1 683 183 EFFECT OF AN 8-WEEK YOGA-BASED LIFESTYLE INTERVENTION ON PSYCHO-NEURO-IMMUNE AXIS, DISEASE ACTIVITY, AND PERCEIVED QUALITY OF LIFE IN RHEUMATOID ARTHRITIS PATIENTS: A RANDOMIZED CONTROLLED TRIAL. VARIOUS EXTERNAL STRESSORS AND ENVIRONMENTAL CHALLENGES LEAD TO THE PROVOCATION OF THE IMMUNE SYSTEM IN AUTOIMMUNE DISEASES LIKE RHEUMATOID ARTHRITIS (RA). THE INAPPROPRIATE IMMUNE RESPONSE FURTHER TRIGGERS THE CASCADE OF INFLAMMATORY CHANGES RESULTING IN PRECIPITATION OF SYMPTOMS AND HAMPERS QUALITY OF LIFE (QOL). THE UNDERLYING PSYCHO-SOMATIC COMPONENT OF THE DISEASE REQUIRES A HOLISTIC APPROACH TO ITS TREATMENT DIMENSION RATHER THAN THE USE OF PHARMACOTHERAPY. THE APPLICABILITY OF MIND-BODY INTERVENTIONS HAS BECOME ESSENTIAL IN TODAY'S FAST-PACED LIFE. YOGA, A MIND-BODY TECHNIQUE, ALTERS THE MIND'S CAPACITY TO FACILITATE SYSTEMIC FUNCTIONING AT MULTIPLE ORGAN SYSTEM LEVELS. HENCE, WE CONDUCTED THIS STUDY TO EVALUATE THE IMPACT OF 8 WEEKS OF A YOGA-BASED LIFESTYLE INTERVENTION (YBLI) ON PSYCHO-NEURO-IMMUNE MARKERS, GENE EXPRESSION PATTERNS, AND QOL IN RA PATIENTS ON ROUTINE MEDICAL THERAPY. A TOTAL OF 66 PATIENTS WERE RANDOMIZED INTO TWO GROUPS: YOGA GROUP OR NON-YOGA GROUP AND WERE ASSESSED FOR A PANEL OF INFLAMMATORY CYTOKINES (IL-6, IL-17A, TNF-ALPHA, AND TGF-BETA), MIND-BODY COMMUNICATIVE MARKERS (BDNF, DHEAS, BETA-ENDORPHIN, AND SIRTUIN) AND TRANSCRIPT LEVELS OF VARIOUS GENES (IL-6, TNF-ALPHA, NFKB1, TGF-BETA, AND CTLA4). WE ASSESSED DISEASE ACTIVITY AND QOL USING THE DAS28-ESR AND WHOQOL-BREF QUESTIONNAIRE, RESPECTIVELY. YOGA GROUP OBSERVED SIGNIFICANT IMPROVEMENTS IN THE LEVELS OF MARKERS, WHICH INFLUENCED THE PSYCHO-NEURO-IMMUNE AXIS (P < 0.001) WITH AN ESTIMATED EFFECT SIZE FROM SMALL TO MEDIUM RANGE. IN THE YOGA GROUP, THERE WAS A SIGNIFICANT REDUCTION IN DAS28-ESR (P < 0.001) AND IMPROVEMENT SEEN IN THE PHYSICAL HEALTH, PSYCHOLOGICAL, SOCIAL RELATIONSHIPS DOMAINS (P < 0.001) OF QOL, EXCEPT ENVIRONMENTAL (P > 0.05). THE YOGA GROUP SHOWED DOWNREGULATION OF IL-6, TNF-ALPHA, AND CTLA4 AND UPREGULATION OF TGF-BETA. THESE RESULTS SUGGEST THAT A DECREASE IN DISEASE ACTIVITY AFTER YOGA PRACTICE IS ASSOCIATED WITH A SIGNIFICANT REDUCTION IN INFLAMMATORY CYTOKINES, THE ELEVATION OF MIND-BODY COMMUNICATIVE MARKERS, AND NORMALIZATION OF VARIOUS TRANSCRIPT LEVELS, WHICH IMPROVED QOL. THUS THE ADOPTION OF YBLI IMPROVES CLINICAL OUTCOME IN RA, AND DECREASES SYSTEMIC INFLAMMATION BY ITS BENEFICIAL EFFECTS ON PSYCHO-NEURO-IMMUNE AXIS AND NORMALIZATION OF DYSREGULATED TRANSCRIPTS. THUS YBLI MAY BE USED FOR RA PATIENTS AS AN ADJUNCTIVE THERAPY. 2020 2 1639 33 MODULATION OF IMMUNE RESPONSES IN STRESS BY YOGA. STRESS IS A CONSTANT FACTOR IN TODAY'S FASTPACED LIFE THAT CAN JEOPARDIZE OUR HEALTH IF LEFT UNCHECKED. IT IS ONLY IN THE LAST HALF CENTURY THAT THE ROLE OF STRESS IN EVERY AILMENT FROM THE COMMON COLD TO AIDS HAS BEEN EMPHASIZED, AND THE MECHANISMS INVOLVED IN THIS PROCESS HAVE BEEN STUDIED. STRESS INFLUENCES THE IMMUNE RESPONSE PRESUMABLY THROUGH THE ACTIVATION OF THE HYPOTHALAMIC-PITUITARY ADRENAL AXIS, HYPOTHALAMIC PITUITARY-GONADAL AXIS, AND THE SYMPATHETIC-ADRENAL-MEDULLARY SYSTEM. VARIOUS NEUROTRANSMITTERS, NEUROPEPTIDES, HORMONES, AND CYTOKINES MEDIATE THESE COMPLEX BIDIRECTIONAL INTERACTIONS BETWEEN THE CENTRAL NERVOUS SYSTEM (CNS) AND THE IMMUNE SYSTEM. THE EFFECTS OF STRESS ON THE IMMUNE RESPONSES RESULT IN ALTERATIONS IN THE NUMBER OF IMMUNE CELLS AND CYTOKINE DYSREGULATION. VARIOUS STRESS MANAGEMENT STRATEGIES SUCH AS MEDITATION, YOGA, HYPNOSIS, AND MUSCLE RELAXATION HAVE BEEN SHOWN TO REDUCE THE PSYCHOLOGICAL AND PHYSIOLOGICAL EFFECTS OF STRESS IN CANCERS AND HIV INFECTION. THIS REVIEW AIMS TO DISCUSS THE EFFECT OF STRESS ON THE IMMUNE SYSTEM AND EXAMINE HOW RELAXATION TECHNIQUES SUCH AS YOGA AND MEDITATION COULD REGULATE THE CYTOKINE LEVELS AND HENCE, THE IMMUNE RESPONSES DURING STRESS. 2008 3 19 34 "WE REALLY NEED THIS": TRAUMA-INFORMED YOGA FOR VETERAN WOMEN WITH A HISTORY OF MILITARY SEXUAL TRAUMA. OBJECTIVES: UP TO 70% OF WOMEN SERVICE MEMBERS IN THE UNITED STATES REPORT MILITARY SEXUAL TRAUMA (MST); MANY DEVELOP POST-TRAUMATIC STRESS DISORDER (PTSD) AND CO-OCCURRING DISORDERS. TRAUMA-INFORMED YOGA (TIY) IS SUGGESTED TO IMPROVE PSYCHIATRIC SYMPTOMS AND SHOWN FEASIBLE AND ACCEPTABLE IN EMERGING RESEARCH, YET NO WORK HAS EVALUATED TIY IN MST SURVIVORS. THE CURRENT QUALITY IMPROVEMENT PROJECT AIMED TO EXAMINE TIY'S FEASIBILITY, ACCEPTABILITY, AND PERCEIVED EFFECTS IN THE CONTEXT OF MST. DESIGN: COLLECTIVE CASE SERIES (N = 7). SETTING: NEW ENGLAND VET CENTER. INTERVENTIONS: EXTANT TIY PROGRAM (MINDFUL YOGA THERAPY) ADAPTED FOR VETERAN WOMEN WITH MST IN CONCURRENT PSYCHOTHERAPY. MAIN OUTCOME MEASURES: ATTRITION AND ATTENDANCE; QUALITATIVE EXIT INTERVIEW; VALIDATED SELF-REPORT MEASURE OF NEGATIVE AFFECT PRE/POST EACH YOGA CLASS, AND SYMPTOM SEVERITY ASSESSMENTS AND SURVEYS BEFORE (T1; TIME 1) AND AFTER THE YOGA PROGRAM (T2; TIME 2). RESULTS: FEASIBILITY WAS DEMONSTRATED AND WOMEN REPORTED TIY WAS ACCEPTABLE. IN QUALITATIVE INTERVIEWS, WOMEN REPORTED IMPROVED SYMPTOM SEVERITY, DIET, EXERCISE, ALCOHOL USE, SLEEP, AND PAIN; REDUCED MEDICATION USE; AND THEMES RELATED TO STRESS REDUCTION, MINDFULNESS, AND SELF-COMPASSION. REGARDING QUANTITATIVE CHANGE, RESULTS SUGGEST ACUTE REDUCTIONS IN NEGATIVE AFFECT FOLLOWING YOGA SESSIONS ACROSS PARTICIPANTS, AS WELL AS IMPROVED AFFECT DYSREGULATION, SHAME, AND MINDFULNESS T1 TO T2. CONCLUSIONS: TIY IS BOTH FEASIBLE AND ACCEPTABLE TO VETERAN WOMEN MST SURVIVORS IN ONE SPECIFIC VET CENTER, WITH PERCEIVED BEHAVIORAL HEALTH BENEFITS. RESULTS SUGGEST TIY MAY TARGET PSYCHOSOCIAL MECHANISMS IMPLICATED IN HEALTH BEHAVIOR CHANGE (STRESS REDUCTION, MINDFULNESS, AFFECT REGULATION, SHAME). FORMAL RESEARCH SHOULD BE CONDUCTED TO CONFIRM THESE QI PROJECT RESULTS. 2021 4 588 47 DETERMINING PSYCHONEUROIMMUNOLOGIC MARKERS OF YOGA AS AN INTERVENTION FOR PERSONS DIAGNOSED WITH PTSD: A SYSTEMATIC REVIEW. THERE IS A GROWING BODY OF RESEARCH ON YOGA AS A THERAPEUTIC INTERVENTION FOR PSYCHOLOGICAL SYMPTOMS OF POST-TRAUMATIC STRESS DISORDER (PTSD) ACCOMPANIED BY SPECULATIONS ON UNDERLYING PHYSIOLOGIC MECHANISMS. THE PURPOSE OF THIS SYSTEMATIC REVIEW IS TO IDENTIFY, QUALITATIVELY EVALUATE, AND SYNTHESIZE STUDIES OF YOGA AS AN INTERVENTION FOR PTSD THAT MEASURED PHYSIOLOGIC OUTCOMES IN ORDER TO GAIN INSIGHTS INTO POTENTIAL MECHANISMS. THE FOCUS IS ON STUDIES EVALUATING YOGA AS A THERAPEUTIC INTERVENTION FOR PTSD RATHER THAN FOR TRAUMA EXPOSURE, PTSD PREVENTION, OR SUBCLINICAL PTSD. MULTIPLE DATABASES WERE SEARCHED FOR PUBLICATIONS FROM THE PAST TWO DECADES USING TERMS DERIVED FROM THE QUESTION, "IN PEOPLE WITH PTSD, WHAT IS THE EFFECT OF YOGA ON OBJECTIVE OUTCOMES?" ELIGIBILITY CRITERIA INCLUDED YOGA-ONLY MODALITIES TESTED AS AN INTERVENTION FOR FORMALLY DIAGNOSED PTSD WITH AT LEAST ONE PHYSIOLOGIC OUTCOME. RESULTS OF THIS REVIEW CONFIRMED THAT, THOUGH MUCH OF THE PUBLISHED LITERATURE PROPOSES PHYSIOLOGICAL MECHANISMS UNDERLYING YOGA'S EFFECTS ON PTSD, VERY FEW STUDIES ( N = 3) HAVE ACTUALLY EVALUATED PHYSIOLOGICAL EVIDENCE. ADDITIONALLY, SEVERAL STUDIES HAD METHODOLOGICAL LIMITATIONS. IN LIGHT OF THE LIMITED DATA SUPPORTING YOGA'S BENEFICIAL EFFECTS ON AUTONOMIC NERVOUS SYSTEM DYSREGULATION, WE PRESENT A THEORETICAL MODEL OF THE PSYCHONEUROIMMUNOLOGIC PROCESSES ASSOCIATED WITH PTSD AND THE EFFECTS YOGA MAY HAVE ON THESE PROCESSES TO GUIDE FUTURE RESEARCH. GAPS IN THE LITERATURE REMAIN FOR MECHANISMS RELATED TO ACTIVATION OF THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS AND INFLAMMATION. ADDITIONAL RIGOROUS MECHANISTIC STUDIES ARE NEEDED TO GUIDE DEVELOPMENT OF EFFECTIVE YOGA INTERVENTIONS FOR PTSD TO AUGMENT EXISTING EVIDENCE-BASED PTSD TREATMENTS. 2018 5 156 37 A QUALITATIVE STUDY OF LOVEYOURBRAIN YOGA: A GROUP-BASED YOGA WITH PSYCHOEDUCATION INTERVENTION TO FACILITATE COMMUNITY INTEGRATION FOR PEOPLE WITH TRAUMATIC BRAIN INJURY AND THEIR CAREGIVERS. PURPOSE: TO EXPLORE PARTICIPANTS' EXPERIENCES IN A GROUP-BASED YOGA WITH PSYCHOEDUCATION INTERVENTION DESIGNED TO FACILITATE COMMUNITY INTEGRATION FOR PEOPLE WITH TRAUMATIC BRAIN INJURY AND THEIR CAREGIVERS.MATERIALS AND METHODS: WE CONDUCTED SEMI-STRUCTURED INTERVIEWS WITH 13 PEOPLE WITH TRAUMATIC BRAIN INJURY AND THREE CAREGIVERS WHO HAD COMPLETED LOVEYOURBRAIN YOGA, A 6-SESSION, MANUALIZED, GROUP-BASED YOGA INTERVENTION THAT INCORPORATES BREATHING EXERCISES, YOGA, MEDITATION, AND PSYCHOEDUCATION. INTERVIEWS WERE ANALYZED USING CONTENT ANALYSIS.RESULTS: WE IDENTIFIED SEVEN THEMES: EASE OF PARTICIPATION, BELONGING, SUSTAINING COMMUNITY CONNECTION, PHYSICAL HEALTH, SELF-REGULATION, SELF-EFFICACY, AND RESILIENCE. ALL PARTICIPANTS VALUED THE COMMUNITY-BASED YOGA STUDIO ENVIRONMENT AND MULTIFACETED STRUCTURE OF THE PROGRAM. PARTICIPANTS REPORTED IMPROVEMENTS IN STRENGTH, BALANCE, FLEXIBILITY, AND ATTENTION CONTROL, AND A GREATER SENSE OF BELONGING, COMMUNITY CONNECTION, AND ABILITY TO MOVE FORWARD WITH THEIR LIVES. PARTICIPANTS REPORTED ONGOING USE OF TOOLS (E.G., BREATHING EXERCISES) TO COPE WITH NEGATIVE EMOTIONS AND STRESS. ABOUT HALF OF PARTICIPANTS SUSTAINED RELATIONSHIPS BUILT DURING LOVEYOURBRAIN YOGA AND FELT MORE CAPABLE OF ACCESSING OTHER ACTIVITIES IN THEIR COMMUNITY.CONCLUSIONS: LOVEYOURBRAIN YOGA SUCCESSFULLY PROMOTED COMMUNITY INTEGRATION FOR PEOPLE WITH TRAUMATIC BRAIN INJURY. IT ALSO FACILITATED DIVERSE AND MEANINGFUL PHYSICAL, PSYCHOLOGICAL, AND SOCIAL HEALTH BENEFITS, WHICH SUGGEST THAT IT MAY BE AN EFFECTIVE MODE OF COMMUNITY-BASED REHABILITATION.IMPLICATIONS FOR REHABILITATIONTRAUMATIC BRAIN INJURY SURVIVORS OFTEN STRUGGLE TO PARTICIPATE IN THEIR COMMUNITY, THE ULTIMATE GOAL OF REHABILITATIONYOGA IS A HOLISTIC THERAPY WITH MANY BENEFITS, YET IS NOT ACCESSIBLE TO THE TRAUMATIC BRAIN INJURY POPULATION AT THE COMMUNITY LEVELPARTICIPANTS IN A COMMUNITY-BASED YOGA WITH PSYCHOEDUCATION INTERVENTION IN SIX STATES EXPERIENCED DIVERSE AND MEANINGFUL PHYSICAL, PSYCHOLOGICAL, AND SOCIAL HEALTH BENEFITSGROUP-BASED YOGA WITH PSYCHOEDUCATION MAY BE AN EFFECTIVE MODE OF COMMUNITY INTEGRATION AND COMMUNITY-BASED REHABILITATION FOR TRAUMATIC BRAIN INJURY SURVIVORS. 2020 6 333 33 APPLICATION OF YOGA IN RESIDENTIAL TREATMENT OF TRAUMATIZED YOUTH. BACKGROUND: THE TRAUMA CENTER AT JUSTICE RESOURCE INSTITUTE HAS ADAPTED A FORM OF HATHA YOGA INTO A TRAUMA-SENSITIVE ADJUNCTIVE COMPONENT OF INTERVENTION FOR USE WITH COMPLEXLY TRAUMATIZED INDIVIDUALS EXHIBITING CHRONIC AFFECTIVE AND SOMATIC DYSREGULATION AND ASSOCIATED BEHAVIORAL, FUNCTIONING, AND HEALTH COMPLAINTS. OBJECTIVES: THIS ARTICLE EXPLORES THE USE OF YOGA WITH TRAUMATIZED YOUTH (AGED 12-21 YEARS) IN RESIDENTIAL TREATMENT. DESIGN: A REVIEW OF THE LITERATURE ON THE SOMATIC IMPACT OF TRAUMA EXPOSURE PROVIDES A RATIONALE FOR THE USE OF YOGA WITH THIS POPULATION AND HIGHLIGHTS AN EMERGING EVIDENCE BASE IN SUPPORT OF THIS PRACTICE. CASE VIGNETTES ILLUSTRATE THE INTEGRATION OF STRUCTURED, GENTLE YOGA PRACTICES INTO RESIDENTIAL PROGRAMMING FOR YOUTH WITH SEVERE EMOTIONAL AND BEHAVIORAL PROBLEMS. RESULTS: ANECDOTAL DATA AND CLINICAL OBSERVATION UNDERSCORE THE PROMISE OF YOGA AS A VIABLE APPROACH TO BUILD SELF-REGULATORY CAPACITY OF TRAUMATIZED YOUTH. CONCLUSIONS: FUTURE DIRECTIONS IN THE DEVELOPMENT AND EVALUATION OF TRAUMA-INFORMED YOGA PRACTICES FOR YOUTH ARE DISCUSSED. 2011 7 226 38 A SYSTEMATIC REVIEW OF RANDOMISED CONTROL TRIALS ON THE EFFECTS OF YOGA ON STRESS MEASURES AND MOOD. STRESS RELATED DISORDERS SUCH AS DEPRESSION AND ANXIETY ARE LEADING SOURCES OF DISABILITY WORLDWIDE, AND CURRENT TREATMENT METHODS SUCH AS CONVENTIONAL ANTIDEPRESSANT MEDICATIONS ARE NOT BENEFICIAL FOR ALL INDIVIDUALS. THERE IS EVIDENCE THAT YOGA HAS MOOD-ENHANCING PROPERTIES POSSIBLY RELATED TO ITS INHIBITORY EFFECTS ON PHYSIOLOGICAL STRESS AND INFLAMMATION, WHICH ARE FREQUENTLY ASSOCIATED WITH AFFECTIVE DISORDERS. HOWEVER THE BIOLOGICAL MECHANISMS VIA WHICH YOGA EXERTS ITS THERAPEUTIC MOOD-MODULATING EFFECTS ARE LARGELY UNKNOWN. THIS SYSTEMATIC REVIEW INVESTIGATES THE EFFECTS OF YOGA ON SYMPATHETIC NERVOUS SYSTEM AND HYPOTHALAMIC PITUITARY ADRENAL AXIS REGULATION MEASURES. IT FOCUSES ON STUDIES COLLECTING PHYSIOLOGICAL PARAMETERS SUCH AS BLOOD PRESSURE, HEART RATE, CORTISOL, PERIPHERAL CYTOKINE EXPRESSION AND/OR STRUCTURAL AND FUNCTIONAL BRAIN MEASURES IN REGIONS INVOLVED IN STRESS AND MOOD REGULATION. OVERALL THE 25 RANDOMISED CONTROL STUDIES DISCUSSED PROVIDE PRELIMINARY EVIDENCE TO SUGGEST THAT YOGA PRACTICE LEADS TO BETTER REGULATION OF THE SYMPATHETIC NERVOUS SYSTEM AND HYPOTHALAMIC-PITUITARY-ADRENAL SYSTEM, AS WELL AS A DECREASE IN DEPRESSIVE AND ANXIOUS SYMPTOMS IN A RANGE OF POPULATIONS. FURTHER RESEARCH IS WARRANTED TO CONFIRM THESE PRELIMINARY FINDINGS AND FACILITATE IMPLEMENTATION IN CLINICAL SETTINGS. 2015 8 2538 44 YOGA FOR ADULT WOMEN WITH CHRONIC PTSD: A LONG-TERM FOLLOW-UP STUDY. INTRODUCTION: YOGA-THE INTEGRATIVE PRACTICE OF PHYSICAL POSTURES AND MOVEMENT, BREATH EXERCISES, AND MINDFULNESS-MAY SERVE AS A USEFUL ADJUNCTIVE COMPONENT OF TRAUMA-FOCUSED TREATMENT TO BUILD SKILLS IN TOLERATING AND MODULATING PHYSIOLOGIC AND AFFECTIVE STATES THAT HAVE BECOME DYSREGULATED BY TRAUMA EXPOSURE. A PREVIOUS RANDOMIZED CONTROLLED STUDY WAS CARRIED OUT AMONG 60 WOMEN WITH CHRONIC, TREATMENT-RESISTANT POST-TRAUMATIC STRESS DISORDER (PTSD) AND ASSOCIATED MENTAL HEALTH PROBLEMS STEMMING FROM PROLONGED OR MULTIPLE TRAUMA EXPOSURES. AFTER 10 SESSIONS OF YOGA, PARTICIPANTS EXHIBITED STATISTICALLY SIGNIFICANT DECREASES IN PTSD SYMPTOM SEVERITY AND GREATER LIKELIHOOD OF LOSS OF PTSD DIAGNOSIS, SIGNIFICANT DECREASES IN ENGAGEMENT IN NEGATIVE TENSION REDUCTION ACTIVITIES (E.G., SELF-INJURY), AND GREATER REDUCTIONS IN DISSOCIATIVE AND DEPRESSIVE SYMPTOMS WHEN COMPARED WITH THE CONTROL (A SEMINAR IN WOMEN'S HEALTH). THE CURRENT STUDY IS A LONG-TERM FOLLOW-UP ASSESSMENT OF PARTICIPANTS WHO COMPLETED THIS RANDOMIZED CONTROLLED TRIAL. METHODS: PARTICIPANTS FROM THE RANDOMIZED CONTROLLED TRIAL WERE INVITED TO PARTICIPATE IN LONG-TERM FOLLOW-UP ASSESSMENTS APPROXIMATELY 1.5 YEARS AFTER STUDY COMPLETION TO ASSESS WHETHER THE INITIAL INTERVENTION AND/OR YOGA PRACTICE AFTER TREATMENT WAS ASSOCIATED WITH ADDITIONAL CHANGES. FORTY-NINE WOMEN COMPLETED THE LONG-TERM FOLLOW-UP INTERVIEWS. HIERARCHICAL REGRESSION ANALYSIS WAS USED TO EXAMINE WHETHER TREATMENT GROUP STATUS IN THE ORIGINAL STUDY AND FREQUENCY OF YOGA PRACTICE AFTER THE STUDY PREDICTED GREATER CHANGES IN SYMPTOMS AND PTSD DIAGNOSIS. RESULTS: GROUP ASSIGNMENT IN THE ORIGINAL RANDOMIZED STUDY WAS NOT A SIGNIFICANT PREDICTOR OF LONGER-TERM OUTCOMES. HOWEVER, FREQUENCY OF CONTINUING YOGA PRACTICE SIGNIFICANTLY PREDICTED GREATER DECREASES IN PTSD SYMPTOM SEVERITY AND DEPRESSION SYMPTOM SEVERITY, AS WELL AS A GREATER LIKELIHOOD OF A LOSS OF PTSD DIAGNOSIS. CONCLUSIONS: YOGA APPEARS TO BE A USEFUL TREATMENT MODALITY; THE GREATEST LONG-TERM BENEFITS ARE DERIVED FROM MORE FREQUENT YOGA PRACTICE. 2016 9 1089 35 EFFECTS OF YOGA ON THE AUTONOMIC NERVOUS SYSTEM, GAMMA-AMINOBUTYRIC-ACID, AND ALLOSTASIS IN EPILEPSY, DEPRESSION, AND POST-TRAUMATIC STRESS DISORDER. A THEORY IS PROPOSED TO EXPLAIN THE BENEFITS OF YOGA PRACTICES IN DIVERSE, FREQUENTLY COMORBID MEDICAL CONDITIONS BASED ON THE CONCEPT THAT YOGA PRACTICES REDUCE ALLOSTATIC LOAD IN STRESS RESPONSE SYSTEMS SUCH THAT OPTIMAL HOMEOSTASIS IS RESTORED. IT IS HYPOTHESIZED THAT STRESS INDUCES (1) IMBALANCE OF THE AUTONOMIC NERVOUS SYSTEM (ANS) WITH DECREASED PARASYMPATHETIC NERVOUS SYSTEM (PNS) AND INCREASED SYMPATHETIC NERVOUS SYSTEM (SNS) ACTIVITY, (2) UNDERACTIVITY OF THE GAMMA AMINO-BUTYRIC ACID (GABA) SYSTEM, THE PRIMARY INHIBITORY NEUROTRANSMITTER SYSTEM, AND (3) INCREASED ALLOSTATIC LOAD. IT IS FURTHER HYPOTHESIZED THAT YOGA-BASED PRACTICES (4) CORRECT UNDERACTIVITY OF THE PNS AND GABA SYSTEMS IN PART THROUGH STIMULATION OF THE VAGUS NERVES, THE MAIN PERIPHERAL PATHWAY OF THE PNS, AND (5) REDUCE ALLOSTATIC LOAD. DEPRESSION, EPILEPSY, POST TRAUMATIC STRESS DISORDER (PTSD), AND CHRONIC PAIN EXEMPLIFY MEDICAL CONDITIONS THAT ARE EXACERBATED BY STRESS, HAVE LOW HEART RATE VARIABILITY (HRV) AND LOW GABAERGIC ACTIVITY, RESPOND TO PHARMACOLOGIC AGENTS THAT INCREASE ACTIVITY OF THE GABA SYSTEM, AND SHOW SYMPTOM IMPROVEMENT IN RESPONSE TO YOGA-BASED INTERVENTIONS. THE OBSERVATION THAT TREATMENT RESISTANT CASES OF EPILEPSY AND DEPRESSION RESPOND TO VAGAL NERVE STIMULATION CORROBORATES THE NEED TO CORRECT PNS UNDERACTIVITY AS PART OF A SUCCESSFUL TREATMENT PLAN IN SOME CASES. ACCORDING TO THE PROPOSED THEORY, THE DECREASED PNS AND GABAERGIC ACTIVITY THAT UNDERLIES STRESS-RELATED DISORDERS CAN BE CORRECTED BY YOGA PRACTICES RESULTING IN AMELIORATION OF DISEASE SYMPTOMS. THIS HAS FAR-REACHING IMPLICATIONS FOR THE INTEGRATION OF YOGA-BASED PRACTICES IN THE TREATMENT OF A BROAD ARRAY OF DISORDERS EXACERBATED BY STRESS. 2012 10 2312 25 TRAUMA SENSITIVE YOGA AS A COMPLEMENTARY TREATMENT FOR POSTTRAUMATIC STRESS DISORDER: A QUALITATIVE DESCRIPTIVE ANALYSIS. RESEARCH ON POSTTRAUMATIC STRESS DISORDER AND CHRONIC CHILDHOOD ABUSE HAS REVEALED THAT TRADITIONAL TRAUMA TREATMENTS OFTEN FAIL TO FULLY ADDRESS THE COMPLICATED SYMPTOM PRESENTATION, INCLUDING THE SOMATIC COMPLAINTS, LOSS OF AWARENESS OF ONE'S EMOTIONAL AND PHYSICAL BEING IN THE PRESENT MOMENT, AND OVERALL LACK OF INTEGRATION BETWEEN THE SELF AND THE BODY. THE MINDFULNESS-BASED INTERVENTION OF HATHA YOGA SHOWS PROMISE AS A COMPLEMENTARY TREATMENT, AND FOCUSES ON PERSONAL GROWTH IN ADDITION TO SYMPTOM REDUCTION. THIS QUALITATIVE STUDY EXPLORED THE EXPERIENCES OF THIRTY-ONE ADULT WOMEN WITH PTSD RELATED TO CHRONIC CHILDHOOD TRAUMA WHO PARTICIPATED IN A 10-WEEK TRAUMA SENSITIVE YOGA CLASS, SPECIFICALLY EXAMINING PERCEIVED CHANGES IN SYMPTOMS AND PERSONAL GROWTH. FIVE THEMES WERE IDENTIFIED THAT REFLECT PARTICIPANTS' FEELINGS OF GRATITUDE AND COMPASSION, RELATEDNESS, ACCEPTANCE, CENTEREDNESS, AND EMPOWERMENT. RESULTS AND IMPLICATIONS FOR RESEARCH AND CLINICAL WORK ARE PRESENTED. 2017 11 2412 47 YOGA AND ITS IMPACT ON CHRONIC INFLAMMATORY AUTOIMMUNE ARTHRITIS. RHEUMATOID ARTHRITIS (RA) IS ONE OF THE MOST COMMON CHRONIC INFLAMMATORY AUTOIMMUNE DISEASES, WHICH ADVERSELY AFFECTS THE QUALITY OF LIFE. RA IS A DISEASE OF UNKNOWN ETIOLOGY, HOWEVER, BOTH GENETIC AND ENVIRONMENTAL FACTORS APPEAR TO CONTRIBUTE TO THE SUSCEPTIBILITY TO THIS DISEASE. THE SEVERITY AND PROGRESSION OF THE DISEASE ARE ATTRIBUTABLE TO THE RELEASE OF A HOST OF INFLAMMATORY CYTOKINES, CYTOTOXIC AND IMMUNE REGULATORY FACTORS. THE TREATMENTS OF RA ARE PRIMARILY LIMITED TO SYMPTOMATIC ALLEVIATION OF PAIN OR OTHER SYMPTOMS OR TO THE USE OF CYTOTOXIC DRUG TREATMENT IN SEVERE FORMS OF THE DISEASE WHICH IS COMMONLY ASSOCIATED WITH SIGNIFICANT SIDE EFFECTS. DESPITE LACK OF A CURE, THE DISEASE MAY BE CONTROLLED BY MIND-BODY INTERVENTIONS. HOLISTIC TREATMENTS SUCH AS YOGA SIGNIFICANTLY IMPROVE AND REDUCE THE PSYCHO-SOMATIC SYMPTOMS, PAIN PERCEPTION, DISABILITY QUOTIENT, JOINT FLEXIBILITY, RANGE OF MOTION, POSTURE, MUSCLE STRENGTH, COORDINATION, AND DISEASE ACTIVITY. HERE, WE DISCUSS THE FEATURES OF RA AND ADDRESS HOW YOGA CAN BE USED AS A THERAPEUTIC REGIMEN TO IMPROVE THE QUALITY OF LIFE OF PATIENTS WITH RA. 2021 12 761 37 EFFECT OF SUDARSHAN KRIYA YOGA (SKY) ON DAYTIME AND SITUATIONAL SLEEP PROPENSITY IN NOVICE PRACTITIONERS: A PROSPECTIVE COHORT STUDY. OBJECTIVES: HECTIC, LATE-NIGHT LIFESTYLE HAS REDUCED 90 MIN SLEEP IN 20% ADULTS RESULTING IN INSOMNIA AND EXCESSIVE DAYTIME SLEEPINESS (EDS). WE ASSESS THE SCOPE OF SUDARSHAN KRIYA YOGA (SKY), A 4-COMPONENT, BREATHING PROCESS IN REDUCING EDS, GENERALLY AND SITUATIONALLY. METHODS: THIS IS A PROSPECTIVE, CONTROLLED STUDY INVOLVING RANDOMIZED SUBJECTS WITHOUT ANY SLEEP-WAKE CYCLE ANOMALIES AND PRIOR EXPERIENCE IN SKY. SUBJECTS (N=52) PERFORMED 30 MIN OF SKY FOR 6 DAYS/WEEK FOR 8 WEEKS, WHILE CONTROLS (N=53) PERFORMED SITTING ACTIVITY AND SURYANAMASKAR FOR 4-WEEKS EACH. EPWORTH SLEEPINESS SCALE (ESS) WAS USED TO MEASURE EDS AT 0, 4, AND 8 WEEKS. RESULTS: SKY GROUP SHOWED SIGNIFICANT ESS SCORE IMPROVEMENTS BETWEEN 0-4 WEEKS AND 4-8 WEEKS OF 1.22 (P=0.0001) AND 1.66 (P=0.001) RESPECTIVELY. CONTROLS HOWEVER FAILED TO IMPROVE WITH SCORE DIFFERENCES OF 0.02 (P=0.892) AND 0.02 (P=0.8212) RESPECTIVELY. SKY GROUP SHOWED SIGNIFICANT ESS SCORE IMPROVEMENT OVER CONTROLS AT 4-WEEKS (DIFFERENCE=1.74; P=0.013) AND 8-WEEKS (DIFFERENCE EIGHT; P=0.0001). IMPROVEMENT WAS MOST FOR OBESE PEOPLE AND THOSE SITTING IN A HALTED CAR. CONCLUSIONS: IMPROVEMENT IN SUBJECTS' NIGHTTIME SLEEP AND DAYTIME WAKEFULNESS IN SKY PRACTITIONERS CAN BE ATTRIBUTED TO POLYVAGAL THEORY. INCREASED HEART RATE VARIABILITY (HRV) ALTERATIONS AND SYMPATHETIC HYPERAROUSAL IN CHRONIC INSOMNIA; AND CHOLINERGIC AND GABAERGIC DYSREGULATION IN ANXIETY DISORDERS ARE COUNTERED BY REGULATED VAGAL NERVE STIMULATION POST SKY. OUR STUDY ESTABLISHES EFFECTIVITY OF SKY IN REDUCING EDS (TOTAL AND SITUATIONAL), PROVIDES A CLINICAL CORRELATION FOR PRIOR POLYSOMNOGRAPHIC EVIDENCE AND PAVES WAY FOR LARGER TRIALS DIRECTED TOWARDS SKY PRESCRIPTIONS FOR INSOMNIA. 2020 13 2608 19 YOGA FOR PSYCHIATRIC DISORDERS: FROM FAD TO EVIDENCE-BASED INTERVENTION? THERE IS GROWING EVIDENCE FOR YOGA'S NEUROBIOLOGICAL EFFECTS IN PEOPLE WITH PSYCHIATRIC DISORDERS. POSTULATED MECHANISMS OF ACTION INCLUDE: (A) MODULATION OF THE HYPOTHALAMIC-PITUITARY-ADRENAL (HPA) AXIS; (B) ENHANCEMENT OF GABAERGIC NEUROTRANSMISSION; (C) AUTONOMIC MODULATION; AND (D) NEUROENDOCRINOLOGICAL EFFECTS. YOGA AS A THERAPEUTIC INTERVENTION IN PSYCHIATRIC DISORDERS APPEARS PROMISING AND MERITS FURTHER ATTENTION IN CLINICAL PRACTICE AND RESEARCH. 2020 14 743 44 EFFECT OF RESTORATIVE YOGA VS. STRETCHING ON DIURNAL CORTISOL DYNAMICS AND PSYCHOSOCIAL OUTCOMES IN INDIVIDUALS WITH THE METABOLIC SYNDROME: THE PRYSMS RANDOMIZED CONTROLLED TRIAL. PURPOSE: CHRONIC STIMULATION AND DYSREGULATION OF THE NEUROENDOCRINE SYSTEM BY STRESS MAY CAUSE METABOLIC ABNORMALITIES. WE ESTIMATED HOW MUCH CORTISOL AND PSYCHOSOCIAL OUTCOMES IMPROVED WITH A RESTORATIVE YOGA (RELAXATION) VERSUS A LOW IMPACT STRETCHING INTERVENTION FOR INDIVIDUALS WITH THE METABOLIC SYNDROME. METHODS: WE CONDUCTED A 1-YEAR MULTI-CENTER RANDOMIZED CONTROLLED TRIAL (6-MONTH INTERVENTION AND 6-MONTH MAINTENANCE PHASE) OF RESTORATIVE YOGA VS. STRETCHING. PARTICIPANTS COMPLETED SURVEYS TO ASSESS DEPRESSION, SOCIAL SUPPORT, POSITIVE AFFECT, AND STRESS AT BASELINE, 6 MONTHS AND 12 MONTHS. FOR EACH ASSESSMENT, WE COLLECTED SALIVA AT FOUR POINTS DAILY FOR THREE DAYS AND COLLECTED RESPONSE TO DEXAMETHASONE ON THE FOURTH DAY FOR ANALYSIS OF DIURNAL CORTISOL DYNAMICS. WE ANALYZED OUR DATA USING MULTIVARIATE REGRESSION MODELS, CONTROLLING FOR STUDY SITE, MEDICATIONS (ANTIDEPRESSANTS, HORMONE THERAPY), BODY MASS INDEX, AND BASELINE CORTISOL VALUES. RESULTS: PSYCHOSOCIAL OUTCOME MEASURES WERE AVAILABLE FOR 171 STUDY PARTICIPANTS AT BASELINE, 140 AT 6 MONTHS, AND 132 AT 1 YEAR. COMPLETE CORTISOL DATA WERE AVAILABLE FOR 136 OF 171 STUDY PARTICIPANTS (72 IN RESTORATIVE YOGA AND 64 IN STRETCHING) AND WERE ONLY AVAILABLE AT BASELINE AND 6 MONTHS. AT 6 MONTHS, THE STRETCHING GROUP HAD DECREASED CORTISOL AT WAKING AND BEDTIME COMPARED TO THE RESTORATIVE YOGA GROUP. THE PATTERN OF CHANGES IN STRESS MIRRORED THIS IMPROVEMENT, WITH THE STRETCHING GROUP SHOWING REDUCTIONS IN CHRONIC STRESS SEVERITY AND PERSEVERATIVE THOUGHTS ABOUT THEIR STRESS. PERCEIVED STRESS DECREASED BY 1.5 POINTS (-0.4; 3.3, P=0.11) AT 6 MONTHS, AND BY 2.0 POINTS (0.1; 3.9, P=0.04) AT 1 YEAR IN THE STRETCHING COMPARED TO RESTORATIVE YOGA GROUPS. POST HOC ANALYSES SUGGEST THAT IN THE STRETCHING GROUP ONLY, PERCEIVED INCREASES IN SOCIAL SUPPORT (PARTICULARLY FEELINGS OF BELONGING), BUT NOT CHANGES IN STRESS WERE RELATED TO IMPROVED CORTISOL DYNAMICS. CONCLUSIONS: WE FOUND SIGNIFICANT DECREASES IN SALIVARY CORTISOL, CHRONIC STRESS SEVERITY, AND STRESS PERCEPTION IN THE STRETCHING GROUP COMPARED TO THE RESTORATIVE YOGA GROUP. GROUP SUPPORT DURING THE INTERACTIVE STRETCH CLASSES MAY HAVE CONTRIBUTED TO THESE CHANGES. 2014 15 421 31 BRIDGING BODY AND MIND: CONSIDERATIONS FOR TRAUMA-INFORMED YOGA. INDIVIDUALS WHO SUFFER FROM TRAUMA-RELATED SYMPTOMS ARE A UNIQUE POPULATION THAT COULD BENEFIT FROM THE MIND-BODY PRACTICE OF YOGA-OR HAVE THEIR SYMPTOMS REACTIVATED BY IT, DEPENDING ON THE TYPE OF YOGA. TRAUMA-INFORMED YOGA (TIY), THAT IS, YOGA ADAPTED TO THE UNIQUE NEEDS OF INDIVIDUALS WORKING TO OVERCOME TRAUMA, MAY AMELIORATE SYMPTOMS BY CREATING A SAFE, TAILORED PRACTICE FOR STUDENTS TO LEARN HOW TO RESPOND, RATHER THAN REACT, TO SYMPTOMS AND CIRCUMSTANCES. YOGA NOT THUS ADAPTED, ON THE OTHER HAND, MAY INCREASE REACTIVITY AND ACTIVATE SYMPTOMS SUCH AS HYPERAROUSAL OR DISSOCIATION. THIS ARTICLE REPORTS ON EXPERT INPUT ABOUT ADAPTING YOGA FOR INDIVIDUALS WITH TRAUMA, WITH SPECIAL CONSIDERATIONS FOR MILITARY POPULATIONS. ELEVEN EXPERTS, RECRUITED BASED ON LITERATURE REVIEW AND REFERRALS, WERE INTERVIEWED IN PERSON OR VIA TELEPHONE AND ASKED SEVEN QUESTIONS ABOUT TRAUMA-INFORMED YOGA. VERBATIM TRANSCRIPTS WERE SUBJECTED TO OPEN-CODING THEMATIC ANALYSIS AND A PRIORI THEMES. FINDINGS REVEALED THAT TIY NEEDS TO EMPHASIZE BENEFICIAL PRACTICES (E.G., DIAPHRAGMATIC BREATH AND RESTORATIVE POSTURES), CONSIDER CONTRAINDICATIONS (E.G., AVOIDING SEQUENCES THAT OVERLY ENGAGE THE SYMPATHETIC NERVOUS SYSTEM), ADAPT TO LIMITATIONS AND CHALLENGES FOR TEACHING IN UNCONVENTIONAL SETTINGS (E.G., PRISONS, VA HOSPITALS), AND PROVIDE SPECIALIZED TRAINING AND PREPARATION (E.G., SPECIALIZED TIY CERTIFICATIONS, SELF-CARE OF INSTRUCTORS/THERAPISTS, ADAPTIONS FOR STUDENT NEEDS). TIY FOR VETERANS MUST ADDITIONALLY CONSIDER GENDER- AND CULTURE-RELATED BARRIERS, DIFFERING RELATIONSHIPS TO PAIN AND INJURY, AND MEDICATION AS A BARRIER TO PRACTICE. 2018 16 2403 33 YOGA AND EMOTION REGULATION IN HIGH SCHOOL STUDENTS: A RANDOMIZED CONTROLLED TRIAL. MIDDLE ADOLESCENTS (15-17 YEARS OLD) ARE PRONE TO INCREASED RISK TAKING AND EMOTIONAL INSTABILITY. EMOTION DYSREGULATION CONTRIBUTES TO A VARIETY OF PSYCHOSOCIAL DIFFICULTIES IN THIS POPULATION. A DISCIPLINE SUCH AS YOGA OFFERED DURING SCHOOL MAY INCREASE EMOTION REGULATION, BUT RESEARCH IN THIS AREA IS LACKING. THIS STUDY WAS DESIGNED TO EVALUATE THE IMPACT OF A YOGA INTERVENTION ON THE EMOTION REGULATION OF HIGH SCHOOL STUDENTS AS COMPARED TO PHYSICAL EDUCATION (PE). IN ADDITION, THE POTENTIAL MEDIATING EFFECTS OF MINDFUL ATTENTION, SELF-COMPASSION, AND BODY AWARENESS ON THE RELATIONSHIP BETWEEN YOGA AND EMOTION REGULATION WERE EXAMINED. HIGH SCHOOL STUDENTS WERE RANDOMIZED TO PARTICIPATE IN A 16-WEEK YOGA INTERVENTION (N = 19) OR REGULAR PE (N = 18). PRE-POST DATA ANALYSES REVEALED THAT EMOTION REGULATION INCREASED SIGNIFICANTLY IN THE YOGA GROUP AS COMPARED TO THE PE GROUP (F (1,32) = 7.50, P = .01, AND ETA(2) = .19). NO SIGNIFICANT RELATIONSHIP WAS DISCOVERED BETWEEN THE CHANGES IN EMOTION REGULATION AND THE PROPOSED MEDIATING VARIABLES. PRELIMINARY RESULTS SUGGEST THAT YOGA INCREASES EMOTION REGULATION CAPACITIES OF MIDDLE ADOLESCENTS AND PROVIDES BENEFITS BEYOND THAT OF PE ALONE. 2015 17 1575 36 MANAGING MENTAL HEALTH DISORDERS RESULTING FROM TRAUMA THROUGH YOGA: A REVIEW. THERE ARE MANY AND VARIED TYPES OF TRAUMA. THE EXTENT TO WHICH TRAUMA INFLUENCES THE MENTAL HEALTH OF AN INDIVIDUAL DEPENDS ON THE NATURE OF TRAUMA, AS WELL AS ON THE INDIVIDUAL'S COPING CAPABILITIES. OFTEN TRAUMA IS FOLLOWED BY DEPRESSION, ANXIETY, AND PTSD. AS THE PHARMACOLOGICAL REMEDIES FOR THESE CONDITIONS OFTEN HAVE UNDESIRABLE SIDE-EFFECTS, NONPHARMACOLOGICAL REMEDIES ARE THOUGHT OF AS A POSSIBLE ADD-ON TREATMENT. YOGA IS ONE SUCH MIND-BODY INTERVENTION. THIS PAPER COVERS ELEVEN STUDIES INDEXED IN PUBMED, IN WHICH MENTAL HEALTH DISORDERS RESULTING FROM TRAUMA WERE MANAGED THROUGH YOGA INCLUDING MEDITATION. THE AIM WAS TO EVALUATE THE USE OF YOGA IN MANAGING TRAUMA-RELATED DEPRESSION, ANXIETY, PTSD AND PHYSIOLOGICAL STRESS FOLLOWING EXPOSURE TO NATURAL CALAMITIES, WAR, INTERPERSONAL VIOLENCE, AND INCARCERATION IN A CORRECTIONAL FACILITY. AN ATTEMPT HAS ALSO BEEN MADE TO EXPLORE POSSIBLE MECHANISMS UNDERLYING BENEFITS SEEN. AS MOST OF THESE STUDIES WERE NOT DONE ON PERSONS EXPOSED TO TRAUMA THAT HAD PRACTICED YOGA, THIS IS A DEFINITE AREA FOR FURTHER RESEARCH. 2012 18 1640 44 MOLECULAR SIGNATURE OF THE IMMUNE RESPONSE TO YOGA THERAPY IN STRESS-RELATED CHRONIC DISEASE CONDITIONS: AN INSIGHT. THE WORLD HEALTH ORGANIZATION DEFINES HEALTH AS COMPLETE WELL-BEING IN TERMS OF PHYSICAL, MENTAL AND SOCIAL, AND NOT MERELY THE ABSENCE OF DISEASE. TO ATTAIN THIS, INDIVIDUAL SHOULD ADAPT AND SELF-MANGE THE SOCIAL, PHYSICAL AND EMOTIONAL CHALLENGES OF LIFE. EXPOSURE TO CHRONIC STRESS DUE TO URBANIZATION, WORK STRESS, NUCLEAR FAMILY, POLLUTION, UNHEALTHY FOOD HABITS, LIFESTYLE, ACCIDENTAL DEATH IN THE FAMILY, AND NATURAL CALAMITIES ARE THE TRIGGERING FACTORS, LEADING TO HORMONAL IMBALANCE AND INFLAMMATION IN THE TISSUE. THE RELATIONSHIP BETWEEN STRESS AND ILLNESS IS COMPLEX; ALL CHRONIC ILLNESSES SUCH AS CARDIOVASCULAR DISEASE AND ASTHMA HAVE THEIR ROOT IN CHRONIC STRESS ATTRIBUTED BY INFLAMMATION. IN RECENT TIMES, YOGA THERAPY HAS EMERGED AS AN IMPORTANT COMPLEMENTARY ALTERNATIVE MEDICINE FOR MANY HUMAN DISEASES. YOGA THERAPY HAS A POSITIVE IMPACT ON MIND AND BODY; IT ACTS BY INCORPORATING APPROPRIATE BREATHING TECHNIQUES AND MINDFULNESS TO ATTAIN CONSCIOUS DIRECTION OF OUR AWARENESS OF THE PRESENT MOMENT BY MEDITATION, WHICH HELPS ACHIEVE HARMONY BETWEEN THE BODY AND MIND. STUDIES HAVE ALSO DEMONSTRATED THE IMPORTANT REGULATORY EFFECTS OF YOGA THERAPY ON BRAIN STRUCTURE AND FUNCTIONS. DESPITE THESE ADVANCES, THE CELLULAR AND MOLECULAR MECHANISMS BY WHICH YOGA THERAPY RENDERS ITS BENEFICIAL EFFECTS ARE INADEQUATELY KNOWN. A GROWING BODY OF EVIDENCE SUGGESTS THAT YOGA THERAPY HAS IMMUNOMODULATORY EFFECTS. HOWEVER, THE PRECISE MECHANISTIC BASIS HAS NOT BEEN ADDRESSED EMPIRICALLY. IN THIS REVIEW, WE HAVE ATTEMPTED TO HIGHLIGHT THE EFFECT OF YOGA THERAPY ON IMMUNE SYSTEM FUNCTIONING WITH AN AIM TO IDENTIFY IMPORTANT IMMUNOLOGICAL SIGNATURES THAT INDEX THE EFFECT OF YOGA THERAPY. TOWARD THIS, WE HAVE SUMMARIZED THE AVAILABLE SCIENTIFIC EVIDENCE SHOWING POSITIVE IMPACTS OF YOGA THERAPY. FINALLY, WE HAVE EMPHASIZED THE EFFICACY OF YOGA IN IMPROVING PHYSICAL AND MENTAL WELL-BEING. YOGA HAS BEEN A PART OF INDIAN CULTURE AND TRADITION FOR LONG; NOW, THE TIME HAS COME TO SCIENTIFICALLY VALIDATE THIS AND IMPLEMENT THIS AS AN ALTERNATIVE TREATMENT METHOD FOR STRESS-RELATED CHRONIC DISEASE. 2020 19 1342 22 HOW YOGA HELPS HEAL INTERPERSONAL TRAUMA: PERSPECTIVES AND THEMES FROM 11 INTERPERSONAL TRAUMA SURVIVORS. TRAUMA IS UBIQUITOUS IN OUR SOCIETY; THEREFORE, IT IS IMPORTANT TO EXPLORE HOW INDIVIDUALS CULTIVATE HEALING AFTER TRAUMATIC EXPERIENCES. YOGA MAY BE ONE AVENUE TO CULTIVATE HEALING. QUALITATIVE METHODS WERE EMPLOYED TO STUDY THE ROLE YOGA PRACTICE PLAYED IN THE HEALING PROCESS OF THOSE WHO EXPERIENCED INTERPERSONAL TRAUMA. ELEVEN INTERPERSONAL TRAUMA SURVIVORS WHO PRACTICED YOGA REGULARLY WERE IDENTIFIED THROUGH A CRITERION SAMPLING METHOD. DATA ANALYSIS REVEALED THAT THE EMPHASIS OF YOGA ON MIND AND PHYSICAL BODY FOSTERED NUMEROUS POSITIVE OUTCOMES, SUCH AS SPIRITUAL GROWTH, SELF-ACCEPTANCE, ALLEVIATION OF TRAUMA-RELATED SYMPTOMS, AND INCREASED FEELINGS OF SELF-COMPASSION, EMPOWERMENT, AND SERENITY. OUR FINDINGS SUGGEST THAT YOGA MAY BE HELPFUL TO REGAIN MENTAL AND PHYSICAL HEALTH, FOSTER WELLBEING, AND CULTIVATE PERSONAL GROWTH AFTER INTERPERSONAL TRAUMA. 2016 20 2668 33 YOGA IN MAJOR DEPRESSIVE DISORDER: MOLECULAR MECHANISMS AND CLINICAL UTILITY. MAJOR DEPRESSIVE DISORDER (MDD) IS A MIND-BODY DISORDER. CELLULAR AGING HAS BEEN IMPLICATED IN THE PATHOGENESIS OF MDD WITH THE ALTERED MIND-BODY COMMUNICATION MARKERS LIKE STRESS RESPONSE, IMMUNE RESPONSE, NUTRITION SENSING, AND A RANGE OF OTHER REGULATORY FEEDBACK SYSTEMS. IN THIS AGE OF SUPER SPECIALIZATIONS, ONE SPECIFIC TARGET AND INTERVENTIONS (PREFERABLY A DRUG) ON IT ARE BEING RIGOROUSLY SOUGHT BY THE HEALTH CARE COMMUNITY AND INDUSTRY, BUT HAVE FAILED IN IT IN THE LAST FIFTY YEARS IN SPITE OF ADVANCES IN TECHNOLOGY. SINCE, DEPRESSION IS A COMPLEX DISORDER ASSOCIATED WITH INCREASED INCIDENCE OF OTHER COMPLEX DISORDERS, IT MUST BE TREATED BY AN INTEGRATED HOLISTIC APPROACH THAT CAN ADDRESS THE COMPLEXITY OF MDD. INTERVENTIONS TARGETING ACCELERATED BIOLOGICAL AGING TO INCREASE CELLULAR HEALTH IN WHOLE BODY HAVE POTENTIAL TO MANAGE COMPLEX CONDITIONS LIKE MDD AND ITS OVERLAPPING SYMPTOMS AND COMORBIDITIES. YOGA HAS THE POTENTIAL TO BE THE NEXUS BETWEEN, CLINICAL MANAGEMENT OF MDD AND OTHER LIFESTYLE DISEASES. 2021