1 2608 48 YOGA FOR PSYCHIATRIC DISORDERS: FROM FAD TO EVIDENCE-BASED INTERVENTION? THERE IS GROWING EVIDENCE FOR YOGA'S NEUROBIOLOGICAL EFFECTS IN PEOPLE WITH PSYCHIATRIC DISORDERS. POSTULATED MECHANISMS OF ACTION INCLUDE: (A) MODULATION OF THE HYPOTHALAMIC-PITUITARY-ADRENAL (HPA) AXIS; (B) ENHANCEMENT OF GABAERGIC NEUROTRANSMISSION; (C) AUTONOMIC MODULATION; AND (D) NEUROENDOCRINOLOGICAL EFFECTS. YOGA AS A THERAPEUTIC INTERVENTION IN PSYCHIATRIC DISORDERS APPEARS PROMISING AND MERITS FURTHER ATTENTION IN CLINICAL PRACTICE AND RESEARCH.	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
2  988 21 EFFECTS OF HATHA YOGA ON BLOOD PRESSURE, SALIVARY ALPHA-AMYLASE, AND CORTISOL FUNCTION AMONG NORMOTENSIVE AND PREHYPERTENSIVE YOUTH. OBJECTIVE: EVIDENCE IS ACCUMULATING, PREDOMINANTLY AMONG CLINICAL TRIALS IN ADULTS, THAT YOGA IMPROVES BLOOD PRESSURE (BP) CONTROL, WITH DOWNREGULATION OF THE HYPOTHALAMIC-PITUITARY-ADRENAL (HPA) AXIS AND THE SYMPATHETIC NERVOUS SYSTEM (SNS) PROJECTED AS UNDERLYING MECHANISMS. THIS PILOT STUDY ASSESSED WHETHER HATHA YOGA HAS THE POTENTIAL TO REDUCE BP AMONG YOUTH AND WHETHER DAMPENING OF THE SNS AND/OR HPA ACTIVITY IS A LIKELY PATHWAY OF CHANGE. DESIGN: THIRTY-ONE SEVENTH GRADERS WERE RANDOMLY ASSIGNED TO A HATHA YOGA PROGRAM (HYP) OR ATTENTION CONTROL (AC) MUSIC OR ART CLASS. BASELINE AND 3-MONTH EVALUATIONS INCLUDED RESTING BP; OVERNIGHT URINE SAMPLES; AND SALIVA COLLECTED AT BEDTIME, UPON AWAKENING, AND AT 30 AND 60 MINUTES AFTER AWAKENING FOR ALPHA-AMYLASE AND CORTISOL ASSAYS. RESULTS: TWENTY-EIGHT (14 IN THE HYP GROUP AND 14 IN THE AC GROUP) STUDENTS WERE ASSESSED BOTH BEFORE AND AFTER THE INTERVENTION. BP CHANGES FROM PRE- TO POST-INTERVENTION WERE -3.0/-2.0 MMHG FOR THE HYP GROUP AND -0.07/-0.79 MMHG FOR THE AC GROUP (P=0.30 AND 0.57, RESPECTIVELY). CHANGES IN SYSTOLIC BP (SBP)/DIASTOLIC BP (DBP) FOR THE PREHYPERTENSIVE (75TH-94TH PERCENTILES FOR SBP) SUBGROUP ANALYSES WERE -10.75/-8.25 MMHG FOR THE HYP GROUP (N=4) VERSUS 1.8/1.0 MMHG FOR THE AC GROUP (N=5) (P FOR SBP=0.02; P FOR DBP=0.09). ALTHOUGH NO STATISTICALLY SIGNIFICANT GROUP DIFFERENCES WERE OBSERVED WITH CHANGES IN SNS OR HPA AWAKENING CURVES (AREA UNDER CURVE FOR ALPHA-AMYLASE AND CORTISOL, RESPECTIVELY), A SMALL TO MODERATE EFFECT SIZE WAS SEEN FAVORING A REDUCTION OF ALPHA-AMYLASE ACTIVATION FOR THE HYP GROUP (COHEN D=0.34; PREHYPERTENSIVE D=0.20). CONCLUSIONS: A SCHOOL-BASED HATHA YOGA PROGRAM DEMONSTRATED POTENTIAL TO DECREASE RESTING BP, PARTICULARLY AMONG PREHYPERTENSIVE YOUTH. REDUCED SNS DRIVE MAY BE AN UNDERLYING NEUROHORMONAL PATHWAY BENEFICIALLY AFFECTED BY THE PROGRAM. A LARGE-SCALE EFFICACY/EFFECTIVENESS RANDOMIZED CLINICAL TRIAL IS WARRANTED.	2014	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
3 2241 14 THE INFLUENCE OF HATHA YOGA AS AN ADD-ON TREATMENT IN MAJOR DEPRESSION ON HYPOTHALAMIC-PITUITARY-ADRENAL-AXIS ACTIVITY: A RANDOMIZED TRIAL. OBJECTIVES: THE IMPACT OF HATHA YOGA AS ADD-ON TREATMENT TO QUETIAPINE FUMARATE EXTENDED RELEASE (QXR) OR ESCITALOPRAM (ESC) IN DEPRESSED PATIENTS ON HYPOTHALAMIC-PITUITARY-ADRENAL (HPA) AXIS ACTIVITY WAS ASSESSED. METHODS: 60 INPATIENTS SUFFERING FROM MAJOR DEPRESSIVE DISORDER (MDD) ACCORDING TO DSM-IV WERE RANDOMIZED FOR A 5 WEEK TREATMENT WITH YOGA OR NOT (CONTROL GROUP) AND WITH EITHER QXR (300 MG/DAY) OR ESC (10 MG/DAY). SERIAL DEXAMETHASONE/CORTICOTROPIN RELEASING HORMONE (DEX/CRH) TESTS WERE PERFORMED TO ASSESS HPA AXIS FUNCTION. THE HAMILTON DEPRESSION RATING SCALE (21-HAMD) WAS USED WEEKLY. RESULTS: A MORE PRONOUNCED DOWN REGULATION OF THE HPA AXIS ACTIVITY DUE TO YOGA COULD NOT BE DETECTED. THE STEPWISE LONG TERM CORTISOL REDUCTION WAS SEEN IN BOTH MEDICATION GROUPS, IRRESPECTIVELY OF YOGA ADD-ON TREATMENT. IN ADDITION, CORTISOL IMPROVERS IN WEEK 1 OF THERAPY (REDUCTION IN CORTISOL PEAK VALUE WITHIN THE DEX/CRH TEST) REACHED SIGNIFICANT GREATER AMELIORATION OF DEPRESSIVE SYMPTOMS AFTER 5 WEEKS. CONCLUSIONS: OUR RESULTS SUGGEST THAT ANTIDEPRESSANT AGENTS DOWN REGULATE HPA AXIS FUNCTION TO A GREATER EXTENT THAN ADDITIONAL HATHA YOGA TREATMENT. MOREOVER, AN EARLY REDUCTION OF HPA SYSTEM HYPERACTIVITY AFTER ONE WEEK OF PHARMACOLOGICAL TREATMENT SEEMS TO RAISE THE POSSIBILITY OF A FAVORABLE TREATMENT RESPONSE.	2014	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
4 2790 17 YOGA THERAPY FOR ANXIETY: A CASE REPORT. YOGA THERAPY IS A MIND-BODY INTERVENTION THAT CAN BE AN IMPORTANT SOLUTION IN THE TREATMENT OF ANXIETY. YOGA THERAPY ALLEVIATES THE HYPERAROUSAL OF THE SYMPATHETIC NERVOUS SYSTEM (SNS) AND THE HYPERVIGILANCE OF THE HYPOTHALAMIC-PITUITARY-ADRENAL (HPA) AXIS THAT OCCURS IN ANXIETY. YOGA THERAPY ACTIVATES THE PARASYMPATHETIC BRANCH OF THE NERVOUS SYSTEM, REPLACING SNS OVERDRIVE, OR THE FLIGHT-OR-FIGHT RESPONSE, WITH THE RELAXATION RESPONSE AND BALANCING THE NERVOUS SYSTEM. YOGA THERAPY INCREASES POSITIVE COPING SKILLS AND BUILDS SELF-ESTEEM WITHOUT HARMFUL SIDE EFFECTS. THE RESULTS OF THIS CASE STUDY HAVE DEMONSTRATED THE CLINICAL EFFICACY OF YOGA THERAPY IN THE TREATMENT OF ANXIETY AND PANIC DISORDER (PD) IN AN ADOLESCENT FEMALE. TREATMENT CONSISTED OF 4 WKS OF INDIVIDUAL SESSIONS (60-MIN SESSION/WK) AND 6 WKS OF GROUP SESSIONS (90-MIN SESSION/WK) WITH DAILY HOME PRACTICE. THE RESULTS OF THE CASE STUDY ARE SIGNIFICANT BECAUSE GROWING NUMBERS OF YOUTH IN THE UNITED STATES ARE PRESENTING WITH ANXIETY AND SEEKING NONPHARMACOLOGICAL OPTIONS.	2013	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
5 1824 20 PSYCHO-NEURO-ENDOCRINE-IMMUNE MECHANISMS OF ACTION OF YOGA IN TYPE II DIABETES. YOGA HAS BEEN FOUND TO BENEFIT ALL THE COMPONENTS OF HEALTH VIZ. PHYSICAL, MENTAL, SOCIAL AND SPIRITUAL WELL BEING BY INCORPORATING A WIDE VARIETY OF PRACTICES. PATHOPHYSIOLOGY OF TYPE II DM AND CO-MORBIDITIES IN TYPE II DM HAS BEEN CORRELATED WITH STRESS MECHANISMS. STRESS SUPPRESSES BODY'S IMMUNE SYSTEM AND NEURO-HUMORAL ACTIONS THEREBY AFF ECTING NORMAL PSYCHOLOGICAL STATE. IT WOULD NOT BE WRONG TO STATE THAT CORRELATION OF DIABETES WITH STRESS, ANXIETY AND OTHER PSYCHOLOGICAL FACTORS ARE BIDIRECTIONAL AND LEAD TO DIFFICULTY IN UNDERSTANDING THE INTERRELATED MECHANISMS. TYPE II DM CANNOT BE UNDERSTOOD IN ISOLATION WITH PSYCHOLOGICAL FACTORS SUCH AS STRESS, ANXIETY AND DEPRESSION, NEURO-ENDOCRINE AND IMMUNOLOGICAL FACTORS. THERE IS NO REVIEW WHICH TRIES TO UNDERSTAND THESE MECHANISMS EXCLUSIVELY. THE PRESENT LITERATURE REVIEW AIMS TO UNDERSTAND INTERRELATED PSYCHO-NEURO-ENDOCRINE AND IMMUNOLOGICAL MECHANISMS OF ACTION OF YOGA IN TYPE II DIABETES MELLITUS. PUBLISHED LITERATURE CONCERNING MECHANISMS OF ACTION OF YOGA IN TYPE II DM EMPHASIZING PSYCHO-NEURO-ENDOCRINE OR IMMUNOLOGICAL RELATIONS WAS RETRIEVED FROM PUBMED USING KEY WORDS YOGA, TYPE II DIABETES MELLITUS, PSYCHOLOGICAL, NEURAL, ENDOCRINE, IMMUNE AND MECHANISM OF ACTION. THOSE STUDIES WHICH EXPLAINED THE PSYCHO-NEUROENDOCRINE AND IMMUNE MECHANISMS OF ACTION OF YOGA WERE INCLUDED AND REST WERE EXCLUDED. ALTHOUGH PRIMARY AIM OF THIS STUDY IS TO EXPLAIN THESE MECHANISMS IN TYPE II DM, SOME STUDIES IN NON-DIABETIC POPULATION WHICH HAD A SIMILAR PATHWAY OF STRESS MECHANISM WAS INCLUDED BECAUSE MANY INSIGHTFUL STUDIES WERE AVAILABLE IN THAT AREA. SEARCH WAS CONDUCTED USING TERMS YOGA OR YOGIC AND DIABETES OR DIABETIC IN TITLE OR ABSTRACT FOR ENGLISH ARTICLES. OF THE 89 ARTICLES, WE EXCLUDED NON-ENGLISH ARTICLES (22), EDITORIALS (20) AND LETTERS TO EDITOR (10). 37 STUDIES WERE CONSIDERED FOR THIS REVIEW. THE POSTULATED MECHANISM OF ACTION OF YOGA IS THROUGH PARASYMPATHETIC ACTIVATION AND THE ASSOCIATED ANTI STRESS MECHANISM. IT REDUCES PERCEIVED STRESS AND HPA AXIS ACTIVATION THEREBY IMPROVING OVERALL METABOLIC AND PSYCHOLOGICAL PROFILES, INCREASING INSULIN SENSITIVITY, AND IMPROVING GLUCOSE TOLERANCE AND LIPID METABOLISM. YOGA HAS POSITIVE EFFECTS ON IMMUNE SYSTEM OF DIABETICS.- OVERALL, TYPE II DM IS INFLUENCED BY PSYCHO-NEURO-ENDOCRINE AND IMMUNE MECHANISMS WHERE YOGA HAS IMPORTANT POSITIVE ROLE IN COMBATING STRESSORS AND IMPROVING THESE SYSTEMS TO REGAIN HEALTH.	2015	

6 1639 16 MODULATION OF IMMUNE RESPONSES IN STRESS BY YOGA. STRESS IS A CONSTANT FACTOR IN TODAY'S FASTPACED LIFE THAT CAN JEOPARDIZE OUR HEALTH IF LEFT UNCHECKED. IT IS ONLY IN THE LAST HALF CENTURY THAT THE ROLE OF STRESS IN EVERY AILMENT FROM THE COMMON COLD TO AIDS HAS BEEN EMPHASIZED, AND THE MECHANISMS INVOLVED IN THIS PROCESS HAVE BEEN STUDIED. STRESS INFLUENCES THE IMMUNE RESPONSE PRESUMABLY THROUGH THE ACTIVATION OF THE HYPOTHALAMIC-PITUITARY ADRENAL AXIS, HYPOTHALAMIC PITUITARY-GONADAL AXIS, AND THE SYMPATHETIC-ADRENAL-MEDULLARY SYSTEM. VARIOUS NEUROTRANSMITTERS, NEUROPEPTIDES, HORMONES, AND CYTOKINES MEDIATE THESE COMPLEX BIDIRECTIONAL INTERACTIONS BETWEEN THE CENTRAL NERVOUS SYSTEM (CNS) AND THE IMMUNE SYSTEM. THE EFFECTS OF STRESS ON THE IMMUNE RESPONSES RESULT IN ALTERATIONS IN THE NUMBER OF IMMUNE CELLS AND CYTOKINE DYSREGULATION. VARIOUS STRESS MANAGEMENT STRATEGIES SUCH AS MEDITATION, YOGA, HYPNOSIS, AND MUSCLE RELAXATION HAVE BEEN SHOWN TO REDUCE THE PSYCHOLOGICAL AND PHYSIOLOGICAL EFFECTS OF STRESS IN CANCERS AND HIV INFECTION. THIS REVIEW AIMS TO DISCUSS THE EFFECT OF STRESS ON THE IMMUNE SYSTEM AND EXAMINE HOW RELAXATION TECHNIQUES SUCH AS YOGA AND MEDITATION COULD REGULATE THE CYTOKINE LEVELS AND HENCE, THE IMMUNE RESPONSES DURING STRESS.	2008	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
7 2009 21 SUBJECTIVE SLEEP QUALITY AND HORMONAL MODULATION IN LONG-TERM YOGA PRACTITIONERS. YOGA REPRESENTS A FASCINATING MIND-BODY APPROACH, WHEREIN BODY MOVEMENTS (ASANA), BREATHING EXERCISES (PRANAYAMA) AND MEDITATION ARE INTEGRATED INTO A SINGLE MULTIDIMENSIONAL PRACTICE. NUMEROUS BENEFICIAL MENTAL AND PHYSICAL EFFECTS HAVE BEEN CLASSICALLY ASCRIBED TO THIS HOLISTIC ANCIENT METHOD. THE PURPOSE OF THE PRESENT STUDY HAS BEEN TO EXAMINE THE EFFECTS OF LONG-TERM YOGA PRACTICE ON SUBJECTIVE SLEEP QUALITY (SSQ) AND ON SEVERAL HORMONAL PARAMETERS OF THE HYPOTHALAMUS-PITUITARY-ADRENAL (HPA) AXIS. TWENTY-SIX SUBJECTS (16 EXPERIMENTAL AND 10 CONTROLS) WERE RECRUITED TO BE PART OF THE STUDY. EXPERIMENTAL SUBJECTS WERE REGULAR YOGA PRACTITIONERS WITH A MINIMUM OF 3 YEARS OF PRACTICE. BLOOD SAMPLES FOR THE QUANTIFICATION OF ADRENOCORTICOTROPIC HORMONE (ACTH), CORTISOL AND DEHYDROEPIANDROSTERONE SULPHATE (DHEA-S) WERE DRAWN FROM ALL SUBJECTS. LIKEWISE, THE PITTSBURGH SLEEP QUALITY INDEX (PSQI) WAS EMPLOYED TO ASSESS SSQ. AS STATISTICAL ANALYSIS, MANN-WHITNEY U-TEST WAS PERFORMED. THE YOGA GROUP DISPLAYED LOWER PSQI SCORES AND HIGHER BLOOD CORTISOL LEVELS THAN CONTROL SUBJECTS. THEREFORE, IT CAN BE CONCLUDED THAT LONG-TERM YOGA PRACTICE IS ASSOCIATED WITH SIGNIFICANT PSYCHO-BIOLOGICAL DIFFERENCES, INCLUDING BETTER SLEEP QUALITY AS WELL AS A MODULATORY ACTION ON THE LEVELS OF CORTISOL. THESE PRELIMINARY RESULTS SUGGEST INTERESTING CLINICAL IMPLICATIONS WHICH SHOULD BE FURTHER RESEARCHED.	2009	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
8 2743 17 YOGA PRACTICE IMPROVES EXECUTIVE FUNCTION BY ATTENUATING STRESS LEVELS. BACKGROUND: PROLONGED ACTIVATION OF THE HYPOTHALAMUS-PITUITARY-ADRENAL SYSTEM IS THOUGHT TO HAVE DELETERIOUS EFFECTS ON BRAIN FUNCTION. NEUROENDOCRINE STUDIES SUGGEST THAT BRAIN EXPOSURE TO HIGHER CORTISOL CONCENTRATIONS CONTRIBUTE TO COGNITIVE DEFICITS AS WE AGE. MIND-BODY TECHNIQUES SUCH AS YOGA HAVE SHOWN TO IMPROVE STRESS LEVELS BY RESTORING THE BODY'S SYMPATHETIC-PARASYMPATHETIC BALANCE. THE OBJECTIVE OF THIS STUDY WAS TO DETERMINE WHETHER YOGA PRACTICE MODERATED THE STRESS RESPONSE RESULTING IN IMPROVED EXECUTIVE FUNCTION. METHODS: SEDENTARY COMMUNITY DWELLING OLDER ADULTS (N=118, MEAN AGE=62.02) WERE RANDOMIZED TO AN 8-WEEK YOGA INTERVENTION OR A STRETCHING CONTROL GROUP. AT BASELINE AND FOLLOWING 8 WEEKS, ALL PARTICIPANTS COMPLETED MEASURES OF EXECUTIVE FUNCTION, SELF-REPORTED STRESS AND ANXIETY AND PROVIDED SALIVA SAMPLES BEFORE AND AFTER COGNITIVE TESTING TO ASSESS CORTISOL. RESULTS: YOGA PARTICIPANTS SHOWED IMPROVED ACCURACY ON EXECUTIVE FUNCTION MEASURES AND AN ATTENUATED CORTISOL RESPONSE COMPARED TO THEIR STRETCHING COUNTERPARTS WHO SHOWED INCREASED CORTISOL LEVELS AND POOR COGNITIVE PERFORMANCE AT FOLLOW UP. THE CHANGE IN CORTISOL LEVELS AS WELL AS SELF-REPORTED STRESS AND ANXIETY LEVELS PREDICTED PERFORMANCE ON THE RUNNING SPAN TASK, N-BACK WORKING MEMORY AND TASK SWITCHING PARADIGM (BETA'S=0.27-0.38, P'S</=0.05 FOR YOGA AND BETA'S=-0.37-0.47, P'S</=0.01 FOR STRETCHING CONTROL). CONCLUSION: EIGHT WEEKS OF REGULAR YOGA PRACTICE RESULTED IN IMPROVED WORKING MEMORY PERFORMANCE THAT WAS MEDIATED BY AN ATTENUATED RESPONSE TO STRESS AS MEASURED BY SELF-REPORT STRESS AND OBJECTIVE SALIVARY CORTISOL MEASUREMENTS. THIS TRIAL OFFERS EVIDENCE FOR NON-TRADITIONAL PHYSICAL ACTIVITY INTERVENTIONS SUCH AS YOGA THAT MAY BE HELPFUL IN RESTORING HPA BALANCE IN OLDER ADULTS, THEREBY PREVENTING COGNITIVE DECLINE.	2016	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
9  226 23 A SYSTEMATIC REVIEW OF RANDOMISED CONTROL TRIALS ON THE EFFECTS OF YOGA ON STRESS MEASURES AND MOOD. STRESS RELATED DISORDERS SUCH AS DEPRESSION AND ANXIETY ARE LEADING SOURCES OF DISABILITY WORLDWIDE, AND CURRENT TREATMENT METHODS SUCH AS CONVENTIONAL ANTIDEPRESSANT MEDICATIONS ARE NOT BENEFICIAL FOR ALL INDIVIDUALS. THERE IS EVIDENCE THAT YOGA HAS MOOD-ENHANCING PROPERTIES POSSIBLY RELATED TO ITS INHIBITORY EFFECTS ON PHYSIOLOGICAL STRESS AND INFLAMMATION, WHICH ARE FREQUENTLY ASSOCIATED WITH AFFECTIVE DISORDERS. HOWEVER THE BIOLOGICAL MECHANISMS VIA WHICH YOGA EXERTS ITS THERAPEUTIC MOOD-MODULATING EFFECTS ARE LARGELY UNKNOWN. THIS SYSTEMATIC REVIEW INVESTIGATES THE EFFECTS OF YOGA ON SYMPATHETIC NERVOUS SYSTEM AND HYPOTHALAMIC PITUITARY ADRENAL AXIS REGULATION MEASURES. IT FOCUSES ON STUDIES COLLECTING PHYSIOLOGICAL PARAMETERS SUCH AS BLOOD PRESSURE, HEART RATE, CORTISOL, PERIPHERAL CYTOKINE EXPRESSION AND/OR STRUCTURAL AND FUNCTIONAL BRAIN MEASURES IN REGIONS INVOLVED IN STRESS AND MOOD REGULATION. OVERALL THE 25 RANDOMISED CONTROL STUDIES DISCUSSED PROVIDE PRELIMINARY EVIDENCE TO SUGGEST THAT YOGA PRACTICE LEADS TO BETTER REGULATION OF THE SYMPATHETIC NERVOUS SYSTEM AND HYPOTHALAMIC-PITUITARY-ADRENAL SYSTEM, AS WELL AS A DECREASE IN DEPRESSIVE AND ANXIOUS SYMPTOMS IN A RANGE OF POPULATIONS. FURTHER RESEARCH IS WARRANTED TO CONFIRM THESE PRELIMINARY FINDINGS AND FACILITATE IMPLEMENTATION IN CLINICAL SETTINGS.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
10 2886 23 YOGA: BALANCING THE EXCITATION-INHIBITION EQUILIBRIUM IN PSYCHIATRIC DISORDERS. SOCIAL BEHAVIORAL DISTURBANCES ARE CENTRAL TO MOST PSYCHIATRIC DISORDERS. A DISEQUILIBRIUM WITHIN THE CORTICAL EXCITATORY AND INHIBITORY NEUROTRANSMITTER SYSTEMS UNDERLIES THESE DEFICITS. GAMMA-AMINOBUTYRIC ACID (GABA) AND GLUTAMATE ARE THE MOST ABUNDANT EXCITATORY AND INHIBITORY NEUROTRANSMITTERS IN THE BRAIN THAT CONTRIBUTE TO THIS EQUILIBRIUM. SEVERAL CONTEMPORARY THERAPIES USED IN TREATING PSYCHIATRIC DISORDERS, REGULATE THIS GABA-GLUTAMATE BALANCE. YOGA HAS BEEN STUDIED AS AN ADJUVANT TREATMENT ACROSS A BROAD RANGE OF PSYCHIATRIC DISORDERS AND IS SHOWN TO HAVE SHORT-TERM THERAPEUTIC GAINS. EMERGING EVIDENCE FROM RECENT CLINICAL IN VIVO EXPERIMENTS SUGGESTS THAT YOGA IMPROVES GABA-MEDIATED CORTICAL-INHIBITORY TONE AND ENHANCES PERIPHERAL OXYTOCIN LEVELS. THIS IS LIKELY TO HAVE A MORE CONTROLLED DOWNSTREAM RESPONSE OF THE HYPOTHALAMO-PITUITARY-ADRENAL SYSTEM BY MEANS OF REDUCED CORTISOL RELEASE AND HENCE A BLUNTED SYMPATHETIC RESPONSE TO STRESS. ANIMAL AND EARLY FETAL DEVELOPMENTAL STUDIES SUGGEST AN INTER-DEPENDENT ROLE OF OXYTOCIN AND GABA IN REGULATING SOCIAL BEHAVIORS. IN KEEPING WITH THESE OBSERVATIONS, WE PROPOSE AN INTEGRATED NEUROBIOLOGICAL MODEL TO STUDY THE MECHANISMS OF THERAPEUTIC BENEFITS WITH YOGA. APART FROM PROVIDING A NEUROSCIENTIFIC BASIS FOR APPLYING A TRADITIONAL SYSTEM OF PRACTICE IN THE CLINICAL SETTING, THIS MODEL CAN BE USED AS A FRAMEWORK FOR STUDYING YOGA MECHANISMS IN FUTURE CLINICAL TRIALS.	2019	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
11 2210 20 THE HEALTH BENEFITS OF YOGA AND EXERCISE: A REVIEW OF COMPARISON STUDIES. OBJECTIVES: EXERCISE IS CONSIDERED AN ACCEPTABLE METHOD FOR IMPROVING AND MAINTAINING PHYSICAL AND EMOTIONAL HEALTH. A GROWING BODY OF EVIDENCE SUPPORTS THE BELIEF THAT YOGA BENEFITS PHYSICAL AND MENTAL HEALTH VIA DOWN-REGULATION OF THE HYPOTHALAMIC-PITUITARY-ADRENAL (HPA) AXIS AND THE SYMPATHETIC NERVOUS SYSTEM (SNS). THE PURPOSE OF THIS ARTICLE IS TO PROVIDE A SCHOLARLY REVIEW OF THE LITERATURE REGARDING RESEARCH STUDIES COMPARING THE EFFECTS OF YOGA AND EXERCISE ON A VARIETY OF HEALTH OUTCOMES AND HEALTH CONDITIONS. METHODS: USING PUBMED((R)) AND THE KEY WORD "YOGA," A COMPREHENSIVE SEARCH OF THE RESEARCH LITERATURE FROM CORE SCIENTIFIC AND NURSING JOURNALS YIELDED 81 STUDIES THAT MET INCLUSION CRITERIA. THESE STUDIES SUBSEQUENTLY WERE CLASSIFIED AS UNCONTROLLED (N = 30), WAIT LIST CONTROLLED (N = 16), OR COMPARISON (N = 35). THE MOST COMMON COMPARISON INTERVENTION (N = 10) INVOLVED EXERCISE. THESE STUDIES WERE INCLUDED IN THIS REVIEW. RESULTS: IN THE STUDIES REVIEWED, YOGA INTERVENTIONS APPEARED TO BE EQUAL OR SUPERIOR TO EXERCISE IN NEARLY EVERY OUTCOME MEASURED EXCEPT THOSE INVOLVING PHYSICAL FITNESS. CONCLUSIONS: THE STUDIES COMPARING THE EFFECTS OF YOGA AND EXERCISE SEEM TO INDICATE THAT, IN BOTH HEALTHY AND DISEASED POPULATIONS, YOGA MAY BE AS EFFECTIVE AS OR BETTER THAN EXERCISE AT IMPROVING A VARIETY OF HEALTH-RELATED OUTCOME MEASURES. FUTURE CLINICAL TRIALS ARE NEEDED TO EXAMINE THE DISTINCTIONS BETWEEN EXERCISE AND YOGA, PARTICULARLY HOW THE TWO MODALITIES MAY DIFFER IN THEIR EFFECTS ON THE SNS/HPA AXIS. ADDITIONAL STUDIES USING RIGOROUS METHODOLOGIES ARE NEEDED TO EXAMINE THE HEALTH BENEFITS OF THE VARIOUS TYPES OF YOGA.	2010	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
12 1089 19 EFFECTS OF YOGA ON THE AUTONOMIC NERVOUS SYSTEM, GAMMA-AMINOBUTYRIC-ACID, AND ALLOSTASIS IN EPILEPSY, DEPRESSION, AND POST-TRAUMATIC STRESS DISORDER. A THEORY IS PROPOSED TO EXPLAIN THE BENEFITS OF YOGA PRACTICES IN DIVERSE, FREQUENTLY COMORBID MEDICAL CONDITIONS BASED ON THE CONCEPT THAT YOGA PRACTICES REDUCE ALLOSTATIC LOAD IN STRESS RESPONSE SYSTEMS SUCH THAT OPTIMAL HOMEOSTASIS IS RESTORED. IT IS HYPOTHESIZED THAT STRESS INDUCES (1) IMBALANCE OF THE AUTONOMIC NERVOUS SYSTEM (ANS) WITH DECREASED PARASYMPATHETIC NERVOUS SYSTEM (PNS) AND INCREASED SYMPATHETIC NERVOUS SYSTEM (SNS) ACTIVITY, (2) UNDERACTIVITY OF THE GAMMA AMINO-BUTYRIC ACID (GABA) SYSTEM, THE PRIMARY INHIBITORY NEUROTRANSMITTER SYSTEM, AND (3) INCREASED ALLOSTATIC LOAD. IT IS FURTHER HYPOTHESIZED THAT YOGA-BASED PRACTICES (4) CORRECT UNDERACTIVITY OF THE PNS AND GABA SYSTEMS IN PART THROUGH STIMULATION OF THE VAGUS NERVES, THE MAIN PERIPHERAL PATHWAY OF THE PNS, AND (5) REDUCE ALLOSTATIC LOAD. DEPRESSION, EPILEPSY, POST TRAUMATIC STRESS DISORDER (PTSD), AND CHRONIC PAIN EXEMPLIFY MEDICAL CONDITIONS THAT ARE EXACERBATED BY STRESS, HAVE LOW HEART RATE VARIABILITY (HRV) AND LOW GABAERGIC ACTIVITY, RESPOND TO PHARMACOLOGIC AGENTS THAT INCREASE ACTIVITY OF THE GABA SYSTEM, AND SHOW SYMPTOM IMPROVEMENT IN RESPONSE TO YOGA-BASED INTERVENTIONS. THE OBSERVATION THAT TREATMENT RESISTANT CASES OF EPILEPSY AND DEPRESSION RESPOND TO VAGAL NERVE STIMULATION CORROBORATES THE NEED TO CORRECT PNS UNDERACTIVITY AS PART OF A SUCCESSFUL TREATMENT PLAN IN SOME CASES. ACCORDING TO THE PROPOSED THEORY, THE DECREASED PNS AND GABAERGIC ACTIVITY THAT UNDERLIES STRESS-RELATED DISORDERS CAN BE CORRECTED BY YOGA PRACTICES RESULTING IN AMELIORATION OF DISEASE SYMPTOMS. THIS HAS FAR-REACHING IMPLICATIONS FOR THE INTEGRATION OF YOGA-BASED PRACTICES IN THE TREATMENT OF A BROAD ARRAY OF DISORDERS EXACERBATED BY STRESS.	2012	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
13  588 25 DETERMINING PSYCHONEUROIMMUNOLOGIC MARKERS OF YOGA AS AN INTERVENTION FOR PERSONS DIAGNOSED WITH PTSD: A SYSTEMATIC REVIEW. THERE IS A GROWING BODY OF RESEARCH ON YOGA AS A THERAPEUTIC INTERVENTION FOR PSYCHOLOGICAL SYMPTOMS OF POST-TRAUMATIC STRESS DISORDER (PTSD) ACCOMPANIED BY SPECULATIONS ON UNDERLYING PHYSIOLOGIC MECHANISMS. THE PURPOSE OF THIS SYSTEMATIC REVIEW IS TO IDENTIFY, QUALITATIVELY EVALUATE, AND SYNTHESIZE STUDIES OF YOGA AS AN INTERVENTION FOR PTSD THAT MEASURED PHYSIOLOGIC OUTCOMES IN ORDER TO GAIN INSIGHTS INTO POTENTIAL MECHANISMS. THE FOCUS IS ON STUDIES EVALUATING YOGA AS A THERAPEUTIC INTERVENTION FOR PTSD RATHER THAN FOR TRAUMA EXPOSURE, PTSD PREVENTION, OR SUBCLINICAL PTSD. MULTIPLE DATABASES WERE SEARCHED FOR PUBLICATIONS FROM THE PAST TWO DECADES USING TERMS DERIVED FROM THE QUESTION, "IN PEOPLE WITH PTSD, WHAT IS THE EFFECT OF YOGA ON OBJECTIVE OUTCOMES?" ELIGIBILITY CRITERIA INCLUDED YOGA-ONLY MODALITIES TESTED AS AN INTERVENTION FOR FORMALLY DIAGNOSED PTSD WITH AT LEAST ONE PHYSIOLOGIC OUTCOME. RESULTS OF THIS REVIEW CONFIRMED THAT, THOUGH MUCH OF THE PUBLISHED LITERATURE PROPOSES PHYSIOLOGICAL MECHANISMS UNDERLYING YOGA'S EFFECTS ON PTSD, VERY FEW STUDIES ( N = 3) HAVE ACTUALLY EVALUATED PHYSIOLOGICAL EVIDENCE. ADDITIONALLY, SEVERAL STUDIES HAD METHODOLOGICAL LIMITATIONS. IN LIGHT OF THE LIMITED DATA SUPPORTING YOGA'S BENEFICIAL EFFECTS ON AUTONOMIC NERVOUS SYSTEM DYSREGULATION, WE PRESENT A THEORETICAL MODEL OF THE PSYCHONEUROIMMUNOLOGIC PROCESSES ASSOCIATED WITH PTSD AND THE EFFECTS YOGA MAY HAVE ON THESE PROCESSES TO GUIDE FUTURE RESEARCH. GAPS IN THE LITERATURE REMAIN FOR MECHANISMS RELATED TO ACTIVATION OF THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS AND INFLAMMATION. ADDITIONAL RIGOROUS MECHANISTIC STUDIES ARE NEEDED TO GUIDE DEVELOPMENT OF EFFECTIVE YOGA INTERVENTIONS FOR PTSD TO AUGMENT EXISTING EVIDENCE-BASED PTSD TREATMENTS.	2018	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
14 1337 21 HOW DOES YOGA REDUCE STRESS? A SYSTEMATIC REVIEW OF MECHANISMS OF CHANGE AND GUIDE TO FUTURE INQUIRY. YOGA IS INCREASINGLY USED IN CLINICAL SETTINGS FOR A VARIETY OF MENTAL AND PHYSICAL HEALTH ISSUES, PARTICULARLY STRESS-RELATED ILLNESSES AND CONCERNS, AND HAS DEMONSTRATED PROMISING EFFICACY. YET THE WAYS IN WHICH YOGA REDUCES STRESS REMAIN POORLY UNDERSTOOD. TO EXAMINE THE EMPIRICAL EVIDENCE REGARDING THE MECHANISMS THROUGH WHICH YOGA REDUCES STRESS, WE CONDUCTED A SYSTEMATIC REVIEW OF THE LITERATURE, INCLUDING ANY YOGA INTERVENTION THAT MEASURED STRESS AS A PRIMARY DEPENDENT VARIABLE AND TESTED A MECHANISM OF THE RELATIONSHIP WITH MEDIATION. OUR ELECTRONIC DATABASE SEARCH YIELDED 926 ABSTRACTS, OF WHICH 71 WERE CHOSEN FOR FURTHER INSPECTION AND 5 WERE SELECTED FOR THE FINAL SYSTEMATIC REVIEW. THESE FIVE STUDIES EXAMINED THREE PSYCHOLOGICAL MECHANISMS (POSITIVE AFFECT, MINDFULNESS AND SELF-COMPASSION) AND FOUR BIOLOGICAL MECHANISMS (POSTERIOR HYPOTHALAMUS, INTERLEUKIN-6, C-REACTIVE PROTEIN AND CORTISOL). POSITIVE AFFECT, SELF-COMPASSION, INHIBITION OF THE POSTERIOR HYPOTHALAMUS AND SALIVARY CORTISOL WERE ALL SHOWN TO MEDIATE THE RELATIONSHIP BETWEEN YOGA AND STRESS. IT IS STRIKING THAT THE LITERATURE DESCRIBING POTENTIAL MECHANISMS IS GROWING RAPIDLY, YET ONLY SEVEN MECHANISMS HAVE BEEN EMPIRICALLY EXAMINED; MORE RESEARCH IS NECESSARY. ALSO, FUTURE RESEARCH OUGHT TO INCLUDE MORE RIGOROUS METHODOLOGY, INCLUDING SUFFICIENT POWER, STUDY RANDOMISATION AND APPROPRIATE CONTROL GROUPS.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
15 2776 21 YOGA SCHOOL OF THOUGHT AND PSYCHIATRY: THERAPEUTIC POTENTIAL. YOGA IS A TRADITIONAL LIFE-STYLE PRACTICE USED FOR SPIRITUAL REASONS. HOWEVER, THE PHYSICAL COMPONENTS LIKE THE ASANAS AND PRANAYAAMAS HAVE DEMONSTRATED PHYSIOLOGICAL AND THERAPEUTIC EFFECTS. THERE IS EVIDENCE FOR YOGA AS BEING A POTENT ANTIDEPRESSANT THAT MATCHES WITH DRUGS. IN DEPRESSIVE DISORDER, YOGA 'CORRECTS' AN UNDERLYING COGNITIVE PHYSIOLOGY. IN SCHIZOPHRENIA PATIENTS, YOGA HAS BENEFITS AS AN ADD-ON INTERVENTION IN PHARMACOLOGICALLY STABILIZED SUBJECTS. THE EFFECTS ARE PARTICULARLY NOTABLE ON NEGATIVE SYMPTOMS. YOGA ALSO HELPS TO CORRECT SOCIAL COGNITION. YOGA CAN BE INTRODUCED EARLY IN THE TREATMENT OF PSYCHOSIS WITH SOME BENEFITS. ELEVATION OF OXYTOCIN MAY BE A MECHANISM OF YOGA EFFECTS IN SCHIZOPHRENIA. CERTAIN COMPONENTS OF YOGA HAVE DEMONSTRATED NEUROBIOLOGICAL EFFECTS SIMILAR TO THOSE OF VAGAL STIMULATION, INDICATING THIS (INDIRECT OR AUTOGENOUS VAGAL STIMULATION) AS A POSSIBLE MECHANISM OF ITS ACTION. IT IS TIME, PSYCHIATRISTS EXPLOITED THE BENEFITS IF YOGA FOR A COMPREHENSIVE CARE IN THEIR PATIENTS.	2013	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
16 1347 16 HYPOXIA IN CNS PATHOLOGIES: EMERGING ROLE OF MIRNA-BASED NEUROTHERAPEUTICS AND YOGA BASED ALTERNATIVE THERAPIES. CELLULAR RESPIRATION IS A VITAL PROCESS FOR THE EXISTENCE OF LIFE. ANY CONDITION THAT RESULTS IN DEPRIVATION OF OXYGEN (ALSO TERMED AS HYPOXIA) MAY EVENTUALLY LEAD TO DELETERIOUS EFFECTS ON THE FUNCTIONING OF TISSUES. BRAIN BEING THE HIGHEST CONSUMER OF OXYGEN IS PRONE TO INCREASED RISK OF HYPOXIA-INDUCED NEUROLOGICAL INSULTS. THIS IN TURN HAS BEEN ASSOCIATED WITH MANY DISEASES OF CENTRAL NERVOUS SYSTEM (CNS) SUCH AS STROKE, ALZHEIMER'S, ENCEPHALOPATHY ETC. ALTHOUGH SEVERAL STUDIES HAVE INVESTIGATED THE PATHOPHYSIOLOGICAL MECHANISMS UNDERLYING ISCHEMIC/HYPOXIC CNS DISEASES, THE KNOWLEDGE ABOUT PROTECTIVE THERAPEUTIC STRATEGIES TO AMELIORATE THE AFFECTED NEURONAL CELLS IS MEAGER. THIS HAS AUGMENTED THE NEED TO IMPROVE OUR UNDERSTANDING OF THE HYPOXIC AND ISCHEMIC EVENTS OCCURRING IN THE BRAIN AND IDENTIFY NOVEL AND ALTERNATE TREATMENT MODALITIES FOR SUCH INSULTS. MICRORNA (MIRNAS), SMALL NON-CODING RNA MOLECULES, HAVE RECENTLY EMERGED AS POTENTIAL NEUROPROTECTIVE AGENTS AS WELL AS TARGETS, UNDER HYPOXIC CONDITIONS. THESE 18-22 NUCLEOTIDE LONG RNA MOLECULES ARE PROFUSELY PRESENT IN BRAIN AND OTHER ORGANS AND FUNCTION AS GENE REGULATORS BY CLEAVING AND SILENCING THE GENE EXPRESSION. IN BRAIN, THESE ARE KNOWN TO BE INVOLVED IN NEURONAL DIFFERENTIATION AND PLASTICITY. THEREFORE, TARGETING MIRNA EXPRESSION REPRESENTS A NOVEL THERAPEUTIC APPROACH TO INTERCEDE AGAINST HYPOXIC AND ISCHEMIC BRAIN INJURY. IN THE FIRST PART OF THIS REVIEW, WE WILL DISCUSS THE NEUROPHYSIOLOGICAL CHANGES CAUSED AS A RESULT OF HYPOXIA, FOLLOWED BY THE CONTRIBUTION OF HYPOXIA IN THE NEURODEGENERATIVE DISEASES. SECONDLY, WE WILL PROVIDE RECENT UPDATES AND INSIGHTS INTO THE ROLES OF MIRNA IN THE REGULATION OF GENES IN OXYGEN AND GLUCOSE DEPRIVED BRAIN IN ASSOCIATION WITH CIRCADIAN RHYTHMS AND HOW THESE CAN BE TARGETED AS NEUROPROTECTIVE AGENTS FOR CNS INJURIES. FINALLY, WE WILL EMPHASIZE ON ALTERNATE BREATHING OR YOGIC INTERVENTIONS TO OVERCOME THE HYPOXIA ASSOCIATED ANOMALIES THAT COULD ULTIMATELY LEAD TO IMPROVEMENT IN CEREBRAL PERFUSION.	2017	
                                                                                                                                                                                                                                                                                                                                                                                                  
17 2516 15 YOGA CLINICAL RESEARCH REVIEW. IN THIS PAPER RECENT RESEARCH IS REVIEWED ON THE EFFECTS OF YOGA POSES ON PSYCHOLOGICAL CONDITIONS INCLUDING ANXIETY AND DEPRESSION, ON PAIN SYNDROMES, CARDIOVASCULAR, AUTOIMMUNE AND IMMUNE CONDITIONS AND ON PREGNANCY. FURTHER, THE PHYSIOLOGICAL EFFECTS OF YOGA INCLUDING DECREASED HEARTRATE AND BLOOD PRESSURE AND THE PHYSICAL EFFECTS INCLUDING WEIGHT LOSS AND INCREASED MUSCLE STRENGTH ARE REVIEWED. FINALLY, POTENTIAL UNDERLYING MECHANISMS ARE PROPOSED INCLUDING THE STIMULATION OF PRESSURE RECEPTORS LEADING TO ENHANCED VAGAL ACTIVITY AND REDUCED CORTISOL. THE REDUCTION IN CORTISOL, IN TURN, MAY CONTRIBUTE TO POSITIVE EFFECTS SUCH AS ENHANCED IMMUNE FUNCTION AND A LOWER PREMATURITY RATE.	2011	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
18 2436 18 YOGA AND PSYCHIATRIC DISORDERS: A REVIEW OF BIOMARKER EVIDENCE. TRADITIONALLY, YOGA HAS BEEN USED AS A MEANS FOR SPIRITUAL GROWTH BUT OVER THE PAST TWO DECADES OR SO ITS THERAPEUTIC BENEFITS IN PSYCHIATRIC DISORDERS HAVE BEEN SCIENTIFICALLY EXPLORED. YOGA HAS BEEN SHOWN TO BE USEFUL AS A MONO-THERAPY IN MILD TO MODERATE DEPRESSION AND AS AN ADJUVANT IN SEVERAL PSYCHIATRIC DISORDERS INCLUDING SCHIZOPHRENIA, ANXIETY DISORDERS, SUBSTANCE USE DISORDERS AND MILD COGNITIVE IMPAIRMENT. FURTHERMORE, SYSTEMATIC ATTEMPTS HAVE BEEN MADE TO UNDERSTAND THE BIOLOGICAL CORRELATES OF YOGA IN THESE PSYCHIATRIC DISORDERS. GIVEN THAT NO PSYCHIATRIC DISORDER HAS STRONG AND ESTABLISHED BIOMARKERS, IT IS INTERESTING THAT PRELIMINARY RESEARCH HAS DEMONSTRATED SIGNIFICANT CHANGES IN CERTAIN IMPORTANT BIOMARKERS FOLLOWING REGULAR YOGA PRACTICE. IN THIS BRIEF REVIEW, WE PROVIDE AN UPDATE ON THE EFFECTS OF YOGA ON BIOCHEMICAL, NEURO-PHYSIOLOGICAL AND NEURO-IMAGING RELATED BIO-MARKERS IN PSYCHIATRIC DISORDERS. ALTHOUGH FINDINGS AND TRENDS ARE PROMISING, MUCH MORE RESEARCH IS WARRANTED TO ESTABLISH A DEFINITE BIOLOGICAL BASIS FOR YOGA IN PSYCHIATRY.	2021	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
19 1581 22 MECHANISM OF ACTION OF YOGA ON PREVENTION AND MANAGEMENT OF TYPE 2 DIABETES MELLITUS: NARRATIVE REVIEW. BACKGROUND: RESEARCH IN INDIA HAS RECOGNIZED TYPE 2 DIABETES MELLITUS (T2DM) AND PREDIABETES (PDM) AS PSYCHOSOMATIC METABOLIC ENDOCRINE DISORDERS CHARACTERIZED BY GLYCEMIC DISHARMONY. THIS REVIEW AIMED AT COLLATING INFORMATION FROM PUBLISHED E-PAPERS ON MECHANISM OF ACTION (MOA) OF YOGA THERAPY(YT) AND INTEGRATED APPROACH OF YOGA THERAPY (IAYT) ON PDM AND T2DM. METHOD: CONTENT ON YT AND THE MOA ON PREVENTION AND MANAGEMENT OF T2DM WERE EXTRACTED FROM ONLINE SOURCES SUCH AS PUBMED, GOOGLE SCHOLAR, COCHRANE LIBRARY AND LIBRARY GENESIS. THIS REVIEW INCLUDED 58 ARTICLES RELATED TO PREDIABETES, T2DM, PRE-DIABETES TO T2DM CONVERSION, MECHANISM OF ACTION OF YOGA, YOGA AND T2DM, PREDIABETES AND YOGA. ARTICLES RELATED TO TYPE 1 DIABETES, DIABETES INSIPIDUS AND GESTATIONAL DIABETES WERE EXCLUDED. RESULT: CURRENT SCIENTIFIC REVIEW RESULTED IN UNDERSTANDING THE DIFFERENT MECHANISMS INVOLVED IN REJUVENATING EFFECT OF YOGA AS YT AND IAYT IN PREDIABETES AND T2DM. HOWEVER, THE VARIOUS MECHANISMS BY WHICH THE INTERVENTIONS WORK ARE UNDERSTOOD EITHER THROUGH A SINGLE OR COMBINED IMPACT ON REGAINING AUTONOMIC BALANCE, VAGAL MODULATION, REGULATION OF HORMONES AND THEREBY ATTAINING GLYCEMIC CONTROL. MOREOVER, THESE MECHANISMS ARE THE FORTHCOMINGS OF THE CROSS TALK BETWEEN BRAIN, MIND AND BODY SYSTEMS UNDER BRANCHES OF NEUROPHYSIOLOGY, NEUROENDOCRINOLOGY, PSYCHOPHYSIOLOGY, PSYCHO NEUROENDOCRINOLOGY AND/OR NEUROPSYCHOLOGY. CONCLUSION: EVIDENCE SOUGHT FROM PUBLISHED RESEARCH WORKS PROCLAIM YT BASED LIFE STYLE MODIFICATION FOR PREVENTION AND MANAGEMENT OF T2DM. SUMMING UP, THE EFFECT IS STIPULATED BASED ON THE APPROACH, METHOD OF PRACTICE, TIME OF THE DAY, BELIEF AND DEDICATION OF THE PRACTITIONERS.	2022	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
20 1882 19 REDUCING ALLOSTATIC LOAD IN DEPRESSION AND ANXIETY DISORDERS: PHYSICAL ACTIVITY AND YOGA PRACTICE AS ADD-ON THERAPIES. THE ALLOSTATIC LOAD (AL) INDEX CONSTITUTES A USEFUL TOOL TO OBJECTIVELY ASSESS THE BIOLOGICAL ASPECTS OF CHRONIC STRESS IN CLINICAL PRACTICE. AL INDEX HAS BEEN POSITIVELY CORRELATED WITH CUMULATIVE CHRONIC STRESS (PHYSICAL AND PSYCHOSOCIAL STRESSORS) AND WITH A HIGH RISK TO DEVELOP PATHOLOGICAL CONDITIONS (E.G., METABOLIC SYNDROME, CARDIOVASCULAR PATHOLOGY, INFLAMMATORY DISORDERS) AND THE SO-CALLED STRESS-RELATED PSYCHIATRIC DISORDERS, INCLUDING ANXIETY AND DEPRESSIVE DISORDERS. CHRONIC STRESS HAS NEGATIVE EFFECTS ON BRAIN NEUROPLASTICITY, ESPECIALLY ON HIPPOCAMPAL NEUROGENESIS AND THESE EFFECTS MAY BE REVERSED BY ANTIDEPRESSANT TREATMENTS. SEVERAL EVIDENCES INDICATE THAT NON-PHARMACOLOGICAL INTERVENTIONS BASED ON PHYSICAL ACTIVITY AND YOGA PRACTICE MAY ADD SYNERGIZING BENEFITS TO CLASSICAL TREATMENTS (ANTIDEPRESSANT AND BENZODIAZEPINES) FOR DEPRESSION AND ANXIETY, REDUCING THE NEGATIVE EFFECTS OF CHRONIC STRESS. THE AIM OF THIS REVIEW IS TO PROVIDE A GENERAL OVERVIEW OF CURRENT KNOWLEDGE ON AL AND CHRONIC STRESS IN RELATION TO DEPRESSION AND ANXIETY, PHYSICAL ACTIVITY AND YOGA PRACTICE.	2020