1 1634 163 MODELING THE EFFECTS OF YOGA ON THE PROGRESSION OF ALZHEIMER'S DISEASE IN A DISH. ALZHEIMER'S DISEASE (AD) ACCOUNTS FOR 80% OF ALL DEMENTIA CASES, MAKING IT THE MOST COMMON FORM OF DEMENTIA. AGING SERVES AS THE MAIN RISK FACTOR FOR AD, BUT EARLY ONSET AD CAN ALSO OCCUR IN INDIVIDUALS YOUNGER THAN 65 YEARS. AD RESULTS FROM PROGRESSIVE NEURODEGENERATION LEADING TO DYSFUNCTIONAL SYNAPTIC TRANSMISSION IN THE BRAIN. THE CASCADE HYPOTHESIS OF AD STATES THAT AMYLOID PRECURSOR PROTEIN (APP) METABOLISM BECOMES IMPAIRED EITHER BY MUTATION OR AN INTERLEUKIN-MEDIATED STRESS RESPONSE TO INJURY, RESULTING IN THE SPLICING OF HARMFUL OLIGOMERIC FORMS OF AMYLOID BETA (ABETA). THESE OLIGOMERS DISRUPT EXTRACELLULAR RECEPTOR BINDING, INTRACELLULAR FUNCTION, AND CELLULAR MEMBRANE INTEGRITY. YOGA AND MEDITATIVE PRACTICES SLOW THE PROGRESSION OF THE COGNITIVE DECLINE ASSOCIATED WITH AD. HOWEVER, THE BIOLOGICAL MECHANISMS UNDERLYING THIS THERAPEUTIC EFFECT REMAIN ELUSIVE. HERE, WE INVESTIGATED THE ABILITY OF NEUROTRANSMITTERS RELEASED DURING YOGA AND MEDITATIVE PRACTICES TO RESCUE NEURONS FROM SYNAPTIC DYSFUNCTION IN AN IN VITRO ALZHEIMER'S MODEL CREATED BY CULTURING BASAL FOREBRAIN CHOLINERGIC NEURONS WITH PHYSIOLOGICALLY RELEVANT LEVELS OF THE I-42 ISOFORM OF OLIGOMERIC ABETA (OALPHABETAI-42). WE FOUND THAT THE NEUROTRANSMITTERS DOPAMINE AND HISTAMINE PRODUCE A COOPERATIVE ACTION WITH SEROTONIN TO REVERSE THE LOSS OF CHOLINE ACETYLTRANSFERASE (CHAT) BY OALPHABETAI-42. THE LOSS OF CHAT, THE ENZYME RESPONSIBLE FOR PROCESSING THE CHOLINERGIC NEUROTRANSMITTER ACETYLCHOLINE, CONTRIBUTES TO THE SYNAPTIC DYSFUNCTION EXPERIENCED DURING AD. THESE NEUROTRANSMITTERS INHIBIT NITRIC OXIDE SYNTHESIS CAUSED BY OALPHABETAI-42, PREVENTING OXIDATIVE AND NITROSATIVE STRESS. SEROTONIN ACTIVATES AN ALTERNATE CLEAVAGE OF APP TO PRODUCE A FRAGMENT WITH KNOWN NEUROTROPHIC EFFECTS, GIVING IT THE UNIQUE ABILITY TO INHIBIT THE OALPHABETAI-42 PRODUCTION CYCLE. WE HYPOTHESIZE HERE THAT THESE CONCERTED ACTIONS LEAD TO THE PROTECTION OF CHOLINERGIC SYNAPTIC TRANSMISSION IN AD. 2018 2 787 19 EFFECT OF YOGA BREATHING EXERCISES (PRANAYAMA) ON AIRWAY REACTIVITY IN SUBJECTS WITH ASTHMA. THE EFFECTS OF TWO PRANAYAMA YOGA BREATHING EXERCISES ON AIRWAY REACTIVITY, AIRWAY CALIBRE, SYMPTOM SCORES, AND MEDICATION USE IN PATIENTS WITH MILD ASTHMA WERE ASSESSED IN A RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED, CROSSOVER TRIAL. AFTER BASELINE ASSESSMENT OVER 1 WEEK, 18 PATIENTS WITH MILD ASTHMA PRACTISED SLOW DEEP BREATHING FOR 15 MIN TWICE A DAY FOR TWO CONSECUTIVE 2-WEEK PERIODS. DURING THE ACTIVE PERIOD, SUBJECTS WERE ASKED TO BREATHE THROUGH A PINK CITY LUNG (PCL) EXERCISER--A DEVICE WHICH IMPOSES SLOWING OF BREATHING AND A 1:2 INSPIRATION:EXPIRATION DURATION RATIO EQUIVALENT TO PRANAYAMA BREATHING METHODS; DURING THE CONTROL PERIOD, SUBJECTS BREATHED THROUGH A MATCHED PLACEBO DEVICE. MEAN FORCED EXPIRATORY VOLUME IN 1 S (FEV1), PEAK EXPIRATORY FLOW RATE, SYMPTOM SCORE, AND INHALER USE OVER THE LAST 3 DAYS OF EACH TREATMENT PERIOD WERE ASSESSED IN COMPARISON WITH THE BASELINE ASSESSMENT PERIOD; ALL IMPROVED MORE WITH THE PCL EXERCISER THAN WITH THE PLACEBO DEVICE, BUT THE DIFFERENCES WERE NOT SIGNIFICANT. THERE WAS A STATISTICALLY SIGNIFICANT INCREASE IN THE DOSE OF HISTAMINE NEEDED TO PROVOKE A 20% REDUCTION IN FEV1 (PD20) DURING PRANAYAMA BREATHING BUT NOT WITH THE PLACEBO DEVICE. THE USEFULNESS OF CONTROLLED VENTILATION EXERCISES IN THE CONTROL OF ASTHMA SHOULD BE FURTHER INVESTIGATED. 1990 3 2545 18 YOGA FOR ASTHMA? A SYSTEMATIC REVIEW OF RANDOMIZED CLINICAL TRIALS. OBJECTIVE: THE OBJECTIVE OF THIS SYSTEMATIC REVIEW WAS TO ASSESS THE EFFECTIVENESS OF YOGA AS A TREATMENT OPTION FOR ASTHMA. METHOD: SEVEN DATABASES WERE SEARCHED FROM THEIR INCEPTION TO OCTOBER 2010. RANDOMIZED CLINICAL TRIALS (RCTS) AND NON-RANDOMIZED CLINICAL TRIALS (NRCTS) WERE CONSIDERED, IF THEY INVESTIGATED ANY TYPE OF YOGA IN PATIENTS WITH ASTHMA. THE SELECTION OF STUDIES, DATA EXTRACTION, AND VALIDATION WERE PERFORMED INDEPENDENTLY BY TWO REVIEWERS. RESULTS: SIX RCTS AND ONE NRCT MET THE INCLUSION CRITERIA. THEIR METHODOLOGICAL QUALITY WAS MOSTLY POOR. THREE RCTS AND ONE NRCT SUGGESTED THAT YOGA LEADS TO A SIGNIFICANTLY GREATER REDUCTION IN SPIROMETRIC MEASURES, AIRWAY HYPERRESPONSIVITY, DOSE OF HISTAMINE NEEDED TO PROVOKE A 20% REDUCTION IN FORCED EXPIRATORY VOLUME IN THE FIRST SECOND, WEEKLY NUMBER OF ASTHMA ATTACKS, AND NEED FOR DRUG TREATMENT. THREE RCTS SHOWED NO POSITIVE EFFECTS COMPARED TO VARIOUS CONTROL INTERVENTIONS. CONCLUSIONS: THE BELIEF THAT YOGA ALLEVIATES ASTHMA IS NOT SUPPORTED BY SOUND EVIDENCE. FURTHER, MORE RIGOROUS TRIALS ARE WARRANTED. 2011 4 865 21 EFFECT OF YOGA PRACTICES ON PULMONARY FUNCTION TESTS INCLUDING TRANSFER FACTOR OF LUNG FOR CARBON MONOXIDE (TLCO) IN ASTHMA PATIENTS. PRANA IS THE ENERGY, WHEN THE SELF-ENERGIZING FORCE EMBRACES THE BODY WITH EXTENSION AND EXPANSION AND CONTROL, IT IS PRANAYAMA. IT MAY AFFECT THE MILIEU AT THE BRONCHIOLES AND THE ALVEOLI PARTICULARLY AT THE ALVEOLO-CAPILLARY MEMBRANE TO FACILITATE DIFFUSION AND TRANSPORT OF GASES. IT MAY ALSO INCREASE OXYGENATION AT TISSUE LEVEL. AIM OF OUR STUDY IS TO COMPARE PULMONARY FUNCTIONS AND DIFFUSION CAPACITY IN PATIENTS OF BRONCHIAL ASTHMA BEFORE AND AFTER YOGIC INTERVENTION OF 2 MONTHS. SIXTY STABLE ASTHMATIC-PATIENTS WERE RANDOMIZED INTO TWO GROUPS I.E GROUP 1 (YOGA TRAINING GROUP) AND GROUP 2 (CONTROL GROUP). EACH GROUP INCLUDED THIRTY PATIENTS. LUNG FUNCTIONS WERE RECORDED ON ALL PATIENTS AT BASELINE, AND THEN AFTER TWO MONTHS. GROUP 1 SUBJECTS SHOWED A STATISTICALLY SIGNIFICANT IMPROVEMENT (P<0.001) IN TRANSFER FACTOR OF THE LUNG FOR CARBON MONOXIDE (TLCO), FORCED VITAL CAPACITY (FVC), FORCED EXPIRATORY VOLUME IN 1ST SEC (FEV1), PEAK EXPIRATORY FLOW RATE (PEFR), MAXIMUM VOLUNTARY VENTILATION (MVV) AND SLOW VITAL CAPACITY (SVC) AFTER YOGA PRACTICE. QUALITY OF LIFE ALSO INCREASED SIGNIFICANTLY. IT WAS CONCLUDED THAT PRANAYAMA & YOGA BREATHING AND STRETCHING POSTURES ARE USED TO INCREASE RESPIRATORY STAMINA, RELAX THE CHEST MUSCLES, EXPAND THE LUNGS, RAISE ENERGY LEVELS, AND CALM THE BODY. 2012 5 2547 18 YOGA FOR BRONCHIAL ASTHMA: A CONTROLLED STUDY. FIFTY THREE PATIENTS WITH ASTHMA UNDERWENT TRAINING FOR TWO WEEKS IN AN INTEGRATED SET OF YOGA EXERCISES, INCLUDING BREATHING EXERCISES, SURYANAMASKAR, YOGASANA (PHYSICAL POSTURES), PRANAYAMA (BREATH SLOWING TECHNIQUES), DHYANA (MEDITATION), AND A DEVOTIONAL SESSION, AND WERE TOLD TO PRACTISE THESE EXERCISES FOR 65 MINUTES DAILY. THEY WERE THEN COMPARED WITH A CONTROL GROUP OF 53 PATIENTS WITH ASTHMA MATCHED FOR AGE, SEX, AND TYPE AND SEVERITY OF ASTHMA, WHO CONTINUED TO TAKE THEIR USUAL DRUGS. THERE WAS A SIGNIFICANTLY GREATER IMPROVEMENT IN THE GROUP WHO PRACTISED YOGA IN THE WEEKLY NUMBER OF ATTACKS OF ASTHMA, SCORES FOR DRUG TREATMENT, AND PEAK FLOW RATE. THIS STUDY SHOWS THE EFFICACY OF YOGA IN THE LONG TERM MANAGEMENT OF BRONCHIAL ASTHMA, BUT THE PHYSIOLOGICAL BASIS FOR THIS BENEFICIAL EFFECT NEEDS TO BE EXAMINED IN MORE DETAIL. 1985 6 1443 14 INCREASED MUSCLE ENZYME ACTIVITY AFTER YOGA BREATHING DURING AN EXACERBATION OF ASTHMA. THE CASE IS REPORTED OF A YOGA PRACTITIONER WHO, DURING AN EXACERBATION OF ASTHMA, DEVELOPED A SUBSTANTIAL INCREASE IN SERUM MUSCLE ENZYMES. THIS WAS RELATED TO HIS YOGA BREATHING EXERCISES, WHICH HE USED TO ENHANCE THE DELIVERY OF AEROSOLISED BRONCHODILATORS. AS HIS CONDITION IMPROVED AND THE USE OF THESE YOGA MANOEUVRES DIMINISHED, THE MUSCLE ENZYME LEVELS FELL TO NORMAL. 1988 7 1123 15 EFFICACY OF NATUROPATHY AND YOGA IN BRONCHIAL ASTHMA. THE AIM OF THE STUDY WAS TO TEST THE EFFICACY OF A ONE MONTH IN-PATIENT NATUROPATHY AND YOGA PROGRAMME FOR PATIENTS WITH ASTHMA. RETROSPECTIVE DATA OF 159 BRONCHIAL ASTHMA PATIENTS, UNDERGOING THE NATUROPATHY AND YOGA PROGRAMME, WAS ANALYZED FOR FORCED VITAL CAPACITY, FORCED EXPIRATORY VOLUME AT THE END OF 1 SECOND, MAXIMUM VOLUNTARY VENTILATION AND PEAK EXPIRATORY FLOW RATE ON ADMISSION, 11TH DAY, ON DISCHARGE AND ONCE IN THREE MONTHS FOR THREE YEARS. THE PAIRED SAMPLE T TEST RESULTS SHOWED SIGNIFICANT INCREASE IN THE FORCED VITAL CAPACITY AND FORCED EXPIRATORY VOLUME FROM THE DATE OF ADMISSION UP TO 6TH MONTH (P < 0.0035) POST BONFERRONI CORRECTION. MAXIMUM VOLUNTARY VENTILATION SIGNIFICANTLY INCREASED FROM ADMISSION TILL THE DATE OF DISCHARGE (P < 0.0035) AND PEAK EXPIRATORY FLOW RATE SIGNIFICANTLY INCREASED FROM ADMISSION TILL THE 36TH MONTH OF FOLLOW-UP (P < 0.0035), POST BONFERRONI CORRECTION. THIS VALIDATED THE BENEFICIAL EFFECT OF COMBINING NATUROPATHY AND YOGA FOR THE MANAGEMENT OF BRONCHIAL ASTHMA. 2014 8 2929 16 [YOGA TO IMPROVE ASTHMA CONTROL IN SEVERE ASTHMATICS TREATED WITH BIOLOGICS]. WE CONDUCTED A PROSPECTIVE OBSERVATIONAL STUDY TO EVALUATE THE EFFICACY OF YOGA IN POORLY CONTROLLED SEVERE ASTHMATIC PATIENTS TREATED WITH MAXIMAL INHALED THERAPY AND BIOLOGICS. THE OBJECTIVE OF YOGA WAS TO IMPROVE BREATHING CONSCIOUSNESS, EXERCISING CONTROLLED VENTILATION WITH AND WITHOUT RETENTION, ABDOMINAL BREATHING OBSERVATION, IMPROVEMENT OF INSPIRATORY AND EXPIRATORY MUSCLES, OPENING OF THE CHEST, DIAPHRAGM EXERCISES AND RELAXATION. WE MEASURED EXHALED NITRIC OXIDE, FORCED EXPIRATORY VOLUME IN ONE SECOND, FORCED VITAL CAPACITY, ASTHMA CONTROL AND QUALITY OF LIFE QUESTIONNAIRES, ANXIETY AND DEPRESSION QUESTIONNAIRES BEFORE AND AFTER THE TENTH YOGA COURSE (PERFORMED TWICE A WEEK). HALF OF THE PATIENTS WHO WERE INVITED TO PARTICIPATE TO THE STUDY DECLINED DUE TO ORGANIZATION PROBLEMS. TWO PATIENTS WERE EXCLUDED DUE TO BRONCHITIS AND ARTHRALGIA RESPECTIVELY. THE ANALYSIS OF THE DATA FROM 12 PARTICIPANTS REVEALED SIGNIFICANT IMPROVEMENT IN ASTHMA CONTROL AND ASTHMA QUALITY OF LIFE QUESTIONNAIRES AND A REDUCTION OF ANXIETY.THE REGULAR PRACTICE OF YOGA IN SEVERE ASTHMATICS INSUFFICIENTLY CONTROLLED DESPITE MAXIMAL INHALED TREATMENT AND BIOTHERAPY SEEMS TO BE AN INTERESTING COMPLEMENTARY OPTION TO IMPROVE ASTHMA CONTROL. OUR RESULTS MUST BE CONFIRMED IN LARGER RANDOMIZED CONTROLLED TRIALS. 2020 9 1508 16 IS MAN ABLE TO BREATHE ONCE A MINUTE FOR AN HOUR?: THE EFFECT OF YOGA RESPIRATION ON BLOOD GASES. THE VENTILATORY RESPONSE TO HYPERCAPNIA AND ARTERIAL BLOOD GASES DURING UJJAI RESPIRATION OF ONCE PER MINUTE FOR AN HOUR WERE DETERMINED IN A PROFESSIONAL HATHA YOGI. THE RESULTS SUGGEST THAT LOWER CHEMOSENSITIVITY TO HYPERCAPNIA IN YOGA PRACTITIONERS MAY BE DUE TO AN ADAPTATION TO LOW ARTERIAL PH AND HIGH PACO2 FOR LONG PERIODS. 2002 10 751 13 EFFECT OF SHORT TERM YOGA PRACTICE ON VENTILATORY FUNCTION TESTS. TWENTYFIVE NORMAL MALE VOLUNTEERS UNDERGOING A TEN WEEKS COURSE IN THE PRACTICE OF YOGA HAVE BEEN STUDIED BY SOME PARAMETERS OF VENTILATORY FUNCTIONS TESTS. THE OBSERVATIONS RECORDED AT THE END OF TEN WEEKS OF THE COURSE HAVE SHOWN IMPROVED VENTILATORY FUNCTIONS IN THE FORM OF LOWERED RESPIRATORY RATE, INCREASED FORCED VITAL CAPACITY, FEV1, MAXIMUM BREATHING CAPACITY AND BREATH HOLDING TIME, WHILE TIDAL VOLUME AND %FEV1, DID NOT REVEAL ANY SIGNIFICANT CHANGE. THUS, A COMBINED PRACTICE OF YOGA SEEMS TO BE BENEFICIAL ON RESPIRATORY EFFICIENCY. 1988 11 572 14 DEFINITION OF A YOGA BREATHING (PRANAYAMA) PROTOCOL THAT IMPROVES LUNG FUNCTION. THIS STUDY TESTS THE HYPOTHESIS THAT YOGA BREATHING (PRANAYAMA) IMPROVES LUNG FUNCTION IN HEALTHY VOLUNTEERS DURING A 6-WEEK PROTOCOL. A RANDOMIZED CONTROLLED PILOT STUDY DEMONSTRATED AN IMPROVEMENT IN PEAK EXPIRATORY FLOW RATE AND FORCED EXPIRATORY VOLUME. THE EASY-TO-LEARN APPROACH CAN BE TRANSLATED TO THE INPATIENT AND OUTPATIENT SETTINGS. 2019 12 214 16 A STUDY OF THE EFFECT OF YOGA TRAINING ON PULMONARY FUNCTIONS IN PATIENTS WITH BRONCHIAL ASTHMA. THE ROLE OF YOGA BREATHING EXERCISES, AS AN ADJUNCT TREATMENT FOR BRONCHIAL ASTHMA IS WELL RECOGNIZED. ONE HUNDRED TWENTY PATIENTS OF ASTHMA WERE RANDOMIZED INTO TWO GROUPS I.E GROUP A (YOGA TRAINING GROUP) AND GROUP B (CONTROL GROUP). EACH GROUP INCLUDED SIXTY PATIENTS. PULMONARY FUNCTION TESTS WERE PERFORMED ON ALL THE PATIENTS AT BASELINE, AFTER 4 WEEKS AND THEN AFTER 8 WEEKS. MAJORITY OF THE SUBJECTS IN THE TWO GROUPS HAD MILD DISEASE (34 PATIENTS IN GROUP A AND 32 IN GROUP B). GROUP A SUBJECTS SHOWED A STATISTICALLY SIGNIFICANT INCREASING TREND (P < 0.01) IN % PREDICTED PEAK EXPIRATORY FLOW RATE (PEFR), FORCED EXPIRATORY VOLUME IN THE FIRST SECOND (FEV1), FORCED VITAL CAPACITY (FVC), FORCED MID EXPIRATORY FLOW IN 0.25-0.75 SECONDS (FEF25-75) AND FEV1/FVC% RATIO AT 4 WEEKS AND 8 WEEKS AS COMPARED TO GROUP B. THUS, YOGA BREATHING EXERCISES USED ADJUNCTIVELY WITH STANDARD PHARMACOLOGICAL TREATMENT SIGNIFICANTLY IMPROVES PULMONARY FUNCTIONS IN PATIENTS WITH BRONCHIAL ASTHMA. 2009 13 887 13 EFFECT OF YOGA TYPE BREATHING ON HEART RATE AND CARDIAC AXIS OF NORMAL SUBJECTS. EFFECT OF INSPIRATORY AND EXPIRATORY PHASES OF NORMAL QUIET BREATHING, DEEP BREATHING AND SAVITRI PRANAYAM TYPE BREATHING ON HEART RATE AND MEAN VENTRICULAR QRS AXIS WAS INVESTIGATED IN YOUNG, HEALTHY UNTRAINED SUBJECTS. PRANAYAM TYPE BREATHING PRODUCED SIGNIFICANT CARDIOACCELERATION AND INCREASE IN QRS AXIS DURING THE INSPIRATORY PHASE AS COMPARED TO EUPNEA. ON THE OTHER HAND, EXPIRATORY EFFORT DURING PRANAYAM TYPE BREATHING DID NOT PRODUCE ANY SIGNIFICANT CHANGE IN HEART RATE OR QRS AXIS. THE CHANGES IN HEART RATE AND QRS AXIS DURING THE INSPIRATORY AND EXPIRATORY PHASES OF PRANAYAM TYPE BREATHING WERE SIMILAR TO THE CHANGES OBSERVED DURING THE CORRESPONDING PHASES OF DEEP BREATHING. 1986 14 438 20 CARDIOVASCULAR AND RESPIRATORY EFFECT OF YOGIC SLOW BREATHING IN THE YOGA BEGINNER: WHAT IS THE BEST APPROACH? SLOW BREATHING INCREASES CARDIAC-VAGAL BAROREFLEX SENSITIVITY (BRS), IMPROVES OXYGEN SATURATION, LOWERS BLOOD PRESSURE, AND REDUCES ANXIETY. WITHIN THE YOGA TRADITION SLOW BREATHING IS OFTEN PAIRED WITH A CONTRACTION OF THE GLOTTIS MUSCLES. THIS RESISTANCE BREATH "UJJAYI" IS PERFORMED AT VARIOUS RATES AND RATIOS OF INSPIRATION/EXPIRATION. TO TEST WHETHER UJJAYI HAD ADDITIONAL POSITIVE EFFECTS TO SLOW BREATHING, WE COMPARED BRS AND VENTILATORY CONTROL UNDER DIFFERENT BREATHING PATTERNS (EQUAL/UNEQUAL INSPIRATION/EXPIRATION AT 6 BREATH/MIN, WITH/WITHOUT UJJAYI), IN 17 YOGA-NAIVE YOUNG HEALTHY PARTICIPANTS. BRS INCREASED WITH SLOW BREATHING TECHNIQUES WITH OR WITHOUT EXPIRATORY UJJAYI (P < 0.05 OR HIGHER) EXCEPT WITH INSPIRATORY + EXPIRATORY UJJAYI. THE MAXIMAL INCREASE IN BRS AND DECREASE IN BLOOD PRESSURE WERE FOUND IN SLOW BREATHING WITH EQUAL INSPIRATION AND EXPIRATION. THIS CORRESPONDED WITH A SIGNIFICANT IMPROVEMENT IN OXYGEN SATURATION WITHOUT INCREASE IN HEART RATE AND VENTILATION. UJJAYI SHOWED SIMILAR INCREASE IN OXYGEN SATURATION BUT SLIGHTLY LESSER IMPROVEMENT IN BAROREFLEX SENSITIVITY WITH NO CHANGE IN BLOOD PRESSURE. THE SLOW BREATHING WITH EQUAL INSPIRATION AND EXPIRATION SEEMS THE BEST TECHNIQUE FOR IMPROVING BAROREFLEX SENSITIVITY IN YOGA-NAIVE SUBJECTS. THE EFFECTS OF UJJAYI SEEMS DEPENDENT ON INCREASED INTRATHORACIC PRESSURE THAT REQUIRES GREATER EFFORT THAN NORMAL SLOW BREATHING. 2013 15 1012 38 EFFECTS OF ONE MONTH OF COMMON YOGA PROTOCOL PRACTICE APPEAR TO BE MEDIATED BY THE ANGIOGENIC AND NEUROGENIC PATHWAY: A PILOT STUDY. OBJECTIVE: TO EXAMINE THE MOLECULAR EFFECTS OF MINDFUL ACTIVITIES SUCH AS YOGA AND MEDITATION DESIGN: THIS WAS AN OPEN LABEL SINGLE ARM EXPLORATORY YOGA INTERVENTION STUDY. STUDY PARTICIPANTS: 64 HEALTHY INDIVIDUALS WITHIN THE AGE OF 18-60 YEARS WERE RECRUITED FOR THIS ONE MONTH YOGA INTERVENTION STUDY. INTERVENTION: COMMON YOGA PROTOCOL (CYP) IS A STANDARDIZED YOGA PROTOCOL RELEASED BY MINISTRY OF AYUSH, INDIA FOR INTERNATIONAL YOGA DAY. IT INCLUDES ALL ASPECTS OF YOGA I.E. ASANAS, PRANAYAMA AND MEDITATION. IT IS DESIGNED FOR ADOPTION BY ALL AGE GROUPS FOR THE HEALTH OF COMMUNITY. OUTCOME MEASURES: THE PARTICIPANTS WERE ASSESSED FOR BIOCHEMICAL PARAMETERS INCLUDING FASTING SUGAR AND LIPID PROFILE. THE MOLECULAR MARKERS OF NEUROGENESIS (I.E. BRAIN DERIVED NEUROTROPIC FACTOR, BDNF) AND ANGIOGENESIS (I.E. VASCULAR ENDOTHELIAL GROWTH FACTOR, VEGF AND ANGIOGENIN) ALONG WITH AMYLOID BETA (MARKER RELATED TO NEURO-DEGENERATIVE DISEASES) WERE ASSESSED. ALL THE ASSESSMENTS WERE MADE AT BASELINE AND AFTER ONE MONTH OF THE INTERVENTION. RESULTS: AFTER ONE MONTH OF CYP PRACTICE HIGH DENSITY LIPOPROTEIN (HDL) LEVELS INCREASED SIGNIFICANTLY (P<0.001), ALTHOUGH OTHER BIOCHEMICAL PARAMETERS I.E. FASTING SUGAR AND OTHER LIPID ASSESSMENTS WERE FOUND TO BE UNALTERED. ANGIOGENESIS MARKER, ANGIOGENIN WAS INCREASED SIGNIFICANTLY (P<0.002), OTHER ANGIOGENESIS MARKER VEGF DID NOT SHOW ANY CHANGE ALONG WITH BDNF, MARKER OF NEUROGENESIS. AMYLOID BETA LEVELS WERE ALSO UNALTERED. EVEN THOUGH INDIVIDUAL LEVELS OF VEGF AND AMYLOID BETA DID NOT SHOW ANY CHANGE, PROPORTION OF VEGF TO AMYLOID BETA SHOWED A SIGNIFICANT INCREASE (P<0.001) AFTER ONE MONTH OF CYP INTERVENTION INDICATING THAT THE CHANGE IN VEGF LEVELS WAS SIGNIFICANTLY HIGHER THAN THE CHANGE IN AMYLOID BETA LEVELS. CONCLUSION: CYP PRACTICE MAY INFLUENCE CELL SURVIVAL PATHWAYS MEDIATED BY ANGIOGENIC AND NEUROGENIC CROSS TALK. HENCE, CYP CAN BE CONSIDERED AS A PREVENTIVE MEASURE FOR DISEASES ASSOCIATED WITH IMPAIRED ANGIOGENIC AND NEUROGENIC MECHANISM. THIS IS THE FIRST STUDY TO EXAMINE THE EFFECTS OF CYP AT THE MOLECULAR LEVEL. 2021 16 436 22 CARDIORESPIRATORY AND METABOLIC CHANGES DURING YOGA SESSIONS: THE EFFECTS OF RESPIRATORY EXERCISES AND MEDITATION PRACTICES. THE NOVELTY OF THIS STUDY WAS TO INVESTIGATE THE CHANGES IN CARDIORESPIRATORY AND METABOLIC INTENSITY BROUGHT ABOUT BY THE PRACTICE OF PRANAYAMAS (BREATHING EXERCISES OF YOGA) AND MEDITATION DURING THE SAME HATHA-YOGA SESSION. THE TECHNIQUE APPLIED WAS THE ONE ADVOCATED BY THE HATHA-YOGA SYSTEM. NINE YOGA INSTRUCTORS-FIVE FEMALES AND FOUR MALES, MEAN AGE OF 44+/-11, 6, WERE SUBJECTED TO ANALYSIS OF THE GASES EXPIRED DURING THREE DISTINCT PERIODS OF 30 MIN: REST, RESPIRATORY EXERCISES AND MEDITATIVE PRACTICE. A METABOLIC OPEN CIRCUIT COMPUTERIZED SYSTEM WAS APPLIED (VO2000, MEDGRAPHICS-USA). THE OXYGEN UPTAKE (VO(2)) AND THE CARBON DIOXIDE OUTPUT (VCO(2)) WERE STATISTICALLY DIFFERENT (P