1  327 133 ANTIDEPRESSANT EFFICACY OF SUDARSHAN KRIYA YOGA (SKY) IN MELANCHOLIA: A RANDOMIZED COMPARISON WITH ELECTROCONVULSIVE THERAPY (ECT) AND IMIPRAMINE. BACKGROUND: SUDARSHAN KRIYA YOGA (SKY) IS A PROCEDURE THAT INVOLVES ESSENTIALLY RHYTHMIC HYPERVENTILATION AT DIFFERENT RATES OF BREATHING. THE ANTIDEPRESSANT EFFICACY OF SKY WAS DEMONSTRATED IN DYSTHYMIA IN A PROSPECTIVE, OPEN CLINICAL TRIAL. THIS STUDY COMPARED THE RELATIVE ANTIDEPRESSANT EFFICACY OF SKY IN MELANCHOLIA WITH TWO OF THE CURRENT STANDARD TREATMENTS, ELECTROCONVULSIVE THERAPY (ECT) AND IMIPRAMINE (IMN). METHODS: CONSENTING, UNTREATED MELANCHOLIC DEPRESSIVES (N=45) WERE HOSPITALIZED AND RANDOMIZED EQUALLY INTO THREE TREATMENT GROUPS. THEY WERE ASSESSED AT RECRUITMENT AND WEEKLY THEREAFTER FOR FOUR WEEKS. RESULTS: SIGNIFICANT REDUCTIONS IN THE TOTAL SCORES ON BECK DEPRESSION INVENTORY (BDI) AND HAMILTON RATING SCALE FOR DEPRESSION (HRSD) OCCURRED ON SUCCESSIVE OCCASIONS IN ALL THREE GROUPS. THE GROUPS, HOWEVER, DID NOT DIFFER. SIGNIFICANT INTERACTION BETWEEN THE GROUPS AND OCCASION OF ASSESSMENT OCCURRED. AT WEEK THREE, THE SKY GROUP HAD HIGHER SCORES THAN THE ECT GROUP BUT WAS NOT DIFFERENT FROM THE IMN GROUP. REMISSION (TOTAL HRSD SCORE OF SEVEN OR LESS) RATES AT THE END OF THE TRIAL WERE 93, 73 AND 67% IN THE ECT, IMN AND SKY GROUPS, RESPECTIVELY. NO CLINICALLY SIGNIFICANT SIDE EFFECTS WERE OBSERVED. DISCUSSION: WITHIN THE LIMITATIONS OF THE DESIGN (LACK OF DOUBLE BLIND CONDITIONS), IT CAN BE CONCLUDED THAT, ALTHOUGH INFERIOR TO ECT, SKY CAN BE A POTENTIAL ALTERNATIVE TO DRUGS IN MELANCHOLIA AS A FIRST LINE TREATMENT.	2000	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
2  352  42 ASSESSMENT OF THE EFFECT OF MULABANDHA YOGA THERAPY IN HEALTHY WOMEN, STIGMATIZED FOR PELVIC FLOOR DYSFUNCTIONS: A RANDOMIZED CONTROLLED TRIAL. BACKGROUND: IN DEVELOPING COUNTRIES, WOMEN DO NOT REVEAL THEIR PERINEUM RELATED HEALTH ISSUES BECAUSE MOST OF THE TIME THEY ARE STIGMATIZED BY THE SOCIETY. MULTIPARITY, MOSTLY FOUND IN WOMEN OF RURAL AREAS IS ONE OF THE MAJOR CAUSES OF PELVIC FLOOR DYSFUNCTIONS (PFDS) LIKE PELVIC ORGAN PROLAPSE, URINARY INCONTINENCE, RECTAL INCONTINENCE, ETC. USUALLY, THEY VISIT HEALTH CENTRES IN THE ADVANCED STAGE OF DISEASES, AND THEN MEDICAL TREATMENT IS NOT THE ONLY CHOICE LEFT. MANY RESEARCH STUDIES SHOW THAT YOGA PRACTICES PROMOTE HEALTH CONDITIONS, CONTRIBUTE TO ENHANCING ENDURANCE, FLEXIBILITY, AND MUSCULAR STRENGTH, AND IMPROVING QUALITY OF LIFE. OBJECTIVE(S): THE STUDY WAS CONDUCTED TO ASSESS THE IMPACT OF MULABANDHA YOGA THERAPY (MYT) IN HEALTHY WOMAN PARTICIPANTS AS A PREVENTIVE MEASURE. MATERIAL AND METHODS: THE STUDY WAS A PROSPECTIVE AND RANDOMIZED CONTROLLED TRIAL. FIFTY HEALTHY WOMAN PARTICIPANTS WERE ALLOCATED IN TWO GROUPS VIZ., MYT GROUP AND NO MYT GROUP. MULABANDHA YOGA WAS CONDUCTED FOR THE MYT GROUP FOR 12 WEEKS. NO MYT GROUP WAS ADVISED NOT TO DO YOGA. PELVIC FLOOR MUSCLE STRENGTH WAS INTERNALLY EVALUATED BY EMPLOYING THE PERFECT SCHEME SCORE (P = POWER, E = ENDURANCE, R = REPETITIONS, F = FAST CONTRACTIONS, ECT = EVERY CONTRACTION TIMED). FOR ELIGIBLE SAMPLES, MYT SESSIONS WERE HELD FOR 12 WEEKS. DATA INTERPRETATION WAS DONE WITH SPSS SOFTWARE 20.0 (IBM CORP. RELEASED 2011. IBM SPSS STATISTICS FOR WINDOWS, VERSION 20.0. ARMONK, NY, USA). RESULTS: FIFTY HEALTHY WOMAN PARTICIPANTS WERE ALLOCATED FOR ANALYSIS. THERE WAS NO STATISTICALLY SIGNIFICANT DIFFERENCE IN BETWEEN THE GROUPS COMPARISON IN TERMS OF AGE, SOCIO-ECONOMIC STATUS, OCCUPATION, EDUCATION, PARITY AND MODE OF DELIVERY. PERFECT SCHEME SCORE SIGNIFICANTLY IMPROVED IN PARTICIPANTS AFTER 12 WEEKS OF REGULAR MYT. NO STATISTICALLY SIGNIFICANT DIFFERENCES WERE OBSERVED BETWEEN THE GROUPS COMPARISON IN TERMS OF PERFECT SCHEME SCORE. CONCLUSION: THE CURRENT STUDY SHOWS THAT REGULAR PRACTICE OF MYT FOR 12 WEEKS IS A BETTER MEANS TO REINFORCE THE STRENGTH OF PELVIC FLOOR MUSCLES IN WOMEN. THIS MYT PROCEDURE WILL ESTABLISH EVIDENCE FOR WOMEN WHO ARE RELUCTANT TOWARDS THEIR PELVIC ORGAN-RELATED ISSUES. WOMEN MUST INCORPORATE THE MYT PRACTICE IN THEIR ROUTINE LIFE AS A PREVENTIVE MEASURE TO REFRAIN FROM PELVIC FLOOR DYSFUNCTIONS.	2021	

3   99  45 A PATIENT WITH ELECTROCONVULSIVE THERAPY-RESISTANT MAJOR DEPRESSIVE DISORDER WITH A FULL RESPONSE TO HEATED YOGA: A CASE REPORT. DEPRESSION REMAINS DIFFICULT TO TREAT AS A RESULT OF LESS THAN OPTIMAL EFFICACY AND TROUBLESOME SIDE EFFECTS OF ANTIDEPRESSANTS. THE AUTHORS PRESENT THE CASE OF A PATIENT WITH TREATMENT-RESISTANT DEPRESSION WITH MELANCHOLIC FEATURES WHO HAD PREVIOUSLY BEEN UNRESPONSIVE TO ELECTROCONVULSIVE THERAPY (ECT) PLUS AN ANTIDEPRESSANT REGIMEN BUT WHOSE CONDITION FULLY REMITTED WITH THE ADDITION OF A STANDARDIZED FORM OF HEATED HATHA YOGA (HY; BIKRAM YOGA) PRACTICED IN A ROOM HEATED TO 105 DEGREES F. THE PATIENT WAS A 28-YEAR-OLD WOMAN WHO UNDERWENT 8 WEEKS OF HY AS PART OF A RANDOMIZED CONTROLLED TRIAL OF HY FOR DEPRESSION WHILE CONTINUING HER ANTIDEPRESSANT TREATMENT. THE PATIENT WAS ASKED TO ATTEND A MINIMUM OF 2 WEEKLY, 90-MINUTE HY CLASSES. AFTER 8 WEEKS (12 CLASSES IN TOTAL), THE PATIENT NO LONGER MET THE CRITERIA FOR A MAJOR DEPRESSIVE EPISODE WITH MELANCHOLIC FEATURES, PER MINI-INTERNATIONAL NEUROPSYCHIATRIC INTERVIEW (MINI) CRITERIA. HER DEPRESSIVE SYMPTOMS HAD IMPROVED DRAMATICALLY, WITH INVENTORY OF DEPRESSIVE SYMPTOMATOLOGY, CLINICIAN-RATED (IDS-C30), AND HAMILTON DEPRESSION RATING SCALE (HAM-D28) SCORES DECREASING FROM 28 AT BASELINE TO 3, AND FROM 28 AT BASELINE TO 4, RESPECTIVELY, INDICATING REMISSION. THIS PATIENT'S ECT-RESISTANT DEPRESSION REMITTED WITH THE ADDITION OF HY TO HER ANTIDEPRESSANT REGIMEN. BECAUSE OF HER YOUTH AND ATHLETICISM, THIS PATIENT WAS LIKELY WELL SUITED TO THIS RIGOROUS FORM OF YOGA. FURTHER RESEARCH IS NEEDED TO EXPLORE HY AS A POTENTIAL INTERVENTION FOR TREATMENT-RESISTANT DEPRESSION.	2021	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
4  733  43 EFFECT OF MULA BANDHA YOGA IN MILD GRADE PELVIC ORGAN PROLAPSE: A RANDOMIZED CONTROLLED TRIAL. BACKGROUND: PELVIC ORGAN PROLAPSE IS THE GROWING HEALTH ISSUE RELATED TO WOMEN OF THE REPRODUCTIVE AND POSTMENOPAUSAL AGE GROUP IN INDIA AND ACROSS THE GLOBE. TREATMENT OPTION FOR PELVIC ORGAN PROLAPSE INCLUDES BOTH SURGICAL AND NON-SURGICAL INTERVENTION. THE DEVELOPMENT OF PELVIC ORGAN PROLAPSE IS AN INDICATION FOR MAJOR SURGERY AMONG 20% OF ALL WOMEN. NEVERTHELESS, THE RECURRENCE OF PELVIC ORGAN PROLAPSE IS DETECTED AMONG 58% OF THE PATIENT AFTER SURGERY. THIS HIGHLIGHTS THE NEED FOR PREVENTIVE MEASURES FOR REDUCING THE IMPACT OF PELVIC ORGAN PROLAPSE. AIMS AND OBJECTIVE: TO STUDY THE EFFECT OF 3 MONTHS YOGA THERAPY IN FEMALE PATIENTS SUFFERING FROM MILD PELVIC ORGAN PROLAPSE. MATERIAL AND METHODS: 50 PARTICIPANTS WERE ALLOCATED INTO TWO GROUPS (25 IN EACH GROUP) BY GENERATING RANDOM ALLOCATION SEQUENCE. WOMEN AGED 20-60 WITH SYMPTOMATIC MILD PELVIC ORGAN PROLAPSE IN THE YOGA GROUP WERE OFFERED MULABANDHA YOGA THERAPY ALONG WITH OTHER CONVENTIONAL TREATMENT MODALITIES, WHILE THE CONTROL GROUP WAS ONLY ON CONVENTIONAL TREATMENT. ALL PARTICIPANTS GAVE WRITTEN INFORMED CONSENT. AN ASSESSMENT WAS DONE BY IMPROVEMENT IN CHIEF COMPLAINTS AND PELVIC FLOOR DISTRESS INVENTORY-20 (PFDI-20) & PELVIC FLOOR IMPACT QUESTIONNAIRE-7 (PFIQ-7) AT BASELINE AND AT THE END OF 4, 8 & 12 WEEKS. RESULTS AT THE END OF 12 WEEKS, POST-STUDY COMPARISON BETWEEN THE TWO GROUPS SHOWED A SIGNIFICANT IMPROVEMENT IN CHIEF COMPLAINTS LIKE PERENNIAL PAIN, P/V DISCHARGE, PERINEAL MUSCLE LAXITY AND FEELING OF SOMETHING COMING OUT P/V (P < 0.001). PARTICIPANTS IN THE YOGA GROUP IMPROVED BY (ON AVERAGE) 5.7 (95% CONFIDENCE INTERVAL 3.1 TO 14.7) POINTS MORE ON THE PFDI-20 THAN DID PARTICIPANTS IN THE CONTROL GROUP (P = 0.1) AND A MEAN SCORE OF PFIQ-7 WAS ALSO IMPROVED SIGNIFICANTLY. CONCLUSIONS: ALTHOUGH MULABANDHA (ROOT LOCK) YOGA THERAPY LED TO A SIGNIFICANTLY GREATER IMPROVEMENT IN PFDI-20 & PFIQ-7 SCORES THE DIFFERENCE BETWEEN THE GROUPS WAS BELOW THE PRESUMED LEVEL OF CLINICAL RELEVANCE (15 POINTS). MORE STUDIES ARE NEEDED TO IDENTIFY FACTORS RELATED TO THE SUCCESS OF MULABANDHA (ROOT LOCK) YOGA THERAPY AND TO INVESTIGATE LONG-TERM EFFECTS.	2018	
                                                                                                                                                                                                                                     
5 1694  35 P300 AMPLITUDE AND ANTIDEPRESSANT RESPONSE TO SUDARSHAN KRIYA YOGA (SKY). BACKGROUND: THERE IS EVIDENCE THAT SUDARSHAN KRIYA YOGA (SKY) HAS SIGNIFICANT ANTIDEPRESSANT EFFECTS. OBJECTIVE: THE PRESENT STUDY EXAMINED WHETHER PRETREATMENT P300 ERP AMPLITUDE PREDICTS ANTIDEPRESSANT RESPONSE TO SKY. METHODS: CONSENTING, DRUG-FREE DEPRESSED PATIENTS (N = 30; DYSTHYMICS, 15, MELANCHOLICS, 15) WHO RECEIVED SKY AS THE SOLE TREATMENT WERE ASSESSED CLINICALLY AT PRETREATMENT, 1 MONTH AND 3 MONTHS. AUDITORY P300 WAS RECORDED BEFORE TREATMENT. RESULTS: TWENTY-TWO PATIENTS RESPONDED FAVOURABLY TO SKY. THE PRETREATMENT P300 AMPLITUDE NEITHER DISTINGUISHED RESPONDERS AND NON-RESPONDERS NOR WAS ASSOCIATED WITH DIFFERENTIAL RATES OF RESPONSE. DISCUSSION: IT IS CONCLUDED THAT SKY THERAPY IS UNIFORMLY EFFECTIVE REGARDLESS OF THE PRETREATMENT P300 AMPLITUDE.	1998	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
6  326  53 ANTIDEPRESSANT EFFICACY AND HORMONAL EFFECTS OF SUDARSHANA KRIYA YOGA (SKY) IN ALCOHOL DEPENDENT INDIVIDUALS. BACKGROUND: SUDARSHANA KRIYA YOGA (SKY) HAS DEMONSTRABLE ANTIDEPRESSANT EFFECTS. SKY WAS TESTED FOR THIS EFFECT IN INPATIENTS OF ALCOHOL DEPENDENCE. METHODS: FOLLOWING A WEEK OF DETOXIFICATION MANAGEMENT CONSENTING SUBJECTS (N=60) WERE EQUALLY RANDOMIZED TO RECEIVE SKY THERAPY OR NOT (CONTROLS) FOR A TWO-WEEK STUDY. SKY THERAPY INCLUDED ALTERNATE DAY PRACTICE OF SPECIFIED BREATHING EXERCISE UNDER SUPERVISION OF A TRAINED THERAPIST. SUBJECTS COMPLETED THE BECK DEPRESSION INVENTORY (BDI) BEFORE AND AFTER THE TWO WEEKS OF THIS INTERVENTION. MORNING PLASMA CORTISOL, ACTH AND PROLACTIN TOO WERE MEASURED BEFORE AND AT THE END OF TWO WEEKS. RESULTS: IN BOTH GROUPS REDUCTIONS IN BDI SCORES OCCURRED BUT SIGNIFICANTLY MORE SO IN SKY GROUP. LIKEWISE, IN BOTH GROUPS PLASMA CORTISOL AS WELL AS ACTH FELL AFTER TWO WEEKS BUT SIGNIFICANTLY MORE SO IN SKY GROUP. REDUCTION IN BDI SCORES CORRELATED WITH THAT IN CORTISOL IN SKY BUT NOT IN CONTROL GROUP. LIMITATIONS: ANTIDEPRESSANT EFFECTS OF SKY WERE DEMONSTRATED IN EARLY ABSTINENCE THAT ALSO HAD SUBSTANTIAL SPONTANEOUS IMPROVEMENT. IT IS NOT KNOWN IF THIS EFFECT CONTRIBUTES TO SUSTAINED ABSTINENCE. CONCLUSION: RESULTS EXTEND THE ANTIDEPRESSANT EFFECTS OF SKY IN ALCOHOL DEPENDENCE SUBJECTS. REDUCTION IN STRESS-HORMONE LEVELS (CORTISOL AND ACTH) ALONG WITH BDI REDUCTIONS POSSIBLY SUPPORT A BIOLOGICAL MECHANISM OF SKY IN PRODUCING BENEFICIAL EFFECTS.	2006	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
7  360  37 ASSOCIATION OF YOGA PRACTICE AND SERUM CORTISOL LEVELS IN CHRONIC PERIODONTITIS PATIENTS WITH STRESS-RELATED ANXIETY AND DEPRESSION. AIM: REDUCING THE PSYCHOSOCIAL STRESS BY VARIOUS METHODS CAN IMPROVE OVERALL HEALTH, AND YOGA IS NOW CONSIDERED AS AN EASILY AVAILABLE ALTERNATIVE METHOD. THE PRESENT CROSS-SECTIONAL PILOT STUDY WAS CONDUCTED MAINLY TO FIND THE ASSOCIATION OF YOGA PRACTICE WITH PERIODONTAL DISEASE BY MEASURING SERUM CORTISOL LEVELS. MATERIALS AND METHODS: A TOTAL OF 70 SUBJECTS WITH AGE RANGE OF 35-60 YEARS SUFFERING WITH CHRONIC PERIODONTITIS WERE DIVIDED INTO GROUP I (WITH STRESS), GROUP II (WITHOUT STRESS), AND GROUP III (PRACTICING YOGA). PSYCHOLOGICAL EVALUATION WAS CARRIED OUT USING HAMILTON ANXIETY RATING SCALE (HAM-A) AND ZUNG SELF-RATING DEPRESSION SCALE (ZSDS). PERIODONTAL PARAMETERS LIKE PLAQUE INDEX (PI), PROBING POCKET DEPTH (PPD), AND CLINICAL ATTACHMENT LEVEL (CAL) AT 5-8 MM AND >8 MM WERE RECORDED. BLOOD SAMPLES WERE COLLECTED AND SERUM CORTISOL LEVELS WERE MEASURED. RESULTS: MEAN AGE, PLAQUE SCORES, AND NUMBER OF TEETH WITH PPD AND CAL AT 5-8 MM AND >8 MM WERE SIMILAR IN ALL THE GROUPS, EXCEPT BETWEEN GROUP I AND GROUP III WHERE A MULTIPLE COMPARISON WITH TUKEY'S POST-HOC TEST SHOWED SIGNIFICANT DIFFERENCE IN PLAQUE INDEX (P < 0.038) AND THE NUMBER OF TEETH WITH CAL 5-8 MM (P < 0.016). SERUM CORTISOL LEVELS AND HAM-A SCALE AND ZSDS SCORES SHOWED HIGHLY SIGNIFICANT VALUE (P < 0.001) IN GROUP I SUBJECTS WHEN COMPARED WITH GROUP II AND GROUP III SUBJECTS. CONCLUSION: CROSS-SECTIONAL OBSERVATION DONE AMONG THREE GROUPS SHOWED THAT INDIVIDUALS PRACTICING YOGA REGULARLY HAD LOW SERUM CORTISOL LEVELS, HAM-A SCALE AND ZSDS SCORES, AND BETTER PERIODONTAL HEALTH.	2016	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
8 2325  44 TREATMENT OF MAJOR DEPRESSIVE DISORDER WITH IYENGAR YOGA AND COHERENT BREATHING: A RANDOMIZED CONTROLLED DOSING STUDY. OBJECTIVES: THE AIMS OF THIS STUDY WERE TO ASSESS THE EFFECTS OF AN INTERVENTION OF IYENGAR YOGA AND COHERENT BREATHING AT FIVE BREATHS PER MINUTE ON DEPRESSIVE SYMPTOMS AND TO DETERMINE OPTIMAL INTERVENTION YOGA DOSING FOR FUTURE STUDIES IN INDIVIDUALS WITH MAJOR DEPRESSIVE DISORDER (MDD). METHODS: SUBJECTS WERE RANDOMIZED TO THE HIGH-DOSE GROUP (HDG) OR LOW-DOSE GROUP (LDG) FOR A 12-WEEK INTERVENTION OF THREE OR TWO INTERVENTION CLASSES PER WEEK, RESPECTIVELY. ELIGIBLE SUBJECTS WERE 18-64 YEARS OLD WITH MDD, HAD BASELINE BECK DEPRESSION INVENTORY-II (BDI-II) SCORES >/=14, AND WERE EITHER ON NO ANTIDEPRESSANT MEDICATIONS OR ON A STABLE DOSE OF ANTIDEPRESSANTS FOR >/=3 MONTHS. THE INTERVENTION INCLUDED 90-MIN CLASSES PLUS HOMEWORK. OUTCOME MEASURES WERE BDI-II SCORES AND INTERVENTION COMPLIANCE. RESULTS: FIFTEEN HDG (MAGE = 38.4 +/- 15.1 YEARS) AND 15 LDG (MAGE = 34.7 +/- 10.4 YEARS) SUBJECTS COMPLETED THE INTERVENTION. BDI-II SCORES AT SCREENING AND COMPLIANCE DID NOT DIFFER BETWEEN GROUPS (P = 0.26). BDI-II SCORES DECLINED SIGNIFICANTLY FROM SCREENING (24.6 +/- 1.7) TO WEEK 12 (6.0 +/- 3.8) FOR THE HDG (-18.6 +/- 6.6; P < 0.001), AND FROM SCREENING (27.7 +/- 2.1) TO WEEK 12 (10.1 +/- 7.9) IN THE LDG (-17.7 +/- 9.3; P < 0.001). THERE WERE NO SIGNIFICANT DIFFERENCES BETWEEN GROUPS, BASED ON RESPONSE (I.E., >50% DECREASE IN BDI-II SCORES; P = 0.65) FOR THE HDG (13/15 SUBJECTS) AND LDG (11/15 SUBJECTS) OR REMISSION (I.E., NUMBER OF SUBJECTS WITH BDI-II SCORES <14; P = 1.00) FOR THE HDG (14/15 SUBJECTS) AND LDG (13/15 SUBJECTS) AFTER THE 12-WEEK INTERVENTION, ALTHOUGH A GREATER NUMBER OF SUBJECTS IN THE HDG HAD 12-WEEK BDI-II SCORES </=10 (P = 0.04). CONCLUSION: DURING THIS 12-WEEK INTERVENTION OF YOGA PLUS COHERENT BREATHING, DEPRESSIVE SYMPTOMS DECLINED SIGNIFICANTLY IN PATIENTS WITH MDD IN BOTH THE HDG AND LDG. BOTH GROUPS SHOWED COMPARABLE COMPLIANCE AND CLINICAL IMPROVEMENTS, WITH MORE SUBJECTS IN THE HDG EXHIBITING BDI-II SCORES </=10 AT WEEK 12.	2017	
                                                                                                                                                                                                                                                                                                                                                                              
9 1130  36 EFFICACY OF YOGA FOR DEPRESSED POSTPARTUM WOMEN: A RANDOMIZED CONTROLLED TRIAL. BACKGROUND: UP TO 20% OF WOMEN EXPERIENCE POSTPARTUM DEPRESSION (PPD). PPD IS ASSOCIATED WITH ANXIETY AND POOR HEALTH-RELATED QUALITY OF LIFE (HRQOL). EFFICACIOUS TREATMENTS ARE CRITICAL; MANY WOMEN WITH PPD PREFER COMPLEMENTARY THERAPIES. THUS, THE CURRENT STUDY EXAMINED YOGA AS A COMPLEMENTARY THERAPY FOR PPD. METHODS: FIFTY-SEVEN POSTPARTUM WOMEN WITH SCORES >/=12 ON THE HAMILTON DEPRESSION RATING SCALE WERE RANDOMLY ASSIGNED TO A YOGA (N = 28) OR WAIT-LIST CONTROL (N = 29) GROUP. THE YOGA INTERVENTION CONSISTED OF 16 CLASSES OVER 8 WEEKS. OUTCOMES WERE DEPRESSION, ANXIETY, AND HRQOL. RESULTS: THE YOGA GROUP EXPERIENCED SIGNIFICANTLY GREATER RATE OF IMPROVEMENT IN DEPRESSION, ANXIETY, AND HRQOL, RELATIVE TO THE CONTROL GROUP WITH MODERATE TO LARGE EFFECTS. RELIABLE CHANGE INDEX ANALYSES REVEALED THAT 78% OF WOMEN IN THE YOGA GROUP EXPERIENCED CLINICALLY SIGNIFICANT CHANGE. CONCLUSION: THESE FINDINGS SUPPORT YOGA AS A PROMISING COMPLEMENTARY THERAPY FOR PPD, AND WARRANT LARGE-SCALE REPLICATION STUDIES. TRIAL REGISTRATION: HTTP://CLINICALTRIALS.GOV/NCT02213601.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
10 2857  38 YOGA-BASED CARDIAC REHABILITATION AFTER ACUTE MYOCARDIAL INFARCTION: A RANDOMIZED TRIAL. BACKGROUND: GIVEN THE SHORTAGE OF CARDIAC REHABILITATION (CR) PROGRAMS IN INDIA AND POOR UPTAKE WORLDWIDE, THERE IS AN URGENT NEED TO FIND ALTERNATIVE MODELS OF CR THAT ARE INEXPENSIVE AND MAY OFFER CHOICE TO SUBGROUPS WITH POOR UPTAKE (E.G., WOMEN AND ELDERLY). OBJECTIVES: THIS STUDY SOUGHT TO EVALUATE THE EFFECTS OF YOGA-BASED CR (YOGA-CARE) ON MAJOR CARDIOVASCULAR EVENTS AND SELF-RATED HEALTH IN A MULTICENTER RANDOMIZED CONTROLLED TRIAL. METHODS: THE TRIAL WAS CONDUCTED IN 24 MEDICAL CENTERS ACROSS INDIA. THIS STUDY RECRUITED 3,959 PATIENTS WITH ACUTE MYOCARDIAL INFARCTION WITH A MEDIAN AND MINIMUM FOLLOW-UP OF 22 AND 6 MONTHS. PATIENTS WERE INDIVIDUALLY RANDOMIZED TO RECEIVE EITHER A YOGA-CARE PROGRAM (N = 1,970) OR ENHANCED STANDARD CARE INVOLVING EDUCATIONAL ADVICE (N = 1,989). THE CO-PRIMARY OUTCOMES WERE: 1) FIRST OCCURRENCE OF MAJOR ADVERSE CARDIOVASCULAR EVENTS (MACE) (COMPOSITE OF ALL-CAUSE MORTALITY, MYOCARDIAL INFARCTION, STROKE, OR EMERGENCY CARDIOVASCULAR HOSPITALIZATION); AND 2) SELF-RATED HEALTH ON THE EUROPEAN QUALITY OF LIFE-5 DIMENSIONS-5 LEVEL VISUAL ANALOGUE SCALE AT 12 WEEKS. RESULTS: MACE OCCURRED IN 131 (6.7%) PATIENTS IN THE YOGA-CARE GROUP AND 146 (7.4%) PATIENTS IN THE ENHANCED STANDARD CARE GROUP (HAZARD RATIO WITH YOGA-CARE: 0.90; 95% CONFIDENCE INTERVAL [CI]: 0.71 TO 1.15; P = 0.41). SELF-RATED HEALTH WAS 77 IN YOGA-CARE AND 75.7 IN THE ENHANCED STANDARD CARE GROUP (BASELINE-ADJUSTED MEAN DIFFERENCE IN FAVOR OF YOGA-CARE: 1.5; 95% CI: 0.5 TO 2.5; P = 0.002). THE YOGA-CARE GROUP HAD GREATER RETURN TO PRE-INFARCT ACTIVITIES, BUT THERE WAS NO DIFFERENCE IN TOBACCO CESSATION OR MEDICATION ADHERENCE BETWEEN THE TREATMENT GROUPS (SECONDARY OUTCOMES). CONCLUSIONS: YOGA-CARE IMPROVED SELF-RATED HEALTH AND RETURN TO PRE-INFARCT ACTIVITIES AFTER ACUTE MYOCARDIAL INFARCTION, BUT THE TRIAL LACKED STATISTICAL POWER TO SHOW A DIFFERENCE IN MACE. YOGA-CARE MAY BE AN OPTION WHEN CONVENTIONAL CR IS UNAVAILABLE OR UNACCEPTABLE TO INDIVIDUALS. (A STUDY ON EFFECTIVENESS OF YOGA BASED CARDIAC REHABILITATION PROGRAMME IN INDIA AND UNITED KINGDOM; CTRI/2012/02/002408).	2020	
                                                                                                                                                                                                                                                                         
11 2318  47 TREATING MAJOR DEPRESSION WITH YOGA: A PROSPECTIVE, RANDOMIZED, CONTROLLED PILOT TRIAL. BACKGROUND: CONVENTIONAL PHARMACOTHERAPIES AND PSYCHOTHERAPIES FOR MAJOR DEPRESSION ARE ASSOCIATED WITH LIMITED ADHERENCE TO CARE AND RELATIVELY LOW REMISSION RATES. YOGA MAY OFFER AN ALTERNATIVE TREATMENT OPTION, BUT RIGOROUS STUDIES ARE FEW. THIS RANDOMIZED CONTROLLED TRIAL WITH BLINDED OUTCOME ASSESSORS EXAMINED AN 8-WEEK HATHA YOGA INTERVENTION AS MONO-THERAPY FOR MILD-TO-MODERATE MAJOR DEPRESSION. METHODS: INVESTIGATORS RECRUITED 38 ADULTS IN SAN FRANCISCO MEETING CRITERIA FOR MAJOR DEPRESSION OF MILD-TO-MODERATE SEVERITY, PER STRUCTURED PSYCHIATRIC INTERVIEW AND SCORES OF 14-28 ON BECK DEPRESSION INVENTORY-II (BDI). AT SCREENING, INDIVIDUALS ENGAGED IN PSYCHOTHERAPY, ANTIDEPRESSANT PHARMACOTHERAPY, HERBAL OR NUTRACEUTICAL MOOD THERAPIES, OR MIND-BODY PRACTICES WERE EXCLUDED. PARTICIPANTS WERE 68% FEMALE, WITH MEAN AGE 43.4 YEARS (SD = 14.8, RANGE = 22-72), AND MEAN BDI SCORE 22.4 (SD = 4.5). TWENTY PARTICIPANTS WERE RANDOMIZED TO 90-MINUTE HATHA YOGA PRACTICE GROUPS TWICE WEEKLY FOR 8 WEEKS. EIGHTEEN PARTICIPANTS WERE RANDOMIZED TO 90-MINUTE ATTENTION CONTROL EDUCATION GROUPS TWICE WEEKLY FOR 8 WEEKS. CERTIFIED YOGA INSTRUCTORS DELIVERED BOTH INTERVENTIONS AT A UNIVERSITY CLINIC. PRIMARY OUTCOME WAS DEPRESSION SEVERITY, MEASURED BY BDI SCORES EVERY 2 WEEKS FROM BASELINE TO 8 WEEKS. SECONDARY OUTCOMES WERE SELF-EFFICACY AND SELF-ESTEEM, MEASURED BY SCORES ON THE GENERAL SELF-EFFICACY SCALE (GSES) AND ROSENBERG SELF-ESTEEM SCALE (RSES) AT BASELINE AND AT 8 WEEKS. RESULTS: IN INTENT-TO-TREAT ANALYSIS, YOGA PARTICIPANTS EXHIBITED SIGNIFICANTLY GREATER 8-WEEK DECLINE IN BDI SCORES THAN CONTROLS (P-VALUE = 0.034). IN SUB-ANALYSES OF PARTICIPANTS COMPLETING FINAL 8-WEEK MEASURES, YOGA PARTICIPANTS WERE MORE LIKELY TO ACHIEVE REMISSION, DEFINED PER FINAL BDI SCORE </= 9 (P-VALUE = 0.018). EFFECT SIZE OF YOGA IN REDUCING BDI SCORES WAS LARGE, PER COHEN'S D = -0.96 [95%CI, -1.81 TO -0.12]. INTERVENTION GROUPS DID NOT DIFFER SIGNIFICANTLY IN 8-WEEK CHANGE SCORES FOR EITHER THE GSES OR RSES. CONCLUSION: IN ADULTS WITH MILD-TO-MODERATE MAJOR DEPRESSION, AN 8-WEEK HATHA YOGA INTERVENTION RESULTED IN STATISTICALLY AND CLINICALLY SIGNIFICANT REDUCTIONS IN DEPRESSION SEVERITY. TRIAL REGISTRATION: CLINICALTRIALS.GOV NCT01210651.	2017	
                                                                                                                           
12   91  47 A MULTICOMPONENT YOGA-BASED, BREATH INTERVENTION PROGRAM AS AN ADJUNCTIVE TREATMENT IN PATIENTS SUFFERING FROM GENERALIZED ANXIETY DISORDER WITH OR WITHOUT COMORBIDITIES. OBJECTIVES: THE AIM OF THIS STUDY IS TO EVALUATE THE EFFICACY AND TOLERABILITY OF SUDARSHAN KRIYA YOGA (SKY) COURSE IN GENERALIZED ANXIETY DISORDER (GAD) OUTPATIENTS, WHO AFTER EIGHT WEEKS OF AN APPROPRIATE DOSE OF TRADITIONAL THERAPY HAD NOT YET ACHIEVED REMISSION. SUBJECTS: THE ADULT PARTICIPANTS (18-65 YEARS) WERE OUTPATIENTS WITH A PRIMARY DIAGNOSIS OF GAD WITH OR WITHOUT COMORBIDITIES ON THE MINI-INTERNATIONAL NEUROPSYCHIATRIC INTERVIEW (MINI). PARTICIPANTS HAD A MINIMUM OF EIGHT WEEKS STANDARD TREATMENT WITH AN APPROPRIATE DOSE OF A STANDARD PRESCRIPTION ANXIOLYTIC, A CLINICIAN GLOBAL IMPRESSION-SEVERITY (CGI-S) SCORE OF 5-7, A HAMILTON ANXIETY SCALE (HAM-A) TOTAL SCORE >/=20 INCLUDING A SCORE OF >2 ON THE ANXIOUS MOOD AND TENSION ITEMS. MATERIALS AND METHODS: FORTY-ONE PATIENTS WERE ENROLLED IN AN OPEN-LABEL TRIAL OF THE SKY COURSE AS AN ADJUNCT TO STANDARD TREATMENT OF GAD AT THE START CLINIC FOR MOOD AND ANXIETY DISORDERS, A TERTIARY CARE MOOD AND ANXIETY DISORDER CLINIC IN TORONTO. THE SKY COURSE WAS ADMINISTERED OVER FIVE DAYS (22 H TOTAL). SUBJECTS WERE ENCOURAGED TO PRACTICE THE YOGA BREATHING TECHNIQUES AT HOME FOR 20 MIN PER DAY AFTER THE COURSE AND WERE OFFERED GROUP PRACTICE SESSIONS FOR 2 H ONCE A WEEK LED BY CERTIFIED YOGA INSTRUCTORS. THE PRIMARY OUTCOME MEASURE WAS THE MEAN CHANGE FROM PRE-TREATMENT ON THE HAM-A SCALE. PSYCHOLOGICAL MEASURES WERE OBTAINED AT BASELINE AND FOUR WEEKS AFTER COMPLETING THE INTERVENTION. RESULTS: THIRTY-ONE PATIENTS COMPLETED THE PROGRAM (MEAN AGE 42.6 +/- 13.3 YEARS). AMONG COMPLETERS, SIGNIFICANT REDUCTIONS OCCURRED IN THE PRE- AND POST-INTERVENTION MEAN HAM-A TOTAL SCORE (T=4.59; P<0.01) AND PSYCHIC SUBSCALE (T=5.00; P</=0.01). THE RESPONSE RATE WAS 73% AND THE REMISSION RATE 41% AS MEASURED ON THE HAM-A. CONCLUSION: THE RESULTS OF THIS SMALL PILOT TRIAL SUGGEST THAT THE SKY COURSE REPRESENTS A POTENTIALLY VALUABLE ADJUNCT TO STANDARD PHARMACOTHERAPY IN PATIENTS WITH GAD OR TREATMENT-RESISTANT GAD, AND WARRANTS FURTHER INVESTIGATION. IN PARTICULAR, CHANGES IN WORRY AND BODY SYMPTOMS SHOWED SIGNIFICANT IMPROVEMENTS THAT MAY FURTHER OUR UNDERSTANDING OF THE MECHANISM OF CHANGE IN THE TOLERANCE OF ANXIETY AND WORRY.	2012	
                                                                                             
13  168  39 A RANDOMIZED CONTROLLED DOSING STUDY OF IYENGAR YOGA AND COHERENT BREATHING FOR THE TREATMENT OF MAJOR DEPRESSIVE DISORDER: IMPACT ON SUICIDAL IDEATION AND SAFETY FINDINGS. BACKGROUND: YOGA INTERVENTIONS OFFER PROMISE FOR THE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD), YET THEIR SAFETY AND POTENTIAL IMPACT ON SUICIDAL IDEATION (SI) HAVE NOT BEEN WELL DOCUMENTED. THIS STUDY EVALUATED THE SAFETY OF A RANDOMIZED CONTROLLED DOSE-FINDING TRIAL OF IYENGAR YOGA PLUS COHERENT BREATHING FOR INDIVIDUALS WITH MDD, AS WELL AS THE POTENTIAL EFFECTS OF THE INTERVENTION ON SI WITHOUT INTENT. METHODS: PARTICIPANTS WITH BECK DEPRESSION INVENTORY-II (BDI-II) SCORES >/=14 AND A DIAGNOSIS OF MDD (USING DSM-IV CRITERIA) WERE RANDOMIZED TO EITHER A LOW DOSE GROUP (LDG) OR HIGH DOSE GROUP (HDG) AND RECEIVED A 12-WEEK MANUALIZED INTERVENTION. THE LDG INCLUDED TWO 90-MIN YOGA CLASSES PLUS THREE 30-MIN HOMEWORK SESSIONS WEEKLY. THE HDG OFFERED THREE 90-MIN CLASSES PLUS FOUR 30-MIN HOMEWORK SESSIONS WEEKLY. RESULTS: THIRTY-TWO INDIVIDUALS WITH MDD WERE RANDOMIZED, OF WHICH 30 COMPLETED THE PROTOCOL. AT SCREENING, SI WITHOUT INTENT WAS ENDORSED ON THE BDI-II BY 9 PARTICIPANTS; AFTER COMPLETING THE INTERVENTION, 8 OUT OF 9 REPORTED RESOLUTION OF SI. THERE WERE 17 ADVERSE EVENTS POSSIBLY-RELATED AND 15 DEFINITELY-RELATED TO THE INTERVENTION. THE MOST COMMON PROTOCOL-RELATED ADVERSE EVENT WAS MUSCULOSKELETAL PAIN, WHICH RESOLVED OVER THE COURSE OF THE STUDY. CONCLUSIONS: THE IYENGAR YOGA PLUS COHERENT BREATHING INTERVENTION WAS ASSOCIATED WITH THE RESOLUTION OF SI IN 8 OUT OF 9 PARTICIPANTS, WITH MILD SIDE EFFECTS THAT WERE PRIMARILY MUSCULOSKELETAL IN NATURE. THIS PRELIMINARY EVIDENCE SUGGESTS THAT THIS INTERVENTION MAY REDUCE SI WITHOUT INTENT AND BE SAFE FOR USE IN THOSE WITH MDD.	2018	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
14   74  36 A GROUP-BASED YOGA THERAPY INTERVENTION FOR URINARY INCONTINENCE IN WOMEN: A PILOT RANDOMIZED TRIAL. OBJECTIVE: THE AIM OF THIS STUDY IS TO EXAMINE THE FEASIBILITY, EFFICACY, AND SAFETY OF A GROUP-BASED YOGA THERAPY INTERVENTION FOR MIDDLE-AGED AND OLDER WOMEN WITH URINARY INCONTINENCE. METHODS: WE CONDUCTED A PILOT RANDOMIZED TRIAL OF AMBULATORY WOMEN AGED 40 YEARS AND OLDER WITH STRESS, URGENCY, OR MIXED-TYPE INCONTINENCE. WOMEN WERE RANDOMIZED TO A 6-WEEK YOGA THERAPY PROGRAM (N = 10) CONSISTING OF TWICE WEEKLY GROUP CLASSES AND ONCE WEEKLY HOME PRACTICE OR A WAIT-LIST CONTROL GROUP (N = 9). ALL PARTICIPANTS ALSO RECEIVED WRITTEN PAMPHLETS ABOUT STANDARD BEHAVIORAL SELF-MANAGEMENT STRATEGIES FOR INCONTINENCE. CHANGES IN INCONTINENCE WERE ASSESSED WITH 7-DAY VOIDING DIARIES. RESULTS: THE MEAN (SD) AGE WAS 61.4 (8.2) YEARS, AND THE MEAN BASELINE FREQUENCY OF INCONTINENCE WAS 2.5 (1.3) EPISODES/D. AFTER 6 WEEKS, THE TOTAL INCONTINENCE FREQUENCY DECREASED BY 70% (1.8 [0.9] FEWER EPISODES/D) IN THE YOGA THERAPY VERSUS 13% (0.3 [1.7] FEWER EPISODES/D) IN THE CONTROL GROUP (P = 0.049). PARTICIPANTS IN THE YOGA THERAPY GROUP ALSO REPORTED AN AVERAGE OF 71% DECREASE IN STRESS INCONTINENCE FREQUENCY (0.7 [0.8] FEWER EPISODES/D) COMPARED WITH A 25% INCREASE IN CONTROLS (0.2 [1.1] MORE EPISODES/D) (P = 0.039). NO SIGNIFICANT DIFFERENCES IN REDUCTION IN URGENCY INCONTINENCE WERE DETECTED BETWEEN THE YOGA THERAPY VERSUS CONTROL GROUPS (1.0 [1.0] VERSUS 0.5 [0.5] FEWER EPISODES/D; P = 0.20). ALL WOMEN STARTING THE YOGA THERAPY PROGRAM COMPLETED AT LEAST 90% OF THE GROUP CLASSES AND PRACTICE SESSIONS. TWO PARTICIPANTS IN EACH GROUP REPORTED ADVERSE EVENTS UNRELATED TO THE INTERVENTION. CONCLUSIONS: FINDINGS PROVIDE PRELIMINARY EVIDENCE TO SUPPORT THE FEASIBILITY, EFFICACY, AND SAFETY OF A GROUP-BASED YOGA THERAPY INTERVENTION TO IMPROVE URINARY INCONTINENCE IN WOMEN.	2014	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
15 1482  25 INTEGRATING YOGA THERAPY IN THE MANAGEMENT OF URINARY INCONTINENCE: A CASE REPORT. A 63-YEAR-OLD OVERWEIGHT FEMALE PREDIAGNOSED OF STRESS URINARY INCONTINENCE PRESENTED WITH EXACERBATED EVENTS OF URINE LEAKAGE. SHE WAS ADVISED A RESIDENTIAL LIFESTYLE AND BEHAVIORAL PROGRAM, PRIMARILY CONSISTING OF A MONITORED YOGA THERAPY MODULE, APART FROM HER ONGOING ANTICHOLINERGIC MEDICINE, FOR 21 DAYS. ASSESSMENTS WERE BASED ON A FREQUENCY VOLUME CHART, A BLADDER DIARY FOR THE ENTIRE DURATION OF TREATMENT, AND THE INTERNATIONAL CONSULTATION ON INCONTINENCE MODULAR QUESTIONNAIRE-URINARY INCONTINENCE SHORT FORM QUESTIONNAIRE ON THE DAYS OF ADMISSION AND DISCHARGE. A TOTAL OF 1.9 KG OF WEIGHT LOSS WAS OBSERVED DURING HER STAY. USAGE OF PAD, AS REPORTED IN HER DIARY, REDUCED FROM 3 TO 1 PER DAY. HER INTERNATIONAL CONSULTATION ON INCONTINENCE MODULAR QUESTIONNAIRE-URINARY INCONTINENCE SHORT FORM SCORE REDUCED FROM 16 TO 9, INDICATING BETTER CONTINENCE. SHE EXPRESSED SUBJECTIVE WELL-BEING AND CONFIDENCE IN HER SOCIAL INTERACTIONS. THIS IS PROBABLY THE FIRST CASE REPORT DEMONSTRATING FEASIBILITY OF INTEGRATION OF YOGA THERAPY IN THE MANAGEMENT OF URINARY INCONTINENCE.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
16  325  59 ANTI-ANXIETY EFFICACY OF SUDARSHAN KRIYA YOGA IN GENERAL ANXIETY DISORDER: A MULTICOMPONENT, YOGA BASED, BREATH INTERVENTION PROGRAM FOR PATIENTS SUFFERING FROM GENERALIZED ANXIETY DISORDER WITH OR WITHOUT COMORBIDITIES. BACKGROUND: SURDASHAN KRIYA YOGA (SKY) IS A PROCEDURE THAT IN VARIOUS STUDIES, HAS SHOWN EVIDENCES OF EFFICACY IN ALLEVIATING DEPRESSION AND ANXIETY DISORDERS, BUT IN EUROPE AND USA IT HAS NOT BEEN STUDIED YET ON A CAUCASIAN POPULATION AS AN ADJUNCT THERAPY FOR PSYCHIATRIC DISORDERS. METHODS: THE STUDY INVOLVED A SAMPLE OF CONSENTING WOMEN AND MEN (N = 69) WHO RECEIVED SKY THERAPY FOR A SIX-MONTH TIME PERIOD. THEY WERE ASSESSED AT RECRUITMENT, AFTER TWO WEEKS, AFTER THREE MONTHS AND AFTER SIX MONTHS USING HAMILTON RATING SCALE FOR ANXIETY (HRSA), HAMILTON RATING SCALE FOR DEPRESSION (HRSD), ZUNG SELF-RATING ANXIETY SCALE (ZSAS), ZUNG SELF-RATING DEPRESSION SCALE (ZSDS) AND SYMPTOM CHECKLIST-90 (SCL-90). RESULTS: ALL THE ANALYSES HAVE SHOWN THAT SKY THERAPY SIGNIFICANTLY REDUCES THE SCORES OF ANXIETY AND DEPRESSION. THIS IS PLAIN, ESPECIALLY AFTER THE INITIAL SKY TREATMENT, WHICH IS FOLLOWED BY A LONG PLATEAU PHASE THAT SEEMS TO VERGE ON NO ANXIETY/DEPRESSION SCORES. IT WAS FOUND THAT SKY EFFECTS LEAD TO A SIGNIFICANT CONVERGENCE BETWEEN THE SELF-ASSESSMENT (ZUNG SELF-RATING SCALE) AND HETERO-ASSESSMENT (HAMILTON RATING SCALE). LIMITATIONS: THE STUDY SHOULD BE REPLICATED ON A LARGER CLINICAL SAMPLE IN A CONTROLLED TRIAL TO LEARN MORE ABOUT THE EFFECTIVENESS OF SKY PROTOCOL. CONCLUSIONS: PARTICIPATION IN SKY ADJUNCT THERAPY TEN DAYS INTENSE WORKSHOP AND FOLLOW-UPS, COUPLED WITH DAILY INDIVIDUAL AND INDEPENDENT PRACTICE OF A SIMPLIFIED PROTOCOL OF BREATHING TECHNIQUES (30 MIN), CAN LEAD TO SIGNIFICANT REDUCTION IN LEVELS OF ANXIETY AND DEPRESSION.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
17 2169  37 THE EFFECTS OF YOGA IN PREVENTION OF PREGNANCY COMPLICATIONS IN HIGH-RISK PREGNANCIES: A RANDOMIZED CONTROLLED TRIAL. OBJECTIVE: WHILE PREVIOUS STUDIES HAVE SHOWN THE POTENTIAL EFFECTS OF YOGA IN NORMAL PREGNANCIES, THIS RANDOMIZED CONTROLLED TRIAL INVESTIGATED THE EFFECTS OF YOGA IN PREVENTION OF PREGNANCY COMPLICATIONS IN HIGH-RISK PREGNANCIES FOR THE FIRST TIME. METHODS: 68 HIGH-RISK PREGNANT WOMEN WERE RECRUITED FROM TWO MATERNITY HOSPITALS IN BENGALURU, INDIA AND WERE RANDOMIZED INTO YOGA AND CONTROL GROUPS. THE YOGA GROUP (N=30) RECEIVED STANDARD CARE PLUS ONE-HOUR YOGA SESSIONS, THREE TIMES A WEEK, FROM THE 12TH TO THE 28TH WEEK OF GESTATION. THE CONTROL GROUP (N=38) RECEIVED STANDARD CARE PLUS CONVENTIONAL ANTENATAL EXERCISES (WALKING) DURING THE SAME PERIOD. RESULTS: SIGNIFICANTLY FEWER PREGNANCY INDUCED HYPERTENSION (PIH), PREECLAMPSIA, GESTATIONAL DIABETES (GDM) AND INTRAUTERINE GROWTH RESTRICTION (IUGR) CASES WERE OBSERVED IN THE YOGA GROUP (P=0.018, 0.042, 0.049, 0.05 RESPECTIVELY). SIGNIFICANTLY FEWER SMALL FOR GESTATIONAL AGE (SGA) BABIES AND NEWBORNS WITH LOW APGAR SCORES (P=0.006) WERE BORN IN THE YOGA GROUP (P=0.033). CONCLUSION: THIS FIRST RANDOMIZED STUDY OF YOGA IN HIGH-RISK PREGNANCY HAS SHOWN THAT YOGA CAN POTENTIALLY BE AN EFFECTIVE THERAPY IN REDUCING HYPERTENSIVE RELATED COMPLICATIONS OF PREGNANCY AND IMPROVING FETAL OUTCOMES. ADDITIONAL DATA IS NEEDED TO CONFIRM THESE RESULTS AND BETTER EXPLAIN THE MECHANISM OF ACTION OF YOGA IN THIS IMPORTANT AREA.	2012	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
18 1831  43 PSYCHOLOGICAL FUNCTION, IYENGAR YOGA, AND COHERENT BREATHING: A RANDOMIZED CONTROLLED DOSING STUDY. BACKGROUND: EVIDENCE SUGGESTS THAT YOGA MAY BE AN EFFECTIVE TREATMENT FOR MAJOR DEPRESSIVE DISORDER (MDD). STUDIES EVALUATING THE "DOSING" OF YOGA TREATMENT AND EFFICACY FOR MDD ARE NEEDED. THE GOAL OF THIS STUDY WAS TO ASSESS THE EFFECTS OF AN INTERVENTION COMBINING IYENGAR YOGA AND COHERENT BREATHING IN PARTICIPANTS WITH MDD AND DETERMINE THE OPTIMAL INTERVENTION DOSE. METHODS: THIRTY-TWO PARTICIPANTS (18 TO 65 Y OF AGE) DIAGNOSED WITH MDD WERE RANDOMIZED TO A HIGH-DOSE GROUP (HDG) OR A LOW-DOSE GROUP (LDG) OF YOGA AND COHERENT BREATHING FOR 12 WEEKS. THE HDG (N=15) INVOLVED THREE 90-MINUTE YOGA CLASSES AND FOUR 30-MINUTE HOMEWORK SESSIONS PER WEEK. THE LDG (N=15) INVOLVED TWO 90-MINUTE YOGA CLASSES AND THREE 30-MINUTE HOMEWORK SESSIONS PER WEEK. PARTICIPANTS WERE EVALUATED AT BASELINE, WEEK 4, WEEK 8, AND WEEK 12 WITH THE FOLLOWING INSTRUMENTS: POSITIVITY SELF-TEST, SPIELBERGER STATE ANXIETY INVENTORY, PATIENT HEALTH QUESTIONNAIRE-9, PITTSBURGH SLEEP QUALITY INDEX, AND EXERCISE-INDUCED FEELING INVENTORY. DATA WERE ANALYZED USING INTENT-TO-TREAT METHODS. RESULTS: SIGNIFICANT IMPROVEMENTS IN ALL OUTCOME MEASURES WERE FOUND FOR BOTH GROUPS, WITH ACUTE AND CUMULATIVE BENEFITS. ALTHOUGH THE HDG SHOWED GREATER IMPROVEMENTS ON ALL SCALES, BETWEEN-GROUP DIFFERENCES DID NOT REACH SIGNIFICANCE, POSSIBLY DUE TO LACK OF POWER BECAUSE OF THE SMALL SAMPLE SIZE. CUMULATIVE YOGA MINUTES WERE CORRELATED WITH IMPROVEMENT IN OUTCOME MEASURES. LIMITATION: THIS DOSING STUDY DID NOT INCLUDE A NON-YOGA CONTROL. CONCLUSIONS: IMPROVEMENT IN PSYCHOLOGICAL SYMPTOMS CORRELATED WITH CUMULATIVE YOGA PRACTICE. BOTH INTERVENTIONS REDUCED SYMPTOMS OF DEPRESSION AND ANXIETY AND INCREASED FEELINGS OF POSITIVITY. THE TIME COMMITMENT FOR YOGA PRACTICE NEEDS TO BE WEIGHED AGAINST BENEFITS WHEN DESIGNING YOGA INTERVENTIONS.	2019	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
19 2854  45 YOGA- AND MEDITATION-BASED LIFESTYLE INTERVENTION INCREASES NEUROPLASTICITY AND REDUCES SEVERITY OF MAJOR DEPRESSIVE DISORDER: A RANDOMIZED CONTROLLED TRIAL. BACKGROUND: CURRENT INTERVENTIONS FOR MAJOR DEPRESSIVE DISORDER (MDD) ARE SUBOPTIMAL, AND ONLY ONE THIRD RESPOND TO THEM ON INITIAL TREATMENT. NEUROPLASTICITY THEORIES ARE THE BASIS FOR SEVERAL EMERGING TREATMENTS. EVIDENCE ON THE IMPACT OF YOGA, A WELL-KNOWN MIND-BODY INTERVENTION, ON NEUROPLASTICITY IN MDD IS LIMITED. OBJECTIVES: TO DETERMINE THE EFFECTS OF 12-WEEK YOGA- AND MEDITATION-BASED LIFESTYLE INTERVENTION (YMLI) ON DEPRESSION SEVERITY AND SYSTEMIC BIOMARKERS OF NEUROPLASTICITY IN ADULT MDD PATIENTS ON ROUTINE DRUG TREATMENT. METHODS: A TOTAL OF 58 MDD PATIENTS WERE RANDOMIZED INTO YOGA OR CONTROL GROUP. THE SEVERITY OF DEPRESSION WAS ASSESSED WITH BECK DEPRESSION INVENTORY-II SCALE (BDI-II). BLOOD SAMPLES WERE COLLECTED BEFORE AND AFTER INTERVENTION FOR THE MEASUREMENT OF THE BIOMARKERS THAT CHARACTERIZE NEUROPLASTICITY, INCLUDING MIND-BODY COMMUNICATIVE AND CELLULAR HEALTH BIOMARKERS. RESULTS: THERE WAS A SIGNIFICANT DECREASE [DIFFERENCE BETWEEN MEANS, (95% CI)] IN BDI-II SCORE [-5.83 (-7.27, -4.39), P < 0.001] AND SIGNIFICANT INCREASE IN BDNF (NG/ML) [5.48 (3.50, 7.46), P < 0.001] AFTER YMLI COMPARED TO CONTROL GROUP. YMLI SIGNIFICANTLY INCREASED DHEAS, SIRTUIN 1, AND TELOMERASE ACTIVITY LEVELS, AND DECREASED CORTISOL, AND IL-6 LEVELS, IN ADDITION TO DECREASING DNA DAMAGE AND BALANCING OXIDATIVE STRESS. MULTIPLE REGRESSION ANALYSES WERE USED TO ASSOCIATE NEUROPLASTICITY BIOMARKERS WITH DEPRESSION SEVERITY. A 'POST-INTERVENTION CHANGE IN BDNF' X 'GROUP' INTERACTION INDICATED THAT YOGA GROUP HAD MORE BDNF IN ASSOCIATION WITH LESS BDI-II SCORES RELATIVE TO CONTROLS. INCREASED SIRTUIN 1 AND TELOMERASE ACTIVITY AND DECREASED CORTISOL SIGNIFICANTLY PREDICTED THIS ASSOCIATION (ALL P < 0.05). CONCLUSION: THESE RESULTS SUGGEST THAT DECREASE IN DEPRESSION SEVERITY AFTER YMLI IN MDD IS ASSOCIATED WITH IMPROVED SYSTEMIC BIOMARKERS OF NEUROPLASTICITY. THUS YMLI CAN BE CONSIDERED AS A THERAPEUTIC INTERVENTION IN MDD MANAGEMENT.	2018	
                                                                                                                                                                                                                                                                                                                                                             
20 1423  36 IMPROVEMENT IN NEUROCOGNITIVE FUNCTIONS AND SERUM BRAIN-DERIVED NEUROTROPHIC FACTOR LEVELS IN PATIENTS WITH DEPRESSION TREATED WITH ANTIDEPRESSANTS AND YOGA. CONTEXT AND AIMS: IMPAIRMENT IN COGNITION IS WELL-KNOWN IN PATIENTS WITH MAJOR DEPRESSIVE DISORDER. THIS STUDY EXAMINED THE EFFECT OF YOGA THERAPY WITH OR WITHOUT ANTIDEPRESSANTS AND ANTIDEPRESSANTS ALONE ON CERTAIN NEUROPSYCHOLOGICAL FUNCTIONS IN PATIENTS WITH DEPRESSION. CORRELATION BETWEEN CHANGES IN NEUROPSYCHOLOGICAL TEST PERFORMANCE AND SERUM BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) LEVELS WAS ALSO EXPLORED. MATERIALS AND METHODS: ANTIDEPRESSANT-NAIVE/ANTIDEPRESSANT-FREE OUTPATIENTS WITH DEPRESSION RECEIVED ANTIDEPRESSANT MEDICATION ALONE (N = 23) OR YOGA THERAPY WITH (N = 26) OR WITHOUT (N = 16) ANTIDEPRESSANTS. DEPRESSION WAS ASSESSED USING THE HAMILTON DEPRESSION RATING SCALE. NEUROPSYCHOLOGICAL TESTS INCLUDED DIGIT-SPAN FORWARD AND BACKWARD, REY AUDITORY VERBAL LEARNING TEST, AND TRAIL MAKING TESTS (TMT-A AND B). THESE TESTS WERE ADMINISTERED BEFORE AND 3 MONTHS AFTER THE TREATMENT IN PATIENTS, AND ONCE IN HEALTHY COMPARISON SUBJECTS (N = 19). STATISTICAL ANALYSIS: BASELINE DIFFERENCES WERE ANALYZED USING INDEPENDENT SAMPLE T-TEST, CHI-SQUARE, AND ONE-WAY ANOVA. PAIRED T-TEST WAS USED TO ANALYZE THE CHANGE FROM BASELINE TO FOLLOW-UP. PEARSON'S CORRELATION WAS USED TO EXPLORE THE ASSOCIATION OF CHANGE BETWEEN 2 VARIABLES. RESULTS: PATIENTS HAD IMPAIRED PERFORMANCE ON MOST NEUROPSYCHOLOGICAL TESTS. AFTER 3 MONTHS, THERE WAS SIGNIFICANT IMPROVEMENT - PATIENTS' PERFORMANCE WAS COMPARABLE TO THAT OF HEALTHY CONTROLS ON MAJORITY OF THE TESTS. SIGNIFICANT INVERSE CORRELATION WAS OBSERVED BETWEEN INCREASE IN BDNF LEVELS AND IMPROVEMENT IN TMT "A" DURATION IN YOGA-ALONE GROUP (R = -0.647; P = 0.009). CONCLUSIONS: TO CONCLUDE THAT, YOGA THERAPY, ALONE OR IN COMBINATION WITH MEDICATIONS, IS ASSOCIATED WITH IMPROVED NEUROPSYCHOLOGICAL FUNCTIONS AND NEUROPLASTIC EFFECTS IN PATIENTS WITH DEPRESSION.	2018