1 2886 125 YOGA: BALANCING THE EXCITATION-INHIBITION EQUILIBRIUM IN PSYCHIATRIC DISORDERS. SOCIAL BEHAVIORAL DISTURBANCES ARE CENTRAL TO MOST PSYCHIATRIC DISORDERS. A DISEQUILIBRIUM WITHIN THE CORTICAL EXCITATORY AND INHIBITORY NEUROTRANSMITTER SYSTEMS UNDERLIES THESE DEFICITS. GAMMA-AMINOBUTYRIC ACID (GABA) AND GLUTAMATE ARE THE MOST ABUNDANT EXCITATORY AND INHIBITORY NEUROTRANSMITTERS IN THE BRAIN THAT CONTRIBUTE TO THIS EQUILIBRIUM. SEVERAL CONTEMPORARY THERAPIES USED IN TREATING PSYCHIATRIC DISORDERS, REGULATE THIS GABA-GLUTAMATE BALANCE. YOGA HAS BEEN STUDIED AS AN ADJUVANT TREATMENT ACROSS A BROAD RANGE OF PSYCHIATRIC DISORDERS AND IS SHOWN TO HAVE SHORT-TERM THERAPEUTIC GAINS. EMERGING EVIDENCE FROM RECENT CLINICAL IN VIVO EXPERIMENTS SUGGESTS THAT YOGA IMPROVES GABA-MEDIATED CORTICAL-INHIBITORY TONE AND ENHANCES PERIPHERAL OXYTOCIN LEVELS. THIS IS LIKELY TO HAVE A MORE CONTROLLED DOWNSTREAM RESPONSE OF THE HYPOTHALAMO-PITUITARY-ADRENAL SYSTEM BY MEANS OF REDUCED CORTISOL RELEASE AND HENCE A BLUNTED SYMPATHETIC RESPONSE TO STRESS. ANIMAL AND EARLY FETAL DEVELOPMENTAL STUDIES SUGGEST AN INTER-DEPENDENT ROLE OF OXYTOCIN AND GABA IN REGULATING SOCIAL BEHAVIORS. IN KEEPING WITH THESE OBSERVATIONS, WE PROPOSE AN INTEGRATED NEUROBIOLOGICAL MODEL TO STUDY THE MECHANISMS OF THERAPEUTIC BENEFITS WITH YOGA. APART FROM PROVIDING A NEUROSCIENTIFIC BASIS FOR APPLYING A TRADITIONAL SYSTEM OF PRACTICE IN THE CLINICAL SETTING, THIS MODEL CAN BE USED AS A FRAMEWORK FOR STUDYING YOGA MECHANISMS IN FUTURE CLINICAL TRIALS. 2019 2 1639 32 MODULATION OF IMMUNE RESPONSES IN STRESS BY YOGA. STRESS IS A CONSTANT FACTOR IN TODAY'S FASTPACED LIFE THAT CAN JEOPARDIZE OUR HEALTH IF LEFT UNCHECKED. IT IS ONLY IN THE LAST HALF CENTURY THAT THE ROLE OF STRESS IN EVERY AILMENT FROM THE COMMON COLD TO AIDS HAS BEEN EMPHASIZED, AND THE MECHANISMS INVOLVED IN THIS PROCESS HAVE BEEN STUDIED. STRESS INFLUENCES THE IMMUNE RESPONSE PRESUMABLY THROUGH THE ACTIVATION OF THE HYPOTHALAMIC-PITUITARY ADRENAL AXIS, HYPOTHALAMIC PITUITARY-GONADAL AXIS, AND THE SYMPATHETIC-ADRENAL-MEDULLARY SYSTEM. VARIOUS NEUROTRANSMITTERS, NEUROPEPTIDES, HORMONES, AND CYTOKINES MEDIATE THESE COMPLEX BIDIRECTIONAL INTERACTIONS BETWEEN THE CENTRAL NERVOUS SYSTEM (CNS) AND THE IMMUNE SYSTEM. THE EFFECTS OF STRESS ON THE IMMUNE RESPONSES RESULT IN ALTERATIONS IN THE NUMBER OF IMMUNE CELLS AND CYTOKINE DYSREGULATION. VARIOUS STRESS MANAGEMENT STRATEGIES SUCH AS MEDITATION, YOGA, HYPNOSIS, AND MUSCLE RELAXATION HAVE BEEN SHOWN TO REDUCE THE PSYCHOLOGICAL AND PHYSIOLOGICAL EFFECTS OF STRESS IN CANCERS AND HIV INFECTION. THIS REVIEW AIMS TO DISCUSS THE EFFECT OF STRESS ON THE IMMUNE SYSTEM AND EXAMINE HOW RELAXATION TECHNIQUES SUCH AS YOGA AND MEDITATION COULD REGULATE THE CYTOKINE LEVELS AND HENCE, THE IMMUNE RESPONSES DURING STRESS. 2008 3 82 37 A MECHANISTIC MODEL FOR YOGA AS A PREVENTIVE AND THERAPEUTIC MODALITY. YOGA IS AN ANCIENT INDIAN TECHNIQUE OF HEALTHY LIVING. NUMEROUS STUDIES HAVE CORROBORATED YOGA'S BENEFICIAL EFFECTS, INCLUDING A FAVORABLE INFLUENCE ON AUTONOMIC FUNCTION AND NEGATIVE EMOTIONS. EXTENSIVE RESEARCH IN THE LAST FEW DECADES HAS REVEALED THE CRITICAL ROLE THAT YOGA CAN PLAY IN ERADICATING STRESS. THIS HAS LAID TO THE FOUNDATION FOR A SCIENTIFIC UNDERSTANDING OF PATHOPHYSIOLOGICAL CHANGES ATTRIBUTED TO STRESS, PARTICULARLY AT THE MOLECULAR AND GENETIC LEVELS. THIS PRIMARILY HAS HELPED UNDERSTAND THE EPIGENETIC AND GENETIC MECHANISM AT PLAY TO INDUCE AND ALLEVIATE STRESS, PARTICULARLY THOSE RELATED TO EMOTIONAL ABERRATIONS. AS RESEARCH HAS INDICATED, NEGATIVE EMOTIONS ARE TRANSLATED INTO VASCULAR INFLAMMATION APPROPRIATELY ACCENTUATED BY A SYMPATHETIC PREDOMINANT AUTONOMIC FUNCTION. THIS CASCADE IS BOLSTERED BY MULTIPLE FACTORS, INCLUDING ACTIVATION OF "STRESSOR" GENES AND ELABORATING HORMONES, INCLUDING STEROIDS WITH SOMETIMES NOCUOUS CONSEQUENCES, PARTICULARLY WHEN CHRONIC. YOGA HAS BEEN CATEGORICALLY FOUND TO HAVE INHIBITED EACH AND EVERY ONE OF THESE BANEFUL EFFECTS OF STRESS. IN FACT, IT ALSO CHANGES THE NEURONAL CIRCUITS THAT POTENTIATE SUCH A PLETHORA OF PATHOLOGICAL CHANGES. THIS, IN TURN, HAS ACCENTUATED YOGA'S RELEVANCE AS A POWERFUL PREVENTIVE INTERVENTION IN NONCOMMUNICABLE DISEASES (NCD). NCDS, INCLUDING HEART DISEASE, STROKE, AND RHEUMATOLOGICAL DISORDERS, ARE ESSENTIALLY INFLAMMATORY DISEASES THAT PERPETUATE INFLAMMATION IN DIFFERENT BEDS LIKE VASCULAR OR JOINT SPACES. THE PRECISE MECHANISM BY WHICH YOGA INDUCES SUCH BENEFICIAL CHANGES IS YET TO BE DELINEATED. HOWEVER, A CORNUCOPIA OF POINTERS INDICATES THAT NEURAL, ENDOCRINE, IMMUNOLOGICAL, CELLULAR, GENETIC, AND EPIGENETIC MECHANISMS ARE AT PLAY. THIS ARTICLE ATTEMPTS TO COBBLE TOGETHER NEWFANGLED RESEARCH TO DELINEATE A MEDICAL MODEL FOR THIS 5000-YEAR-OLD PRACTICE FROM INDIA. THIS IS IMPERATIVE, AS A MECHANISTIC MODEL OF THIS ANCIENT-BUT-COMPLEX SYSTEM WOULD ENABLE A MORE COMPREHENSIVE UNDERSTANDING OF ITS MECHANISM AND REVEAL ITS YET-UNDISCOVERED POSITIVE HEALTH EFFECTS. 2021 4 2608 23 YOGA FOR PSYCHIATRIC DISORDERS: FROM FAD TO EVIDENCE-BASED INTERVENTION? THERE IS GROWING EVIDENCE FOR YOGA'S NEUROBIOLOGICAL EFFECTS IN PEOPLE WITH PSYCHIATRIC DISORDERS. POSTULATED MECHANISMS OF ACTION INCLUDE: (A) MODULATION OF THE HYPOTHALAMIC-PITUITARY-ADRENAL (HPA) AXIS; (B) ENHANCEMENT OF GABAERGIC NEUROTRANSMISSION; (C) AUTONOMIC MODULATION; AND (D) NEUROENDOCRINOLOGICAL EFFECTS. YOGA AS A THERAPEUTIC INTERVENTION IN PSYCHIATRIC DISORDERS APPEARS PROMISING AND MERITS FURTHER ATTENTION IN CLINICAL PRACTICE AND RESEARCH. 2020 5 407 20 BIOLOGICAL SIGNIFICANCE OF PIEZOELECTRICITY IN RELATION TO ACUPUNCTURE, HATHA YOGA, OSTEOPATHIC MEDICINE AND ACTION OF AIR IONS. PIEZOELECTRIC PROPERTIES OF BIOLOGICAL MACROMOLECULES SUCH AS PROTEINS, NUCLEIC ACIDS AND MUCOPOLYSACCHARIDES ARE REVIEWED IN THIS PAPER. IT IS INDICATED THAT THE STRUCTURAL ELEMENTS OF THE HUMAN BODY COMPOSED OF THESE PIEZOELECTRIC SUBSTANCES ARE CAPABLE OF TRANSDUCING A MECHANICAL ENERGY INTO AN ELECTRIC CURRENT. SUCH A TRANSDUCTION MAY BE BROUGHT ABOUT BY MOVEMENTS OF AN ACUPUNCTURE NEEDLE, OSTEOPATHIC MANIPULATIONS; HATHA YOGA POSTURES OR ACTION OF NEGATIVELY CHARGED AIR IRONS. IT IS POSTULATED THAT ELECTRIC CURRENT INDUCED BY STIMULATION OF THE SPECIFIC SITES ON THE SURFACE OF HUMAN BODY FLOWS TOWARDS THE INTERNAL ORGANS ALONG THE SEMICONDUCTIVE CHANNELS OF BIOLOGIC MACROMOLECULES. ELECTRIC CURRENT INDUCED EITHER BY THE PIEZOELECTRIC TRANSDUCTION OR DIRECTLY APPLIED FROM AN EXTERNAL SOURCE MAY IN TURN STIMULATE INDIVIDUAL CELLS IN THE TARGET ORGAN. INVOLVEMENT OF ELECTRICAL PHENOMENA IN REGULATORY MECHANISMS ON CELLULAR AND MOLECULAR LEVELS IS DISCUSSED. 1977 6 1669 33 NEUROPHYSIOLOGICAL AND NEUROCOGNITIVE MECHANISMS UNDERLYING THE EFFECTS OF YOGA-BASED PRACTICES: TOWARDS A COMPREHENSIVE THEORETICAL FRAMEWORK. DURING RECENT DECADES NUMEROUS YOGA-BASED PRACTICES (YBP) HAVE EMERGED IN THE WEST, WITH THEIR AIMS RANGING FROM FITNESS GAINS TO THERAPEUTIC BENEFITS AND SPIRITUAL DEVELOPMENT. YOGA IS ALSO BEGINNING TO SPARK GROWING INTEREST WITHIN THE SCIENTIFIC COMMUNITY, AND YOGA-BASED INTERVENTIONS HAVE BEEN ASSOCIATED WITH MEASUREABLE CHANGES IN PHYSIOLOGICAL PARAMETERS, PERCEIVED EMOTIONAL STATES, AND COGNITIVE FUNCTIONING. YBP TYPICALLY INVOLVE A COMBINATION OF POSTURES OR MOVEMENT SEQUENCES, CONSCIOUS REGULATION OF THE BREATH, AND VARIOUS TECHNIQUES TO IMPROVE ATTENTIONAL FOCUS. HOWEVER, SO FAR LITTLE IF ANY RESEARCH HAS ATTEMPTED TO DECONSTRUCT THE ROLE OF THESE DIFFERENT COMPONENT PARTS IN ORDER TO BETTER UNDERSTAND THEIR RESPECTIVE CONTRIBUTION TO THE EFFECTS OF YBP. A CLEAR OPERATIONAL DEFINITION OF YOGA-BASED THERAPEUTIC INTERVENTIONS FOR SCIENTIFIC PURPOSES, AS WELL AS A COMPREHENSIVE THEORETICAL FRAMEWORK FROM WHICH TESTABLE HYPOTHESES CAN BE FORMULATED, IS THEREFORE NEEDED. HERE WE PROPOSE SUCH A FRAMEWORK, AND OUTLINE THE BOTTOM-UP NEUROPHYSIOLOGICAL AND TOP-DOWN NEUROCOGNITIVE MECHANISMS HYPOTHESIZED TO BE AT PLAY IN YBP. 2015 7 2714 36 YOGA LESSONS FOR CONSCIOUSNESS RESEARCH: A PARALIMBIC NETWORK BALANCING BRAIN RESOURCE ALLOCATION. CONSCIOUSNESS HAS BEEN PROPOSED TO PLAY A KEY ROLE IN SHAPING FLEXIBLE LEARNING AND AS SUCH IS THOUGHT TO CONFER AN EVOLUTIONARY ADVANTAGE. ATTENTION AND AWARENESS ARE THE PERHAPS MOST IMPORTANT UNDERLYING PROCESSES, YET THEIR PRECISE RELATIONSHIP IS PRESENTLY UNCLEAR. BOTH OF THESE PROCESSES MUST, HOWEVER, SERVE THE EVOLUTIONARY IMPERATIVES OF SURVIVAL AND PROCREATION. THEY ARE THUS INTIMATELY BOUND BY REWARD AND EMOTION TO HELP TO PRIORITIZE EFFICIENT BRAIN RESOURCE ALLOCATION IN ORDER TO PREDICT AND OPTIMIZE BEHAVIOR. HERE WE SHOW HOW THIS PROCESS IS SERVED BY A PARALIMBIC NETWORK CONSISTING PRIMARILY OF REGIONS LOCATED ON THE MIDLINE OF THE HUMAN BRAIN. USING MANY DIFFERENT TECHNIQUES, EXPERIMENTS HAVE DEMONSTRATED THAT THIS NETWORK IS EFFECTIVE AND SPECIFIC FOR SELF-AWARENESS AND CONTRIBUTES TO THE SENSE OF UNITY OF CONSCIOUSNESS BY ACTING AS A COMMON NEURAL PATH FOR A WIDE VARIETY OF CONSCIOUS EXPERIENCES. INTERESTINGLY, HEMODYNAMIC ACTIVITY IN THE NETWORK DECREASES WITH FOCUSING ON EXTERNAL STIMULI, WHICH HAS LED TO THE IDEA OF A DEFAULT MODE NETWORK. THIS NETWORK IS ONE OF MANY NETWORKS THAT WAX AND VANE AS RESOURCES ARE ALLOCATED TO ACCOMMODATE THE DIFFERENT CYCLICAL NEEDS OF THE ORGANISM PRIMARILY RELATED TO THE FUNDAMENTAL PLEASURES AFFORDED BY EVOLUTION: FOOD, SEX, AND CONSPECIFICS. HERE WE HYPOTHESIZE, HOWEVER, THAT THE PARALIMBIC NETWORK SERVES A CRUCIAL ROLE IN BALANCING AND REGULATING BRAIN RESOURCE ALLOCATION, AND DISCUSS HOW IT CAN BE THOUGHT OF AS A LINK BETWEEN CURRENT THEORIES OF SO-CALLED "DEFAULT MODE," "RESTING STATE NETWORKS," AND "GLOBAL WORKSPACE." WE SHOW HOW MAJOR DEVELOPMENTAL DISORDERS OF SELF-AWARENESS AND SELF-CONTROL CAN ARISE FROM PROBLEMS IN THE PARALIMBIC NETWORK AS DEMONSTRATED HERE BY THE EXAMPLE OF ASPERGER SYNDROME. WE CONCLUDE THAT ATTENTION, AWARENESS, AND EMOTION ARE INTEGRATED BY A PARALIMBIC NETWORK THAT HELPS TO EFFICIENTLY ALLOCATE BRAIN RESOURCES TO OPTIMIZE BEHAVIOR AND HELP SURVIVAL. 2011 8 2436 35 YOGA AND PSYCHIATRIC DISORDERS: A REVIEW OF BIOMARKER EVIDENCE. TRADITIONALLY, YOGA HAS BEEN USED AS A MEANS FOR SPIRITUAL GROWTH BUT OVER THE PAST TWO DECADES OR SO ITS THERAPEUTIC BENEFITS IN PSYCHIATRIC DISORDERS HAVE BEEN SCIENTIFICALLY EXPLORED. YOGA HAS BEEN SHOWN TO BE USEFUL AS A MONO-THERAPY IN MILD TO MODERATE DEPRESSION AND AS AN ADJUVANT IN SEVERAL PSYCHIATRIC DISORDERS INCLUDING SCHIZOPHRENIA, ANXIETY DISORDERS, SUBSTANCE USE DISORDERS AND MILD COGNITIVE IMPAIRMENT. FURTHERMORE, SYSTEMATIC ATTEMPTS HAVE BEEN MADE TO UNDERSTAND THE BIOLOGICAL CORRELATES OF YOGA IN THESE PSYCHIATRIC DISORDERS. GIVEN THAT NO PSYCHIATRIC DISORDER HAS STRONG AND ESTABLISHED BIOMARKERS, IT IS INTERESTING THAT PRELIMINARY RESEARCH HAS DEMONSTRATED SIGNIFICANT CHANGES IN CERTAIN IMPORTANT BIOMARKERS FOLLOWING REGULAR YOGA PRACTICE. IN THIS BRIEF REVIEW, WE PROVIDE AN UPDATE ON THE EFFECTS OF YOGA ON BIOCHEMICAL, NEURO-PHYSIOLOGICAL AND NEURO-IMAGING RELATED BIO-MARKERS IN PSYCHIATRIC DISORDERS. ALTHOUGH FINDINGS AND TRENDS ARE PROMISING, MUCH MORE RESEARCH IS WARRANTED TO ESTABLISH A DEFINITE BIOLOGICAL BASIS FOR YOGA IN PSYCHIATRY. 2021 9 2297 25 THERAPEUTIC ROLE OF YOGA IN NEUROPSYCHOLOGICAL DISORDERS. YOGA IS CONSIDERED A WIDELY-USED APPROACH FOR HEALTH CONSERVATION AND CAN BE ADOPTED AS A TREATMENT MODALITY FOR A PLETHORA OF MEDICAL CONDITIONS, INCLUDING NEUROLOGICAL AND PSYCHOLOGICAL DISORDERS. HENCE, WE REVIEWED RELEVANT ARTICLES ENTAILING VARIOUS NEUROLOGICAL AND PSYCHOLOGICAL DISORDERS AND GATHERED DATA ON HOW YOGA EXERTS POSITIVE IMPACTS ON PATIENTS WITH A DIVERSE RANGE OF DISORDERS, INCLUDING ITS MODULATORY EFFECTS ON BRAIN BIOELECTRICAL ACTIVITIES, NEUROTRANSMITTERS, AND SYNAPTIC PLASTICITY. THE ROLE OF YOGA PRACTICE AS AN ELEMENT OF THE TREATMENT OF SEVERAL NEUROPSYCHOLOGICAL DISEASES WAS EVALUATED BASED ON THESE FINDINGS. 2021 10 1772 39 POTENTIAL SELF-REGULATORY MECHANISMS OF YOGA FOR PSYCHOLOGICAL HEALTH. RESEARCH SUGGESTING THE BENEFICIAL EFFECTS OF YOGA ON MYRIAD ASPECTS OF PSYCHOLOGICAL HEALTH HAS PROLIFERATED IN RECENT YEARS, YET THERE IS CURRENTLY NO OVERARCHING FRAMEWORK BY WHICH TO UNDERSTAND YOGA'S POTENTIAL BENEFICIAL EFFECTS. HERE WE PROVIDE A THEORETICAL FRAMEWORK AND SYSTEMS-BASED NETWORK MODEL OF YOGA THAT FOCUSES ON INTEGRATION OF TOP-DOWN AND BOTTOM-UP FORMS OF SELF-REGULATION. WE BEGIN BY CONTEXTUALIZING YOGA IN HISTORICAL AND CONTEMPORARY SETTINGS, AND THEN DETAIL HOW SPECIFIC COMPONENTS OF YOGA PRACTICE MAY AFFECT COGNITIVE, EMOTIONAL, BEHAVIORAL, AND AUTONOMIC OUTPUT UNDER STRESS THROUGH AN EMPHASIS ON INTEROCEPTION AND BOTTOM-UP INPUT, RESULTING IN PHYSICAL AND PSYCHOLOGICAL HEALTH. THE MODEL DESCRIBES YOGA PRACTICE AS A COMPREHENSIVE SKILLSET OF SYNERGISTIC PROCESS TOOLS THAT FACILITATE BIDIRECTIONAL FEEDBACK AND INTEGRATION BETWEEN HIGH- AND LOW-LEVEL BRAIN NETWORKS, AND AFFERENT AND RE-AFFERENT INPUT FROM INTEROCEPTIVE PROCESSES (SOMATOSENSORY, VISCEROSENSORY, CHEMOSENSORY). FROM A PREDICTIVE CODING PERSPECTIVE WE PROPOSE A SHIFT TO PERCEPTUAL INFERENCE FOR STRESS MODULATION AND OPTIMAL SELF-REGULATION. WE DESCRIBE HOW THE PROCESSES THAT SUB-SERVE SELF-REGULATION BECOME MORE AUTOMATIZED AND EFFICIENT OVER TIME AND PRACTICE, REQUIRING LESS EFFORT TO INITIATE WHEN NECESSARY AND TERMINATE MORE RAPIDLY WHEN NO LONGER NEEDED. TO SUPPORT OUR PROPOSED MODEL, WE PRESENT THE AVAILABLE EVIDENCE FOR YOGA AFFECTING SELF-REGULATORY PATHWAYS, INTEGRATING EXISTING CONSTRUCTS FROM BEHAVIOR THEORY AND COGNITIVE NEUROSCIENCE WITH EMERGING YOGA AND MEDITATION RESEARCH. THIS PAPER IS INTENDED TO GUIDE FUTURE BASIC AND CLINICAL RESEARCH, SPECIFICALLY TARGETING AREAS OF DEVELOPMENT IN THE TREATMENT OF STRESS-MEDIATED PSYCHOLOGICAL DISORDERS. 2014 11 2420 21 YOGA AND MENTAL HEALTH: A DIALOGUE BETWEEN ANCIENT WISDOM AND MODERN PSYCHOLOGY. BACKGROUND: MANY YOGA TEXTS MAKE REFERENCE TO THE IMPORTANCE OF MENTAL HEALTH AND THE USE OF SPECIFIC TECHNIQUES IN THE TREATMENT OF MENTAL DISORDERS. DIFFERENT CONCEPTS UTILIZED IN MODERN PSYCHOLOGY MAY NOT COME WITH CONTEMPORARY IDEAS, INSTEAD, THEY SEEM TO SHARE A COMMON ROOT WITH ANCIENT WISDOM. AIMS: THE GOAL OF THIS PERSPECTIVE ARTICLE IS TO CORRELATE MODERN TECHNIQUES USED IN PSYCHOLOGY AND PSYCHIATRY WITH YOGIC PRACTICES, IN THE TREATMENT OF MENTAL DISORDERS. MATERIALS AND METHODS: THE CURRENT ARTICLE PRESENTED A DIALOGUE BETWEEN THE YOGIC APPROACH FOR THE TREATMENT OF MENTAL DISORDER AND CONCEPTS USED IN MODERN PSYCHOLOGY, SUCH AS META-COGNITION, DISIDENTIFICATION, DECONDITIONING AND INTEROCEPTIVE EXPOSURE. CONCLUSIONS: CONTEMPLATIVE RESEARCH FOUND OUT THAT MODERN INTERVENTIONS IN PSYCHOLOGY MIGHT NOT COME FROM MODERN CONCEPTS AFTER ALL, BUT SHARE GREAT SIMILARITY WITH ANCIENT YOGIC KNOWLEDGE, GIVING US THE OPPORTUNITY TO INTEGRATE THE PSYCHOLOGICAL WISDOM OF BOTH EAST AND WEST. 2016 12 1649 24 MULTI-OMICS INTEGRATION AND INTERACTOMICS REVEALS MOLECULAR NETWORKS AND REGULATORS OF THE BENEFICIAL EFFECT OF YOGA AND EXERCISE. BACKGROUND: YOGA IS A MULTIFACETED SPIRITUAL TOOL THAT HELPS IN MAINTAINING HEALTH, PEACE OF MIND, AND POSITIVE THOUGHTS. IN THE CONTEXT OF ASANA, YOGA IS SIMILAR TO PHYSICAL EXERCISE. THIS STUDY AIMS TO CONSTRUCT A MOLECULAR NETWORK TO FIND HUB GENES THAT PLAY IMPORTANT ROLES IN PHYSICAL EXERCISE AND YOGA. METHODOLOGY: WE COMBINED DIFFERENTIALLY EXPRESSED GENES (DEGS) IN YOGA AND EXERCISE USING COMPUTATIONAL BIOINFORMATICS FROM PUBLICLY AVAILABLE GENE EXPRESSION OMNIBUS (GEO) DATASETS AND IDENTIFIED THE CODIFFERENTIALLY EXPRESSED MRNAS WITH GEO2R. THE CO-DEGS WERE DIVIDED INTO FOUR DIFFERENT GROUPS AND EACH GROUP WAS SUBJECTED TO PROTEIN-PROTEIN INTERACTION (PPI) NETWORK, PATHWAYS ANALYSIS, AND GENE ONTOLOGY. RESULTS: OUR STUDY IDENTIFIED IMMUNOLOGICAL MODULATION AS A DOMINANT TARGET OF DIFFERENTIAL EXPRESSION IN YOGA AND EXERCISE. YOGA PREDOMINANTLY MODULATED GENES AFFECTING THE TH1 AND NK CELLS, WHEREAS CYTOKINES, MACROPHAGE ACTIVATION, AND OXIDATIVE STRESS WERE AFFECTED BY EXERCISE. WE ALSO OBSERVED THAT WHILE YOGA REGULATED GENES FOR TWO MAIN PHYSIOLOGICAL FUNCTIONS OF THE BODY, NAMELY CIRCADIAN RHYTHM (BHLHE40) AND IMMUNITY (LBP, T-BOX TRANSCRIPTION FACTOR 21, CEACAM1), EXERCISE-REGULATED GENES INVOLVED IN APOPTOSIS (BAG3, PROTEIN KINASE C ALPHA), ANGIOGENESIS, AND CELLULAR ADHESION (EPH RECEPTOR A1). CONCLUSION: THE DISSIMILARITY IN THE GENETIC EXPRESSION PATTERNS IN YOGA AND EXERCISE HIGHLIGHTS THE DISCRETE EFFECT OF EACH IN BIOLOGICAL SYSTEMS. THE INTEGRATION AND CONVERGENCES OF MULTI-OMICS SIGNALS CAN PROVIDE DEEPER AND COMPREHENSIVE INSIGHTS INTO THE VARIOUS BIOLOGICAL MECHANISMS THROUGH WHICH YOGA AND EXERCISE EXERT THEIR BENEFICIAL EFFECTS AND OPENS UP POTENTIAL NEWER RESEARCH AREAS. 2022 13 1890 32 REGULATION OF GENE EXPRESSION BY YOGA, MEDITATION AND RELATED PRACTICES: A REVIEW OF RECENT STUDIES. INTEGRATIVE MEDICINE (IM) APPROACHES HAVE GAINED SIGNIFICANT INTEREST IN RECENT YEARS TO PROVIDE A SOLUTION FOR THE HEALTH CARE CHALLENGES WE FACE TODAY. YOGIC COGNITIVE-BEHAVIORAL PRACTICES ARE AMONG THE MOST WIDELY USED IM APPROACHES AND INCLUDE DIVERSE PRACTICES SUCH AS YOGA ASANAS, MEDITATION, BREATHING EXERCISES, QI GONG, TAI CHI CHIH, AND VARIOUS OTHERS. STUDIES TO DATE SUGGEST THAT THESE YOGIC/MEDITATIVE PRACTICES HAVE SIGNIFICANT POSITIVE EFFECTS ON THE MIND-BODY SYSTEM AND THEREBY CAN INCREASE WELLNESS AND SUPPORT THE HEALING PROCESS FROM DISEASE. PREVIOUS WORK HAS PROVIDED EVIDENCE FOR BOTH PSYCHOLOGICAL AND PHYSIOLOGICAL EFFECTS OF THESE PRACTICES; HOWEVER, THE MECHANISMS OF THESE EFFECTS, ESPECIALLY AT THE MOLECULAR LEVEL, HAVE LARGELY BEEN MISSING. THREE RECENT STUDIES STARTED TO PROVIDE SOME OF THIS INFORMATION THROUGH GENE EXPRESSION PROFILING IN CIRCULATING IMMUNE CELLS, WHICH SUPPORT THE HYPOTHESIS THAT YOGIC/MEDITATIVE PRACTICES HAVE A MEASURABLE EFFECT AT THE MOLECULAR LEVEL. THESE STUDIES ARE REVIEWED HEREIN AND SOME FUTURE PERSPECTIVES ARE CONSIDERED. 2013 14 1590 22 MEDITATION AND YOGA CAN MODULATE BRAIN MECHANISMS THAT AFFECT BEHAVIOR AND ANXIETY-A MODERN SCIENTIFIC PERSPECTIVE. MEDITATION AND YOGA TECHNIQUES ARE RECEIVING INCREASED ATTENTION THROUGHOUT THE WORLD, DUE TO THE ACCUMULATION OF EVIDENCE BASED RESEARCH THAT PROVES THE DIRECT AND INDIRECT BENEFITS OF SUCH PRACTICES. BASED ON STUDIES CONDUCTED SO FAR, IT HAS BEEN FOUND THAT THE PRACTICE OF MEDITATION TRIGGERS NEUROTRANSMITTERS THAT MODULATE PSYCHOLOGICAL DISORDERS SUCH AS ANXIETY. THIS PAPER WILL REVIEW THE PSYCHOLOGICAL EFFECTS OF THE PRACTICE OF MEDITATION, THE ROLE OF NEUROTRANSMITTERS, AND STUDIES USING EEG AND FMRI. 2015 15 422 36 BRIDGING THE SCHISM OF SCHIZOPHRENIA THROUGH YOGA-REVIEW OF PUTATIVE MECHANISMS. SCHIZOPHRENIA PATIENTS EXPERIENCE A 'DISCONNECT' AT MULTIPLE LEVELS-NEURONAL NETWORKS, MENTAL PROCESSES, AND INTERPERSONAL RELATIONSHIPS. THE RESULTANT POOR QUALITY-OF-LIFE AND FUNCTIONAL DISABILITY ARE RELATED TO THE PERSISTENT COGNITIVE DEFICITS AND NEGATIVE SYMPTOMS, WHICH ARE RATHER RESISTANT TO CONVENTIONAL ANTIPSYCHOTIC MEDICATIONS. YOGA HAS EMERGED AS AN IMPORTANT THERAPEUTIC INTERVENTION TO IMPROVE QUALITY-OF-LIFE IN SCHIZOPHRENIA. RECENT PRELIMINARY EVIDENCE SUGGESTS THAT EFFECTS OF YOGA ON COGNITIVE AND NEGATIVE SYMPTOMS MAY DRIVE THIS BENEFIT. THIS STUDY ATTEMPTS TO INTEGRATE EVIDENCE FROM NEUROSCIENCE-BASED RESEARCH, WHICH FOCUSES ON THE NEUROPLASTICITY-HARNESSING EFFECTS OF YOGA TO BRIDGE THE SCHIZOPHRENIA CONNECTOPATHY. IN AN OVERARCHING MODEL TO STUDY PUTATIVE NEUROBIOLOGICAL MECHANISMS THAT DRIVE THERAPEUTIC EFFECTS OF YOGA, IT IS PROPOSED THAT (A) VARIOUS STYLES OF MEDITATION MAY HELP IN STRENGTHENING THE LATERAL AND MEDIAL PREFRONTAL BRAIN NETWORKS, THUS IMPROVING NEUROCOGNITION AND MENTALIZING ABILITIES, AND (B) LEARNING AND PERFORMING CO-ORDINATED PHYSICAL POSTURES WITH A TEACHER FACILITATES IMITATION AND THE PROCESS OF BEING IMITATED, WHICH CAN IMPROVE SOCIAL COGNITION AND EMPATHY THROUGH REINFORCEMENT OF THE PREMOTOR AND PARIETAL MIRROR NEURON SYSTEM. OXYTOCIN MAY PLAY A ROLE IN MEDIATING THESE PROCESSES, LEADING TO BETTER SOCIAL CONNECTEDNESS AND SOCIAL OUTCOMES. CLINICAL AND HEURISTIC IMPLICATIONS OF THIS MODEL ARE FURTHER DISCUSSED. 2016 16 571 25 DEFINING YOGA-NIDRA: TRADITIONAL ACCOUNTS, PHYSIOLOGICAL RESEARCH, AND FUTURE DIRECTIONS. THE TERM YOGA-NIDRA HAS BEEN USED IN MANY EMPIRICAL STUDIES TO REFER TO RELAXATION AND GUIDED IMAGERY. THESE TECHNIQUES DO NOT REPRESENT THE INTENTION OR PHYSIOLOGICAL CORRELATES OF YOGANIDRA DISCUSSED IN THE TRADITIONAL YOGA LITERATURE. WE PROPOSE AN OPERATIONAL DEFINITION OF YOGA-NIDRA THAT IS SUPPORTED BY SEVERAL PHYSIOLOGICALLY TESTABLE HYPOTHESES REGARDING ITS OUTCOMES AND EFFECTS. TRADITIONAL DESCRIPTIONS OF YOGA-NIDRA AND CONTEMPORARY ACCOUNTS OF ITS PRACTICE ARE REVIEWED, AND STUDIES EXAMINING THE PHYSIOLOGICAL CORRELATES OF YOGA-NIDRA ARE EXAMINED. PROPOSED HYPOTHESES FOR FUTURE RESEARCH USING THIS OPERATIONAL DEFINITION ARE PROVIDED. 2013 17 1335 29 HOW DOES YOGA PRACTICE AND THERAPY YIELD PSYCHOLOGICAL BENEFITS? A REVIEW AND MODEL OF TRANSDIAGNOSTIC PROCESSES. INTEREST IN YOGA AS AN INTERVENTION FOR PSYCHOLOGICAL WELLBEING HAS INCREASED IN RECENT YEARS, WITH LITERATURE INVESTIGATING BENEFICIAL EFFECTS IN A VARIETY OF PRESENTATIONS AND SETTINGS. THE THEORETICAL UNDERSTANDING OF THIS BENEFIT HAS PREVIOUSLY FOCUSED ON PHYSIOLOGICAL CHANGES INVOLVED IN YOGA PRACTICE, HOWEVER INTEREST HAS TURNED TO THE POTENTIAL PSYCHOLOGICAL MECHANISMS ELICITING PSYCHOLOGICAL WELLBEING. THE CURRENT PAPER BUILDS ON PREVIOUS THEORY AND ARGUES THAT YOGA PRACTICE TARGETS TRANSDIAGNOSTIC PSYCHOLOGICAL PROCESSES; MECHANISMS THAT FEATURE COMMONLY ACROSS A WIDE RANGE OF PRESENTATIONS, THUS REDUCING DISTRESS AND INCREASING WELLBEING ACROSS CLINICAL AND NON-CLINICAL POPULATIONS. FEATURES OF YOGA PRACTICE ARE DISCUSSED IN RELATION TO THESE TRANSDIAGNOSTIC PROCESSES AND THE FEATURES OF MODERN TALKING THERAPIES. A NEW MODEL IS PROPOSED POSITING SPECIFIC ASPECTS OF YOGA PRACTICE CORRELATE WITH SPECIFIC TRANSDIAGNOSTIC PROCESSES TO ELICIT PSYCHOLOGICAL CHANGE AND ARGUES THAT THE MECHANISMS BY WHICH CHANGE OCCURS ARE DIRECTLY COMPARED WITH THE CHANGES OBSERVED IN TALKING THERAPIES. THE IMPLICATIONS FOR FUTURE RESEARCH AND THE POTENTIAL FOR THIS TO SUPPORT THE COMMISSIONING OF HOLISTIC APPROACHES IN CLINICAL PRACTICE ARE DISCUSSED. 2022 18 1502 16 INVEST IN YOURSELF. YOGA AS A SELF-CARE STRATEGY. A WIDENING RECOGNITION OF THE MIND-BODY-SPIRIT CONNECTION IN WESTERN MEDICINE HAS RESULTED IN A GROWING INTEREST IN ANCIENT HEALTH PRACTICES SUCH AS YOGA. AS COMPLEMENTARY THERAPIES ENTER MAINSTREAM MEDICAL SETTINGS, NURSES AND OTHER HEALTHCARE PROVIDERS NEED A FUNDAMENTAL UNDERSTANDING OF THESE MODALITIES TO BE ABLE TO ADVISE PATIENTS EFFECTIVELY. THIS ARTICLE PROVIDES AN OVERVIEW OF YOGA AND DETAILS THE BENEFITS OF YOGA PRACTICE. 2000 19 653 20 EATING DISORDERS, EMBODIMENT, AND YOGA: A CONCEPTUAL OVERVIEW. YOGA AND ITS RELATION TO EMBODIMENT AND DISORDERED EATING HAS ONLY RECENTLY RECEIVED RESEARCH ATTENTION. NEVERTHELESS, EARLY RESEARCH INDICATES THAT YOGA IS AN EFFECTIVE TOOL IN THE PREVENTION AND TREATMENT OF EATING DISORDERS. IT IS ASSUMED THAT YOGA AMELIORATES EATING DISORDER SYMPTOMS AND FACILITATES A SHIFT FROM NEGATIVE TOWARDS POSITIVE BODY IMAGE AND WELL-BEING BY CULTIVATING POSITIVE EMBODIMENT (I.E., THE ABILITY TO FEEL A SENSE OF CONNECTION BETWEEN MIND AND BODY). IN ORDER TO PROVIDE THE CONTEXT OF THE CONSTRUCTS OF DISORDERED EATING, EMBODIMENT, AND YOGA, THIS ARTICLE PRESENTS A BRIEF OVERVIEW AND CONCEPTUALIZATION OF THESE CONSTRUCTS. THE THREE MAJOR EATING DISORDERS AND CURRENT TREATMENT METHODS ARE DESCRIBED. FURTHER, THE PHILOSOPHICAL ROOTS AND THEORETICAL MODELS OF EMBODIMENT ARE DELINEATED AND THEIR COMMUNAL CORE FEATURES ARE OUTLINED. LASTLY, THE ORIGIN, BASIC PRINCIPLES, AND MODERN INTERPRETATIONS OF YOGA ARE DISCUSSED. 2020 20 2512 26 YOGA BREATHING, MEDITATION, AND LONGEVITY. YOGA BREATHING IS AN IMPORTANT PART OF HEALTH AND SPIRITUAL PRACTICES IN INDO-TIBETAN TRADITIONS. CONSIDERED FUNDAMENTAL FOR THE DEVELOPMENT OF PHYSICAL WELL-BEING, MEDITATION, AWARENESS, AND ENLIGHTENMENT, IT IS BOTH A FORM OF MEDITATION IN ITSELF AND A PREPARATION FOR DEEP MEDITATION. YOGA BREATHING (PRANAYAMA) CAN RAPIDLY BRING THE MIND TO THE PRESENT MOMENT AND REDUCE STRESS. IN THIS PAPER, WE REVIEW DATA INDICATING HOW BREATH WORK CAN AFFECT LONGEVITY MECHANISMS IN SOME WAYS THAT OVERLAP WITH MEDITATION AND IN OTHER WAYS THAT ARE DIFFERENT FROM, BUT THAT SYNERGISTICALLY ENHANCE, THE EFFECTS OF MEDITATION. WE ALSO PROVIDE CLINICAL EVIDENCE FOR THE USE OF YOGA BREATHING IN THE TREATMENT OF DEPRESSION, ANXIETY, POST-TRAUMATIC STRESS DISORDER, AND FOR VICTIMS OF MASS DISASTERS. BY INDUCING STRESS RESILIENCE, BREATH WORK ENABLES US TO RAPIDLY AND COMPASSIONATELY RELIEVE MANY FORMS OF SUFFERING. 2009