1 2497 216 YOGA AS PART OF A PACKAGE OF CARE VERSUS STANDARD CARE FOR SCHIZOPHRENIA. BACKGROUND: YOGA IS AN ANCIENT SPIRITUAL PRACTICE THAT ORIGINATED IN INDIA AND IS CURRENTLY ACCEPTED IN THE WESTERN WORLD AS A FORM OF RELAXATION AND EXERCISE. IT HAS BEEN OF INTEREST FOR PEOPLE WITH SCHIZOPHRENIA TO DETERMINE THE EFFICACY OF YOGA DELIVERED AS A PACKAGE OF CARE VERSUS STANDARD CARE. OBJECTIVES: TO EXAMINE THE EFFECTS OF YOGA AS A PACKAGE OF CARE VERSUS STANDARD CARE. SEARCH METHODS: WE SEARCHED THE COCHRANE SCHIZOPHRENIA GROUP TRIALS REGISTER (LATEST 30 MARCH 2017) WHICH IS BASED ON REGULAR SEARCHES OF MEDLINE, PUBMED, EMBASE, CINAHL, BIOSS, AMED, PSYCHINFO, AND REGISTRIES OF CLINICAL TRIALS. WE SEARCHED THE REFERENCES OF ALL INCLUDED STUDIES. THERE ARE NO LANGUAGE, DATE, DOCUMENT TYPE, OR PUBLICATION STATUS LIMITATIONS FOR INCLUSION OF RECORDS IN THE REGISTER. SELECTION CRITERIA: ALL RANDOMISED CONTROLLED TRIALS (RCTS) INCLUDING PEOPLE WITH SCHIZOPHRENIA COMPARING YOGA AS A PACKAGE OF CARE WITH STANDARD-CARE CONTROL. DATA COLLECTION AND ANALYSIS: THE REVIEW AUTHORS INDEPENDENTLY SELECTED STUDIES, QUALITY RATED THESE, AND EXTRACTED DATA. FOR BINARY OUTCOMES, WE CALCULATED RISK DIFFERENCE (RD) AND ITS 95% CONFIDENCE INTERVAL (CI), ON AN INTENTION-TO-TREAT (ITT) BASIS. FOR CONTINUOUS DATA, WE ESTIMATED THE MEAN DIFFERENCE (MD) BETWEEN GROUPS AND ITS CI. WE EMPLOYED MIXED-EFFECT AND FIXED-EFFECT MODELS FOR ANALYSIS. WE EXAMINED HETEROGENEITY (I(2) TECHNIQUE), ASSESSED RISK OF BIAS FOR INCLUDED STUDIES, AND CREATED A 'SUMMARY OF FINDINGS' TABLE USING GRADE (GRADING OF RECOMMENDATIONS ASSESSMENT, DEVELOPMENT AND EVALUATION). MAIN RESULTS: THREE STUDIES ARE INCLUDED IN THIS REVIEW. ALL OUTCOMES WERE SHORT TERM (LESS THAN EIGHT WEEKS). USEABLE DATA WERE REPORTED FOR TWO OUTCOMES ONLY; LEAVING THE STUDY EARLY AND QUALITY OF LIFE. NONE OF THE PARTICIPANTS LEFT THE STUDIES EARLY AND THERE WAS SOME EVIDENCE IN FAVOUR OF THE YOGA PACKAGE FOR QUALITY OF LIFE ENDPOINT SCORES (1 RCT, N=80, MD 22.93 CI 19.74 TO 26.12, LOW-QUALITY EVIDENCE). LEAVING THE STUDY EARLY DATA WERE EQUIVOCAL BETWEEN THE TREATMENT GROUPS (3 RCTS, N=193, RD 0.06 CI -0.01 TO 0.13, MEDIUM-QUALITY EVIDENCE, HIGH HETEROGENEITY). OVERALL, THIS REVIEW HAS AN INORDINATE NUMBER OF MISSING KEY OUTCOMES, WHICH INCLUDED MENTAL AND GLOBAL STATE, SOCIAL FUNCTIONING, PHYSICAL HEALTH, ADVERSE EFFECTS AND COSTS OF CARE. AUTHORS' CONCLUSIONS: A SMALL NUMBER OF SMALL STUDIES WERE INCLUDED IN THIS REVIEW AND THESE LACKED MANY KEY OUTCOMES. THE SPARSE DATA MEANS WE CANNOT STATE WITH ANY DEGREE OF CERTAINTY IF YOGA DELIVERED AS A PACKAGE OF CARE IS BENEFICIAL IN COMPARISON TO STANDARD CARE. 2017 2 2827 169 YOGA VERSUS NON-STANDARD CARE FOR SCHIZOPHRENIA. BACKGROUND: YOGA IS AN ANCIENT SPIRITUAL PRACTICE THAT ORIGINATED IN INDIA AND IS CURRENTLY ACCEPTED IN THE WESTERN WORLD AS A FORM OF RELAXATION AND EXERCISE. IT HAS BEEN OF INTEREST FOR PEOPLE WITH SCHIZOPHRENIA AS AN ALTERNATIVE OR ADJUNCTIVE TREATMENT. OBJECTIVES: TO SYSTEMATICALLY ASSESS THE EFFECTS OF YOGA VERSUS NON-STANDARD CARE FOR PEOPLE WITH SCHIZOPHRENIA. SEARCH METHODS: THE INFORMATION SPECIALIST OF THE COCHRANE SCHIZOPHRENIA GROUP SEARCHED THEIR SPECIALISED TRIALS REGISTER (LATEST 30 MARCH 2017), WHICH IS BASED ON REGULAR SEARCHES OF MEDLINE, PUBMED, EMBASE, CINAHL, BIOSIS, AMED, PSYCINFO, AND REGISTRIES OF CLINICAL TRIALS. WE SEARCHED THE REFERENCES OF ALL INCLUDED STUDIES. THERE ARE NO LANGUAGE, DATE, DOCUMENT TYPE, OR PUBLICATION STATUS LIMITATIONS FOR INCLUSION OF RECORDS IN THE REGISTER. SELECTION CRITERIA: ALL RANDOMISED CONTROLLED TRIALS (RCTS) INCLUDING PEOPLE WITH SCHIZOPHRENIA AND COMPARING YOGA WITH NON-STANDARD CARE. WE INCLUDED TRIALS THAT MET OUR SELECTION CRITERIA AND REPORTED USEABLE DATA. DATA COLLECTION AND ANALYSIS: THE REVIEW TEAM INDEPENDENTLY SELECTED STUDIES, ASSESSED QUALITY, AND EXTRACTED DATA. FOR BINARY OUTCOMES, WE CALCULATED RISK RATIO (RR) AND ITS 95% CONFIDENCE INTERVAL (CI), ON AN INTENTION-TO-TREAT BASIS. FOR CONTINUOUS DATA, WE ESTIMATED THE MEAN DIFFERENCE (MD) BETWEEN GROUPS AND ITS 95% CI. WE EMPLOYED A FIXED-EFFECT MODELS FOR ANALYSES. WE EXAMINED DATA FOR HETEROGENEITY (I(2) TECHNIQUE), ASSESSED RISK OF BIAS FOR INCLUDED STUDIES, AND CREATED A 'SUMMARY OF FINDINGS' TABLE FOR SEVEN MAIN OUTCOMES OF INTEREST USING GRADE (GRADING OF RECOMMENDATIONS ASSESSMENT, DEVELOPMENT AND EVALUATION). MAIN RESULTS: WE WERE ABLE TO INCLUDE SIX STUDIES (586 PARTICIPANTS). NON-STANDARD CARE CONSISTED SOLELY OF ANOTHER TYPE OF EXERCISE PROGRAMME. ALL OUTCOMES WERE SHORT TERM (LESS THAN SIX MONTHS). THERE WAS A CLEAR DIFFERENCE IN THE OUTCOME LEAVING THE STUDY EARLY (6 RCTS, N=586, RR 0.64 CI 0.49 TO 0.83, MEDIUM QUALITY EVIDENCE) IN FAVOUR OF THE YOGA GROUP. THERE WERE NO CLEAR DIFFERENCES BETWEEN GROUPS FOR THE REMAINING OUTCOMES. THESE INCLUDED MENTAL STATE (IMPROVEMENT IN POSITIVE AND NEGATIVE SYNDROME SCALE, 1 RCT, N=84, RR 0.81 CI 0.62 TO 1.07, LOW QUALITY EVIDENCE), SOCIAL FUNCTIONING (IMPROVEMENT IN SOCIAL OCCUPATIONAL FUNCTIONING SCALE, 1 RCT, N=84, RR 0.90 CI 0.78 TO 1.04, LOW QUALITY EVIDENCE), QUALITY OF LIFE (MENTAL HEALTH) (AVERAGE CHANGE 36-ITEM SHORT FORM SURVEY (SF-36) QUALITY-OF-LIFE SUB-SCALE, 1 RCT, N=69, MD -5.30 CI -17.78 TO 7.18, LOW QUALITY EVIDENCE), PHYSICAL HEALTH, (AVERAGE CHANGE WHOQOL-BREF PHYSICAL-HEALTH SUB-SCALE, 1 RCT, N=69, MD 9.22 CI -0.42 TO 18.86, LOW QUALITY EVIDENCE). ONLY ONE STUDY REPORTED ADVERSE EFFECTS, FINDING NO INCIDENCE OF ADVERSE EVENTS IN EITHER TREATMENT GROUP. THERE WERE A CONSIDERABLE NUMBER OF MISSING OUTCOMES, WHICH INCLUDED RELAPSE, CHANGE IN COGNITION, COSTS OF CARE, EFFECT ON STANDARD CARE, SERVICE INTERVENTION, DISABILITY, AND ACTIVITIES OF DAILY LIVING. AUTHORS' CONCLUSIONS: WE FOUND MINIMAL DIFFERENCES BETWEEN YOGA AND NON-STANDARD CARE, THE LATTER CONSISTING OF ANOTHER EXERCISE COMPARATOR, WHICH COULD BE BROADLY CONSIDERED AEROBIC EXERCISE. OUTCOMES WERE LARGELY BASED ON SINGLE STUDIES WITH LIMITED SAMPLE SIZES AND SHORT-TERM FOLLOW-UP. OVERALL, MANY OUTCOMES WERE NOT REPORTED AND EVIDENCE PRESENTED IN THIS REVIEW IS OF LOW TO MODERATE QUALITY - TOO WEAK TO INDICATE THAT YOGA IS SUPERIOR OR INFERIOR TO NON-STANDARD CARE CONTROL FOR MANAGEMENT OF PEOPLE WITH SCHIZOPHRENIA. 2017 3 2496 99 YOGA AS PART OF A PACKAGE OF CARE VERSUS NON-STANDARD CARE FOR SCHIZOPHRENIA. BACKGROUND: YOGA IS AN ANCIENT BODY-MIND PRACTICE WHICH ORIGINATED IN INDIA AND IS POPULAR IN THE WESTERN WORLD AS A FORM OF RELAXATION AND EXERCISE. IT HAS BEEN OF INTEREST FOR PEOPLE WITH SCHIZOPHRENIA TO DETERMINE THE EFFICACY OF YOGA DELIVERED AS A PACKAGE OF CARE VERSUS NON-STANDARD CARE. OBJECTIVES: TO EXAMINE THE EFFECTS OF YOGA AS PART OF A PACKAGE OF CARE VERSUS NON-STANDARD CARE FOR SCHIZOPHRENIA. SEARCH METHODS: WE SEARCHED THE COCHRANE SCHIZOPHRENIA GROUP TRIALS REGISTER (LATEST 15 MAY 2018) WHICH IS BASED ON REGULAR SEARCHES OF MEDLINE, PUBMED, EMBASE, CINAHL, BIOSS, AMED, PSYCHINFO, AND REGISTRIES OF CLINICAL TRIALS. WE SEARCHED THE REFERENCES OF ALL INCLUDED STUDIES. THERE ARE NO LANGUAGE, DATE, DOCUMENT TYPE, OR PUBLICATION STATUS LIMITATIONS FOR INCLUSION OF RECORDS IN THE REGISTER. SELECTION CRITERIA: ALL RANDOMISED CONTROLLED TRIALS (RCTS) INCLUDING PEOPLE WITH SCHIZOPHRENIA COMPARING YOGA AS PART OF A PACKAGE OF CARE WITH NON-STANDARD CARE. DATA COLLECTION AND ANALYSIS: THERE WERE NO DATA TO ANALYSE AS NO STUDIES MET THE INCLUSION CRITERIA. MAIN RESULTS: THE SEARCHES IDENTIFIED 30 STUDIES THAT COULD BE RELEVANT TO THIS REVIEW. AFTER CAREFUL INSPECTION, 29 WERE EXCLUDED AND ONE IS AWAITING CLASSIFICATION. NO DATA WERE AVAILABLE FOR ANALYSES. AUTHORS' CONCLUSIONS: IN VIEW OF THE LACK OF EVIDENCE FROM RCTS, IT IS CURRENTLY NOT POSSIBLE FOR US TO COMMENT ON THE USE OF YOGA AS PART OF A PACKAGE OF CARE VERSUS NON-STANDARD CARE. 2019 4 1189 44 EVIDENCE ON YOGA FOR HEALTH: A BIBLIOMETRIC ANALYSIS OF SYSTEMATIC REVIEWS. OBJECTIVE: TO SUPPORT THE RESEARCH AGENDA IN YOGA FOR HEALTH BY COMPREHENSIVELY IDENTIFYING SYSTEMATIC REVIEWS OF YOGA FOR HEALTH OUTCOMES AND CONDUCTING A BIBLIOMETRIC ANALYSIS TO DESCRIBE THEIR PUBLICATION CHARACTERISTICS AND TOPIC COVERAGE. METHODS: WE SEARCHED 7 DATABASES (MEDLINE/PUBMED, EMBASE, PSYCINFO, CINAHL, AMED, THE COCHRANE DATABASE OF SYSTEMATIC REVIEWS, AND PROSPERO) FROM THEIR INCEPTION TO NOVEMBER 2019 AND 1 DATABASE (INDMED) FROM INCEPTION TO JANUARY 2017. TWO AUTHORS INDEPENDENTLY SCREENED EACH RECORD FOR INCLUSION AND ONE AUTHOR EXTRACTED PUBLICATION CHARACTERISTICS AND TOPICS OF INCLUDED REVIEWS. RESULTS: WE RETRIEVED 2710 RECORDS AND INCLUDED 322 SYSTEMATIC REVIEWS. 157 REVIEWS WERE EXCLUSIVELY ON YOGA, AND 165 WERE ON YOGA AS ONE OF A LARGER CLASS OF INTERVENTIONS (E.G., EXERCISE). MOST REVIEWS WERE PUBLISHED IN 2012 OR LATER (260/322; 81 %). FIRST/CORRESPONDING AUTHORS WERE FROM 32 DIFFERENT COUNTRIES; THREE-QUARTERS WERE FROM THE USA, GERMANY, CHINA, AUSTRALIA, THE UK OR CANADA (240/322; 75 %). REVIEWS WERE MOST FREQUENTLY PUBLISHED IN SPECIALITY JOURNALS (161/322; 50 %) COMPLEMENTARY MEDICINE JOURNALS (66/322; 20 %) OR SYSTEMATIC REVIEW JOURNALS (59/322; 18 %). ALMOST ALL WERE PRESENT IN MEDLINE (296/322; 92 %). REVIEWS WERE MOST OFTEN FUNDED BY GOVERNMENT OR NON-PROFITS (134/322; 42 %), UNFUNDED (74/322; 23 %), OR NOT EXPLICIT ABOUT FUNDING (111/322; 34 %). COMMON HEALTH TOPICS WERE PSYCHIATRIC/COGNITIVE (N = 56), CANCER (N = 39) AND MUSCULOSKELETAL CONDITIONS (N = 36). MULTIPLE REVIEWS COVERED SIMILAR TOPICS, PARTICULARLY DEPRESSION/ANXIETY (N = 18), BREAST CANCER (N = 21), AND LOW BACK PAIN (N = 16). CONCLUSIONS: FURTHER RESEARCH SHOULD EXPLORE THE OVERALL QUALITY OF REPORTING AND CONDUCT OF SYSTEMATIC REVIEWS OF YOGA, THE DIRECTION AND CERTAINTY OF SPECIFIC CONCLUSIONS, AND DUPLICATION OR GAPS IN REVIEW COVERAGE OF TOPICS. 2021 5 2829 171 YOGA VERSUS STANDARD CARE FOR SCHIZOPHRENIA. BACKGROUND: YOGA IS AN ANCIENT SPIRITUAL PRACTICE THAT ORIGINATED IN INDIA AND IS CURRENTLY ACCEPTED IN THE WESTERN WORLD AS A FORM OF RELAXATION AND EXERCISE. IT HAS BEEN OF INTEREST FOR PEOPLE WITH SCHIZOPHRENIA TO DETERMINE ITS EFFICACY AS AN ADJUNCT TO STANDARD-CARE TREATMENT. OBJECTIVES: TO EXAMINE THE EFFECTS OF YOGA VERSUS STANDARD CARE FOR PEOPLE WITH SCHIZOPHRENIA. SEARCH METHODS: WE SEARCHED THE COCHRANE SCHIZOPHRENIA GROUP TRIALS REGISTER (NOVEMBER 2012 AND JANUARY 29, 2015), WHICH IS BASED ON REGULAR SEARCHES OF MEDLINE, PUBMED, EMBASE, CINAHL, BIOSIS, AMED, PSYCINFO, AND REGISTRIES OF CLINICAL TRIALS. WE SEARCHED THE REFERENCES OF ALL INCLUDED STUDIES. THERE WERE NO LANGUAGE, DATE, DOCUMENT TYPE, OR PUBLICATION STATUS LIMITATIONS FOR INCLUSION OF RECORDS IN THE REGISTER. SELECTION CRITERIA: ALL RANDOMISED CONTROLLED TRIALS (RCTS) INCLUDING PEOPLE WITH SCHIZOPHRENIA COMPARING YOGA TO STANDARD-CARE CONTROL. DATA COLLECTION AND ANALYSIS: THE REVIEW TEAM INDEPENDENTLY SELECTED STUDIES, QUALITY RATED THESE, AND EXTRACTED DATA. FOR BINARY OUTCOMES, WE CALCULATED RISK RATIO (RR) AND ITS 95% CONFIDENCE INTERVAL (CI), ON AN INTENTION-TO-TREAT BASIS. FOR CONTINUOUS DATA, WE ESTIMATED THE MEAN DIFFERENCE (MD) BETWEEN GROUPS AND ITS 95% CI. WE EMPLOYED MIXED-EFFECT AND FIXED-EFFECT MODELS FOR ANALYSES. WE EXAMINED DATA FOR HETEROGENEITY (I(2) TECHNIQUE), ASSESSED RISK OF BIAS FOR INCLUDED STUDIES, AND CREATED 'SUMMARY OF FINDINGS' TABLES USING GRADE (GRADING OF RECOMMENDATIONS ASSESSMENT, DEVELOPMENT AND EVALUATION). MAIN RESULTS: WE INCLUDED EIGHT STUDIES IN THE REVIEW. ALL OUTCOMES WERE SHORT TERM (LESS THAN SIX MONTHS). THERE WERE CLEAR DIFFERENCES IN A NUMBER OF OUTCOMES IN FAVOUR OF THE YOGA GROUP, ALTHOUGH THESE WERE BASED ON ONE STUDY EACH, WITH THE EXCEPTION OF LEAVING THE STUDY EARLY. THESE INCLUDED MENTAL STATE (IMPROVEMENT IN POSITIVE AND NEGATIVE SYNDROME SCALE, 1 RCT, N = 83, RR 0.70 CI 0.55 TO 0.88, MEDIUM-QUALITY EVIDENCE), SOCIAL FUNCTIONING (IMPROVEMENT IN SOCIAL OCCUPATIONAL FUNCTIONING SCALE, 1 RCT, N = 83, RR 0.88 CI 0.77 TO 1, MEDIUM-QUALITY EVIDENCE), QUALITY OF LIFE (AVERAGE CHANGE 36-ITEM SHORT FORM SURVEY (SF-36) QUALITY-OF-LIFE SUBSCALE, 1 RCT, N = 60, MD 15.50, 95% CI 4.27 TO 26.73, LOW-QUALITY EVIDENCE), AND LEAVING THE STUDY EARLY (8 RCTS, N = 457, RR 0.91 CI 0.6 TO 1.37, MEDIUM-QUALITY EVIDENCE). FOR THE OUTCOME OF PHYSICAL HEALTH, THERE WAS NOT A CLEAR DIFFERENCE BETWEEN GROUPS (AVERAGE CHANGE SF-36 PHYSICAL-HEALTH SUBSCALE, 1 RCT, N = 60, MD 6.60, 95% CI -2.44 TO 15.64, LOW-QUALITY EVIDENCE). ONLY ONE STUDY REPORTED ADVERSE EFFECTS, FINDING NO INCIDENCE OF ADVERSE EVENTS IN EITHER TREATMENT GROUP. THIS REVIEW WAS SUBJECT TO A CONSIDERABLE NUMBER OF MISSING OUTCOMES, WHICH INCLUDED GLOBAL STATE, CHANGE IN COGNITION, COSTS OF CARE, EFFECT ON STANDARD CARE, SERVICE INTERVENTION, DISABILITY, AND ACTIVITIES OF DAILY LIVING. AUTHORS' CONCLUSIONS: EVEN THOUGH WE FOUND SOME POSITIVE EVIDENCE IN FAVOUR OF YOGA OVER STANDARD-CARE CONTROL, THIS SHOULD BE INTERPRETED CAUTIOUSLY IN VIEW OF OUTCOMES LARGELY BASED EACH ON ONE STUDY WITH LIMITED SAMPLE SIZES AND SHORT-TERM FOLLOW-UP. OVERALL, MANY OUTCOMES WERE NOT REPORTED AND EVIDENCE PRESENTED IN THIS REVIEW IS OF LOW TO MODERATE QUALITY - -TOO WEAK TO INDICATE THAT YOGA IS SUPERIOR TO STANDARD-CARE CONTROL FOR THE MANAGEMENT OF SCHIZOPHRENIA. 2015 6 355 46 ASSOCIATED FACTORS AND CONSEQUENCES OF RISK OF BIAS IN RANDOMIZED CONTROLLED TRIALS OF YOGA: A SYSTEMATIC REVIEW. BACKGROUND: BIAS IN RANDOMIZED CONTROLLED TRIALS (RCTS) OF COMPLEMENTARY THERAPY INTERVENTIONS SEEMS TO BE ASSOCIATED WITH SPECIFIC FACTORS AND TO POTENTIALLY DISTORT THE STUDIES' CONCLUSIONS. THIS SYSTEMATIC REVIEW ASSESSED ASSOCIATED FACTORS OF RISK OF BIAS AND CONSEQUENCES FOR THE STUDIES' CONCLUSIONS IN RCTS OF YOGA AS ONE OF THE MOST COMMONLY USED COMPLEMENTARY THERAPIES. METHODS: MEDLINE/PUBMED, SCOPUS, INDMED AND THE COCHRANE LIBRARY WERE SEARCHED THROUGH FEBRUARY 2014 FOR YOGA RCTS. RISK OF SELECTION BIAS WAS ASSESSED USING THE COCHRANE TOOL AND REGRESSED TO A) PUBLICATION YEAR; B) COUNTRY OF ORIGIN; C) JOURNAL TYPE; AND D) IMPACT FACTOR USING MULTIPLE LOGISTIC REGRESSION ANALYSIS. LIKEWISE, THE AUTHORS' CONCLUSIONS WERE REGRESSED TO RISK OF BIAS. RESULTS: A TOTAL OF 312 RCTS WERE INCLUDED. IMPACT FACTOR RANGED FROM 0.0 TO 39.2 (MEDIAN = 1.3); 60 RCT (19.2%) HAD A LOW RISK OF SELECTION BIAS, AND 252 (80.8%) HAD A HIGH OR UNCLEAR RISK OF SELECTION BIAS. ONLY PUBLICATION YEAR AND IMPACT FACTOR SIGNIFICANTLY PREDICTED LOW RISK OF BIAS; RCTS PUBLISHED AFTER 2001 (ADJUSTED ODDS RATIO (OR) = 12.6; 95% CONFIDENCE INTERVAL (CI) = 1.7, 94.0; P<0.001) AND THOSE PUBLISHED IN JOURNALS WITH IMPACT FACTOR (ADJUSTED OR = 2.6; 95%CI = 1.4, 4.9; P = 0.004) WERE MORE LIKELY TO HAVE LOW RISK OF BIAS. THE AUTHORS' CONCLUSIONS WERE NOT ASSOCIATED WITH RISK OF BIAS. CONCLUSIONS: RISK OF SELECTION BIAS WAS GENERALLY HIGH IN RCTS OF YOGA; ALTHOUGH THE SITUATION HAS IMPROVED SINCE THE PUBLICATION OF THE REVISED CONSORT STATEMENT 2001. PRE-CONSORT RCTS AND THOSE PUBLISHED IN JOURNALS WITHOUT IMPACT FACTOR SHOULD BE HANDLED WITH INCREASED CARE; ALTHOUGH RISK OF BIAS IS UNLIKELY TO DISTORT THE RCTS' CONCLUSIONS. 2015 7 2616 73 YOGA FOR SECONDARY PREVENTION OF CORONARY HEART DISEASE. BACKGROUND: CORONARY HEART DISEASE (CHD) IS THE MAJOR CAUSE OF EARLY MORBIDITY AND MORTALITY IN MOST DEVELOPED COUNTRIES. SECONDARY PREVENTION AIMS TO PREVENT REPEAT CARDIAC EVENTS AND DEATH IN PEOPLE WITH ESTABLISHED CHD. LIFESTYLE MODIFICATIONS PLAY AN IMPORTANT ROLE IN SECONDARY PREVENTION. YOGA HAS BEEN REGARDED AS A TYPE OF PHYSICAL ACTIVITY AS WELL AS A STRESS MANAGEMENT STRATEGY. GROWING EVIDENCE SUGGESTS THE BENEFICIAL EFFECTS OF YOGA ON VARIOUS AILMENTS. OBJECTIVES: TO DETERMINE THE EFFECTIVENESS OF YOGA FOR THE SECONDARY PREVENTION OF MORTALITY AND MORBIDITY IN, AND ON THE HEALTH-RELATED QUALITY OF LIFE OF, INDIVIDUALS WITH CHD. SEARCH METHODS: THIS IS AN UPDATE OF A REVIEW PREVIOUSLY PUBLISHED IN 2012. FOR THIS UPDATED REVIEW, WE SEARCHED THE COCHRANE CENTRAL REGISTER OF CONTROLLED TRIALS (CENTRAL) IN THE COCHRANE LIBRARY (ISSUE 1 OF 12, 2014), MEDLINE (1948 TO FEBRUARY WEEK 1 2014), EMBASE (1980 TO 2014 WEEK 6), WEB OF SCIENCE (THOMSON REUTERS, 1970 TO 12 FEBRUARY 2014), CHINA JOURNAL NET (1994 TO MAY 2014), WANFANG DATA (1990 TO MAY 2014), AND INDEX TO CHINESE PERIODICALS OF HONG KONG (HKINCHIP) (FROM 1980). ONGOING STUDIES WERE IDENTIFIED IN THE METAREGISTER OF CONTROLLED TRIALS (MAY 2014) AND THE WORLD HEALTH ORGANIZATION INTERNATIONAL CLINICAL TRIALS REGISTRY PLATFORM (MAY 2014). WE APPLIED NO LANGUAGE RESTRICTIONS. SELECTION CRITERIA: WE PLANNED TO INCLUDE RANDOMISED CONTROLLED TRIALS (RCTS) INVESTIGATING THE INFLUENCE OF YOGA PRACTICE ON CHD OUTCOMES IN MEN AND WOMEN (AGED 18 YEARS AND OVER) WITH A DIAGNOSIS OF ACUTE OR CHRONIC CHD. STUDIES WERE ELIGIBLE FOR INCLUSION IF THEY HAD A FOLLOW-UP DURATION OF SIX MONTHS OR MORE. WE CONSIDERED STUDIES THAT COMPARED ONE GROUP PRACTICING A TYPE OF YOGA WITH A CONTROL GROUP RECEIVING EITHER NO INTERVENTION OR INTERVENTIONS OTHER THAN YOGA. DATA COLLECTION AND ANALYSIS: TWO AUTHORS INDEPENDENTLY SELECTED STUDIES ACCORDING TO PRESPECIFIED INCLUSION CRITERIA. WE RESOLVED DISAGREEMENTS EITHER BY CONSENSUS OR BY DISCUSSION WITH A THIRD AUTHOR. MAIN RESULTS: WE FOUND NO ELIGIBLE RCTS THAT MET THE INCLUSION CRITERIA OF THE REVIEW AND THUS WE WERE UNABLE TO PERFORM A META-ANALYSIS. AUTHORS' CONCLUSIONS: THE EFFECTIVENESS OF YOGA FOR SECONDARY PREVENTION IN CHD REMAINS UNCERTAIN. LARGE RCTS OF HIGH QUALITY ARE NEEDED. 2015 8 2587 102 YOGA FOR IMPROVING HEALTH-RELATED QUALITY OF LIFE, MENTAL HEALTH AND CANCER-RELATED SYMPTOMS IN WOMEN DIAGNOSED WITH BREAST CANCER. BACKGROUND: BREAST CANCER IS THE CANCER MOST FREQUENTLY DIAGNOSED IN WOMEN WORLDWIDE. EVEN THOUGH SURVIVAL RATES ARE CONTINUALLY INCREASING, BREAST CANCER IS OFTEN ASSOCIATED WITH LONG-TERM PSYCHOLOGICAL DISTRESS, CHRONIC PAIN, FATIGUE AND IMPAIRED QUALITY OF LIFE. YOGA COMPRISES ADVICE FOR AN ETHICAL LIFESTYLE, SPIRITUAL PRACTICE, PHYSICAL ACTIVITY, BREATHING EXERCISES AND MEDITATION. IT IS A COMPLEMENTARY THERAPY THAT IS COMMONLY RECOMMENDED FOR BREAST CANCER-RELATED IMPAIRMENTS AND HAS BEEN SHOWN TO IMPROVE PHYSICAL AND MENTAL HEALTH IN PEOPLE WITH DIFFERENT CANCER TYPES. OBJECTIVES: TO ASSESS EFFECTS OF YOGA ON HEALTH-RELATED QUALITY OF LIFE, MENTAL HEALTH AND CANCER-RELATED SYMPTOMS AMONG WOMEN WITH A DIAGNOSIS OF BREAST CANCER WHO ARE RECEIVING ACTIVE TREATMENT OR HAVE COMPLETED TREATMENT. SEARCH METHODS: WE SEARCHED THE COCHRANE BREAST CANCER SPECIALISED REGISTER, MEDLINE (VIA PUBMED), EMBASE, THE COCHRANE CENTRAL REGISTER OF CONTROLLED TRIALS (CENTRAL; 2016, ISSUE 1), INDEXING OF INDIAN MEDICAL JOURNALS (INDMED), THE WORLD HEALTH ORGANIZATION (WHO) INTERNATIONAL CLINICAL TRIALS REGISTRY PLATFORM (ICTRP) SEARCH PORTAL AND CLINICALTRIALS.GOV ON 29 JANUARY 2016. WE ALSO SEARCHED REFERENCE LISTS OF IDENTIFIED RELEVANT TRIALS OR REVIEWS, AS WELL AS CONFERENCE PROCEEDINGS OF THE INTERNATIONAL CONGRESS ON COMPLEMENTARY MEDICINE RESEARCH (ICCMR), THE EUROPEAN CONGRESS FOR INTEGRATIVE MEDICINE (ECIM) AND THE AMERICAN SOCIETY OF CLINICAL ONCOLOGY (ASCO). WE APPLIED NO LANGUAGE RESTRICTIONS. SELECTION CRITERIA: RANDOMISED CONTROLLED TRIALS WERE ELIGIBLE WHEN THEY (1) COMPARED YOGA INTERVENTIONS VERSUS NO THERAPY OR VERSUS ANY OTHER ACTIVE THERAPY IN WOMEN WITH A DIAGNOSIS OF NON-METASTATIC OR METASTATIC BREAST CANCER, AND (2) ASSESSED AT LEAST ONE OF THE PRIMARY OUTCOMES ON PATIENT-REPORTED INSTRUMENTS, INCLUDING HEALTH-RELATED QUALITY OF LIFE, DEPRESSION, ANXIETY, FATIGUE OR SLEEP DISTURBANCES. DATA COLLECTION AND ANALYSIS: TWO REVIEW AUTHORS INDEPENDENTLY COLLECTED DATA ON METHODS AND RESULTS. WE EXPRESSED OUTCOMES AS STANDARDISED MEAN DIFFERENCES (SMDS) WITH 95% CONFIDENCE INTERVALS (CIS) AND CONDUCTED RANDOM-EFFECTS MODEL META-ANALYSES. WE ASSESSED POTENTIAL RISK OF PUBLICATION BIAS THROUGH VISUAL ANALYSIS OF FUNNEL PLOT SYMMETRY AND HETEROGENEITY BETWEEN STUDIES BY USING THE CHI(2) TEST AND THE I(2) STATISTIC. WE CONDUCTED SUBGROUP ANALYSES FOR CURRENT TREATMENT STATUS, TIME SINCE DIAGNOSIS, STAGE OF CANCER AND TYPE OF YOGA INTERVENTION. MAIN RESULTS: WE INCLUDED 24 STUDIES WITH A TOTAL OF 2166 PARTICIPANTS, 23 OF WHICH PROVIDED DATA FOR META-ANALYSIS. THIRTEEN STUDIES HAD LOW RISK OF SELECTION BIAS, FIVE STUDIES REPORTED ADEQUATE BLINDING OF OUTCOME ASSESSMENT AND 15 STUDIES HAD LOW RISK OF ATTRITION BIAS.SEVENTEEN STUDIES THAT COMPARED YOGA VERSUS NO THERAPY PROVIDED MODERATE-QUALITY EVIDENCE SHOWING THAT YOGA IMPROVED HEALTH-RELATED QUALITY OF LIFE (POOLED SMD 0.22, 95% CI 0.04 TO 0.40; 10 STUDIES, 675 PARTICIPANTS), REDUCED FATIGUE (POOLED SMD -0.48, 95% CI -0.75 TO -0.20; 11 STUDIES, 883 PARTICIPANTS) AND REDUCED SLEEP DISTURBANCES IN THE SHORT TERM (POOLED SMD -0.25, 95% CI -0.40 TO -0.09; SIX STUDIES, 657 PARTICIPANTS). THE FUNNEL PLOT FOR HEALTH-RELATED QUALITY OF LIFE WAS ASYMMETRICAL, FAVOURING NO THERAPY, AND THE FUNNEL PLOT FOR FATIGUE WAS ROUGHLY SYMMETRICAL. THIS HINTS AT OVERALL LOW RISK OF PUBLICATION BIAS. YOGA DID NOT APPEAR TO REDUCE DEPRESSION (POOLED SMD -0.13, 95% CI -0.31 TO 0.05; SEVEN STUDIES, 496 PARTICIPANTS; LOW-QUALITY EVIDENCE) OR ANXIETY (POOLED SMD -0.53, 95% CI -1.10 TO 0.04; SIX STUDIES, 346 PARTICIPANTS; VERY LOW-QUALITY EVIDENCE) IN THE SHORT TERM AND HAD NO MEDIUM-TERM EFFECTS ON HEALTH-RELATED QUALITY OF LIFE (POOLED SMD 0.10, 95% CI -0.23 TO 0.42; TWO STUDIES, 146 PARTICIPANTS; LOW-QUALITY EVIDENCE) OR FATIGUE (POOLED SMD -0.04, 95% CI -0.36 TO 0.29; TWO STUDIES, 146 PARTICIPANTS; LOW-QUALITY EVIDENCE). INVESTIGATORS REPORTED NO SERIOUS ADVERSE EVENTS.FOUR STUDIES THAT COMPARED YOGA VERSUS PSYCHOSOCIAL/EDUCATIONAL INTERVENTIONS PROVIDED MODERATE-QUALITY EVIDENCE INDICATING THAT YOGA CAN REDUCE DEPRESSION (POOLED SMD -2.29, 95% CI -3.97 TO -0.61; FOUR STUDIES, 226 PARTICIPANTS), ANXIETY (POOLED SMD -2.21, 95% CI -3.90 TO -0.52; THREE STUDIES, 195 PARTICIPANTS) AND FATIGUE (POOLED SMD -0.90, 95% CI -1.31 TO -0.50; TWO STUDIES, 106 PARTICIPANTS) IN THE SHORT TERM. VERY LOW-QUALITY EVIDENCE SHOWED NO SHORT-TERM EFFECTS ON HEALTH-RELATED QUALITY OF LIFE (POOLED SMD 0.81, 95% CI -0.50 TO 2.12; TWO STUDIES, 153 PARTICIPANTS) OR SLEEP DISTURBANCES (POOLED SMD -0.21, 95% CI -0.76 TO 0.34; TWO STUDIES, 119 PARTICIPANTS). NO TRIAL ADEQUATELY REPORTED SAFETY-RELATED DATA.THREE STUDIES THAT COMPARED YOGA VERSUS EXERCISE PRESENTED VERY LOW-QUALITY EVIDENCE SHOWING NO SHORT-TERM EFFECTS ON HEALTH-RELATED QUALITY OF LIFE (POOLED SMD -0.04, 95% CI -0.30 TO 0.23; THREE STUDIES, 233 PARTICIPANTS) OR FATIGUE (POOLED SMD -0.21, 95% CI -0.66 TO 0.25; THREE STUDIES, 233 PARTICIPANTS); NO TRIAL PROVIDED SAFETY-RELATED DATA. AUTHORS' CONCLUSIONS: MODERATE-QUALITY EVIDENCE SUPPORTS THE RECOMMENDATION OF YOGA AS A SUPPORTIVE INTERVENTION FOR IMPROVING HEALTH-RELATED QUALITY OF LIFE AND REDUCING FATIGUE AND SLEEP DISTURBANCES WHEN COMPARED WITH NO THERAPY, AS WELL AS FOR REDUCING DEPRESSION, ANXIETY AND FATIGUE, WHEN COMPARED WITH PSYCHOSOCIAL/EDUCATIONAL INTERVENTIONS. VERY LOW-QUALITY EVIDENCE SUGGESTS THAT YOGA MIGHT BE AS EFFECTIVE AS OTHER EXERCISE INTERVENTIONS AND MIGHT BE USED AS AN ALTERNATIVE TO OTHER EXERCISE PROGRAMMES. 2017 9 548 39 CONTENT, STRUCTURE, AND DELIVERY CHARACTERISTICS OF YOGA INTERVENTIONS FOR MANAGING HYPERTENSION: A SYSTEMATIC REVIEW PROTOCOL. AIMS: THIS SYSTEMATIC REVIEW AIMS TO SUMMARIZE THE CONTENT, STRUCTURE, AND DELIVERY CHARACTERISTICS OF YOGA INTERVENTIONS USED FOR MANAGING HYPERTENSION. INTRODUCTION: GLOBALLY, HYPERTENSION-RELATED MORBIDITY AND MORTALITY ARE HIGH. YOGA MIGHT BE A POTENTIAL SOLUTION FOR MANAGING HYPERTENSION. SEVERAL SYSTEMATIC REVIEWS HAVE EVALUATED THE EFFECTIVENESS OF YOGA INTERVENTIONS FOR MANAGING HYPERTENSION. THERE IS A NEED TO SUMMARIZE THE CONTENT, STRUCTURE, AND DELIVERY CHARACTERISTICS OF YOGA INTERVENTIONS USED FOR MANAGING HYPERTENSION. INCLUSION CRITERIA: RANDOMIZED CONTROLLED TRIALS ASSESSING THE EFFECTIVENESS OF YOGA INTERVENTIONS FOR MANAGING HYPERTENSION IN ADULTS AND REPORTING EITHER THE CONTENT, STRUCTURE, OR DELIVERY CHARACTERISTICS WILL BE INCLUDED IN THIS SYSTEMATIC REVIEW. METHODS: THE JOANNA BRIGGS INSTITUTE SYSTEMATIC REVIEW METHODOLOGY WILL BE FOLLOWED TO CONDUCT THE REVIEW. WE AIM TO SEARCH FOR A WIDE RANGE OF SOURCES TO FIND BOTH PUBLISHED AND UNPUBLISHED STUDIES. THE FOLLOWING DATABASES WILL BE SEARCHED: MEDLINE, EMBASE, CINAHL, PSYCINFO, ALLIED AND COMPLEMENTARY MEDICINE (AMED), WEB OF SCIENCE, COCHRANE CENTRAL REGISTER OF CONTROLLED TRIALS (CENTRAL), TURNING RESEARCH INTO PRACTICE (TRIP), AYUSH RESEARCH PORTAL, A BIBLIOGRAPHY OF INDIAN MEDICINE (ABIM), DIGITAL HELPLINE FOR AYURVEDA RESEARCH ARTICLES (DHARA), CAM-QUEST, AND DIRECTORY OF OPEN ACCESS JOURNALS (DOAJ). THE SEARCH FOR UNPUBLISHED STUDIES WILL INCLUDE OPENGREY, ETHOS, AND PROQUEST DISSERTATIONS AND THESES. DATABASES WILL BE SEARCHED FROM THEIR INCEPTION DATES, AND NO LANGUAGE RESTRICTIONS WILL BE APPLIED. A NARRATIVE DESCRIPTION OF THE FINDINGS WILL BE WRITTEN, STRUCTURED AROUND THE AIMS OF THIS SYSTEMATIC REVIEW. SYSTEMATIC REVIEW REGISTRATION NUMBER: CRD42019139404. 2020 10 2629 99 YOGA FOR THE PRIMARY PREVENTION OF CARDIOVASCULAR DISEASE. BACKGROUND: A SEDENTARY LIFESTYLE AND STRESS ARE MAJOR RISK FACTORS FOR CARDIOVASCULAR DISEASE (CVD). SINCE YOGA INVOLVES EXERCISE AND IS THOUGHT TO HELP IN STRESS REDUCTION IT MAY BE AN EFFECTIVE STRATEGY IN THE PRIMARY PREVENTION OF CVD. OBJECTIVES: TO DETERMINE THE EFFECT OF ANY TYPE OF YOGA ON THE PRIMARY PREVENTION OF CVD. SEARCH METHODS: WE SEARCHED THE FOLLOWING ELECTRONIC DATABASES: THE COCHRANE CENTRAL REGISTER OF CONTROLLED TRIALS (CENTRAL) (2013, ISSUE 11) IN THE COCHRANE LIBRARY; MEDLINE (OVID) (1946 TO NOVEMBER WEEK 3 2013); EMBASE CLASSIC + EMBASE (OVID) (1947 TO 2013 WEEK 48); WEB OF SCIENCE (THOMSON REUTERS) (1970 TO 4 DECEMBER 2013); DATABASE OF ABSTRACTS OF REVIEWS OF EFFECTS (DARE), HEALTH TECHNOLOGY ASSESSMENT DATABASE AND HEALTH ECONOMICS EVALUATIONS DATABASE (ISSUE 4 OF 4, 2013) IN THE COCHRANE LIBRARY. WE ALSO SEARCHED A NUMBER OF ASIAN DATABASES AND THE ALLIED AND COMPLEMENTARY MEDICINE DATABASE (AMED) (INCEPTION TO DECEMBER 2012). WE SEARCHED TRIAL REGISTERS AND REFERENCE LISTS OF REVIEWS AND ARTICLES, AND APPROACHED EXPERTS IN THE FIELD. WE APPLIED NO LANGUAGE RESTRICTIONS. SELECTION CRITERIA: RANDOMISED CONTROLLED TRIALS LASTING AT LEAST THREE MONTHS INVOLVING HEALTHY ADULTS OR THOSE AT HIGH RISK OF CVD. TRIALS EXAMINED ANY TYPE OF YOGA AND THE COMPARISON GROUP WAS NO INTERVENTION OR MINIMAL INTERVENTION. OUTCOMES OF INTEREST WERE CLINICAL CVD EVENTS AND MAJOR CVD RISK FACTORS. WE DID NOT INCLUDE ANY TRIALS THAT INVOLVED MULTIFACTORIAL LIFESTYLE INTERVENTIONS OR WEIGHT LOSS. DATA COLLECTION AND ANALYSIS: TWO AUTHORS INDEPENDENTLY SELECTED TRIALS FOR INCLUSION, EXTRACTED DATA AND ASSESSED THE RISK OF BIAS. MAIN RESULTS: WE IDENTIFIED 11 TRIALS (800 PARTICIPANTS) AND TWO ONGOING STUDIES. STYLE AND DURATION OF YOGA DIFFERED BETWEEN TRIALS. HALF OF THE PARTICIPANTS RECRUITED TO THE STUDIES WERE AT HIGH RISK OF CVD. MOST OF STUDIES WERE AT RISK OF PERFORMANCE BIAS, WITH INADEQUATE DETAILS REPORTED IN MANY OF THEM TO JUDGE THE RISK OF SELECTION BIAS.NO STUDY REPORTED CARDIOVASCULAR MORTALITY, ALL-CAUSE MORTALITY OR NON-FATAL EVENTS, AND MOST STUDIES WERE SMALL AND SHORT-TERM. THERE WAS SUBSTANTIAL HETEROGENEITY BETWEEN STUDIES MAKING IT IMPOSSIBLE TO COMBINE STUDIES STATISTICALLY FOR SYSTOLIC BLOOD PRESSURE AND TOTAL CHOLESTEROL. YOGA WAS FOUND TO PRODUCE REDUCTIONS IN DIASTOLIC BLOOD PRESSURE (MEAN DIFFERENCE (MD) -2.90 MMHG, 95% CONFIDENCE INTERVAL (CI) -4.52 TO -1.28), WHICH WAS STABLE ON SENSITIVITY ANALYSIS, TRIGLYCERIDES (MD -0.27 MMOL/L, 95% CI -0.44 TO -0.11) AND HIGH-DENSITY LIPOPROTEIN (HDL) CHOLESTEROL (MD 0.08 MMOL/L, 95% CI 0.02 TO 0.14). HOWEVER, THE CONTRIBUTING STUDIES WERE SMALL, SHORT-TERM AND AT UNCLEAR OR HIGH RISK OF BIAS. THERE WAS NO CLEAR EVIDENCE OF A DIFFERENCE BETWEEN GROUPS FOR LOW-DENSITY LIPOPROTEIN (LDL) CHOLESTEROL (MD -0.09 MMOL/L, 95% CI -0.48 TO 0.30), ALTHOUGH THERE WAS MODERATE STATISTICAL HETEROGENEITY. ADVERSE EVENTS, OCCURRENCE OF TYPE 2 DIABETES AND COSTS WERE NOT REPORTED IN ANY OF THE INCLUDED STUDIES. QUALITY OF LIFE WAS MEASURED IN THREE TRIALS BUT THE RESULTS WERE INCONCLUSIVE. AUTHORS' CONCLUSIONS: THE LIMITED EVIDENCE COMES FROM SMALL, SHORT-TERM, LOW-QUALITY STUDIES. THERE IS SOME EVIDENCE THAT YOGA HAS FAVOURABLE EFFECTS ON DIASTOLIC BLOOD PRESSURE, HDL CHOLESTEROL AND TRIGLYCERIDES, AND UNCERTAIN EFFECTS ON LDL CHOLESTEROL. THESE RESULTS SHOULD BE CONSIDERED AS EXPLORATORY AND INTERPRETED WITH CAUTION. 2014 11 2543 106 YOGA FOR ASTHMA. BACKGROUND: ASTHMA IS A COMMON CHRONIC INFLAMMATORY DISORDER AFFECTING ABOUT 300 MILLION PEOPLE WORLDWIDE. AS A HOLISTIC THERAPY, YOGA HAS THE POTENTIAL TO RELIEVE BOTH THE PHYSICAL AND PSYCHOLOGICAL SUFFERING OF PEOPLE WITH ASTHMA, AND ITS POPULARITY HAS EXPANDED GLOBALLY. A NUMBER OF CLINICAL TRIALS HAVE BEEN CARRIED OUT TO EVALUATE THE EFFECTS OF YOGA PRACTICE, WITH INCONSISTENT RESULTS. OBJECTIVES: TO ASSESS THE EFFECTS OF YOGA IN PEOPLE WITH ASTHMA. SEARCH METHODS: WE SYSTEMATICALLY SEARCHED THE COCHRANE AIRWAYS GROUP REGISTER OF TRIALS, WHICH IS DERIVED FROM SYSTEMATIC SEARCHES OF BIBLIOGRAPHIC DATABASES INCLUDING THE COCHRANE CENTRAL REGISTER OF CONTROLLED TRIALS (CENTRAL), MEDLINE, EMBASE, CINAHL, AMED, AND PSYCINFO, AND HANDSEARCHING OF RESPIRATORY JOURNALS AND MEETING ABSTRACTS. WE ALSO SEARCHED PEDRO. WE SEARCHED CLINICALTRIALS.GOV AND THE WHO ICTRP SEARCH PORTAL. WE SEARCHED ALL DATABASES FROM THEIR INCEPTION TO 22 JULY 2015, AND USED NO RESTRICTION ON LANGUAGE OF PUBLICATION. WE CHECKED THE REFERENCE LISTS OF ELIGIBLE STUDIES AND RELEVANT REVIEW ARTICLES FOR ADDITIONAL STUDIES. WE ATTEMPTED TO CONTACT INVESTIGATORS OF ELIGIBLE STUDIES AND EXPERTS IN THE FIELD TO LEARN OF OTHER PUBLISHED AND UNPUBLISHED STUDIES. SELECTION CRITERIA: WE INCLUDED RANDOMISED CONTROLLED TRIALS (RCTS) THAT COMPARED YOGA WITH USUAL CARE (OR NO INTERVENTION) OR SHAM INTERVENTION IN PEOPLE WITH ASTHMA AND REPORTED AT LEAST ONE OF THE FOLLOWING OUTCOMES: QUALITY OF LIFE, ASTHMA SYMPTOM SCORE, ASTHMA CONTROL, LUNG FUNCTION MEASURES, ASTHMA MEDICATION USAGE, AND ADVERSE EVENTS. DATA COLLECTION AND ANALYSIS: WE EXTRACTED BIBLIOGRAPHIC INFORMATION, CHARACTERISTICS OF PARTICIPANTS, CHARACTERISTICS OF INTERVENTIONS AND CONTROLS, CHARACTERISTICS OF METHODOLOGY, AND RESULTS FOR THE OUTCOMES OF OUR INTEREST FROM ELIGIBLE STUDIES. FOR CONTINUOUS OUTCOMES, WE USED MEAN DIFFERENCE (MD) WITH 95% CONFIDENCE INTERVAL (CI) TO DENOTE THE TREATMENT EFFECTS, IF THE OUTCOMES WERE MEASURED BY THE SAME SCALE ACROSS STUDIES. ALTERNATIVELY, IF THE OUTCOMES WERE MEASURED BY DIFFERENT SCALES ACROSS STUDIES, WE USED STANDARDISED MEAN DIFFERENCE (SMD) WITH 95% CI. FOR DICHOTOMOUS OUTCOMES, WE USED RISK RATIO (RR) WITH 95% CI TO MEASURE THE TREATMENT EFFECTS. WE PERFORMED META-ANALYSIS WITH REVIEW MANAGER 5.3. WE USED THE FIXED-EFFECT MODEL TO POOL THE DATA, UNLESS THERE WAS SUBSTANTIAL HETEROGENEITY AMONG STUDIES, IN WHICH CASE WE USED THE RANDOM-EFFECTS MODEL INSTEAD. FOR OUTCOMES INAPPROPRIATE OR IMPOSSIBLE TO POOL QUANTITATIVELY, WE CONDUCTED A DESCRIPTIVE ANALYSIS AND SUMMARISED THE FINDINGS NARRATIVELY. MAIN RESULTS: WE INCLUDED 15 RCTS WITH A TOTAL OF 1048 PARTICIPANTS. MOST OF THE TRIALS WERE CONDUCTED IN INDIA, FOLLOWED BY EUROPE AND THE UNITED STATES. THE MAJORITY OF PARTICIPANTS WERE ADULTS OF BOTH SEXES WITH MILD TO MODERATE ASTHMA FOR SIX MONTHS TO MORE THAN 23 YEARS. FIVE STUDIES INCLUDED YOGA BREATHING ALONE, WHILE THE OTHER STUDIES ASSESSED YOGA INTERVENTIONS THAT INCLUDED BREATHING, POSTURE, AND MEDITATION. INTERVENTIONS LASTED FROM TWO WEEKS TO 54 MONTHS, FOR NO MORE THAN SIX MONTHS IN THE MAJORITY OF STUDIES. THE RISK OF BIAS WAS LOW ACROSS ALL DOMAINS IN ONE STUDY AND UNCLEAR OR HIGH IN AT LEAST ONE DOMAIN FOR THE REMAINDER.THERE WAS SOME EVIDENCE THAT YOGA MAY IMPROVE QUALITY OF LIFE (MD IN ASTHMA QUALITY OF LIFE QUESTIONNAIRE (AQLQ) SCORE PER ITEM 0.57 UNITS ON A 7-POINT SCALE, 95% CI 0.37 TO 0.77; 5 STUDIES; 375 PARTICIPANTS), IMPROVE SYMPTOMS (SMD 0.37, 95% CI 0.09 TO 0.65; 3 STUDIES; 243 PARTICIPANTS), AND REDUCE MEDICATION USAGE (RR 5.35, 95% CI 1.29 TO 22.11; 2 STUDIES) IN PEOPLE WITH ASTHMA. THE MD FOR AQLQ SCORE EXCEEDED THE MINIMAL CLINICALLY IMPORTANT DIFFERENCE (MCID) OF 0.5, BUT WHETHER THE MEAN CHANGES EXCEEDED THE MCID FOR ASTHMA SYMPTOMS IS UNCERTAIN DUE TO THE LACK OF AN ESTABLISHED MCID IN THE SEVERITY SCORES USED IN THE INCLUDED STUDIES. THE EFFECTS OF YOGA ON CHANGE FROM BASELINE FORCED EXPIRATORY VOLUME IN ONE SECOND (MD 0.04 LITRES, 95% CI -0.10 TO 0.19; 7 STUDIES; 340 PARTICIPANTS; I(2) = 68%) WERE NOT STATISTICALLY SIGNIFICANT. TWO STUDIES INDICATED IMPROVED ASTHMA CONTROL, BUT DUE TO VERY SIGNIFICANT HETEROGENEITY (I(2) = 98%) WE DID NOT POOL DATA. NO SERIOUS ADVERSE EVENTS ASSOCIATED WITH YOGA WERE REPORTED, BUT THE DATA ON THIS OUTCOME WAS LIMITED. AUTHORS' CONCLUSIONS: WE FOUND MODERATE-QUALITY EVIDENCE THAT YOGA PROBABLY LEADS TO SMALL IMPROVEMENTS IN QUALITY OF LIFE AND SYMPTOMS IN PEOPLE WITH ASTHMA. THERE IS MORE UNCERTAINTY ABOUT POTENTIAL ADVERSE EFFECTS OF YOGA AND ITS IMPACT ON LUNG FUNCTION AND MEDICATION USAGE. RCTS WITH A LARGE SAMPLE SIZE AND HIGH METHODOLOGICAL AND REPORTING QUALITY ARE NEEDED TO CONFIRM THE EFFECTS OF YOGA FOR ASTHMA. 2016 12 2578 44 YOGA FOR HEALTH CARE IN KOREA: A PROTOCOL FOR SYSTEMATIC REVIEW OF CLINICAL TRIALS. THIS SYSTEMATIC REVIEW AIMS TO EVALUATE THE THERAPEUTIC EFFECTS OF YOGA THERAPY USING AN EVIDENCE-BASED APPROACH AND INVESTIGATES THE RELATIONSHIP BETWEEN YOGA AND THE MERIDIAN ENERGIES BASED ON ALL AVAILABLE CLINICAL STUDIES IN KOREA. SIXTEEN ELECTRONIC DATABASES WILL BE SEARCHED FROM THE INCEPTION OF THE STUDY UNTIL JANUARY 2016. ALL CLINICAL EVIDENCES THAT EVALUATE ANY TYPE OF YOGA AND ANY TYPE OF CONTROL IN INDIVIDUALS WITH ANY TYPE OF CONDITION WILL BE ELIGIBLE. THE METHODOLOGICAL QUALITY WILL BE ASSESSED USING THE COCHRANE RISK OF BIAS TOOL FOR RANDOMIZED CLINICAL TRIALS AND THE NEWCASTLE-OTTAWA SCALE FOR NONRANDOMIZED STUDIES. TWO AUTHORS WILL INDEPENDENTLY ASSESS EACH STUDY FOR ELIGIBILITY AND THE RISK OF BIAS, AND THEN THEY WILL EXTRACT THE DATA. WITH ITS EXTENSIVE, UNBIASED SEARCH OF THE KOREAN LITERATURE FROM VARIOUS DATABASES WITHOUT ANY LANGUAGE RESTRICTIONS, THIS SYSTEMATIC REVIEW WILL BE USEFUL FOR BOTH PRACTITIONERS IN THE FIELD OF YOGA RESEARCH AS WELL AS FOR PATIENTS. 2016 13 2121 68 THE EFFECTIVENESS AND CHARACTERISTICS OF PREGNANCY YOGA INTERVENTIONS: A SYSTEMATIC REVIEW PROTOCOL. BACKGROUND: THE PURPOSE OF THIS REVIEW IS TO SYSTEMATICALLY EXAMINE THE REPORTED CLINICAL EFFECTIVENESS OF PREGNANCY YOGA. THE REVIEW WILL USE THE FITT (FREQUENCY, INTENSITY, TIME/DURATION AND TYPE) PRINCIPLE OF PHYSICAL ACTIVITY TO CHARACTERISE THE DIFFERENT TYPES OF YOGA INTERVENTIONS THAT HAVE BEEN EVALUATED IN THE INCLUDED STUDIES. STUDIES WILL BE CATEGORISED AS EFFECTIVENESS OR EFFICACY STUDIES AND THIS CONTINUUM OF EFFICACY VERSUS EFFECTIVENESS WILL BE INCORPORATED INTO THE FULL REVIEW. METHODS/DESIGN: THE FOLLOWING ELECTRONIC DATABASES WILL BE SEARCHED USING A DETAILED SEARCH STRATEGY: MEDLINE, PSYCINFO, EMBASE, CINAHL, WHOLIS, AMED, SCIELO, ASSIA AND WEB OF SCIENCE. RANDOMISED CONTROL TRIALS AND QUASI-EXPERIMENTAL STUDIES EXAMINING PREGNANCY YOGA AND REPORTING ON EFFECT WILL BE INCLUDED. TITLES, ABSTRACTS AND FULL ARTICLES WILL BE SCREENED BY TWO INVESTIGATORS INDEPENDENTLY TO IDENTIFY ELIGIBLE STUDIES. THE COCHRANE COLLABORATION'S RISK OF BIAS ASSESSMENT TOOL WILL BE USED TO ASSESS STUDY QUALITY. QUALITY OF THE EVIDENCE WILL BE EVALUATED USING THE GRADE CRITERIA. A STANDARDISED DATA EXTRACTION FORM WILL BE USED TO EXTRACT DATA. EFFECT SIZES WILL BE ESTIMATED USING MEAN DIFFERENCES FOR CONTINUOUS OUTCOMES, AND RELATIVE RISKS FOR DICHOTOMOUS OUTCOME. WHERE POSSIBLE, POOLING OF EFFECT ESTIMATES WILL BE DONE USING A RANDOM EFFECT MODEL. THE OUTCOMES OF INTEREST ARE QUALITY OF LIFE, STRESS, ANXIETY, DEPRESSION, MODE OF BIRTH, LABOUR DURATION AND PAIN MANAGEMENT IN LABOUR. DISCUSSION: THIS REVIEW WILL SYNTHESISE THE BEST AVAILABLE EVIDENCE ON THE EFFECTIVENESS OF YOGA DURING PREGNANCY AND PROVIDE VALUABLE HIGH-QUALITY INFORMATION FOR CLINICIANS AND HEALTH POLICYMAKERS. FINDINGS WILL BE DISSEMINATED THROUGH PUBLICATION IN A PEER-REVIEWED JOURNAL AND PRESENTATION AT RELEVANT CONFERENCE PROCEEDINGS. THE REVIEW WILL MAKE RECOMMENDATIONS FOR THE APPROPRIATE VOLUME, INTENSITY AND TYPE OF PREGNANCY YOGA FOR MAXIMUM EFFECT AND MAY HAVE IMPLICATIONS FOR POLICY AND PRACTICE RELATING TO PREGNANCY YOGA AS AN INTERVENTION. REGISTRATION: PROSPERO, CRD42019119916. REGISTERED ON 11TH JANUARY 2019. 2019 14 2130 60 THE EFFECTIVENESS OF YOGA TO PREVENT DIABETES MELLITUS TYPE 2: A PROTOCOL FOR SYSTEMATIC REVIEW AND META-ANALYSIS. BACKGROUND: TYPE 2 DIABETES MELLITUS (T2DM) IS BECOMING A LEADING PROBLEM WORLDWIDE. EMERGING REPORTS REVEAL ALARMING EVIDENCE OF INCREASING PREVALENCE OF T2DM THAT HAS REACHED PANDEMIC LEVELS. DESPITE THE SIGNIFICANT INCIDENCE, THERE ARE LIMITED RELIABLE DATA RESOURCES AND COMPREHENSIVE SYSTEMATIC REVIEW AND META-ANALYSIS ON THE EFFECTS OF YOGA ON PEOPLE WHO ARE A PREDIABETIC OR HIGH RISK FOR DEVELOPING T2DM. OBJECTIVE: THE OBJECTIVE OF THIS PROTOCOL IS TO CONDUCT A FULL-SCALE SYSTEMATIC REVIEW AND META-ANALYSES ON THE EFFECTS OF YOGA ON PEOPLE WHO ARE PREDIABETES OR HIGH RISK OF DEVELOPING T2DM. METHODS: THE ARTICLES ENROLLED IN THE STUDY WILL BE RETRIEVED FROM THE ONLINE DATABASES BETWEEN 2002 AND THE DATE THE SEARCHES ARE EXECUTED. THE SEARCHES WILL BE REPEATED JUST BEFORE THE FINAL ANALYSES AND FURTHER RELEVANT STUDIES FOR INCLUSION. WE WILL CONDUCT A BIBLIOGRAPHIC SEARCH IN DATABASES: MEDLINE/PUBMED, SCOPUS, COCHRANE LIBRARY, EBSCO, AND INDMED USING KEYWORDS INCLUDING PREDIABETES STATE, HIGH RISK FOR DIABETES, METABOLIC SYNDROME, AND YOGA. A DEFINED SEARCH STRATEGY WILL BE IMPLEMENTED ALONG WITH SELECTION CRITERIA TO OBTAIN FULL-TEXT ARTICLES OF RELEVANT STUDIES. THIS STUDY PROTOCOL WAS PREPARED ACCORDING TO THE PREFERRED REPORTING ITEMS FOR SYSTEMATIC REVIEWS AND META-ANALYSIS FOR PROTOCOLS 2015 GUIDELINES. THERE WILL BE NO LANGUAGE RESTRICTIONS. ETHICS AND DISSEMINATION: THE PROPOSED STUDY WILL BE BASED ON PUBLISHED STUDIES AND PUBLICLY AVAILABLE ANONYMIZED DATA WITHOUT DIRECTLY INVOLVING HUMAN PARTICIPANTS AND THEREFORE REQUIRES NEITHER FORMAL HUMAN ETHICAL REVIEW NOR APPROVAL BY A HUMAN RESEARCH ETHICS COMMITTEE. WE PUBLISHED AN OUTLINE OF THE PROTOCOL IN THE INTERNATIONAL PROSPECTIVE REGISTER OF SYSTEMATIC REVIEWS (PROSPERO) IN 2018. WE PLAN TO DISSEMINATE THE FINDINGS OF THIS SYSTEMATIC REVIEW AND META-ANALYSIS THROUGH PUBLICATION IN A PEER-REVIEWED JOURNAL AND PRESENTATION AT RELEVANT CONFERENCE PROCEEDINGS. IN ADDITION, WE BELIEVE THE RESULTS OF THE SYSTEMATIC REVIEW WILL HAVE IMPLICATIONS FOR POLICY AND PRACTICE. WE WILL PREPARE POLICYMAKER SUMMARY USING A VALIDATED FORMAT, DISSEMINATE THROUGH SOCIAL MEDIA AND EMAIL DISCUSSION GROUPS. REVIEW REGISTRATION NUMBER: PROSPERO REGISTRATION NUMBER CRD 42018106657. 2019 15 1064 44 EFFECTS OF YOGA ON IMMUNE FUNCTION: A SYSTEMATIC REVIEW OF RANDOMIZED CONTROLLED TRIALS. OBJECTIVE: THIS SYSTEMATIC REVIEW ATTEMPTS TO CONFIRM THE ADDED EVIDENCE TO ASSESS THE EFFECT OF YOGA ON IMMUNE FUNCTION. METHODS: THE COCHRANE LIBRARY, EMBASE, PSYCINFO, PUBMED, AND WEB OF SCIENCE ELECTRONIC DATABASES WERE SEARCHED ACCORDING TO THE PRISRMA METHOD TO IDENTIFY RANDOMIZED CONTROLLED TRIALS (RCTS) ON THE IMMUNOLOGICAL EFFECTS OF YOGA PUBLISHED IN THE ENGLISH LANGUAGE FROM JANUARY 1, 2017, TO DECEMBER 31, 2020. THIS REVIEW COULD ONLY BE DESCRIPTIVELY SUMMARIZED BECAUSE OF HETEROGENEITY OF THE INCLUDED RCTS. RESULTS: ELEVEN POTENTIAL TRIALS WERE IDENTIFIED AND INCLUDED IN THIS REVIEW. QUALITY APPRAISAL OF INCLUDED TRIALS RANGED FROM 3 FOR UNCLEAR RISK OF BIAS AND 8 FOR HIGH RISK OF BIAS. THERE IS EVIDENCE FROM 11 RCTS THAT YOGA MAY HAVE FAVORABLE EFFECTS FOR REDUCING THE LEVELS OF ANTI-INFLAMMATORY MARKERS. CONCLUSIONS: YOGA MAY BE USED AS A COMPLEMENTARY INTERVENTION FOR CLINICAL POPULATIONS OR HEALTHY INDIVIDUALS. 2021 16 308 58 AN EVIDENCE MAP OF YOGA FOR LOW BACK PAIN. OBJECTIVE: YOGA IS BEING INCREASINGLY STUDIED AS A TREATMENT STRATEGY FOR A VARIETY OF DIFFERENT CLINICAL CONDITIONS, INCLUDING LOW BACK PAIN (LBP). WE SET OUT TO CONDUCT AN EVIDENCE MAP OF YOGA FOR THE TREATMENT, PREVENTION AND RECURRENCE OF ACUTE OR CHRONIC LOW BACK PAIN (CLBP). METHODS: WE SEARCHED MEDLINE, COCHRANE DATABASE OF SYSTEMATIC REVIEWS, EMBASE, ALLIED AND COMPLEMENTARY MEDICINE DATABASE AND CLINICALTRIALS.GOV FOR RANDOMIZED CONTROLLED TRIALS (RCT), SYSTEMATIC REVIEWS OR PLANNED STUDIES ON THE TREATMENT OR PREVENTION OF ACUTE BACK PAIN OR CLBP. TWO INDEPENDENT REVIEWERS SCREENED PAPERS FOR INCLUSION, EXTRACTED DATA AND ASSESSED THE QUALITY OF INCLUDED STUDIES. RESULTS: THREE ELIGIBLE SYSTEMATIC REVIEWS WERE IDENTIFIED THAT INCLUDED 10 RCTS (N=956) THAT EVALUATED YOGA FOR NON-SPECIFIC CLBP. WE DID NOT IDENTIFY ADDITIONAL RCTS BEYOND THOSE INCLUDED IN THE SYSTEMATIC REVIEWS. OUR SEARCH OF CLINICALTRIALS.GOV IDENTIFIED ONE SMALL (N=10) UNPUBLISHED TRIAL AND ONE LARGE (N=320) PLANNED CLINICAL TRIAL. THE MOST RECENT GOOD QUALITY SYSTEMATIC REVIEW INDICATED SIGNIFICANT EFFECTS FOR SHORT- AND LONG-TERM PAIN REDUCTION (N=6 TRIALS; STANDARDIZED MEAN DIFFERENCE [SMD] -0.48; 95% CI, -0.65 TO -0.31; I(2)=0% AND N=5; SMD -0.33; 95% CI, -0.59 TO -0.07; I(2)=48%, RESPECTIVELY). LONG-TERM EFFECTS FOR BACK SPECIFIC DISABILITY WERE ALSO IDENTIFIED (N=5; SMD -0.35; 95% CI, -0.55 TO -0.15; I(2)=20%). NO STUDIES WERE IDENTIFIED EVALUATING YOGA FOR PREVENTION OR TREATMENT OF ACUTE LBP. CONCLUSION: EVIDENCE SUGGESTS BENEFIT OF YOGA IN MIDLIFE ADULTS WITH NON-SPECIFIC CLBP FOR SHORT- AND LONG-TERM PAIN AND BACK-SPECIFIC DISABILITY, BUT THE EFFECTS OF YOGA FOR HEALTH-RELATED QUALITY OF LIFE, WELL- BEING AND ACUTE LBP ARE UNCERTAIN. WITHOUT ADDITIONAL STUDIES, FURTHER SYSTEMATIC REVIEWS ARE UNLIKELY TO BE INFORMATIVE. 2016 17 2620 107 YOGA FOR STROKE REHABILITATION. BACKGROUND: STROKE IS A MAJOR HEALTH ISSUE AND CAUSE OF LONG-TERM DISABILITY AND HAS A MAJOR EMOTIONAL AND SOCIOECONOMIC IMPACT. THERE IS A NEED TO EXPLORE OPTIONS FOR LONG-TERM SUSTAINABLE INTERVENTIONS THAT SUPPORT STROKE SURVIVORS TO ENGAGE IN MEANINGFUL ACTIVITIES TO ADDRESS LIFE CHALLENGES AFTER STROKE. REHABILITATION FOCUSES ON RECOVERY OF FUNCTION AND COGNITION TO THE MAXIMUM LEVEL ACHIEVABLE, AND MAY INCLUDE A WIDE RANGE OF COMPLEMENTARY STRATEGIES INCLUDING YOGA.YOGA IS A MIND-BODY PRACTICE THAT ORIGINATED IN INDIA, AND WHICH HAS BECOME INCREASINGLY WIDESPREAD IN THE WESTERN WORLD. RECENT EVIDENCE HIGHLIGHTS THE POSITIVE EFFECTS OF YOGA FOR PEOPLE WITH A RANGE OF PHYSICAL AND PSYCHOLOGICAL HEALTH CONDITIONS. A RECENT NON-COCHRANE SYSTEMATIC REVIEW CONCLUDED THAT YOGA CAN BE USED AS SELF-ADMINISTERED PRACTICE IN STROKE REHABILITATION. OBJECTIVES: TO ASSESS THE EFFECTIVENESS OF YOGA, AS A STROKE REHABILITATION INTERVENTION, ON RECOVERY OF FUNCTION AND QUALITY OF LIFE (QOL). SEARCH METHODS: WE SEARCHED THE COCHRANE STROKE GROUP TRIALS REGISTER (LAST SEARCHED JULY 2017), COCHRANE CENTRAL REGISTER OF CONTROLLED TRIALS (CENTRAL) (LAST SEARCHED JULY 2017), MEDLINE (TO JULY 2017), EMBASE (TO JULY 2017), CINAHL (TO JULY 2017), AMED (TO JULY 2017), PSYCINFO (TO JULY 2017), LILACS (TO JULY 2017), SCIELO (TO JULY 2017), INDMED (TO JULY 2017), OTSEEKER (TO JULY 2017) AND PEDRO (TO JULY 2017). WE ALSO SEARCHED FOUR TRIALS REGISTERS, AND ONE CONFERENCE ABSTRACTS DATABASE. WE SCREENED REFERENCE LISTS OF RELEVANT PUBLICATIONS AND CONTACTED AUTHORS FOR ADDITIONAL INFORMATION. SELECTION CRITERIA: WE INCLUDED RANDOMISED CONTROLLED TRIALS (RCTS) THAT COMPARED YOGA WITH A WAITING-LIST CONTROL OR NO INTERVENTION CONTROL IN STROKE SURVIVORS. DATA COLLECTION AND ANALYSIS: TWO REVIEW AUTHORS INDEPENDENTLY EXTRACTED DATA FROM THE INCLUDED STUDIES. WE PERFORMED ALL ANALYSES USING REVIEW MANAGER (REVMAN). ONE REVIEW AUTHOR ENTERED THE DATA INTO REVMAN; ANOTHER CHECKED THE ENTRIES. WE DISCUSSED DISAGREEMENTS WITH A THIRD REVIEW AUTHOR UNTIL CONSENSUS WAS REACHED. WE USED THE COCHRANE 'RISK OF BIAS' TOOL. WHERE WE CONSIDERED STUDIES TO BE SUFFICIENTLY SIMILAR, WE CONDUCTED A META-ANALYSIS BY POOLING THE APPROPRIATE DATA. FOR OUTCOMES FOR WHICH IT WAS INAPPROPRIATE OR IMPOSSIBLE TO POOL QUANTITATIVELY, WE CONDUCTED A DESCRIPTIVE ANALYSIS AND PROVIDED A NARRATIVE SUMMARY. MAIN RESULTS: WE INCLUDED TWO RCTS INVOLVING 72 PARTICIPANTS. SIXTY-NINE PARTICIPANTS WERE INCLUDED IN ONE META-ANALYSIS (BALANCE). BOTH TRIALS ASSESSED QOL, ALONG WITH SECONDARY OUTCOMES MEASURES RELATING TO MOVEMENT AND PSYCHOLOGICAL OUTCOMES; ONE ALSO MEASURED DISABILITY.IN ONE STUDY THE STROKE IMPACT SCALE WAS USED TO MEASURE QOL ACROSS SIX DOMAINS, AT BASELINE AND POST-INTERVENTION. THE EFFECT OF YOGA ON FIVE DOMAINS (PHYSICAL, EMOTION, COMMUNICATION, SOCIAL PARTICIPATION, STROKE RECOVERY) WAS NOT SIGNIFICANT; HOWEVER, THE EFFECT OF YOGA ON THE MEMORY DOMAIN WAS SIGNIFICANT (MEAN DIFFERENCE (MD) 15.30, 95% CONFIDENCE INTERVAL (CI) 1.29 TO 29.31, P = 0.03), THE EVIDENCE FOR THIS FINDING WAS VERY LOW GRADE. IN THE SECOND STUDY, QOL WAS ASSESSED USING THE STROKE-SPECIFC QOL SCALE; NO SIGNIFICANT EFFECT WAS FOUND.SECONDARY OUTCOMES INCLUDED MOVEMENT, STRENGTH AND ENDURANCE, AND PSYCHOLOGICAL VARIABLES, PAIN, AND DISABILITY.BALANCE WAS MEASURED IN BOTH STUDIES USING THE BERG BALANCE SCALE; THE EFFECT OF INTERVENTION WAS NOT SIGNIFICANT (MD 2.38, 95% CI -1.41 TO 6.17, P = 0.22). SENSITITIVY ANALYSIS DID NOT ALTER THE DIRECTION OF EFFECT. ONE STUDY MEASURED BALANCE SELF-EFFICACY, USING THE ACTIVITIES-SPECIFIC BALANCE CONFIDENCE SCALE (MD 10.60, 95% CI -7.08,= TO 28.28, P = 0.24); THE EFFECT OF INTERVENTION WAS NOT SIGNIFICANT; THE EVIDENCE FOR THIS FINDING WAS VERY LOW GRADE.ONE STUDY MEASURED GAIT USING THE COMFORTABLE SPEED GAIT TEST (MD 1.32, 95% CI -1.35 TO 3.99, P = 0.33), AND MOTOR FUNCTION USING THE MOTOR ASSESSMENT SCALE (MD -4.00, 95% CI -12.42 TO 4.42, P = 0.35); NO SIGNIFICANT EFFECT WAS FOUND BASED ON VERY LOW-GRADE EVIDENCE.ONE STUDY MEASURED DISABILITY USING THE MODIFIED RANKIN SCALE (MRS) BUT REPORTED ONLY WHETHER PARTICIPANTS WERE INDEPENDENT OR DEPENDENT. NO SIGNIFICANT EFFECT WAS FOUND: (ODDS RATIO (OR) 2.08, 95% CI 0.50 TO 8.60, P = 0.31); THE EVIDENCE FOR THIS FINDING WAS VERY LOW GRADE.ANXIETY AND DEPRESSION WERE MEASURED IN ONE STUDY. THREE MEASURES WERE USED: THE GERIATRIC DEPRESSION SCALE-SHORT FORM (GCDS15), AND TWO FORMS OF STATE TRAIT ANXIETY INVENTORY (STAI, FORM Y) TO MEASURE STATE ANXIETY (I.E. ANXIETY EXPERIENCED IN RESPONSE TO STRESSFUL SITUATIONS) AND TRAIT ANXIETY (I.E. ANXIETY ASSOCIATED WITH CHRONIC PSYCHOLOGICAL DISORDERS). NO SIGNIFICANT EFFECT WAS FOUND FOR DEPRESSION (GDS15, MD -2.10, 95% CI -4.70 TO 0.50, P = 0.11) OR FOR TRAIT ANXIETY (STAI-Y2, MD -6.70, 95% CI -15.35 TO 1.95, P = 0.13), BASED ON VERY LOW-GRADE EVIDENCE. HOWEVER, A SIGNIFICANT EFFECT WAS FOUND FOR STATE ANXIETY: STAI-Y1 (MD -8.40, 95% CI -16.74 TO -0.06, P = 0.05); THE EVIDENCE FOR THIS FINDING WAS VERY LOW GRADE.NO ADVERSE EVENTS WERE REPORTED.QUALITY OF THE EVIDENCEWE ASSESSED THE QUALITY OF THE EVIDENCE USING GRADE. OVERALL, THE QUALITY OF THE EVIDENCE WAS VERY LOW, DUE TO THE SMALL NUMBER OF TRIALS INCLUDED IN THE REVIEW BOTH OF WHICH WERE JUDGED TO BE AT HIGH RISK OF BIAS, PARTICULARLY IN RELATION TO INCOMPLETENESS OF DATA AND SELECTIVE REPORTING, AND ESPECIALLY REGARDING THE REPRESENTATIVE NATURE OF THE SAMPLE IN ONE STUDY. AUTHORS' CONCLUSIONS: YOGA HAS THE POTENTIAL FOR BEING INCLUDED AS PART OF PATIENT-CENTRED STROKE REHABILITATION. HOWEVER, THIS REVIEW HAS IDENTIFIED INSUFFICIENT INFORMATION TO CONFIRM OR REFUTE THE EFFECTIVENESS OR SAFETY OF YOGA AS A STROKE REHABILITATION TREATMENT. FURTHER LARGE-SCALE METHODOLOGICALLY ROBUST TRIALS ARE REQUIRED TO ESTABLISH THE EFFECTIVENESS OF YOGA AS A STROKE REHABILITATION TREATMENT. 2017 18 317 50 AN INTEGRATED METHODOLOGY TO ASSESS COMPLIANCE WITH DELPHI SURVEY KEY COMPONENTS OF YOGA INTERVENTIONS FOR MUSCULOSKELETAL CONDITIONS AS APPLIED IN A SYSTEMATIC REVIEW OF FIBROMYALGIA STUDIES. OBJECTIVE: THE OBJECTIVE OF THIS ARTICLE WAS TO PRESENT A METHODOLOGY INCORPORATING EXISTING GUIDELINES AND TOOLS FOR SYSTEMATIC REVIEWS AND TO EVALUATE THE DELPHI SURVEY 33 KEY COMPONENT RECOMMENDATIONS OF YOGA INTERVENTIONS FOR MUSCULOSKELETAL CONDITIONS AS A TOOL FOR A SYSTEMATIC REVIEW IN FIBROMYALGIA STUDIES. DATA SOURCES: DATABASES SEARCHED INCLUDED PUBMED, OVID MEDLINE, PSYCHINFO, THE COCHRANE LIBRARY, CINAHL, ALT HEALTHWATCH, PEDRO, AND WEB OF SCIENCE. ARTICLE SELECTION: SELECTED WERE ARTICLES PUBLISHED BETWEEN NOVEMBER 14, 2004 AND NOVEMBER 13, 2014, WRITTEN IN ENGLISH, REPORTING ORIGINAL RESEARCH OF YOGA INTERVENTIONS FOR ADULTS WITH FIBROMYALGIA. DATA EXTRACTION AND SYNTHESIS: SIX ARTICLES MET THE INCLUSION CRITERIA, REVEALING THAT THREE YOGA STYLES ("RELAXING" YOGA, YOGA OF AWARENESS, AND HATHA YOGA) HAVE BEEN ASSESSED IN PERSONS WITH FIBROMYALGIA. OVERALL, REPORTING COMPLIANCE WITH THE 33 KEY COMPONENTS RANGED FROM 39.4% TO 84.8%, WITH A MEAN ADHERENCE RATE OF 62.63% +/- 17.74. NONE OF THE AUTHORS USED AN ACCEPTED REPORTING GUIDELINE; SPECIFIC COMPONENTS OF ASANA, PRANAYAMA, RELAXATION, AND MINDFULNESS PRACTICES THAT WOULD HAVE BEEN INCORPORATED INTO THE INTERVENTIONS TESTED WERE IDENTIFIED IN ONLY 33.33% OF THE ARTICLES REVIEWED; AND NONE OF THE ARTICLES INCLUDED DETAILED, REPLICABLE DESCRIPTIONS OF THE INTERVENTIONS. CONCLUSIONS: THIS SYSTEMATIC REVIEW SUPPORTS THE NEED FOR COMPREHENSIVE YOGA RESEARCH GUIDELINES. FINDINGS REVEAL A LACK OF REPORTING OF INTERVENTION DETAILS, THE NEED TO REPORT A DISEASE-SPECIFIC RATIONALE FOR SELECTION OF THE PARTICULAR YOGA STYLE USED FOR THE INTERVENTION, AND THAT A LIMITED NUMBER OF YOGA STYLES HAVE BEEN INVESTIGATED IN PERSONS WITH FIBROMYALGIA. 2016 19 2636 107 YOGA FOR TREATING URINARY INCONTINENCE IN WOMEN. BACKGROUND: URINARY INCONTINENCE IN WOMEN IS ASSOCIATED WITH POOR QUALITY OF LIFE AND DIFFICULTIES IN SOCIAL, PSYCHOLOGICAL AND SEXUAL FUNCTIONING. THE CONDITION MAY AFFECT UP TO 15% OF MIDDLE-AGED OR OLDER WOMEN IN THE GENERAL POPULATION. CONSERVATIVE TREATMENTS SUCH AS LIFESTYLE INTERVENTIONS, BLADDER TRAINING AND PELVIC FLOOR MUSCLE TRAINING (USED EITHER ALONE OR IN COMBINATION WITH OTHER INTERVENTIONS) ARE THE INITIAL APPROACHES TO THE MANAGEMENT OF URINARY INCONTINENCE. MANY WOMEN ARE INTERESTED IN ADDITIONAL TREATMENTS SUCH AS YOGA, A SYSTEM OF PHILOSOPHY, LIFESTYLE AND PHYSICAL PRACTICE THAT ORIGINATED IN ANCIENT INDIA. OBJECTIVES: TO ASSESS THE EFFECTS OF YOGA FOR TREATING URINARY INCONTINENCE IN WOMEN. SEARCH METHODS: WE SEARCHED THE COCHRANE INCONTINENCE AND COCHRANE COMPLEMENTARY MEDICINE SPECIALISED REGISTERS. WE SEARCHED THE WORLD HEALTH ORGANIZATION INTERNATIONAL CLINICAL TRIALS REGISTRY PLATFORM (WHO ICTRP) AND CLINICALTRIALS.GOV TO IDENTIFY ANY ONGOING OR UNPUBLISHED STUDIES. WE HANDSEARCHED PROCEEDINGS OF THE INTERNATIONAL CONGRESS ON COMPLEMENTARY MEDICINE RESEARCH AND THE EUROPEAN CONGRESS FOR INTEGRATIVE MEDICINE. WE SEARCHED THE NHS ECONOMIC EVALUATION DATABASE FOR ECONOMIC STUDIES, AND SUPPLEMENTED THIS SEARCH WITH SEARCHES FOR ECONOMICS STUDIES IN MEDLINE AND EMBASE FROM 2015 ONWARDS. DATABASE SEARCHES ARE UP-TO-DATE AS OF 21 JUNE 2018. SELECTION CRITERIA: RANDOMISED CONTROLLED TRIALS IN WOMEN DIAGNOSED WITH URINARY INCONTINENCE IN WHICH ONE GROUP WAS ALLOCATED TO TREATMENT WITH YOGA. DATA COLLECTION AND ANALYSIS: TWO REVIEW AUTHORS INDEPENDENTLY SCREENED TITLES AND ABSTRACTS OF ALL RETRIEVED ARTICLES, SELECTED STUDIES FOR INCLUSION, EXTRACTED DATA, ASSESSED RISK OF BIAS AND EVALUATED THE CERTAINTY OF THE EVIDENCE FOR EACH REPORTED OUTCOME. ANY DISAGREEMENTS WERE RESOLVED BY CONSENSUS. WE PLANNED TO COMBINE CLINICALLY COMPARABLE STUDIES IN REVIEW MANAGER 5 USING RANDOM-EFFECTS META-ANALYSIS AND TO CARRY OUT SENSITIVITY AND SUBGROUP ANALYSES. WE PLANNED TO CREATE A TABLE LISTING ECONOMIC STUDIES ON YOGA FOR INCONTINENCE BUT NOT CARRY OUT ANY ANALYSES ON THESE STUDIES. MAIN RESULTS: WE INCLUDED TWO STUDIES (INVOLVING A TOTAL OF 49 WOMEN). EACH STUDY COMPARED YOGA TO A DIFFERENT COMPARATOR, THEREFORE WE WERE UNABLE TO COMBINE THE DATA IN A META-ANALYSIS. A THIRD STUDY THAT HAS BEEN COMPLETED BUT NOT YET FULLY REPORTED IS AWAITING ASSESSMENT.ONE INCLUDED STUDY WAS A SIX-WEEK STUDY COMPARING YOGA TO A WAITING LIST IN 19 WOMEN WITH EITHER URGENCY URINARY INCONTINENCE OR STRESS URINARY INCONTINENCE. WE JUDGED THE CERTAINTY OF THE EVIDENCE FOR ALL REPORTED OUTCOMES AS VERY LOW DUE TO PERFORMANCE BIAS, DETECTION BIAS, AND IMPRECISION. THE NUMBER OF WOMEN REPORTING CURE WAS NOT REPORTED. WE ARE UNCERTAIN WHETHER YOGA RESULTS IN SATISFACTION WITH CURE OR IMPROVEMENT OF INCONTINENCE (RISK RATIO (RR) 6.33, 95% CONFIDENCE INTERVAL (CI) 1.44 TO 27.88; AN INCREASE OF 592 FROM 111 PER 1000, 95% CI 160 TO 1000). WE ARE UNCERTAIN WHETHER THERE IS A DIFFERENCE BETWEEN YOGA AND WAITING LIST IN CONDITION-SPECIFIC QUALITY OF LIFE AS MEASURED ON THE INCONTINENCE IMPACT QUESTIONNAIRE SHORT FORM (MEAN DIFFERENCE (MD) 1.74, 95% CI -33.02 TO 36.50); THE NUMBER OF MICTURITIONS (MD -0.77, 95% CI -2.13 TO 0.59); THE NUMBER OF INCONTINENCE EPISODES (MD -1.57, 95% CI -2.83 TO -0.31); OR THE BOTHERSOMENESS OF INCONTINENCE AS MEASURED ON THE UROGENITAL DISTRESS INVENTORY 6 (MD -0.90, 95% CI -1.46 TO -0.34). THERE WAS NO EVIDENCE OF A DIFFERENCE IN THE NUMBER OF WOMEN WHO EXPERIENCED AT LEAST ONE ADVERSE EVENT (RISK DIFFERENCE 0%, 95% CI -38% TO 38%; NO DIFFERENCE FROM 222 PER 1000, 95% CI 380 FEWER TO 380 MORE).THE SECOND INCLUDED STUDY WAS AN EIGHT-WEEK STUDY IN 30 WOMEN WITH URGENCY URINARY INCONTINENCE THAT COMPARED MINDFULNESS-BASED STRESS REDUCTION (MBSR) TO AN ACTIVE CONTROL INTERVENTION OF YOGA CLASSES. THE STUDY WAS UNBLINDED, AND THERE WAS HIGH ATTRITION FROM BOTH STUDY ARMS FOR ALL OUTCOME ASSESSMENTS. WE JUDGED THE CERTAINTY OF THE EVIDENCE FOR ALL REPORTED OUTCOMES AS VERY LOW DUE TO PERFORMANCE BIAS, ATTRITION BIAS, IMPRECISION AND INDIRECTNESS. THE NUMBER OF WOMEN REPORTING CURE WAS NOT REPORTED. WE ARE UNCERTAIN WHETHER WOMEN IN THE YOGA GROUP WERE LESS LIKELY TO REPORT IMPROVEMENT IN INCONTINENCE AT EIGHT WEEKS COMPARED TO WOMEN IN THE MBSR GROUP (RR 0.09, 95% CI 0.01 TO 1.43; A DECREASE OF 419 FROM 461 PER 1000, 95% CI 5 TO 660). WE ARE UNCERTAIN ABOUT THE EFFECT OF MBSR COMPARED TO YOGA ON REPORTS OF CURE OR IMPROVEMENT IN INCONTINENCE, IMPROVEMENT IN CONDITION-SPECIFIC QUALITY OF LIFE MEASURED ON THE OVERACTIVE BLADDER HEALTH-RELATED QUALITY OF LIFE SCALE, REDUCTION IN INCONTINENCE EPISODES OR REDUCTION IN BOTHERSOMENESS OF INCONTINENCE AS MEASURED ON THE OVERACTIVE BLADDER SYMPTOM AND QUALITY OF LIFE-SHORT FORM AT EIGHT WEEKS. THE STUDY DID NOT REPORT ON ADVERSE EFFECTS. AUTHORS' CONCLUSIONS: WE IDENTIFIED FEW TRIALS ON YOGA FOR INCONTINENCE, AND THE EXISTING TRIALS WERE SMALL AND AT HIGH RISK OF BIAS. IN ADDITION, WE DID NOT FIND ANY STUDIES OF ECONOMIC OUTCOMES RELATED TO YOGA FOR URINARY INCONTINENCE. DUE TO THE LACK OF EVIDENCE TO ANSWER THE REVIEW QUESTION, WE ARE UNCERTAIN WHETHER YOGA IS USEFUL FOR WOMEN WITH URINARY INCONTINENCE. ADDITIONAL, WELL-CONDUCTED TRIALS WITH LARGER SAMPLE SIZES ARE NEEDED. 2019 20 2465 57 YOGA AS A THERAPEUTIC INTERVENTION: A BIBLIOMETRIC ANALYSIS OF PUBLISHED RESEARCH STUDIES FROM 1967 TO 2013. OBJECTIVE: A COMPREHENSIVE BIBLIOMETRIC ANALYSIS WAS CONDUCTED ON PUBLICATIONS FOR YOGA THERAPY RESEARCH IN CLINICAL POPULATIONS. METHODS: MAJOR ELECTRONIC DATABASES WERE SEARCHED FOR ARTICLES IN ALL LANGUAGES PUBLISHED BETWEEN 1967 AND 2013. DATABASES INCLUDED PUBMED, PSYCHINFO, MEDLINE, INDMED, INDIAN CITATION INDEX, INDEX MEDICUS FOR SOUTH-EAST ASIA REGION, WEB OF KNOWLEDGE, EMBASE, EBSCO, AND GOOGLE SCHOLAR. NONINDEXED JOURNALS WERE SEARCHED MANUALLY. KEY SEARCH WORDS INCLUDED YOGA, YOGA THERAPY, PRANAYAMA, ASANA. ALL STUDIES MET THE DEFINITION OF A CLINICAL TRIAL. ALL STYLES OF YOGA WERE INCLUDED. THE AUTHORS EXTRACTED THE DATA. RESULTS: A TOTAL OF 486 ARTICLES MET THE INCLUSION CRITERIA AND WERE PUBLISHED IN 217 DIFFERENT PEER-REVIEWED JOURNALS FROM 29 DIFFERENT COUNTRIES ON 28,080 STUDY PARTICIPANTS. THE PRIMARY RESULT OBSERVED IS THE THREE-FOLD INCREASE IN NUMBER OF PUBLICATIONS SEEN IN THE LAST 10 YEARS, INCLUSIVE OF ALL STUDY DESIGNS. OVERALL, 45% OF THE STUDIES PUBLISHED WERE RANDOMIZED CONTROLLED TRIALS, 18% WERE CONTROLLED STUDIES, AND 37% WERE UNCONTROLLED STUDIES. MOST PUBLICATIONS ORIGINATED FROM INDIA (N=258), FOLLOWED BY THE UNITED STATES (N=122) AND CANADA (N=13). THE TOP THREE DISORDERS ADDRESSED BY YOGA INTERVENTIONS WERE MENTAL HEALTH, CARDIOVASCULAR DISEASE, AND RESPIRATORY DISEASE. CONCLUSION: A SURGE IN PUBLICATIONS ON YOGA TO MITIGATE DISEASE-RELATED SYMPTOMS IN CLINICAL POPULATIONS HAS OCCURRED DESPITE CHALLENGES FACING THE FIELD OF YOGA RESEARCH, WHICH INCLUDE STANDARDIZATION AND LIMITATIONS IN FUNDING, TIME, AND RESOURCES. THE POPULATION AT LARGE HAS OBSERVED A PARALLEL SURGE IN THE USE OF YOGA OUTSIDE OF CLINICAL PRACTICE. THE USE OF YOGA AS A COMPLEMENTARY THERAPY IN CLINICAL PRACTICE MAY LEAD TO HEALTH BENEFITS BEYOND TRADITIONAL TREATMENT ALONE; HOWEVER, TO EFFECT CHANGES IN HEALTH CARE POLICY, MORE HIGH-QUALITY, EVIDENCE-BASED RESEARCH IS NEEDED. 2015