1 2550 127 YOGA FOR CANCER-RELATED FATIGUE IN SURVIVORS OF HEMATOPOIETIC CELL TRANSPLANTATION: A FEASIBILITY STUDY. CONTEXT: CANCER-RELATED FATIGUE (CRF) IS ONE OF THE MOST COMMON SYMPTOMS EXPERIENCED BY CANCER PATIENTS AFTER HEMATOPOIETIC CELL TRANSPLANTATION (HCT). YOGA IS AN APPROACH WITH SUPPORTIVE EVIDENCE TO IMPROVE CRF IN DIFFERENT CANCER POPULATIONS, BUT TO OUR KNOWLEDGE, IT HAS NOT BEEN TESTED IN AN ADULT HCT POPULATION. OBJECTIVES: THE AIM OF THIS STUDY WAS TO EVALUATE THE FEASIBILITY OF A YOGA INTERVENTION OFFERED TO ADULT HCT SURVIVORS WITH MODERATE-TO-SEVERE CRF. METHODS: THIS FEASIBILITY STUDY USED A SINGLE-ARM, PRETEST-POSTTEST DESIGN. ADULT HCT SURVIVORS WERE ENROLLED IN A SIX-WEEK RESTORATIVE YOGA INTERVENTION THAT CONSISTED OF A ONE-HOUR ONCE-WEEKLY CLASS WITH TWICE-WEEKLY HOME PRACTICE USING A DVD. RESULTS: TWENTY PARTICIPANTS (13 WOMEN AND SEVEN MEN) ENROLLED IN THIS STUDY WITH A MEAN AGE OF 51 YEARS (SD = 12.5). THE SAMPLE CONSISTED OF 19 ALLOGENEIC HCT SURVIVORS, SEVEN OF WHOM HAD A HISTORY OF ACUTE GRAFT-VS.-HOST DISEASE (GVHD), SIX WITH ACTIVE, EXTENSIVE CHRONIC GVHD, AND ONE AUTOLOGOUS HCT SURVIVOR. THE ACCRUAL ACCEPTANCE RATE WAS 23.2% (20/86 HCT SURVIVORS) AND RETENTION RATE WAS 60% (12/20). OVERALL ADHERENCE WAS 45.4%. NO ADVERSE EVENTS WERE REPORTED. CONCLUSION: THE RESULTS OF THIS STUDY SUGGEST THAT A RESTORATIVE YOGA INTERVENTION IN ADULT HCT SURVIVORS IS SAFE AND FEASIBLE. THE INCIDENCE OF GVHD MAY HAVE IMPACTED ADHERENCE. STRATEGIES TO IMPROVE ACCRUAL ACCEPTANCE, RETENTION, AND ADHERENCE ARE NEEDED.	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
2  446  32 CHALLENGES OF IMPLEMENTING MULTICENTER STUDIES OF YOGA FOR PEDIATRIC CANCER AND HEMATOPOIETIC STEM CELL TRANSPLANTATION RECIPIENTS. THE PRIMARY OBJECTIVE OF THIS WORK WAS TO DETERMINE THE FEASIBILITY OF A RANDOMIZED TRIAL OF INDIVIDUALIZED YOGA FOR CHILDREN RECEIVING INTENSIVE CHEMOTHERAPY AND FOR HEMATOPOIETIC STEM CELL TRANSPLANTATION (HSCT) RECIPIENTS OUTSIDE OF THE PRINCIPAL COORDINATING INSTITUTION. WE EVALUATED THE FEASIBILITY OF A RANDOMIZED TRIAL OF INDIVIDUALIZED YOGA VERSUS AN IPAD CONTROL PROGRAM AT A SITE WHERE EXTERNAL YOGA INSTRUCTORS WERE HIRED AND COMPENSATED PER SESSION. SUBJECTS WERE CHILDREN RECEIVING INTENSIVE CHEMOTHERAPY FOR HEMATOLOGICAL MALIGNANCIES AND AUTOLOGOUS OR ALLOGENEIC HSCT RECIPIENTS EXPECTED TO BE HOSPITALIZED FOR 3 WEEKS. YOGA OR IPAD CONTROL CONTACT OCCURRED DAILY FOR 21 DAYS (EXCLUDING WEEKENDS AND HOLIDAYS); FATIGUE AND QUALITY-OF-LIFE OUTCOMES WERE MEASURED AT BASELINE, DAY 10, AND DAY 21. TEN ELIGIBLE SUBJECTS WERE IDENTIFIED; SIX SUBJECTS CONSENTED AND WERE ENROLLED. THREE WERE RANDOMIZED TO THE INDIVIDUALIZED YOGA INTERVENTION AND THREE TO THE IPAD CONTROL PROGRAM. THE MEDIAN AGE OF PARTICIPANTS WAS 12 (RANGE 8-15) YEARS, AND 2 (33%) WERE BOYS. CHALLENGES PRIMARILY RELATED TO THE HIRING OF YOGA INSTRUCTORS WHO WERE NOT TRAINED IN RESEARCH METHODS. WE FOUND ISSUES WITH: (1) LOGISTICS OF HIRING, TRAINING, AND RETAINING INSTRUCTORS; (2) COMMUNICATION BETWEEN TEAMS; (3) FIDELITY TO THE PROTOCOL AND OUTCOME ASSESSMENTS; AND (4) ENSURING SAFETY. WE FOUND THAT A RANDOMIZED TRIAL OF INDIVIDUALIZED YOGA PRESENTED NEW CHALLENGES WHEN RELYING ON EXTERNALLY CONTRACTED YOGA INSTRUCTORS. FUTURE MULTICENTER STUDIES OF YOGA SHOULD SEEK TO BETTER INTEGRATE PRACTITIONERS WITHIN THE RESEARCH TEAM TO IMPROVE PROCESSES, COMMUNICATION, FIDELITY TO THE PROTOCOL, AND SAFETY.	2021	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
3  127  38 A PILOT STUDY TO EVALUATE THE FEASIBILITY OF INDIVIDUALIZED YOGA FOR INPATIENT CHILDREN RECEIVING INTENSIVE CHEMOTHERAPY. BACKGROUND: FATIGUE IS AN IMPORTANT PROBLEM IN PAEDIATRIC CANCER PATIENTS AND YOGA MAY BE AN EFFECTIVE INTERVENTION. THE PRIMARY OBJECTIVE WAS TO DETERMINE THE FEASIBILITY OF INDIVIDUALIZED YOGA FOR HOSPITALIZED CHILDREN RECEIVING INTENSIVE CHEMOTHERAPY. METHODS: WE INCLUDED ENGLISH-SPEAKING CHILDREN AND ADOLESCENTS AGED 7-18 YEARS RECEIVING INTENSIVE CHEMOTHERAPY OR HAEMATOPOIETIC STEM CELL TRANSPLANTATION (HSCT). YOGA WAS CONDUCTED THREE TIMES WEEKLY FOR THREE WEEKS. THE PRIMARY OUTCOME WAS FEASIBILITY, DEFINED AS ABILITY TO DELIVER AT LEAST 60% OF PLANNED SESSIONS. SECONDARY OUTCOMES WERE PARENT-REPORTED PEDIATRIC QUALITY OF LIFE INVENTORY (PEDSQL) MULTIDIMENSIONAL FATIGUE SCALE, FATIGUE SCALE-PARENT, PEDSQL GENERIC CORE SCALES AND PEDSQL ACUTE CANCER MODULE. RESULTS: BETWEEN JANUARY AND OCTOBER 2013, 11 PATIENTS WERE ENROLLED. MEDIAN AGE WAS 14.0 (RANGE 7.7-16.4) YEARS AND 6 (55%) WERE BOYS. YOGA WAS FEASIBLE WITH 10/11 PARTICIPANTS MEETING THE THRESHOLD FOR FEASIBILITY. THE MEDIAN NUMBER OF YOGA SESSIONS WAS 9 (RANGE 3-13). NO ADVERSE EVENTS WERE ATTRIBUTED TO YOGA. MEAN+/-STANDARD DEVIATION FOR THE DAY 21 PROXY-REPORTED PEDSQL GENERAL FATIGUE SCORES WAS 55.6+/-15.5. QUALITATIVE COMMENTS SUGGESTED DESIGN CHANGES FOR FUTURE YOGA STUDIES. CONCLUSIONS: INDIVIDUALIZED YOGA IS FEASIBLE FOR INPATIENT CHILDREN RECEIVING INTENSIVE CHEMOTHERAPY. FUTURE WORK WILL INCLUDE DEVELOPMENT AND CONDUCT OF A RANDOMIZED TRIAL FOR FATIGUE AMELIORATION. TRIAL REGISTRATION: CLINICALTRIALS.GOV NCT02105389.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
4  615  35 DEVELOPMENT OF AN INDIVIDUALIZED YOGA INTERVENTION TO ADDRESS FATIGUE IN HOSPITALIZED CHILDREN UNDERGOING INTENSIVE CHEMOTHERAPY. PURPOSE FATIGUE IS AN IMPORTANT PROBLEM IN CHILDREN RECEIVING INTENSIVE CHEMOTHERAPY AND HEMATOPOIETIC STEM CELL TRANSPLANTATION (HSCT). EXERCISE MAY BE AN EFFECTIVE INTERVENTION FOR FATIGUE. INDIVIDUALIZED YOGA REPRESENTS AN IDEAL INTERVENTION BECAUSE IT CAN BE TAILORED ACCORDING TO AN INDIVIDUAL CHILD'S NEEDS. LITTLE IS KNOWN ABOUT HOW TO STRUCTURE A STANDARDIZED YOGA PROGRAM FOR INTENSIVELYTREATED CHILDREN. THEREFORE, THIS STUDY DESCRIBES THE DEVELOPMENT OF A YOGA PROGRAM AND AN APPROACH TO MONITORING SESSIONS SUITABLE FOR HOSPITALIZED CHILDREN RECEIVING INTENSIVE CHEMOTHERAPY OR HSCT. METHODS THE YOGA PROGRAM WAS DESIGNED TO INCREASE MOBILITY IN HOSPITALIZED CHILDREN AND TO PROVIDE CHILDREN WITH RELAXATION TECHNIQUES THAT COULD BE USED INDEPENDENTLY IN A VARIETY OF ENVIRONMENTS. THE PROGRAM WAS FOUNDED ON 4 KEY TENETS: SAFETY, ADAPTABILITY, ENVIRONMENTAL FLEXIBILITY, AND APPEAL TO CHILDREN. WE ALSO DEVELOPED QUALITY AND CONSISTENCY ASSURANCE PROCEDURES. RESULTS A MENU FORMAT WITH A FIXED STRUCTURE WAS SELECTED FOR THE YOGA PROGRAM. EACH YOGA SESSION CONTAINED UP TO 6 SECTIONS: BREATHING EXERCISES, WARMUP EXERCISES, YOGA POSES, BALANCING POSES, COOL-DOWN POSES, AND FINAL RELAXATION. YOGA INSTRUCTORS SELECTED SPECIFIC YOGA POSES FOR EACH SESSION FROM A PREDETERMINED LIST ORGANIZED BY INTENSITY LEVEL (LOW, MODERATE, OR HIGH). MONITORING PROCEDURES WERE DEVELOPED USING VIDEOTAPING AND MULTIRATER ADJUDICATION. CONCLUSION WE CREATED A STANDARDIZED YOGA PROGRAM AND AN APPROACH TO MONITORING THAT ARE NOW READY FOR INCORPORATION IN CLINICAL TRIALS. FUTURE WORK SHOULD INCLUDE THE ADAPTATION OF THE PROGRAM TO DIFFERENT PEDIATRIC POPULATIONS AND CLINICAL SETTINGS.	2016	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
5 1460  37 INFLUENCE OF YOGA ON CANCER-RELATED FATIGUE AND ON MEDIATIONAL RELATIONSHIPS BETWEEN CHANGES IN SLEEP AND CANCER-RELATED FATIGUE: A NATIONWIDE, MULTICENTER RANDOMIZED CONTROLLED TRIAL OF YOGA IN CANCER SURVIVORS. BACKGROUND: CANCER-RELATED FATIGUE (CRF) OFTEN CO-OCCURS WITH SLEEP DISTURBANCE AND IS ONE OF THE MOST PERVASIVE TOXICITIES RESULTING FROM CANCER AND ITS TREATMENT. WE AND OTHER INVESTIGATORS HAVE PREVIOUSLY REPORTED THAT YOGA THERAPY CAN IMPROVE SLEEP QUALITY IN CANCER PATIENTS AND SURVIVORS. NO NATIONWIDE MULTICENTER PHASE III RANDOMIZED CONTROLLED TRIAL (RCT) HAS INVESTIGATED WHETHER YOGA THERAPY IMPROVES CRF OR WHETHER IMPROVEMENTS IN SLEEP MEDIATE THE EFFECT OF YOGA ON CRF. WE EXAMINED THE EFFECT OF A STANDARDIZED, 4-WEEK, YOGA THERAPY PROGRAM (YOGA FOR CANCER SURVIVORS [YOCAS]) ON CRF AND WHETHER YOCAS-INDUCED CHANGES IN SLEEP MEDIATED CHANGES IN CRF AMONG SURVIVORS. STUDY DESIGN AND METHODS: FOUR HUNDRED TEN CANCER SURVIVORS WERE RECRUITED TO A NATIONWIDE MULTICENTER PHASE III RCT COMPARING THE EFFECT OF YOCAS TO STANDARD SURVIVORSHIP CARE ON CRF AND EXAMINING THE MEDIATING EFFECTS OF CHANGES IN SLEEP, STEMMING FROM YOGA, ON CHANGES IN CRF. CRF WAS ASSESSED BY THE MULTIDIMENSIONAL FATIGUE SYMPTOM INVENTORY. SLEEP WAS ASSESSED VIA THE PITTSBURGH SLEEP QUALITY INDEX. BETWEEN- AND WITHIN-GROUP INTERVENTION EFFECTS ON CRF WERE ASSESSED BY ANALYSIS OF COVARIANCE AND 2-TAILED T TEST, RESPECTIVELY. PATH ANALYSIS WAS USED TO EVALUATE MEDIATION. RESULTS: YOCAS PARTICIPANTS DEMONSTRATED SIGNIFICANTLY GREATER IMPROVEMENTS IN CRF COMPARED WITH PARTICIPANTS IN STANDARD SURVIVORSHIP CARE AT POST-INTERVENTION ( P < .01). IMPROVEMENTS IN OVERALL SLEEP QUALITY AND REDUCTIONS IN DAYTIME DYSFUNCTION (EG, EXCESSIVE NAPPING) RESULTING FROM YOGA SIGNIFICANTLY MEDIATED THE EFFECT OF YOGA ON CRF (22% AND 37%, RESPECTIVELY, BOTH P < .01). CONCLUSIONS: YOCAS IS EFFECTIVE FOR TREATING CRF AMONG CANCER SURVIVORS; 22% TO 37% OF THE IMPROVEMENTS IN CRF FROM YOGA THERAPY RESULT FROM IMPROVEMENTS IN SLEEP QUALITY AND DAYTIME DYSFUNCTION. ONCOLOGISTS SHOULD CONSIDER PRESCRIBING YOGA TO CANCER SURVIVORS FOR TREATING CRF AND SLEEP DISTURBANCE.	2019	
                                                                                                                                         
6   70  41 A FEASIBILITY STUDY EXAMINING THE IMPACT OF YOGA ON PSYCHOSOCIAL HEALTH AND SYMPTOMS IN PEDIATRIC OUTPATIENTS RECEIVING CHEMOTHERAPY. PURPOSE: PEDIATRIC CANCER PATIENTS EXPERIENCE SYMPTOMS THAT NEGATIVELY IMPACT QUALITY OF LIFE; YOGA MAY BE AN EFFECTIVE INTERVENTION. THE PRIMARY OBJECTIVE WAS TO DETERMINE THE FEASIBILITY OF A 10-WEEK, WEEKLY INDIVIDUALIZED YOGA INTERVENTION FOR CHILDREN AND ADOLESCENTS RECEIVING OUTPATIENT CANCER THERAPY PRIMARILY DELIVERED REMOTELY USING SKYPE. SECONDARY OBJECTIVES WERE TO DESCRIBE DEPRESSION, ANXIETY, ANGER, FATIGUE, QUALITY OF LIFE, AND SYMPTOMS AT 5 AND 10 WEEKS AFTER ENROLLMENT. METHODS: WE INCLUDED ENGLISH-SPEAKING PATIENTS AGED 10 TO 18 YEARS RECEIVING OUTPATIENT CHEMOTHERAPY FOR CANCER. WEEKLY INDIVIDUALIZED YOGA SESSIONS WERE OFFERED FOR 10 WEEKS. WEEKS 1, 5, AND 10 WERE IN-HOSPITAL WHILE THE REMAINING SESSIONS WERE DELIVERED REMOTELY USING SKYPE. TWICE WEEKLY, HOMEWORK WAS ASSIGNED BETWEEN EACH SESSION. THE PRIMARY OUTCOME WAS FEASIBILITY, DEFINED AS 80% OF PARTICIPANTS COMPLETING AT LEAST 60% OF PLANNED IN-HOSPITAL OR REMOTE YOGA SESSIONS. RESULTS: BETWEEN MARCH AND NOVEMBER 2017, 10 PATIENTS WERE ENROLLED. TWO PATIENTS DISCONTINUED THE STUDY AFTER ONE AND TWO SESSIONS. ONLY SIX PARTICIPANTS ACHIEVED AT LEAST 60% OF PLANNED YOGA SESSIONS AND THUS, THE STUDY DID NOT MEET THE A PRIORI DEFINED FEASIBILITY THRESHOLD. AMONG ALL PARTICIPANTS, ONLY ONE HOMEWORK SESSION WAS PERFORMED. CONCLUSIONS: A 10-WEEK INDIVIDUALIZED IN-PERSON AND REMOTELY CONDUCTED YOGA INTERVENTION WAS NOT FEASIBLE IN CHILDREN RECEIVING CANCER TREATMENTS BECAUSE OF FAILURE TO ACHIEVE THE DESIRED FREQUENCY OF YOGA SESSIONS IN A SUFFICIENT NUMBER OF PARTICIPANTS. FUTURE RESEARCH SHOULD IDENTIFY APPROACHES TO IMPROVE COMPLIANCE WITH REMOTE YOGA SESSIONS AND HOME PRACTICE. TRIAL REGISTRATION: NCT03318068.	2019	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
7  551  34 CONVENIENT AND LIVE MOVEMENT (CALM) FOR WOMEN UNDERGOING BREAST CANCER TREATMENT: CHALLENGES AND RECOMMENDATIONS FOR INTERNET-BASED YOGA RESEARCH. OBJECTIVE: TO CONDUCT A PILOT TRIAL OF INTERNET-BASED, CANCER-ADAPTED YOGA FOR WOMEN RECEIVING BREAST CANCER TREATMENT. DESIGN: WOMEN UNDERGOING RADIATION OR CHEMOTHERAPY FOR BREAST CANCER WERE RECRUITED FOR 12, 75-MIN, BIWEEKLY, CANCER-ADAPTED YOGA CLASSES DELIVERED VIA INTERNET-BASED, MULTIPOINT VIDEOCONFERENCING. DATA WERE COLLECTED ON FEASIBILITY AND ACCEPTABILITY, INCLUDING QUALITATIVE FEEDBACK FROM PARTICIPANTS AND THE YOGA INSTRUCTOR. RESULTS: AMONG 42 WOMEN APPROACHED, 13 DECLINED ELIGIBILITY SCREENING, AND 23 WERE INELIGIBLE. ALL 6 WOMEN WHO WERE ELIGIBLE PROVIDED CONSENT, BUT 2 WITHDREW PRIOR TO BEGINNING YOGA CLASSES. THE REMAINING 4 PARTICIPANTS ATTENDED 1-11 OF 12 ONLINE YOGA CLASSES. IN POST-INTERVENTION INTERVIEWS, PARTICIPANTS AND THE INSTRUCTOR AGREED THAT INTERNET-BASED YOGA CLASSES HOLD GREAT POTENTIAL FOR INCREASING ACCESS AND IMPROVING PSYCHOLOGICAL OUTCOMES IN ADULTS WITH CANCER. QUALITATIVE FEEDBACK FROM PARTICIPANTS REVEALED SUGGESTIONS FOR FUTURE TRIALS OF INTERNET-BASED, CANCER-ADAPTED YOGA CLASSES, INCLUDING: CONTINUED USE OF GROUP FORMAT; OFFERING MORE VARIED CLASS TIMES TO ACCOMMODATE PATIENTS' DEMANDING SCHEDULES AND FLUCTUATING SYMPTOMS; ENROLLING PATIENTS AFTER THEY HAVE ACCLIMATED TO OR COMPLETED CANCER TREATMENT; STREAMLINING THE TECHNOLOGY INTERFACE; AND CAREFUL ATTENTION TO PARTICIPANT BURDEN WHEN DESIGNING SURVEYS/FORMS. THE INSTRUCTOR RECOMMENDED CLOSED SESSION COURSES, AS OPPOSED TO ROLLING ENROLLMENT; TEACHING THE SAME MODIFIED POSES FOR ALL PARTICIPANTS, RATHER THAN INDIVIDUAL TAILORING; AND USING A LARGE SCREEN TO ALLOW CLOSER MONITORING OF STUDENTS' CLASS EXPERIENCE. CONCLUSIONS: INTERNET DELIVERY MAY INCREASE PATIENTS' ACCESS TO CANCER-ADAPTED YOGA CLASSES, BUT CANCER-RELATED AND TECHNOLOGICAL BARRIERS REMAIN. THIS STUDY INFORMS HOW TO OPTIMALLY DESIGN YOGA CLASSES, TECHNOLOGY, AND RESEARCH PROCEDURES TO MAXIMIZE FEASIBILITY AND ACCEPTABILITY IN FUTURE TRIALS.	2018	
                                                                                                                                                                                                                        
8 1240  43 FEASIBILITY OF A MINDFUL YOGA PROGRAM FOR WOMEN WITH METASTATIC BREAST CANCER: RESULTS OF A RANDOMIZED PILOT STUDY. PURPOSE: PATIENTS WITH METASTATIC BREAST CANCER (MBC) EXPERIENCE HIGH LEVELS OF SYMPTOMS. YOGA INTERVENTIONS HAVE SHOWN PROMISE FOR IMPROVING CANCER SYMPTOMS BUT HAVE RARELY BEEN TESTED IN PATIENTS WITH ADVANCED DISEASE. THIS STUDY EXAMINED THE ACCEPTABILITY OF A COMPREHENSIVE YOGA PROGRAM FOR MBC AND THE FEASIBILITY OF CONDUCTING A RANDOMIZED TRIAL TESTING THE INTERVENTION. METHODS: SIXTY-THREE WOMEN WITH MBC WERE RANDOMIZED WITH A 2:1 ALLOCATION TO YOGA OR A SUPPORT GROUP COMPARISON CONDITION. BOTH INTERVENTIONS INVOLVED EIGHT WEEKLY GROUP SESSIONS. FEASIBILITY WAS QUANTIFIED USING RATES OF ACCRUAL, ATTRITION, AND SESSION ATTENDANCE. ACCEPTABILITY WAS ASSESSED WITH A STANDARDIZED SELF-REPORT MEASURE. PAIN, FATIGUE, SLEEP QUALITY, PSYCHOLOGICAL DISTRESS, MINDFULNESS, AND FUNCTIONAL CAPACITY WERE ASSESSED AT BASELINE, POST-INTERVENTION, AND 3 AND 6 MONTHS POST-INTERVENTION. RESULTS: WE MET GOALS FOR ACCRUAL AND RETENTION, WITH 50% OF ELIGIBLE PATIENTS ENROLLED AND 87% OF RANDOMIZED PARTICIPANTS COMPLETING POST-INTERVENTION SURVEYS. SIXTY-FIVE PERCENT OF WOMEN IN THE YOGA CONDITION AND 90% IN THE SUPPORT GROUP ATTENDED >/= 4 SESSIONS. EIGHTY PERCENT OF PARTICIPANTS IN THE YOGA CONDITION AND 65% IN THE SUPPORT GROUP INDICATED THAT THEY WERE HIGHLY SATISFIED WITH THE INTERVENTION. FOLLOWING TREATMENT, WOMEN IN THE YOGA INTERVENTION HAD MODEST IMPROVEMENTS IN SOME OUTCOMES; HOWEVER, OVERALL SYMPTOM LEVELS WERE LOW FOR WOMEN IN BOTH CONDITIONS. CONCLUSIONS: FINDINGS SUGGEST THAT THE YOGA INTERVENTION CONTENT WAS HIGHLY ACCEPTABLE TO PATIENTS WITH MBC, BUT THAT THERE ARE CHALLENGES TO IMPLEMENTING AN INTERVENTION INVOLVING EIGHT GROUP-BASED IN-PERSON SESSIONS. ALTERNATIVE MODES OF DELIVERY MAY BE NECESSARY TO REACH PATIENTS MOST IN NEED OF INTERVENTION.	2019	
                                                                                                                                                                                                                                                                                                                                                                                                                      
9  608  40 DEVELOPMENT OF A FALLS REDUCTION YOGA PROGRAM FOR OLDER ADULTS-A PILOT STUDY. OBJECTIVES: WORK WITH LOCAL RURAL ORGANIZATIONS TO DEVELOP AN EVIDENCE-BASED HATHA YOGA PROGRAM INTENDED TO IMPROVE CORE STRENGTH AND BALANCE TO REDUCE FALLS RISK. FEASIBILITY DETERMINED BY SUCCESSFUL RECRUITING, INTERVENTION AND EVALUATION OF PARTICIPANTS AND ACCEPTABLE FREQUENCY OF ADVERSE EVENTS. DESIGN: SINGLE-ARM PILOT STUDY. SETTING: RURAL WISCONSIN TOWN OF 4200 PEOPLE. INTERVENTION: EIGHT WEEK YOGA PROGRAM WITH WEEKLY GROUP CLASSES AND HOME YOGA PRACTICE THREE TIMES PER WEEK. MAIN OUTCOME MEASURES: THE PRIMARY OUTCOMES WERE (1) ABILITY TO ENROLL AT LEAST 20 PARTICIPANTS, (2) PARTICIPANT COMPLETION OF INTERVENTION AND POST-INTERVENTION EVALUATION, AND (3) ADVERSE EVENT DESCRIPTION AND FREQUENCY. RESULTS: A CONVENIENCE SAMPLE OF 20 ADULTS OVER AGE 59 WAS ENROLLED AND STARTED THE PROGRAM WITH ONE DROP OUT. PARTICIPANTS ATTENDED A MEAN OF 7.1 (SD 1.47) OF THE 8 CLASSES AND A TOTAL OF 141 OUT OF 160 (88.1%) CLASSES. NINETEEN (95%) COMPLETED FOLLOW UP EVALUATION. PARTICIPANTS REPORTED 4 FALLS IN THE MONTH BEFORE THE INTERVENTION AND 1 FALL THE MONTH BEFORE THE POST-INTERVENTION EVALUATION (P=0.34). NO OTHER SERIOUS ADVERSE EVENTS OCCURRED. CONCLUSIONS: THIS PROJECT SUGGESTS AN EVIDENCE-BASED YOGA PROGRAM DESIGNED TO IMPROVE CORE STRENGTH AND BALANCE IS FEASIBLE AND ACCEPTABLE TO PARTICIPANTS. FUTURE RESEARCH WILL INCLUDE A RANDOMIZED TRIAL TO ASSESS IMPACT ON FALLS RISK.	2017	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
10   41  40 A BRIEF YOGA INTERVENTION IMPLEMENTED DURING CHEMOTHERAPY: A RANDOMIZED CONTROLLED PILOT STUDY. OBJECTIVES: FATIGUE AND OTHER TREATMENT-RELATED SYMPTOMS (E.G., SLEEP DISTURBANCE) ARE CRITICAL TARGETS FOR IMPROVING QUALITY OF LIFE IN PATIENTS UNDERGOING CHEMOTHERAPY. YOGA MAY REDUCE THE BURDEN OF SUCH SYMPTOMS. THIS STUDY INVESTIGATED THE FEASIBILITY OF CONDUCTING A RANDOMIZED CONTROLLED STUDY OF A BRIEF YOGA INTERVENTION DURING CHEMOTHERAPY FOR COLORECTAL CANCER. DESIGN: WE RANDOMIZED ADULTS WITH COLORECTAL CANCER TO A BRIEF YOGA SKILLS TRAINING (YST) OR AN ATTENTION CONTROL (AC; EMPATHIC ATTENTION AND RECORDED EDUCATION). SETTING: THE INTERVENTIONS AND ASSESSMENTS WERE IMPLEMENTED INDIVIDUALLY IN THE CLINIC WHILE PATIENTS WERE IN THE CHAIR RECEIVING CHEMOTHERAPY. INTERVENTIONS: BOTH INTERVENTIONS CONSISTED OF THREE SESSIONS AND RECOMMENDED HOME PRACTICE. MAIN OUTCOME MEASURES: THE PRIMARY OUTCOME WAS FEASIBILITY (ACCRUAL, RETENTION, ADHERENCE, DATA COLLECTION). SELF-REPORTED OUTCOMES (I.E., FATIGUE, SLEEP DISTURBANCE, QUALITY OF LIFE) AND INFLAMMATORY BIOMARKERS WERE ALSO DESCRIBED TO INFORM FUTURE STUDIES. RESULTS: OF 52 PATIENTS INITIALLY IDENTIFIED, 28 WERE APPROACHED, AND 15 ENROLLED (AGE MEAN = 57.5 YEARS; 80% WHITE; 60% MALE). REASONS FOR DECLINING PARTICIPATION WERE: NOT INTERESTED (N = 6), DID NOT PERCEIVE A NEED (N = 2), AND OTHER (N = 5). TWO PARTICIPANTS WERE LOST TO FOLLOW-UP IN EACH GROUP DUE TO TREATMENT CHANGES. THUS, 75% OF PARTICIPANTS WERE RETAINED IN THE YST AND 71% IN THE AC ARM. PARTICIPANTS RETAINED IN THE STUDY ADHERED TO 97% OF THE IN-PERSON INTERVENTION SESSIONS AND COMPLETED ALL QUESTIONNAIRES. CONCLUSIONS: THIS STUDY DEMONSTRATED THE FEASIBILITY OF CONDUCTING A LARGER RANDOMIZED CONTROLLED TRIAL TO ASSESS YST AMONG PATIENTS RECEIVING CHEMOTHERAPY FOR COLORECTAL CANCER. DATA COLLECTED AND CHALLENGES ENCOUNTERED WILL INFORM FUTURE RESEARCH.	2016	
                                                                                                                                                                                                                                                                                                                                                                                                                
11  206  39 A SELF-DIRECTED HOME YOGA PROGRAMME FOR WOMEN WITH BREAST CANCER DURING CHEMOTHERAPY: A FEASIBILITY STUDY. RECENT STUDIES SUGGEST YOGA AS A PROMISING APPROACH FOR IMPROVING THE COGNITIVE FUNCTION OF CANCER SURVIVORS. WE STUDIED WHETHER A SELF-DIRECTED HOME YOGA PROGRAMME WAS FEASIBLE FOR PATIENTS WITH BREAST CANCER WHO WERE UNDERGOING CHEMOTHERAPY. PARTICIPANTS' PREFERENCES FOR THE TYPE OF YOGA COURSE AND THE CLINICAL EFFECTS OF THE PROGRAMME WERE ALSO ASSESSED. IN THIS STUDY, 18 WOMEN (MEAN AGE, 43.9 YEARS) WERE ENROLLED (44.7% RECRUITMENT RATE). OF THE PARTICIPANTS, 63.6% HAD STAGE II CANCER AND 71.4% RECEIVED ADJUVANT CHEMOTHERAPY. FAVOURABLE RETENTION (86%), ADHERENCE (94.4%) AND ACCEPTABILITY (96.5%) RATES WERE DETERMINED. MOST (94.4%) OF THE WOMEN PRACTICED THE HOME PROGRAMME MORE THAN TWICE A WEEK ON AVERAGE. THE PARTICIPANTS PREFERRED TO GRADUALLY INCREASE THE INTENSITY OF THE EXERCISES. WE ONLY OBSERVED IMPROVEMENTS IN THE COGNITIVE ASPECTS OF FATIGUE. NO SERIOUS ADVERSE EVENTS WERE ENCOUNTERED DURING THE PROGRAMME. THIS SELF-DIRECTED HOME YOGA PROGRAMME WAS SAFE AND FEASIBLE FOR PATIENTS WITH BREAST CANCER UNDERGOING CHEMOTHERAPY.	2016	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
12 2557  38 YOGA FOR CHRONIC CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY PAIN: A PILOT, RANDOMIZED CONTROLLED TRIAL. PURPOSE: TO DETERMINE THE FEASIBILITY OF IMPLEMENTING A YOGA INTERVENTION FOR CANCER SURVIVORS WITH CHRONIC CIPN PAIN, AS WELL AS THE IMPACT OF THE INTERVENTION ON PATIENT-REPORTED OUTCOMES. METHODS: CANCER SURVIVORS WITH CHRONIC CIPN PAIN WERE RECRUITED FROM THE BREAST, GASTROINTESTINAL, AND GYNECOLOGICAL ONCOLOGY CENTERS AT DANA-FARBER CANCER INSTITUTE. PARTICIPANTS WERE RANDOMIZED (2:1) TO RECEIVE AN 8-WEEK YOGA INTERVENTION OR USUAL CARE. AFTER 21/50 OF PARTICIPANTS WERE ENROLLED, THE COVID-19 PANDEMIC REQUIRED THE YOGA INTERVENTION TO BE DELIVERED VIRTUALLY (I.E., ZOOM). PRE- AND POST-INTERVENTION, PARTICIPANTS SELF-REPORTED CIPN AND CO-OCCURRING SYMPTOM SEVERITY. ADHERENCE TO THE INTERVENTION WAS DEFINED AS PRACTICING >/= 12 YOGA SESSIONS OVER THE 8-WEEK INTERVENTION PERIOD. CHANGES IN PATIENT-REPORTED OUTCOMES BETWEEN GROUPS WERE COMPARED USING WILCOXON'S RANK-SUM TESTS. RESULTS: PARTICIPANTS (N = 28 YOGA, N = 16 CONTROL) WERE MAINLY FEMALE (96%) AND DIAGNOSED WITH STAGE III/IV DISEASE (66%). OVERALL, 19/28 (67.8%) OF YOGA GROUP PARTICIPANTS WERE ADHERENT TO THE YOGA PROTOCOL. YOGA GROUP PARTICIPANTS EXPERIENCED SIGNIFICANT WITHIN-GROUP IMPROVEMENTS IN ALL PATIENT-REPORTED OUTCOMES, INCLUDING WORST CIPN PAIN (MEDIAN CHANGE = - 1.7, P < 0.0001) AND SENSORY CIPN (MEDIAN CHANGE = - 14.8, P < 0.0001), BUT ONLY IMPROVEMENTS IN FATIGUE (P = 0.05) AND DEPRESSION (P = 0.04) WERE SIGNIFICANT COMPARED TO THE CONTROL. THERE WERE NO DIFFERENCES (P > 0.05) IN CHANGES IN PATIENT-REPORTED OUTCOMES BETWEEN IN-PERSON (N = 6) OR VIRTUAL (N = 15) YOGA GROUP PARTICIPANTS. CONCLUSIONS: YOGA IS A FEASIBLE NON-PHARMACOLOGICAL MODALITY FOR CANCER SURVIVORS WITH CIPN, BUT MORE INFORMATION IS NEEDED REGARDING ITS IMPACT ON CIPN AND OTHER SYMPTOMS. TRIAL REGISTRATION: CLINICALTRIALS.GOV IDENTIFIER: NCT03824860 IMPLICATIONS FOR CANCER SURVIVORS: ONCOLOGY CLINICIANS MAY CONSIDER REFERRING CANCER SURVIVORS TO YOGA FOR CHRONIC CIPN PAIN, BUT YOGA CANNOT BE CURRENTLY RECOMMENDED AS AN EFFICACIOUS TREATMENT.	2021	
                                                                                                                                                                                 
13 1331  47 HOME-BASED YOGA PROGRAM FOR THE PATIENTS SUFFERING FROM MALIGNANT LYMPHOMA DURING CHEMOTHERAPY: A FEASIBILITY STUDY. BACKGROUND: YOGA IS PROVEN BENEFICIAL IN IMPROVING QUALITY OF LIFE AMONG BREAST CANCER SURVIVORS RECEIVING CHEMOTHERAPY, BUT ITS EFFECTIVENESS IN LYMPHOMA PATIENTS NEEDS TO BE EXPLORED. AS CHEMOTHERAPY-INDUCED NEUTROPENIA IS VERY COMMON AMONG LYMPHOMA PATIENTS, THEY ARE MUCH PRONE TO INFECTIONS FROM THE ENVIRONMENT. FURTHERMORE, TRAINED YOGA INSTRUCTORS ARE NOT AVAILABLE IN EVERY SETTING, SO THERE IS A NEED TO DEVELOP HOME-BASED YOGA PROGRAM MODULES FOR LYMPHOMA PATIENTS RECEIVING CHEMOTHERAPY. AIM: THE AIM OF THE STUDY WAS TO EXPLORE THE FEASIBILITY AND SAFETY OF YOGIC EXERCISES AMONG LYMPHOMA PATIENTS DURING CHEMOTHERAPY. SUBJECTS AND METHODS: AN INTERVENTIONAL, SINGLE-ARM PREPOST DESIGN STUDY WAS CONDUCTED AT A TERTIARY HEALTH-CARE CENTER. PATIENTS SUFFERING FROM MALIGNANT LYMPHOMA (18-65 YEARS) WITH EASTERN COOPERATIVE ONCOLOGY GROUP PERFORMANCE STATUS FROM 0 TO 2, PLANNED TO RECEIVE CHEMOTHERAPY WERE ADMINISTERED A HOME-BASED YOGA PROGRAM OVER A PERIOD OF 2 MONTHS FROM THE START OF CHEMOTHERAPY. THE PRIMARY OUTCOME VARIABLES WERE RETENTION RATE, ACCEPTANCE RATE, SAFETY, AND ADHERENCE. HEALTH-RELATED QUALITY OF LIFE (HRQOL), FATIGUE LEVEL, OVERALL SLEEP QUALITY, DEPRESSION, ANXIETY LEVEL, AND PAIN WERE ALSO ASSESSED. STATISTICAL ANALYSIS: DESCRIPTIVE STATISTICS WAS USED TO SEE THE FEASIBILITY AND ADHERENCE. THE PAIRED T-TEST WAS USED TO COMPARE VARIOUS PRE AND POSTINTERVENTION OUTCOME MEASURES. RESULTS: FOURTEEN PATIENTS (MEDIAN AGE: 36 YEARS, RANGE13-65 YEARS) OF MALIGNANT LYMPHOMA WERE ENROLLED IN THE STUDY. MALE-TO-FEMALE RATIO WAS 9:5. NON-HODGKIN'S LYMPHOMA PATIENTS CONSTITUTED 64%. THE RECRUITMENT RATE WAS 93%. FAVORABLE RETENTION (100%), ACCEPTABILITY (97%), ADHERENCE (78.6%), AND NO SERIOUS ADVERSE EVENTS FOLLOWING YOGA PRACTICE WERE REPORTED. IMPROVEMENT WAS ALSO FOUND IN HRQOL, FATIGUE, SLEEP, DEPRESSION, AND ANXIETY. HOWEVER, IT NEEDS FURTHER VALIDATION IN A RANDOMIZED STUDY. CONCLUSION: HOME-BASED YOGA PROGRAM IS SAFE AND FEASIBLE AMONG THE PATIENTS SUFFERING FROM MALIGNANT LYMPHOMA RECEIVING CHEMOTHERAPY.	2018	
                                                                                                                            
14   71  35 A FEASIBILITY STUDY OF RESTORATIVE YOGA VERSUS VIGOROUS YOGA INTERVENTION FOR SEDENTARY BREAST AND OVARIAN CANCER SURVIVORS. YOGA HAS BEEN SHOWN TO IMPROVE CANCER SURVIVORS' QUALITY OF LIFE, YET REGULAR YOGA PRACTICE IS A CHALLENGE FOR THOSE WHO ARE SEDENTARY. WE CONDUCTED A PILOT RANDOMIZED CONTROLLED STUDY TO ASSESS FEASIBILITY AND ADHERENCE OF TWO TYPES OF YOGA INTERVENTION AMONG SEDENTARY CANCER SURVIVORS. SEDENTARY BREAST AND OVARIAN CANCER SURVIVORS WERE RANDOMIZED TO PRACTICE EITHER RESTORATIVE YOGA (MINIMAL PHYSICAL EXERTION, GROUP R) OR VIGOROUS YOGA (CONSIDERABLE PHYSICAL EXERTION, GROUP V) IN THREE 60-MINUTE SUPERVISED SESSIONS A WEEK FOR 12 WEEKS, FOLLOWED BY 12 WEEKS OF HOME PRACTICE. ACCRUAL, ADHERENCE, AND ATTENDANCE RATES WERE ASSESSED. OF THE 226 ELIGIBLE PATIENTS, 175 (77%) DECLINED TO PARTICIPATE IN THE STUDY, CITING TIME COMMITMENT AND TRAVEL AS THE MOST COMMON BARRIERS. FORTY-TWO SUBJECTS CONSENTED TO PARTICIPATE IN THE STUDY. OF THE 35 PARTICIPANTS WHO BEGAN THE INTERVENTION (20 IN GROUP R AND 15 IN GROUP V), ADHERENCE RATE (PERCENTAGE REMAINING IN THE STUDY AT WEEK 12) WAS 100% AND 87%, RESPECTIVELY. RATE OF ADEQUATE ATTENDANCE (MORE THAN 66% OF THE SCHEDULED SUPERVISED SESSIONS) WAS 85% AND 73%, RESPECTIVELY. RATE OF COMPLETION OF THE HOME PRACTICE PERIOD WAS 85% AND 77%, RESPECTIVELY. IN THIS STUDY, SEDENTARY CANCER SURVIVORS WERE ABLE TO ADHERE TO A LONG-TERM, REGULAR YOGA REGIMEN. THE RATE OF ADEQUATE ATTENDANCE WAS HIGHER FOR RESTORATIVE YOGA. FUTURE STUDIES FOR SEDENTARY PATIENTS SHOULD FOCUS ON REDUCING TIME COMMITMENT AND TRAVEL REQUIREMENTS TO IMPROVE RECRUITMENT, AND ON USING RESTORATIVE YOGA AS A MORE FEASIBLE INTERVENTION FOR THIS POPULATION.	2018	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
15  478  42 CLINICAL CASE REPORT: YOGA FOR FATIGUE IN FIVE YOUNG ADULT SURVIVORS OF CHILDHOOD CANCER. PURPOSE: CANCER-RELATED FATIGUE (CRF) IS A DISTRESSING CONSEQUENCE OF CANCER AND ITS TREATMENT. CRF IMPACTS MANY YOUNG ADULT (YA) SURVIVORS OF CHILDHOOD CANCER, COMPROMISING WORK, SOCIAL RELATIONSHIPS, AND DAILY ACTIVITIES. NO SATISFACTORY TREATMENT EXISTS. THIS PILOT STUDY AIMED TO ASSESS THE FEASIBILITY, SAFETY, AND PRELIMINARY EFFICACY OF AN 8-WEEK TWICE/WEEK IYENGAR YOGA (IY) INTERVENTION FOR TREATING PERSISTENT FATIGUE IN YA SURVIVORS OF CHILDHOOD CANCER. METHODS: USING A SINGLE-ARM MIXED-METHODS DESIGN, ADULT CHILDHOOD CANCER SURVIVORS AGED BETWEEN 18 AND 39 YEARS WERE RECRUITED FROM A SURVIVORSHIP CLINIC AT A SINGLE INSTITUTION. QUANTITATIVE: THE PRIMARY OUTCOME WAS FATIGUE AS MEASURED BY THE FUNCTIONAL ASSESSMENT OF CHRONIC ILLNESS THERAPY-FATIGUE. SECONDARY OUTCOMES INCLUDED VITALITY, SOCIAL FUNCTIONING, MULTIDIMENSIONAL FATIGUE, MOOD, AND SLEEP. WEEKLY SELF-REPORT MONITORING DATA WERE COLLECTED. QUALITATIVE: PARTICIPANTS ALSO COMPLETED A POST-INTERVENTION INTERVIEW, MAJOR THEMES EVALUATED. RESULTS: FIVE PARTICIPANTS ENROLLED INTO THE STUDY AND FOUR COMPLETED THE INTERVENTION. ATTENDANCE WAS 92% AND THERE WERE NO ADVERSE EVENTS. BASELINE MOBILITY WAS HIGHLY VARIED, WITH ONE YA HAVING HAD A HEMIPELVECTOMY. QUANTITATIVE DATA REVEALED SIGNIFICANTLY IMPROVED FATIGUE, SOCIAL FUNCTIONING, SOMATIZATION, AND GENERAL AND EMOTIONAL MANIFESTATIONS OF FATIGUE FOLLOWING YOGA. QUALITATIVE DATA CROSS VALIDATED, CLARIFIED, AND EXPANDED UPON THE QUANTITATIVE FINDINGS. CONCLUSIONS: THE STUDY SUGGESTS THAT A BRIEF IY INTERVENTION IS SAFE FOR YA SURVIVORS OF CHILDHOOD CANCER, EVEN FOR THOSE WITH PHYSICAL DISABILITIES. PRELIMINARY EFFICACY WAS DEMONSTRATED FOR THE PRIMARY OUTCOME OF FATIGUE. QUALITATIVE DATA ELUCIDATED ADDITIONAL IMPROVEMENTS, SUCH AS WORK-RELATED SOCIAL FUNCTIONING, AND A SENSE OF CALM AND RELAXATION.	2017	
                                                                                                                                                                                                                                                                                                                                                                                  
16 1237  43 FEASIBILITY OF A BRIEF YOGA INTERVENTION FOR IMPROVING ACUTE PAIN AND DISTRESS POST GYNECOLOGIC SURGERY. BACKGROUND: WOMEN UNDERGOING SURGICAL PROCEDURES FOR SUSPECTED GYNECOLOGIC MALIGNANCIES FREQUENTLY EXPERIENCE PAIN AND PSYCHOLOGICAL DISTRESS RELATED TO SURGERY. YOGA MAY REDUCE THESE NEGATIVE SURGICAL OUTCOMES. THE PRIMARY OBJECTIVE OF THIS PILOT STUDY WAS TO ASSESS THE FEASIBILITY OF EVALUATING A PERIOPERATIVE BRIEF YOGA SKILLS TRAINING (YST) IN THIS POPULATION. SECONDARY OBJECTIVES WERE TO (1) ASSESS THE IMMEDIATE EFFECTS OF THE YST ON PAIN AND PSYCHOLOGICAL DISTRESS; AND (2) PROVIDE PRELIMINARY DATA FOR FUTURE STUDIES. METHOD: ADULT WOMEN SCHEDULED TO UNDERGO AN EXPLORATORY LAPAROTOMY FOR A SUSPECTED GYNECOLOGIC MALIGNANCY WERE RECRUITED TO THIS ONE-ARM FEASIBILITY STUDY. EACH WOMAN RECEIVED THE YST, WHICH CONSISTED OF THREE 15-MINUTE SESSIONS, ONE BEFORE AND TWO AFTER SURGERY. THE FOLLOWING CONSTRUCTS WERE ASSESSED: FEASIBILITY (RATES OF ACCRUAL, INTERVENTION ADHERENCE, MEASURE COMPLETION, RETENTION, AND LEVEL OF SATISFACTION), IMMEDIATE EFFECTS OF THE YST (VISUAL ANALOGUE SCALE RATINGS OF PAIN AND DISTRESS IMMEDIATELY BEFORE AND AFTER EACH SESSION), AND DESCRIPTIVE STATISTICS FOR MEASURES TO BE USED IN FUTURE STUDIES. RESULTS: OF THE 33 ELIGIBLE WOMEN, 18 WERE APPROACHED AND 10 AGREED TO PARTICIPATE (MEAN AGE = 54.7 YEARS; 90% WHITE). TWO WOMEN DISCONTINUED THE STUDY PRIOR TO STARTING THE YST SESSIONS. OF THE EIGHT PARTICIPANTS WHO RECEIVED THE YST, FIVE COMPLETED THE PRE-SURGERY SESSION (63%) AND SEVEN COMPLETED (88%) BOTH POST-SURGICAL SESSIONS; ONE WOMAN WITHDREW AFTER ONE YST SESSION. PARTICIPANTS REPORTED HIGH SATISFACTION WITH THE YST. ACUTE PAIN AND DISTRESS DECREASED FROM BEFORE TO IMMEDIATELY AFTER THE YST SESSION WITH MODERATE TO LARGE EFFECTS: PAIN, D'S = -0.67 TO -0.95; DISTRESS, D'S = -0.66 TO -1.08. CONCLUSIONS: THIS STUDY DEMONSTRATED REASONABLE INDICATORS OF FEASIBILITY. IN ADDITION, PATIENTS SHOWED SHORT-TERM REDUCTIONS IN PAIN AND DISTRESS. NEXT STEPS INCLUDE ATTENTION TO IMPROVING STAFF AVAILABILITY AND INTERVENTION IMPLEMENTATION IN ORDER TO FEASIBLY EVALUATE THE PERIOPERATIVE YST, WHICH SHOWS PROMISE FOR REDUCING POSTOPERATIVE PAIN AND DISTRESS.	2016	
                                                                                     
17 1865  41 RANDOMIZED PILOT TRIAL OF YOGA VERSUS STRENGTHENING EXERCISES IN BREAST CANCER SURVIVORS WITH CANCER-RELATED FATIGUE. PURPOSE: FATIGUE IS ONE OF THE MOST COMMON AND BOTHERSOME REFRACTORY SYMPTOMS EXPERIENCED BY CANCER SURVIVORS. MINDFUL EXERCISE INTERVENTIONS SUCH AS YOGA IMPROVE CANCER-RELATED FATIGUE; HOWEVER, STUDIES OF YOGA HAVE INCLUDED HETEROGENEOUS SURVIVORSHIP POPULATIONS, AND THE EFFECT OF YOGA ON FATIGUED SURVIVORS REMAINS UNCLEAR. METHODS: WE RANDOMLY ASSIGNED 34 EARLY-STAGE BREAST CANCER SURVIVORS WITH CANCER-RELATED FATIGUE (>/=4 ON A LIKERT SCALE FROM 1-10) WITHIN 1 YEAR FROM DIAGNOSIS TO A 12-WEEK INTERVENTION OF HOME-BASED YOGA VERSUS STRENGTHENING EXERCISES, BOTH PRESENTED ON A DVD. THE PRIMARY ENDPOINTS WERE FEASIBILITY AND CHANGES IN FATIGUE, AS MEASURED BY THE MULTIDIMENSIONAL FATIGUE SYMPTOM INVENTORY-SHORT FORM (MFSI-SF). SECONDARY ENDPOINT WAS QUALITY OF LIFE, ASSESSED BY THE FUNCTIONAL ASSESSMENT OF CANCER THERAPIES-BREAST (FACT-B). RESULTS: WE INVITED 401 WOMEN TO PARTICIPATE IN THE STUDY; 78 RESPONDED, AND WE ENROLLED 34. BOTH GROUPS HAD SIGNIFICANT WITHIN-GROUP IMPROVEMENT IN MULTIPLE DOMAINS OF THE FATIGUE AND QUALITY OF LIFE SCORES FROM BASELINE TO POST-INTERVENTION, AND THESE BENEFITS WERE MAINTAINED AT 3 MONTHS POST-INTERVENTION. HOWEVER, THERE WAS NO SIGNIFICANT DIFFERENCE BETWEEN GROUPS IN FATIGUE OR QUALITY OF LIFE AT ANY ASSESSMENT TIME. SIMILARLY, THERE WAS NO DIFFERENCE BETWEEN GROUPS IN ADHERENCE TO THE EXERCISE INTERVENTION. CONCLUSIONS: BOTH DVD-BASED YOGA AND STRENGTHENING EXERCISES DESIGNED FOR CANCER SURVIVORS MAY BE GOOD OPTIONS TO ADDRESS FATIGUE IN BREAST CANCER SURVIVORS. BOTH HAVE REASONABLE UPTAKE, ARE CONVENIENT AND REPRODUCIBLE, AND MAY BE HELPFUL IN DECREASING FATIGUE AND IMPROVING QUALITY OF LIFE IN THE FIRST YEAR POST-DIAGNOSIS IN BREAST CANCER PATIENTS WITH CANCER-RELATED FATIGUE.	2016	
                                                                                                                                                                                                                                                                                                                                                                                                                                                
18 1447  41 INDIVIDUALIZED, SINGLE SESSION YOGA THERAPY TO REDUCE PHYSICAL AND EMOTIONAL SYMPTOMS IN HOSPITALIZED HEMATOLOGICAL CANCER PATIENTS. OBJECTIVE: INPATIENT TREATMENT OF HEMATOLOGICAL CANCER IS AMONG THE MOST PHYSICALLY AND MENTALLY ARDUOUS CANCER TREATMENTS, AND IT IS ASSOCIATED WITH A NUMBER OF COMMON PHYSICAL, EMOTIONAL, AND SOCIAL SYMPTOMS THAT CAN NEGATIVELY AFFECT QUALITY OF LIFE (QOL) FOR YEARS FOLLOWING TREATMENT. WHILE TREATING SYMPTOMS DURING HOSPITALIZATION HOLDS PROMISE FOR IMPROVING LONG-TERM QOL, SUCCESSFUL APPROACHES LIKELY REQUIRE MULTIDISCIPLINARY INTERVENTIONS. IN THIS ARTICLE, WE DESCRIBE A 4-YEAR EFFORT IN PROGRAM ENHANCEMENT THAT INCORPORATED AN ADJUNCTIVE SINGLE YOGA THERAPY SESSION DURING TREATMENT FOR HEMATOLOGICAL MALIGNANCIES. METHODS: HOSPITALIZED PATIENTS RECEIVING TREATMENT FOR HEMATOLOGICAL CANCER (N = 486) WERE PROVIDED A 40-MINUTE INDIVIDUALIZED YOGA THERAPY SESSION. WE EVALUATED FEASIBILITY AND ACCEPTANCE BY QUANTIFYING THE PERCENTAGE OF PATIENTS WHO DISCONTINUED THE YOGA SESSION DUE TO PAIN, DISCOMFORT, OR ANOTHER REASON, AND BY COMPARING THE INTERVENTION POPULATION TO THE DEMOGRAPHIC MAKEUP OF THE UNIT MORE GENERALLY. PATIENT-REPORTED SYMPTOMS WERE OBTAINED BEFORE AND AFTER EACH SESSION, AND WE EVALUATED ACUTE SYMPTOM CHANGE FOR THE ENTIRE SAMPLE AND IN SUBSAMPLES THAT ARE LESS LIKELY TO USE MINDFULNESS-BASED INTERVENTIONS SUCH AS YOGA. RESULTS: THE MAJORITY OF SESSIONS (87%) WERE COMPLETED, AND THE MAJORITY OF UNFINISHED SESSIONS WERE INTERRUPTED BY A MEDICAL PROCEDURE OR BECAUSE THE PATIENT FELL ASLEEP. NO SESSION WAS STOPPED EARLY DUE TO PATIENTS' REPORTED PAIN. SIGNIFICANT DECREASES WERE REPORTED IN ALL SYMPTOMS, WITH THE GREATEST DECREASE IN FATIGUE AND ANXIETY. CONCLUSIONS: YOGA THERAPY WAS A FEASIBLE AND EFFECTIVE NONDRUG ADJUNCT INTERVENTION FOR HOSPITALIZED PATIENTS RECEIVING TREATMENT FOR HEMATOLOGICAL CANCER, INCLUDING BONE MARROW TRANSPLANTATION.	2019	
                                                                                                                                                                                                                                                                                                                                                                                        
19  119  43 A PILOT STUDY OF THE ACCEPTABILITY, FEASIBILITY AND SAFETY OF YOGA FOR CHRONIC PAIN IN SICKLE CELL DISEASE. OBJECTIVES: TO DETERMINE THE ACCEPTABILITY, FEASIBILITY AND SAFETY OF YOGA FOR CHRONIC PAIN IN SICKLE CELL DISEASE. DESIGN AND SETTING: IN PART A OF THIS TWO-PART STUDY, ADOLESCENTS WITH SCD AND CHRONIC PAIN (GROUP 1) AND THEIR PARENT (GROUP 2) COMPLETED A SURVEY DESIGNED TO CAPTURE PAIN CHARACTERISTICS, ATTITUDES AND PRACTICES RELATED TO YOGA, AND POTENTIAL ACCEPTABILITY OF A YOGA PROGRAM. IN PART B, THE STUDY ASSESSED THE FEASIBILITY AND SAFETY OF AN INSTRUCTOR-LED GROUP YOGA PROGRAM. THE STUDY WAS REGISTERED ON CLINICALTRIALS.GOV (NCT03694548). INTERVENTION: EIGHT INSTRUCTOR-LED GROUP YOGA SESSIONS. MAIN OUTCOME MEASURES: FEASIBILITY AND SAFETY OUTCOMES WERE CHOSEN A PRIORI, AS FOLLOWS: 1) PROPORTION OF ADOLESCENT PATIENTS WITH SCD AND CHRONIC PAIN APPROACHED THAT CONSENT TO PARTICIPATE IN PART A, 2) PROPORTION OF ADOLESCENT PARTICIPANTS ENROLLED IN PART A THAT CONSENT TO PARTICIPATE IN PART B, 3) PROPORTION OF PARTICIPANTS ENROLLED IN PART B THAT ATTEND AT LEAST 6 OF 8 YOGA SESSIONS, 4) PROPORTION OF PARTICIPANTS ENROLLED IN PART B WITH AN ED VISIT OR A HOSPITALIZATION FOR PAIN WITHIN 24 H OF COMPLETION OF EACH YOGA SESSION, 5) PROPORTION OF PARTICIPANTS IN PART B WHO COMPLETE ALL STUDY ASSESSMENTS BEFORE, AND AT THE END OF THE YOGA PROGRAM, 6) ADHERENCE TO SUBMISSION OF PAIN DIARY. RESULTS: THE MEDIAN AGE OF 15 PATIENT PARTICIPANTS IN PART A WAS 16 (IQR 14-17), AND 14 PARENTS WAS 43.5 (IQR 42-51). MOST PARTICIPANTS WERE FEMALE. MOST PARTICIPANT RESPONSES INDICATED A POSITIVE OPINION OF YOGA. NINE ADOLESCENTS (60 %) FROM PART A PARTICIPATED IN PART B OF THE STUDY. THE MEDIAN AGE OF 9 PARTICIPANTS IN PART B WAS 17 (IQR 15-18), AND 5 OF THE 9 PARTICIPANTS WERE FEMALE (53.3 %). ONLY ONE PARTICIPANT WAS ABLE TO ATTEND 3 OF THE 8 YOGA SESSIONS OFFERED, AND DID NOT EXPERIENCE ANY ED VISITS OR HOSPITALIZATIONS FOLLOWING THE YOGA SESSIONS. NONE OF THE OTHER FEASIBILITY ENDPOINTS WERE MET IN THIS STUDY. CONCLUSIONS: PATIENTS WITH SCD AND CHRONIC PAIN OVERALL HAVE A POSITIVE OPINION OF YOGA, BUT THERE ARE CHALLENGES WITH RECRUITMENT AND RETENTION OF PARTICIPANTS IN A CLINICAL TRIAL OF YOGA, AND BARRIERS TO FEASIBILITY OF AN IN-PERSON GROUP YOGA INTERVENTION.	2021	

20 1245  38 FEASIBILITY OF IMPLEMENTING A COMMUNITY-BASED RANDOMIZED TRIAL OF YOGA FOR WOMEN UNDERGOING CHEMOTHERAPY FOR BREAST CANCER. BACKGROUND: TREATMENT-RELATED SYMPTOMS AND DECREASED HEALTH-RELATED QUALITY OF LIFE (HRQOL) FREQUENTLY OCCUR DURING CHEMOTHERAPY FOR BREAST CANCER. ALTHOUGH RESEARCH FINDINGS SUGGEST THAT YOGA CAN REDUCE SYMPTOMS AND IMPROVE HRQOL AFTER TREATMENT, POTENTIAL BENEFITS OF YOGA DURING CHEMOTHERAPY HAVE RECEIVED MINIMAL ATTENTION. OBJECTIVE: TO ESTIMATE ACCRUAL, ADHERENCE, STUDY RETENTION, AND PRELIMINARY EFFICACY OF A YOGA INTERVENTION COMPARED WITH AN ACTIVE CONTROL GROUP FOR BREAST CANCER PATIENTS DURING CHEMOTHERAPY. METHODS: WOMEN WITH STAGE I-III BREAST CANCER WERE RECRUITED FROM 3 COMMUNITY CANCER CLINICS AND RANDOMIZED TO 10 WEEKS OF GENTLE YOGA OR WELLNESS EDUCATION. DEPRESSIVE SYMPTOMS, FATIGUE, SLEEP, AND HRQOL WERE ASSESSED AT BASELINE, MID-INTERVENTION (WEEK 5), AND AFTER INTERVENTION (WEEK 10). RESULTS: 40 WOMEN AGED 29-83 YEARS (MEDIAN, 48 YEARS; 88% WHITE) WERE RANDOMIZED TO YOGA (N = 22) OR WELLNESS EDUCATION (N = 18). THE GROUPS DID NOT DIFFER SIGNIFICANTLY ON BASELINE CHARACTERISTICS, ADHERENCE, OR STUDY RETENTION. PARTICIPANT FEEDBACK WAS POSITIVE AND COMPARABLE BETWEEN GROUPS. MEANINGFUL WITHIN-GROUP DIFFERENCES WERE IDENTIFIED FOR SLEEP ADEQUACY AND QUANTITY IN YOGA PARTICIPANTS AND FOR SOMNOLENCE IN WELLNESS-EDUCATION PARTICIPANTS. LIMITATIONS: SMALL SAMPLE SIZE AND LACK OF A USUAL-CARE CONTROL GROUP. CONCLUSIONS: THIS STUDY ESTABLISHED FEASIBILITY OF A COMMUNITY-BASED RANDOMIZED TRIAL OF YOGA AND AN ACTIVE COMPARISON GROUP FOR WOMEN UNDERGOING CHEMOTHERAPY FOR BREAST CANCER. PRELIMINARY EFFICACY ESTIMATES SUGGEST THAT YOGA IMPROVES SLEEP ADEQUACY SYMPTOM SEVERITY AND INTERFERENCE REMAINED STABLE DURING CHEMOTHERAPY FOR THE YOGA GROUP AND SNOWED A TREND TOWARD INCREASING IN THE CONTROL GROUP. THE STUDY HIGHLIGHTED OBSTACLES TO MULTISITE YOGA RESEARCH DURING CANCER TREATMENT. FUNDING/SPONSORSHIP: NATIONAL CANCER INSTITUTE (3U10 CA081851, PI; SHAW; R25 CA122061, PI: AVIS); TRANSLATIONAL SCIENCE INSTITUTE, WAKE FOREST SCHOOL OF MEDICINE.	2015