1 1634 163 MODELING THE EFFECTS OF YOGA ON THE PROGRESSION OF ALZHEIMER'S DISEASE IN A DISH. ALZHEIMER'S DISEASE (AD) ACCOUNTS FOR 80% OF ALL DEMENTIA CASES, MAKING IT THE MOST COMMON FORM OF DEMENTIA. AGING SERVES AS THE MAIN RISK FACTOR FOR AD, BUT EARLY ONSET AD CAN ALSO OCCUR IN INDIVIDUALS YOUNGER THAN 65 YEARS. AD RESULTS FROM PROGRESSIVE NEURODEGENERATION LEADING TO DYSFUNCTIONAL SYNAPTIC TRANSMISSION IN THE BRAIN. THE CASCADE HYPOTHESIS OF AD STATES THAT AMYLOID PRECURSOR PROTEIN (APP) METABOLISM BECOMES IMPAIRED EITHER BY MUTATION OR AN INTERLEUKIN-MEDIATED STRESS RESPONSE TO INJURY, RESULTING IN THE SPLICING OF HARMFUL OLIGOMERIC FORMS OF AMYLOID BETA (ABETA). THESE OLIGOMERS DISRUPT EXTRACELLULAR RECEPTOR BINDING, INTRACELLULAR FUNCTION, AND CELLULAR MEMBRANE INTEGRITY. YOGA AND MEDITATIVE PRACTICES SLOW THE PROGRESSION OF THE COGNITIVE DECLINE ASSOCIATED WITH AD. HOWEVER, THE BIOLOGICAL MECHANISMS UNDERLYING THIS THERAPEUTIC EFFECT REMAIN ELUSIVE. HERE, WE INVESTIGATED THE ABILITY OF NEUROTRANSMITTERS RELEASED DURING YOGA AND MEDITATIVE PRACTICES TO RESCUE NEURONS FROM SYNAPTIC DYSFUNCTION IN AN IN VITRO ALZHEIMER'S MODEL CREATED BY CULTURING BASAL FOREBRAIN CHOLINERGIC NEURONS WITH PHYSIOLOGICALLY RELEVANT LEVELS OF THE I-42 ISOFORM OF OLIGOMERIC ABETA (OALPHABETAI-42). WE FOUND THAT THE NEUROTRANSMITTERS DOPAMINE AND HISTAMINE PRODUCE A COOPERATIVE ACTION WITH SEROTONIN TO REVERSE THE LOSS OF CHOLINE ACETYLTRANSFERASE (CHAT) BY OALPHABETAI-42. THE LOSS OF CHAT, THE ENZYME RESPONSIBLE FOR PROCESSING THE CHOLINERGIC NEUROTRANSMITTER ACETYLCHOLINE, CONTRIBUTES TO THE SYNAPTIC DYSFUNCTION EXPERIENCED DURING AD. THESE NEUROTRANSMITTERS INHIBIT NITRIC OXIDE SYNTHESIS CAUSED BY OALPHABETAI-42, PREVENTING OXIDATIVE AND NITROSATIVE STRESS. SEROTONIN ACTIVATES AN ALTERNATE CLEAVAGE OF APP TO PRODUCE A FRAGMENT WITH KNOWN NEUROTROPHIC EFFECTS, GIVING IT THE UNIQUE ABILITY TO INHIBIT THE OALPHABETAI-42 PRODUCTION CYCLE. WE HYPOTHESIZE HERE THAT THESE CONCERTED ACTIONS LEAD TO THE PROTECTION OF CHOLINERGIC SYNAPTIC TRANSMISSION IN AD. 2018 2 2642 19 YOGA FOR WOMEN LIVING WITH BREAST CANCER-RELATED ARM MORBIDITY: FINDINGS FROM AN EXPLORATORY STUDY. TREATMENTS FOR BREAST CANCER ASSAULT THE BODY AND CAN DISRUPT THE RELATIONSHIP BETWEEN BODY, MIND, AND SPIRIT. IN THIS ARTICLE, WE DISCUSS THE WAYS IN WHICH YOGA WAS EXPERIENCED AND UNDERSTOOD AS A HEALING THERAPY AMONG TEN FEMALE BREAST CANCER SURVIVORS BETWEEN THE AGES OF 26 AND 70 AND LIVING WITH TREATMENT-RELATED ARM MORBIDITY. THE WOMEN PARTICIPATED IN 6 WEEKLY SESSIONS OF GENTLE IYENGAR YOGA AND RESPONDED TO OPEN-ENDED SURVEYS BEFORE AND AFTER THE INTERVENTION. THE MAJORITY OF WOMEN REPORTED PHYSICAL, EMOTIONAL, AND SPIRITUAL BENEFITS FROM THE PRACTICE OF YOGA. SPECIFIC BENEFITS INCLUDED IMPROVEMENTS IN PHYSICAL FUNCTION AND RELIEF FROM SYMPTOMS RELATED TO TREATMENT; INCREASED PEACE OF MIND AND HOPE; AND CONNECTION TO OTHER YOGA PARTICIPANTS. INTEGRAL TO THIS HEALING PROCESS WAS SOCIAL SUPPORT FROM OTHER BREAST CANCER SURVIVORS. 2011 3 233 18 A SYSTEMATIC REVIEW OF YOGA FOR STATE ANXIETY: CONSIDERATIONS FOR OCCUPATIONAL THERAPY. BACKGROUND: STATE ANXIETY CAN RESULT FROM A VARIETY OF LIFE SITUATIONS. THIS TYPE OF ANXIETY CAN DISRUPT OCCUPATIONAL ENGAGEMENT AND PERFORMANCE, THEREBY AFFECTING REHABILITATION AND RECOVERY. OCCUPATIONAL THERAPISTS NEED TO ADDRESS THE CONNECTION BETWEEN MIND-BODY-SPIRIT AND ITS RELATIONSHIP TO PERFORMANCE AND ENGAGEMENT IN MEANINGFUL OCCUPATIONS. YOGA, WHEN USED AS AN ADJUNCT TO THERAPY, HAS THE POTENTIAL TO ADDRESS STATE ANXIETY. PURPOSE: THE AIM WAS TO SYSTEMATICALLY REVIEW THE EVIDENCE CONCERNING THE EFFECTIVENESS OF YOGA AS A TREATMENT APPROACH FOR STATE ANXIETY. METHODS: SIX ELECTRONIC DATABASES, THE AUTHORS' OWN FILES, AND THE REFERENCES OF INCLUDED STUDIES FROM 1990 TO JULY 2011 WERE SEARCHED. FINDINGS: A TOTAL OF 25 UNIQUE STUDIES REPRESENTED BY 26 PUBLICATIONS MADE UP THE SAMPLE: TWO SYSTEMATIC REVIEWS; 16 RANDOMIZED CONTROLLED TRIALS, AND SEVEN PROSPECTIVE, CONTROLLED, NON-RANDOMIZED STUDIES. EVIDENCE SUGGESTS YOGA CAN BE A VIABLE THERAPEUTIC OPTION FOR REDUCING STATE ANXIETY IN CERTAIN SITUATIONS. IMPLICATIONS: IN MAKING THE DETERMINATION TO RECOMMEND YOGA AS AN INTERVENTION, OCCUPATIONAL THERAPISTS SHOULD CONSIDER THE CLIENT'S CIRCUMSTANCES AND VALUES AS WELL AS THE TYPE AND INTENSITY OF THE YOGA PROGRAM. 2013 4 26 20 'A TOOL TO HELP ME THROUGH THE DARKNESS': SUFFERING AND HEALING AMONG TEACHER-PRACTITIONERS OF ASHTANGA YOGA. YOGA IS WIDELY REGARDED AS BENEFICIAL FOR PHYSICAL AND EMOTIONAL HEALTH, AND AS A SAFE ANCILLARY INTERVENTION FOR MANAGING A RANGE OF PSYCHOLOGICAL CONDITIONS. EVIDENCE OF INJURY, HARM, AND ABUSE IN YOGA TRADITIONS IS DIFFICULT TO SQUARE WITH THIS EMPHASIS ON HEALING. DRAWING MAINLY FROM ON ONLINE MEMOIRS BY LONG-TERM PRACTITIONERS OF ASHTANGA YOGA, THIS PAPER EXAMINES THE RELATIONSHIP BETWEEN SUFFERING AND HEALING IN YOGA, SHOWING HOW LONG-TERM ABUSE CAN BE PERPETUATED AND INJURY SUSTAINED IN A SYSTEM WIDELY UNDERSTOOD AND LABELLED BY ITS PRACTITIONERS AS THERAPEUTIC. THE PAPER ARGUES THAT ELEMENTS OF HEALING AND HARM ARE PRESENT IN THE RITUALS OF PRACTICE, THE CONCEPTS THAT SUPPORT IT, AND THE POWER STRUCTURE OF THE ASHTANGA SYSTEM. THE SYSTEM'S ORGANIZATIONAL DYNAMICS TOGETHER WITH A THERAPEUTIC DISCOURSE THAT LINKS SUFFERING TO ITS TRANSCENDENCE ENABLED THE SAME KINDS OF ABUSE AND TRAUMA THAT ASHTANGA YOGA IS PURPORTED TO HEAL. THE ANALYSIS RAISES QUESTIONS ABOUT THE OVERARCHING NARRATIVE OF YOGA AS SAFE AND HEALTHY, AND ABOUT THE CONNECTIONS BETWEEN HEALING AND HARM WITHIN THERAPEUTIC TRADITIONS. 2021 5 1669 31 NEUROPHYSIOLOGICAL AND NEUROCOGNITIVE MECHANISMS UNDERLYING THE EFFECTS OF YOGA-BASED PRACTICES: TOWARDS A COMPREHENSIVE THEORETICAL FRAMEWORK. DURING RECENT DECADES NUMEROUS YOGA-BASED PRACTICES (YBP) HAVE EMERGED IN THE WEST, WITH THEIR AIMS RANGING FROM FITNESS GAINS TO THERAPEUTIC BENEFITS AND SPIRITUAL DEVELOPMENT. YOGA IS ALSO BEGINNING TO SPARK GROWING INTEREST WITHIN THE SCIENTIFIC COMMUNITY, AND YOGA-BASED INTERVENTIONS HAVE BEEN ASSOCIATED WITH MEASUREABLE CHANGES IN PHYSIOLOGICAL PARAMETERS, PERCEIVED EMOTIONAL STATES, AND COGNITIVE FUNCTIONING. YBP TYPICALLY INVOLVE A COMBINATION OF POSTURES OR MOVEMENT SEQUENCES, CONSCIOUS REGULATION OF THE BREATH, AND VARIOUS TECHNIQUES TO IMPROVE ATTENTIONAL FOCUS. HOWEVER, SO FAR LITTLE IF ANY RESEARCH HAS ATTEMPTED TO DECONSTRUCT THE ROLE OF THESE DIFFERENT COMPONENT PARTS IN ORDER TO BETTER UNDERSTAND THEIR RESPECTIVE CONTRIBUTION TO THE EFFECTS OF YBP. A CLEAR OPERATIONAL DEFINITION OF YOGA-BASED THERAPEUTIC INTERVENTIONS FOR SCIENTIFIC PURPOSES, AS WELL AS A COMPREHENSIVE THEORETICAL FRAMEWORK FROM WHICH TESTABLE HYPOTHESES CAN BE FORMULATED, IS THEREFORE NEEDED. HERE WE PROPOSE SUCH A FRAMEWORK, AND OUTLINE THE BOTTOM-UP NEUROPHYSIOLOGICAL AND TOP-DOWN NEUROCOGNITIVE MECHANISMS HYPOTHESIZED TO BE AT PLAY IN YBP. 2015 6 2907 20 [ON THE METHODOLOGICAL APPROACH TO THE ELUCIDATION OF MECHANISMS UNDERLYING THERAPEUTIC EFFECTIVENESS OF CIGUN, INDIAN AND TIBETAN YOGA THERAPY]. THE METHODOLOGICAL APPROACH IS PROPOSED ALLOWING TO OBJECTIVELY CHARACTERIZE NEUROPHYSIOLOGICAL MECHANISMS UNDERLYING THERAPEUTIC EFFECTIVENESS OF CIGUN, INDIAN AND TIBETAN YOGA THERAPY. EXECUTION OF EXERCISES STIPULATED IN THESE PROGRAMS IS INTERPRETED AS A CONSCIOUSNESS-INSPIRED SPECIFIC FORM OF HUMAN BEHAVIOUR (ACTIVITY). STEP-BY-STEP ANALYSIS OF MENTALLY-ORGANIZED BODY'S FUNCTIONAL SYSTEMS AS A NEUROPHYSIOLOGICAL BASIS OF REALIZABLE BEHAVIOUR IS PRESENTED. OPERATIONAL INTERPRETATION OF INTERNAL MECHANISMS UNDERLYING THE SYSTEM'S FUNCTIONING PERMITS TO EVALUATE THE STEREOTYPE BRAIN CONDITION ACTUALIZED BY SPECIFIC REQUIREMENTS AND MOTIVATIONS THAT INITIATES SENSORY DEPRIVATION TO ENSURE PRIORITY REALIZATION OF INTERNAL GENETICALLY DETERMINED ACTIVITY OF THE HUMAN BODY. MOBILIZATION OF THIS INTERNAL ACTIVITY IS DESCRIBED AS A PROCESS OF SELECTIVE FORMATION OF MANY COMPLICATED INTERACTIONS BETWEEN VARIOUS STRUCTURES OF THE RETICULAR FORMATION, LIMBIC SYSTEM, SUBCORTICAL CENTRES, AND NEOCORTEX MAINTAINING PRIORITY FUNCTIONING OF HOMEOSTATIC MECHANISMS OF SELF-REGULATION AND INBORN HUMAN BEHAVIOUR. THESE MECHANISMS ARE BELIEVED TO UNDERLIE THE AUTORECONSTRUCTIVE POTENTIAL OF HUMAN ORGANISM BY ENSURING SYSTEMIC CORRECTION AND RESTORATION OF ITS FUNCTIONAL RESOURCES. 2010 7 2042 22 THE 'WORLD OF YOGA': THE PRODUCTION AND REPRODUCTION OF THERAPEUTIC LANDSCAPES. YOGA IS BECOMING MORE AND MORE FASHIONABLE ALL AROUND THE WORLD. THIS ACTIVITY, PARTLY CONSIDERED AS THERAPEUTIC, REVEALS CONTEMPORARY WAYS OF PRODUCING GLOBAL PRACTICES. VIA A QUESTIONNAIRE COMPLETED BY INDIVIDUALS AT YOGA CENTRES IN INDIA AND FRANCE, THE PAPER ANALYSES THIS PHENOMENON USING THE CONCEPT OF THERAPEUTIC LANDSCAPES. FURTHERMORE, IT EXAMINES HOW THESE THERAPEUTIC LANDSCAPES ARE INFLUENCED BY GLOBALISATION. BRINGING TOGETHER THE CONCEPTS OF THERAPEUTIC LANDSCAPES, GLOBALISATION AND THE PRACTICE OF YOGA, THE PAPER ANALYSES THE PRODUCTION AND REPRODUCTION OF YOGIC THERAPEUTIC LANDSCAPES IN THE WORLD'S SPACE. CONSTITUTED OF NATURAL PHYSICAL ELEMENTS AND BUILT STRUCTURES, THESE THERAPEUTIC LANDSCAPES ARE ALSO STRONGLY LINKED TO EMOTIONAL QUALITIES AND INTIMATE FEELINGS EVOKED BY THE PLACE AND RELATED TO HEALTH AND WELL-BEING. THE PAPER ALSO UNDERLINES THAT THE EMERGENCE OF INTERNATIONALLY RECOGNISED THERAPEUTIC LANDSCAPES DEMANDS A CULTURAL AND SOCIAL GEOGRAPHICAL APPROACH THAT COULD HELP TO EXAMINE THE REPERCUSSIONS OF LOCAL AND GLOBAL PHENOMENA ON THERAPEUTIC LANDSCAPES. INDEED, VERY OFTEN, YOGIS, ALL AROUND THE WORLD, REFER TO IDEAL PLACES WHERE THEY RARELY GO. CONSEQUENTLY, THEY CREATE AN IMAGINED THERAPEUTIC ENVIRONMENT THAT THE PAPER DESCRIBES. 2007 8 1704 17 PARTNER YOGA FOR ESTABLISHING BOUNDARIES IN RELATIONSHIP: A TRANSPERSONAL SOMATIC APPROACH. THIS ARTICLE IS WRITTEN FOR YOGA THERAPISTS AND PSYCHOTHERAPISTS WHO WORK WITH COUPLES WHO HAVE DIFFICULTY SETTING BOUNDARIES AND MAINTAINING INDIVIDUALITY IN THEIR RELATIONSHIPS. PARTNER YOGA, TRANSPERSONAL PSYCHOLOGY, AND SOMATIC-BASED PSYCHOLOGY ARE APPROACHES THAT CAN PROVIDE CLIENTS WITH A HOLISTIC SYSTEM OF THERAPY TO ENCOURAGE HEALTHY BOUNDARIES AND EMOTIONAL CONNECTION. THE PROCESS OF PARTNER YOGA IS DESCRIBED FROM A TRANSPERSONAL, SOMATICALLY ORIENTED APPROACH. EXAMPLES OF SPECIFIC ASANAS, OR YOGA POSES, ARE DISCUSSED ALONGSIDE THE SPECIAL CONSIDERATIONS THAT A THERAPIST MUST CONSIDER WHEN EXPLORING BOUNDARIES AND COMMUNICATION THROUGH PARTNER YOGA. INSIGHTS FROM INDIVIDUAL CASE SESSIONS WITH COUPLES ARE INCLUDED TO ILLUSTRATE THE PROCESS OF DIFFERENTIATION AND THE POSSIBILITY OF EXPERIENCING A TRANSPERSONAL UNION THROUGH PARTNER YOGA. 2011 9 2714 31 YOGA LESSONS FOR CONSCIOUSNESS RESEARCH: A PARALIMBIC NETWORK BALANCING BRAIN RESOURCE ALLOCATION. CONSCIOUSNESS HAS BEEN PROPOSED TO PLAY A KEY ROLE IN SHAPING FLEXIBLE LEARNING AND AS SUCH IS THOUGHT TO CONFER AN EVOLUTIONARY ADVANTAGE. ATTENTION AND AWARENESS ARE THE PERHAPS MOST IMPORTANT UNDERLYING PROCESSES, YET THEIR PRECISE RELATIONSHIP IS PRESENTLY UNCLEAR. BOTH OF THESE PROCESSES MUST, HOWEVER, SERVE THE EVOLUTIONARY IMPERATIVES OF SURVIVAL AND PROCREATION. THEY ARE THUS INTIMATELY BOUND BY REWARD AND EMOTION TO HELP TO PRIORITIZE EFFICIENT BRAIN RESOURCE ALLOCATION IN ORDER TO PREDICT AND OPTIMIZE BEHAVIOR. HERE WE SHOW HOW THIS PROCESS IS SERVED BY A PARALIMBIC NETWORK CONSISTING PRIMARILY OF REGIONS LOCATED ON THE MIDLINE OF THE HUMAN BRAIN. USING MANY DIFFERENT TECHNIQUES, EXPERIMENTS HAVE DEMONSTRATED THAT THIS NETWORK IS EFFECTIVE AND SPECIFIC FOR SELF-AWARENESS AND CONTRIBUTES TO THE SENSE OF UNITY OF CONSCIOUSNESS BY ACTING AS A COMMON NEURAL PATH FOR A WIDE VARIETY OF CONSCIOUS EXPERIENCES. INTERESTINGLY, HEMODYNAMIC ACTIVITY IN THE NETWORK DECREASES WITH FOCUSING ON EXTERNAL STIMULI, WHICH HAS LED TO THE IDEA OF A DEFAULT MODE NETWORK. THIS NETWORK IS ONE OF MANY NETWORKS THAT WAX AND VANE AS RESOURCES ARE ALLOCATED TO ACCOMMODATE THE DIFFERENT CYCLICAL NEEDS OF THE ORGANISM PRIMARILY RELATED TO THE FUNDAMENTAL PLEASURES AFFORDED BY EVOLUTION: FOOD, SEX, AND CONSPECIFICS. HERE WE HYPOTHESIZE, HOWEVER, THAT THE PARALIMBIC NETWORK SERVES A CRUCIAL ROLE IN BALANCING AND REGULATING BRAIN RESOURCE ALLOCATION, AND DISCUSS HOW IT CAN BE THOUGHT OF AS A LINK BETWEEN CURRENT THEORIES OF SO-CALLED "DEFAULT MODE," "RESTING STATE NETWORKS," AND "GLOBAL WORKSPACE." WE SHOW HOW MAJOR DEVELOPMENTAL DISORDERS OF SELF-AWARENESS AND SELF-CONTROL CAN ARISE FROM PROBLEMS IN THE PARALIMBIC NETWORK AS DEMONSTRATED HERE BY THE EXAMPLE OF ASPERGER SYNDROME. WE CONCLUDE THAT ATTENTION, AWARENESS, AND EMOTION ARE INTEGRATED BY A PARALIMBIC NETWORK THAT HELPS TO EFFICIENTLY ALLOCATE BRAIN RESOURCES TO OPTIMIZE BEHAVIOR AND HELP SURVIVAL. 2011 10 2297 21 THERAPEUTIC ROLE OF YOGA IN NEUROPSYCHOLOGICAL DISORDERS. YOGA IS CONSIDERED A WIDELY-USED APPROACH FOR HEALTH CONSERVATION AND CAN BE ADOPTED AS A TREATMENT MODALITY FOR A PLETHORA OF MEDICAL CONDITIONS, INCLUDING NEUROLOGICAL AND PSYCHOLOGICAL DISORDERS. HENCE, WE REVIEWED RELEVANT ARTICLES ENTAILING VARIOUS NEUROLOGICAL AND PSYCHOLOGICAL DISORDERS AND GATHERED DATA ON HOW YOGA EXERTS POSITIVE IMPACTS ON PATIENTS WITH A DIVERSE RANGE OF DISORDERS, INCLUDING ITS MODULATORY EFFECTS ON BRAIN BIOELECTRICAL ACTIVITIES, NEUROTRANSMITTERS, AND SYNAPTIC PLASTICITY. THE ROLE OF YOGA PRACTICE AS AN ELEMENT OF THE TREATMENT OF SEVERAL NEUROPSYCHOLOGICAL DISEASES WAS EVALUATED BASED ON THESE FINDINGS. 2021 11 2211 22 THE HEALTH IMAGINARY OF POSTURAL YOGA. THIS PAPER EXPLORES THE CAPACITY OF YOGA NARRATIVES AND PRACTICES TO CONTRIBUTE TO AND RELATE IDEAS ABOUT HEALTH. IT ADDS THEORETICALLY TO EXISTING LITERATURE ON YOGA BY INTRODUCING THE CONCEPT OF THE 'HEALTH IMAGINARY' AS AN ANALYTIC LENS FOR CONSIDERING YOGA DISCOURSES IN LATE MODERN TIMES, WHERE PERSONAL HEALTH CARE AND SPIRITUAL AMBITIONS ARE ONCE AGAIN BECOMING BLURRED. WITH THIS PERSPECTIVE, THE PAPER PROVIDES A THOROUGH ANALYSIS OF HOW YOGA POSTURES (ASANAS) ARE CONCEIVED TO WORK THERAPEUTICALLY, IN YOGA'S RECENT HISTORY AND IN PRESENT-DAY YOGA THERAPY. TAKING CASE STUDIES FROM INDIA AND GERMANY, IT IS SHOWN EMPIRICALLY HOW THE APPLICATION OF ASANAS IS RATIONALIZED DIFFERENTLY IN SPECIFIC GEOGRAPHICAL AND THERAPEUTIC ENVIRONMENTS - PARTICULARLY REGARDING THE PRESUMED THEORY OF THE BODY. THUS, THE CONCEPT OF THE HEALTH IMAGINARY NOT ONLY PROVIDES ANALYTIC SPACE TO EXPLORE THE IMPLICIT LOGICS AND GOALS OF HEALING IN DIFFERENT CONTEXTS, BUT ALSO OFFERS CLUES ABOUT THE DISTINCT SOCIAL, CULTURAL/RELIGIOUS, AND LOCAL INFLUENCES THAT DRAW PEOPLE INTO YOGA AND CONTRIBUTE TO ITS SELECTIVE APPROPRIATION ACROSS THE GLOBE. 2021 12 1347 40 HYPOXIA IN CNS PATHOLOGIES: EMERGING ROLE OF MIRNA-BASED NEUROTHERAPEUTICS AND YOGA BASED ALTERNATIVE THERAPIES. CELLULAR RESPIRATION IS A VITAL PROCESS FOR THE EXISTENCE OF LIFE. ANY CONDITION THAT RESULTS IN DEPRIVATION OF OXYGEN (ALSO TERMED AS HYPOXIA) MAY EVENTUALLY LEAD TO DELETERIOUS EFFECTS ON THE FUNCTIONING OF TISSUES. BRAIN BEING THE HIGHEST CONSUMER OF OXYGEN IS PRONE TO INCREASED RISK OF HYPOXIA-INDUCED NEUROLOGICAL INSULTS. THIS IN TURN HAS BEEN ASSOCIATED WITH MANY DISEASES OF CENTRAL NERVOUS SYSTEM (CNS) SUCH AS STROKE, ALZHEIMER'S, ENCEPHALOPATHY ETC. ALTHOUGH SEVERAL STUDIES HAVE INVESTIGATED THE PATHOPHYSIOLOGICAL MECHANISMS UNDERLYING ISCHEMIC/HYPOXIC CNS DISEASES, THE KNOWLEDGE ABOUT PROTECTIVE THERAPEUTIC STRATEGIES TO AMELIORATE THE AFFECTED NEURONAL CELLS IS MEAGER. THIS HAS AUGMENTED THE NEED TO IMPROVE OUR UNDERSTANDING OF THE HYPOXIC AND ISCHEMIC EVENTS OCCURRING IN THE BRAIN AND IDENTIFY NOVEL AND ALTERNATE TREATMENT MODALITIES FOR SUCH INSULTS. MICRORNA (MIRNAS), SMALL NON-CODING RNA MOLECULES, HAVE RECENTLY EMERGED AS POTENTIAL NEUROPROTECTIVE AGENTS AS WELL AS TARGETS, UNDER HYPOXIC CONDITIONS. THESE 18-22 NUCLEOTIDE LONG RNA MOLECULES ARE PROFUSELY PRESENT IN BRAIN AND OTHER ORGANS AND FUNCTION AS GENE REGULATORS BY CLEAVING AND SILENCING THE GENE EXPRESSION. IN BRAIN, THESE ARE KNOWN TO BE INVOLVED IN NEURONAL DIFFERENTIATION AND PLASTICITY. THEREFORE, TARGETING MIRNA EXPRESSION REPRESENTS A NOVEL THERAPEUTIC APPROACH TO INTERCEDE AGAINST HYPOXIC AND ISCHEMIC BRAIN INJURY. IN THE FIRST PART OF THIS REVIEW, WE WILL DISCUSS THE NEUROPHYSIOLOGICAL CHANGES CAUSED AS A RESULT OF HYPOXIA, FOLLOWED BY THE CONTRIBUTION OF HYPOXIA IN THE NEURODEGENERATIVE DISEASES. SECONDLY, WE WILL PROVIDE RECENT UPDATES AND INSIGHTS INTO THE ROLES OF MIRNA IN THE REGULATION OF GENES IN OXYGEN AND GLUCOSE DEPRIVED BRAIN IN ASSOCIATION WITH CIRCADIAN RHYTHMS AND HOW THESE CAN BE TARGETED AS NEUROPROTECTIVE AGENTS FOR CNS INJURIES. FINALLY, WE WILL EMPHASIZE ON ALTERNATE BREATHING OR YOGIC INTERVENTIONS TO OVERCOME THE HYPOXIA ASSOCIATED ANOMALIES THAT COULD ULTIMATELY LEAD TO IMPROVEMENT IN CEREBRAL PERFUSION. 2017 13 433 25 CAN YOGA THERAPY STIMULATE STEM CELL TRAFFICKING FROM BONE MARROW? IT HAS BEEN ESTABLISHED THAT MESENCHYMAL STROMAL CELLS (MSCS) FROM BONE MARROW ENTER THE PERIPHERAL CIRCULATION INTERMITTENTLY FOR POSSIBLE TISSUE REGENERATION, REPAIR AND TO TAKE CARE OF DAILY WEAR AND TEAR. THIS IS EVIDENT FROM THE DETECTION OF MSCS FROM PERIPHERAL BLOOD. THE FACTORS GOVERNING THIS MIGRATION REMAIN ELUSIVE. THESE MSCS CARRY OUT THE WORK OF POLICING AND ARE SUPPOSED TO REPAIR THE INJURED TISSUES. THUS, THESE CELLS HELP IN MAINTAINING THE TISSUE AND ORGAN HOMEOSTASIS. YOGA AND PRANAYAMA ORIGINATED IN INDIA AND IS NOW BEING PRACTICED ALL OVER THE WORLD FOR POSITIVE HEALTH. SO FAR, THE CHEMICAL STIMULATION OF BONE MARROW HAS BEEN WIDELY USED EMPLOYING INJECTION OF COLONY STIMULATING FACTOR. HOWEVER, THE ROLE OF PHYSICAL FACTORS SUCH AS MECHANICAL STIMULATION AND STRETCHING HAS NOT BEEN SUBSTANTIATED. IT IS CLAIMED THAT PRACTICING YOGA DELAYS SENESCENCE, IMPROVES THE PHYSIOLOGICAL FUNCTIONS OF HEART AND LUNG AND YOGA POSTURES MAKE THE BODY ELASTIC. IT REMAINS TO BE SEEN WHETHER THE YOGA THERAPY PROMOTES TRAFFICKING OF THE STEM CELLS FROM BONE MARROW FOR POSSIBLE REPAIR AND REGENERATION OF WORN OUT AND DEGENERATING TISSUES. WE COVER IN THIS SHORT REVIEW, MAINLY THE ROLE OF PHYSICAL FACTORS ESPECIALLY THE YOGA THERAPY ON STEM CELLS TRAFFICKING FROM BONE MARROW. 2016 14 2224 27 THE IMPACT OF THE "YOGIC LIFESTYLE" ON CANCER PROGNOSIS AND SURVIVAL: CAN WE TARGET CANCER STEM CELLS WITH YOGA? CANCER HAS RECENTLY BEEN KNOWN TO ORIGINATE FROM STEM CELL-LIKE CELLS, CALLED CANCER STEM CELLS (CSCS). THEIR UNIQUE PROPERTIES OF SELF-DUPLICATION, MULTIPLICATION, AS WELL AS MIGRATION GIVE THE CSC RESISTANCE OVER CONVENTIONAL CANCER THERAPIES. NEWER THERAPIES ARE IN DEVELOPMENTAL STAGE TO TARGET THESE STEM CELL-LIKE POPULATIONS AND BECOME THE VANGUARD OF FUTURE TREATMENTS. SEVERAL COMPLEMENTARY AND ALTERNATIVE TREATMENTS HAVE BEEN USED IN CANCER MANAGEMENT AS AN ADJUNCT TO CONVENTIONAL THERAPY TO IMPROVE THE OVERALL QUALITY OF LIFE AND REDUCE RECURRENCE. YOGA STANDS AS THE THIRD MOST POPULAR OF ALL COMPLEMENTARY AND ALTERNATIVE MEDICINE TREATMENTS CURRENTLY USED IN CANCER PATIENTS TODAY. PRELIMINARY RESULTS SHOW THAT YOGA MODULATES NEURAL, HORMONAL, AND IMMUNE FUNCTIONS AT A CELLULAR LEVEL. THE SCOPE OF THIS COMMENTARY IS TO DISCUSS THE CURRENT EVIDENCE-BASED MEDICINE ON YOGA AND ITS EFFECT ON CSCS. 2017 15 2886 31 YOGA: BALANCING THE EXCITATION-INHIBITION EQUILIBRIUM IN PSYCHIATRIC DISORDERS. SOCIAL BEHAVIORAL DISTURBANCES ARE CENTRAL TO MOST PSYCHIATRIC DISORDERS. A DISEQUILIBRIUM WITHIN THE CORTICAL EXCITATORY AND INHIBITORY NEUROTRANSMITTER SYSTEMS UNDERLIES THESE DEFICITS. GAMMA-AMINOBUTYRIC ACID (GABA) AND GLUTAMATE ARE THE MOST ABUNDANT EXCITATORY AND INHIBITORY NEUROTRANSMITTERS IN THE BRAIN THAT CONTRIBUTE TO THIS EQUILIBRIUM. SEVERAL CONTEMPORARY THERAPIES USED IN TREATING PSYCHIATRIC DISORDERS, REGULATE THIS GABA-GLUTAMATE BALANCE. YOGA HAS BEEN STUDIED AS AN ADJUVANT TREATMENT ACROSS A BROAD RANGE OF PSYCHIATRIC DISORDERS AND IS SHOWN TO HAVE SHORT-TERM THERAPEUTIC GAINS. EMERGING EVIDENCE FROM RECENT CLINICAL IN VIVO EXPERIMENTS SUGGESTS THAT YOGA IMPROVES GABA-MEDIATED CORTICAL-INHIBITORY TONE AND ENHANCES PERIPHERAL OXYTOCIN LEVELS. THIS IS LIKELY TO HAVE A MORE CONTROLLED DOWNSTREAM RESPONSE OF THE HYPOTHALAMO-PITUITARY-ADRENAL SYSTEM BY MEANS OF REDUCED CORTISOL RELEASE AND HENCE A BLUNTED SYMPATHETIC RESPONSE TO STRESS. ANIMAL AND EARLY FETAL DEVELOPMENTAL STUDIES SUGGEST AN INTER-DEPENDENT ROLE OF OXYTOCIN AND GABA IN REGULATING SOCIAL BEHAVIORS. IN KEEPING WITH THESE OBSERVATIONS, WE PROPOSE AN INTEGRATED NEUROBIOLOGICAL MODEL TO STUDY THE MECHANISMS OF THERAPEUTIC BENEFITS WITH YOGA. APART FROM PROVIDING A NEUROSCIENTIFIC BASIS FOR APPLYING A TRADITIONAL SYSTEM OF PRACTICE IN THE CLINICAL SETTING, THIS MODEL CAN BE USED AS A FRAMEWORK FOR STUDYING YOGA MECHANISMS IN FUTURE CLINICAL TRIALS. 2019 16 1418 26 IMPORTANT FACTORS AFFECTING USER EXPERIENCE DESIGN AND SATISFACTION OF A MOBILE HEALTH APP-A CASE STUDY OF DAILY YOGA APP. IN RECENT YEARS, MOBILE HEALTH (MHEALTH) HAS GAINED POPULARITY. YOGA APPS HELP USERS TO EXERCISE AT HOME AND IMPROVE THEIR HEALTH. IT IS WORTH DISCUSSING HOW TO GIVE YOGIS A BETTER EXPERIENCE AND HIGHER SATISFACTION TO IMPROVE THEIR WILLINGNESS TO KEEP USING YOGA APPS. IN THIS STUDY, THE DAILY YOGA APP WAS SELECTED AS THE RESEARCH OBJECT TO EXPLORE IMPORTANT FACTORS RELATED TO ITS USER EXPERIENCE DESIGN AND USER SATISFACTION. THROUGH A LITERATURE REVIEW AND DELPHI METHOD COMPOSED OF EIGHT EXPERTS, THIS STUDY PUT FORWARD THE IMPORTANT CRITERIA FRAMEWORK OF USER EXPERIENCE DESIGN FOR THE DAILY YOGA APP AND THEN, USED THE DEMATEL (DECISION MAKING AND TRIAL EVALUATION LABORATORY)-BASED ANP (ANALYTIC NETWORK PROCESS) METHOD TO DETERMINE THE FACTORS' IMPORTANCE ORDER AND THE CAUSAL RELATIONSHIPS AMONG THEM. FINALLY, COMBINED WITH THE RESULTS OF AN IMPORTANCE-PERFORMANCE ANALYSIS OF 16 REAL USERS, WE DISCUSS THE IMPROVEMENT MEASURES. THE RESEARCH RESULTS SHOW THAT THE YOGA CLASS IS THE MOST CRITICAL FACTOR IN THE USER EXPERIENCE DESIGN OF THE DAILY YOGA APP, THE TARGET PLAN IS A FACTOR THAT IS IN GREAT NEED OF IMPROVEMENT, AND HAVING AN ATTRACTIVE INTERFACE CAN IMPROVE USER EXPERIENCE. THE EVALUATION MODEL OF THE STUDY CAN ACT AS A REFERENCE FOR IMPROVING USER EXPERIENCE WITH THE DAILY YOGA APP, AND CAN ALSO BE WIDELY USED IN THE PROCESS OF USER EXPERIENCE DESIGN, QUESTIONNAIRE PRODUCTION, AND EVALUATION OPTIMIZATION OF MHEALTH APP AND RELATED APPLICATIONS. 2020 17 2431 25 YOGA AND PHYSIOTHERAPY: A SPECULATIVE REVIEW AND CONCEPTUAL SYNTHESIS. THIS ARTICLE PRESENTS THE POTENTIAL INTEGRATION OF YOGA AND PHYSIOTHERAPY WHEN CONSIDERING THE ESSENCE OF THEIR UNDERLYING CONCEPTS. WITHIN THE SCOPE OF THIS ARTICLE THE EXISTENCE OF SEVERAL SIMILARITIES BETWEEN THESE TWO 'CONCEPTS' HAS BEEN SUGGESTED. RESEARCHERS, PHYSIOTHERAPISTS AND THEIR PATIENTS AS WELL AS YOGA PRACTITIONERS CAN OBTAIN VALUABLE AND ADDITIONAL ARGUMENTS THROUGH THE CROSS-FERTILIZATION OF IDEAS ACROSS PRESENTED STUDIES UNITED BY SHARED, UNDERLYING CONCEPTS. THE PRACTICE OF YOGA IS BASED ON THE FOLLOWING ASSUMPTIONS: COMPLEXITY AND MULTIDIMENSIONALITY, VARIOUS POSITIVE INFLUENCES ON AN INDIVIDUAL'S WHOLENESS THROUGH THE MIND, BODY, AND THE RELATIONSHIPS BETWEEN THEM. THESE ASSUMPTIONS MAY HAVE THE POTENTIAL TO CONTRIBUTE TOWARDS THE PRACTICE OF PHYSIOTHERAPY AND ITS UNDERLYING PRINCIPLES. THE ESSENCE OF PHYSIOTHERAPY AS A MULTIFACETED PROCESS REQUIRES TEAMWORK AND EFFORTS OF VARIOUS SPECIALISTS LIKE PSYCHOLOGISTS, SOCIOLOGISTS, OCCUPATIONAL THERAPISTS AND NURSES IF PATIENTS ARE TO BENEFIT. IDEALLY, THE PHYSIOTHERAPIST SHOULD POSSESS KNOWLEDGE FROM THESE AREAS OF SCIENCE IN ORDER TO PROFESSIONALLY CARE ABOUT PATIENTS. THEREFORE, IT CAN BE SUGGESTED THAT BASIC SIMILARITIES EXIST BETWEEN YOGA AND PHYSIOTHERAPY IN TERMS OF MUTIDISCIPLINARITY AND COMPLEXITY OF HOLISTIC CARE. SUCH CONCEPTUAL ENRICHMENT MAY BE A USEFUL SOURCE OF INSPIRATION FOR PHYSIOTHERAPISTS CONCERNED ABOUT THEIR PATIENTS' OVERALL HEALTH ON A DAILY BASIS. THE AUTHORS EMPHASIZE THE USEFULNESS OF YOGA PRACTICE IN CLINICAL UNITS AND EXPLAIN HOW THE ESSENCE OF AYURVEDIC KNOWLEDGE MIGHT BE EXTRAPOLATED AND INCORPORATED INTO THEORETICAL PRINCIPLES OF PHYSIOTHERAPY PROCESS. THE JUSTIFICATION OF THE STUDIES INCLUDED IS ALSO PRESENTED. 2009 18 203 28 A REVIEW OF THE LITERATURE EXAMINING THE PHYSIOLOGICAL PROCESSES UNDERLYING THE THERAPEUTIC BENEFITS OF HATHA YOGA. AN ESTIMATED 7.4 MILLION AMERICANS CURRENTLY PRACTICE HATHA YOGA. MOREOVER, 64% OF INDIVIDUALS WHO PRACTICE YOGA REPORT DOING SO FOR WELL-BEING. PREVIOUS RESEARCH HAS REPORTED AN ASSOCIATION BETWEEN YOGA PRACTICE AND SUBJECTIVE WELL-BEING; HOWEVER, FEW STUDIES HAVE INVESTIGATED THE PHYSIOLOGICAL MECHANISMS INVOLVED. THE FOLLOWING REVIEW PROVIDES AN HISTORICAL OVERVIEW OF THE FIELD OF INTEGRATIVE MEDICINE, WHICH CONCEPTUALIZES YOGA AS A MIND-BODY PRACTICE. A BRIEF DESCRIPTION OF HATHA YOGA IS PROVIDED THAT DESCRIBES THE PURPORTED RELATIONSHIP BETWEEN YOGA AND THE RELAXATION RESPONSE. A REVIEW OF THE EMERGING LITERATURE RELATED TO NITRIC OXIDE AND OXIDATIVE STRESS AS POTENTIAL MECHANISMS IN THE RELATIONSHIP BETWEEN YOGA AND WELL-BEING ALSO IS INCLUDED. THE ARTICLE CONCLUDES WITH A BRIEF DISCUSSION OF THE STATE OF THE RESEARCH AND PROVIDES SUGGESTIONS FOR FUTURE STUDIES. 2008 19 2373 25 WHAT IS OUR "EPISTEMIC RESPONSIBILITY"? REFLECTIONS ON SOCIAL WORK'S ORIENTATION IN YOGA THERAPY RESEARCH. THE PURPOSE OF THIS ARTICLE IS TO EXPLORE HOW THE SOCIAL WORK DISCIPLINE COULD PROVIDE A COMPLEMENTARY LENS THROUGH WHICH YOGA THERAPY CAN BE ANALYZED AND EVALUATED BY ENGAGING IN KNOWLEDGE-CREATION PRACTICES AND PROCEDURES THAT PRIORITIZE THE "EPISTEMIC RESPONSIBILITY" DESCRIBED BY PHILOSOPHER LORRAINE CODE. MORE SPECIFICALLY, BY SEEKING TO STRATEGICALLY INCLUDE OFTEN-SUBJUGATED TYPES OF KNOWLEDGE AND BY FOCUSING ON REDISTRIBUTING EPISTEMIC POWER TO AGENTS THAT TYPICALLY HAVE BEEN EXCLUDED FROM EPISTEMIC PARTICIPATION IN CONTEMPORARY YOGA THERAPY RESEARCH, THE SOCIAL WORK DISCIPLINE, WITH ITS STRONG COMMITMENT TO SOCIAL JUSTICE, HAS THE POTENTIAL TO CONTRIBUTE TO FILLING AN IMPORTANT GAP IN SCIENTIFIC LITERATURE. WE BEGIN BY PRESENTING THE RELEVANCE OF THE SOCIAL WORK PERSPECTIVE IN RELATION TO THE FIELD OF YOGA THERAPY. WE NEXT OFFER A RESERVED CRITICAL ANALYSIS OF THE DOMINANT TECHNICAL KNOWLEDGE BASE THAT CURRENTLY INFORMS YOGA THERAPY PRACTICE. THIS ANALYSIS HIGHLIGHTS THE SOCIAL PARAMETERS THAT MAY BE RENDERED INVISIBLE OR LEFT ASIDE WHEN ADOPTING A POSITIVIST EPISTEMOLOGICAL LENS AND JUSTIFIES HOW THE CONCEPTUAL APPARATUS OF EPISTEMIC RESPONSIBILITY SERVES AS A POTENTIAL PLATFORM FOR RETHINKING SOCIAL WORK'S POSITION AND FUTURE CONTRIBUTIONS TO THE FIELD OF YOGA THERAPY. FINALLY, WE MOBILIZE THE CONCEPT OF CULTURAL APPROPRIATION TO ILLUSTRATE HOW STRIVING FOR EPISTEMIC RESPONSIBILITY PROVIDES AN ENTRY POINT FOR ADDRESSING THE MULTILEVEL, COMPLEX SOCIAL PROCESSES EMBEDDED IN YOGA THERAPY PRACTICE AND RESEARCH WHILE AIMING TO CAPTURE THE MANY VOICES-AND HENCE THE VARIOUS TRUTHS-IMPLICATED IN A DEMOCRATIC, REFLEXIVE, AND INCLUSIVE RESEARCH PROCESS. 2020 20 1878 17 REALIZING YOGA'S ALL-ACCESS PASS: A SOCIAL JUSTICE CRITIQUE OF WESTERNIZED YOGA AND INCLUSIVE EMBODIMENT. IN THE 21(ST) CENTURY, THE ANCIENT MIND-BODY PRACTICE OF YOGA HAS SURGED IN POPULARITY AMONG WESTERN ENTHUSIASTS FOR ITS NUMEROUS HEALTH BENEFITS. PARTICULARLY, A GROWING EVIDENCE BASE SUPPORTS YOGA FOR CULTIVATING POSITIVE EMBODIMENT AND REDUCING RISK FOR DISORDERED EATING. NEVERTHELESS, AMIDST ITS RISE ARE CONCERNS ABOUT YOGA'S DEPARTURE FROM ITS SPIRITUAL FOUNDATIONS AND INCREASING ASSIMILATION INTO THE APPEARANCE- AND COMMERCIAL-DRIVEN EXERCISE AND FITNESS CULTURE. CONSEQUENTLY, AN EXCLUSIONARY IDENTITY HAS BEEN PERPETUATED IN SHAPING NORMS SURROUNDING WHO CAN AND DOES PRACTICE YOGA, WHICH CONTRADICTS EARLIER EGALITARIAN VISIONS OF A YOGA FOR ALL. THEREFORE, WE ADOPT A SOCIAL JUSTICE LENS IN OFFERING A FOCUSED ANALYSIS OF THE INTERSECTION OF YOGA, EMBODIMENT, AND INCLUSION FOR SELECT MARGINALIZED SOCIAL IDENTITIES TYPICALLY UNDERREPRESENTED AMONG YOGA PRACTITIONERS AND IN YOGA SCHOLARSHIP. DATA ARE SYNTHESIZED FROM BOTH QUALITATIVE AND QUANTITATIVE SOURCES AND INTEGRATE AN UNDERSTANDING OF HOW CONFINED MEDIA REPRESENTATIONS OF "THE YOGA BODY" AND OTHER PRACTICAL CONSTRAINTS MAY UNDERMINE THE PERCEIVED ACCESS TO THE PRACTICE FOR MEMBERS OF DIVERSE GROUPS. WE CONCLUDE WITH INVITING FUTURE CONSIDERATIONS TOWARDS FOSTERING MORE INTERDISCIPLINARY COMMUNITY-BASED RESEARCH PARTNERSHIPS AMONG THE VARIETY OF STAKEHOLDERS INVESTED IN ADVANCING THE ACCESSIBILITY AND INCLUSION OF YOGA AND POSITIVE EMBODIMENT FOR ALL BODIES. 2020