUBJECTS WERE REQUIRED TO ATTEND A MINIMUM OF TWO YOGA CLASSES PER WEEK FOR A TOTAL OF 8 WEEKS. EACH YOGA SESSION CONSISTED OF 10 MINUTES OF PRANAYAMAS (BREATH-CONTROL EXERCISES), 15 MINUTES OF DYNAMIC WARM-UP EXERCISES, 50 MINUTES OF ASANAS (YOGA POSTURES), AND 10 MINUTES OF SUPINE RELAXATION IN SAVASANA (CORPSE POSE). THE SUBJECTS WERE EVALUATED BEFORE AND AFTER THE 8-WEEK TRAINING PROGRAM. ISOKINETIC MUSCULAR STRENGTH FOR ELBOW EXTENSION, ELBOW FLEXION, AND KNEE EXTENSION INCREASED BY 31%, 19%, AND 28% (P<0.05), RESPECTIVELY, WHEREAS ISOMETRIC MUSCULAR ENDURANCE FOR KNEE FLEXION INCREASED 57% (P<0.01). ANKLE FLEXIBILITY, SHOULDER ELEVATION, TRUNK EXTENSION, AND TRUNK FLEXION INCREASED BY 13% (P<0.01), 155% (P<0.001), 188% (P<0.001), AND 14% (P<0.05), RESPECTIVELY. ABSOLUTE AND RELATIVE MAXIMAL OXYGEN UPTAKE INCREASED BY 7% AND 6%, RESPECTIVELY (P<0.01). THESE FINDINGS INDICATE THAT REGULAR HATHA YOGA PRACTICE CAN ELICIT IMPROVEMENTS IN THE HEALTH-RELATED ASPECTS OF PHYSICAL FITNESS. (C)2001 CHF, INC.	2001	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
9  263  43 ACUTE CARDIOVASCULAR RESPONSES TO A SESSION OF BIKRAM YOGA: A PILOT UNCONTROLLED TRIAL. INTRODUCTION: MAIN CARDIOVASCULAR PARAMETERS SUCH AS HEART RATE (HR), BLOOD PRESSURE, AND MYOCARDIAL OXYGEN CONSUMPTION (MOC) ARE TIGHTLY REGULATED BY A MULTIFACTORIAL, NONLINEAR CONTROL SYSTEM. INCREASED HR BECAUSE OF PHYSICAL ACTIVITY IS OFTEN ACCOMPANIED BY AN INCREASE IN BLOOD PRESSURE. POSTURAL CHANGES HAVE AN EFFECT ON THE BARORECEPTORS, AND STRETCHING EXERCISES AND ISOMETRIC CONTRACTIONS MODULATE MUSCLE MECHANORECEPTORS ELICITING INCREASES IN BLOOD PRESSURE. HOWEVER, A HOT ENVIRONMENT INCREASES THE CORE TEMPERATURE INDUCING VASODILATION AND PLASMA VOLUME CHANGES THAT MIGHT CONTRIBUTE TO A DROP IN BLOOD PRESSURE. DURING THE PRACTICE OF BIKRAM YOGA, ALL THESE FACTORS CONVERGE AND LITTLE IS KNOWN ABOUT THE RESULTING CHANGES IN BLOOD PRESSURE AND MOC. METHODS: SIXTEEN APPARENTLY HEALTHY FEMALE VOLUNTEERS, REGULAR PRACTITIONERS OF BIKRAM YOGA, WERE EVALUATED DURING A 90 MIN SESSION. SYSTOLIC BLOOD PRESSURE (SBP) AND DIASTOLIC BLOOD PRESSURE (DBP) WERE MEASURED IMMEDIATELY AFTER EACH POSTURE AND HR WAS MEASURED CONTINUOUSLY DURING THE PRACTICE. RESULTS: HR AND ESTIMATED MOC INCREASED SIGNIFICANTLY OVER BASELINE DURING THE EXERCISE (+62.3% AND +63.6%, RESPECTIVELY). HR MEAN VALUE ACROSS THE ENTIRE BIKRAM YOGA SESSION WAS 126.6 +/- 14.3 BPM REACHING A MAXIMUM OF 168.1 +/- 20.2 BPM. SBP WAS NOT SIGNIFICANTLY INCREASED OVER BASELINE AT ANY TIME DURING THE PRACTICE WITH A MEAN VALUE OF 117.0 +/- 10.1 MMHG AND DBP WAS SIGNIFICANTLY DECREASED OVER BASELINE MOST OF THE TIME (-10.1%, MEAN 71.2 +/- 7.3 MMHG) WITH PARTICULAR DECLINE TOWARD THE END OF THE PRACTICE DURING THE FLOOR POSTURES. CONCLUSIONS: DBP DURING THE PRACTICE OF BIKRAM YOGA WAS SIGNIFICANTLY DIFFERENT FROM THAT PREVIOUSLY REPORTED FOR NONHEATED HATHA YOGA FOR NORMOTENSIVE SUBJECTS. FURTHER STUDIES EVALUATING THE SAME GROUP AT BOTH CONDITIONS ARE NEEDED TO BETTER CHARACTERIZE THE MAGNITUDE OF THE CHANGES IN HR, SBP, DBP, AND MOC.	2019	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
10 1948  24 SCAPULAR MUSCLE ACTIVITY DURING STATIC YOGA POSTURES. STUDY DESIGN CONTROLLED, CROSS-SECTIONAL LABORATORY STUDY. BACKGROUND DESPITE THE GROWING POPULARITY OF YOGA, LITTLE IS KNOWN ABOUT THE MUSCLE ACTIVITY OF THE SCAPULAR STABILIZERS DURING ISOMETRIC YOGA POSTURES AND THEIR POTENTIAL UTILITY IN SHOULDER REHABILITATION. OBJECTIVES TO EXAMINE SCAPULAR STABILIZER MUSCLE ACTIVATION DURING VARIOUS YOGA POSTURES. METHODS TWENTY WOMEN WITH YOGA EXPERIENCE AND NO SHOULDER PAIN OR INJURY PARTICIPATED. ELECTROMYOGRAPHY WAS USED TO RECORD THE MUSCLE ACTIVITY OF THE UPPER, MIDDLE, AND LOWER TRAPEZIUS, AS WELL AS OF THE SERRATUS ANTERIOR, DURING 15 YOGA POSTURES. RESULTS MUSCLE ACTIVITY VARIED BETWEEN YOGA POSTURES (3%-57% MAXIMUM VOLUNTARY ISOMETRIC CONTRACTION [MVIC]). OVERALL, THE "LOCUST ARMS FORWARD" POSTURE ELICITED THE HIGHEST ACTIVITY FROM THE UPPER (22.4% MVIC), MIDDLE (41.8% MVIC), AND LOWER (56.8% MVIC) TRAPEZIUS, WHILE SEVERAL POSTURES ELICITED MODERATE ACTIVITY (GREATER THAN 20% MVIC) FROM THE SERRATUS ANTERIOR. CONVERSELY, THE "DANCER'S POSE RIGHT," "REVERSE TABLETOP," AND "WARRIOR II" POSTURES DEMONSTRATED LOW ACTIVITY (LESS THAN OR EQUAL TO 15.7% MVIC) OF THE SCAPULAR STABILIZERS. CONCLUSION STRENGTHENING THE SCAPULAR STABILIZER MUSCLES IS AN IMPORTANT COMPONENT OF SHOULDER REHABILITATION. YOGA POSTURES HAVE BEEN IDENTIFIED THAT ACTIVATE THE SCAPULAR STABILIZER MUSCLES AT VARYING LEVELS OF ACTIVITY. J ORTHOP SPORTS PHYS THER 2018;48(6):504-509. EPUB 6 APR 2018. DOI:10.2519/JOSPT.2018.7311.	2018	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
11 1317  41 HEART RATE VARIABILITY CHANGES DURING HIGH FREQUENCY YOGA BREATHING AND BREATH AWARENESS. BACKGROUND: PRE AND POST COMPARISON AFTER ONE MINUTE OF HIGH FREQUENCY YOGA BREATHING (HFYB) SUGGESTED THAT THE HFYB MODIFIES THE AUTONOMIC STATUS BY INCREASING SYMPATHETIC MODULATION, BUT ITS EFFECT DURING THE PRACTICE WAS NOT ASSESSED. METHODS: THIRTY-EIGHT MALE VOLUNTEERS WITH GROUP AVERAGE AGE +/- S.D., 23.3 +/- 4.4 YEARS WERE EACH ASSESSED ON TWO SEPARATE DAYS IN TWO SESSIONS, (I) HFYB AND (II) BREATH AWARENESS. EACH SESSION WAS FOR 35 MINUTES, WITH 3 PERIODS, I.E., PRE (5 MINUTES), DURING HFYB OR BREATH AWARENESS (15 MINUTES) AND POST (5 MINUTES). RESULTS: THERE WAS A SIGNIFICANT DECREASE IN NN50, PNN50 AND THE MEAN RR INTERVAL DURING AND AFTER HFYB AND AFTER BREATH AWARENESS, COMPARED TO THE RESPECTIVE 'PRE' VALUES (P < 0.05) (REPEATED MEASURES ANOVA FOLLOWED BY POST-HOC ANALYSIS). THE LF POWER INCREASED AND HF POWER DECREASED DURING AND AFTER BREATH AWARENESS AND LF/HF RATIO INCREASED AFTER BREATH AWARENESS (P < 0.05). CONCLUSION: THE RESULTS SUGGEST THAT THERE WAS REDUCED PARASYMPATHETIC MODULATION DURING AND AFTER HFYB AND INCREASED SYMPATHETIC MODULATION WITH REDUCED PARASYMPATHETIC MODULATION DURING AND AFTER BREATH AWARENESS.	2011	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
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	2008	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
13  985  42 EFFECTS OF HATHA YOGA AND OMKAR MEDITATION ON CARDIORESPIRATORY PERFORMANCE, PSYCHOLOGIC PROFILE, AND MELATONIN SECRETION. OBJECTIVES: TO EVALUATE EFFECTS OF HATHA YOGA AND OMKAR MEDITATION ON CARDIORESPIRATORY PERFORMANCE, PSYCHOLOGIC PROFILE, AND MELATONIN SECRETION. SUBJECTS AND METHODS: THIRTY HEALTHY MEN IN THE AGE GROUP OF 25-35 YEARS VOLUNTEERED FOR THE STUDY. THEY WERE RANDOMLY DIVIDED IN TWO GROUPS OF 15 EACH. GROUP 1 SUBJECTS SERVED AS CONTROLS AND PERFORMED BODY FLEXIBILITY EXERCISES FOR 40 MINUTES AND SLOW RUNNING FOR 20 MINUTES DURING MORNING HOURS AND PLAYED GAMES FOR 60 MINUTES DURING EVENING HOURS DAILY FOR 3 MONTHS. GROUP 2 SUBJECTS PRACTICED SELECTED YOGIC ASANAS (POSTURES) FOR 45 MINUTES AND PRANAYAMA FOR 15 MINUTES DURING THE MORNING, WHEREAS DURING THE EVENING HOURS THESE SUBJECTS PERFORMED PREPARATORY YOGIC POSTURES FOR 15 MINUTES, PRANAYAMA FOR 15 MINUTES, AND MEDITATION FOR 30 MINUTES DAILY, FOR 3 MONTHS. ORTHOSTATIC TOLERANCE, HEART RATE, BLOOD PRESSURE, RESPIRATORY RATE, DYNAMIC LUNG FUNCTION (SUCH AS FORCED VITAL CAPACITY, FORCED EXPIRATORY VOLUME IN 1 SECOND, FORCED EXPIRATORY VOLUME PERCENTAGE, PEAK EXPIRATORY FLOW RATE, AND MAXIMUM VOLUNTARY VENTILATION), AND PSYCHOLOGIC PROFILE WERE MEASURED BEFORE AND AFTER 3 MONTHS OF YOGIC PRACTICES. SERIAL BLOOD SAMPLES WERE DRAWN AT VARIOUS TIME INTERVALS TO STUDY EFFECTS OF THESE YOGIC PRACTICES AND OMKAR MEDITATION ON MELATONIN LEVELS. RESULTS: YOGIC PRACTICES FOR 3 MONTHS RESULTED IN AN IMPROVEMENT IN CARDIORESPIRATORY PERFORMANCE AND PSYCHOLOGIC PROFILE. THE PLASMA MELATONIN ALSO SHOWED AN INCREASE AFTER THREE MONTHS OF YOGIC PRACTICES. THE SYSTOLIC BLOOD PRESSURE, DIASTOLIC BLOOD PRESSURE, MEAN ARTERIAL PRESSURE, AND ORTHOSTATIC TOLERANCE DID NOT SHOW ANY SIGNIFICANT CORRELATION WITH PLASMA MELATONIN. HOWEVER, THE MAXIMUM NIGHT TIME MELATONIN LEVELS IN YOGA GROUP SHOWED A SIGNIFICANT CORRELATION (R = 0.71, P < 0.05) WITH WELL-BEING SCORE. CONCLUSION: THESE OBSERVATIONS SUGGEST THAT YOGIC PRACTICES CAN BE USED AS PSYCHOPHYSIOLOGIC STIMULI TO INCREASE ENDOGENOUS SECRETION OF MELATONIN, WHICH, IN TURN, MIGHT BE RESPONSIBLE FOR IMPROVED SENSE OF WELL-BEING.	2004	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
14  809  48 EFFECT OF YOGA ON AUTONOMIC FUNCTIONS AND PSYCHOLOGICAL STATUS DURING BOTH PHASES OF MENSTRUAL CYCLE IN YOUNG HEALTHY FEMALES. CONTEXT: PREMENSTRUAL STRESS AFFECTS 75% OF WOMEN OF CHILDBEARING AGE AND YOGA HAS BEEN FOUND TO BE BENEFICIAL IN MANY PSYCHO-SOMATIC DISORDERS. AIMS: TO INVESTIGATE THE EFFECT OF INTEGRATED YOGA ON AUTONOMIC PARAMETERS AND PSYCHOLOGICAL WELL-BEING DURING BOTH PRE AND POST PHASES OF MENSTRUAL CYCLE IN HEALTHY YOUNG FEMALE SUBJECTS. SETTINGS AND DESIGN: PRESENT STUDY IS A RANDOMIZED CONTROL TRIAL AND WAS CONDUCTED IN THE DEPARTMENT OF PHYSIOLOGY, LADY HARDINGE MEDICAL COLLEGE, NEW DELHI, INDIA. MATERIAL AND METHODS: FIFTY APPARENTLY HEALTHY FEMALES IN THE AGE GROUP OF 18-20 YEARS WERE RANDOMIZED INTO TWO GROUPS: GROUP I (N=25) CONSISTED OF SUBJECTS WHO PRACTICED YOGA 35-40 MINUTES PER DAY, SIX TIMES PER WEEK FOR THE DURATION OF THREE MENSTRUAL CYCLES. TRAINING WAS GIVEN BY QUALIFIED YOGA INSTRUCTOR. GROUP II (N=25) SUBJECTS ACTED AS CONTROLS. FOLLOWING PARAMETERS WERE RECORDED AT THE BEGINNING AND AFTER COMPLETION OF THREE MENSTRUAL CYCLES IN ALL THE SUBJECTS: HEIGHT, WEIGHT (BW), RESTING HEART RATE (HR), RESTING SYSTOLIC (SBP) AND DIASTOLIC BLOOD PRESSURE (DBP), PARASYMPATHETIC REACTIVITY TESTS INCLUDING EXPIRATION-INSPIRATION RATIO (E: I RATIO) AND 30:15 RATIO, SYMPATHETIC REACTIVITY TESTS INCLUDING BP CHANGES DUE TO ISOMETRIC HAND GRIP (IHG) EXERCISE, AND COLD PRESSOR TEST (CPT). ASSESSMENT OF PSYCHOLOGICAL STATUS WAS DONE BY ADMINISTERING DIPAS (DEFENSE INSTITUTE OF PHYSIOLOGY AND ALLIED SCIENCES) INVENTORIES OF ANGER SELF REPORT SCALE, TRAIT ANXIETY, SENSE OF WELL-BEING AND DEPRESSION SCALE. STATISTICAL ANALYSIS: INTRA-GROUP COMPARISON OF PHYSIOLOGICAL PARAMETERS WAS DONE BY USING PAIRED 'T' TEST, WHEREAS INTRA-GROUP COMPARISON OF NON-PARAMETERIC DATA SUCH AS SCORES OF ANXIETY, DEPRESSION, ANGER AND SENSE OF WELL-BEING WAS DONE BY WILCOXON SIGNED-RANK TEST. INTER-GROUP COMPARISON OF PARAMETERS WAS DONE BY STUDENTS 'T' TEST FOR PARAMETRIC TESTS AND MANN-WHITNEY 'U' TEST FOR NON-PARAMETERIC TESTS. RESULTS: THERE WAS SIGNIFICANTLY HIGHER BW, RESTING SBP, DBP, SYMPATHETIC ACTIVITY AND BLUNTING OF PARASYMPATHETIC REACTIVITY AND ALSO, SIGNIFICANTLY HIGHER SCORES OF ANGER, DEPRESSION, ANXIETY AND DECREASED SCORE OF WELL-BEING IN PREMENSTRUAL PHASE AS COMPARED TO POSTMENSTRUAL PHASE IN BOTH THE GROUPS IN INITIAL CYCLE. THERE WAS SIGNIFICANTLY HIGHER PERCENTAGE DECREASE IN BW, HR, SBP & DBP IN YOGA GROUP AS COMPARED TO CONTROL GROUP IN BOTH THE PHASES FROM INITIAL TO SECOND AND ONWARDS BETWEEN SECOND AND THIRD MENSTRUAL CYCLE. ALSO, DECREASE IN ANGER, DEPRESSION AND ANXIETY AND INCREASE IN WELL-BEING SCORE WAS SIGNIFICANT IN YOGA GROUP AS COMPARED TO CONTROL GROUP FROM INITIAL TO SECOND AND THIRD CYCLE IN PREMENSTRUAL PHASE WHILE THE CHANGE WAS SIGNIFICANT ONLY IN DEPRESSION SCORE IN POSTMENSTRUAL PHASE. CONCLUSION: OUR STUDY SHOWS THAT THERE WAS SIGNIFICANT ALTERATION OF AUTONOMIC FUNCTIONS AND PSYCHOLOGICAL STATUS IN PREMENSTRUAL PHASE WHEN COMPARED WITH POSTMENSTRUAL PHASE IN YOUNG HEALTHY FEMALES. ALSO, REGULAR PRACTICE OF YOGA HAS BENEFICIAL EFFECTS ON BOTH PHASES OF MENSTRUAL CYCLE BY BRINGING PARASYMPATHODOMINANCE AND PSYCHOLOGICAL WELL-BEING PROBABLY BY BALANCING NEURO-ENDOCRINAL AXIS.	2013	

15  969  43 EFFECTS OF AN 8-MONTH YOGA INTERVENTION ON ARTERIAL COMPLIANCE AND MUSCLE STRENGTH IN PREMENOPAUSAL WOMEN. PREVIOUS STUDIES HAVE INDICATED THAT YOGA EXERCISE HAS A POSITIVE EFFECT ON REDUCING BLOOD PRESSURE AND HEART RATE. HOWEVER, NO RANDOMIZED CONTROLLED STUDIES TO DATE HAVE INVESTIGATED ITS EFFECTS ON ARTERIAL COMPLIANCE. THE PURPOSE OF THIS STUDY WAS TO INVESTIGATE THE EFFECTS OF AN 8-MONTH YOGA INTERVENTION ON ARTERIAL COMPLIANCE AND MUSCLE STRENGTH IN NORMAL PREMENOPAUSAL WOMEN 35-50 YEARS OF AGE. THIRTY-FOUR WOMEN WERE RANDOMLY ASSIGNED EITHER TO A YOGA EXERCISE GROUP (YE, N = 16) OR A CONTROL GROUP (CON, N = 18). PARTICIPANTS IN YE GROUP PERFORMED 60 MINUTES OF AN ASHTANGA YOGA SERIES 2 TIMES/WEEK WITH ONE DAY BETWEEN SESSIONS FOR 8 MONTHS. EACH YOGA SESSION CONSISTED OF 15 MINUTES OF WARM-UP EXERCISES, 35 MINUTES OF ASHTANGA YOGA POSTURES AND 10 MINUTES OF COOL-DOWN WITH RELAXATION; AND THE SESSION INTENSITY WAS PROGRESSIVELY INCREASED DURING THE 8 MONTHS. PARTICIPANTS IN CON WERE ENCOURAGED TO MAINTAIN THEIR NORMAL DAILY LIFESTYLES MONITORED BY THE BONE-SPECIFIC PHYSICAL ACTIVITY QUESTIONNAIRE AT 2 MONTH INTERVALS FOR 8 MONTHS. ARTERIAL COMPLIANCE (PULSE CONTOUR ANALYSIS) AND MUSCLE STRENGTH (1 REPETITION MAXIMUM) WERE ASSESSED AT BASELINE AND AFTER THE INTERVENTION. ARTERIAL COMPLIANCE OF THE LARGE AND SMALL ARTERIES WAS NOT AFFECTED BY THE 8 MONTH YOGA TRAINING (P > 0.05). ALSO, THERE WERE NO SIGNIFICANT (P > 0.05) GROUP, TIME, OR GROUP X TIME INTERACTION EFFECTS FOR CARDIOVASCULAR VARIABLES. YE GROUP SIGNIFICANTLY (P < 0.01) IMPROVED LEG PRESS MUSCLE STRENGTH COMPARED TO CON (11.4% VS. -6.5%). EIGHT MONTHS OF ASHTANGA YOGA TRAINING WAS BENEFICIAL FOR IMPROVING LEG PRESS STRENGTH, BUT NOT ARTERIAL COMPLIANCE IN PREMENOPAUSAL WOMEN. KEY POINTSTHE 8 MONTH YOGA TRAINING DID NOT AFFECT ARTERIAL COMPLIANCE OF THE LARGE AND SMALL ARTERIES.NONE OF THE CARDIOVASCULAR VARIABLES WERE CHANGED BY THE YOGA INTERVENTION.ISOTONIC MUSCLE STRENGTH WAS NOT ALTERED BY THE YOGA INTERVENTION, WITH THE EXCEPTION OF LEG PRESS.	2012	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
16 1147  32 ENERGY EXPENDITURE DURING A VINYASA YOGA SESSION. BACKGROUND: VINYASA YOGA HAS BEEN RECENTLY PROMOTED AS ONE OF THE MOST POPULAR MINDFUL EXERCISES TO IMPROVE OVERALL HEALTH, INCLUDING BODY WEIGHT MANAGEMENT. THE PURPOSE OF THIS STUDY WAS TO DETERMINE THE METABOLIC RESPONSE OF 24 MODERATELY TRAINED INDIVIDUALS DURING A 90-MIN GROUP VINYASA YOGA ROUTINE. METHODS: HEART RATE (HR) TIME COURSE OF 12 MALES AND 12 FEMALES (AGE: 39+/-7.33 YEARS) WAS RECORDED DURING TWO GROUP VINYASA YOGA SESSIONS CONSISTED OF FOUR SECTIONS (WARM-UP, HIGH-INTENSITY SURYA NAMASKAR (HSN), NO SURYA NAMASKAR POSTURES, AND COOL-DOWN). MAXIMAL OXYGEN UPTAKE (VO<INF>2PEAK</INF>) AND MAXIMUM HR HAD BEEN ESTIMATED EARLIER AFTER A MAXIMAL TREADMILL TEST. VO<INF>2</INF> DURING VINYASA YOGA SESSIONS WAS ESTIMATED FROM INDIVIDUAL REGRESSION EQUATIONS USING THE RELATIONSHIP OF VO<INF>2</INF> AND HR VALUES DERIVED FROM VO<INF>2PEAK</INF> TEST, WHILE THE METABOLIC RATE (KCAL/MIN) WAS CALCULATED FROM THE RELATIONSHIP OF HR AND KCAL/MIN. TOTAL SESSION ENERGY CONSUMPTION WAS THE AVERAGE VALUE OF THE TWO YOGA SESSIONS. RESULTS: THE 2 (GENDER) X 4 (SECTIONS) MIXED ANOVA REVEALED NO SIGNIFICANT INTERACTION BETWEEN THE TWO FACTORS (P=0.101) FOR THE MEAN METABOLIC RATE (7.1+/-2.6 KCAL/MIN). MEAN METABOLIC RATE THOUGHT WAS HIGHER (P=0.015) IN MALES COMPARED TO FEMALES AT EACH SECTION. ALSO, SIGNIFICANT DIFFERENCES WERE FOUND AMONG THE FOUR VINYASA YOGA SECTIONS (P<0.001) IN THE RATE OF ENERGY EXPENDITURE, WITH HSN PRESENTING THE HIGHEST MEAN VALUES (P<0.05). CONCLUSIONS: IT SEEMS THAT SYSTEMATIC PARTICIPATION IN VINYASA YOGA MAY EFFECTIVELY IMPROVE CARDIORESPIRATORY FITNESS AND PROMOTE BODY WEIGHT LOSS, AS AN ALTERNATIVE METHOD TO TRADITIONAL AEROBIC EXERCISE.	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
17  705  43 EFFECT OF INTEGRATED APPROACH OF YOGA THERAPY ON AUTONOMIC FUNCTIONS IN PATIENTS WITH TYPE 2 DIABETES. BACKGROUND AND OBJECTIVES: INTEGRATED APPROACH OF YOGA THERAPY (IAYT) HAD SHOWN BENEFICIAL EFFECTS IN THE MANAGEMENT OF TYPE 2 DIABETES MELLITUS (DM). AUTONOMIC DYSFUNCTION IS ONE OF THE MAJOR COMPLICATIONS OF TYPE 2 DM. RESEARCH STUDIES HAVE DEMONSTRATED THAT YOGA CAN MODULATE AUTONOMIC FUNCTIONS. HENCE, THE CURRENT STUDY WAS DESIGNED TO ASSESS THE EFFECT OF IAYT ON AUTONOMIC FUNCTIONS IN TYPE 2 DIABETICS. MATERIALS AND METHODS: 15 PATIENTS OF TYPE 2 DM WITH AGES RANGING FROM 35 TO 60 YEARS WERE RECRUITED FOR THE STUDY. THEY WERE DIAGNOSED WITH TYPE 2 DIABETES FROM 1-YEAR TO 15 YEARS. ASSESSMENTS WERE MADE ON DAY 1 (BEFORE YOGA) AND DAY 7 (AFTER 1-WEEK OF YOGA PRACTICE). HEART RATE VARIABILITY (HRV), BLOOD PRESSURE (BP) RESPONSE TO THE ISOMETRIC HANDGRIP AND HEART RATE RESPONSE TO DEEP BREATHING WERE ASSESSED BEFORE AND AFTER 1-WEEK OF IAYT. RESULTS: THERE WAS A SIGNIFICANT REDUCTION IN FASTING PLASMA GLUCOSE FROM 154.67-130.27 MG/DL (WILCOXON SIGNED RANK TEST, P = 0.029) FOLLOWING 1-WEEK OF IAYT. BP RESPONSE TO ISOMETRIC HAND GRIP IMPROVED SIGNIFICANTLY (WILCOXON SIGNED RANK TEST, P = 0.01). THERE WAS NO STATISTICAL SIGNIFICANT CHANGE IN HRV COMPONENTS AND HEART RATE RESPONSE TO DEEP BREATHING TEST. HOWEVER, THERE WAS A TREND OF INCREASE IN THE LOW FREQUENCY POWER (41.07%), HIGH FREQUENCY POWER (6.29%), TOTAL POWER (5.38%), AND STANDARD DEVIATION OF ALL NN INTERVALS (SDNN) (6.29%). CONCLUSION: THESE FINDINGS SUGGEST THAT, IAYT IMPROVED AUTONOMIC FUNCTIONS IN TYPE 2 DIABETES PATIENTS.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
18  341  42 ARTERIAL BLOOD PRESSURE AND CARDIOVASCULAR RESPONSES TO YOGA PRACTICE. CONTEXT: YOGA IS QUALITATIVELY DIFFERENT FROM ANY OTHER MODE OF PHYSICAL ACTIVITY IN THAT IT CONSISTS OF A UNIQUE COMBINATION OF ISOMETRIC MUSCULAR CONTRACTIONS, STRETCHING EXERCISES, RELAXATION TECHNIQUES, AND BREATHING EXERCISES. IN PARTICULAR, YOGA POSTURES CONSIST OF SYSTEMIC ISOMETRIC CONTRACTIONS THAT ARE KNOWN TO ELICIT MARKED INCREASES IN MEAN BLOOD PRESSURE THAT ARE NOT OBSERVED DURING DYNAMIC EXERCISE. STRETCHING CAN ALSO INDUCE INCREASES IN BLOOD PRESSURE AND SYMPATHETIC NERVE ACTIVITY IN THE MUSCLES. CURRENTLY, NOT MUCH IS KNOWN ABOUT CHANGES IN BLOOD PRESSURE AND OTHER CARDIOVASCULAR RESPONSES TO YOGA PRACTICE. OBJECTIVE: THE STUDY INTENDED TO DETERMINE THE ACUTE EFFECTS OF ONE SESSION OF HATHA YOGA PRACTICE ON BLOOD PRESSURE AND OTHER CARDIOVASCULAR RESPONSES. TO GAIN INSIGHT INTO THE LONG-TERM EFFECTS OF YOGA PRACTICE, BOTH NOVICE (N = 19) AND ADVANCED (N = 18) YOGA PRACTITIONERS WERE STUDIED. DESIGN: THE TWO GROUPS WERE MATCHED FOR AGE, GENDER, BMI, AND BLOOD PRESSURE. SETTING: THE SETTING WAS A RESEARCH LABORATORY AT A UNIVERSITY. PARTICIPANTS: THIRTY-SIX APPARENTLY HEALTHY, NONOBESE, SEDENTARY, OR RECREATIONALLY ACTIVE INDIVIDUALS FROM THE COMMUNITY PARTICIPATED IN THE STUDY. INTERVENTION THE INTERVENTION COMPRISED ONE SESSION OF YOGA PRACTICE, IN WHICH PARTICIPANTS FOLLOWED A CUSTOM MADE INSTRUCTIONAL VIDEO PROVIDING A YOGA ROUTINE THAT CONSISTED OF A SERIES OF 23 HATHA-BASED YOGA POSTURES. OUTCOME MEASURES: PRIOR TO ARRIVING AT THE LABORATORY, EACH PARTICIPANT COMPLETED A RESEARCH HEALTH QUESTIONNAIRE, A TRAINING-STATUS QUESTIONNAIRE, AND A YOGA-EXPERIENCE QUESTIONNAIRE. PRIOR TO THE YOGA PRACTICE, EACH PARTICIPANT'S HEIGHT, BODY FAT PERCENTAGE, TRUNK OR LUMBAR FLEXIBILITY, AND ARTERIAL STIFFNESS AS ASSESSED BY CAROTID FEMORAL PULSE WAVE VELOCITY (CFPWV) WERE MEASURED. FOR EACH POSTURE DURING THE YOGA PRACTICE, THE STUDY CONTINUOUSLY MEASURED SYSTOLIC, MEAN, AND DIASTOLIC BLOOD PRESSURES, HEART RATE, STROKE VOLUME, AND CARDIAC OUTPUT. RESULTS: SYSTOLIC, MEAN, AND DIASTOLIC BLOOD PRESSURES INCREASED SIGNIFICANTLY DURING THE YOGA PRACTICE. THE MAGNITUDE OF THESE INCREASES IN BLOOD PRESSURE WAS GREATEST WITH STANDING POSTURES. HEART RATE AND CARDIAC OUTPUT INCREASED SIGNIFICANTLY DURING YOGA PRACTICE, ESPECIALLY WITH STANDING POSTURES. OVERALL, NO DIFFERENCES EXISTED IN CARDIOVASCULAR RESPONSES BETWEEN THE NOVICE AND ADVANCED PRACTITIONERS THROUGHOUT THE YOGA TESTING SESSION; CFPWV VELOCITY WAS SIGNIFICANTLY AND INVERSELY ASSOCIATED WITH LUMBAR FLEXION BUT NOT WITH SIT-AND-REACH TEST SCORES. CONCLUSIONS: THE RESEARCH TEAM CONCLUDED THAT A VARIETY OF HATHA YOGA POSTURES, ESPECIALLY STANDING POSTURES, EVOKED SIGNIFICANT INCREASES IN BLOOD PRESSURE. THE ELEVATION IN BLOOD PRESSURE DUE TO YOGA PRACTICE WAS ASSOCIATED WITH INCREASES IN CARDIAC OUTPUT AND HEART RATE, WHICH ARE RESPONSES SIMILAR TO THOSE OBSERVED IN ISOMETRIC EXERCISE. THE LACK OF OBVIOUS DIFFERENCES IN BLOOD PRESSURE AND OTHER CARDIOVASCULAR RESPONSES BETWEEN NOVICE AND ADVANCED YOGA PRACTITIONERS SUGGESTS THAT LONG-TERM YOGA PRACTICE DOES NOT ATTENUATE ACUTE YOGA RESPONSES.	2013	
                                                                                             
19 2775  41 YOGA RESPIRATORY TRAINING IMPROVES RESPIRATORY FUNCTION AND CARDIAC SYMPATHOVAGAL BALANCE IN ELDERLY SUBJECTS: A RANDOMISED CONTROLLED TRIAL. OBJECTIVES: SINCE AGEING IS ASSOCIATED WITH A DECLINE IN PULMONARY FUNCTION, HEART RATE VARIABILITY AND SPONTANEOUS BAROREFLEX, AND RECENT STUDIES SUGGEST THAT YOGA RESPIRATORY EXERCISES MAY IMPROVE RESPIRATORY AND CARDIOVASCULAR FUNCTION, WE HYPOTHESISED THAT YOGA RESPIRATORY TRAINING MAY IMPROVE RESPIRATORY FUNCTION AND CARDIAC AUTONOMIC MODULATION IN HEALTHY ELDERLY SUBJECTS. DESIGN: 76 HEALTHY ELDERLY SUBJECTS WERE ENROLLED IN A RANDOMISED CONTROL TRIAL IN BRAZIL AND 29 COMPLETED THE STUDY (AGE 68 +/- 6 YEARS, 34% MALES, BODY MASS INDEX 25 +/- 3 KG/M(2)). SUBJECTS WERE RANDOMISED INTO A 4-MONTH TRAINING PROGRAM (2 CLASSES/WEEK PLUS HOME EXERCISES) OF EITHER STRETCHING (CONTROL, N=14) OR RESPIRATORY EXERCISES (YOGA, N=15). YOGA RESPIRATORY EXERCISES (BHASTRIKA) CONSISTED OF RAPID FORCED EXPIRATIONS FOLLOWED BY INSPIRATION THROUGH THE RIGHT NOSTRIL, INSPIRATORY APNOEA WITH GENERATION OF INTRATHORACIC NEGATIVE PRESSURE, AND EXPIRATION THROUGH THE LEFT NOSTRIL. PULMONARY FUNCTION, MAXIMUM EXPIRATORY AND INSPIRATORY PRESSURES (PE(MAX) AND PI(MAX), RESPECTIVELY), HEART RATE VARIABILITY AND BLOOD PRESSURE VARIABILITY FOR SPONTANEOUS BAROREFLEX DETERMINATION WERE DETERMINED AT BASELINE AND AFTER 4 MONTHS. RESULTS: SUBJECTS IN BOTH GROUPS HAD SIMILAR DEMOGRAPHIC PARAMETERS. PHYSIOLOGICAL VARIABLES DID NOT CHANGE AFTER 4 MONTHS IN THE CONTROL GROUP. HOWEVER, IN THE YOGA GROUP, THERE WERE SIGNIFICANT INCREASES IN PE(MAX) (34%, P<0.0001) AND PI(MAX) (26%, P<0.0001) AND A SIGNIFICANT DECREASE IN THE LOW FREQUENCY COMPONENT (A MARKER OF CARDIAC SYMPATHETIC MODULATION) AND LOW FREQUENCY/HIGH FREQUENCY RATIO (MARKER OF SYMPATHOVAGAL BALANCE) OF HEART RATE VARIABILITY (40%, P<0.001). SPONTANEOUS BAROREFLEX DID NOT CHANGE, AND QUALITY OF LIFE ONLY MARGINALLY INCREASED IN THE YOGA GROUP. CONCLUSION: RESPIRATORY YOGA TRAINING MAY BE BENEFICIAL FOR THE ELDERLY HEALTHY POPULATION BY IMPROVING RESPIRATORY FUNCTION AND SYMPATHOVAGAL BALANCE. TRIAL REGISTRATION CINICALTRIALS.GOV IDENTIFIER: NCT00969345; TRIAL REGISTRY NAME: EFFECTS OF RESPIRATORY YOGA TRAINING (BHASTRIKA) ON HEART RATE VARIABILITY AND BAROREFLEX, AND QUALITY OF LIFE OF HEALTHY ELDERLY SUBJECTS.	2011	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
20 1578  41 MEASUREMENT OF THE EFFECT OF ISHA YOGA ON CARDIAC AUTONOMIC NERVOUS SYSTEM USING SHORT-TERM HEART RATE VARIABILITY. BACKGROUND: BENEFICIAL EFFECTS OF YOGA HAVE BEEN POSTULATED TO BE DUE TO MODULATION OF THE AUTONOMIC NERVOUS SYSTEM. OBJECTIVE: TO ASSESS THE EFFECT OF ISHA YOGA PRACTICES ON CARDIOVASCULAR AUTONOMIC NERVOUS SYSTEM THROUGH SHORT-TERM HEART RATE VARIABILITY (HRV). DESIGN OF THE STUDY: SHORT-TERM HRV OF LONG-TERM REGULAR HEALTHY 14 (12 MALES AND 2 FEMALES) ISHA YOGA PRACTITIONERS WAS COMPARED WITH THAT OF AGE- AND GENDER-MATCHED 14 (12 MALES AND 2 FEMALES) NON-YOGA PRACTITIONERS. METHODS AND MATERIALS: ECG LEAD II AND RESPIRATORY MOVEMENTS WERE RECORDED IN BOTH GROUPS USING POLYRITE DURING SUPINE REST FOR 5 MIN AND CONTROLLED DEEP BREATHING FOR 1 MINUTE. FREQUENCY DOMAIN ANALYSIS [RR INTERVAL IS THE MEAN OF DISTANCE BETWEEN SUBSEQUENT R WAVE PEAKS IN ECG], LOW FREQUENCY (LF) POWER, HIGH FREQUENCY (HF) POWER, LF NORMALIZED UNITS (NU), HF NU, LF/HF RATIO] AND TIME DOMAIN ANALYSIS [STANDARD DEVIATION OF NORMAL TO NORMAL INTERVAL (SDNN), SQUARE OF MEAN SQUARED DIFFERENCE OF SUCCESSIVE NORMAL TO NORMAL INTERVALS (RMSSD), NORMAL TO NORMAL INTERVALS WHICH ARE DIFFERING BY 50 MS (NN50), AND PERCENTAGE OF NN50 (PNN50)] OF HRV VARIABLES WERE ANALYZED FOR SUPINE REST. TIME DOMAIN ANALYSIS WAS RECORDED FOR DEEP BREATHING. RESULTS: RESULTS SHOWED STATISTICALLY SIGNIFICANT DIFFERENCES BETWEEN ISHA YOGA PRACTITIONERS AND CONTROLS IN BOTH FREQUENCY AND TIME DOMAIN ANALYSES OF HRV INDICES, WITH NO DIFFERENCE IN RESTING HEART RATE BETWEEN THE GROUPS. CONCLUSIONS: PRACTITIONERS OF ISHA YOGA SHOWED WELL-BALANCED BENEFICIAL ACTIVITY OF VAGAL EFFERENTS, AN OVERALL INCREASED HRV, AND SYMPATHOVAGAL BALANCE, COMPARED TO NON-YOGA PRACTITIONERS DURING SUPINE REST AND DEEP BREATHING.	2012