1 649 226 DYNAMIC EVALUATION OF THE CONTRACTILE FUNCTION OF LUMBODORSAL MUSCLES DURING LOCUST POSE IN YOGA BY REAL-TIME ULTRASOUND. BACKGROUND AND PURPOSE: CHRONIC LOW BACK PAIN (CLBP), WHICH HAS A CLOSE RELATIONSHIP WITH LUMBAR MUSCLE DEGENERATION, CAN BE EFFECTIVELY TREATED BY EXERCISE THERAPY, AND YOGA HAS BEEN WIDELY ACCEPTED BY CLINICIANS AND PATIENTS WITH CLBP. THE PURPOSE OF THIS STUDY WAS TO OBSERVE THE CHANGES IN THE THICKNESS OF LUMBODORSAL MUSCLES THAT OCCUR DURING LOCUST POSE IN YOGA AND HOW THESE CHANGES OCCUR. FROM THE CHANGES IN MUSCLE THICKNESS THAT OCCUR IN THE LOCUST POSE, THE CONTRACTILE FUNCTION OF LUMBODORSAL MUSCLES CAN BE EVALUATED. METHODS: FIFTY-TWO HEALTHY VOLUNTEERS (FROM MAY 2019 TO AUGUST 2019, AGE FROM 28 TO 68 YEARS, 23 MALES AND 29 FEMALES (AGE: 40 +/- 8 YEARS; WEIGHT: 68.3 +/- 5.2 KG; HEIGHT: 170.2 +/- 13.1 CM) WERE RECRUITED, AND LUMBODORSAL MUSCLE, INCLUDING THE MULTIFIDUS, LONGISSIMUS, ILIOCOSTALIS, AND QUADRATUS LUMBORUM, ULTRASONIC EXAMINATIONS WERE CARRIED OUT IN THE RELAXED AND CONTRACTED STATES. THE CHANGES IN THE THICKNESS OF THE LUMBODORSAL MUSCLES IN THE RELAXED AND CONTRACTED STATES WERE DYNAMICALLY OBSERVED BY REAL-TIME ULTRASOUND WHEN SUBJECTS WERE PERFORMING THE LOCUST YOGA POSE. THEN, THE THICKNESSES OF THE MUSCLES DURING THE TWO STATES WERE MEASURED TO CALCULATE THE RATIO OF CONTRACTION OF EACH MUSCLE AND DETERMINE THE STATISTICAL SIGNIFICANCE OF THE CHANGE IN THICKNESS OF EACH MUSCLE. RESULTS: THE MEAN THICKNESS OF THE LEFT MULTIFIDUS IN THE RELAXED STATE WAS 1.32 +/- 0.27 CM (95 % CI: 1.24 ~ 1.39), THAT IN THE CONTRACTED STATE WAS 1.60 +/- 0.30 CM (95 % CI: 1.52 ~ 1.69) (OBVIOUSLY DIFFERENT BETWEEN THE RELAXED AND CONTRACTED STATES, P < 0.001), AND THOSE IN THE CORRESPONDING RIGHT SIDE WERE 1.37 +/- 0.31 CM (95 % CI: 1.29 ~ 2.46) AND 1.68 +/- 0.38 CM (95 % CI: 1.58 ~ 1.79) (P < 0.001), RESPECTIVELY. THE MEAN THICKNESS OF THE LEFT QUADRATUS LUMBORUM IN THE RELAXED STATE WAS 1.38 +/- 0.32 CM (95 % CI: 1.29 ~ 1.47), THAT IN THE CONTRACTED STATE WAS 1.62 +/- 0.40 CM (95 % CI: 1.50 ~ 1.73) (P = 0.001), AND THOSE IN THE CORRESPONDING RIGHT SIDE WERE 1.30 +/- 0.32 CM (95 % CI: 1.21 ~ 1.39) AND 1.55 +/- 0.41 CM (95 % CI: 1.44 ~ 1.67) (P = 0.001), RESPECTIVELY. THE MEAN THICKNESS OF THE LEFT LONGISSIMUS IN THE RELAXED WAS 2.33 +/- 0.51 CM (95 % CI: 2.19 ~ 2.47), THAT IN THE CONTRACTED STATE WAS 3.20 +/- 0.61 CM (95 % CI: 3.03 ~ 3.37) (P < 0.001), AND THOSE IN THE CORRESPONDING RIGHT SIDE WERE 2.34 +/- 0.49 CM (95 % CI 2.20 ~ 2.48) AND 3.26 +/- 0.68 CM (95 % CI 3.07 ~ 3.45) (P < 0.001), RESPECTIVELY. THE MEAN THICKNESS OF THE LEFT ILIOCOSTALIS IN THE RELAXED STATE WAS 1.88 +/- 0.41 CM (95 % CI: 1.76 ~ 1.99), THAT IN THE CONTRACTED STATE WAS 2.34 +/- 0.49 CM (95 % CI: 2.00 ~ 2.47) (P < 0.001), AND THOSE IN THE CORRESPONDING RIGHT SIDE WERE 1.98 +/- 0.40 CM (95 % CI: 1.87 ~ 2.09) AND 2.44 +/- 0.56 CM (95 % CI: 2.29 ~ 2.60) (P < 0.001), RESPECTIVELY. THE MEAN CONTRACTED STATE/RESTING STATE (C/R) OF THE LONGISSIMUS WAS 1.39 +/- 0.14 ON THE LEFT AND 1.40 +/- 0.16 ON THE RIGHT. THE MULTIFIDUS AND ILIOCOSTALIS HAD THE SECOND HIGHEST C/R. THE MEAN C/R OF THE MULTIFIDUS WAS 1.23 +/- 0.12 ON THE LEFT AND 1.24 +/- 0.15 ON THE RIGHT, AND THE MEAN C/R OF THE ILIOCOSTALIS WAS 1.25 +/- 0.12 ON THE LEFT AND 1.24 +/- 0.14 ON THE RIGHT. THE QUADRATUS LUMBORUM HAD THE LOWEST C/R, AND THE MEAN C/R OF THE QUADRATUS LUMBORUM WAS 1.17 +/- 0.10 ON THE LEFT AND 1.19 +/- 0.11 ON THE RIGHT. CONCLUSIONS: ULTRASOUND CAN BE USED TO DYNAMICALLY ASSESS THE CONTRACTILE FUNCTION OF THE LUMBAR MUSCLE IN THE LOCUST POSE OF YOGA, THE C/R RATIO CAN BE USED TO INDICATE THE ABILITY OF A MUSCLE TO CONTRACT, AND DYNAMIC ULTRASOUND CAN GUIDE LUMBAR EXERCISE AND FEEDBACK THE EXERCISE RESULTS. THE ESTABLISHMENT OF THIS MODEL ALLOWED DATA REGARDING THE CONTRACTION STATE OF THE LUMBAR MUSCLE TO BE OBTAINED IN A NORMAL POPULATION, AND BASED ON THIS, FUTURE STUDIES CAN FURTHER EXPLORE AND EVALUATE THE CONTRACTION STATE OF THE LUMBAR MUSCLE AFTER YOGA EXERCISE IN CLBP PATIENTS, THE EFFECT EXERCISE ON LUMBAR INSTABILITY AND ON A PATIENT POPULATION AFTER LUMBAR OPERATION. 2021 2 1690 37 OXIDATIVE STRESS INDUCED DAMAGE TO PATERNAL GENOME AND IMPACT OF MEDITATION AND YOGA - CAN IT REDUCE INCIDENCE OF CHILDHOOD CANCER? BACKGROUND: SPERM DNA DAMAGE IS UNDERLYING AETIOLOGY OF POOR IMPLANTATION AND PREGNANCY RATES BUT ALSO AFFECTS HEALTH OF OFFSPRING AND MAY ALSO RESULT IN DENOVO MUTATIONS IN GERM LINE AND POST FERTILIZATION. THIS MAY RESULT IN COMPLEX DISEASES, POLYGENIC DISORDERS AND CHILDHOOD CANCERS. CHILDHOOD CANCER LIKE RETINOBLASTOMA (RB) IS MORE PREVALENT IN DEVELOPING COUNTRIES AND THE INCIDENCE OF RB HAS INCREASED MORE THAN THREE FOLD IN INDIA IN THE LAST DECADE. RECENT STUDIES HAVE DOCUMENTED INCREASED INCIDENCE OF CANCERS IN CHILDREN BORN TO FATHERS WHO CONSUME ALCOHOL IN EXCESS AND TOBACCO OR WHO WERE CONCEIVED BY ASSISTED CONCEPTION. THE AETIOLOGY OF CHILDHOOD CANCER AND INCREASED DISEASE BURDEN IN THESE CHILDREN IS LIN KED TO OXIDATIVE STRESS (OS) AND OXIDATIVE DNA DAMAGE( ODD) IN SPERM OF THEIR FATHERS. THOUGH SEVERAL ANTIOXIDANTS ARE IN USE TO COMBAT OXIDATIVE STRESS, THE EFFECT OF MAJORITY OF THESE FORMULATIONS ON DNA IS NOT KNOWN. YOGA AND MEDITATION CAUSE SIGNIFICANT DECLINE IN OS AND ODD AND AID IN REGULATING OS LEVELS SUCH THAT REACTIVE OXYGEN SPEUES MEDITATED SIGNAL TRANSDUCTION, GENE EXPRESSION AND SEVERAL OTHER PHYSIOLOGICAL FUNCTIONS ARE NOT DISRUPTED. THUS, THIS STUDY AIMED TO ANALYZE SPERM ODD AS A POSSIBLE ETIOLOGICAL FACTOR IN CHILDHOOD CANCER AND ROLE OF SIMPLE LIFE STYLE INTERVENTIONS LIKE YOGA AND MEDITATION IN SIGNIFICANTLY DECREASING SEMINAL OXIDATIVE STRESS AND OXIDATIVE DNA DAMAGE AND THEREBY DECREASING INCIDENCE OF CHILDHOOD CANCERS. MATERIALS AND METHODS: A TOTAL OF 131 FATHERS OF CHILDREN WITH RB (NON-FAMILIAL SPORADIC HERITABLE) AND 50 CONTROLS (FATHERS OF HEALTHY CHILDREN) WERE RECRUITED AT A TERTIARY CENTER IN INDIA. SPERM PARAMETERS AS PER WHO 2010 GUIDELINES AND REACTIVE OXYGEN SPECIES (ROS), DNA FRAGMENTATION INDEX (DFI), 8-HYDROXY-2'-DEOXY GUANOSINE (8-OHDG) AND TELOMERE LENGTH WERE ESTIMATED AT DAY 0, AND AFTER 3 AND 6 MONTHS OF INTERVENTION. WE ALSO EXAMINED THE COMPLIANCE WITH YOGA AND MEDITATION PRACTICE AND SMOKING STATUS AT EACH FOLLOW-UP. RESULTS: THE SEMINAL MEAN ROS LEVELS (P<0.05), SPERM DFI (P<0.001), 8-OHDG (P<0.01) LEVELS WERE SIGNIFICANTLY HIGHER IN FATHERS OF CHILDREN WITH RB, AS COMPARED TO CONTROLS AND THE RELATIVE MEAN TELOMERE LENGTH IN THE SPERM WAS SHORTER. LEVELS OF ROS WERE SIGNIFICANTLY REDUCED IN TOBACCO USERS (P<0.05) AS WELL AS IN ALCOHOLICS (P<0.05) AFTER INTERVENTION. DFI REDUCED SIGNIFICANTLY (P<0.05) AFTER 6 MONTHS OF YOGA AND MEDITATION PRACTICE IN ALL GROUPS. THE LEVELS OF OXIDATIVE DNA DAMAGE MARKER 8-OHDG WERE REDUCED SIGNIFICANTLY AFTER 3 MONTHS (P<0.05) AND 6 MONTHS (P<0.05) OF PRACTICE. CONCLUSIONS: OUR RESULTS SUGGEST THAT OS AND ODD DNA MAY CONTRIBUTE TO THE DEVELOPMENT OF CHILDHOOD CANCER. THIS MAY BE DUE TO ACCUMULATION OF OXIDIZED MUTAGENIC BASE 8OHDG , AND ELEVATED MDA LEVELS WHICH RESULTS IN MDA DIMERS WHICH ARE ALSO MUTAGENIC, ABERRANT METHYLATION PATTERN, ALTERED GENE EXPRESSION WHICH AFFECT CELL PROLIFERATION AND SURVIVAL THROUGH ACTIVATION OF TRANSCRIPTION FACTORS. INCREASED MT DNA MUTATIONS AND ABERRANT REPAIR OF MT AND NUCLEAR DNA DUE TO HIGHLY TRUNCATRED DNA REPAIR MECHANISMS ALL CONTRIBUTE TO SPERM GENOME HYPERMUTABILITY AND PERSISTANT OXIDATIVE DNA DAMAGE. OXIDATIVE STRESS IS ALSO ASSOCIATED WITH GENOME WIDE HYPOMETHYLATION, TELOMERE SHORTENING AND MITOCHONDRIAL DYSFUNCTION LEADING TO GENOME HYPERMUTABILITY AND INSTABILITY. TO THE BEST OF OUR KNOWLEDGE, THIS IS THE FIRST STUDY TO REPORT DECLINE IN OS AND ODD AND IMPROVEMENT IN SPERM DNA INTEGRITY FOLLOWING ADOPTION OF MEDITATION AND YOGA BASED LIFE STYLE MODIFICATION.THIS MAY REDUCE DISEASE BURDEN IN NEXT GENERATION AND REDUCE INCIDENCE OF CHILDHOOD CANCERS. 2016 3 1991 30 SPINE FUSIONS, YOGA INSTRUCTORS, AND HIP FRACTURES: THE ROLE OF DUAL MOBILITY IN PRIMARY TOTAL HIP ARTHROPLASTY. BACKGROUND: DESPITE THE INCREASED USE OF DUAL MOBILITY (DM) IN PRIMARY TOTAL HIP ARTHROPLASTY (THA), DEBATE EXISTS REGARDING THE INDICATIONS FOR ITS USE. NO SPECIFIC ALGORITHM EXISTS TO GUIDE THIS DECISION-MAKING PROCESS. THEREFORE, THE PURPOSE OF THIS ARTICLE IS TO SUMMARIZE THE CURRENTLY AVAILABLE LITERATURE REGARDING THE USE OF DM IN PRIMARY THA AND PROVIDE EVIDENCE-BASED GUIDELINES BASED ON SPECIFIC PATIENT POPULATIONS AND RISK FACTORS FOR INSTABILITY. METHODS: WE REVIEWED THE CURRENT LITERATURE FOR STUDIES EVALUATING RISK FACTORS FOR DISLOCATION IN PRIMARY THA, AS WELL AS THE CLINICAL USE AND RESULTS OF DM IN PRIMARY THA. BASED ON THE STRENGTH OF THE LITERATURE, WE DISCUSS THE USE OF DM IN SPECIFIC PATIENT POPULATIONS. WE PROVIDE A DECISION-MAKING ALGORITHM TO DETERMINE WHETHER A PATIENT MAY BE INDICATED FOR DM IN PRIMARY THA. RESULTS: SURGEONS SHOULD CONSIDER PREOPERATIVE PATIENT DEMOGRAPHICS, RISK FACTORS FOR INSTABILITY (EG, SIGNIFICANT HIP-SPINE ISSUES), TYPE OF PROCEDURE TO BE PERFORMED (EG, CONVERSION ARTHROPLASTY), AND INDICATIONS FOR SURGERY (EG, THA FOR FEMORAL NECK FRACTURE). BASED ON THIS ALGORITHMIC ASSESSMENT, DM MAY BE WARRANTED IN THE PRIMARY THA SETTING IF A PATIENT'S COMBINED RISK REACHES AN ESTABLISHED THRESHOLD BASED ON THE LITERATURE. CONCLUSION: THIS EVIDENCE-BASED ALGORITHM MAY HELP GUIDE CURRENT PRACTICE IN THE USE OF DM IN PRIMARY THA. WE ADVOCATE THE CONTINUED JUDICIOUS USE OF DM IN HIP ARTHROPLASTY. LONGER TERM STUDIES ARE NEEDED IN ORDER TO EVALUATE THE DURABILITY OF DM, AS WELL AS ANY COMPLICATIONS RELATED TO THE DM ARTICULATION. 2021 4 539 23 COMPLEMENTARY THERAPIES IN PARKINSON DISEASE: A REVIEW OF ACUPUNCTURE, TAI CHI, QI GONG, YOGA, AND CANNABIS. PARKINSON DISEASE (PD) IS A PROGRESSIVE NEURODEGENERATIVE CONDITION CHARACTERIZED BY BRADYKINESIA, RIGIDITY, RESTING TREMOR, AND POSTURAL INSTABILITY. NON-MOTOR SYMPTOMS, INCLUDING PAIN, FATIGUE, INSOMNIA, ANXIETY, AND DEPRESSION TO NAME A FEW, ARE INCREASINGLY RECOGNIZED AND OFTEN JUST AS DISABLING AT MOTOR SYMPTOMS. THE MAINSTAY OF TREATMENT IS DOPAMINE REPLACEMENT; HOWEVER, THE BENEFICIAL EFFECTS TEND TO WANE OVER TIME WITH DISEASE PROGRESSION, AND PATIENTS OFTEN EXPERIENCE MOTOR FLUCTUATIONS AND MEDICATION SIDE EFFECTS. THE LACK OF A DISEASE-MODIFYING INTERVENTION AND THE SHORTCOMINGS OF TRADITIONAL SYMPTOMATIC MEDICATIONS HAVE LED MANY PATIENTS TO PURSUE COMPLEMENTARY THERAPIES TO ALLEVIATE MOTOR AND NON-MOTOR SYMPTOMS ASSOCIATED WITH PD. THE TERM COMPLEMENTARY IMPLIES THAT THE THERAPY IS USED ALONG WITH CONVENTIONAL MEDICINE AND MAY INCLUDE SUPPLEMENTS, MANIPULATIVE TREATMENTS (CHIROPRACTIC, MASSAGE), EXERCISE-BASED PROGRAMS, AND MIND-BODY PRACTICES. AS THESE PRACTICES BECOME MORE WIDESPREAD IN WESTERN MEDICINE, THERE IS A GROWING INTEREST IN EVALUATING THEIR EFFECTS ON A NUMBER OF MEDICAL CONDITIONS, PD INCLUDED. IN THIS REVIEW, WE PROVIDE AN UPDATE ON CLINICAL TRIALS THAT HAVE EVALUATED THE EFFECTIVENESS OF COMPLEMENTARY TREATMENTS FOR PATIENTS WITH PD, SPECIFICALLY FOCUSING ON ACUPUNCTURE, TAI CHI, QI GONG, YOGA, AND CANNABIS. 2020 5 2650 28 YOGA IMPROVES BALANCE AND LOW-BACK PAIN, BUT NOT ANXIETY, IN PEOPLE WITH PARKINSON'S DISEASE. INDIVIDUALS WITH PARKINSON'S DISEASE (PD) EXPERIENCE POSTURAL INSTABILITY, LOW-BACK PAIN (LBP), AND ANXIETY. THESE SYMPTOMS INCREASE THE RISK OF FALLS AND DECREASE QUALITY OF LIFE. RESEARCH SHOWS YOGA IMPROVES BALANCE AND DECREASES LBP AND ANXIETY IN HEALTHY ADULTS, BUT ITS EFFECTS IN PD ARE POORLY UNDERSTOOD. ALL PARTICIPANTS WERE PART OF A LARGER INTERVENTION STUDY. PARTICIPANTS RECEIVED PRETEST AND POSTTEST EVALUATIONS, INCLUDING THE BALANCE EVALUATION SYSTEMS TEST (BESTEST), BECK ANXIETY INVENTORY (BAI), AND REVISED OSWESTRY DISABILITY INDEX (ROSW). TOTAL SCORES FOR EACH MEASURE, AS WELL AS INDIVIDUAL BALANCE SYSTEM SECTION SCORES FROM THE BESTEST (BIOMECHANICAL CONSTRAINTS, STABILITY LIMITS/VERTICALITY, TRANSITIONS/ANTICIPATORY, REACTIVE, SENSORY ORIENTATION, AND STABILITY IN GAIT) WERE COMPARED WITHIN GROUPS PRE- TO POSTTEST. PARTICIPANTS IN THE YOGA GROUP (N = 13) COMPLETED A TWICE-WEEKLY 12-WEEK YOGA INTERVE N T I O N , WHEREAS CONTROLS (N = 13) CONTINUED THEIR USUAL ROUTINES FOR 12 WEEKS. BOTH THE YOGA (Z = -3.20, P = 0.001) AND CONTROL (Z = -2.10, P = 0.040) GROUPS IMPROVED ON THE BESTEST TOTAL SCORE. THE CONTROL GROUP SHOWED NO CHANGES IN INDIVIDUAL BALANCE SYSTEMS, WHEREAS THE YOGA GROUP IMPROVED IN STABILITY LIMITS/VERTICALITY (Z = -2.3, P = 0.020), TRANSITIONS/ ANTICIPATORY (Z = -2.50, P = 0.010), REACTIVE (Z = -2.70, P = 0.008), AND SENSORY ORIENTATION (Z = -2.30, P = 0.020). ROSW DECREASED IN THE YOGA GROUP ONLY (Z = -2.10, P = 0.030). BAI DID NOT CHANGE IN EITHER GROUP. YOGA IS A NONPHARMACOLOGICAL INTERVENTION THAT CAN IMPROVE BALANCE AND LBP IN PEOPLE WITH PD. THIS STUDY DEMONSTRATED THAT YOGA IS FEASIBLE FOR PEOPLE WITH PD, AND PARTICIPANTS REPORTED HIGH LEVELS OF ENJOYMENT AND INTENT TO PRACTICE YOGA AFTER THE STUDY. 2020 6 2652 34 YOGA IMPROVES MITOCHONDRIAL HEALTH AND REDUCES SEVERITY OF AUTOIMMUNE INFLAMMATORY ARTHRITIS: A RANDOMIZED CONTROLLED TRIAL. BACKGROUND: OXIDATIVE STRESS (OS) AND MITOCHONDRIAL ALTERATIONS HAVE BEEN IMPLICATED IN THE PATHOGENESIS OF RHEUMATOID ARTHRITIS (RA). VARIOUS ENVIRONMENTAL TRIGGERS LIKE AIR POLLUTANTS, SMOKING, UNHEALTHY SOCIAL HABITS AND SEDENTARY LIFESTYLE INDUCE OS, WHICH MAY COMPROMISE MITOCHONDRIAL INTEGRITY. THIS TRIAL WAS DESIGNED TO EXPLORE THE EFFECT OF 8-WEEKS YOGA PRACTICE ON MITOCHONDRIAL HEALTH AND DISEASE SEVERITY IN AN ACTIVE RA GROUP COMPARED WITH A USUAL-CARE CONTROL GROUP. METHODS: A TOTAL OF 70 SUBJECTS WERE RANDOMIZED INTO TWO GROUPS: YOGA GROUP AND NON-YOGA GROUP. MITOCHONDRIAL HEALTH WAS ASSESSED BY CALCULATION OF MITOCHONDRIAL DNA COPY NUMBER (MTDNA-CN), OS MARKERS, MITOCHONDRIAL ACTIVITY, MITOCHONDRIAL MEMBRANE POTENTIAL (DELTAPSIM), CIRCADIAN RHYTHM MARKERS AND TRANSCRIPTS ASSOCIATED WITH MITOCHONDRIAL INTEGRITY: AMPK, TIMP-1, KLOTHO, SIRT-1, AND TFAM. PARAMETERS OF DISEASE ACTIVITY AND DISABILITY QUOTIENT WERE ALSO ASSESSED BY DISEASE ACTIVITY SCORE - ERYTHROCYTE SEDIMENTATION RATE (DAS28-ESR) AND HEALTH ASSESSMENT QUESTIONNAIRE-DISABILITY INDEX (HAQ-DI), RESPECTIVELY. RESULTS: IN YOGA GROUP, THERE WAS A SIGNIFICANT UPREGULATION OF MTDNA-CN, MITOCHONDRIAL ACTIVITY MARKERS, DELTAPSIM, AND TRANSCRIPTS THAT MAINTAIN MITOCHONDRIAL INTEGRITY AFTER 8-WEEKS OF YOGA. THERE WAS OPTIMIZATION OF OS MARKERS, AND CIRCADIAN RHYTHM MARKERS POST 8-WEEKS PRACTICE OF YOGA. YOGA GROUP PARTICIPANTS SHOWED SIGNIFICANT IMPROVEMENTS IN DAS28-ESR (P < 0.05) AND HAQ-DI (P < 0.05) OVER THE NON-YOGA GROUP. CONCLUSION: ADOPTION OF YOGA BY RA PATIENTS HOLDS THE KEY TO ENHANCE MITOCHONDRIAL HEALTH, IMPROVE CIRCADIAN RHYTHM MARKERS, OS MARKER REGULATION, UPREGULATION OF TRANSCRIPTS THAT MAINTAIN MITOCHONDRIAL INTEGRITY, REDUCE DISEASE ACTIVITY AND ITS ASSOCIATED CONSEQUENCES ON HEALTH OUTCOME AND HENCE CAN BE BENEFICIAL AS AN ADJUNCT THERAPY. 2021 7 1099 36 EFFECTS OF YOGA THERAPY ON POSTURAL STABILITY IN PATIENTS WITH SCHIZOPHRENIA-SPECTRUM DISORDERS: A SINGLE-BLIND RANDOMIZED CONTROLLED TRIAL. INTRODUCTION: POSTURAL INSTABILITY IS A SERIOUS CONCERN IN PATIENTS WITH SCHIZOPHRENIA-SPECTRUM DISORDERS SINCE IT IS EXPECTED TO INCREASE THE RISK OF FALLS THAT MAY LEAD TO FRACTURES. THE IMPACT OF YOGA THERAPY ON POSTURAL STABILITY HAS NOT BEEN INVESTIGATED. METHODS: IN THIS EIGHT-WEEK SINGLE-BLIND RANDOMIZED CONTROLLED STUDY WITH AN EIGHT-WEEK FOLLOW-UP, OUTPATIENTS WITH SCHIZOPHRENIA OR RELATED PSYCHOTIC DISORDER (ICD-10) WERE RANDOMLY ASSIGNED TO EITHER YOGA THERAPY OR A CONTROL GROUP. IN THE YOGA THERAPY GROUP, THE SUBJECTS RECEIVED WEEKLY SESSIONS OF 60-MIN YOGA THERAPY FOR EIGHT WEEKS IN ADDITION TO THEIR ONGOING TREATMENT. IN THE CONTROL GROUP, THE SUBJECTS RECEIVED A WEEKLY REGULAR DAY-CARE PROGRAM. THE ASSESSMENTS THAT WERE PERFORMED AT THE BASELINE AND ENDPOINT INCLUDED THE CLINICAL STABILOMETRIC PLATFORM (CSP), ANTEFLEXION IN STANDING. RESULTS: FORTY-NINE PATIENTS PARTICIPATED IN THIS STUDY (32 MEN; MEAN +/- SD AGE, 53.1 +/- 12.3 YEARS): YOGA THERAPY GROUP (N = 25) AND CONTROL GROUP (N = 24). IN THE YOGA GROUP, SIGNIFICANT IMPROVEMENTS WERE OBSERVED IN A TOTAL LENGTH OF TRUNK MOTION, THE ROMBERG RATIO, AND ANTEFLEXION IN STANDING AT WEEK 8 (MEAN +/- SD: 63.9 +/- 40.7-53.4 +/- 26.2 CM, 1.6 +/- 0.9-1.1 +/- 0.6, AND -8.7 +/- 9.5 TO -3.8 +/- 12.4 CM, RESPECTIVELY) WHILE THERE WERE NO SIGNIFICANT CHANGES IN THE CONTROL GROUP. HOWEVER, THOSE CLINICAL GAINS RETURNED TO THE BASELINE LEVEL AT WEEK 16. CONCLUSIONS: THE RESULTS CONFIRMED THE BENEFICIAL EFFECTS OF THE YOGA THERAPY ON POSTURAL STABILITY IN PATIENTS WITH SCHIZOPHRENIA. HOWEVER, THE THERAPEUTIC EFFECTS SEEMED TRANSIENT, WHICH WARRANTS FURTHER INVESTIGATIONS ON STRATEGIES TO SUSTAIN THE IMPROVEMENTS. 2013 8 2403 28 YOGA AND EMOTION REGULATION IN HIGH SCHOOL STUDENTS: A RANDOMIZED CONTROLLED TRIAL. MIDDLE ADOLESCENTS (15-17 YEARS OLD) ARE PRONE TO INCREASED RISK TAKING AND EMOTIONAL INSTABILITY. EMOTION DYSREGULATION CONTRIBUTES TO A VARIETY OF PSYCHOSOCIAL DIFFICULTIES IN THIS POPULATION. A DISCIPLINE SUCH AS YOGA OFFERED DURING SCHOOL MAY INCREASE EMOTION REGULATION, BUT RESEARCH IN THIS AREA IS LACKING. THIS STUDY WAS DESIGNED TO EVALUATE THE IMPACT OF A YOGA INTERVENTION ON THE EMOTION REGULATION OF HIGH SCHOOL STUDENTS AS COMPARED TO PHYSICAL EDUCATION (PE). IN ADDITION, THE POTENTIAL MEDIATING EFFECTS OF MINDFUL ATTENTION, SELF-COMPASSION, AND BODY AWARENESS ON THE RELATIONSHIP BETWEEN YOGA AND EMOTION REGULATION WERE EXAMINED. HIGH SCHOOL STUDENTS WERE RANDOMIZED TO PARTICIPATE IN A 16-WEEK YOGA INTERVENTION (N = 19) OR REGULAR PE (N = 18). PRE-POST DATA ANALYSES REVEALED THAT EMOTION REGULATION INCREASED SIGNIFICANTLY IN THE YOGA GROUP AS COMPARED TO THE PE GROUP (F (1,32) = 7.50, P = .01, AND ETA(2) = .19). NO SIGNIFICANT RELATIONSHIP WAS DISCOVERED BETWEEN THE CHANGES IN EMOTION REGULATION AND THE PROPOSED MEDIATING VARIABLES. PRELIMINARY RESULTS SUGGEST THAT YOGA INCREASES EMOTION REGULATION CAPACITIES OF MIDDLE ADOLESCENTS AND PROVIDES BENEFITS BEYOND THAT OF PE ALONE. 2015 9 1789 28 PRELIMINARY INDICATIONS OF THE EFFECT OF A BRIEF YOGA INTERVENTION ON MARKERS OF INFLAMMATION AND DNA METHYLATION IN CHRONICALLY STRESSED WOMEN. YOGA IS ASSOCIATED WITH REDUCED STRESS AND INCREASED WELL-BEING, ALTHOUGH THE MOLECULAR BASIS FOR THESE BENEFITS IS NOT CLEAR. MOUNTING EVIDENCE IMPLICATES THE IMMUNE RESPONSE, WITH CURRENT STUDIES FOCUSED ON PROTEIN IMMUNE MARKERS (SUCH AS CYTOKINES) IN CLINICAL POPULATIONS. TO EXPLORE THE MOLECULAR IMPACT, THIS PILOT STUDY USES A SUBSAMPLE (N=28) FROM A RANDOMISED WAITLIST CONTROL TRIAL INVESTIGATING THE IMPACT OF AN 8-WEEK YOGA INTERVENTION IN A COMMUNITY POPULATION OF WOMEN REPORTING PSYCHOLOGICAL DISTRESS (N=116). WE MEASURED INTERLEUKIN-6 (IL-6), TUMOUR NECROSIS FACTOR (TNF) AND C-REACTIVE PROTEIN (CRP) PROTEIN LEVELS, AND THE DNA METHYLATION OF THESE GENES AND THE GLOBAL INDICATOR, LINE-1. CORRELATIONS BETWEEN THESE AND PSYCHOLOGICAL VARIABLES WERE EXPLORED, IDENTIFYING MODERATE CORRELATIONS WITH CRP PROTEIN LEVELS, AND METHYLATION OF IL-6, CRP AND LINE-1. MANY CYTOKINE SAMPLES WERE BELOW DETECTION, HOWEVER A MANN-WHITNEY U DEMONSTRATED A TREND OF MODERATE BETWEEN-GROUP EFFECT FOR ELEVATED IL-6 IN THE YOGA GROUP. METHYLATION ANALYSES APPLIED CROSS-SECTIONAL AND NON-CONTROLLED LONGITUDINAL ANALYSES. WAIST-TO-HEIGHT RATIO AND AGE WERE COVARIED. WE DEMONSTRATED REDUCED METHYLATION OF THE TNF REGION IN THE YOGA GROUP RELATIVE TO THE WAITLIST CONTROL GROUP. NO OTHER GENES DEMONSTRATED A SIGNIFICANT DIFFERENCE. LONGITUDINAL ANALYSIS FURTHER SUPPORTED THESE RESULTS. THIS STUDY IS ONE OF THE FIRST TO EXPLORE YOGA AND IMMUNOLOGICAL MARKERS IN A NON-CLINICAL POPULATION, AND IS THE FIRST STUDY TO EXPLORE DNA METHYLATION. THESE FINDINGS INDICATE THAT FURTHER RESEARCH INTO MOLECULAR IMPACT OF YOGA ON MARKERS OF IMMUNE FUNCTION IS WARRANTED, WITH LARGER STUDIES REQUIRED. 2016 10 1291 23 GROUP ACUPUNCTURE THERAPY WITH YOGA THERAPY FOR CHRONIC NECK, LOW BACK, AND OSTEOARTHRITIS PAIN IN SAFETY NET SETTING FOR AN UNDERSERVED POPULATION: DESIGN AND RATIONALE FOR A FEASIBILITY PILOT. CHRONIC PAIN IS PREVALENT IN THE UNITED STATES, WITH IMPACT ON PHYSICAL AND PSYCHOLOGICAL FUNCTIONING AS WELL AS LOST WORK PRODUCTIVITY. MINORITY AND LOWER SOCIOECONOMIC POPULATIONS HAVE INCREASED PREVALENCE OF CHRONIC PAIN WITH LESS ACCESS TO PAIN CARE, POORER OUTCOMES, AND HIGHER RISK OF FATAL OPIOID OVERDOSE. ACUPUNCTURE THERAPY IS EFFECTIVE IN TREATING CHRONIC PAIN CONDITIONS INCLUDING CHRONIC LOW BACK PAIN, NECK PAIN, SHOULDER PAIN, AND KNEE PAIN FROM OSTEOARTHRITIS. ACUPUNCTURE THERAPY, INCLUDING GROUP ACUPUNCTURE, IS FEASIBLE AND EFFECTIVE, AND SPECIFICALLY SO FOR UNDERSERVED AND DIVERSE POPULATIONS AT RISK FOR HEALTH OUTCOME DISPARITIES. ACUPUNCTURE THERAPY ALSO ENCOURAGES PATIENT ENGAGEMENT AND ACTIVATION. AS CHRONIC PAIN IMPROVES, THERE IS A NATURAL PROGRESSION TO WANT AND NEED TO INCREASE ACTIVITY AND MOVEMENT RECOVERY. DIVERSE MOVEMENT APPROACHES ARE IMPORTANT FOR IMPROVING RANGE OF MOTION, MAINTAINING GAINS, STRENGTHENING, AND PROMOTING PATIENT ENGAGEMENT AND ACTIVATION. YOGA THERAPY IS AN ACTIVE THERAPY WITH PROVEN BENEFIT IN MUSCULOSKELETAL PAIN DISORDERS AND PAIN ASSOCIATED DISABILITY. THE AIM OF THIS QUASI-EXPERIMENTAL PILOT FEASIBILITY TRIAL IS TO TEST THE BUNDLING OF THESE 2 EFFECTIVE CARE OPTIONS FOR CHRONIC PAIN, TO INFORM BOTH THE DESIGN FOR A LARGER RANDOMIZED PRAGMATIC EFFECTIVENESS TRIAL AS WELL AS IMPLEMENTATION STRATEGIES ACROSS UNDERSERVED SETTINGS. 2020 11 1394 23 IMPACT OF YOGA BASED LIFESTYLE INTERVENTION ON PSYCHOLOGICAL STRESS AND QUALITY OF LIFE IN THE PARENTS OF CHILDREN WITH RETINOBLASTOMA. BACKGROUND: CHILDHOOD CANCERS ARE ASSOCIATED WITH A PSYCHOLOGICAL BURDEN TO THE PARENTS AND HENCE, DECLINE THEIR MENTAL AND PHYSICAL HEALTH AND OVERALL QUALITY OF LIFE. PURPOSE: THE PURPOSE OF THE PRESENT STUDY IS TO INVESTIGATE THE IMPACT OF 12-WEEKS YOGA BASED LIFESTYLE INTERVENTION ON PSYCHOLOGICAL STRESS AND QUALITY OF LIFE IN THE PARENTS OF CHILDREN AFFECTED WITH RETINOBLASTOMA. METHOD: SINGLE ARM PROSPECTIVE CLINICAL TRIAL CONDUCTED FROM OCTOBER 2015 TO OCTOBER 2017 AT THE LABORATORY FOR MOLECULAR REPRODUCTION AND GENETICS, DEPARTMENT OF ANATOMY, ALL INDIA INSTITUTE OF MEDICAL SCIENCES, NEW DELHI, INDIA. A PRE-TESTED 12-WEEKS YOGA BASED LIFESTYLE INTERVENTION INCLUDED ASANAS (PHYSICAL POSTURES), PRANAYAMA (BREATHING EXERCISES), DHYANA (MEDITATION), RELAXATION TECHNIQUES, LECTURES AND FILMS ON YOGA, INTERACTIVE SESSIONS AND INDIVIDUALIZED ADVICE WAS ADMINISTERED TO THE PARTICIPANTS. RESULTS: 12-WEEKS OF YOGA BASED LIFESTYLE INTERVENTION PROGRAMME LEADS TO A SIGNIFICANT IMPROVEMENT IN PSYCHOLOGICAL STRESS AND OVERALL QUALITY OF LIFE IN THE PARENTS OF RETINOBLASTOMA PATIENTS. THERE WAS A SIGNIFICANT IMPROVEMENT IN ALL THE DOMAINS (PHYSICAL HEALTH, PSYCHOLOGICAL HEALTH, SOCIAL RELATIONSHIPS, AND ENVIRONMENT) OF WHOQOL-BREF FROM BASELINE (DAY 0) TO 12-WEEKS OF YOGA BASED LIFESTYLE INTERVENTION. YOGA BASED LIFESTYLE INTERVENTION ALSO LED TO A SIGNIFICANT INCREASE IN THE LEVELS OF BRAIN DERIVED NEUROTROPHIC FACTOR, DEHYDROEPIANDROSTERONE SULPHATE, SIRTUIN 1 AND DECREASED THE CORTISOL AND IL-6 LEVELS. CONCLUSION: YOGA BASED LIFESTYLE INTERVENTION REDUCED THE SEVERITY OF PSYCHOLOGICAL STRESS AND RESULTED IN IMPROVEMENT IN OVERALL QUALITY OF LIFE AND UPREGULATION IN LEVELS OF SYSTEMIC BIOMARKERS OF NEUROPLASTICITY. YBLI MAY SERVE AS A BENEFICIAL THERAPY AND MAY ALSO ACT AS AN EFFECTIVE MEDIUM FOR BETTER STRESS MANAGEMENT TO DEVELOP BETTER COPING STRATEGIES IN THE PARENTS OF RETINOBLASTOMA PATIENTS. 2019 12 702 37 EFFECT OF HOME-BASED TAI CHI, YOGA OR CONVENTIONAL BALANCE EXERCISE ON FUNCTIONAL BALANCE AND MOBILITY AMONG PERSONS WITH IDIOPATHIC PARKINSON'S DISEASE: AN EXPERIMENTAL STUDY. BACKGROUND: INDIVIDUALS WITH PARKINSON'S DISEASE (PD) INVARIABLY EXPERIENCE FUNCTIONAL DECLINE IN A NUMBER OF MOTOR AND NON-MOTOR DOMAINS AFFECTING POSTURE, BALANCE AND GAIT. NUMEROUS CLINICAL STUDIES HAVE EXAMINED EFFECTS OF VARIOUS TYPES OF EXERCISE ON MOTOR AND NON-MOTOR PROBLEMS. BUT STILL MUCH GAP REMAINS IN OUR UNDERSTANDING OF VARIOUS THERAPIES AND THEIR EFFECT ON DELAYING OR SLOWING THE DOPAMINE NEURON DEGENERATION. RECENTLY, TAI CHI AND YOGA BOTH HAVE GAINED POPULARITY AS COMPLEMENTARY THERAPIES, SINCE BOTH HAVE COMPONENTS FOR MIND AND BODY CONTROL. OBJECTIVE: THE AIM OF THIS STUDY WAS TO DETERMINE WHETHER EIGHT WEEKS OF HOME-BASED TAI CHI OR YOGA WAS MORE EFFECTIVE THAN REGULAR BALANCE EXERCISES ON FUNCTIONAL BALANCE AND MOBILITY. METHODS: TWENTY-SEVEN INDIVIDUALS WITH IDIOPATHIC PD (MODIFIED HOEHN AND YAHR STAGES 2.5-3) WERE RANDOMLY ASSIGNED TO EITHER TAI CHI, YOGA OR CONVENTIONAL EXERCISE GROUP. ALL THE PARTICIPANTS WERE EVALUATED FOR FUNCTIONAL BALANCE AND MOBILITY USING BERG BALANCE SCALE, TIMED 10 M WALK TEST AND TIMED UP AND GO TEST BEFORE AND AFTER EIGHT WEEKS OF TRAINING. RESULTS: THE RESULTS WERE ANALYZED USING TWO-WAY MIXED ANOVA WHICH SHOWED THAT THERE WAS A SIGNIFICANT MAIN EFFECT FOR TIME AS F (1, 24) = 74.18, P = 0 . 000 , ETA P 2 = 0 . 76 FOR OVERALL BALANCE IN BERG BALANCE SCALE. THERE WAS ALSO SIGNIFICANT MAIN EFFECT OF TIME ON MOBILITY OVERALL AS F(1, 24) = 77 . 78 , P = 0 . 000 , ETA P 2 = 0 . 76 IN TIMED UP AND GO TEST AND F(1, 24) = 48 . 24 , P = 0 . 000 , ETA P 2 = 0 . 67 FOR 10 M WALK TEST. THERE WAS A SIGNIFICANT INTERACTION EFFECT FOR TIME X GROUP WITH F(2, 24) = 8 . 67 , P = 0 . 001 , ETA P 2 = 0 . 420 FOR BALANCE. WITH RESPECT TO MOBILITY, THE VALUES F(2, 24) = 5 . 92 , P = 0 . 008 , ETA P 2 = 0 . 330 IN TIMED UP AND GO TEST AND F(2, 24) = 10 . 40 , P = 0 . 001 , ETA P 2 = 0 . 464 IN 10 M WALK TEST SHOWED A SIGNIFICANT INTERACTION. BUT THERE WAS NO SIGNIFICANT MAIN EFFECT BETWEEN THE GROUPS FOR BOTH BALANCE AND MOBILITY. CONCLUSION: THE FINDINGS OF THIS STUDY SUGGEST THAT TAI CHI AS WELL AS YOGA ARE WELL ADHERED AND ARE ATTRACTIVE OPTIONS FOR A HOME-BASED SETTING. AS ANY FORM OF PHYSICAL ACTIVITY IS CONSIDERED BENEFICIAL FOR INDIVIDUALS WITH PD EITHER TAI CHI, YOGA OR CONVENTIONAL BALANCE EXERCISES COULD BE USED AS THERAPEUTIC INTERVENTION TO OPTIMIZE BALANCE AND MOBILITY. FURTHER STUDIES ARE NECESSARY TO UNDERSTAND THE MIND-BODY BENEFITS OF TAI CHI AND YOGA EITHER AS MULTICOMPONENT PHYSICAL ACTIVITIES OR AS INDIVIDUAL THERAPIES IN VARIOUS STAGES OF PD. 2020 13 1276 21 FUNCTIONAL IMPROVEMENTS IN PARKINSON'S DISEASE FOLLOWING A RANDOMIZED TRIAL OF YOGA. INDIVIDUALS WITH PARKINSON'S DISEASE (PD) EXPERIENCE SIGNIFICANT LIMITATIONS IN MOTOR FUNCTION, FUNCTIONAL GAIT, POSTURAL STABILITY, AND BALANCE. THESE LIMITATIONS OFTEN LEAD TO HIGHER INCIDENCES OF FALLS, WHICH HAVE SIGNIFICANT COMPLICATIONS FOR INDIVIDUALS WITH PD. YOGA MAY IMPROVE THESE FUNCTIONAL DEFICITS IN INDIVIDUALS WITH PD. THE OBJECTIVE OF THIS STUDY WAS TO DETERMINE CHANGES IN MOTOR FUNCTION, FUNCTIONAL GAIT, POSTURAL STABILITY, AND BALANCE CONTROL FOR COMMUNITY DWELLING INDIVIDUALS WITH PD. THIS RANDOMIZED, WAIT-LIST CONTROLLED PILOT STUDY EXAMINED THE INFLUENCE OF AN 8-WEEK YOGA INTERVENTION FOR PEOPLE WITH PD WHO MET THE FOLLOWING INCLUSION CRITERIA: ENDORSING A FEAR OF FALLING, BEING ABLE TO SPEAK ENGLISH, SCORING 4/6 ON THE MINIMENTAL STATE EXAM, AND BEING WILLING TO ATTEND THE INTERVENTION TWICE WEEKLY FOR 8-WEEKS. PARTICIPANTS IN THE YOGA GROUP (N=15) EXPERIENCED IMPROVEMENTS IN MOTOR FUNCTION, POSTURAL STABILITY, FUNCTIONAL GAIT, AND FREEZING GAIT, AS WELL AS REDUCTIONS IN FALL RISK. PARTICIPANTS IN THE WAIT-LIST CONTROL (N=12) ALSO SIGNIFICANTLY IMPROVED IN POSTURAL STABILITY, ALTHOUGH THEIR FALL RISK WAS NOT REDUCED. INDIVIDUALS IN THE YOGA GROUP SIGNIFICANTLY REDUCED THEIR FALL RISK. AN 8-WEEK YOGA INTERVENTION MAY REDUCE FALL RISK AND IMPROVE POSTURAL STABILITY, AND FUNCTIONAL AND FREEZING GAIT IN INDIVIDUALS WITH PD. THIS CLINICAL TRIAL IS REGISTERED AS PROTOCOL RECORD PRO00041068 IN CLINICALTRIALS.GOV. 2018 14 358 28 ASSOCIATION BETWEEN YOGA, PHYSIOLOGIC AND PSYCHOLOGIC HEALTH: A CROSS SECTIONAL STUDY. PURPOSE: TO COMPARE MARKERS OF HEALTH ASSOCIATED WITH CHRONIC DISEASES BETWEEN YOGA AND NON-YOGA PARTICIPANTS. METHODS: 30 PARTICIPANTS WERE CATEGORIZED AS EITHER: 1) "YOGA" ENGAGING IN YOGA >/=2 TIMES/WEEK FOR >/=6 MONTHS, OR 2) "NON-YOGA" NOT ENGAGING IN YOGA. RESULTS: PERCEIVED STRESS SCALE (PSS) AND BECK DEPRESSION INVENTORY-II (BDI-II) SCORES WERE SIGNIFICANTLY DIFFERENT BETWEEN THE YOGA AND NON-YOGA GROUPS (PSS: 8.0 VS. 17.5, RESPECTIVELY, P < 0.05; BDI-II: 1.0 VS. 5.5, RESPECTIVELY, P < 0.05). NO SIGNIFICANT DIFFERENCES WERE EVIDENT BETWEEN GROUPS FOR INFLAMMATORY MARKERS NOR COMPLEX V OF THE MITOCHONDRIAL ELECTRON TRANSPORT CHAIN. THE ERYTHROCYTE SEDIMENTATION RATE VALUES DIFFERED BETWEEN GROUPS BASED ON CLINICAL CUTOFFS, WITH YOGA PARTICIPANTS CATEGORIZED AS NORMAL (11.0 MM) AND NON-YOGA ABOVE NORMAL (21.5 MM). CONCLUSION: THIS RESEARCH SUPPORTS THAT YOGA PARTICIPATION IS ASSOCIATED WITH LOWER PSS AND BDI-II SCORES BUT DOES NOT SUPPORT A RELATIONSHIP WITH MARKERS OF INFLAMMATION. FURTHER RESEARCH IS WARRANTED. 2021 15 2299 32 THERAPEUTIC YOGA FOR THE MANAGEMENT OF CHRONIC NONSPECIFIC NECK PAIN: CURRENT EVIDENCE AND MECHANISMS. CHRONIC NONSPECIFIC NECK PAIN (CNNP), WHICH IS NECK PAIN IN THE ABSENCE OF ATTRIBUTABLE STRUCTURAL AND NEUROLOGICAL FINDINGS, IS OFTEN CHALLENGING FOR MEDICAL AND REHABILITATION PROFESSIONALS TO TREAT. CONVENTIONAL TREATMENTS SUCH AS MEDICATIONS AND PHYSICAL THERAPY OFTEN FAIL TO PROVIDE LASTING RELIEF, WHICH LEADS PATIENTS TO PURSUE COMPLEMENTARY THERAPIES SUCH AS YOGA. THIS REVIEW DISCUSSES THE EVIDENCE FROM NINE STUDIES, INCLUDING FOUR RANDOMIZED CONTROLLED TRIALS, WHICH SUGGESTS THAT A SUPERVISED YOGA PROGRAM MAY DECREASE PAIN INTENSITY, DISABILITY, AND MOOD SYMPTOMS IN ADULTS WITH CNNP. CERVICAL RANGE OF MOTION AND QUALITY OF LIFE (BOTH PHYSICAL AND MENTAL) MAY ALSO IMPROVE WITH YOGA INTERVENTION, ALTHOUGH THIS IS LESS CONSISTENT ACROSS STUDIES. EVIDENCE OF YOGA'S SUPERIORITY TO OTHER EXERCISE-BASED PRACTICES SUCH AS PILATES WAS CONFLICTING. ADVERSE EFFECTS OF YOGA, SUCH AS EXACERBATION OF NECK PAIN, WERE RELATIVELY UNCOMMON, MINOR, AND OFTEN TRANSIENT. THIS ARTICLE ALSO COMPREHENSIVELY REVIEWS THE PATHOPHYSIOLOGY OF CNNP, THERAPEUTIC MECHANISMS OF YOGA, AND LIMITATIONS IN THE EVIDENCE (INCLUDING RISK-OF-BIAS ASSESSMENT). FUTURE STUDIES SHOULD ATTEMPT TO: (1) COMPARE THE EFFECTIVENESS OF DIFFERENT LINEAGES OF YOGA FOR INDIVIDUALS WITH CNNP, (2) DETERMINE THE OPTIMAL LENGTH AND DURATION OF THESE YOGA INTERVENTIONS, (3) BETTER CHARACTERIZE THE PHYSICAL AND PSYCHOLOGICAL MECHANISMS OF YOGA, (4) COMPARE YOGA TO OTHER EXERCISE- AND MINDFULNESS-BASED PRACTICES, (5) EVALUATE THE EFFECT OF YOGA ON SLEEP IN THE CNNP POPULATION, AND (6) EXPLORE THE APPLICABILITY/EFFICACY OF VIRTUAL YOGA INSTRUCTION. 2022 16 1675 20 OBESITY-RELATED INFLAMMATION & CARDIOVASCULAR DISEASE: EFFICACY OF A YOGA-BASED LIFESTYLE INTERVENTION. OBESITY IS A GLOBAL HEALTH BURDEN AND ITS PREVALENCE IS INCREASING SUBSTANTIALLY DUE TO CHANGING LIFESTYLE. CHRONIC ADIPOSITY IS ASSOCIATED WITH METABOLIC IMBALANCE LEADING TO DYSLIPIDAEMIA, DIABETES, HYPERTENSION AND CARDIOVASCULAR DISEASES (CVD). ADIPOSE TISSUE ACTS AS AN ENDOCRINE ORGAN RELEASING SEVERAL ADIPOCYTOKINES, AND IS ASSOCIATED WITH INCREASED LEVELS OF TISSUE AND CIRCULATING INFLAMMATORY BIOMOLECULES CAUSING VASCULAR INFLAMMATION AND ATHEROGENESIS. FURTHER, INFLAMMATION IS ALSO ASSOCIATED INDEPENDENTLY WITH OBESITY AS WELL AS CVD. KEEPING THIS IN VIEW, IT IS POSSIBLE THAT A REDUCTION IN WEIGHT MAY LEAD TO A DECREASE IN INFLAMMATION, RESULTING IN CVD RISK REDUCTION, AND BETTER MANAGEMENT OF PATIENTS WITH CVD. LIFESTYLE INTERVENTION HAS BEEN ENDORSED BY SEVERAL HEALTH AUTHORITIES IN PREVENTION AND MANAGEMENT OF CHRONIC DISEASES. A YOGA-BASED LIFESTYLE INTERVENTION APPEARS TO BE A PROMISING OPTION IN REDUCING THE RISK FOR CVD AS WELL AS MANAGEMENT OF PATIENTS WITH CVD AS IT IS SIMPLE TO FOLLOW AND COST-EFFECTIVE WITH HIGH COMPLIANCE. THE EFFICACY OF SUCH LIFESTYLE INTERVENTION PROGRAMMES IS MULTIFACETED, AND IS ACHIEVED VIA REDUCTION IN WEIGHT, OBESITY-RELATED INFLAMMATION AND STRESS, THEREBY CULMINATING INTO RISK REDUCTION TOWARDS SEVERAL CHRONIC DISEASES INCLUDING CVD. IN THIS REVIEW, THE ASSOCIATION BETWEEN OBESITY-RELATED INFLAMMATION AND CVD, AND THE ROLE OF YOGA-BASED LIFESTYLE INTERVENTION IN PREVENTION AND MANAGEMENT OF CVD ARE DISCUSSED. 2014 17 681 36 EFFECT OF ADD-ON YOGA ON COGNITIVE FUNCTIONS AMONG SUBSTANCE ABUSERS IN A RESIDENTIAL THERAPEUTIC CENTER: RANDOMIZED COMPARATIVE STUDY. BACKGROUND: CHRONIC VULNERABILITY CHARACTERIZES SUBSTANCE ABUSE DISORDER WITH CONSEQUENT RELAPSE. THE PROCESS OF ABSTINENCE DEPENDS ON COGNITIVE RECOVERY. HENCE, BEHAVIORAL INTERVENTION SHOULD ACCOUNT FOR COGNITIVE DIMENSION OF SUBSTANCE ABUSERS. RECENT STUDIES HIGHLIGHT YOGA-BASED INTERVENTION AS A PROMISING ADD-ON THERAPY FOR TREATING AND PREVENTING ADDICTIVE BEHAVIORS. PURPOSE: THE STUDY AIMED TO EVALUATE THE EFFICACY OF A YOGA-BASED INTERVENTION AS AN ADD-ON IN ENHANCING COGNITIVE FUNCTIONS, COMPARED WITH PHYSICAL EXERCISE TO NEWLY ADMITTED SUBSTANCE ABUSERS SEEKING AN INPATIENT TREATMENT PROGRAM. METHODS: THE STUDY WAS A SINGLE-BLIND, RANDOMIZED, COMPARATIVE DESIGN THAT INCLUDED 96 MALE PARTICIPANTS, BETWEEN 18 AND 40 YEARS IN A RESIDENTIAL REHABILITATION TREATMENT UNIT. PARTAKERS IN THE YOGA OR PHYSICAL EXERCISE GROUP RECEIVED SUPERVISED DAILY TRAINING FOR 12 WEEKS, IN ADDITION TO STANDARD REHABILITATION TREATMENT. RATERS BLIND TO THE STUDY ASSESSED THE PATIENTS ON DIGIT SPAN TASK, CANCELLATION TEST, AND STROOP TESTS AT THE BASELINE AND FOLLOWING 12 WEEKS OF INTERVENTION. RESULTS: A SIGNIFICANT ENHANCEMENT IN DIGIT FORWARD (YOGA - P < 0.0005, D = 0.81; EXERCISE - P < 0.0005, D = 0.73), DIGIT BACKWARD (YOGA - P < 0.0005, D = 0.88; EXERCISE - P < 0.0005, D = 0.58), AND LETTER CANCELLATION TEST SCORES (YOGA - P < 0.0005, D = 1.31; EXERCISE - P < 0.0005, D = 1.4) WERE OBSERVED IN BOTH THE YOGA AND THE EXERCISE GROUPS. STROOP WORD AND COLOR TASK SCORES WERE SEEN SIGNIFICANTLY HIGHER FOLLOWING YOGA (P < 0.005, D = 0.74; P < 0.005, D = 1.13) AND EXERCISE (P < 0.0005, D = 0.62; P < 0.0005, D = 0.61). FURTHERMORE, STROOP COLOR-WORD TEST SHOWED SIGNIFICANT ENHANCEMENT AFTER YOGA (P < 0.0005, D = 1.10) AND EXERCISE (P < 0.0005, D = 0.42), WITH DEGREE OF VARIATION HIGHER IN THE YOGA GROUP. CONCLUSION: OUR RESULTS SUGGEST THAT THE ADD-ON YOGA OR EXERCISE-BASED INTERVENTION SHOW ENHANCEMENT OF COGNITIVE FUNCTIONS. THESE FINDINGS PROVIDE THE UTILITY OF YOGA AND EXERCISE-BASED INTERVENTION IN IMPROVING COGNITIVE FUNCTIONS AMONG SUBSTANCE ABUSERS. FURTHERMORE, RIGOROUS TRIALS ARE NEEDED TO EXPLORE THE POTENTIAL LONG-TERM EFFECTS OF THESE PROCEDURES. 2018 18 835 33 EFFECT OF YOGA ON PAIN, BRAIN-DERIVED NEUROTROPHIC FACTOR, AND SEROTONIN IN PREMENOPAUSAL WOMEN WITH CHRONIC LOW BACK PAIN. BACKGROUND. SEROTONIN AND BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) ARE KNOWN TO BE MODULATORS OF NOCICEPTION. HOWEVER, PAIN-RELATED CONNECTION BETWEEN YOGA AND THOSE NEUROMODULATORS HAS NOT BEEN INVESTIGATED. THEREFORE, WE AIMED TO EVALUATE THE EFFECT OF YOGA ON PAIN, BDNF, AND SEROTONIN. METHODS. PREMENOPAUSAL WOMEN WITH CHRONIC LOW BACK PAIN PRACTICED YOGA THREE TIMES A WEEK FOR 12 WEEKS. AT BASELINE AND AFTER 12 WEEKS, BACK PAIN INTENSITY WAS MEASURED USING VISUAL ANALOGUE SCALE (VAS), AND SERUM BDNF AND SEROTONIN LEVELS WERE EVALUATED. ADDITIONALLY, BACK FLEXIBILITY AND LEVEL OF DEPRESSION WERE ASSESSED. RESULTS. AFTER 12-WEEK YOGA, VAS DECREASED IN THE YOGA GROUP (P < 0.001), WHEREAS IT INCREASED (P < 0.05) IN THE CONTROL GROUP. BACK FLEXIBILITY WAS IMPROVED IN THE YOGA GROUP (P < 0.01). SERUM BDNF INCREASED IN THE YOGA GROUP (P < 0.01), WHEREAS IT TENDED TO DECREASE IN THE CONTROL GROUP (P = 0.05). SERUM SEROTONIN MAINTAINED IN THE YOGA GROUP, WHILE IT REDUCED (P < 0.01) IN THE CONTROL GROUP. THE DEPRESSION LEVEL MAINTAINED IN THE YOGA GROUP, WHEREAS IT TENDED TO INCREASE IN THE CONTROL GROUP (P = 0.07). CONCLUSIONS. WE PROPOSE THAT BDNF MAY BE ONE OF THE KEY FACTORS MEDIATING BENEFICIAL EFFECTS OF YOGA ON CHRONIC LOW BACK PAIN. 2014 19 938 30 EFFECTS OF 1-YEAR YOGA ON CARDIOVASCULAR RISK FACTORS IN MIDDLE-AGED AND OLDER ADULTS WITH METABOLIC SYNDROME: A RANDOMIZED TRIAL. BACKGROUND: METABOLIC SYNDROME (METS) IS A CLUSTERING OF CARDIOVASCULAR RISK FACTORS, WHICH IS ASSOCIATED WITH DIABETES MELLITUS AND CARDIOVASCULAR DISEASE. LIFESTYLE INTERVENTIONS APPLIED TO PEOPLE WITH METS HAS CONSIDERABLE BENEFICIAL EFFECTS ON DISEASE PREVENTIVE OUTCOMES. THIS STUDY AIMED TO EXAMINE THE EFFECTS OF 1-YEAR OF YOGA EXERCISE ON THE CARDIOVASCULAR RISK FACTORS INCLUDING CENTRAL OBESITY, HYPERTENSION, DYSLIPIDEMIA AND HYPERGLYCEMIA IN MIDDLE-AGED AND OLDER HONG KONG CHINESE ADULTS WITH METS. METHODS: ADULTS DIAGNOSED WITH METS USING NATIONAL CHOLESTEROL EDUCATION PROGRAM CRITERIA (N = 182; MEAN +/- SD AGE = 56 +/- 9.1) WERE RANDOMLY ASSIGNED TO A 1-YEAR YOGA INTERVENTION GROUP OR CONTROL GROUP. SYSTOLIC AND DIASTOLIC BLOOD PRESSURE, WAIST CIRCUMFERENCE, FASTING PLASMA GLUCOSE, TRIGLYCERIDES, AND HIGH-DENSITY LIPOPROTEIN CHOLESTEROL WERE EXAMINED AT BASELINE, MIDWAY, AND ON COMPLETION OF THE STUDY. PHYSICAL ACTIVITY LEVEL AND CALORIC INTAKE WERE ASSESSED AND INCLUDED IN THE COVARIATE ANALYSES. RESULTS: A REDUCTION OF THE NUMBER OF DIAGNOSTIC COMPONENTS FOR METS WAS FOUND TO BE ASSOCIATED WITH THE YOGA INTERVENTION. WAIST CIRCUMFERENCE WAS SIGNIFICANTLY IMPROVED AFTER THE 1-YEAR YOGA INTERVENTION. A TREND TOWARDS A DECREASE IN SYSTOLIC BLOOD PRESSURE WAS OBSERVED FOLLOWING YOGA INTERVENTION. CONCLUSION: THESE RESULTS SUGGEST THAT YOGA EXERCISE IMPROVES THE CARDIOVASCULAR RISK FACTORS INCLUDING CENTRAL OBESITY AND BLOOD PRESSURE IN MIDDLE-AGED AND OLDER ADULTS WITH METS. THESE FINDINGS SUPPORT THE COMPLEMENTARY BENEFICIAL ROLE OF YOGA IN MANAGING METS. 2015 20 2412 23 YOGA AND ITS IMPACT ON CHRONIC INFLAMMATORY AUTOIMMUNE ARTHRITIS. RHEUMATOID ARTHRITIS (RA) IS ONE OF THE MOST COMMON CHRONIC INFLAMMATORY AUTOIMMUNE DISEASES, WHICH ADVERSELY AFFECTS THE QUALITY OF LIFE. RA IS A DISEASE OF UNKNOWN ETIOLOGY, HOWEVER, BOTH GENETIC AND ENVIRONMENTAL FACTORS APPEAR TO CONTRIBUTE TO THE SUSCEPTIBILITY TO THIS DISEASE. THE SEVERITY AND PROGRESSION OF THE DISEASE ARE ATTRIBUTABLE TO THE RELEASE OF A HOST OF INFLAMMATORY CYTOKINES, CYTOTOXIC AND IMMUNE REGULATORY FACTORS. THE TREATMENTS OF RA ARE PRIMARILY LIMITED TO SYMPTOMATIC ALLEVIATION OF PAIN OR OTHER SYMPTOMS OR TO THE USE OF CYTOTOXIC DRUG TREATMENT IN SEVERE FORMS OF THE DISEASE WHICH IS COMMONLY ASSOCIATED WITH SIGNIFICANT SIDE EFFECTS. DESPITE LACK OF A CURE, THE DISEASE MAY BE CONTROLLED BY MIND-BODY INTERVENTIONS. HOLISTIC TREATMENTS SUCH AS YOGA SIGNIFICANTLY IMPROVE AND REDUCE THE PSYCHO-SOMATIC SYMPTOMS, PAIN PERCEPTION, DISABILITY QUOTIENT, JOINT FLEXIBILITY, RANGE OF MOTION, POSTURE, MUSCLE STRENGTH, COORDINATION, AND DISEASE ACTIVITY. HERE, WE DISCUSS THE FEATURES OF RA AND ADDRESS HOW YOGA CAN BE USED AS A THERAPEUTIC REGIMEN TO IMPROVE THE QUALITY OF LIFE OF PATIENTS WITH RA. 2021