1 1690 254 OXIDATIVE STRESS INDUCED DAMAGE TO PATERNAL GENOME AND IMPACT OF MEDITATION AND YOGA - CAN IT REDUCE INCIDENCE OF CHILDHOOD CANCER? BACKGROUND: SPERM DNA DAMAGE IS UNDERLYING AETIOLOGY OF POOR IMPLANTATION AND PREGNANCY RATES BUT ALSO AFFECTS HEALTH OF OFFSPRING AND MAY ALSO RESULT IN DENOVO MUTATIONS IN GERM LINE AND POST FERTILIZATION. THIS MAY RESULT IN COMPLEX DISEASES, POLYGENIC DISORDERS AND CHILDHOOD CANCERS. CHILDHOOD CANCER LIKE RETINOBLASTOMA (RB) IS MORE PREVALENT IN DEVELOPING COUNTRIES AND THE INCIDENCE OF RB HAS INCREASED MORE THAN THREE FOLD IN INDIA IN THE LAST DECADE. RECENT STUDIES HAVE DOCUMENTED INCREASED INCIDENCE OF CANCERS IN CHILDREN BORN TO FATHERS WHO CONSUME ALCOHOL IN EXCESS AND TOBACCO OR WHO WERE CONCEIVED BY ASSISTED CONCEPTION. THE AETIOLOGY OF CHILDHOOD CANCER AND INCREASED DISEASE BURDEN IN THESE CHILDREN IS LIN KED TO OXIDATIVE STRESS (OS) AND OXIDATIVE DNA DAMAGE( ODD) IN SPERM OF THEIR FATHERS. THOUGH SEVERAL ANTIOXIDANTS ARE IN USE TO COMBAT OXIDATIVE STRESS, THE EFFECT OF MAJORITY OF THESE FORMULATIONS ON DNA IS NOT KNOWN. YOGA AND MEDITATION CAUSE SIGNIFICANT DECLINE IN OS AND ODD AND AID IN REGULATING OS LEVELS SUCH THAT REACTIVE OXYGEN SPEUES MEDITATED SIGNAL TRANSDUCTION, GENE EXPRESSION AND SEVERAL OTHER PHYSIOLOGICAL FUNCTIONS ARE NOT DISRUPTED. THUS, THIS STUDY AIMED TO ANALYZE SPERM ODD AS A POSSIBLE ETIOLOGICAL FACTOR IN CHILDHOOD CANCER AND ROLE OF SIMPLE LIFE STYLE INTERVENTIONS LIKE YOGA AND MEDITATION IN SIGNIFICANTLY DECREASING SEMINAL OXIDATIVE STRESS AND OXIDATIVE DNA DAMAGE AND THEREBY DECREASING INCIDENCE OF CHILDHOOD CANCERS. MATERIALS AND METHODS: A TOTAL OF 131 FATHERS OF CHILDREN WITH RB (NON-FAMILIAL SPORADIC HERITABLE) AND 50 CONTROLS (FATHERS OF HEALTHY CHILDREN) WERE RECRUITED AT A TERTIARY CENTER IN INDIA. SPERM PARAMETERS AS PER WHO 2010 GUIDELINES AND REACTIVE OXYGEN SPECIES (ROS), DNA FRAGMENTATION INDEX (DFI), 8-HYDROXY-2'-DEOXY GUANOSINE (8-OHDG) AND TELOMERE LENGTH WERE ESTIMATED AT DAY 0, AND AFTER 3 AND 6 MONTHS OF INTERVENTION. WE ALSO EXAMINED THE COMPLIANCE WITH YOGA AND MEDITATION PRACTICE AND SMOKING STATUS AT EACH FOLLOW-UP. RESULTS: THE SEMINAL MEAN ROS LEVELS (P<0.05), SPERM DFI (P<0.001), 8-OHDG (P<0.01) LEVELS WERE SIGNIFICANTLY HIGHER IN FATHERS OF CHILDREN WITH RB, AS COMPARED TO CONTROLS AND THE RELATIVE MEAN TELOMERE LENGTH IN THE SPERM WAS SHORTER. LEVELS OF ROS WERE SIGNIFICANTLY REDUCED IN TOBACCO USERS (P<0.05) AS WELL AS IN ALCOHOLICS (P<0.05) AFTER INTERVENTION. DFI REDUCED SIGNIFICANTLY (P<0.05) AFTER 6 MONTHS OF YOGA AND MEDITATION PRACTICE IN ALL GROUPS. THE LEVELS OF OXIDATIVE DNA DAMAGE MARKER 8-OHDG WERE REDUCED SIGNIFICANTLY AFTER 3 MONTHS (P<0.05) AND 6 MONTHS (P<0.05) OF PRACTICE. CONCLUSIONS: OUR RESULTS SUGGEST THAT OS AND ODD DNA MAY CONTRIBUTE TO THE DEVELOPMENT OF CHILDHOOD CANCER. THIS MAY BE DUE TO ACCUMULATION OF OXIDIZED MUTAGENIC BASE 8OHDG , AND ELEVATED MDA LEVELS WHICH RESULTS IN MDA DIMERS WHICH ARE ALSO MUTAGENIC, ABERRANT METHYLATION PATTERN, ALTERED GENE EXPRESSION WHICH AFFECT CELL PROLIFERATION AND SURVIVAL THROUGH ACTIVATION OF TRANSCRIPTION FACTORS. INCREASED MT DNA MUTATIONS AND ABERRANT REPAIR OF MT AND NUCLEAR DNA DUE TO HIGHLY TRUNCATRED DNA REPAIR MECHANISMS ALL CONTRIBUTE TO SPERM GENOME HYPERMUTABILITY AND PERSISTANT OXIDATIVE DNA DAMAGE. OXIDATIVE STRESS IS ALSO ASSOCIATED WITH GENOME WIDE HYPOMETHYLATION, TELOMERE SHORTENING AND MITOCHONDRIAL DYSFUNCTION LEADING TO GENOME HYPERMUTABILITY AND INSTABILITY. TO THE BEST OF OUR KNOWLEDGE, THIS IS THE FIRST STUDY TO REPORT DECLINE IN OS AND ODD AND IMPROVEMENT IN SPERM DNA INTEGRITY FOLLOWING ADOPTION OF MEDITATION AND YOGA BASED LIFE STYLE MODIFICATION.THIS MAY REDUCE DISEASE BURDEN IN NEXT GENERATION AND REDUCE INCIDENCE OF CHILDHOOD CANCERS.	2016	

2 1589  60 MEDITATION & YOGA: IMPACT ON OXIDATIVE DNA DAMAGE & DYSREGULATED SPERM TRANSCRIPTS IN MALE PARTNERS OF COUPLES WITH RECURRENT PREGNANCY LOSS. BACKGROUND & OBJECTIVES: RECURRENT PREGNANCY LOSS (RPL) IS ONE OF THE DEVASTATING COMPLICATIONS OF PREGNANCY AND CURRENT FOCUS LIES IN ADDRESSING THE MANAGEMENT OF PATERNAL FACTORS. DYSREGULATION IN SELECTIVE TRANSCRIPTS DELIVERED TO OOCYTE AT FERTILIZATION CAN RESULT IN PREGNANCY LOSSES AND ADVERSELY AFFECT EMBRYOGENESIS. THE OBJECTIVE OF THIS STUDY WAS TO ASSESS THE EFFECT OF YOGA-BASED LIFESTYLE INTERVENTION (YBLI) ON SEMINAL OXIDATIVE STRESS (OS), DNA DAMAGE AND SPERMATOZOAL TRANSCRIPT LEVELS. METHODS: THE PRESENT STUDY WAS A PART OF A PROSPECTIVE ONGOING EXPLORATORY STUDY AND 30 MALE PARTNERS OF COUPLES WITH RPL WERE INCLUDED FROM AUGUST 2016 TO JUNE 2017. SEMEN SAMPLES WERE OBTAINED AT BASELINE AND AT THE END OF YBLI (21 DAYS). GENE EXPRESSION ANALYSIS WAS PERFORMED BY QUANTITATIVE POLYMERASE CHAIN REACTION ON SPERMATOZOAL FOXG1, SOX3, OGG1, PARP1, RPS6, RBM9, RPS17 AND RPL29. THE LEVELS OF SEMINAL OS AND SPERM DNA DAMAGE WAS ASSESSED BY MEASURING LEVELS OF REACTIVE OXYGEN SPECIES (ROS) BY CHEMILUMINESCENCE AND DNA FRAGMENTATION INDEX (DFI) BY SPERM CHROMATIN STRUCTURE ASSAY. RESULTS: SOX3, OGG1 AND PARP1 WERE OBSERVED TO BE UPREGULATED, WHILE FOXG1, RPS6, RBM9, RPS17 AND RPL29 SHOWED DOWNREGULATION. A SIGNIFICANT REDUCTION IN ROS LEVELS, AN INCREASE IN SPERM MOTILITY, SPERM COUNT (DONE TWICE) AND A DECREASE IN DFI WAS SEEN AFTER YBLI. INTERPRETATION & CONCLUSIONS: ADOPTING YBLI MAY HELP IN A SIGNIFICANT DECLINE IN OXIDATIVE DNA DAMAGE AND NORMALIZATION OF SPERM TRANSCRIPT LEVELS. THIS MAY NOT ONLY IMPROVE PREGNANCY OUTCOMES BUT ALSO IMPROVE THE HEALTH TRAJECTORY OF THE OFFSPRING.	2018	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
3 2514  39 YOGA CAN IMPROVE ASSISTED REPRODUCTION TECHNOLOGY OUTCOMES IN COUPLES WITH INFERTILITY. CONTEXT: DEPENDING ON THE CAUSE OF THE INFERTILITY, NONSURGICAL OR SURGICAL TREATMENTS MAY BE USED TO TREAT MEN AND WOMEN WITH INFERTILITY. DESPITE IMPROVED OUTCOMES DUE TO MEDICAL ADVANCES, ASSISTED REPRODUCTIVE TECHNOLOGY (ART) FOR COUPLES WITH INFERTILITY IS SOMETIMES UNSUCCESSFUL. SUCCESS MAY BE AFFECTED BY THE PATIENT'S SOCIAL, PSYCHOLOGICAL, AND PHYSICAL STATUS. OBJECTIVE: THE STUDY EXAMINED THE EFFECTS OF YOGA-INCLUDING ASANAS (YOGA POSES), PRANAYAMA (PROPER BREATHING), SHAVASANA, AND MEDITATION-ON MALE AND FEMALE FERTILITY AND ART OUTCOMES. DESIGN: THE RESEARCH TEAM PERFORMED A LITERATURE REVIEW, ELECTRONICALLY SEARCHING FOR ARTICLES PUBLISHED BETWEEN JANUARY 1978 AND JANUARY 2016 IN THE PUBMED, SCOPUS, SCIENCEDIRECT, AND GOOGLE SCHOLAR DATABASES. SETTING: THE STUDY TOOK PLACE AT THE REPRODUCTIVE BIOTECHNOLOGY RESEARCH CENTER AT THE AVICENNA RESEARCH INSTITUTE AT THE ACADEMIC CENTER FOR EDUCATION, CULTURE, AND RESEARCH (TEHRAN, IRAN). PARTICIPANTS: PARTICIPANTS WERE COUPLES WITH INFERTILITY TAKING PART IN 87 REVIEWED STUDIES. INTERVENTION: YOGA WAS THE INTERVENTION. OUTCOME MEASURES: THE OUTCOME MEASURES COMPRISED FERTILITY FACTORS IN MALES AND FEMALES, FERTILITY RATE, AND ART SUCCESS RATE. RESULTS: THE REVIEWED STUDIES SHOWED THAT YOGA CAN PROVIDE STRESS MANAGEMENT FOR PATIENTS WITH INFERTILITY, WITH BENEFICIAL EFFECTS ON FERTILITY, HELPING COUPLES GIVE BIRTH. THEY FOUND THAT YOGA ALSO COULD REDUCE PAIN; DECREASE DEPRESSION, ANXIETY, AND STRESS; REDUCE THE RATE OF ASSISTED VAGINAL DELIVERY; AND IMPROVE FETAL OUTCOMES. CONCLUSIONS: YOGA CAN HELP COUPLES OVERCOME INFERTILITY AND INCREASE THE ART SUCCESS RATE BY IMPROVING THE PHYSIOLOGICAL AND PSYCHOLOGICAL STATES OF BOTH MEN AND WOMEN.	2018	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
4 1989  47 SPERM METHYLOME ALTERATIONS FOLLOWING YOGA-BASED LIFESTYLE INTERVENTION IN PATIENTS OF PRIMARY MALE INFERTILITY: A PILOT STUDY. A MAJORITY OF THE CASES OF PRIMARY MALE INFERTILITY ARE IDIOPATHIC WITH THE UNDERLYING MOLECULAR MECHANISMS CONTRIBUTING TO THE PATHOPHYSIOLOGY AS YET UNKNOWN. EFFECTS OF THE ENVIRONMENT CAN ALTER THE SPERM EPIGENOME THEREBY IMPACTING MALE REPRODUCTIVE HEALTH. EPIGENETIC MECHANISMS ARE CRUCIAL TO UNDERSTANDING HEALTH AND DISEASE, AND METHYLOME ALTERATIONS ARE NOW KNOWN TO HAVE FAR-REACHING CLINICAL IMPLICATIONS. HERE, WE REPORT THE RESULTS FROM OUR PILOT STUDY, A FIRST OF ITS KIND ANALYSIS OF THE EFFECT OF THE TRADITIONAL PRACTICE OF YOGA ON HUMAN SPERM QUALITY. WE FIND MARKED IMPROVEMENT IN SPERM CHARACTERISTICS IN PATIENTS OF IDIOPATHIC MALE INFERTILITY FOLLOWING A SUPERVISED 21-DAY YOGA REGIMEN. FURTHERMORE, NEXT-GENERATION SEQUENCING-BASED METHYLOME ANALYSIS REVEALS ALTERATIONS IN THE SPERM EPIGENOME OF THESE PATIENTS. WE FIND THAT THE PRACTICE OF YOGA IS ASSOCIATED WITH DNA METHYLATION CHANGES AT NEARLY 400 GENES, 147 OF WHICH WERE HYPERMETHYLATED WHILE 229 WERE HYPOMETHYLATED. THESE INCLUDED PROMOTERS OF SEVERAL GENES LINKED TO MAINTENANCE OF FERTILITY AND GENOMIC INTEGRITY. THIS NOVEL PIECE OF WORK DRAWS A DIRECT LINK BETWEEN POSITIVE LIFESTYLE PRACTICES AND MALE REPRODUCTIVE HEALTH.	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
5  141  32 A PROSPECTIVE STUDY USING HATHA YOGA FOR STRESS REDUCTION AMONG WOMEN WAITING FOR IVF TREATMENT. YOGA HAS BEEN FOUND TO BE EFFECTIVE IN TREATING ANXIETY AND DEPRESSION, REDUCING STRESS AND IMPROVING THE OVERALL QUALITY OF LIFE IN THE GENERAL POPULATION. MINIMAL RESEARCH IS AVAILABLE ON THE EFFECT OF STRESS-MANAGEMENT PROGRAMMES WITH IVF PATIENTS. OWING TO THE DIVERSITY OF CONDITIONS TREATED, THE POOR QUALITY OF MOST STUDIES, AND THE DIFFERENT ASSESSMENT TOOLS USED TO EVALUATE THE PSYCHOLOGICAL STATE, IT IS DIFFICULT TO DRAW DEFINITE CONCLUSIONS. PREVIOUS STUDIES HAVE USED DIFFERENT MIND-BODY INTERVENTIONS AND GENERAL MEASURES OF STRESS WITHOUT EVALUATION OF SPECIFIC STRESSES KNOWN TO RESULT FROM INFERTILITY AND ITS TREATMENT USING STANDARDIZED MEASURES. IN THIS SINGLE-CENTRE STUDY, 49 INFERTILE WOMEN WERE RECRUITED TO PARTICIPATE IN A 6-WEEK YOGA CLASS DURING 2013 WHILE AWAITING THEIR IVF TREATMENT. STUDY PARTICIPANTS WERE ASKED TO COMPLETE STANDARDIZED QUESTIONNAIRES ASSESSING FERTILITY-RELATED QUALITY OF LIFE (FERTIQOL), MARITAL HARMONY (DYADIC ADJUSTMENT SCALE [DAS]), STATE AND TRAIT ANXIETY (STATE-TRAIT ANXIETY INVENTORY [STAI]) AND DEPRESSION (BECK DEPRESSION INVENTORY [BDI]) BEFORE COMMENCING AND AFTER COMPLETING THE YOGA WORKSHOPS. ANXIETY, DEPRESSION AND FERTILITY-SPECIFIC QUALITY OF LIFE SHOWED IMPROVEMENT OVER TIME IN ASSOCIATION WITH PARTICIPATION IN A 6-WEEK YOGA PROGRAMME IN WOMEN AWAITING THEIR TREATMENT WITH IVF.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
6 2897  31 [EFFECTS OF A YOGA-FOCUSED PRENATAL PROGRAM ON STRESS, ANXIETY, SELF CONFIDENCE AND LABOR PAIN IN PREGNANT WOMEN WITH IN VITRO FERTILIZATION TREATMENT]. PURPOSE: THE PURPOSE OF THIS STUDY WAS TO IDENTIFY THE EFFECTS OF A YOGA-FOCUSED PRENATAL PROGRAM ON THE STRESS, ANXIETY, SELF CONFIDENCE AND LABOR PAIN OF PREGNANT WOMEN WHO HAD IN VITRO FERTILIZATION (IVF) TREATMENT. METHODS: A QUASI EXPERIMENTAL STUDY WITH A NON-EQUIVALENT CONTROL GROUP PRETEST-POSTTEST DESIGN WAS USED. THE DATA COLLECTION PERIOD AND MEDITATION PROGRAM WERE BETWEEN JANUARY 9 AND AUGUST 31, 2009. FORTY-SIX WOMEN WHO WERE PREGNANT FOLLOWING IVF, AND WERE BETWEEN 12-20 WEEKS GESTATION, PARTICIPATED IN THE STUDY (23 EXPERIMENTAL GROUP, 23 CONTROL GROUP). DATA WERE ANALYZED USING CHI-SQUARE TEST, MANN-WHITNEY U TEST, ANCOVA, AND CRONBACH'S ALPHA COEFFICIENTS WITH THE SPSS 12.0 FOR WINDOWS PROGRAM. RESULTS: ALTHOUGH THE SAMPLE SIZE WAS LIMITED, WOMEN WHO PARTICIPATED IN THE PROGRAM SHOWED STATISTICALLY SIGNIFICANT IMPROVEMENTS IN STRESS, ANXIETY, LABOR PAIN, AND LABOR CONFIDENCE FOR WOMEN PREGNANT AFTER IVF. CONCLUSION: THE RESULT INDICATE THAT THIS 12-WEEK YOGA-FOCUSED EDUCATIONAL PROGRAM CAN BE UTILIZED FOR WOMEN PREGNANT FOLLOWING IVF TO REDUCE THEIR STRESS, ANXIETY, AND LABOR PAIN, AND TO INCREASE DELIVERY CONFIDENCE. IT IS SUGGESTED THAT THE YOGA-FOCUSED EDUCATIONAL PROGRAM BE OFFERED TO EVERY PREGNANT WOMAN.	2012	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
7  842  37 EFFECT OF YOGA ON PSYCHOLOGICAL DISTRESS AMONG WOMEN RECEIVING TREATMENT FOR INFERTILITY. BACKGROUND: INFERTILITY AMONG WOMEN HAS BEEN ASSOCIATED WITH SIGNIFICANT PSYCHOLOGICAL DISTRESS, ANXIETY, AND DEPRESSION. YOGA THERAPY HAS BEEN FOUND TO BE USEFUL IN THE MANAGEMENT OF ANXIETY, DEPRESSION AND PSYCHOLOGICAL DISTRESS. AIM: TO REVIEW STUDIES ON THE EFFECTIVENESS OF YOGA IN REDUCING PSYCHOLOGICAL DISTRESS AND IMPROVING CLINICAL OUTCOMES AMONG WOMEN RECEIVING TREATMENT FOR INFERTILITY. METHODOLOGY: PUBMED, SCIENCEDIRECT, AND GOOGLE SCHOLAR DATABASES WERE SEARCHED FOR STUDIES USING THE FOLLOWING INCLUSION CRITERIA: STUDIES PUBLISHED IN ENGLISH, THOSE PUBLISHED BETWEEN 2000 AND 2018, PUBLISHED IN PEER-REVIEWED JOURNALS, AND THOSE WITH YOGA AS AN INTERVENTION. REVIEW ARTICLES, STUDIES WITHOUT ANY YOGA INTERVENTIONS FOR INFERTILITY, AND MALE INFERTILITY WERE EXCLUDED. THE KEYWORDS INCLUDED FOR THE LITERATURE SEARCH WERE: YOGA, MINDFULNESS, RELAXATION TECHNIQUE, STRESS, DISTRESS, ANXIETY, INFERTILITY, IN VITRO FERTILIZATION (IVF), AND ASSISTED REPRODUCTIVE TECHNOLOGY (ART). RESULTS: THREE STUDIES SATISFIED THE SELECTION CRITERIA. TWO STUDIES INVOLVED HATHA YOGA INTERVENTION AND ONE STUDY USED STRUCTURED YOGA PROGRAM. THE VARIABLES ASSESSED IN THESE STUDIES WERE: (1) ANXIETY, (2) DEPRESSION, (3) EMOTIONAL DISTRESS, AND (4) FERTILITY-RELATED QUALITY OF LIFE. ALL THE STUDIES REPORTED AN IMPROVEMENT IN THE ANXIETY SCORES AFTER YOGA INTERVENTION. CONCLUSION: YOGA THERAPY MAY BE POTENTIALLY USEFUL IN IMPROVING ANXIETY SCORES AMONG WOMEN SUFFERING FROM INFERTILITY. MORE STUDIES ARE NEEDED IN THIS AREA TO ESTABLISH ROLE OF YOGA AS AN ADJUVANT DURING THE TREATMENT OF INFERTILITY.	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
8 2111  31 THE EFFECT OF YOGA ON STRESS LEVEL IN INFERTILE WOMEN. PURPOSE: THE AIM OF THE PRESENT STUDY WAS TO EXAMINE THE EFFECTS OF PLANNED YOGA PRACTICES ON STRESS LEVELS IN INFERTILE WOMEN. DESIGN AND METHODS: THIS RANDOMIZED CONTROLLED STUDY INCLUDED 128 VOLUNTEER WOMEN WHO WERE REGISTERED AT A PRIVATE IN VITRO FERTILIZATION (IVF) CLINIC AND RECEIVED INFERTILITY TREATMENT. THE PATIENTS IN THE EXPERIMENTAL GROUP TOOK PART IN THE YOGA PROGRAM TWICE A WEEK FOR 6 WEEKS. A PERSONAL INFORMATION FORM AND THE COPENHAGEN MULTI-CENTER PSYCHOSOCIAL INFERTILITY (COMPI) FERTILITY PROBLEM STRESS SCALE WERE USED TO COLLECT DATA. FINDINGS: THE DIFFERENCES BETWEEN THE MEAN SCORES OF THE CONTROL AND EXPERIMENTAL GROUPS ON THE COMPI FERTILITY PROBLEM STRESS SCALE AT PRE- AND POSTTESTS WERE STATISTICALLY SIGNIFICANT (P < 0.05). PRACTICE IMPLICATIONS: BECAUSE YOGA PRACTICES MAY BE EFFECTIVE IN REDUCING STRESS IN INFERTILE WOMEN, THESE APPLICATIONS CAN BE PERFORMED BEFORE TREATMENT. IT MAY REDUCE PATIENTS' STRESS AND INCREASE THE SUCCESS OF THE TREATMENT. THESE FINDINGS INDICATE THAT YOGA COULD REDUCE STRESS LEVELS IN INFERTILE WOMEN.	2019	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
9 1308  42 HATHA-YOGA AS A PSYCHOLOGICAL ADJUVANT FOR WOMEN UNDERGOING IVF: A PILOT STUDY. OBJECTIVES: TO EVALUATE THE INFLUENCE OF HATHA-YOGA (HY) PRACTICE ON DISTRESS OF WOMEN BEFORE STARTING THEIR FIRST IN VITRO FERTILIZATION (IVF) CYCLE. STUDY DESIGN: WE OFFERED 143 CONSECUTIVE WOMEN WITH COUPLE INFERTILITY THE OPPORTUNITY TO ATTEND A FREE HY COURSE LASTING 3 MONTHS AS A PSYCHOLOGICAL SUPPORT BEFORE STARTING THEIR FIRST IVF CYCLE. ALL WOMEN WERE ASKED TO COMPLETE THE STATE-TRAIT ANXIETY INVENTORY-Y1 (STAY-Y1), EDINBURGH DEPRESSION SCALE (EDS) AND GENERAL HEALTH QUESTIONNAIRE-12 (GHQ-12) AT BASELINE (T1) AND AFTER 3 MONTHS (T2), TO EVALUATE SYMPTOMS OF ANXIETY, DEPRESSION AND DISTRESS, RESPECTIVELY. RESULTS: OF THE 143 WOMEN, 120 COMPLETED ALL THREE QUESTIONNAIRES. OF THESE, 45 ATTENDED THE HY COURSE AND 75 DID NOT. AT T1, EDS AND GHQ-12 SCORES WERE SIGNIFICANTLY HIGHER IN THE HY GROUP THAN IN THE NON-HY GROUP. THERE WERE NO GROUP DIFFERENCES IN STAI-Y1 SCORES. AT T2 THERE WERE NO GROUP DIFFERENCES. WHEN, IN EACH GROUP, THE SCORE OF EACH QUESTIONNAIRE AT T1 WAS COMPARED TO THE SCORE AT T2, A SIGNIFICANT T1 TO T2 REDUCTION WAS OBSERVED IN THE HY GROUP (P<0.0001 FOR STAY-Y1 AND GHQ-12, P<0.001 FOR EDS). CONCLUSIONS: OUR DATA SUGGEST THAT WOMEN WHO ARE MORE DISTRESSED ARE MORE LIKELY TO ACCEPT PSYCHOLOGICAL SUPPORT BEFORE STARTING AN IVF CYCLE AND THAT IN THESE WOMEN HY PRACTICE IS ASSOCIATED WITH DISTRESS REDUCTION.	2014	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
10 2652  52 YOGA IMPROVES MITOCHONDRIAL HEALTH AND REDUCES SEVERITY OF AUTOIMMUNE INFLAMMATORY ARTHRITIS: A RANDOMIZED CONTROLLED TRIAL. BACKGROUND: OXIDATIVE STRESS (OS) AND MITOCHONDRIAL ALTERATIONS HAVE BEEN IMPLICATED IN THE PATHOGENESIS OF RHEUMATOID ARTHRITIS (RA). VARIOUS ENVIRONMENTAL TRIGGERS LIKE AIR POLLUTANTS, SMOKING, UNHEALTHY SOCIAL HABITS AND SEDENTARY LIFESTYLE INDUCE OS, WHICH MAY COMPROMISE MITOCHONDRIAL INTEGRITY. THIS TRIAL WAS DESIGNED TO EXPLORE THE EFFECT OF 8-WEEKS YOGA PRACTICE ON MITOCHONDRIAL HEALTH AND DISEASE SEVERITY IN AN ACTIVE RA GROUP COMPARED WITH A USUAL-CARE CONTROL GROUP. METHODS: A TOTAL OF 70 SUBJECTS WERE RANDOMIZED INTO TWO GROUPS: YOGA GROUP AND NON-YOGA GROUP. MITOCHONDRIAL HEALTH WAS ASSESSED BY CALCULATION OF MITOCHONDRIAL DNA COPY NUMBER (MTDNA-CN), OS MARKERS, MITOCHONDRIAL ACTIVITY, MITOCHONDRIAL MEMBRANE POTENTIAL (DELTAPSIM), CIRCADIAN RHYTHM MARKERS AND TRANSCRIPTS ASSOCIATED WITH MITOCHONDRIAL INTEGRITY: AMPK, TIMP-1, KLOTHO, SIRT-1, AND TFAM. PARAMETERS OF DISEASE ACTIVITY AND DISABILITY QUOTIENT WERE ALSO ASSESSED BY DISEASE ACTIVITY SCORE - ERYTHROCYTE SEDIMENTATION RATE (DAS28-ESR) AND HEALTH ASSESSMENT QUESTIONNAIRE-DISABILITY INDEX (HAQ-DI), RESPECTIVELY. RESULTS: IN YOGA GROUP, THERE WAS A SIGNIFICANT UPREGULATION OF MTDNA-CN, MITOCHONDRIAL ACTIVITY MARKERS, DELTAPSIM, AND TRANSCRIPTS THAT MAINTAIN MITOCHONDRIAL INTEGRITY AFTER 8-WEEKS OF YOGA. THERE WAS OPTIMIZATION OF OS MARKERS, AND CIRCADIAN RHYTHM MARKERS POST 8-WEEKS PRACTICE OF YOGA. YOGA GROUP PARTICIPANTS SHOWED SIGNIFICANT IMPROVEMENTS IN DAS28-ESR (P < 0.05) AND HAQ-DI (P < 0.05) OVER THE NON-YOGA GROUP. CONCLUSION: ADOPTION OF YOGA BY RA PATIENTS HOLDS THE KEY TO ENHANCE MITOCHONDRIAL HEALTH, IMPROVE CIRCADIAN RHYTHM MARKERS, OS MARKER REGULATION, UPREGULATION OF TRANSCRIPTS THAT MAINTAIN MITOCHONDRIAL INTEGRITY, REDUCE DISEASE ACTIVITY AND ITS ASSOCIATED CONSEQUENCES ON HEALTH OUTCOME AND HENCE CAN BE BENEFICIAL AS AN ADJUNCT THERAPY.	2021	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
11  840  42 EFFECT OF YOGA ON POLYCYSTIC OVARIAN SYNDROME: A SYSTEMATIC REVIEW. POLYCYSTIC OVARIAN SYNDROME (PCOS) IS NOT A DISEASE BUT A MERE SYNDROME. MANY RESEARCHERS HAVE STUDIED POLYCYSTIC OVARIAN SYNDROME AND FOUND THAT THERE IS NO PROPER CAUSE OF THAT, IT MAY OCCUR DUE TO HORMONAL IMBALANCE OR STRESS, OR DUE TO A SEDENTARY LIFESTYLE. THE RATE OF POLYCYSTIC OVARIAN SYNDROME IN INDIAN WOMEN HAS BEEN INCREASING RAPIDLY. THE SYMPTOMS INCLUDE ACNE, WEIGHT GAIN, HIRSUTISM, DIFFICULTIES IN FERTILITY, IRREGULAR OR INFREQUENT PERIODS, IMMATURE OVARIAN EGGS THAT DO NOT OVULATE, MULTIPLE CYSTS IN THE OVARY. IF LEFT UNTREATED, IT MAY BECOME THE CAUSE FOR HEART DISEASES, DIABETES, HYPERTENSION, INFERTILITY, AND EVEN CANCER. THERE ARE VARIETIES OF MEDICAL TREATMENTS AVAILABLE TO TREAT POLYCYSTIC OVARIAN SYNDROME BUT THEY HAVE A TEMPORARY EFFECT AND IF TAKEN FOR A LONG TIME THEN IT MAY LEAD TO SERIOUS SIDE EFFECTS. YOGA HAS PROVEN EFFECTS IN REDUCING AND MANAGING THE SYMPTOMS OF POLYCYSTIC OVARIAN SYNDROME MORE EFFECTIVELY ALONG WITH MEDICINE. THIS REVIEW WORK HAS BEEN DESIGNED TO CONSIDER THE AVAILABLE LITERATURE CONCERNING THE EFFECTIVENESS OF YOGA IN THE MANAGEMENT OF THE POLYCYSTIC OVARIAN SYNDROME. IT INCLUDES SOME RESEARCH PAPERS PUBLISHED BETWEEN 2012 AND 2019. BY PROVIDING YOGIC TREATMENT EFFECT ON SEVERAL PARAMETERS (SUCH AS BLOOD LIPID LEVEL, GLUCOSE METABOLISM, ENDOCRINE PARAMETERS, QUALITY OF LIFE, RESTING CARDIOVASCULAR PARAMETERS, LEVEL OF ANXIETY, DEPRESSION) ON THE WOMAN WITH POLYCYSTIC OVARIAN SYNDROME WERE MEASURED. AFTER THOROUGHLY STUDYING ABOUT 74 RESEARCH PAPERS, 16 ARE FOUND MOST RELEVANT TO BE REVIEWED. THE STUDIES OF THESE PAPERS CONCLUDED THE SUCCESSFUL USE OF DIFFERENT YOGIC LIMBS FOR THE MANAGEMENT OF POLYCYSTIC OVARIAN SYNDROME WITH OR WITHOUT MEDICATIONS.	2021	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
12 1569  33 MALE REPRODUCTIVE HEALTH AND YOGA. NOW-A-DAYS REPRODUCTIVE HEALTH PROBLEMS ALONG WITH INFERTILITY IN MALE IS VERY OFTEN OBSERVED. VARIOUS ASSISTED REPRODUCTIVE TECHNOLOGIES HAVE BEEN INTRODUCED TO SOLVE THE PROBLEM, BUT COMMON PEOPLE CANNOT AFFORD THE COST OF SUCH PROCEDURES. VARIOUS AYURVEDIC AND OTHER ALTERNATIVE MEDICINES, ALONG WITH REGULAR YOGA PRACTICE ARE PROVEN TO BE NOT ONLY EFFECTIVE TO ENHANCE THE REPRODUCTIVE HEALTH IN MEN TO PRODUCE A SUCCESSFUL PREGNANCY, BUT ALSO TO REGULATE SEXUAL DESIRE IN MEN WHO PRACTICE CELIBACY. YOGA IS REPORTED TO REDUCE STRESS AND ANXIETY, IMPROVE AUTONOMIC FUNCTIONS BY TRIGGERING NEUROHORMONAL MECHANISMS BY THE SUPPRESSION OF SYMPATHETIC ACTIVITY, AND EVEN, TODAY, SEVERAL REPORTS SUGGESTED REGULAR YOGA PRACTICE FROM CHILDHOOD IS BENEFICIAL FOR REPRODUCTIVE HEALTH. IN THIS REGARD THE PRESENT REVIEW IS AIMED TO PROVIDE ALL THE NECESSARY INFORMATION REGARDING THE EFFECTIVENESS OF YOGA PRACTICE TO HAVE A BETTER REPRODUCTIVE HEALTH AND TO PREVENT INFERTILITY.	2013	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
13 1789  38 PRELIMINARY INDICATIONS OF THE EFFECT OF A BRIEF YOGA INTERVENTION ON MARKERS OF INFLAMMATION AND DNA METHYLATION IN CHRONICALLY STRESSED WOMEN. YOGA IS ASSOCIATED WITH REDUCED STRESS AND INCREASED WELL-BEING, ALTHOUGH THE MOLECULAR BASIS FOR THESE BENEFITS IS NOT CLEAR. MOUNTING EVIDENCE IMPLICATES THE IMMUNE RESPONSE, WITH CURRENT STUDIES FOCUSED ON PROTEIN IMMUNE MARKERS (SUCH AS CYTOKINES) IN CLINICAL POPULATIONS. TO EXPLORE THE MOLECULAR IMPACT, THIS PILOT STUDY USES A SUBSAMPLE (N=28) FROM A RANDOMISED WAITLIST CONTROL TRIAL INVESTIGATING THE IMPACT OF AN 8-WEEK YOGA INTERVENTION IN A COMMUNITY POPULATION OF WOMEN REPORTING PSYCHOLOGICAL DISTRESS (N=116). WE MEASURED INTERLEUKIN-6 (IL-6), TUMOUR NECROSIS FACTOR (TNF) AND C-REACTIVE PROTEIN (CRP) PROTEIN LEVELS, AND THE DNA METHYLATION OF THESE GENES AND THE GLOBAL INDICATOR, LINE-1. CORRELATIONS BETWEEN THESE AND PSYCHOLOGICAL VARIABLES WERE EXPLORED, IDENTIFYING MODERATE CORRELATIONS WITH CRP PROTEIN LEVELS, AND METHYLATION OF IL-6, CRP AND LINE-1. MANY CYTOKINE SAMPLES WERE BELOW DETECTION, HOWEVER A MANN-WHITNEY U DEMONSTRATED A TREND OF MODERATE BETWEEN-GROUP EFFECT FOR ELEVATED IL-6 IN THE YOGA GROUP. METHYLATION ANALYSES APPLIED CROSS-SECTIONAL AND NON-CONTROLLED LONGITUDINAL ANALYSES. WAIST-TO-HEIGHT RATIO AND AGE WERE COVARIED. WE DEMONSTRATED REDUCED METHYLATION OF THE TNF REGION IN THE YOGA GROUP RELATIVE TO THE WAITLIST CONTROL GROUP. NO OTHER GENES DEMONSTRATED A SIGNIFICANT DIFFERENCE. LONGITUDINAL ANALYSIS FURTHER SUPPORTED THESE RESULTS. THIS STUDY IS ONE OF THE FIRST TO EXPLORE YOGA AND IMMUNOLOGICAL MARKERS IN A NON-CLINICAL POPULATION, AND IS THE FIRST STUDY TO EXPLORE DNA METHYLATION. THESE FINDINGS INDICATE THAT FURTHER RESEARCH INTO MOLECULAR IMPACT OF YOGA ON MARKERS OF IMMUNE FUNCTION IS WARRANTED, WITH LARGER STUDIES REQUIRED.	2016	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
14 1767  34 POTENTIAL BENEFITS OF YOGA IN PREGNANCY-RELATED COMPLICATIONS DURING THE COVID-19 PANDEMIC AND IMPLICATIONS FOR WORKING WOMEN. BACKGROUND: PREGNANCY IS A VULNERABLE PERIOD OF GROWTH AND ENRICHMENT ALONG WITH MANY PHYSIOLOGICAL AND PSYCHOLOGICAL CHALLENGES. THESE CHANGES CAN LEAD TO COMPLICATIONS IF COMPOUNDED BY EXTERNAL STRESS AND ANXIETY. COVID-19 HAS EMERGED AS A CHIEF STRESSOR AMONG THE GENERAL POPULATION AND IS A SERIOUS THREAT AMONG VULNERABLE POPULATIONS. THEREFORE, THERE IS A NEED FOR STRESS MANAGEMENT TOOLS, SUCH AS YOGA AND PHYSICAL EXERCISES, BOTH AT HOME AND AT WORK. THESE CAN BE ADOPTED DURING THE PANDEMIC WITH PROPER MAINTENANCE OF SOCIAL DISTANCING. OBJECTIVE: TO EVALUATE AND COMPILE LITERATURE THAT HAS REPORTED THE HEALTH OUTCOMES OF YOGA INTERVENTION ON PREGNANCY AT THE WORKPLACE AND ANALYZES BOTH THE RESTRICTIONS AS WELL AS ADVANTAGES OF ITS BENEFICIAL EFFECTS IN COMPARISON TO PHYSICAL EXERCISES. METHODOLOGY: A COMPREHENSIVE LITERATURE REVIEW WAS CONDUCTED UTILIZING PUBMED AND GOOGLE SCHOLAR. THE KEYWORDS USED FOR THE SEARCH INCLUDE "YOGA", "WORK", "COMPLICATIONS", "PHYSICAL EXERCISE", "DRUGS" AND "COVID" INDIFFERENT PERMUTATIONS AND COMBINATIONS WITH "PREGNANCY". WE COMPILED THE LITERATURE WITH RESPECT TO PREGNANCY COMPLICATIONS AND THE EFFECTS OF DRUGS, PHYSICAL ACTIVITY AND YOGA FOR PREVENTING THESE COMPLICATIONS. RESULTS: WE NOTED THAT PREGNANCY-RELATED COMPLICATIONS ARE BECOMING MORE PREVALENT BECAUSE OF A SEDENTARY LIFESTYLE, RESTRICTED PHYSICAL ACTIVITY AND GROWING STRESS. IN SUCH SITUATIONS, A HOME OR WORKPLACE YOGA PROTOCOL CAN COMBINE BOTH EXERCISE AND MINDFULNESS-BASED ALLEVIATION OF ANXIETY FOR BOTH WORKING AND NON-WORKING WOMEN. CONCLUSION: YOGA CAN BE EFFECTIVE FOR COMBATING STRESS AND ANXIETY BESIDES BOOSTING IMMUNITY IN PREGNANT WORKING WOMEN CONFRONTED WITH THE COVID-19 PANDEMIC.	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
15 1394  45 IMPACT OF YOGA BASED LIFESTYLE INTERVENTION ON PSYCHOLOGICAL STRESS AND QUALITY OF LIFE IN THE PARENTS OF CHILDREN WITH RETINOBLASTOMA. BACKGROUND: CHILDHOOD CANCERS ARE ASSOCIATED WITH A PSYCHOLOGICAL BURDEN TO THE PARENTS AND HENCE, DECLINE THEIR MENTAL AND PHYSICAL HEALTH AND OVERALL QUALITY OF LIFE. PURPOSE: THE PURPOSE OF THE PRESENT STUDY IS TO INVESTIGATE THE IMPACT OF 12-WEEKS YOGA BASED LIFESTYLE INTERVENTION ON PSYCHOLOGICAL STRESS AND QUALITY OF LIFE IN THE PARENTS OF CHILDREN AFFECTED WITH RETINOBLASTOMA. METHOD: SINGLE ARM PROSPECTIVE CLINICAL TRIAL CONDUCTED FROM OCTOBER 2015 TO OCTOBER 2017 AT THE LABORATORY FOR MOLECULAR REPRODUCTION AND GENETICS, DEPARTMENT OF ANATOMY, ALL INDIA INSTITUTE OF MEDICAL SCIENCES, NEW DELHI, INDIA. A PRE-TESTED 12-WEEKS YOGA BASED LIFESTYLE INTERVENTION INCLUDED ASANAS (PHYSICAL POSTURES), PRANAYAMA (BREATHING EXERCISES), DHYANA (MEDITATION), RELAXATION TECHNIQUES, LECTURES AND FILMS ON YOGA, INTERACTIVE SESSIONS AND INDIVIDUALIZED ADVICE WAS ADMINISTERED TO THE PARTICIPANTS. RESULTS: 12-WEEKS OF YOGA BASED LIFESTYLE INTERVENTION PROGRAMME LEADS TO A SIGNIFICANT IMPROVEMENT IN PSYCHOLOGICAL STRESS AND OVERALL QUALITY OF LIFE IN THE PARENTS OF RETINOBLASTOMA PATIENTS. THERE WAS A SIGNIFICANT IMPROVEMENT IN ALL THE DOMAINS (PHYSICAL HEALTH, PSYCHOLOGICAL HEALTH, SOCIAL RELATIONSHIPS, AND ENVIRONMENT) OF WHOQOL-BREF FROM BASELINE (DAY 0) TO 12-WEEKS OF YOGA BASED LIFESTYLE INTERVENTION. YOGA BASED LIFESTYLE INTERVENTION ALSO LED TO A SIGNIFICANT INCREASE IN THE LEVELS OF BRAIN DERIVED NEUROTROPHIC FACTOR, DEHYDROEPIANDROSTERONE SULPHATE, SIRTUIN 1 AND DECREASED THE CORTISOL AND IL-6 LEVELS. CONCLUSION: YOGA BASED LIFESTYLE INTERVENTION REDUCED THE SEVERITY OF PSYCHOLOGICAL STRESS AND RESULTED IN IMPROVEMENT IN OVERALL QUALITY OF LIFE AND UPREGULATION IN LEVELS OF SYSTEMIC BIOMARKERS OF NEUROPLASTICITY. YBLI MAY SERVE AS A BENEFICIAL THERAPY AND MAY ALSO ACT AS AN EFFECTIVE MEDIUM FOR BETTER STRESS MANAGEMENT TO DEVELOP BETTER COPING STRATEGIES IN THE PARENTS OF RETINOBLASTOMA PATIENTS.	2019	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
16 2038  58 TELOMERASE ACTIVITY AND CELLULAR AGING MIGHT BE POSITIVELY MODIFIED BY A YOGA-BASED LIFESTYLE INTERVENTION. OBJECTIVES: RECENT STUDIES SHOWED THAT A BRIEF YOGA-BASED LIFESTYLE INTERVENTION WAS EFFICACIOUS IN REDUCING LEVELS OF OXIDATIVE STRESS AND CELLULAR AGING IN OBESE MEN. THE OBJECTIVE OF THIS CASE REPORT WAS TO ASSESS THE EFFICACY OF THIS INTERVENTION IN REDUCING THE LEVELS OF BIOCHEMICAL MARKERS OF CELLULAR AGEING, OXIDATIVE STRESS, AND INFLAMMATION AT BASELINE (DAY 0), AT THE END OF ACTIVE INTERVENTION (DAY 10), AND FOLLOW-UP AT DAY 90. DESIGN: SINGLE CASE REPORT FROM A PROSPECTIVE ONGOING STUDY WITH PRE-POST DESIGN ASSESSING THE LEVEL OF VARIOUS MARKERS OF CELLULAR AGING. SETTING: INTEGRAL HEALTH CLINIC, AN OUTPATIENT FACILITY CONDUCTING MEDITATION AND YOGA-BASED LIFESTYLE INTERVENTION PROGRAMS FOR MANAGEMENT OF CHRONIC DISEASES. PATIENT: A 31-YEAR-OLD MAN WITH CLASS I OBESITY (BODY-MASS INDEX, 29.5 KG/M(2)) WHO PRESENTED TO THE MEDICINE OUTPATIENT DEPARTMENT AT ALL INDIA INSTITUTE OF MEDICAL SCIENCES, NEW DELHI, INDIA, WITH A HISTORY OF FATIGUE, DIFFICULTY LOSING WEIGHT, AND LACK OF MOTIVATION. HE NOTED A MARKED DECREASE IN HIS ENERGY LEVEL, PARTICULARLY IN THE AFTERNOON. INTERVENTION: A PRETESTED INTERVENTION PROGRAM INCLUDED ASANAS (POSTURES), PRANAYAMA (BREATHING EXERCISES), STRESS MANAGEMENT, GROUP DISCUSSIONS, LECTURES, AND INDIVIDUALIZED ADVICE. RESULTS: FROM BASELINE (DAY 0) TO DAY 90, THE ACTIVITY OF TELOMERASE AND LEVELS OF BETA-ENDORPHINS, PLASMA CORTISOL, AND INTERLEUKIN-6 INCREASED, AND A SUSTAINED REDUCTION IN OXIDATIVE STRESS MARKERS, SUCH AS REACTIVE OXYGEN SPECIES AND 8-HYDROXY-2-DEOXY-GUANOSINE LEVELS. CONCLUSIONS: ADOPTING YOGA/MEDITATION-BASED LIFESTYLE MODIFICATION CAUSES REVERSAL OF MARKERS OF AGING, MAINLY OXIDATIVE STRESS, TELOMERASE ACTIVITY, AND OXIDATIVE DNA DAMAGE. THIS MAY NOT ONLY DELAY AGING AND PROLONG A YOUTHFUL HEALTHY LIFE BUT ALSO DELAY OR PREVENT ONSET OF SEVERAL LIFESTYLE-RELATED DISEASES, OF WHICH OXIDATIVE STRESS AND INFLAMMATION ARE THE CHIEF CAUSE. THIS REPORT SUGGESTS THIS SIMPLE LIFESTYLE INTERVENTION MAY BE THERAPEUTIC FOR OXIDATIVE DNA DAMAGE AND OXIDATIVE STRESS.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
17 2884  17 YOGA: AN ADJUNCT TO INFERTILITY TREATMENT. YOGA AND MEDITATION CAN HELP WOMEN EXPERIENCING THE CHALLENGES OF INFERTILITY. THE PRACTICE OF MEDITATION AND RELAXATION CAN HELP INCREASE THE CLARITY OF THE MIND, MAINTAIN HEALTHY BODY CHEMISTRY, AND GIVE PATIENTS THE PATIENCE TO UNDERGO THE RIGORS OF INFERTILITY TREATMENTS. WHEN ONE UNDERSTANDS AND CAN ATTAIN PHYSICAL RELAXATION, ONE TENDS TO FEEL BETTER ABOUT THE BODY ITSELF, AND BEGINS TO TREAT THE BODY WITH MORE RESPECT. THIS UNDERSTANDING CAN LEAD TO HEALTHIER LIFESTYLE HABITS AS WELL AS INCREASED SENSITIVITY REGARDING SYMPTOMS AND BODY PROCESSES. THIS IS BENEFICIAL TO BOTH DOCTOR AND PATIENT AS THE PATIENT CAN REPORT WITH MORE CLARITY AND SENSE CYCLES AND PHYSICAL ISSUES MORE READILY.	2003	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
18 1639  38 MODULATION OF IMMUNE RESPONSES IN STRESS BY YOGA. STRESS IS A CONSTANT FACTOR IN TODAY'S FASTPACED LIFE THAT CAN JEOPARDIZE OUR HEALTH IF LEFT UNCHECKED. IT IS ONLY IN THE LAST HALF CENTURY THAT THE ROLE OF STRESS IN EVERY AILMENT FROM THE COMMON COLD TO AIDS HAS BEEN EMPHASIZED, AND THE MECHANISMS INVOLVED IN THIS PROCESS HAVE BEEN STUDIED. STRESS INFLUENCES THE IMMUNE RESPONSE PRESUMABLY THROUGH THE ACTIVATION OF THE HYPOTHALAMIC-PITUITARY ADRENAL AXIS, HYPOTHALAMIC PITUITARY-GONADAL AXIS, AND THE SYMPATHETIC-ADRENAL-MEDULLARY SYSTEM. VARIOUS NEUROTRANSMITTERS, NEUROPEPTIDES, HORMONES, AND CYTOKINES MEDIATE THESE COMPLEX BIDIRECTIONAL INTERACTIONS BETWEEN THE CENTRAL NERVOUS SYSTEM (CNS) AND THE IMMUNE SYSTEM. THE EFFECTS OF STRESS ON THE IMMUNE RESPONSES RESULT IN ALTERATIONS IN THE NUMBER OF IMMUNE CELLS AND CYTOKINE DYSREGULATION. VARIOUS STRESS MANAGEMENT STRATEGIES SUCH AS MEDITATION, YOGA, HYPNOSIS, AND MUSCLE RELAXATION HAVE BEEN SHOWN TO REDUCE THE PSYCHOLOGICAL AND PHYSIOLOGICAL EFFECTS OF STRESS IN CANCERS AND HIV INFECTION. THIS REVIEW AIMS TO DISCUSS THE EFFECT OF STRESS ON THE IMMUNE SYSTEM AND EXAMINE HOW RELAXATION TECHNIQUES SUCH AS YOGA AND MEDITATION COULD REGULATE THE CYTOKINE LEVELS AND HENCE, THE IMMUNE RESPONSES DURING STRESS.	2008	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
19 2530  30 YOGA EFFECTS ON ANTHROPOMETRIC INDICES AND POLYCYSTIC OVARY SYNDROME SYMPTOMS IN WOMEN UNDERGOING INFERTILITY TREATMENT: A RANDOMIZED CONTROLLED CLINICAL TRIAL. THE AIM OF THIS STUDY WAS TO INVESTIGATE THE EFFECTS OF YOGA EXERCISES ON ANTHROPOMETRIC PARAMETER AND CLINICAL SIGN OF PCOS AMONG WOMEN UNDERGOING INFERTILITY TREATMENT. THIS CLINICAL TRIAL STUDY WAS PERFORMED ON 61 WOMEN WITH PCOS WHO HAVE UNDERGONE INFERTILITY TREATMENT AT SAREM HOSPITAL IN TEHRAN, IRAN. THE PATIENTS WERE FIRST SELECTING BASED ON PURPOSEFUL AND THEN RANDOMLY ASSIGNING TO THE INTERVENTION AND CONTROL GROUPS. IN THE INTERVENTION GROUP, YOGA EXERCISES WERE PERFORMED FOR 6 WEEKS AND THE PATIENTS IN THE CONTROL GROUP ONLY RECEIVED ROUTINE CARE. ANTHROPOMETRIC PARAMETERS AND CLINICAL SIGNS WERE PERFORMED AND RECORDED. AFTER THE INTERVENTION, HERE WAS A SIGNIFICANT REDUCTION IN HIRSUTISM, ABDOMINAL CIRCUMFERENCE, AND HIP CIRCUMFERENCE SCORES IN THE INTERVENTION GROUP COMPARED TO THE CONTROL GROUP (P < 0.05). GIVEN THE EFFECTS OF YOGA EXERCISES ON THE IMPROVEMENT OF HIRSUTISM, ABDOMINAL CIRCUMFERENCE, AND HIP CIRCUMFERENCE, IT IS SUGGESTED TO USE YOGA AS A TREATMENT STRATEGY IN WOMEN WITH PCOS.	2021	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
20 1142  33 EFFICACY, FEASIBILITY, AND ACCEPTABILITY OF PERINATAL YOGA ON WOMEN'S MENTAL HEALTH AND WELL-BEING: A SYSTEMATIC LITERATURE REVIEW. INTRODUCTION: PERINATAL MAJOR DEPRESSIVE DISORDER AFFECTS 20% OF WOMEN, WHILE PERINATAL ANXIETY AFFECTS 10% OF WOMEN. ALTHOUGH PHARMACOLOGICAL TREATMENT HAS SHOWN EFFECTIVENESS, MANY PREGNANT WOMEN ARE CONCERNED ABOUT POTENTIAL ADVERSE EFFECTS ON THE FETUS, MATERNAL-INFANT BONDING, AND CHILD DEVELOPMENT. APPROXIMATELY 38% OF AMERICAN ADULTS USE COMPLEMENTARY AND ALTERNATIVE MEDICINE, INCLUDING YOGA AND OTHER MIND-BODY STRATEGIES. ALTHOUGH COMPLEMENTARY AND ALTERNATIVE MEDICINE HAS BEEN LESS STUDIED IN THE PERINATAL POPULATION, IT POTENTIALLY OFFERS WOMEN AND THEIR PROVIDERS ALTERNATIVES TO TRADITIONAL MEDICATION FOR TREATMENT OF PERINATAL DEPRESSION AND ANXIETY. THUS, THE PURPOSE OF THIS SYSTEMATIC REVIEW WAS TO EXAMINE EXISTING EMPIRICAL LITERATURE ON YOGA AND ITS EFFECTS ON WOMEN'S HEALTH AND WELL-BEING DURING THE PERINATAL PERIOD. METHOD: FOLLOWING PRISMA (PREFERRED REPORTING ITEMS FOR SYSTEMATIC REVIEWS AND META-ANALYSES) GUIDELINES FOR SYSTEMIC LITERATURE REVIEWS, LITERATURE SEARCHES USING RELEVANT SEARCH TERMS WERE PERFORMED IN FOUR MAJOR ELECTRONIC DATABASES: CINAHL, PUBMED, PSYCINFO, AND EMBASE. THIRTEEN PUBLICATIONS MET INCLUSION CRITERIA. RESULTS: RESULTS INDICATED THAT YOGA INTERVENTIONS ARE GENERALLY EFFECTIVE IN REDUCING ANXIETY AND DEPRESSION IN PREGNANT WOMEN. DISCUSSION: THE USE OF YOGA IN THE PERINATAL PERIOD SHOWS PROMISE IN IMPROVING MENTAL HEALTH AND WELL-BEING FOR WOMEN AND INFANTS. THIS REVIEW CAN INFORM FUTURE YOGA INTERVENTION STUDIES AND CLINICAL PRACTICE WITH THE PERINATAL POPULATION.	2016