1 2245 155 THE INFLUENCE OF YOGA-BASED PROGRAMS ON RISK PROFILES IN ADULTS WITH TYPE 2 DIABETES MELLITUS: A SYSTEMATIC REVIEW. THERE IS GROWING EVIDENCE THAT YOGA MAY OFFER A SAFE AND COST-EFFECTIVE INTERVENTION FOR TYPE 2 DIABETES MELLITUS (DM 2). HOWEVER, SYSTEMATIC REVIEWS ARE LACKING. THIS ARTICLE CRITICALLY REVIEWS THE PUBLISHED LITERATURE REGARDING THE EFFECTS OF YOGA-BASED PROGRAMS ON PHYSIOLOGIC AND ANTHROPOMETRIC RISK PROFILES AND RELATED CLINICAL OUTCOMES IN ADULTS WITH DM 2. WE PERFORMED A COMPREHENSIVE LITERATURE SEARCH USING FOUR COMPUTERIZED ENGLISH AND INDIAN SCIENTIFIC DATABASES. THE SEARCH WAS RESTRICTED TO ORIGINAL STUDIES (1970-2006) THAT EVALUATED THE METABOLIC AND CLINICAL EFFECTS OF YOGA IN ADULTS WITH DM 2. STUDIES TARGETING CLINICAL POPULATIONS WITH CARDIOVASCULAR DISORDERS THAT INCLUDED ADULTS WITH COMORBID DM WERE ALSO EVALUATED. DATA WERE EXTRACTED REGARDING STUDY DESIGN, SETTING, TARGET POPULATION, INTERVENTION, COMPARISON GROUP OR CONDITION, OUTCOME ASSESSMENT, DATA ANALYSIS AND PRESENTATION, FOLLOW-UP, AND KEY RESULTS, AND THE QUALITY OF EACH STUDY WAS EVALUATED ACCORDING TO SPECIFIC PREDETERMINED CRITERIA. WE IDENTIFIED 25 ELIGIBLE STUDIES, INCLUDING 15 UNCONTROLLED TRIALS, 6 NON-RANDOMIZED CONTROLLED TRIALS AND 4 RANDOMIZED CONTROLLED TRIALS (RCTS). OVERALL, THESE STUDIES SUGGEST BENEFICIAL CHANGES IN SEVERAL RISK INDICES, INCLUDING GLUCOSE TOLERANCE AND INSULIN SENSITIVITY, LIPID PROFILES, ANTHROPOMETRIC CHARACTERISTICS, BLOOD PRESSURE, OXIDATIVE STRESS, COAGULATION PROFILES, SYMPATHETIC ACTIVATION AND PULMONARY FUNCTION, AS WELL AS IMPROVEMENT IN SPECIFIC CLINICAL OUTCOMES. YOGA MAY IMPROVE RISK PROFILES IN ADULTS WITH DM 2, AND MAY HAVE PROMISE FOR THE PREVENTION AND MANAGEMENT OF CARDIOVASCULAR COMPLICATIONS IN THIS POPULATION. HOWEVER, THE LIMITATIONS CHARACTERIZING MOST STUDIES PRECLUDE DRAWING FIRM CONCLUSIONS. ADDITIONAL HIGH-QUALITY RCTS ARE NEEDED TO CONFIRM AND FURTHER ELUCIDATE THE EFFECTS OF STANDARDIZED YOGA PROGRAMS IN POPULATIONS WITH DM 2.	2007	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
2 1910 117 RISK INDICES ASSOCIATED WITH THE INSULIN RESISTANCE SYNDROME, CARDIOVASCULAR DISEASE, AND POSSIBLE PROTECTION WITH YOGA: A SYSTEMATIC REVIEW. OBJECTIVE: TO CONDUCT A SYSTEMATIC REVIEW OF PUBLISHED LITERATURE REGARDING THE EFFECTS OF YOGA, A PROMISING MIND-BODY THERAPY, ON SPECIFIC ANTHROPOMETRIC AND PHYSIOLOGIC INDICES OF CARDIOVASCULAR DISEASE (CVD) RISK AND ON RELATED CLINICAL ENDPOINTS. METHODS: WE PERFORMED A LITERATURE SEARCH USING 4 COMPUTERIZED ENGLISH AND INDIAN SCIENTIFIC DATABASES. THE SEARCH WAS RESTRICTED TO ORIGINAL STUDIES (1970 TO 2004) EVALUATING THE EFFECTS OF YOGA ON CVD OR INDICES OF CVD RISK ASSOCIATED WITH THE INSULIN RESISTANCE SYNDROME (IRS). RANDOMIZED CONTROLLED TRIALS (RCTS), NONRANDOMIZED CONTROLLED TRIALS, UNCONTROLLED (PRE AND POST) CLINICAL TRIALS, AND CROSS-SECTIONAL (OBSERVATIONAL) STUDIES WERE INCLUDED IF THEY MET SPECIFIC CRITERIA. DATA WERE EXTRACTED REGARDING STUDY DESIGN, SETTING, POPULATION SIZE AND CHARACTERISTICS, INTERVENTION TYPE AND DURATION, COMPARISON GROUP OR CONDITION, OUTCOME ASSESSMENT, DATA ANALYSIS AND PRESENTATION, FOLLOW-UP, AND KEY RESULTS, AND THE QUALITY OF EACH STUDY WAS EVALUATED ACCORDING TO SPECIFIC PREDETERMINED CRITERIA. RESULTS: WE IDENTIFIED 70 ELIGIBLE STUDIES, INCLUDING 1 OBSERVATIONAL STUDY, 26 UNCONTROLLED CLINICAL TRIALS, 21 NONRANDOMIZED CONTROLLED CLINICAL TRIALS, AND 22 RCTS. TOGETHER, THE REPORTED RESULTS OF THESE STUDIES INDICATE BENEFICIAL CHANGES OVERALL IN SEVERAL IRS-RELATED INDICES OF CVD RISK, INCLUDING GLUCOSE TOLERANCE AND INSULIN SENSITIVITY, LIPID PROFILES, ANTHROPOMETRIC CHARACTERISTICS, BLOOD PRESSURE, OXIDATIVE STRESS, COAGULATION PROFILES, SYMPATHETIC ACTIVATION, AND CARDIOVAGAL FUNCTION, AS WELL AS IMPROVEMENT IN SEVERAL CLINICAL ENDPOINTS. CONCLUSIONS: COLLECTIVELY, THESE STUDIES SUGGEST THAT YOGA MAY REDUCE MANY IRS-RELATED RISK FACTORS FOR CVD, MAY IMPROVE CLINICAL OUTCOMES, AND MAY AID IN THE MANAGEMENT OF CVD AND OTHER IRS-RELATED CONDITIONS. HOWEVER, THE METHODOLOGIC AND OTHER LIMITATIONS CHARACTERIZING MOST OF THESE STUDIES PRECLUDE DRAWING FIRM CONCLUSIONS. ADDITIONAL HIGH QUALITY RCTS ARE NEEDED TO CONFIRM AND FURTHER ELUCIDATE THE EFFECTS OF STANDARDIZED YOGA PROGRAMS ON SPECIFIC INDICES OF CVD RISK AND RELATED CLINICAL ENDPOINTS.	2005	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
3 1555  30 LONG-TERM ASHTANGA YOGA PRACTICE DECREASES MEDIAL TEMPORAL AND BRAINSTEM GLUCOSE METABOLISM IN RELATION TO YEARS OF EXPERIENCE. BACKGROUND: YOGA IS INCREASINGLY POPULAR WORLDWIDE WITH SEVERAL PHYSICAL AND MENTAL BENEFITS, BUT THE UNDERLYING NEUROBIOLOGY REMAINS UNCLEAR. WHEREAS MANY STUDIES HAVE FOCUSED ON PURE MEDITATIONAL ASPECTS, THE TRIAD OF YOGA INCLUDES MEDITATION, POSTURES, AND BREATHING. WE CONDUCTED A CROSS-SECTIONAL STUDY COMPARING EXPERIENCED YOGA PRACTITIONERS TO YOGA-NAIVE HEALTHY SUBJECTS USING A MULTIPARAMETRIC 2 X 2 DESIGN WITH SIMULTANEOUS POSITRON EMISSION TOMOGRAPHY/MAGNETIC RESONANCE (PET/MR) IMAGING. METHODS: (18)F-FDG PET, MORPHOMETRIC AND DIFFUSION TENSOR IMAGING, RESTING STATE FMRI, AND MR SPECTROSCOPY WERE ACQUIRED IN 10 EXPERIENCED (4.8 +/- 2.3 YEARS OF REGULAR YOGA EXPERIENCE) YOGA PRACTITIONERS AND 15 MATCHED CONTROLS IN REST AND AFTER A SINGLE PRACTICE (YOGA PRACTICE AND PHYSICAL EXERCISE, RESPECTIVELY). RESULTS: IN REST, DECREASED REGIONAL GLUCOSE METABOLISM IN THE MEDIAL TEMPORAL CORTEX, STRIATUM, AND BRAINSTEM WAS OBSERVED IN YOGA PRACTITIONERS COMPARED TO CONTROLS (P < 0.0001), WITH A SIGNIFICANT INVERSE CORRELATION OF RESTING PARAHIPPOCAMPAL AND BRAINSTEM METABOLISM WITH YEARS OF REGULAR YOGA PRACTICE (RHO < - 0.63, P < 0.05). A SINGLE YOGA PRACTICE RESULTED IN SIGNIFICANT HYPERMETABOLISM IN THE CEREBELLUM (P < 0.0001). NONE OF THE MR MEASURES DIFFERED, BOTH AT REST AND AFTER INTERVENTION. CONCLUSIONS: EXPERIENCED YOGA PRACTITIONERS SHOW REGIONAL LONG-TERM DECREASES IN GLUCOSE METABOLISM RELATED TO YEARS OF PRACTICE. TO ELUCIDATE A POTENTIAL CAUSALITY, A PROSPECTIVE LONGITUDINAL STUDY IN YOGA-NAIVE INDIVIDUALS IS WARRANTED.	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
4 2834  44 YOGA'S EFFECT ON INFLAMMATORY BIOMARKERS AND METABOLIC RISK FACTORS IN A HIGH RISK POPULATION - A CONTROLLED TRIAL IN PRIMARY CARE. BACKGROUND: YOGA CAN REDUCE BLOOD PRESSURE AND HAS ALSO BEEN SUGGESTED TO REDUCE INFLAMMATORY BIOMARKERS AND METABOLIC RISK FACTORS FOR CARDIOVASCULAR DISEASES (CVDS). WE AIMED TO ASSESS THE BENEFIT OF TWO YOGA INTERVENTIONS ON INFLAMMATORY BIOMARKERS AND METABOLIC RISK FACTORS IN A HIGH RISK POPULATION IN PRIMARY CARE. METHODS: ADULT PATIENTS FROM A HEALTH CARE CENTER IN SWEDEN, WITH DIAGNOSED HYPERTENSION, WERE INVITED TO UNDERGO A BASELINE CHECK AT THE HEALTH CARE CENTER. BASELINE CHECK INCLUDED STANDARDIZED BLOOD PRESSURE MEASUREMENT, BMI AND WEIGHT CIRCUMFERENCE MEASUREMENTS, BLOOD SAMPLING (HS-CRP, IL-6, FP-GLUCOSE, HBA1C, CHOLESTEROL, TG, LDL AND HDL) AND A QUESTIONNAIRE ON SELF-RATED QUALITY OF LIFE (WHOQOL-BREF). THERE WERE THREE GROUPS: 1) YOGA CLASS WITH YOGA INSTRUCTOR; 2) YOGA AT HOME; AND 3) A CONTROL GROUP. IN TOTAL, 83 PATIENTS WERE INCLUDED AND MATCHED AT THE GROUP LEVEL FOR SYSTOLIC BLOOD PRESSURE. A MAJORITY OF THE PATIENTS (92 %) WERE ON ANTIHYPERTENSIVE MEDICATION, WHICH THEY WERE REQUESTED NOT TO CHANGE DURING THE STUDY. AFTER 12 WEEKS OF INTERVENTION, THE ASSESSMENTS WERE PERFORMED AGAIN. RESULTS: WE RECORDED NO EVIDENCE THAT YOGA ALTERED INFLAMMATORY BIOMARKERS OR METABOLIC RISK FACTORS IN OUR STUDY POPULATION. A TOTAL OF 49 PARTICIPANTS (59 %) MET THE CRITERIA FOR METABOLIC SYNDROME. CONCLUSION: THE YOGA INTERVENTIONS PERFORMED IN OUR STUDY DID NOT AFFECT INFLAMMATORY BIOMARKERS OR METABOLIC RISK FACTORS ASSOCIATED WITH CVD IN THE STUDY POPULATION OF PRIMARY CARE PATIENTS WITH HYPERTENSION. FURTHER RANDOMIZED TRIALS ARE NEEDED TO ELUCIDATE THE EFFECTS OF YOGA ON CVD RISK FACTORS IN THIS PARTICULAR GROUP. TRAIL REGISTRATION: NCT01302535 , FEBRUARY 22, 2011.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
5  668  43 EFFECT OF A 16-WEEK BIKRAM YOGA PROGRAM ON HEART RATE VARIABILITY AND ASSOCIATED CARDIOVASCULAR DISEASE RISK FACTORS IN STRESSED AND SEDENTARY ADULTS: A RANDOMIZED CONTROLLED TRIAL. BACKGROUND: CHRONIC ACTIVATION OF THE STRESS-RESPONSE CAN CONTRIBUTE TO CARDIOVASCULAR DISEASE RISK, PARTICULARLY IN SEDENTARY INDIVIDUALS. THIS STUDY INVESTIGATED THE EFFECT OF A BIKRAM YOGA INTERVENTION ON THE HIGH FREQUENCY POWER COMPONENT OF HEART RATE VARIABILITY (HRV) AND ASSOCIATED CARDIOVASCULAR DISEASE (CVD) RISK FACTORS (I.E. ADDITIONAL DOMAINS OF HRV, HEMODYNAMIC, HEMATOLOGIC, ANTHROPOMETRIC AND BODY COMPOSITION OUTCOME MEASURES) IN STRESSED AND SEDENTARY ADULTS. METHODS: ELIGIBLE ADULTS WERE RANDOMIZED TO AN EXPERIMENTAL GROUP (N = 29) OR A NO TREATMENT CONTROL GROUP (N = 34). EXPERIMENTAL GROUP PARTICIPANTS WERE INSTRUCTED TO ATTEND THREE TO FIVE SUPERVISED BIKRAM YOGA CLASSES PER WEEK FOR 16 WEEKS AT LOCAL STUDIOS. OUTCOME MEASURES WERE ASSESSED AT BASELINE (WEEK 0) AND COMPLETION (WEEK 17). RESULTS: SIXTY-THREE ADULTS (37.2 +/- 10.8 YEARS, 79% WOMEN) WERE INCLUDED IN THE INTENTION-TO-TREAT ANALYSIS. THE EXPERIMENTAL GROUP ATTENDED 27 +/- 18 CLASSES. ANALYSES OF COVARIANCE REVEALED NO SIGNIFICANT CHANGE IN THE HIGH-FREQUENCY COMPONENT OF HRV (P = 0.912, PARTIAL ETA (2) = 0.000) OR IN ANY SECONDARY OUTCOME MEASURE BETWEEN GROUPS OVER TIME. HOWEVER, REGRESSION ANALYSES REVEALED THAT HIGHER ATTENDANCE IN THE EXPERIMENTAL GROUP WAS ASSOCIATED WITH SIGNIFICANT REDUCTIONS IN DIASTOLIC BLOOD PRESSURE (P = 0.039; PARTIAL ETA (2) = 0.154), BODY FAT PERCENTAGE (P = 0.001, PARTIAL ETA (2) = 0.379), FAT MASS (P = 0.003, PARTIAL ETA (2) = 0.294) AND BODY MASS INDEX (P = 0.05, PARTIAL ETA (2) = 0.139). CONCLUSIONS: A 16-WEEK BIKRAM YOGA PROGRAM DID NOT INCREASE THE HIGH FREQUENCY POWER COMPONENT OF HRV OR ANY OTHER CVD RISK FACTORS INVESTIGATED. AS REVEALED BY POST HOC ANALYSES, LOW ADHERENCE LIKELY CONTRIBUTED TO THE NULL EFFECTS. FUTURE STUDIES ARE REQUIRED TO ADDRESS BARRIERS TO ADHERENCE TO BETTER ELUCIDATE THE DOSE-RESPONSE EFFECTS OF BIKRAM YOGA PRACTICE AS A MEDIUM TO LOWER STRESS-RELATED CVD RISK. TRIAL REGISTRATION: RETROSPECTIVELY REGISTERED WITH AUSTRALIA NEW ZEALAND CLINICAL TRIALS REGISTRY ACTRN12616000867493 . REGISTERED 04 JULY 2016.	2017	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
6 2629  63 YOGA FOR THE PRIMARY PREVENTION OF CARDIOVASCULAR DISEASE. BACKGROUND: A SEDENTARY LIFESTYLE AND STRESS ARE MAJOR RISK FACTORS FOR CARDIOVASCULAR DISEASE (CVD). SINCE YOGA INVOLVES EXERCISE AND IS THOUGHT TO HELP IN STRESS REDUCTION IT MAY BE AN EFFECTIVE STRATEGY IN THE PRIMARY PREVENTION OF CVD. OBJECTIVES: TO DETERMINE THE EFFECT OF ANY TYPE OF YOGA ON THE PRIMARY PREVENTION OF CVD. SEARCH METHODS: WE SEARCHED THE FOLLOWING ELECTRONIC DATABASES: THE COCHRANE CENTRAL REGISTER OF CONTROLLED TRIALS (CENTRAL) (2013, ISSUE 11) IN THE COCHRANE LIBRARY; MEDLINE (OVID) (1946 TO NOVEMBER WEEK 3 2013); EMBASE CLASSIC + EMBASE (OVID) (1947 TO 2013 WEEK 48); WEB OF SCIENCE (THOMSON REUTERS) (1970 TO 4 DECEMBER 2013); DATABASE OF ABSTRACTS OF REVIEWS OF EFFECTS (DARE), HEALTH TECHNOLOGY ASSESSMENT DATABASE AND HEALTH ECONOMICS EVALUATIONS DATABASE (ISSUE 4 OF 4, 2013) IN THE COCHRANE LIBRARY. WE ALSO SEARCHED A NUMBER OF ASIAN DATABASES AND THE ALLIED AND COMPLEMENTARY MEDICINE DATABASE (AMED) (INCEPTION TO DECEMBER 2012). WE SEARCHED TRIAL REGISTERS AND REFERENCE LISTS OF REVIEWS AND ARTICLES, AND APPROACHED EXPERTS IN THE FIELD. WE APPLIED NO LANGUAGE RESTRICTIONS. SELECTION CRITERIA: RANDOMISED CONTROLLED TRIALS LASTING AT LEAST THREE MONTHS INVOLVING HEALTHY ADULTS OR THOSE AT HIGH RISK OF CVD. TRIALS EXAMINED ANY TYPE OF YOGA AND THE COMPARISON GROUP WAS NO INTERVENTION OR MINIMAL INTERVENTION. OUTCOMES OF INTEREST WERE CLINICAL CVD EVENTS AND MAJOR CVD RISK FACTORS. WE DID NOT INCLUDE ANY TRIALS THAT INVOLVED MULTIFACTORIAL LIFESTYLE INTERVENTIONS OR WEIGHT LOSS. DATA COLLECTION AND ANALYSIS: TWO AUTHORS INDEPENDENTLY SELECTED TRIALS FOR INCLUSION, EXTRACTED DATA AND ASSESSED THE RISK OF BIAS. MAIN RESULTS: WE IDENTIFIED 11 TRIALS (800 PARTICIPANTS) AND TWO ONGOING STUDIES. STYLE AND DURATION OF YOGA DIFFERED BETWEEN TRIALS. HALF OF THE PARTICIPANTS RECRUITED TO THE STUDIES WERE AT HIGH RISK OF CVD. MOST OF STUDIES WERE AT RISK OF PERFORMANCE BIAS, WITH INADEQUATE DETAILS REPORTED IN MANY OF THEM TO JUDGE THE RISK OF SELECTION BIAS.NO STUDY REPORTED CARDIOVASCULAR MORTALITY, ALL-CAUSE MORTALITY OR NON-FATAL EVENTS, AND MOST STUDIES WERE SMALL AND SHORT-TERM. THERE WAS SUBSTANTIAL HETEROGENEITY BETWEEN STUDIES MAKING IT IMPOSSIBLE TO COMBINE STUDIES STATISTICALLY FOR SYSTOLIC BLOOD PRESSURE AND TOTAL CHOLESTEROL. YOGA WAS FOUND TO PRODUCE REDUCTIONS IN DIASTOLIC BLOOD PRESSURE (MEAN DIFFERENCE (MD) -2.90 MMHG, 95% CONFIDENCE INTERVAL (CI) -4.52 TO -1.28), WHICH WAS STABLE ON SENSITIVITY ANALYSIS, TRIGLYCERIDES (MD -0.27 MMOL/L, 95% CI -0.44 TO -0.11) AND HIGH-DENSITY LIPOPROTEIN (HDL) CHOLESTEROL (MD 0.08 MMOL/L, 95% CI 0.02 TO 0.14). HOWEVER, THE CONTRIBUTING STUDIES WERE SMALL, SHORT-TERM AND AT UNCLEAR OR HIGH RISK OF BIAS. THERE WAS NO CLEAR EVIDENCE OF A DIFFERENCE BETWEEN GROUPS FOR LOW-DENSITY LIPOPROTEIN (LDL) CHOLESTEROL (MD -0.09 MMOL/L, 95% CI -0.48 TO 0.30), ALTHOUGH THERE WAS MODERATE STATISTICAL HETEROGENEITY. ADVERSE EVENTS, OCCURRENCE OF TYPE 2 DIABETES AND COSTS WERE NOT REPORTED IN ANY OF THE INCLUDED STUDIES. QUALITY OF LIFE WAS MEASURED IN THREE TRIALS BUT THE RESULTS WERE INCONCLUSIVE. AUTHORS' CONCLUSIONS: THE LIMITED EVIDENCE COMES FROM SMALL, SHORT-TERM, LOW-QUALITY STUDIES. THERE IS SOME EVIDENCE THAT YOGA HAS FAVOURABLE EFFECTS ON DIASTOLIC BLOOD PRESSURE, HDL CHOLESTEROL AND TRIGLYCERIDES, AND UNCERTAIN EFFECTS ON LDL CHOLESTEROL. THESE RESULTS SHOULD BE CONSIDERED AS EXPLORATORY AND INTERPRETED WITH CAUTION.	2014	

7 2194  43 THE EFFECTS OF YOGA VERSUS STRETCHING AND RESISTANCE TRAINING EXERCISES ON PSYCHOLOGICAL DISTRESS FOR PEOPLE WITH MILD-TO-MODERATE PARKINSON'S DISEASE: STUDY PRXOTOCOL FOR A RANDOMIZED CONTROLLED TRIAL. BACKGROUND: PSYCHOLOGICAL DISTRESS IS PREVALENT AMONG PEOPLE WITH PARKINSON'S DISEASE (PD) AND AGGRAVATES THEIR MOTOR SYMPTOMS, THEREBY LEADING TO INCREASED DISABILITY, HIGH HEALTHCARE COSTS, AND POOR HEALTH-RELATED QUALITY OF LIFE (HRQOL). THE UNDER-RECOGNITION AND ADVERSE EFFECTS OF THE PHARMACOLOGICAL MANAGEMENT OF ANXIETY AND DEPRESSION AMONG THE PD POPULATION ARE CONSIDERABLE. THUS, ADOPTING A COMPLEMENTARY AND ALTERNATIVE MANAGEMENT (CAM) APPROACH TO ADDRESS THIS PROBLEM IS IMPORTANT. YOGA, ONE OF THE MOST COMMON "MIND-BODY" CAM THERAPIES, CAN IMPROVE THE PSYCHOLOGICAL WELLBEING OF PEOPLE WITH CHRONIC ILLNESSES. HOWEVER, LIMITED RESEARCH ON THE EFFECTS OF YOGA IN PEOPLE WITH PD HAS BEEN CONDUCTED. THIS STUDY WILL DETERMINE THE EFFECTS OF YOGA ON THE PSYCHOLOGICAL WELLBEING OF PEOPLE WITH MILD-TO-MODERATE PD AND WILL COMPARE THESE EFFECTS WITH THOSE OF STRETCHING AND RESISTANCE TRAINING EXERCISES. METHODS: A COMMUNITY-BASED, SINGLE-BLIND, RANDOMIZED TRIAL WILL BE CONDUCTED. A TOTAL OF 126 SUBJECTS WILL BE RECRUITED AND RANDOMLY DIVIDED INTO YOGA (N = 63) OR STRETCHING AND RESISTANCE EXERCISE (N = 63) GROUPS. FOR 8 WEEKS, THE YOGA GROUP WILL RECEIVE A WEEKLY 90-MIN SESSION OF YOGA, AND THE CONTROL GROUP WILL RECEIVE A WEEKLY 60-MIN SESSION OF STRETCHING AND RESISTANCE EXERCISES. THE PRIMARY OUTCOME WILL BE THE LEVEL OF PSYCHOLOGICAL DISTRESS MEASURED USING THE HOSPITAL ANXIETY AND DEPRESSION SCALE. THE SECONDARY OUTCOMES WILL INCLUDE THE SEVERITY OF MOTOR SYMPTOMS MEASURED BY THE MOVEMENT DISORDERS SOCIETY - UNIFIED PARKINSON'S DISEASE SCALE - PART III MOTOR EXAMINATION; MOBILITY, BALANCE, AND FALL RISK MEASURED BY THE TIMED UP AND GO TEST; SPIRITUAL WELLBEING MEASURED BY THE HOLISTIC WELLBEING SCALE; AND HRQOL MEASURED BY THE PARKINSON'S DISEASE QUESTIONNAIRE-8. ASSESSMENT WILL BE CONDUCTED AT BASELINE, 8TH, AND 20TH WEEKS OF FOLLOW-UPS. DISCUSSION: THIS STUDY WILL BE THE FIRST RANDOMIZED TRIAL TO COMPARE THE EFFECT OF YOGA VERSUS STRETCHING AND RESISTANCE TRAINING EXERCISES IN A PD POPULATION. RESULTS WILL CONTRIBUTE TO THE VALUE OF YOGA AS A THERAPEUTIC OPTION FOR MANAGING PSYCHOLOGICAL DISTRESS IN PD PATIENTS. MULTIPLE OUTCOMES INCLUDING PSYCHOLOGICAL, PHYSIOLOGICAL, AND SPIRITUAL AND HRQOL WILL ALSO BE MEASURED TO ELUCIDATE THE POTENTIAL MECHANISMS OF YOGA. THE EFFECT OF YOGA ON PEOPLE WITH CHRONIC ILLNESSES WILL FURTHER BE ELUCIDATED. THIS INFORMATION SHOULD CONTRIBUTE TO FUTURE RESEARCH, PRACTICE, AND POLICY RELATED TO PD MANAGEMENT. TRIAL REGISTRATION: WHO PRIMARY REGISTRY - CHINESE CLINICAL TRIALS REGISTRY (CHICTR): CUHK_CCRB00522 REGISTERED ON 8 OCTOBER 2016; DATE OF APPROVAL 19 AUGUST 2016.	2017	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
8 2454  36 YOGA AS A COMPLEMENTARY THERAPY FOR METABOLIC SYNDROME: A NARRATIVE REVIEW. METABOLIC SYNDROME (MS) IS ASSOCIATED WITH A SEDENTARY AND STRESSFUL LIFESTYLE AND AFFECTS UNDERACTIVE PEOPLE DISPROPORTIONATELY. YOGA IS CONSIDERED TO BE A LOW-IMPACT MIND-BODY STRESS-RELIEVING EXERCISE, AND RESEARCHERS ARE INCREASING THEIR FOCUS ON THE BENEFITS OF YOGA FOR MANAGING METABOLIC DISORDERS. IT IS ALSO IMPORTANT FOR PHYSICIANS AND HEALTH CARE PROFESSIONALS TO UNDERSTAND THE THERAPEUTIC EFFICACY OF YOGA INTERVENTION, IN TERMS OF ITS TYPE, DURATION AND FREQUENCY ON VARIOUS MS RISK FACTORS. THE PRESENT REVIEW SUMMARIZES THE CURRENT SCIENTIFIC UNDERSTANDING OF THE EFFECTS OF YOGA ON MS RISK FACTORS SUCH AS GLUCOSE HOMEOSTASIS MARKERS, LIPID PROFILE, ADIPOCYTOKINES AND CARDIOVASCULAR RISK FACTORS, AND DISCUSSES THE POSSIBLE MECHANISMS OF ACTION. MEDLINE, PUBMED, SCOPUS AND COCHRANE LIBRARY WERE SEARCHED FROM THEIR INCEPTION UP TO DECEMBER 2019, USING THE KEYWORDS "METABOLIC SYNDROME," "DIABETES," "CARDIOVASCULAR DISEASES," "OBESITY" AND "YOGA." THE LITERATURE SUMMARIZED IN THIS REVIEW HAVE SHOWN MIXED EFFECTS OF YOGA ON MS RISK FACTORS AND DO NOT PROVIDE ROBUST EVIDENCE FOR ITS EFFICACY. MORE RIGOROUS RESEARCH AND WELL-DESIGNED TRIALS THAT HAVE A HIGHER STANDARD OF METHODOLOGY AND EVALUATE YOGA'S LONG-TERM IMPACTS ON MS ARE NEEDED. UNDERSTANDING YOGA'S BIOCHEMICAL AND MOLECULAR MECHANISMS OF ACTION ON VARIOUS METABOLIC PATHWAYS IS ALSO NEEDED.	2021	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
9 2850  56 YOGA, MINDFULNESS-BASED STRESS REDUCTION AND STRESS-RELATED PHYSIOLOGICAL MEASURES: A META-ANALYSIS. BACKGROUND AND OBJECTIVES: PRACTICES THAT INCLUDE YOGA ASANAS AND MINDFULNESS-BASED STRESS REDUCTION FOR THE MANAGEMENT OF STRESS ARE INCREASINGLY POPULAR; HOWEVER, THE NEUROBIOLOGICAL EFFECTS OF THESE PRACTICES ON STRESS REACTIVITY ARE NOT WELL UNDERSTOOD. MANY STUDIES INVESTIGATING THE EFFECTS OF SUCH PRACTICES FAIL TO INCLUDE AN ACTIVE CONTROL GROUP. GIVEN THE FREQUENCY WITH WHICH PEOPLE ARE SELECTING SUCH INTERVENTIONS AS A FORM OF SELF-MANAGEMENT, IT IS IMPORTANT TO DETERMINE THEIR EFFECTIVENESS. THUS, THIS REVIEW INVESTIGATES THE EFFECTS OF PRACTICES THAT INCLUDE YOGA ASANAS, WITH AND WITHOUT MINDFULNESS-BASED STRESS REDUCTION, COMPARED TO AN ACTIVE CONTROL, ON PHYSIOLOGICAL MARKERS OF STRESS. MATERIALS AND METHODS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMISED CONTROLLED TRIALS PUBLISHED IN ENGLISH COMPARED PRACTICES THAT INCLUDED YOGA ASANAS, WITH AND WITHOUT MINDFULNESS-BASED STRESS REDUCTION, TO AN ACTIVE CONTROL, ON STRESS-RELATED PHYSIOLOGICAL MEASURES. THE REVIEW FOCUSED ON STUDIES THAT MEASURED PHYSIOLOGICAL PARAMETERS SUCH AS BLOOD PRESSURE, HEART RATE, CORTISOL AND PERIPHERAL CYTOKINE EXPRESSION. MEDLINE, AMED, CINAHL, PSYCINFO, SOCINDEX, PUBMED, AND SCOPUS WERE SEARCHED IN MAY 2016 AND UPDATED IN DECEMBER 2016. RANDOMISED CONTROLLED TRIALS WERE INCLUDED IF THEY ASSESSED AT LEAST ONE OF THE FOLLOWING OUTCOMES: HEART RATE, BLOOD PRESSURE, HEART RATE VARIABILITY, MEAN ARTERIAL PRESSURE, C-REACTIVE PROTEIN, INTERLEUKINS OR CORTISOL. RISK OF BIAS ASSESSMENTS INCLUDED SEQUENCE GENERATION, ALLOCATION CONCEALMENT, BLINDING OF ASSESSORS, INCOMPLETE OUTCOME DATA, SELECTIVE OUTCOME REPORTING AND OTHER SOURCES OF BIAS. META-ANALYSIS WAS UNDERTAKEN USING COMPREHENSIVE META-ANALYSIS SOFTWARE VERSION 3. SENSITIVITY ANALYSES WERE PERFORMED USING 'ONE-STUDY-REMOVED' ANALYSIS. SUBGROUP ANALYSIS WAS CONDUCTED FOR DIFFERENT YOGA AND CONTROL GROUP TYPES, INCLUDING MINDFULNESS-BASED STRESS REDUCTION VERSUS NON-MINDFULNESS-BASED STRESS REDUCTION BASED INTERVENTIONS, DIFFERENT POPULATIONS, LENGTH OF INTERVENTION, AND METHOD OF DATA ANALYSIS. A RANDOM-EFFECTS MODEL WAS USED IN ALL ANALYSES. RESULTS: FORTY TWO STUDIES WERE INCLUDED IN THE META-ANALYSIS. INTERVENTIONS THAT INCLUDED YOGA ASANAS WERE ASSOCIATED WITH REDUCED EVENING CORTISOL, WAKING CORTISOL, AMBULATORY SYSTOLIC BLOOD PRESSURE, RESTING HEART RATE, HIGH FREQUENCY HEART RATE VARIABILITY, FASTING BLOOD GLUCOSE, CHOLESTEROL AND LOW DENSITY LIPOPROTEIN, COMPARED TO ACTIVE CONTROL. HOWEVER, THE REPORTED INTERVENTIONS WERE HETEROGENEOUS. CONCLUSIONS: PRACTICES THAT INCLUDE YOGA ASANAS APPEAR TO BE ASSOCIATED WITH IMPROVED REGULATION OF THE SYMPATHETIC NERVOUS SYSTEM AND HYPOTHALAMIC-PITUITARY-ADRENAL SYSTEM IN VARIOUS POPULATIONS.	2017	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
10 2025  47 SYSTEMATIC REVIEW OF YOGA INTERVENTIONS TO PROMOTE CARDIOVASCULAR HEALTH IN OLDER ADULTS. THE BENEFITS OF PHYSICAL ACTIVITY ARE WELL ESTABLISHED, YET FEW OLDER ADULTS ENGAGE IN ADEQUATE PHYSICAL ACTIVITY TO OPTIMIZE HEALTH. WHILE YOGA MAY REDUCE THE RISK OF CARDIOVASCULAR DISEASE, FEW STUDIES HAVE FOCUSED ON THE EFFICACY OF YOGA-BASED PHYSICAL ACTIVITY TO PROMOTE CARDIOVASCULAR HEALTH IN OLDER ADULTS. THE OBJECTIVE OF THIS REVIEW IS TO PROVIDE AN EVALUATION OF YOGA INTERVENTIONS TO REDUCE CARDIOVASCULAR RISK IN OLDER ADULTS. FOUR DATABASES WERE SEARCHED FOR RANDOMIZED CONTROLLED TRIALS OF YOGA INTERVENTIONS IN OLDER ADULTS. STUDIES WITH CARDIOVASCULAR OUTCOMES WERE INCLUDED. LITERATURE SEARCHES IDENTIFIED NINE ARTICLES ELIGIBLE FOR REVIEW. SIGNIFICANT HEALTH BENEFITS WERE REPORTED, INCLUDING FAVORABLE CHANGES IN BLOOD PRESSURE, BODY COMPOSITION, GLUCOSE, AND LIPIDS. YOGA PRACTICES, PARTICIPANT CHARACTERISTICS, AND OUTCOME MEASURES WERE VARIABLE. THERE WAS LIMITED USE OF THEORY. YOGA IS SAFE AND FEASIBLE IN OLDER ADULTS; ADDITIONAL RESEARCH IS WARRANTED TO EXAMINE THE SPECIFIC COMPONENTS OF YOGA INTERVENTIONS ESSENTIAL TO REDUCING CARDIOVASCULAR RISK.	2016	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
11 2371  32 WHAT HAS NEUROIMAGING TAUGHT US ON THE NEUROBIOLOGY OF YOGA? A REVIEW. YOGA IS BECOMING INCREASINGLY POPULAR WORLDWIDE, WITH SEVERAL IMPLICATED PHYSICAL AND MENTAL BENEFITS. HERE WE PROVIDE A COMPREHENSIVE AND CRITICAL REVIEW OF THE RESEARCH GENERATED FROM THE EXISTING NEUROIMAGING LITERATURE IN STUDIES OF YOGA PRACTITIONERS. WE REVIEWED 34 INTERNATIONAL PEER-REVIEWED NEUROIMAGING STUDIES OF YOGA USING MAGNETIC RESONANCE IMAGING (MRI), POSITRON EMISSION TOMOGRAPHY (PET), OR SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY (SPECT): 11 MORPHOLOGICAL AND 26 FUNCTIONAL STUDIES, INCLUDING THREE STUDIES THAT WERE CLASSIFIED AS BOTH MORPHOLOGICAL AND FUNCTIONAL. CONSISTENT FINDINGS INCLUDE INCREASED GRAY MATTER VOLUME IN THE INSULA AND HIPPOCAMPUS, INCREASED ACTIVATION OF PREFRONTAL CORTICAL REGIONS, AND FUNCTIONAL CONNECTIVITY CHANGES MAINLY WITHIN THE DEFAULT MODE NETWORK. THERE IS QUITE SOME VARIABILITY IN THE NEUROIMAGING FINDINGS THAT PARTIALLY REFLECTS DIFFERENT YOGA STYLES AND APPROACHES, AS WELL AS SAMPLE SIZE LIMITATIONS. DIRECT COMPARATOR GROUPS SUCH AS PHYSICAL ACTIVITY ARE SCARCELY USED SO FAR. FINALLY, HYPOTHESES ON THE UNDERLYING NEUROBIOLOGY DERIVED FROM THE IMAGING FINDINGS ARE DISCUSSED IN THE LIGHT OF THE POTENTIAL BENEFICIAL EFFECTS OF YOGA.	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
12 1404  54 IMPACT OF YOGA ON COGNITION AND MENTAL HEALTH AMONG ELDERLY: A SYSTEMATIC REVIEW. BACKGROUND: COGNITIVE DECLINE AND PSYCHOLOGICAL HEALTH PROBLEMS ARE THE MOST FREQUENTLY OBSERVED AND UNDER-TREATED ISSUES AMONG THE ELDERLY. MANY STUDIES HAVE ASSESSED THE EFFICACY OF YOGA ON COGNITIVE AND MENTAL HEALTH PARAMETERS AMONG THE ELDERLY. HOWEVER, UP TO DATE, THERE IS NO SYSTEMATIC REVIEW DONE TO EVALUATE THE ROLE OF YOGA-BASED INTERVENTIONS ON COGNITION AND MENTAL HEALTH IN THE ELDERLY. OBJECTIVE: THIS REVIEW EVALUATES THE BENEFICIAL EFFECT OF YOGA IN IMPROVING COGNITIVE AND MENTAL HEALTH IN THE ELDERLY. METHODOLOGY: A COMPREHENSIVE SEARCH HAS PERFORMED ON MEDLINE, GOOGLE SCHOLAR, PUBMED, AND PSYCINFO ELECTRONIC DATABASE FROM THEIR INCEPTION TO JANUARY 2019. THE LITERATURE SEARCH WAS CONSTRUCTED AROUND SEARCH TERM FOR "MENTAL HEALTH", "COGNITION", "YOGA" AND "ELDERLY". OUT OF 3388 RECORDS, WE WERE CONSIDERED ONLY RANDOMIZED CONTROL TRIALS (RCTS) WITH YOGA-BASED INTERVENTIONS ON THE OLDER PEOPLE FOR THIS REVIEW. RISK OF BIAS WAS ASSESSED USING DELPHI LIST AND PEDRO CRITERIA. RESULTS: AFTER FILTERING OUT IRRELEVANT STUDIES, IN OUR SEARCH, WE COME ACROSS 13 RCTS, AND THEY INCLUDED IN THIS SYSTEMATIC REVIEW. OF 13 RCTS, FOUR STUDIES ASSESSED ONLY COGNITIVE PARAMETERS AND FIVE STUDIES ASSESSED ONLY PSYCHOLOGICAL PARAMETERS, AND FOUR STUDIES EVALUATED BOTH. STUDY QUALITY WAS FAIR TO MODERATE OF INCLUDED RCTS ON THE DELPHI LIST AND PEDRO CRITERIA. MAXIMUM STUDIED VARIABLES IN COGNITION WERE EXECUTIVE FUNCTIONS, MEMORY, ATTENTION, AND LANGUAGE WHILE IN MENTAL HEALTH DEPRESSION, ANXIETY, STRESS, AND MOOD. YOGA-BASED INTERVENTIONS HAVE SOME BENEFICIAL EFFECTS ON ATTENTION, EXECUTIVE FUNCTIONS AMONG COGNITIVE VARIABLES, AND DEPRESSION AMONG MENTAL HEALTH PARAMETERS AMONG THE ELDERLY. CONCLUSION: THE PRESENT REVIEW INDICATES THAT YOGA-BASED INTERVENTIONS HAVE SOME POSITIVE EVIDENCE IN IMPROVING ATTENTION, EXECUTIVE FUNCTIONS AND MEMORY OF COGNITION, WHILE DEPRESSION IN MENTAL HEALTH COMPARED TO ACTIVE CONTROL AMONG THE ELDERLY. HOWEVER, METHODOLOGICAL LIMITATIONS AND SMALL NUMBER OF STUDIES PRECLUDE CONFIRMING THE POTENTIAL BENEFITS OF YOGA-BASED INTERVENTIONS ON COGNITION AND MENTAL HEALTH AMONG THE ELDERLY. FURTHER, THIS REVIEW STRONGLY RECOMMENDS MORE RANDOMIZED CONTROL TRIALS WITH STANDARD STUDY METHODOLOGY, USE OF VALIDATED MODULES OF YOGA INTERVENTION, AND LONG TERM FOLLOW UP TO HAVE DEFINITE CONCLUSIONS.	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
13 1936  37 ROLE OF YOGA IN THE PREVENTION AND MANAGEMENT OF VARIOUS CARDIOVASCULAR DISEASES AND THEIR RISK FACTORS: A COMPREHENSIVE SCIENTIFIC EVIDENCE-BASED REVIEW. CARDIOVASCULAR DISEASES (CVDS) ARE A GROUP OF DISORDERS OF THE HEART AND BLOOD VESSELS. CVDS ARE THE LEADING CAUSE OF DEATHS WORLDWIDE. THOUGH YOGA IS GAINING POPULARITY AS A THERAPY, ESPECIALLY IN CVD PATIENTS, THERE IS A LACK OF A COMPREHENSIVE REVIEW REPORTING ITS ROLE IN THE MANAGEMENT OF VARIOUS CVDS AND THEIR RISK FACTORS. THUS, WE PERFORMED A COMPREHENSIVE LITERATURE SEARCH IN THE PUBMED/MEDLINE ELECTRONIC DATABASE. AN AGGREGATE OF 603 ARTICLES PUBLISHED FROM INCEPTION WERE SCREENED AND 85 ARTICLES THAT ARE APPLICABLE WERE REPORTED. THIS REVIEW SUGGESTS THAT YOGA MAY PLAY A ROLE AS AN ADJUVANT IN THE MANAGEMENT OF VARIOUS CVDS AND THEIR RISK FACTORS. HOWEVER, MANY STUDIES HAD A SMALL SAMPLE SIZE, DIFFERENT TYPES AND DURATIONS OF THE YOGA INTERVENTIONS, AND DID NOT PROVIDE THE DETAILS OF MECHANISMS BEHIND THE IMPROVEMENTS. THUS, FURTHER STUDIES ARE WARRANTED TO EXPLORE THE MECHANISMS OF THE IMPACTS OF YOGA.	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
14 2416  39 YOGA AND MEDITATION IN CARDIOVASCULAR DISEASE. YOGA IS A HOLISTIC MIND-BODY INTERVENTION AIMED AT PHYSICAL, MENTAL, EMOTIONAL AND SPIRITUAL WELL BEING. SEVERAL STUDIES HAVE SHOWN THAT YOGA AND/OR MEDITATION CAN CONTROL RISK FACTORS FOR CARDIOVASCULAR DISEASE LIKE HYPERTENSION, TYPE II DIABETES AND INSULIN RESISTANCE, OBESITY, LIPID PROFILE, PSYCHOSOCIAL STRESS AND SMOKING. SOME RANDOMIZED STUDIES SUGGEST THAT YOGA/MEDITATION COULD RETARD OR EVEN REGRESS EARLY AND ADVANCED CORONARY ATHEROSCLEROSIS. A RECENT STUDY SUGGESTS THAT TRANSCENDENTAL MEDITATION MAY BE EXTREMELY USEFUL IN SECONDARY PREVENTION OF CORONARY HEART DISEASE AND MAY REDUCE CARDIOVASCULAR EVENTS BY 48% OVER A 5-YEAR PERIOD. ANOTHER SMALL STUDY SUGGESTS THAT YOGA MAY BE HELPFUL IN PREVENTION OF ATRIAL FIBRILLATION. HOWEVER, MOST STUDIES HAVE SEVERAL LIMITATIONS LIKE LACK OF ADEQUATE CONTROLS, SMALL SAMPLE SIZE, INCONSISTENCIES IN BASELINE AND DIFFERENT METHODOLOGIES, ETC. AND THEREFORE LARGE TRIALS WITH IMPROVED METHODOLOGIES ARE REQUIRED TO CONFIRM THESE FINDINGS. HOWEVER, IN VIEW OF THE EXISTING KNOWLEDGE AND YOGA BEING A COST-EFFECTIVE TECHNIQUE WITHOUT SIDE EFFECTS, IT APPEARS APPROPRIATE TO INCORPORATE YOGA/MEDITATION FOR PRIMARY AND SECONDARY PREVENTION OF CARDIOVASCULAR DISEASE.	2014	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
15 2539  70 YOGA FOR ADULTS WITH TYPE 2 DIABETES: A SYSTEMATIC REVIEW OF CONTROLLED TRIALS. A GROWING BODY OF EVIDENCE SUGGESTS YOGIC PRACTICES MAY BENEFIT ADULTS WITH TYPE 2 DIABETES (DM2). IN THIS SYSTEMATIC REVIEW, WE EVALUATE AVAILABLE EVIDENCE FROM PROSPECTIVE CONTROLLED TRIALS REGARDING THE EFFECTS OF YOGA-BASED PROGRAMS ON SPECIFIC HEALTH OUTCOMES PERTINENT TO DM2 MANAGEMENT. TO IDENTIFY QUALIFYING STUDIES, WE SEARCHED NINE DATABASES AND SCANNED BIBLIOGRAPHIES OF RELEVANT REVIEW PAPERS AND ALL IDENTIFIED ARTICLES. CONTROLLED TRIALS THAT DID NOT TARGET ADULTS WITH DIABETES, INCLUDED ONLY ADULTS WITH TYPE 1 DIABETES, WERE UNDER TWO-WEEK DURATION, OR DID NOT INCLUDE QUANTITATIVE OUTCOME DATA WERE EXCLUDED. STUDY QUALITY WAS EVALUATED USING THE PEDRO SCALE. THIRTY-THREE PAPERS REPORTING FINDINGS FROM 25 CONTROLLED TRIALS (13 NONRANDOMIZED, 12 RANDOMIZED) MET OUR INCLUSION CRITERIA (N = 2170 PARTICIPANTS). COLLECTIVELY, FINDINGS SUGGEST THAT YOGIC PRACTICES MAY PROMOTE SIGNIFICANT IMPROVEMENTS IN SEVERAL INDICES OF IMPORTANCE IN DM2 MANAGEMENT, INCLUDING GLYCEMIC CONTROL, LIPID LEVELS, AND BODY COMPOSITION. MORE LIMITED DATA SUGGEST THAT YOGA MAY ALSO LOWER OXIDATIVE STRESS AND BLOOD PRESSURE; ENHANCE PULMONARY AND AUTONOMIC FUNCTION, MOOD, SLEEP, AND QUALITY OF LIFE; AND REDUCE MEDICATION USE IN ADULTS WITH DM2. HOWEVER, GIVEN THE METHODOLOGICAL LIMITATIONS OF EXISTING STUDIES, ADDITIONAL HIGH-QUALITY INVESTIGATIONS ARE REQUIRED TO CONFIRM AND FURTHER ELUCIDATE THE POTENTIAL BENEFITS OF YOGA PROGRAMS IN POPULATIONS WITH DM2.	2016	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
16  477  58 CLINICAL APPLICATIONS OF YOGA FOR THE PEDIATRIC POPULATION: A SYSTEMATIC REVIEW. OBJECTIVE: THE AIM OF THIS STUDY WAS TO EVALUATE THE EVIDENCE FOR CLINICAL APPLICATIONS OF YOGA AMONG THE PEDIATRIC POPULATION. METHODS: WE CONDUCTED AN ELECTRONIC LITERATURE SEARCH INCLUDING CINAHL, COCHRANE CENTRAL REGISTER OF CONTROLLED TRIALS (CENTRAL), EMBASE, MEDLINE, PSYCINFO, AND MANUAL SEARCH OF RETRIEVED ARTICLES FROM INCEPTION OF EACH DATABASE UNTIL DECEMBER 2008. RANDOMIZED CONTROLLED TRIALS (RCTS) AND NONRANDOMIZED CONTROLLED TRIALS (NRCTS) WERE SELECTED THAT INCLUDED YOGA OR YOGA-BASED INTERVENTIONS FOR INDIVIDUALS AGED 0 TO 21 YEARS. DATA WERE EXTRACTED AND ARTICLES CRITICALLY REVIEWED USING A MODIFIED JADAD SCORE AND DESCRIPTIVE METHODOLOGICAL CRITERIA, WITH SUMMARIZATION IN TABLES. RESULTS: THIRTY-FOUR CONTROLLED STUDIES PUBLISHED FROM 1979 TO 2008 WERE IDENTIFIED, WITH 19 RCTS AND 15 NRCTS. MANY STUDIES WERE OF LOW METHODOLOGICAL QUALITY. CLINICAL AREAS FOR WHICH YOGA HAS BEEN STUDIED INCLUDE PHYSICAL FITNESS, CARDIORESPIRATORY EFFECTS, MOTOR SKILLS/STRENGTH, MENTAL HEALTH AND PSYCHOLOGICAL DISORDERS, BEHAVIOR AND DEVELOPMENT, IRRITABLE BOWEL SYNDROME, AND BIRTH OUTCOMES FOLLOWING PRENATAL YOGA. NO ADVERSE EVENTS WERE REPORTED IN TRIALS REVIEWED. ALTHOUGH A LARGE MAJORITY OF STUDIES WERE POSITIVE, METHODOLOGICAL LIMITATIONS SUCH AS RANDOMIZATION METHODS, WITHDRAWAL/DROPOUTS, AND DETAILS OF YOGA INTERVENTION PRECLUDE CONCLUSIVE EVIDENCE. CONCLUSIONS: THERE ARE LIMITED DATA ON THE CLINICAL APPLICATIONS OF YOGA AMONG THE PEDIATRIC POPULATION. MOST PUBLISHED CONTROLLED TRIALS WERE SUGGESTIVE OF BENEFIT, BUT RESULTS ARE PRELIMINARY BASED ON LOW QUANTITY AND QUALITY OF TRIALS. FURTHER RESEARCH OF YOGA FOR CHILDREN BY USING A HIGHER STANDARD OF METHODOLOGY AND REPORTING IS WARRANTED.	2009	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
17 1661  61 NARRATIVE REVIEW OF YOGA INTERVENTION CLINICAL TRIALS INCLUDING WEIGHT-RELATED OUTCOMES. CONTEXT: MEDICAL AUTHORITIES HAVE IDENTIFIED OBESITY AS A CAUSAL FACTOR IN THE DEVELOPMENT OF DIABETES, HYPERTENSION, AND CARDIOVASCULAR DISEASE (CVD), AND MORE BROADLY, OF METABOLIC SYNDROME/INSULIN RESISTANCE SYNDROME. TO PROVIDE SOLUTIONS THAT CAN MODIFY THIS RISK FACTOR, RESEARCHERS NEED TO IDENTIFY METHODS OF EFFECTIVE RISK REDUCTION AND PRIMARY PREVENTION OF OBESITY. RESEARCH ON THE EFFECTIVENESS OF YOGA AS A TREATMENT FOR OBESITY IS LIMITED, AND STUDIES VARY IN OVERALL QUALITY AND METHODOLOGICAL RIGOR. OBJECTIVE: THIS NARRATIVE REVIEW ASSESSED THE QUANTITY AND QUALITY OF CLINICAL TRIALS OF YOGA AS AN INTERVENTION FOR WEIGHT LOSS OR AS A MEANS OF RISK REDUCTION OR TREATMENT FOR OBESITY AND DISEASES IN WHICH OBESITY IS A CAUSAL FACTOR. THIS REVIEW SUMMARIZED THE STUDIES' RESEARCH DESIGNS AND EVALUATED THE EFFICACY OF YOGA FOR WEIGHT LOSS VIA THE CURRENT EVIDENCE BASE. DESIGN: THE RESEARCH TEAM EVALUATED PUBLISHED STUDIES TO DETERMINE THE APPROPRIATENESS OF RESEARCH DESIGNS, COMPARABILITY OF PROGRAMS' INTERVENTION ELEMENTS, AND STANDARDIZATION OF OUTCOME MEASURES. THE RESEARCH TEAM'S LITERATURE SEARCH USED THE KEY TERMS YOGA AND OBESITY OR YOGA AND WEIGHT LOSS IN THREE PRIMARY MEDICAL-LITERATURE DATABASES (PUBMED, PSYCHINFO, AND WEB OF SCIENCE). THE STUDY EXCLUDED CLINICAL TRIALS WITH NO QUANTITATIVE OBESITY RELATED MEASURE. EXTRACTED DATA INCLUDED EACH STUDY'S (1) DESIGN; (2) SETTING AND POPULATION; (3) NATURE, DURATION, AND FREQUENCY OF INTERVENTIONS; (4) COMPARISON GROUPS; (5) RECRUITMENT STRATEGIES; (6) OUTCOME MEASURES; (7) DATA ANALYSIS AND PRESENTATION; AND (8) RESULTS AND CONCLUSIONS. THE RESEARCH TEAM DEVELOPED AN OVERALL EVALUATION PARAMETER TO COMPARE DISPARATE TRIALS. OUTCOME MEASURES: THE RESEARCH TEAM REVIEWED EACH STUDY TO DETERMINE ITS KEY FEATURES, EACH WORTH A SPECIFIED NUMBER OF POINTS, WITH A MAXIMUM TOTAL OF 20 POINTS. THE FEATURES INCLUDED A STUDY'S (1) DURATION, (2) FREQUENCY OF YOGA PRACTICE, (3) INTENSITY OF (LENGTH OF) EACH PRACTICE, (4) NUMBER OF YOGIC ELEMENTS, (5) INCLUSION OF DIETARY MODIFICATION, (6) INCLUSION OF A RESIDENTIAL COMPONENT, (7) THE NUMBER OF WEIGHT-RELATED OUTCOME MEASURES, AND (8) A DISCUSSION OF THE DETAILS OF THE YOGIC ELEMENTS. RESULTS: OVERALL, THERAPEUTIC YOGA PROGRAMS ARE FREQUENTLY EFFECTIVE IN PROMOTING WEIGHT LOSS AND/OR IMPROVEMENTS IN BODY COMPOSITION. THE EFFECTIVENESS OF YOGA FOR WEIGHT LOSS IS RELATED TO THE FOLLOWING KEY FEATURES: (1) AN INCREASED FREQUENCY OF PRACTICE; (2) A LONGER INTERVENTION DURATION (3) A YOGIC DIETARY COMPONENT; (4) A RESIDENTIAL COMPONENT; (5) THE COMPREHENSIVE INCLUSION OF YOGIC COMPONENTS; (5) AND A HOME-PRACTICE COMPONENT. CONCLUSIONS: YOGA APPEARS TO BE AN APPROPRIATE AND POTENTIALLY SUCCESSFUL INTERVENTION FOR WEIGHT MAINTENANCE, PREVENTION OF OBESITY, AND RISK REDUCTION FOR DISEASES IN WHICH OBESITY PLAYS A SIGNIFICANT CAUSAL ROLE.	2013	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
18  204  35 A REVIEW OF YOGA PROGRAMS FOR FOUR LEADING RISK FACTORS OF CHRONIC DISEASES. YOGA, A FORM OF PHYSICAL ACTIVITY, IS RAPIDLY GAINING IN POPULARITY AND HAS MANY HEALTH BENEFITS. YET HEALTHCARE PROVIDERS HAVE BEEN SLOW TO RECOGNIZE YOGA FOR ITS ABILITY TO IMPROVE HEALTH CONDITIONS, AND FEW INTERVENTIONS HAVE BEEN DEVELOPED THAT TAKE FULL ADVANTAGE OF ITS BENEFITS. THE PURPOSE OF THIS ARTICLE IS TO REVIEW PUBLISHED STUDIES USING YOGA PROGRAMS AND TO DETERMINE THE EFFECT OF YOGA INTERVENTIONS ON COMMON RISK FACTORS OF CHRONIC DISEASES (OVERWEIGHT, HYPERTENSION, HIGH GLUCOSE LEVEL AND HIGH CHOLESTEROL). A SYSTEMATIC SEARCH YIELDED 32 ARTICLES PUBLISHED BETWEEN 1980 AND APRIL 2007. THE STUDIES FOUND THAT YOGA INTERVENTIONS ARE GENERALLY EFFECTIVE IN REDUCING BODY WEIGHT, BLOOD PRESSURE, GLUCOSE LEVEL AND HIGH CHOLESTEROL, BUT ONLY A FEW STUDIES EXAMINED LONG-TERM ADHERENCE. ADDITIONALLY, NOT ENOUGH STUDIES INCLUDED DIVERSE POPULATIONS AT HIGH RISK FOR DIABETES AND ITS RELATED COMMON HEALTH PROBLEMS.	2007	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
19 1187  41 EVIDENCE BASED EFFECTS OF YOGA PRACTICE ON VARIOUS HEALTH RELATED PROBLEMS OF ELDERLY PEOPLE: A REVIEW. MORE THAN 50% OF THE ELDERLY ABOVE 60 YEARS OF AGE SUFFER FROM CHRONIC MEDICAL CONDITIONS, THE PREVALENCE OF WHICH INCREASES WITH AGE. THOUGH YOGA HAS BEEN REPORTED AS AN EFFECTIVE MODALITY IN IMPROVING VARIOUS PHYSICAL AND PSYCHOLOGICAL ASPECTS OF ELDERLY POPULATIONS, A COMPREHENSIVE REVIEW OF YOGA AND ITS EFFECTS ON VARIOUS HEALTH RELATED PROBLEMS OF ELDERLY POPULATIONS HAS NOT YET BEEN REPORTED. HENCE, WE PERFORMED PUBMED/MEDLINE SEARCH TO REVIEW RELEVANT ARTICLES, USING KEYWORD "YOGA AND ELDERLY". RELEVANT ARTICLES PUBLISHED SINCE INCEPTION TILL 6TH OCTOBER 2016 WERE INCLUDED FOR THE REVIEW. BASED ON THE AVAILABLE SCIENTIFIC LITERATURE, THIS REVIEW SUGGESTS THAT THE REGULAR PRACTICE OF YOGA CAN BE CONSIDERED AS AN EFFECTIVE INTERVENTION IN IMPROVING PHYSICAL (REDUCES HEART RATE, BLOOD PRESSURE, BLOOD GLUCOSE, OXIDATIVE DAMAGE, FATIGUE, WEAKNESS, FEAR OF FALL, AND IMPROVE HEART RATE VARIABILITY, BAROREFLEX SENSITIVITY, INSULIN SENSITIVITY, PHYSICAL FUNCTIONS, MOBILITY, FLEXIBILITY, AND URINARY INCONTINENCE), MENTAL (REDUCES DEPRESSION, ANXIETY), EMOTIONAL (REDUCES ANGER, STRESS, TENSION AND IMPROVE SELF-EFFICACY), SOCIAL (IMPROVE LIFE SATISFACTION), AND VITAL (IMPROVED VITALITY) PLANES OF ELDERLY INDIVIDUALS, OFFERING A BETTER QUALITY OF SLEEP AND QUALITY OF LIFE.	2017	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
20 2858  39 YOGA-BASED CARDIAC REHABILITATION: CURRENT PERSPECTIVES FROM RANDOMIZED CONTROLLED TRIALS IN CORONARY ARTERY DISEASE. CORONARY ARTERY DISEASE CARRIES A HIGH MORBIDITY AND MORTALITY WORLDWIDE, AND EXERCISE-BASED CARDIAC REHABILITATION PROGRAMMES PLAY A LARGE ROLE IN SECONDARY PREVENTION. EXERCISE-BASED REHABILITATION PROGRAMMES ARE EXPENSIVE, AND IN CERTAIN SUBGROUPS UPTAKE IS POOR. YOGA HAS BEEN SUGGESTED TO SHOW IMPROVEMENTS IN CARDIOVASCULAR HEALTH WHICH WOULD SUPPORT ITS USE IN CARDIAC REHABILITATION PROGRAMMES. WE CARRIED OUT A REVIEW OF CURRENT RANDOMIZED CONTROLLED TRIALS TO DETERMINE IF YOGA-BASED CARDIAC REHABILITATION LEADS TO REDUCED CARDIAC RISK FACTORS, AND IMPROVED PHYSIOLOGICAL AND PSYCHOLOGICAL OUTCOMES IN PATIENTS WITH CORONARY ARTERY DISEASE COMPARED TO STANDARD CARE. SIX RANDOMIZED CONTROLLED STUDIES WERE IDENTIFIED AFTER A MEDICAL DATABASE SEARCH, AND META-ANALYSIS WAS CARRIED OUT FOR THE DIFFERENT OUTCOMES. OVERALL, THE ADDITION OF YOGA TO STANDARD CARE RESULTED IN IMPROVED SUBJECTIVE FEELING OF CARDIAC HEALTH AND QUALITY OF LIFE. THERE WAS ALSO A TREND TOWARDS IMPROVEMENT IN LEFT VENTRICULAR SYSTOLIC FUNCTION. IMPROVEMENT IN CARDIAC RISK FACTORS, MACE AND PSYCHOLOGICAL HEALTH IN THIS COHORT HAS STILL TO BE PROVEN, BUT WAS NOT INFERIOR TO STANDARD OR ENHANCED CARE, AND THE BENEFITS BECAME MORE PRONOUNCED AT LONGER FOLLOW-UP. FUTURE STUDIES WITH LONGER FOLLOW-UP AND LARGER PATIENT NUMBERS WOULD AID IN ACCURATELY ASSESSING THE LONG-TERM BENEFIT OF YOGA-BASED REHABILITATION.	2021