1 1667 156 NEUROCHEMICAL AND NEUROANATOMICAL PLASTICITY FOLLOWING MEMORY TRAINING AND YOGA INTERVENTIONS IN OLDER ADULTS WITH MILD COGNITIVE IMPAIRMENT. BEHAVIORAL INTERVENTIONS ARE BECOMING INCREASINGLY POPULAR APPROACHES TO AMELIORATE AGE-RELATED COGNITIVE DECLINE, BUT THEIR UNDERLYING NEUROBIOLOGICAL MECHANISMS AND CLINICAL EFFICIENCY HAVE NOT BEEN FULLY ELUCIDATED. THE PRESENT STUDY EXPLORED BRAIN PLASTICITY ASSOCIATED WITH TWO BEHAVIORAL INTERVENTIONS, MEMORY ENHANCEMENT TRAINING (MET) AND A MIND-BODY PRACTICE (YOGIC MEDITATION), IN HEALTHY SENIORS WITH MILD COGNITIVE IMPAIRMENT (MCI) USING STRUCTURAL MAGNETIC RESONANCE IMAGING (S-MRI) AND PROTON MAGNETIC RESONANCE SPECTROSCOPY ((1)H-MRS). SENIOR PARTICIPANTS (AGE >/=55 YEARS) WITH MCI WERE RANDOMIZED TO THE MET OR YOGIC MEDITATION INTERVENTIONS. FOR BOTH INTERVENTIONS, PARTICIPANTS COMPLETED EITHER MET TRAINING OR KUNDALINI YOGA (KY) FOR 60-MIN SESSIONS OVER 12 WEEKS, WITH 12-MIN DAILY HOMEWORK ASSIGNMENTS. GRAY MATTER VOLUME AND METABOLITE CONCENTRATIONS IN THE DORSAL ANTERIOR CINGULATE CORTEX (DACC) AND BILATERAL HIPPOCAMPUS WERE MEASURED BY STRUCTURAL MRI AND (1)H-MRS AT BASELINE AND AFTER 12 WEEKS OF TRAINING. METABOLITES MEASURED INCLUDED GLUTAMATE-GLUTAMINE (GLX), CHOLINE-CONTAINING COMPOUNDS (CHO, INCLUDING GLYCEROPHOSPHOCHOLINE AND PHOSPHOCHOLINE), GAMMA-AMINOBUTYRIC ACID (GABA), AND N-ACETYL ASPARTATE AND N-ACETYLASPARTYL-GLUTAMATE (NAA-NAAG). IN TOTAL, 11 PARTICIPANTS COMPLETED MET AND 14 COMPLETED YOGIC MEDITATION FOR THIS STUDY. STRUCTURAL MRI ANALYSIS SHOWED AN INTERACTION BETWEEN TIME AND GROUP IN DACC, INDICATING A TREND TOWARDS INCREASED GRAY MATTER VOLUME AFTER THE MET INTERVENTION. (1)H-MRS ANALYSIS SHOWED AN INTERACTION BETWEEN TIME AND GROUP IN CHOLINE-CONTAINING COMPOUNDS IN BILATERAL HIPPOCAMPUS, INDUCED BY SIGNIFICANT DECREASES AFTER THE MET INTERVENTION. THOUGH PRELIMINARY, OUR RESULTS SUGGEST THAT MEMORY TRAINING INDUCES STRUCTURAL AND NEUROCHEMICAL PLASTICITY IN SENIORS WITH MCI. FURTHER RESEARCH IS NEEDED TO DETERMINE WHETHER MIND-BODY INTERVENTIONS LIKE YOGA YIELD SIMILAR NEUROPLASTIC CHANGES. 2016 2 2886 31 YOGA: BALANCING THE EXCITATION-INHIBITION EQUILIBRIUM IN PSYCHIATRIC DISORDERS. SOCIAL BEHAVIORAL DISTURBANCES ARE CENTRAL TO MOST PSYCHIATRIC DISORDERS. A DISEQUILIBRIUM WITHIN THE CORTICAL EXCITATORY AND INHIBITORY NEUROTRANSMITTER SYSTEMS UNDERLIES THESE DEFICITS. GAMMA-AMINOBUTYRIC ACID (GABA) AND GLUTAMATE ARE THE MOST ABUNDANT EXCITATORY AND INHIBITORY NEUROTRANSMITTERS IN THE BRAIN THAT CONTRIBUTE TO THIS EQUILIBRIUM. SEVERAL CONTEMPORARY THERAPIES USED IN TREATING PSYCHIATRIC DISORDERS, REGULATE THIS GABA-GLUTAMATE BALANCE. YOGA HAS BEEN STUDIED AS AN ADJUVANT TREATMENT ACROSS A BROAD RANGE OF PSYCHIATRIC DISORDERS AND IS SHOWN TO HAVE SHORT-TERM THERAPEUTIC GAINS. EMERGING EVIDENCE FROM RECENT CLINICAL IN VIVO EXPERIMENTS SUGGESTS THAT YOGA IMPROVES GABA-MEDIATED CORTICAL-INHIBITORY TONE AND ENHANCES PERIPHERAL OXYTOCIN LEVELS. THIS IS LIKELY TO HAVE A MORE CONTROLLED DOWNSTREAM RESPONSE OF THE HYPOTHALAMO-PITUITARY-ADRENAL SYSTEM BY MEANS OF REDUCED CORTISOL RELEASE AND HENCE A BLUNTED SYMPATHETIC RESPONSE TO STRESS. ANIMAL AND EARLY FETAL DEVELOPMENTAL STUDIES SUGGEST AN INTER-DEPENDENT ROLE OF OXYTOCIN AND GABA IN REGULATING SOCIAL BEHAVIORS. IN KEEPING WITH THESE OBSERVATIONS, WE PROPOSE AN INTEGRATED NEUROBIOLOGICAL MODEL TO STUDY THE MECHANISMS OF THERAPEUTIC BENEFITS WITH YOGA. APART FROM PROVIDING A NEUROSCIENTIFIC BASIS FOR APPLYING A TRADITIONAL SYSTEM OF PRACTICE IN THE CLINICAL SETTING, THIS MODEL CAN BE USED AS A FRAMEWORK FOR STUDYING YOGA MECHANISMS IN FUTURE CLINICAL TRIALS. 2019 3 1603 19 MENTAL DEPRESSION AND KUNDALINI YOGA. IN CASES OF MENTAL DEPRESSION, THE PLASMA SEROTONIN, MELATONIN AND GLUTAMATE LEVELS ARE INCREASED ALONG WITH THE LOWERING OF URINARY - 5 - HYDROXYINDOLE ACETIC ACID, PLASMA MONOAMINE OXIDASE AND CORTISOL LEVELS FOLLOWING THREE AND SIX MONTHS PRACTICE OF KUNDALINI YOGA. THE PULSE RATE AND BLOOD PRESSURE IN THESE PATIENTS ARE ALSO LOWERED AFTER KUNDALINI YOGA PRACTICE. THUS, THE PRACTICE OF KUNDALINI YOGA HELPS TO MAINTAIN A PERFECT HOMEOSTASIS BY BRINGING AN EQUILIBRIUM BETWEEN THE SYMPATHETIC AND PARASYMPATHETIC ACTIVITIES AND IT CAN BE USED AS A NON - MEDICAL MEASURE IN TREATING PATIENTS WITH MENTAL DEPRESSION. 1986 4 1634 29 MODELING THE EFFECTS OF YOGA ON THE PROGRESSION OF ALZHEIMER'S DISEASE IN A DISH. ALZHEIMER'S DISEASE (AD) ACCOUNTS FOR 80% OF ALL DEMENTIA CASES, MAKING IT THE MOST COMMON FORM OF DEMENTIA. AGING SERVES AS THE MAIN RISK FACTOR FOR AD, BUT EARLY ONSET AD CAN ALSO OCCUR IN INDIVIDUALS YOUNGER THAN 65 YEARS. AD RESULTS FROM PROGRESSIVE NEURODEGENERATION LEADING TO DYSFUNCTIONAL SYNAPTIC TRANSMISSION IN THE BRAIN. THE CASCADE HYPOTHESIS OF AD STATES THAT AMYLOID PRECURSOR PROTEIN (APP) METABOLISM BECOMES IMPAIRED EITHER BY MUTATION OR AN INTERLEUKIN-MEDIATED STRESS RESPONSE TO INJURY, RESULTING IN THE SPLICING OF HARMFUL OLIGOMERIC FORMS OF AMYLOID BETA (ABETA). THESE OLIGOMERS DISRUPT EXTRACELLULAR RECEPTOR BINDING, INTRACELLULAR FUNCTION, AND CELLULAR MEMBRANE INTEGRITY. YOGA AND MEDITATIVE PRACTICES SLOW THE PROGRESSION OF THE COGNITIVE DECLINE ASSOCIATED WITH AD. HOWEVER, THE BIOLOGICAL MECHANISMS UNDERLYING THIS THERAPEUTIC EFFECT REMAIN ELUSIVE. HERE, WE INVESTIGATED THE ABILITY OF NEUROTRANSMITTERS RELEASED DURING YOGA AND MEDITATIVE PRACTICES TO RESCUE NEURONS FROM SYNAPTIC DYSFUNCTION IN AN IN VITRO ALZHEIMER'S MODEL CREATED BY CULTURING BASAL FOREBRAIN CHOLINERGIC NEURONS WITH PHYSIOLOGICALLY RELEVANT LEVELS OF THE I-42 ISOFORM OF OLIGOMERIC ABETA (OALPHABETAI-42). WE FOUND THAT THE NEUROTRANSMITTERS DOPAMINE AND HISTAMINE PRODUCE A COOPERATIVE ACTION WITH SEROTONIN TO REVERSE THE LOSS OF CHOLINE ACETYLTRANSFERASE (CHAT) BY OALPHABETAI-42. THE LOSS OF CHAT, THE ENZYME RESPONSIBLE FOR PROCESSING THE CHOLINERGIC NEUROTRANSMITTER ACETYLCHOLINE, CONTRIBUTES TO THE SYNAPTIC DYSFUNCTION EXPERIENCED DURING AD. THESE NEUROTRANSMITTERS INHIBIT NITRIC OXIDE SYNTHESIS CAUSED BY OALPHABETAI-42, PREVENTING OXIDATIVE AND NITROSATIVE STRESS. SEROTONIN ACTIVATES AN ALTERNATE CLEAVAGE OF APP TO PRODUCE A FRAGMENT WITH KNOWN NEUROTROPHIC EFFECTS, GIVING IT THE UNIQUE ABILITY TO INHIBIT THE OALPHABETAI-42 PRODUCTION CYCLE. WE HYPOTHESIZE HERE THAT THESE CONCERTED ACTIONS LEAD TO THE PROTECTION OF CHOLINERGIC SYNAPTIC TRANSMISSION IN AD. 2018 5 1775 16 PRACTICE OF YOGA MAY CAUSE DAMAGE OF BOTH SCIATIC NERVES: A CASE REPORT. SCIATIC NERVE TRAUMATIC DAMAGE VERY RARELY OCCURS BILATERALLY. WE DESCRIBE THE CASE OF A 67-YEAR-OLD WOMAN WHO REPORTED A BILATERAL TRAUMATIC LESION OF THE SCIATIC NERVE DURING PRACTICE OF YOGA. NERVE CONDUCTION STUDIES SHOWED A BILATERAL SCIATIC NERVE NEUROPATHY, MOSTLY AFFECTING THE PERONEAL COMPONENT. LUMBAR PLEXUS MRI DOCUMENTED REGULAR ANATOMICAL FEATURES OF THE MAIN PRINCIPAL NERVE ROOTS WITH BILATERAL T2 SIGNAL ALTERATION OF ROOTS L4, L5 AND S1 THAT EXTENDED INTO THE SCIATIC NERVES SHOWING BOTH INCREASE IN SIZE, PROBABLY RELATED TO CHRONIC INJURY OF NERVES, AND AN ALTERATION IN DIFFUSION SIGNAL THAT SUGGESTED A RECENT ACUTE OVERLAPPED PROCESS. 2013 6 1952 14 SEASONAL AFFECTIVE DISORDER AND THE YOGA PARADIGM: A RECONSIDERATION OF THE ROLE OF THE PINEAL GLAND. SEASONAL AFFECTIVE DISORDER IS A PSYCHIATRIC DISORDER WHOSE PATHOPHYSIOLOGY AND CLINICAL PRESENTATION ARE POORLY UNDERSTOOD. BY APPLYING THE ANCIENT PARADIGM OF YOGA PSYCHOLOGY TO THIS SUBJECT, NEW UNDERSTANDINGS OF THE SYNDROME EMERGE REGARDING THE POSSIBLE ROLE OF THE PINEAL GLAND, THE CLINICAL PRESENTATION OF THE SYNDROME, AND THE POSSIBLE MECHANISM OF ACTION OF PHOTOTHERAPY. THE ENERGY DEPLETION MODEL PRESENTED HERE TIES TOGETHER SUCH DIVERSE ELEMENTS AS: DOSE-RESPONSE ASPECTS OF PHOTOTHERAPY, ANERGIA AS A PRIMARY SYMPTOM OF SAD, 'SPRING FEVER', MYOFASCIAL PAIN DISORDER, THE ANTI-GONADOTROPHIC EFFECT OF MELATONIN, AND PINEAL SUPERSENSITIVITY IN BIPOLAR PATIENTS. CLINICAL PREDICTIONS ARE MADE, AND SIMPLE RESEARCH PROTOCOLS ARE SUGGESTED WHICH CAN DIRECTLY TEST THE HYPOTHESES GENERATED BY THIS PARADIGM. 1990 7 1472 29 INSULAR CORTEX MEDIATES INCREASED PAIN TOLERANCE IN YOGA PRACTITIONERS. YOGA, AN INCREASINGLY POPULAR DISCIPLINE AMONG WESTERNERS, IS FREQUENTLY USED TO IMPROVE PAINFUL CONDITIONS. WE INVESTIGATED POSSIBLE NEUROANATOMICAL UNDERPINNINGS OF THE BENEFICIAL EFFECTS OF YOGA USING SENSORY TESTING AND MAGNETIC RESONANCE IMAGING TECHNIQUES. NORTH AMERICAN YOGIS TOLERATED PAIN MORE THAN TWICE AS LONG AS INDIVIDUALLY MATCHED CONTROLS AND HAD MORE GRAY MATTER (GM) IN MULTIPLE BRAIN REGIONS. ACROSS SUBJECTS, INSULAR GM UNIQUELY CORRELATED WITH PAIN TOLERANCE. INSULAR GM VOLUME IN YOGIS POSITIVELY CORRELATED WITH YOGA EXPERIENCE, SUGGESTING A CAUSAL RELATIONSHIP BETWEEN YOGA AND INSULAR SIZE. YOGIS ALSO HAD INCREASED LEFT INTRAINSULAR WHITE MATTER INTEGRITY, CONSISTENT WITH A STRENGTHENED INSULAR INTEGRATION OF NOCICEPTIVE INPUT AND PARASYMPATHETIC AUTONOMIC REGULATION. YOGIS, AS OPPOSED TO CONTROLS, USED COGNITIVE STRATEGIES INVOLVING PARASYMPATHETIC ACTIVATION AND INTEROCEPTIVE AWARENESS TO TOLERATE PAIN, WHICH COULD HAVE LED TO USE-DEPENDENT HYPERTROPHY OF INSULAR CORTEX. TOGETHER, THESE FINDINGS SUGGEST THAT REGULAR AND LONG-TERM YOGA PRACTICE IMPROVES PAIN TOLERANCE IN TYPICAL NORTH AMERICANS BY TEACHING DIFFERENT WAYS TO DEAL WITH SENSORY INPUTS AND THE POTENTIAL EMOTIONAL REACTIONS ATTACHED TO THOSE INPUTS LEADING TO A CHANGE IN INSULAR BRAIN ANATOMY AND CONNECTIVITY. 2014 8 1670 32 NEUROPROTECTIVE EFFECTS OF YOGA PRACTICE: AGE-, EXPERIENCE-, AND FREQUENCY-DEPENDENT PLASTICITY. YOGA COMBINES POSTURES, BREATHING, AND MEDITATION. DESPITE REPORTED HEALTH BENEFITS, YOGA'S EFFECTS ON THE BRAIN HAVE RECEIVED LITTLE STUDY. WE USED MAGNETIC RESONANCE IMAGING TO COMPARE AGE-RELATED GRAY MATTER (GM) DECLINE IN YOGIS AND CONTROLS. WE ALSO EXAMINED THE EFFECT OF INCREASING YOGA EXPERIENCE AND WEEKLY PRACTICE ON GM VOLUME AND ASSESSED WHICH ASPECTS OF WEEKLY PRACTICE CONTRIBUTED MOST TO BRAIN SIZE. CONTROLS DISPLAYED THE WELL DOCUMENTED AGE-RELATED GLOBAL BRAIN GM DECLINE WHILE YOGIS DID NOT, SUGGESTING THAT YOGA CONTRIBUTES TO PROTECT THE BRAIN AGAINST AGE-RELATED DECLINE. YEARS OF YOGA EXPERIENCE CORRELATED MOSTLY WITH GM VOLUME DIFFERENCES IN THE LEFT HEMISPHERE (INSULA, FRONTAL OPERCULUM, AND ORBITOFRONTAL CORTEX) SUGGESTING THAT YOGA TUNES THE BRAIN TOWARD A PARASYMPATICALLY DRIVEN MODE AND POSITIVE STATES. THE NUMBER OF HOURS OF WEEKLY PRACTICE CORRELATED WITH GM VOLUME IN THE PRIMARY SOMATOSENSORY CORTEX/SUPERIOR PARIETAL LOBULE (S1/SPL), PRECUNEUS/POSTERIOR CINGULATE CORTEX (PCC), HIPPOCAMPUS, AND PRIMARY VISUAL CORTEX (V1). COMMONALITY ANALYSES INDICATED THAT THE COMBINATION OF POSTURES AND MEDITATION CONTRIBUTED THE MOST TO THE SIZE OF THE HIPPOCAMPUS, PRECUNEUS/PCC, AND S1/SPL WHILE THE COMBINATION OF MEDITATION AND BREATHING EXERCISES CONTRIBUTED THE MOST TO V1 VOLUME. YOGA'S POTENTIAL NEUROPROTECTIVE EFFECTS MAY PROVIDE A NEURAL BASIS FOR SOME OF ITS BENEFICIAL EFFECTS. 2015 9 2714 27 YOGA LESSONS FOR CONSCIOUSNESS RESEARCH: A PARALIMBIC NETWORK BALANCING BRAIN RESOURCE ALLOCATION. CONSCIOUSNESS HAS BEEN PROPOSED TO PLAY A KEY ROLE IN SHAPING FLEXIBLE LEARNING AND AS SUCH IS THOUGHT TO CONFER AN EVOLUTIONARY ADVANTAGE. ATTENTION AND AWARENESS ARE THE PERHAPS MOST IMPORTANT UNDERLYING PROCESSES, YET THEIR PRECISE RELATIONSHIP IS PRESENTLY UNCLEAR. BOTH OF THESE PROCESSES MUST, HOWEVER, SERVE THE EVOLUTIONARY IMPERATIVES OF SURVIVAL AND PROCREATION. THEY ARE THUS INTIMATELY BOUND BY REWARD AND EMOTION TO HELP TO PRIORITIZE EFFICIENT BRAIN RESOURCE ALLOCATION IN ORDER TO PREDICT AND OPTIMIZE BEHAVIOR. HERE WE SHOW HOW THIS PROCESS IS SERVED BY A PARALIMBIC NETWORK CONSISTING PRIMARILY OF REGIONS LOCATED ON THE MIDLINE OF THE HUMAN BRAIN. USING MANY DIFFERENT TECHNIQUES, EXPERIMENTS HAVE DEMONSTRATED THAT THIS NETWORK IS EFFECTIVE AND SPECIFIC FOR SELF-AWARENESS AND CONTRIBUTES TO THE SENSE OF UNITY OF CONSCIOUSNESS BY ACTING AS A COMMON NEURAL PATH FOR A WIDE VARIETY OF CONSCIOUS EXPERIENCES. INTERESTINGLY, HEMODYNAMIC ACTIVITY IN THE NETWORK DECREASES WITH FOCUSING ON EXTERNAL STIMULI, WHICH HAS LED TO THE IDEA OF A DEFAULT MODE NETWORK. THIS NETWORK IS ONE OF MANY NETWORKS THAT WAX AND VANE AS RESOURCES ARE ALLOCATED TO ACCOMMODATE THE DIFFERENT CYCLICAL NEEDS OF THE ORGANISM PRIMARILY RELATED TO THE FUNDAMENTAL PLEASURES AFFORDED BY EVOLUTION: FOOD, SEX, AND CONSPECIFICS. HERE WE HYPOTHESIZE, HOWEVER, THAT THE PARALIMBIC NETWORK SERVES A CRUCIAL ROLE IN BALANCING AND REGULATING BRAIN RESOURCE ALLOCATION, AND DISCUSS HOW IT CAN BE THOUGHT OF AS A LINK BETWEEN CURRENT THEORIES OF SO-CALLED "DEFAULT MODE," "RESTING STATE NETWORKS," AND "GLOBAL WORKSPACE." WE SHOW HOW MAJOR DEVELOPMENTAL DISORDERS OF SELF-AWARENESS AND SELF-CONTROL CAN ARISE FROM PROBLEMS IN THE PARALIMBIC NETWORK AS DEMONSTRATED HERE BY THE EXAMPLE OF ASPERGER SYNDROME. WE CONCLUDE THAT ATTENTION, AWARENESS, AND EMOTION ARE INTEGRATED BY A PARALIMBIC NETWORK THAT HELPS TO EFFICIENTLY ALLOCATE BRAIN RESOURCES TO OPTIMIZE BEHAVIOR AND HELP SURVIVAL. 2011 10 407 20 BIOLOGICAL SIGNIFICANCE OF PIEZOELECTRICITY IN RELATION TO ACUPUNCTURE, HATHA YOGA, OSTEOPATHIC MEDICINE AND ACTION OF AIR IONS. PIEZOELECTRIC PROPERTIES OF BIOLOGICAL MACROMOLECULES SUCH AS PROTEINS, NUCLEIC ACIDS AND MUCOPOLYSACCHARIDES ARE REVIEWED IN THIS PAPER. IT IS INDICATED THAT THE STRUCTURAL ELEMENTS OF THE HUMAN BODY COMPOSED OF THESE PIEZOELECTRIC SUBSTANCES ARE CAPABLE OF TRANSDUCING A MECHANICAL ENERGY INTO AN ELECTRIC CURRENT. SUCH A TRANSDUCTION MAY BE BROUGHT ABOUT BY MOVEMENTS OF AN ACUPUNCTURE NEEDLE, OSTEOPATHIC MANIPULATIONS; HATHA YOGA POSTURES OR ACTION OF NEGATIVELY CHARGED AIR IRONS. IT IS POSTULATED THAT ELECTRIC CURRENT INDUCED BY STIMULATION OF THE SPECIFIC SITES ON THE SURFACE OF HUMAN BODY FLOWS TOWARDS THE INTERNAL ORGANS ALONG THE SEMICONDUCTIVE CHANNELS OF BIOLOGIC MACROMOLECULES. ELECTRIC CURRENT INDUCED EITHER BY THE PIEZOELECTRIC TRANSDUCTION OR DIRECTLY APPLIED FROM AN EXTERNAL SOURCE MAY IN TURN STIMULATE INDIVIDUAL CELLS IN THE TARGET ORGAN. INVOLVEMENT OF ELECTRICAL PHENOMENA IN REGULATORY MECHANISMS ON CELLULAR AND MOLECULAR LEVELS IS DISCUSSED. 1977 11 2907 24 [ON THE METHODOLOGICAL APPROACH TO THE ELUCIDATION OF MECHANISMS UNDERLYING THERAPEUTIC EFFECTIVENESS OF CIGUN, INDIAN AND TIBETAN YOGA THERAPY]. THE METHODOLOGICAL APPROACH IS PROPOSED ALLOWING TO OBJECTIVELY CHARACTERIZE NEUROPHYSIOLOGICAL MECHANISMS UNDERLYING THERAPEUTIC EFFECTIVENESS OF CIGUN, INDIAN AND TIBETAN YOGA THERAPY. EXECUTION OF EXERCISES STIPULATED IN THESE PROGRAMS IS INTERPRETED AS A CONSCIOUSNESS-INSPIRED SPECIFIC FORM OF HUMAN BEHAVIOUR (ACTIVITY). STEP-BY-STEP ANALYSIS OF MENTALLY-ORGANIZED BODY'S FUNCTIONAL SYSTEMS AS A NEUROPHYSIOLOGICAL BASIS OF REALIZABLE BEHAVIOUR IS PRESENTED. OPERATIONAL INTERPRETATION OF INTERNAL MECHANISMS UNDERLYING THE SYSTEM'S FUNCTIONING PERMITS TO EVALUATE THE STEREOTYPE BRAIN CONDITION ACTUALIZED BY SPECIFIC REQUIREMENTS AND MOTIVATIONS THAT INITIATES SENSORY DEPRIVATION TO ENSURE PRIORITY REALIZATION OF INTERNAL GENETICALLY DETERMINED ACTIVITY OF THE HUMAN BODY. MOBILIZATION OF THIS INTERNAL ACTIVITY IS DESCRIBED AS A PROCESS OF SELECTIVE FORMATION OF MANY COMPLICATED INTERACTIONS BETWEEN VARIOUS STRUCTURES OF THE RETICULAR FORMATION, LIMBIC SYSTEM, SUBCORTICAL CENTRES, AND NEOCORTEX MAINTAINING PRIORITY FUNCTIONING OF HOMEOSTATIC MECHANISMS OF SELF-REGULATION AND INBORN HUMAN BEHAVIOUR. THESE MECHANISMS ARE BELIEVED TO UNDERLIE THE AUTORECONSTRUCTIVE POTENTIAL OF HUMAN ORGANISM BY ENSURING SYSTEMIC CORRECTION AND RESTORATION OF ITS FUNCTIONAL RESOURCES. 2010 12 2912 28 [RECENT MEDICAL RESEARCH ON YOGA AND STATES OF CONCENTRATION]. TRADITIONAL ORIENTAL THINKING ATTRACTS THE GROWING SCIENTIFIC INTEREST OF OCCIDENTAL PRACTITIONERS. DR. PIERRE ETEVENON, HEAD OF THE DEPARTMENT OF NEURO-PSYCHO-PHARMACOLOGY AT THE FRENCH INSTITUTE FOR HEALTH AND MEDICAL RESEARCH (INSERM), HELD SEVERAL CONVERSATIONS AND SCIENTIFIC EXCHANGES WITH THE AUTHOR, AND KINDLY PROVIDED COPIES OF SOME OF HIS WORKS. THEY ARE AT THE BASIS OF THE PRESENT PAPER. M. A. DESCAMPS (PARIS) FOUND THAT ASANAS--YOGA POSTURES-- ARE GENERATORS OF DYNAMIC ACTION WHEN THERE IS AN EXTENSION OF THE SPINAL COLUMN, WHILST THEY LEAD TO QUIET STATES WHEN THERE IS A FLEXION OF IT. CLAEYS AND GONES (BELGIUM) PROVED THAT OVERALL GLOBAL RELAXATION, AS WELL AS DIFFERENTIAL RELAXATION WERE FAR MORE EFFECTIVE AND DEEP WHEN OBTAINED BY YOGIS THAN THOSE ATTEMPTED BY UNIVERSITY STUDENTS MAJORING IN PHYSICAL EDUCATION. LONSDORFER AND NUSSBAUM (FRANCE) STUDIED SEVERAL PARAMETERS CONCERNING HATHA-YOGA AND CONCLUDED THAT IT PROVIDES A REGULAR FUNCTIONING OF THE MAIN BODILY FUNCTIONS FOSTERING THUS A PSYCHO-PHYSICAL BALANCE. WALLACE AND BENSON (U.S.A.) PROVED THAT TRANSCENDENTAL MEDITATION INCREASES AEROBIC METABOLISM, COUNTERACTING ANAEROBIC METABOLISM WHICH IS RELATED TO MENTAL DISTRESS. ETEVENON (PARIS) INVESTIGATED NEUROPHYSIOLOGICAL EFFECTS OF YOGA IN CONNECTION TO ANCIENT INDIAN CONCEPTS (UPANISHADS) ON SLEEPING, MEDITATION AND DEGREE OF CONSCIOUSNESS. DR. ETEVENON HAS STUDIED THE PHYLOGENETIC EVOLUTION OF WAKING-SLEEPING CYCLES, FOCUSING ON PHYLOGENETIC AND ONTONGENETIC APPEARANCES OF REM CYCLES (ACTIVATED SLEEP). A CORRELATION HAS BEEN MADE WITH EEG STUDIES DURING STATES OF CONCENTRATION (YOGA, TRANSCENDENTAL MEDITATION, ZEN). THESE STATES HAVE BEEN FOUND TO BE SPECIFIC BRAIN ACTIVITIES, AND DIFFERENT FROM DEEP SLEEP, IN SPITE OF CERTAIN SIMILARITIES IN THE EEG. SEVERAL HYPOTHESIS ARE SET FORTH TO EXPLAIN BRAIN ACTIVITIES UNDERLYING SITES OF CONCENTRATION. THE POSSIBILITIES OF DEVELOPING A CONSCIOUS MASTERING OF DREAMS ARE ALSO UNDER RESEARCH, AND SPECIAL ATTENTION IS PAID TO THE WORKS OF SAINT DENYS (1867), AND HINDU TRADITION. THIS PAPER DISCUSSES ALSO THE PSYCHOLOGICAL, THERAPEUTIC AND ANTHROPOLOGICAL IMPLICATIONS OF RECENT DISCOVERIES IN THE FIELD. 1975 13 2608 18 YOGA FOR PSYCHIATRIC DISORDERS: FROM FAD TO EVIDENCE-BASED INTERVENTION? THERE IS GROWING EVIDENCE FOR YOGA'S NEUROBIOLOGICAL EFFECTS IN PEOPLE WITH PSYCHIATRIC DISORDERS. POSTULATED MECHANISMS OF ACTION INCLUDE: (A) MODULATION OF THE HYPOTHALAMIC-PITUITARY-ADRENAL (HPA) AXIS; (B) ENHANCEMENT OF GABAERGIC NEUROTRANSMISSION; (C) AUTONOMIC MODULATION; AND (D) NEUROENDOCRINOLOGICAL EFFECTS. YOGA AS A THERAPEUTIC INTERVENTION IN PSYCHIATRIC DISORDERS APPEARS PROMISING AND MERITS FURTHER ATTENTION IN CLINICAL PRACTICE AND RESEARCH. 2020 14 2724 14 YOGA NEUROPATHY. A SNOOZER. SCIATIC NERVE COMPRESSION VERY RARELY OCCURS BILATERALLY. THE AUTHORS PRESENT A WOMAN WITH PROFOUND LOWER EXTREMITY WEAKNESS AND SENSORY ABNORMALITY AFTER FALLING ASLEEP IN THE HEAD-TO-KNEES YOGA POSITION (ALSO CALLED "PASCHIMOTTANASANA"). CLINICAL AND ELECTRODIAGNOSTIC FINDINGS ARE DISCUSSED IN DETAIL AND A BRIEF REVIEW OF THE LITERATURE IS PRESENTED. 2005 15 1439 30 INCREASED GREY MATTER ASSOCIATED WITH LONG-TERM SAHAJA YOGA MEDITATION: A VOXEL-BASED MORPHOMETRY STUDY. OBJECTIVES: TO INVESTIGATE REGIONAL DIFFERENCES IN GREY MATTER VOLUME ASSOCIATED WITH THE PRACTICE OF SAHAJA YOGA MEDITATION. DESIGN: TWENTY THREE EXPERIENCED PRACTITIONERS OF SAHAJA YOGA MEDITATION AND TWENTY THREE NON-MEDITATORS MATCHED ON AGE, GENDER AND EDUCATION LEVEL, WERE SCANNED USING STRUCTURAL MAGNETIC RESONANCE IMAGING AND THEIR GREY MATTER VOLUME WERE COMPARED USING VOXEL-BASED MORPHOMETRY. RESULTS: GREY MATTER VOLUME WAS LARGER IN MEDITATORS RELATIVE TO NON-MEDITATORS ACROSS THE WHOLE BRAIN. IN ADDITION, GREY MATTER VOLUME WAS LARGER IN SEVERAL PREDOMINANTLY RIGHT HEMISPHERIC REGIONS: IN INSULA, VENTROMEDIAL ORBITOFRONTAL CORTEX, INFERIOR TEMPORAL AND PARIETAL CORTICES AS WELL AS IN LEFT VENTROLATERAL PREFRONTAL CORTEX AND LEFT INSULA. NO AREAS WITH LARGER GREY MATTER VOLUME WERE FOUND IN NON-MEDITATORS RELATIVE TO MEDITATORS. CONCLUSIONS: THE STUDY SHOWS THAT LONG-TERM PRACTICE OF SAHAJA YOGA MEDITATION IS ASSOCIATED WITH LARGER GREY MATTER VOLUME OVERALL, AND WITH REGIONAL ENLARGEMENT IN SEVERAL RIGHT HEMISPHERIC CORTICAL AND SUBCORTICAL BRAIN REGIONS THAT ARE ASSOCIATED WITH SUSTAINED ATTENTION, SELF-CONTROL, COMPASSION AND INTEROCEPTIVE PERCEPTION. THE INCREASED GREY MATTER VOLUME IN THESE ATTENTION AND SELF-CONTROL MEDIATING REGIONS SUGGESTS USE-DEPENDENT ENLARGEMENT WITH REGULAR PRACTICE OF THIS MEDITATION. 2016 16 1286 41 GRAY MATTER AND FUNCTIONAL CONNECTIVITY IN ANTERIOR CINGULATE CORTEX ARE ASSOCIATED WITH THE STATE OF MENTAL SILENCE DURING SAHAJA YOGA MEDITATION. SOME MEDITATION TECHNIQUES TEACH THE PRACTITIONER TO ACHIEVE THE STATE OF MENTAL SILENCE. THE AIM OF THIS STUDY WAS TO INVESTIGATE BRAIN REGIONS THAT ARE ASSOCIATED WITH THEIR VOLUME AND FUNCTIONAL CONNECTIVITY (FC) WITH THE DEPTH OF MENTAL SILENCE IN LONG-TERM PRACTITIONERS OF SAHAJA YOGA MEDITATION. TWENTY-THREE LONG-TERM PRACTITIONERS OF THIS MEDITATION WERE SCANNED USING MAGNETIC RESONANCE IMAGING. IN ORDER TO IDENTIFY THE NEURAL CORRELATES OF THE DEPTH OF MENTAL SILENCE, WE TESTED WHICH GRAY MATTER VOLUMES (GMV) WERE CORRELATED WITH THE DEPTH OF MENTAL SILENCE AND WHICH REGIONS THESE AREAS WERE FUNCTIONALLY CONNECTED TO UNDER A MEDITATION CONDITION. GMV IN MEDIAL PREFRONTAL CORTEX INCLUDING ROSTRAL ANTERIOR CINGULATE CORTEX WERE POSITIVELY CORRELATED WITH THE SUBJECTIVE PERCEPTION OF THE DEPTH OF MENTAL SILENCE INSIDE THE SCANNER. FURTHERMORE, THERE WAS SIGNIFICANTLY INCREASED FC BETWEEN THIS AREA AND BILATERAL ANTERIOR INSULA/PUTAMEN DURING A MEDITATION-STATE SPECIFICALLY, WHILE DECREASED CONNECTIVITY WITH THE RIGHT THALAMUS/PARAHIPPOCAMPAL GYRUS WAS PRESENT DURING THE MEDITATION-STATE AND THE RESTING-STATE. THE CAPACITY OF LONG-TERM MEDITATORS TO ESTABLISH A DURABLE STATE OF MENTAL SILENCE INSIDE AN MRI SCANNER WAS ASSOCIATED WITH LARGER GRAY MATTER VOLUME IN A MEDIAL FRONTAL REGION THAT IS CRUCIAL FOR TOP-DOWN COGNITIVE, EMOTION AND ATTENTION CONTROL. THIS IS FURTHERMORE CORROBORATED BY INCREASED FC OF THIS REGION DURING THE MEDITATION-STATE WITH BILATERAL ANTERIOR INSULA/PUTAMEN, WHICH ARE IMPORTANT FOR INTEROCEPTION, EMOTION, AND ATTENTION REGULATION. THE FINDINGS HENCE SUGGEST THAT THE DEPTH OF MENTAL SILENCE IS ASSOCIATED WITH MEDIAL FRONTO-INSULAR-STRIATAL NETWORKS THAT ARE CRUCIAL FOR TOP-DOWN ATTENTION AND EMOTIONAL CONTROL. 2018 17 1639 19 MODULATION OF IMMUNE RESPONSES IN STRESS BY YOGA. STRESS IS A CONSTANT FACTOR IN TODAY'S FASTPACED LIFE THAT CAN JEOPARDIZE OUR HEALTH IF LEFT UNCHECKED. IT IS ONLY IN THE LAST HALF CENTURY THAT THE ROLE OF STRESS IN EVERY AILMENT FROM THE COMMON COLD TO AIDS HAS BEEN EMPHASIZED, AND THE MECHANISMS INVOLVED IN THIS PROCESS HAVE BEEN STUDIED. STRESS INFLUENCES THE IMMUNE RESPONSE PRESUMABLY THROUGH THE ACTIVATION OF THE HYPOTHALAMIC-PITUITARY ADRENAL AXIS, HYPOTHALAMIC PITUITARY-GONADAL AXIS, AND THE SYMPATHETIC-ADRENAL-MEDULLARY SYSTEM. VARIOUS NEUROTRANSMITTERS, NEUROPEPTIDES, HORMONES, AND CYTOKINES MEDIATE THESE COMPLEX BIDIRECTIONAL INTERACTIONS BETWEEN THE CENTRAL NERVOUS SYSTEM (CNS) AND THE IMMUNE SYSTEM. THE EFFECTS OF STRESS ON THE IMMUNE RESPONSES RESULT IN ALTERATIONS IN THE NUMBER OF IMMUNE CELLS AND CYTOKINE DYSREGULATION. VARIOUS STRESS MANAGEMENT STRATEGIES SUCH AS MEDITATION, YOGA, HYPNOSIS, AND MUSCLE RELAXATION HAVE BEEN SHOWN TO REDUCE THE PSYCHOLOGICAL AND PHYSIOLOGICAL EFFECTS OF STRESS IN CANCERS AND HIV INFECTION. THIS REVIEW AIMS TO DISCUSS THE EFFECT OF STRESS ON THE IMMUNE SYSTEM AND EXAMINE HOW RELAXATION TECHNIQUES SUCH AS YOGA AND MEDITATION COULD REGULATE THE CYTOKINE LEVELS AND HENCE, THE IMMUNE RESPONSES DURING STRESS. 2008 18 2371 32 WHAT HAS NEUROIMAGING TAUGHT US ON THE NEUROBIOLOGY OF YOGA? A REVIEW. YOGA IS BECOMING INCREASINGLY POPULAR WORLDWIDE, WITH SEVERAL IMPLICATED PHYSICAL AND MENTAL BENEFITS. HERE WE PROVIDE A COMPREHENSIVE AND CRITICAL REVIEW OF THE RESEARCH GENERATED FROM THE EXISTING NEUROIMAGING LITERATURE IN STUDIES OF YOGA PRACTITIONERS. WE REVIEWED 34 INTERNATIONAL PEER-REVIEWED NEUROIMAGING STUDIES OF YOGA USING MAGNETIC RESONANCE IMAGING (MRI), POSITRON EMISSION TOMOGRAPHY (PET), OR SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY (SPECT): 11 MORPHOLOGICAL AND 26 FUNCTIONAL STUDIES, INCLUDING THREE STUDIES THAT WERE CLASSIFIED AS BOTH MORPHOLOGICAL AND FUNCTIONAL. CONSISTENT FINDINGS INCLUDE INCREASED GRAY MATTER VOLUME IN THE INSULA AND HIPPOCAMPUS, INCREASED ACTIVATION OF PREFRONTAL CORTICAL REGIONS, AND FUNCTIONAL CONNECTIVITY CHANGES MAINLY WITHIN THE DEFAULT MODE NETWORK. THERE IS QUITE SOME VARIABILITY IN THE NEUROIMAGING FINDINGS THAT PARTIALLY REFLECTS DIFFERENT YOGA STYLES AND APPROACHES, AS WELL AS SAMPLE SIZE LIMITATIONS. DIRECT COMPARATOR GROUPS SUCH AS PHYSICAL ACTIVITY ARE SCARCELY USED SO FAR. FINALLY, HYPOTHESES ON THE UNDERLYING NEUROBIOLOGY DERIVED FROM THE IMAGING FINDINGS ARE DISCUSSED IN THE LIGHT OF THE POTENTIAL BENEFICIAL EFFECTS OF YOGA. 2020 19 1595 21 MEDITATION AND YOGA-ASSISTED ALTERATION OF DIETARY BEHAVIOR AS A USEFUL STRATEGY FOR LIMITING ZOONOTIC PANDEMICS: A NOVEL INSIGHT. VEGETARIAN DIETS ARE KNOWN TO HAVE SIGNIFICANT POSITIVE EFFECTS ON PERSONAL AND PLANETARY HEALTH AND ARE LIKELY TO CURB ZOONOTIC INFECTION TRANSMISSION. WE PROPOSE THAT MINIMIZING MEAT CONSUMPTION SHOULD BECOME AN ESSENTIAL DIETARY SHIFT IN THE POST-COVID-19 ERA. TO DATE, HOWEVER, THERE IS LIMITED KNOWLEDGE CONCERNING SUITABLE METHODS THAT COULD CATALYZE THIS CHANGE ON A GLOBAL SCALE. MEDITATION AND YOGA ARE PRACTICAL AND EASY TO IMPLEMENT PSYCHOMODULATORY STRATEGIES THAT CAN NATURALLY TRIGGER VEGETARIANISM AND RELATED EATING BEHAVIORS, LOWERING OUR RELIANCE ON ANIMAL MEAT. DECREASING DEPENDENCE ON ANIMAL MEAT REDUCES THE NEED FOR ANIMAL MARKETS AND MAY SUBSTANTIALLY MINIMIZE THE LIKELIHOOD OF SPILLOVER (PASSAGE OF VIRUSES FROM ANIMAL RESERVOIRS INTO HUMAN POPULATIONS). GLOBAL IMPLEMENTATION OF THESE STRATEGIES, IN OUR OPINION, CAN ADD TO SPIRITUAL WISDOM, COMPASSION, AND COOPERATIVE HUMAN BEHAVIOR, THUS REDUCING THE ENCROACHMENT OF WILD-LIFE RESERVES AND ANIMAL EXPLOITATION. THE APPLICATION OF THESE ANCIENT INDIAN APPROACHES REPRESENTS A NOVEL AND FOCUSED STRATEGY TOWARD CURBING ZOONOTIC PANDEMICS. KEYWORDS: CORONAVIRUS DISEASE-19, MEAT-EATING, MEDITATION, PANDEMICS, VIRAL SPILLOVER, YOGA. 2020 20 2239 16 THE IMPORTANCE OF RESEARCH LITERACY FOR YOGA THERAPISTS. EVIDENCE-INFORMED PRACTICE (EIP) UTILIZES THE THREE COMPONENTS OF EXPERT OPINION, RESEARCH EVIDENCE, AND CLIENT VALUES. IT IS A RECOMMENDED TRAINING COMPETENCY FOR INTEGRATIVE HEALTH PRACTITIONERS IN DIVERSE FIELDS, SUCH AS ACUPUNCTURE AND MASSAGE THERAPY. RESEARCH LITERACY (RL) IS A NECESSARY PRE-REQUISITE TO EIP. MANY YOGA THERAPISTS HAVE LIMITED TRAINING IN THESE SKILLS, WHICH NEGATIVELY IMPACTS INTER-PROFESSIONAL COMMUNICATION AND COLLABORATION, AS WELL AS FURTHER ADVANCEMENT OF YOGA THERAPY RESEARCH AND PRACTICE. IN THIS ARTICLE, WE PROPOSE INCLUSION OF RL AND EIP IN THE TRAINING OF YOGA THERAPISTS. BENEFITS FOR CLIENT CARE, COLLABORATIVE CARE, AND THE FIELD OF YOGA THERAPY ARE DISCUSSED. 2017