1 1599 92 MEDITATIVE STATES BASED ON YOGA TEXTS AND THEIR EFFECTS ON PERFORMANCE OF A LETTER-CANCELLATION TASK. PERFORMANCE IN A SIX-LETTER CANCELLATION TASK WAS STUDIED IN 35 MALE EXPERIENCED MEDITATORS WITH EXPERIENCE RANGING FROM 6 TO 12 MONTHS. EACH PARTICIPANT WAS STUDIED IN FOUR SESSIONS, TWO MEDITATION AND TWO CONTROL SESSIONS. THE CONTROL SESSIONS WERE (I) CANCALATA OR NONTARGETED THINKING AND (II) EKAGRATA OR FOCUSING ON A SINGLE TOPIC, IN THIS CASE, MEDITATION. THE MEDITATION SESSIONS WERE (I) DHARANA OR FOCUSING ON THE SYMBOL "OM" AND (II) DHYANA OR AN EFFORTLESS SINGLE-THOUGHT (OF OM) STATE. EKAGRATA AND DHARANA DIFFER IN THAT THE FORMER INVOLVES FOCUSING WITH MULTIPLE THOUGHTS WHEREAS THE LATTER INVOLVES FOCUSING WITH A SINGLE THOUGHT, I.E., THE SIGNIFICANCE OF OM. THE NET SCORES ON THE SIX-LETTER CANCELLATION TASK WERE SIGNIFICANTLY HIGHER AFTER A SESSION OF DHARANA AND LOWER AFTER THE CANCALATA SESSION, WHILE THERE WAS NO SIGNIFICANT CHANGE AFTER EKAGRATA AND DHYANA SESSIONS. FOCUSING ON THE SYMBOL OM IN DHARANA MAY FAVORABLY INFLUENCE SELECTIVE ATTENTION, CONCENTRATION, VISUAL SCANNING ABILITIES, AND A REPETITIVE MOTOR RESPONSE COMPARED TO OTHER SESSIONS.	2009	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
2 1191 32 EVOLUTION FROM FOUR MENTAL STATES TO THE HIGHEST STATE OF CONSCIOUSNESS: A NEUROPHYSIOLOGICAL BASIS OF MEDITATION AS DEFINED IN YOGA TEXTS. THIS CHAPTER PROVIDES A THEORETICAL INTRODUCTION TO STATES OF CONSCIOUSNESS AND REVIEWS NEUROSCIENTIFIC INVESTIGATIONS OF MEDITATION. THE DIFFERENT STATES OF CONSCIOUSNESS CONSIST OF FOUR MENTAL STATES, I.E., CANCALATA (RANDOM THINKING), EKAGRATA (NON-MEDITATIVE FOCUSING), DHARNA (FOCUSED MEDITATION), AND DHYANA (MEDITATION) AS DEFINED IN YOGA TEXTS. MEDITATION IS A SELF-REGULATED MENTAL PROCESS ASSOCIATED WITH DEEP RELAXATION AND INCREASED INTERNALIZED ATTENTION. SCIENTIFIC INVESTIGATIONS ON MEDITATION REPORTED CHANGES IN ELECTROPHYSIOLOGICAL SIGNALS AND NEUROIMAGING MEASURES. BUT MOST OUTCOMES OF MEDITATION STUDIES SHOWED INCONSISTENT RESULTS, THIS MAY BE DUE TO HETEROGENEITY IN MEDITATION METHODS AND TECHNIQUES EVOLVED IN THE LAST 200 YEARS. TRADITIONALLY, THE FEATURES OF MEDITATION INCLUDE THE CAPACITY TO SUSTAIN A HEIGHTENED AWARENESS OF THOUGHTS, BEHAVIORS, EMOTIONS, AND PERCEPTIONS. GENERALLY, MEDITATION INVOLVES NON-REACTIVE EFFORTLESS MONITORING OF THE CONTENT OF EXPERIENCE FROM MOMENT TO MOMENT. FOCUSED MEDITATION PRACTICE INVOLVES AWARENESS ON A SINGLE OBJECT AND OPEN MONITORING MEDITATION IS A NON-DIRECTIVE MEDITATION INVOLVED ATTENTION IN BREATHING, MANTRA, OR SOUND. THEREFORE, RESULTS OF FEW EMPIRICAL STUDIES OF ADVANCED MEDITATORS OR BEGINNERS REMAIN TENTATIVE. THIS IS AN ATTEMPT TO COMPILE THE MEDITATION-RELATED CHANGES IN ELECTROPHYSIOLOGICAL AND NEUROIMAGING PROCESSES AMONG EXPERIENCED AND NOVICE PRACTITIONERS.	2019	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
3  448 38 CHANGES IN AUTONOMIC VARIABLES FOLLOWING TWO MEDITATIVE STATES DESCRIBED IN YOGA TEXTS. OBJECTIVES: IN ANCIENT YOGA TEXTS THERE ARE TWO MEDITATIVE STATES DESCRIBED. ONE IS DHARANA, WHICH REQUIRES FOCUSING, THE SECOND IS DHYANA, DURING WHICH THERE IS NO FOCUSING, BUT AN EXPANSIVE MENTAL STATE IS REACHED. WHILE AN EARLIER STUDY DID SHOW IMPROVED PERFORMANCE IN AN ATTENTION TASK AFTER DHARANA, THE AUTONOMIC CHANGES DURING THESE TWO STATES HAVE NOT BEEN STUDIED. METHODS: AUTONOMIC AND RESPIRATORY VARIABLES WERE ASSESSED IN 30 HEALTHY MALE VOLUNTEERS (GROUP MEAN AGE +/- SD, 29.1 +/- 5.1 YEARS) DURING FOUR MENTAL STATES DESCRIBED IN TRADITIONAL YOGA TEXTS. THESE FOUR MENTAL STATES ARE RANDOM THINKING (CANCALATA), NONMEDITATIVE FOCUSING (EKAGRATA), MEDITATIVE FOCUSING (DHARANA), AND EFFORTLESS MEDITATION (DHYANA). ASSESSMENTS WERE MADE BEFORE (5 MINUTES), DURING (20 MINUTES), AND AFTER (5 MINUTES), EACH OF THE FOUR STATES, ON FOUR SEPARATE DAYS. RESULTS: DURING DHYANA THERE WAS A SIGNIFICANT INCREASE IN THE SKIN RESISTANCE LEVEL (P<0.001; POST HOC ANALYSIS FOLLOWING ANOVA, DURING COMPARED TO PRE) AND PHOTO-PLETHYSMOGRAM AMPLITUDE (P<0.05), WHEREAS THERE WAS A SIGNIFICANT DECREASE IN THE HEART RATE (P<0.001) AND BREATH RATE (P<0.001). THERE WAS A SIGNIFICANT DECREASE IN THE LOW FREQUENCY (LF) POWER (P<0.001) AND INCREASE IN THE HIGH FREQUENCY (HF) POWER (P<0.001) IN THE FREQUENCY DOMAIN ANALYSIS OF THE HEART RATE VARIABILITY (HRV) SPECTRUM, ON WHICH HF POWER IS ASSOCIATED WITH PARASYMPATHETIC ACTIVITY. THERE WAS ALSO A SIGNIFICANT INCREASE IN THE NN50 COUNT (THE NUMBER OF INTERVAL DIFFERENCES OF SUCCESSIVE NN INTERVALS GREATER THAN 50 MS; P<0.001) AND THE PNN50 (THE PROPORTION DERIVED BY DIVIDING NN50 BY THE TOTAL NUMBER OF NN INTERVALS; P<0.001) IN TIME DOMAIN ANALYSIS OF HRV, BOTH INDICATIVE OF PARASYMPATHETIC ACTIVITY. CONCLUSIONS: MAXIMUM CHANGES WERE SEEN IN AUTONOMIC VARIABLES AND BREATH RATE DURING THE STATE OF EFFORTLESS MEDITATION (DHYANA). THE CHANGES WERE ALL SUGGESTIVE OF REDUCED SYMPATHETIC ACTIVITY AND/OR INCREASED VAGAL MODULATION. DURING DHARANA THERE WAS AN INCREASE IN SKIN RESISTANCE. THE CHANGES IN HRV DURING EKAGRATA AND CANCALATA WERE INCONCLUSIVE.	2013	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
4 2407 17 YOGA AND HEALTH. YOGA HAS BEEN THE SUBJECT OF RESEARCH IN THE PAST FEW DECADES FOR THERAPEUTIC PURPOSES FOR MODERN EPIDEMIC DISEASES LIKE MENTAL STRESS, OBESITY, DIABETES, HYPERTENSION, CORONARY HEART DISEASE, AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE. INDIVIDUAL STUDIES REPORT BENEFICIAL EFFECT OF YOGA IN THESE CONDITIONS, INDICATING THAT IT CAN BE USED AS NONPHARMACEUTICAL MEASURE OR COMPLEMENT TO DRUG THERAPY FOR TREATMENT OF THESE CONDITIONS. HOWEVER, THESE STUDIES HAVE USED ONLY YOGA ASANA, PRANAYAMA, AND/ OR SHORT PERIODS OF MEDITATION FOR THERAPEUTIC PURPOSES. GENERAL PERCEPTION ABOUT YOGA IS ALSO THE SAME, WHICH IS NOT CORRECT. YOGA IN FACT MEANS UNION OF INDIVIDUAL CONSCIOUSNESS WITH THE SUPREME CONSCIOUSNESS. IT INVOLVES EIGHT RUNGS OR LIMBS OF YOGA, WHICH INCLUDE YAMA, NIYAMA, ASANA, PRANAYAMA, PRATYAHARA, DHARANA, DHYANA, AND SAMADHI. INTENSE PRACTICE OF THESE LEADS TO SELF-REALIZATION, WHICH IS THE PRIMARY GOAL OF YOGA. AN ANALYTICAL LOOK AT THE RUNGS AND THE GOAL OF YOGA SHOWS THAT IT IS A HOLISTIC WAY OF LIFE LEADING TO A STATE OF COMPLETE PHYSICAL, SOCIAL, MENTAL, AND SPIRITUAL WELL-BEING AND HARMONY WITH NATURE. THIS IS IN CONTRAST TO PURELY ECONOMIC AND MATERIAL DEVELOPMENTAL GOAL OF MODERN CIVILIZATION, WHICH HAS BROUGHT SOCIAL UNREST AND ECOLOGICAL DEVASTATION.	2014	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
5 2564 19 YOGA FOR CONTROL OF EPILEPSY. YOGA IS AN AGE-OLD TRADITIONAL INDIAN PSYCHO-PHILOSOPHICAL-CULTURAL METHOD OF LEADING ONE'S LIFE, THAT ALLEVIATES STRESS, INDUCES RELAXATION AND PROVIDES MULTIPLE HEALTH BENEFITS TO THE PERSON FOLLOWING ITS SYSTEM. IT IS A METHOD OF CONTROLLING THE MIND THROUGH THE UNION OF AN INDIVIDUAL'S DORMANT ENERGY WITH THE UNIVERSAL ENERGY. COMMONLY PRACTICED YOGA METHODS ARE 'PRANAYAMA' (CONTROLLED DEEP BREATHING), 'ASANAS' (PHYSICAL POSTURES) AND 'DHYANA' (MEDITATION) ADMIXED IN VARYING PROPORTIONS WITH DIFFERING PHILOSOPHIC IDEAS. A REVIEW OF YOGA IN RELATION TO EPILEPSY ENCOMPASSES NOT ONLY SEIZURE CONTROL BUT ALSO MANY FACTORS DEALING WITH OVERALL QUALITY-OF-LIFE ISSUES (QOL). THIS PAPER REVIEWS ARTICLES RELATED TO YOGA AND EPILEPSY, SEIZURES, EEG, AUTONOMIC CHANGES, NEURO-PSYCHOLOGY, LIMBIC SYSTEM, AROUSAL, SLEEP, BRAIN PLASTICITY, MOTOR PERFORMANCE, BRAIN IMAGING STUDIES, AND REHABILITATION. THERE IS A DEARTH OF RANDOMIZED, BLINDED, CONTROLLED STUDIES RELATED TO YOGA AND SEIZURE CONTROL. A MULTI-CENTRE, CROSS-CULTURAL, PREFERABLY BLINDED (DIFFICULT FOR YOGA), WELL-RANDOMIZED CONTROLLED TRIAL, ESPECIALLY USING A SINGLE YOGIC TECHNIQUE IN A HOMOGENEOUS POPULATION SUCH AS JUVENILE MYOCLONIC EPILEPSY IS JUSTIFIED TO FIND OUT HOW YOGA AFFECTS SEIZURE CONTROL AND QOL OF THE PERSON WITH EPILEPSY.	2001	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
6  613 19 DEVELOPMENT OF A YOGA PROGRAM FOR TYPE-2 DIABETES PREVENTION (YOGA-DP) AMONG HIGH-RISK PEOPLE IN INDIA. INTRODUCTION: MANY INDIANS ARE AT HIGH-RISK OF TYPE-2 DIABETES MELLITUS (T2DM). YOGA IS AN ANCIENT INDIAN MIND-BODY DISCIPLINE, THAT HAS BEEN ASSOCIATED WITH IMPROVED GLUCOSE LEVELS AND CAN HELP TO PREVENT T2DM. THE STUDY AIMED TO SYSTEMATICALLY DEVELOP A YOGA PROGRAM FOR T2DM PREVENTION (YOGA-DP) AMONG HIGH-RISK PEOPLE IN INDIA USING A COMPLEX INTERVENTION DEVELOPMENT APPROACH. MATERIALS AND METHODS: AS PART OF THE INTERVENTION, WE DEVELOPED A BOOKLET AND A HIGH-DEFINITION VIDEO FOR PARTICIPANTS AND A MANUAL FOR YOGA-DP INSTRUCTORS. A SYSTEMATIC ITERATIVE PROCESS WAS FOLLOWED TO DEVELOP THE INTERVENTION AND INCLUDED FIVE STEPS: (I) A SYSTEMATIC REVIEW OF THE LITERATURE TO GENERATE A LIST OF YOGIC PRACTICES THAT IMPROVES BLOOD GLUCOSE LEVELS AMONG ADULTS AT HIGH-RISK OF OR WITH T2DM, (II) VALIDATION OF IDENTIFIED YOGIC PRACTICES BY YOGA EXPERTS, (III) DEVELOPMENT OF THE INTERVENTION, (IV) CONSULTATION WITH YOGA, EXERCISE, PHYSICAL ACTIVITY, DIET, BEHAVIOR CHANGE, AND/OR DIABETES EXPERTS ABOUT THE INTERVENTION, AND (V) PRETEST THE INTERVENTION AMONG YOGA PRACTITIONERS AND LAY PEOPLE (THOSE AT RISK OF T2DM AND HAD NOT PRACTICED YOGA BEFORE) IN INDIA. RESULTS: YOGA-DP IS A STRUCTURED LIFESTYLE EDUCATION AND EXERCISE PROGRAM, PROVIDED OVER A PERIOD OF 24 WEEKS. THE EXERCISE PART IS BASED ON YOGA AND INCLUDES SHITHILIKARANA VYAYAMA (LOOSENING EXERCISES), SURYA NAMASKAR (SUN SALUTATION EXERCISES), ASANA (YOGIC POSES), PRANAYAMA (BREATHING PRACTICES), AND DHYANA (MEDITATION) AND RELAXATION PRACTICES. ONCE PARTICIPANTS COMPLETE THE PROGRAM, THEY ARE STRONGLY ENCOURAGED TO MAINTAIN A HEALTHY LIFESTYLE IN THE LONG-TERM. CONCLUSIONS: WE SYSTEMATICALLY DEVELOPED A NOVEL YOGA PROGRAM FOR T2DM PREVENTION (YOGA-DP) AMONG HIGH-RISK PEOPLE IN INDIA. A MULTI-CENTER FEASIBILITY RANDOMIZED CONTROLLED TRIAL IS IN PROGRESS IN INDIA.	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
7 1927 15 ROLE OF YOGA IN CARDIAC DISEASE AND REHABILITATION. PURPOSE: CARDIOVASCULAR DISEASE CONTINUES TO BE THE LEADING CAUSE OF MORBIDITY AND MORTALITY AROUND THE WORLD. YOGA, A COMBINATION OF PHYSICAL POSTURES (ASANA), BREATHING EXERCISES (PRANAYAMA), AND MEDITATION (DHYANA), HAS GAINED INCREASING RECOGNITION AS A FORM OF MIND-BODY EXERCISE. IN THIS NARRATIVE REVIEW, WE INTENDED TO REVIEW THE EMERGING EVIDENCE ASSESSING THE PHYSIOLOGIC AND CLINICAL EFFECTS OF YOGA ON THE CARDIOVASCULAR SYSTEM AND THE POTENTIAL ROLE OF YOGA AS A COMPONENT OF COMPREHENSIVE CARDIAC REHABILITATION. METHODS: WE SEARCHED PUBMED, GOOGLE SCHOLAR, EMBASE, AND COCHRANE DATABASES FOR LITERATURE RELATED TO CARDIOVASCULAR EFFECTS OF YOGA FROM INCEPTION UP UNTIL 2017. RESULTS: YOGA HAS BEEN SHOWN TO HAVE FAVORABLE EFFECTS ON SYSTEMIC INFLAMMATION, STRESS, THE CARDIAC AUTONOMIC NERVOUS SYSTEM, AND TRADITIONAL AND EMERGING CARDIOVASCULAR RISK FACTORS. CONCLUSIONS: YOGA HAS SHOWN PROMISE AS A USEFUL LIFESTYLE INTERVENTION THAT CAN BE INCORPORATED INTO CARDIOVASCULAR DISEASE MANAGEMENT ALGORITHMS. ALTHOUGH MANY INVESTIGATORS HAVE REPORTED THE CLINICAL BENEFITS OF YOGA IN REDUCING CARDIOVASCULAR EVENTS, MORBIDITY, AND MORTALITY, EVIDENCE SUPPORTING THESE CONCLUSIONS IS SOMEWHAT LIMITED, THEREBY EMPHASIZING THE NEED FOR LARGE, WELL-DESIGNED RANDOMIZED TRIALS THAT MINIMIZE BIAS AND METHODOLOGICAL DRAWBACKS.	2019	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
8 2418 23 YOGA AND MENOPAUSAL TRANSITION. WITH INCREASED LIFE EXPECTANCY, TODAY, WOMEN SPEND ONE-THIRD OF THEIR LIFE AFTER MENOPAUSE. THUS MORE ATTENTION IS NEEDED TOWARDS PERI- AND POST-MENOPAUSAL SYMPTOMS. ESTROGEN REPLACEMENT THERAPY IS THE MOST EFFECTIVE TREATMENT, HOWEVER, IT HAS ITS OWN LIMITATIONS. THE PRESENT NEED IS TO EXPLORE NEW OPTIONS FOR THE MANAGEMENT OF MENOPAUSAL SYMPTOMS. YOGIC LIFE STYLE IS A WAY OF LIVING WHICH AIMS TO IMPROVE THE BODY, MIND AND DAY TO DAY LIFE OF INDIVIDUALS. THE MOST COMMONLY PERFORMED YOGA PRACTICES ARE POSTURES (ASANA), CONTROLLED BREATHING (PRANAYAMA), AND MEDITATION (DHYANA). YOGA HAS BEEN UTILIZED AS A THERAPEUTIC TOOL TO ACHIEVE POSITIVE HEALTH AND CONTROL AND CURE DISEASES. THE EXACT MECHANISM AS TO HOW YOGA HELPS IN VARIOUS DISEASE STATES IS NOT KNOWN. THERE COULD BE NEURO-HORMONAL PATHWAYS WITH A SELECTIVE EFFECT IN EACH PATHOLOGICAL SITUATION. THERE HAVE BEEN MULTIPLE STUDIES THAT HAVE COMBINED THE MANY ASPECTS OF YOGA INTO A GENERAL YOGA SESSION IN ORDER TO INVESTIGATE ITS EFFECTS ON MENOPAUSAL SYMPTOMS. INTEGRATED APPROACH OF YOGA THERAPY CAN IMPROVE HOT FLUSHES AND NIGHT SWEATS. THERE IS INCREASING EVIDENCE SUGGESTING THAT EVEN THE SHORT-TERM PRACTICE OF YOGA CAN DECREASE BOTH PSYCHOLOGICAL AND PHYSIOLOGICAL RISK FACTORS FOR CARDIOVASCULAR DISEASE (CVD). STUDIES CONCLUDE THAT OUR AGE OLD THERAPY, YOGA, IS FAIRLY EFFECTIVE IN MANAGING MENOPAUSAL SYMPTOMS.	2010	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
9  600 19 DEVELOPMENT AND VALIDATION OF 20-MIN YOGA MODULE FOR REDUCING BURNOUT AMONG HEALTHCARE WORKER(S). BACKGROUND: A HIGH PREVALENCE OF BURNOUT HAS BEEN REPORTED AMONG HEALTHCARE WORKER(S). DURING THE CURRENT PANDEMIC, SUCH BURNOUT HAS INCREASED DUE TO EXCESSIVE LOAD OF PATIENT CARE, USE OF PERSONAL PROTECTIVE EQUIPMENT (PPE) KITS, WORKING IN LONG SHIFTS, STAYING AWAY FROM FAMILY DUE TO ISOLATION NORMS, AND DISRUPTED SOCIAL LIFE. EXISTING YOGA TECHNIQUES USED FOR REDUCING BURNOUT INCLUDE 45 MIN TO HOUR-LONG SESSIONS, WHICH MAY NOT BE FEASIBLE FOR REGULAR PRACTICE BY THE HEALTHCARE WORKER(S). OBJECTIVE: THE PROPOSED STUDY AIMED TO DEVELOP A 20-MIN YOGA MODULE TO REDUCE BURNOUT AMONG HEALTHCARE WORKER(S). METHODS: TO DEVELOP A 20-MIN YOGA MODULE, WE REVIEWED YOGA TEXTS AND RELEVANT SCIENTIFIC RESEARCH ARTICLES. COMPONENTS OF THE 20-MIN YOGA MODULE INCLUDE SUKSHMA VYAYAMA (LOOSENING EXERCISES), PRANAYAMA (REGULATED BREATHING), AND DHYANA (MEDITATION). NINETEEN YOGA EXPERTS VALIDATED THE 20-MIN YOGA MODULE WITH AN AVERAGE (SD) OF 11.47 (6.77) YEARS OF RESEARCH AND CLINICAL EXPERIENCE IN YOGA. CONTENT VALIDITY RATIO (CVR) WAS CALCULATED ACCORDING TO LAWSHE'S METHOD. ITEMS HAVING A CVR OF 0.47 AND ABOVE WERE RETAINED IN THE MODULE. RESULTS AND CONCLUSION: THE CONTENT VALIDITY INDEX (CVI) OF THE ENTIRE MODULE WAS 0.83. CVR RESULTS OF THE ELEMENTS OF THE 20-MIN YOGA MODULE INDICATED THAT EXPERTS CONSIDER THESE PRACTICES TO BE ESSENTIAL FOR REDUCING BURNOUT AMONG THE HEALTHCARE WORKER(S). THE STRENGTH OF THE 20-MIN YOGA MODULE LIES IN ITS SHORT DURATION AND EASY-TO-LEARN PRACTICES. 20-MIN YOGA MODULE CAN BE IMPLEMENTED IN PRACTICE BY THE HEALTHCARE WORKER(S) FOR REDUCING BURNOUT FOLLOWING EFFICACY STUDIES THROUGH FURTHER CLINICAL TRIALS.	2022	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
10 2443 19 YOGA AND SEXUAL FUNCTIONING: A REVIEW. YOGA IS AN ANCIENT PRACTICE WITH EASTERN ROOTS THAT INVOLVES BOTH PHYSICAL POSTURES (ASANAS) AND BREATHING TECHNIQUES (PRANAYAMAS). THERE IS ALSO A COGNITIVE COMPONENT FOCUSING ON MEDITATION AND CONCENTRATION, WHICH AIDS IN ACHIEVING THE GOAL OF UNION BETWEEN THE SELF AND THE SPIRITUAL. ALTHOUGH NUMEROUS EMPIRICAL STUDIES HAVE FOUND A BENEFICIAL EFFECT OF YOGA ON DIFFERENT ASPECTS OF PHYSICAL AND PSYCHOLOGICAL FUNCTIONING, CLAIMS OF YOGA'S BENEFICIAL EFFECTS ON SEXUALITY DERIVE FROM A RICH BUT NONEMPIRICAL LITERATURE. THE GOAL OF THIS ARTICLE IS TO REVIEW THE PHILOSOPHY AND FORMS OF YOGA, TO REVIEW THE NONEMPIRICAL AND (LIMITED) EMPIRICAL LITERATURES LINKING YOGA WITH ENHANCED SEXUALITY, AND TO PROPOSE SOME FUTURE RESEARCH AVENUES FOCUSINGING ON YOGA AS A TREATMENT FOR SEXUAL COMPLAINTS.	2009	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
11 2061 20 THE BENEFITS OF YOGA IN CHILDREN. THE NUMBER OF CHILDREN SUFFERING FROM STRESS AND ANXIETY IN MALAYSIA IS ON THE RISE. EVIDENCE SHOWS THAT MIND-BODY THERAPIES SUCH AS MINDFULNESS THERAPY, MEDITATION AND YOGA HAVE BEEN PRACTICED IN MANY OTHER COUNTRIES TO REDUCE AND/OR MANAGE THE PSYCHOLOGICAL EFFECTS OF STRESS AND ANXIETY. THIS REVIEW ARTICLE LOOKS AT THE INTERVENTION OF YOGA AS A MEDITATIVE MOVEMENT PRACTICE IN HELPING SCHOOL CHILDREN MANAGE STRESS AND ANXIETY. ARTICLES WERE RETRIEVED USING A COMBINATION OF DATABASES INCLUDING PUBMED/MEDLINE, AND PSYCINFO. NOT ONLY PEER-REVIEWED ARTICLES, BUT ALSO THOSE WRITTEN IN ENGLISH LANGUAGE WERE INCLUDED IN THIS REVIEW. ALL STUDIES REVIEWED HAD INCORPORATED SOME FORM OF MEDITATIVE MOVEMENT EXERCISE. THE INTERVENTION ENCOMPASSED ASANAS (POSTURES), PRANAYAMA (EXPANSION OF LIFE FORCE), DHARANA (CONCENTRATION) AND DHYANA (MEDITATION), WHICH ARE THE DIFFERENT PATHS IN YOGA. A TOTAL OF EIGHT ARTICLES MET THE INCLUSION CRITERIA AND WERE REVIEWED. THE FINDINGS OF THIS REVIEW REVEAL THAT THE PRACTICE OF YOGA HAS BROUGHT ABOUT, AMONG OTHER THINGS, IMPROVEMENT IN MANAGING AND REDUCING STRESS AND ANXIETY. DESPITE THE LIMITATIONS IN MOST, IF NOT ALL OF THE STUDIES REVIEWED, IN TERMS OF HETEROGENEITY AND SAMPLE SIZE, YOGA APPEARS TO BE AN EFFECTIVE MODALITY FOR HELPING CHILDREN COPE WITH STRESS AND ANXIETY. IT APPEARS THAT IF SCHOOLS IN MALAYSIA CAN INCORPORATE YOGA AS PART OF THE PHYSICAL EDUCATION CURRICULUM, IT WILL DEFINITELY BENEFIT THE STUDENTS.	2018	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
12 1951 15 SCIENCE OF THE MIND: ANCIENT YOGA TEXTS AND MODERN STUDIES. THE PRACTICE OF YOGA IS GAINING IN POPULARITY WITH A WIDE RANGE OF PRACTICES. RECENT RESEARCH AND DESCRIPTIONS FROM THE ANCIENT TEXTS ARE OFTEN CONCURRENT WITH REGARD TO THE EFFECTS OF THE PRACTICE, TAKING INTO ACCOUNT EXPECTED DIFFERENCES BETWEEN MODERN SCIENTIFIC TERMS AND THOSE USED IN THE ORIGINAL TEXTS. VOLUNTARILY REGULATED YOGA BREATHING PRACTICES FORM A BRIDGE BETWEEN PHYSICAL AND MENTAL CHANGES. THE VOLUNTARILY REGULATED YOGA BREATHING HAS DISTINCT EFFECTS ON METABOLISM, THE AUTONOMIC NERVOUS SYSTEM, HIGHER BRAIN FUNCTIONS, AND MENTAL STATE. THE EFFECTS OF MEDITATION ON THE NERVOUS SYSTEM AND MENTAL STATE ARE EVEN CLEARER.	2013	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
13 2764 24 YOGA PROGRAMME FOR TYPE-2 DIABETES PREVENTION (YOGA-DP) AMONG HIGH RISK PEOPLE IN INDIA: A MULTICENTRE FEASIBILITY RANDOMISED CONTROLLED TRIAL PROTOCOL. INTRODUCTION: A HUGE POPULATION IN INDIA IS AT HIGH RISK OF TYPE-2 DIABETES (T2DM). PHYSICAL ACTIVITY AND A HEALTHY DIET (HEALTHY LIFESTYLE) IMPROVE BLOOD GLUCOSE LEVELS IN PEOPLE AT HIGH RISK OF T2DM. HOWEVER, AN UNHEALTHY LIFESTYLE IS COMMON AMONG INDIANS. YOGA COVERS PHYSICAL ACTIVITY AND A HEALTHY DIET AND CAN HELP TO PREVENT T2DM. THE RESEARCH QUESTION TO BE ADDRESSED BY THE MAIN RANDOMISED CONTROLLED TRIAL (RCT) IS WHETHER A YOGA PROGRAMME FOR T2DM PREVENTION (YOGA-DP) IS EFFECTIVE IN PREVENTING T2DM AMONG HIGH RISK PEOPLE IN INDIA AS COMPARED WITH ENHANCED STANDARD CARE. IN THIS CURRENT STUDY, WE ARE DETERMINING THE FEASIBILITY OF UNDERTAKING THE MAIN RCT. INTERVENTION: YOGA-DP IS A STRUCTURED LIFESTYLE EDUCATION AND EXERCISE PROGRAMME. THE EXERCISE PART IS BASED ON YOGA AND INCLUDES SHITHILIKARANA VYAYAMA (LOOSENING EXERCISES), SURYA NAMASKAR (SUN SALUTATION EXERCISES), ASANA (YOGIC POSES), PRANAYAMA (BREATHING PRACTICES) AND DHYANA (MEDITATION) AND RELAXATION PRACTICES. METHODS AND ANALYSIS: THIS IS A MULTICENTRE, TWO-ARM, PARALLEL-GROUP, FEASIBILITY RCT WITH BLINDED OUTCOME ASSESSMENT AND INTEGRATED MIXED-METHODS PROCESS EVALUATION. ELIGIBLE PARTICIPANTS SHOULD BE AGED 18-74 YEARS, AT HIGH RISK OF T2DM (FASTING PLASMA GLUCOSE LEVEL 5.6-6.9 MMOL/L) AND SAFE TO PARTICIPATE IN PHYSICAL ACTIVITIES. AT LEAST 64 PARTICIPANTS WILL BE RANDOMISED TO INTERVENTION OR CONTROL GROUP WITH FINAL FOLLOW-UP AT 6 MONTHS. IMPORTANT PARAMETERS, NEEDED TO DESIGN THE MAIN RCT, WILL BE ESTIMATED, SUCH AS SD OF THE OUTCOME MEASURE (FASTING PLASMA GLUCOSE LEVEL AT 6-MONTH FOLLOW-UP), RECRUITMENT, INTERVENTION ADHERENCE, FOLLOW-UP, POTENTIAL CONTAMINATION AND TIME NEEDED TO CONDUCT THE STUDY. SEMISTRUCTURED QUALITATIVE INTERVIEWS WILL BE CONDUCTED WITH UP TO 20-30 PARTICIPANTS, A SAMPLE OF THOSE DECLINING TO PARTICIPATE, FOUR YOGA-DP INSTRUCTORS AND AROUND EIGHT STUDY STAFF TO EXPLORE THEIR PERCEPTIONS AND EXPERIENCES OF TAKING PART IN THE STUDY AND OF THE INTERVENTION, REASONS BEHIND NON-PARTICIPATION, EXPERIENCES OF DELIVERING THE INTERVENTION AND RUNNING THE STUDY, RESPECTIVELY. ETHICS AND DISSEMINATION: ETHICS APPROVAL HAS BEEN OBTAINED FROM THE FOLLOWING RESEARCH ETHICS COMMITTEES: FACULTY OF MEDICINE AND HEALTH SCIENCES, UNIVERSITY OF NOTTINGHAM (UK); CENTRE FOR CHRONIC DISEASE CONTROL (CCDC, INDIA); BAPU NATURE CURE HOSPITAL AND YOGASHRAM (BNCHY, INDIA) AND SWAMI VIVEKANANDA YOGA ANUSANDHANA SAMSTHANA (S-VYASA, INDIA). THE RESULTS WILL BE WIDELY DISSEMINATED AMONG KEY STAKEHOLDERS THROUGH VARIOUS AVENUES. TRIAL REGISTRATION NUMBER: CTRI/2019/05/018893.	2020	

14 1934 11 ROLE OF YOGA IN STRESS MANAGEMENT. THE STATE OF THE MIND AND THAT OF THE BODY ARE INTIMATELY RELATED. IF THE MIND IS RELAXED, THE MUSCLES IN THE BODY WILL ALSO BE RELAXED. STRESS PRODUCES A STATE OF PHYSICAL AND MENTAL TENSION. YOGA, DEVELOPED THOUSANDS OF YEARS AGO, IS RECOGNIZED AS A FORM OF MIND-BODY MEDICINE. IN YOGA, PHYSICAL POSTURES AND BREATHING EXERCISES IMPROVE MUSCLE STRENGTH, FLEXIBILITY, BLOOD CIRCULATION AND OXYGEN UPTAKE AS WELL AS HORMONE FUNCTION. IN ADDITION, THE RELAXATION INDUCED BY MEDITATION HELPS TO STABILIZE THE AUTONOMIC NERVOUS SYSTEM WITH A TENDENCY TOWARDS PARASYMPATHETIC DOMINANCE. PHYSIOLOGICAL BENEFITS WHICH FOLLOW, HELP YOGA PRACTITIONERS BECOME MORE RESILIENT TO STRESSFUL CONDITIONS AND REDUCE A VARIETY OF IMPORTANT RISK FACTORS FOR VARIOUS DISEASES, ESPECIALLY CARDIO-RESPIRATORY DISEASES.	2004	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
15 1817 12 PROPOSED IDENTIFICATION OF PHYSIOLOGICAL CLASSIFICATION AND THEORETICAL MECHANISMS OF YOGASANAS. YOGA IN THE THEORETICAL AND PRACTICAL FORM IS NOW ACCEPTED ALL OVER THE WORLD, BY THE RESEARCHERS AS WELL AS BY THE GENERAL POPULATION. YOGASANA OR YOGIC POSTURES ARE ONE OF THE MAIN FOUNDATIONS OF PRACTICAL YOGA. MECHANISMS OF MEDIATION AND PRANAYAMA HAS ALREADY BEEN ESTABLISHED. IN THIS ARTICLE, THE AUTHOR IS FOR THE FIRST TIME PROPOSING PHYSIOLOGICAL CLASSIFICATION OF YOGASANA I.E. (A) STRETCH (B) CONTRACTION (C). NEUROMUSCULAR COORDINATION (D) SENSE REDUCTION (E) SPINE BRAIN ACTIVATION. IN SUPPORT OF THIS PHYSIOLOGICAL CLASSIFICATION AUTHOR HAS PROPOSED FIVE HYPOTHETICAL THEORIES I.E. (I) STRETCH RELAXATION AWARENESS (II) CONTRACTION RELAXATION AWARENESS (III) BALLASTIC CONTRACTION RELAXATION AWARENESS (IV) SENSORY MOTOR FUNCTION AWARENESS AND (V) VITAL ENERGY FLOW AWARENESS TO UNDERSTAND THE UNDERLYING MECHANISMS OF YOGASANA PRACTICE AND TO EXPLAIN ITS BENEFITS.	2021	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
16 1913 20 ROLE OF BREATHING EXERCISES IN ASTHMA-YOGA AND PRANAYAMA. ASTHMA IS A CHRONIC AIRWAY INFLAMMATORY DISEASE THAT RESULTS FROM A COMPLEX INTERPLAY OF GENETIC, ENVIRONMENTAL, AND LIFESTYLE FACTORS. THERE IS NO CURE FOR ASTHMA, AND THE MANAGEMENT IS USUALLY AS PER PUBLISHED GUIDELINES. AS IN MANY CHRONIC DISEASES CONDITIONS, VARIOUS ALTERNATIVE OR COMPLIMENTARY THERAPIES HAVE BEEN TRIED. OF THESE, YOGA AND PRANAYAMA HAVE GAINED WIDER ATTENTION IN RECENT YEARS. WHILE THE TERM YOGA IS A COMPLEX TERM ENCOMPASSING EIGHT LIMBS AS PER PATAMJAI IN THE YOGA SUTRAS, IN SIMPLE TERMS, YOGA IS DESCRIBED AS A COMBINATION OF 'ASANA' (PHYSICAL EXERCISES) AND 'PRANAYAMA' (BREATHING EXERCISE). THE TERM "ASTHMA" HAS BEEN DERIVED FROM THE GREEK WORD "PANTING,", WHICH INDICATES A RAPID AND SHALLOW BREATHING. THE MAIN AIM OF YOGA AND PRANAYAMA IN ASTHMA IS TO SYNCHRONIZE AND CONTROL BREATHING, THUS DECREASING HYPERVENTILATION. BESIDES THIS, THEY ALSO DECREASE THE STRESS/STRAIN/ANXIETY, CHANGE IN BEHAVIOR, BOOST IMMUNITY, AND IMPROVE STRENGTH/ENDURANCE OF RESPIRATORY MUSCLES THAT ARE HELPFUL IN ANY SUBJECT WITH ASTHMA. THERE HAVE BEEN A GOOD NUMBER OF STUDIES INCLUDING CLINICAL TRIALS IN CHILDREN WITH ASTHMA THAT HAVE FOUND SOME BENEFICIAL EFFECTS. IN THE PRESENT REVIEW, THE PHYSIOLOGY OF YOGA AND PRANAYAMA, RATIONALE FOR THEIR USE IN CHILDREN WITH ASTHMA ALONG WITH A SUMMARY OF VARIOUS STUDIES CONDUCTED TILL DATE, HAVE BEEN DISCUSSED. THESE ARE FOLLOWED BY RECOMMENDATIONS REGARDING THEIR INCORPORATION IN THE STANDARD OF CARE OF CHILDREN WITH ASTHMA.	2022	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
17  229 22 A SYSTEMATIC REVIEW OF THE ENERGY COST AND METABOLIC INTENSITY OF YOGA. PURPOSE: WITH THE INCREASING POPULARITY OF HATHA YOGA, IT IS IMPORTANT TO UNDERSTAND THE ENERGY COST AND METS OF YOGA PRACTICE WITHIN THE CONTEXT OF THE AMERICAN COLLEGE OF SPORTS MEDICINE (ACSM) AND THE AMERICAN HEART ASSOCIATION (AHA) PHYSICAL ACTIVITY GUIDELINES. METHODS: THIS SYSTEMATIC REVIEW EVALUATED THE ENERGY COST AND METABOLIC INTENSITY OF YOGA PRACTICE INCLUDING YOGA ASANAS (POSES/POSTURES) AND PRANAYAMAS (BREATH EXERCISES) MEASURED BY INDIRECT CALORIMETRY. THE ENGLISH-SPEAKING LITERATURE WAS SURVEYED VIA PUBMED USING THE GENERAL TERMS "YOGA" AND "ENERGY EXPENDITURE" WITH NO DATE LIMITATIONS. RESULTS: THIRTEEN MANUSCRIPTS WERE INITIALLY IDENTIFIED WITH AN ADDITIONAL FOUR LOCATED FROM REVIEW OF MANUSCRIPT REFERENCES. OF THE 17 STUDIES, 10 EVALUATED THE ENERGY COST AND METS OF FULL YOGA SESSIONS OR FLOW THROUGH SURYA NAMASKAR (SUN SALUTATIONS), EIGHT OF INDIVIDUAL ASANAS, AND FIVE OF PRANAYAMAS. METS FOR YOGA PRACTICE AVERAGED 3.3 +/- 1.6 (RANGE = 1.83-7.4 METS) AND 2.9 +/- 0.8 METS WHEN ONE OUTLIER (I.E., 7.4 METS FOR SURYA NAMASKAR) WAS OMITTED. METS FOR INDIVIDUAL ASANAS AVERAGED 2.2 +/- 0.7 (RANGE = 1.4-4.0 METS), WHEREAS THAT OF PRANAYAMAS WAS 1.3 +/- 0.3. ON THE BASIS OF ACSM/AHA CLASSIFICATION, THE INTENSITY OF MOST ASANAS AND FULL YOGA SESSIONS RANGED FROM LIGHT (LESS THAN 3 METS) TO MODERATE AEROBIC INTENSITY (3-6 METS), WITH THE MAJORITY CLASSIFIED AS LIGHT INTENSITY. CONCLUSION: THIS REVIEW SUGGESTS THAT YOGA IS TYPICALLY CLASSIFIED AS A LIGHT-INTENSITY PHYSICAL ACTIVITY. HOWEVER, A FEW SEQUENCES/POSES, INCLUDING SURYA NAMASKAR, MEET THE CRITERIA FOR MODERATE- TO VIGOROUS-INTENSITY ACTIVITY. IN ACCORDANCE WITH THE ACSM/AHA GUIDELINES, THE PRACTICE OF ASANA SEQUENCES WITH MET INTENSITIES HIGHER THAN THREE (I.E., >10 MIN) CAN BE ACCUMULATED THROUGHOUT THE DAY AND COUNT TOWARD DAILY RECOMMENDATIONS FOR MODERATE- OR VIGOROUS-INTENSITY PHYSICAL ACTIVITY.	2016	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
18 1590 12 MEDITATION AND YOGA CAN MODULATE BRAIN MECHANISMS THAT AFFECT BEHAVIOR AND ANXIETY-A MODERN SCIENTIFIC PERSPECTIVE. MEDITATION AND YOGA TECHNIQUES ARE RECEIVING INCREASED ATTENTION THROUGHOUT THE WORLD, DUE TO THE ACCUMULATION OF EVIDENCE BASED RESEARCH THAT PROVES THE DIRECT AND INDIRECT BENEFITS OF SUCH PRACTICES. BASED ON STUDIES CONDUCTED SO FAR, IT HAS BEEN FOUND THAT THE PRACTICE OF MEDITATION TRIGGERS NEUROTRANSMITTERS THAT MODULATE PSYCHOLOGICAL DISORDERS SUCH AS ANXIETY. THIS PAPER WILL REVIEW THE PSYCHOLOGICAL EFFECTS OF THE PRACTICE OF MEDITATION, THE ROLE OF NEUROTRANSMITTERS, AND STUDIES USING EEG AND FMRI.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
19 1561 15 LONGEVITY: POTENTIAL LIFE SPAN AND HEALTH SPAN ENHANCEMENT THROUGH PRACTICE OF THE BASIC YOGA MEDITATION REGIMEN. THIS CHAPTER BRIEFLY REVIEWS RECENT PSYCHOLOGICAL, PHYSIOLOGICAL, MOLECULAR BIOLOGICAL, AND ANTHROPOLOGICAL RESEARCH WHICH HAS IMPORTANT IMPLICATIONS, BOTH DIRECT AND INDIRECT, FOR THE RECOGNITION AND UNDERSTANDING OF THE POTENTIAL LIFE SPAN AND HEALTH SPAN ENHANCING EFFECTS OF THE BASIC YOGA MEDITATIONAL REGIMEN. THIS REGIMEN CONSISTS OF MEDITATION, YOGIC BREATH CONTROL PRACTICES, PHYSICAL EXERCISES (OF BOTH A POSTURAL- AND MOVEMENT-BASED, INCLUDING AEROBIC NATURE), AND DIETARY PRACTICES. WHILE EACH OF THESE COMPONENT CATEGORIES EXHIBIT VARIATIONS IN DIFFERENT SCHOOLS, LINEAGES, TRADITIONS, AND CULTURES, THE FOCUS OF THIS CHAPTER IS PRIMARILY ON BASIC FORMS OF RELAXATION MEDITATION AND BREATH CONTROL, AS WELL AS POSTURAL AND AEROBIC PHYSICAL EXERCISES (E.G., YOGIC PROSTRATION REGIMENS, SEE BELOW), AND A STANDARD FORM OF YOGIC OR ASCETIC DIET, ALL OF WHICH CONSTITUTE A BASIC FORM OF REGIMEN FOUND IN MANY IF NOT MOST CULTURES, THOUGH WITH VARIATIONS.	2009	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
20 1394 22 IMPACT OF YOGA BASED LIFESTYLE INTERVENTION ON PSYCHOLOGICAL STRESS AND QUALITY OF LIFE IN THE PARENTS OF CHILDREN WITH RETINOBLASTOMA. BACKGROUND: CHILDHOOD CANCERS ARE ASSOCIATED WITH A PSYCHOLOGICAL BURDEN TO THE PARENTS AND HENCE, DECLINE THEIR MENTAL AND PHYSICAL HEALTH AND OVERALL QUALITY OF LIFE. PURPOSE: THE PURPOSE OF THE PRESENT STUDY IS TO INVESTIGATE THE IMPACT OF 12-WEEKS YOGA BASED LIFESTYLE INTERVENTION ON PSYCHOLOGICAL STRESS AND QUALITY OF LIFE IN THE PARENTS OF CHILDREN AFFECTED WITH RETINOBLASTOMA. METHOD: SINGLE ARM PROSPECTIVE CLINICAL TRIAL CONDUCTED FROM OCTOBER 2015 TO OCTOBER 2017 AT THE LABORATORY FOR MOLECULAR REPRODUCTION AND GENETICS, DEPARTMENT OF ANATOMY, ALL INDIA INSTITUTE OF MEDICAL SCIENCES, NEW DELHI, INDIA. A PRE-TESTED 12-WEEKS YOGA BASED LIFESTYLE INTERVENTION INCLUDED ASANAS (PHYSICAL POSTURES), PRANAYAMA (BREATHING EXERCISES), DHYANA (MEDITATION), RELAXATION TECHNIQUES, LECTURES AND FILMS ON YOGA, INTERACTIVE SESSIONS AND INDIVIDUALIZED ADVICE WAS ADMINISTERED TO THE PARTICIPANTS. RESULTS: 12-WEEKS OF YOGA BASED LIFESTYLE INTERVENTION PROGRAMME LEADS TO A SIGNIFICANT IMPROVEMENT IN PSYCHOLOGICAL STRESS AND OVERALL QUALITY OF LIFE IN THE PARENTS OF RETINOBLASTOMA PATIENTS. THERE WAS A SIGNIFICANT IMPROVEMENT IN ALL THE DOMAINS (PHYSICAL HEALTH, PSYCHOLOGICAL HEALTH, SOCIAL RELATIONSHIPS, AND ENVIRONMENT) OF WHOQOL-BREF FROM BASELINE (DAY 0) TO 12-WEEKS OF YOGA BASED LIFESTYLE INTERVENTION. YOGA BASED LIFESTYLE INTERVENTION ALSO LED TO A SIGNIFICANT INCREASE IN THE LEVELS OF BRAIN DERIVED NEUROTROPHIC FACTOR, DEHYDROEPIANDROSTERONE SULPHATE, SIRTUIN 1 AND DECREASED THE CORTISOL AND IL-6 LEVELS. CONCLUSION: YOGA BASED LIFESTYLE INTERVENTION REDUCED THE SEVERITY OF PSYCHOLOGICAL STRESS AND RESULTED IN IMPROVEMENT IN OVERALL QUALITY OF LIFE AND UPREGULATION IN LEVELS OF SYSTEMIC BIOMARKERS OF NEUROPLASTICITY. YBLI MAY SERVE AS A BENEFICIAL THERAPY AND MAY ALSO ACT AS AN EFFECTIVE MEDIUM FOR BETTER STRESS MANAGEMENT TO DEVELOP BETTER COPING STRATEGIES IN THE PARENTS OF RETINOBLASTOMA PATIENTS.	2019