1  833 131 EFFECT OF YOGA ON OXIDATIVE STRESS IN ELDERLY WITH GRADE-I HYPERTENSION: A RANDOMIZED CONTROLLED STUDY. BACKGROUND AND OBJECTIVES: HYPERTENSION, ESPECIALLY IN ELDERLY IS A STRONG RISK FACTOR FOR CARDIOVASCULAR MORTALITY AND MORBIDITY. OXIDATIVE STRESS HAS BEEN IMPLICATED AS ONE OF THE UNDERLYING CAUSE OF HYPERTENSION. YOGA HAS BEEN FOUND TO CONTROL HYPERTENSION IN THE ELDERLY, BUT THE UNDERLYING BENEFITS OF MECHANISM IN RELATION TO OXIDATIVE STRESS REGULATION REMAINS UNCLEAR. THE PURPOSE OF THE STUDY WAS TO INVESTIGATE THE EFFECT OF YOGA ON OXIDATIVE STRESS IN ELDERLY WITH GRADE-I HYPERTENSION. METHODS: AN OPEN PARALLEL-ARM RANDOMISED CONTROLLED STUDY WAS CONDUCTED AT BLDE UNIVERSITY'S SHRI B.M.PATIL MEDICAL COLLEGE, HOSPITAL AND RESEARCH CENTRE, INDIA ON ELDERLY MALE INDIVIDUALS WITH GRADE-I HYPERTENSION (N=57, AGE 60-80 YEARS). STUDY (YOGA) GROUP WAS ASSIGNED FOR YOGA INTERVENTION AND CONTROL GROUP FOR WALKING FOR ONE HOUR IN THE MORNING FOR SIX DAYS IN A WEEK FOR THREE MONTHS UNDER THE SUPERVISION OF YOGA INSTRUCTOR AND PHYSICAL TRAINING INSTRUCTOR RESPECTIVELY. SERUM MALONDIALDEHYDE (MDA) AS AN INDICATOR OF OXIDATIVE STRESS AND ANTIOXIDANTS SUCH AS SERUM SUPEROXIDE DISMUTASE (SOD), REDUCED GLUTATHIONE (GSH) AND VITAMIN C LEVELS WERE ESTIMATED. RESULTS: YOGA PRACTICE FOR THREE MONTHS HAS SIGNIFICANTLY REDUCED SERUM MDA LEVEL (P<0.001), AND ENHANCED ANTIOXIDANTS LEVEL SUCH AS SOD ACTIVITY (P=0.007), SERUM GSH (P=0.002) AND VITAMIN C (P=0.002). IN THE CONTROL GROUP, WE OBSERVED A SIGNIFICANT INCREASE IN SERUM MDA LEVEL (P=0.04) AND REDUCTION IN SERUM VITAMIN C LEVEL (P=0.015) WITH NO SIGNIFICANT DIFFERENCE IN THE SOD ACTIVITY AND GSH LEVEL. CONCLUSION: THESE FINDINGS SUGGEST THAT YOGA IS AN EFFECTIVE MEANS TO REDUCE OXIDATIVE STRESS AND TO IMPROVE ANTIOXIDANT DEFENSE IN ELDERLY HYPERTENSIVE INDIVIDUALS.	2014	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
2 1690  47 OXIDATIVE STRESS INDUCED DAMAGE TO PATERNAL GENOME AND IMPACT OF MEDITATION AND YOGA - CAN IT REDUCE INCIDENCE OF CHILDHOOD CANCER? BACKGROUND: SPERM DNA DAMAGE IS UNDERLYING AETIOLOGY OF POOR IMPLANTATION AND PREGNANCY RATES BUT ALSO AFFECTS HEALTH OF OFFSPRING AND MAY ALSO RESULT IN DENOVO MUTATIONS IN GERM LINE AND POST FERTILIZATION. THIS MAY RESULT IN COMPLEX DISEASES, POLYGENIC DISORDERS AND CHILDHOOD CANCERS. CHILDHOOD CANCER LIKE RETINOBLASTOMA (RB) IS MORE PREVALENT IN DEVELOPING COUNTRIES AND THE INCIDENCE OF RB HAS INCREASED MORE THAN THREE FOLD IN INDIA IN THE LAST DECADE. RECENT STUDIES HAVE DOCUMENTED INCREASED INCIDENCE OF CANCERS IN CHILDREN BORN TO FATHERS WHO CONSUME ALCOHOL IN EXCESS AND TOBACCO OR WHO WERE CONCEIVED BY ASSISTED CONCEPTION. THE AETIOLOGY OF CHILDHOOD CANCER AND INCREASED DISEASE BURDEN IN THESE CHILDREN IS LIN KED TO OXIDATIVE STRESS (OS) AND OXIDATIVE DNA DAMAGE( ODD) IN SPERM OF THEIR FATHERS. THOUGH SEVERAL ANTIOXIDANTS ARE IN USE TO COMBAT OXIDATIVE STRESS, THE EFFECT OF MAJORITY OF THESE FORMULATIONS ON DNA IS NOT KNOWN. YOGA AND MEDITATION CAUSE SIGNIFICANT DECLINE IN OS AND ODD AND AID IN REGULATING OS LEVELS SUCH THAT REACTIVE OXYGEN SPEUES MEDITATED SIGNAL TRANSDUCTION, GENE EXPRESSION AND SEVERAL OTHER PHYSIOLOGICAL FUNCTIONS ARE NOT DISRUPTED. THUS, THIS STUDY AIMED TO ANALYZE SPERM ODD AS A POSSIBLE ETIOLOGICAL FACTOR IN CHILDHOOD CANCER AND ROLE OF SIMPLE LIFE STYLE INTERVENTIONS LIKE YOGA AND MEDITATION IN SIGNIFICANTLY DECREASING SEMINAL OXIDATIVE STRESS AND OXIDATIVE DNA DAMAGE AND THEREBY DECREASING INCIDENCE OF CHILDHOOD CANCERS. MATERIALS AND METHODS: A TOTAL OF 131 FATHERS OF CHILDREN WITH RB (NON-FAMILIAL SPORADIC HERITABLE) AND 50 CONTROLS (FATHERS OF HEALTHY CHILDREN) WERE RECRUITED AT A TERTIARY CENTER IN INDIA. SPERM PARAMETERS AS PER WHO 2010 GUIDELINES AND REACTIVE OXYGEN SPECIES (ROS), DNA FRAGMENTATION INDEX (DFI), 8-HYDROXY-2'-DEOXY GUANOSINE (8-OHDG) AND TELOMERE LENGTH WERE ESTIMATED AT DAY 0, AND AFTER 3 AND 6 MONTHS OF INTERVENTION. WE ALSO EXAMINED THE COMPLIANCE WITH YOGA AND MEDITATION PRACTICE AND SMOKING STATUS AT EACH FOLLOW-UP. RESULTS: THE SEMINAL MEAN ROS LEVELS (P<0.05), SPERM DFI (P<0.001), 8-OHDG (P<0.01) LEVELS WERE SIGNIFICANTLY HIGHER IN FATHERS OF CHILDREN WITH RB, AS COMPARED TO CONTROLS AND THE RELATIVE MEAN TELOMERE LENGTH IN THE SPERM WAS SHORTER. LEVELS OF ROS WERE SIGNIFICANTLY REDUCED IN TOBACCO USERS (P<0.05) AS WELL AS IN ALCOHOLICS (P<0.05) AFTER INTERVENTION. DFI REDUCED SIGNIFICANTLY (P<0.05) AFTER 6 MONTHS OF YOGA AND MEDITATION PRACTICE IN ALL GROUPS. THE LEVELS OF OXIDATIVE DNA DAMAGE MARKER 8-OHDG WERE REDUCED SIGNIFICANTLY AFTER 3 MONTHS (P<0.05) AND 6 MONTHS (P<0.05) OF PRACTICE. CONCLUSIONS: OUR RESULTS SUGGEST THAT OS AND ODD DNA MAY CONTRIBUTE TO THE DEVELOPMENT OF CHILDHOOD CANCER. THIS MAY BE DUE TO ACCUMULATION OF OXIDIZED MUTAGENIC BASE 8OHDG , AND ELEVATED MDA LEVELS WHICH RESULTS IN MDA DIMERS WHICH ARE ALSO MUTAGENIC, ABERRANT METHYLATION PATTERN, ALTERED GENE EXPRESSION WHICH AFFECT CELL PROLIFERATION AND SURVIVAL THROUGH ACTIVATION OF TRANSCRIPTION FACTORS. INCREASED MT DNA MUTATIONS AND ABERRANT REPAIR OF MT AND NUCLEAR DNA DUE TO HIGHLY TRUNCATRED DNA REPAIR MECHANISMS ALL CONTRIBUTE TO SPERM GENOME HYPERMUTABILITY AND PERSISTANT OXIDATIVE DNA DAMAGE. OXIDATIVE STRESS IS ALSO ASSOCIATED WITH GENOME WIDE HYPOMETHYLATION, TELOMERE SHORTENING AND MITOCHONDRIAL DYSFUNCTION LEADING TO GENOME HYPERMUTABILITY AND INSTABILITY. TO THE BEST OF OUR KNOWLEDGE, THIS IS THE FIRST STUDY TO REPORT DECLINE IN OS AND ODD AND IMPROVEMENT IN SPERM DNA INTEGRITY FOLLOWING ADOPTION OF MEDITATION AND YOGA BASED LIFE STYLE MODIFICATION.THIS MAY REDUCE DISEASE BURDEN IN NEXT GENERATION AND REDUCE INCIDENCE OF CHILDHOOD CANCERS.	2016	

3  692  42 EFFECT OF COMMUNITY-BASED YOGA INTERVENTION ON OXIDATIVE STRESS AND GLYCEMIC PARAMETERS IN PREDIABETES: A RANDOMIZED CONTROLLED TRIAL. OBJECTIVES: TO STUDY THE EFFECTIVENESS OF YOGA INTERVENTION ON OXIDATIVE STRESS, GLYCEMIC STATUS, BLOOD PRESSURE AND ANTHROPOMETRY IN PREDIABETES. DESIGN: RANDOMIZED-CONTROLLED TRIAL. PARTICIPANTS: TWENTY NINE PREDIABETES SUBJECTS AGED 30-75 YEARS. SETTING: YOGA WAS CONDUCTED AT 4 DIFFERENT COMMUNITY DIABETES CLINICS IN MANGALORE, INDIA. INTERVENTIONS: PARTICIPANTS WERE RANDOMIZED TO EITHER 3-MONTH YOGA OR WAIT-LIST CONTROL GROUPS. MAIN OUTCOME MEASURES: MALONDIALDEHYDE, GLUTATHIONE, VITAMIN C, VITAMIN E, SUPEROXIDE DISMUTASE, PLASMA GLUCOSE, GLYCATED HAEMOGLOBIN, BMI, WAIST CIRCUMFERENCE, WAIST-TO-HIP RATIO AND BLOOD PRESSURE. RESULTS: YOGA INTERVENTION RESULTED IN A SIGNIFICANT DECLINE IN MALONDIALDEHYDE (P<0.001), RELATIVE TO THE CONTROL GROUP. IN COMPARISON WITH THE CONTROL, THERE WAS A SIGNIFICANT IMPROVEMENT IN BMI, WAIST CIRCUMFERENCE, SYSTOLIC BLOOD PRESSURE AND FASTING GLUCOSE LEVELS AT FOLLOW-UP. NO SIGNIFICANT IMPROVEMENT IN GLYCATED HAEMOGLOBIN, WAIST-TO-HIP RATIO OR ANY OF THE ANTIOXIDANTS WAS OBSERVED. CONCLUSIONS: YOGA INTERVENTION MAY BE HELPFUL IN CONTROL OF OXIDATIVE STRESS IN PREDIABETES SUBJECTS. YOGA CAN ALSO BE BENEFICIAL IN REDUCTION IN BMI, WAIST CIRCUMFERENCE, SYSTOLIC BLOOD PRESSURE AND FASTING GLUCOSE. EFFECT OF YOGA ON ANTIOXIDANT PARAMETERS WAS NOT EVIDENT IN THIS STUDY. THE FINDINGS OF THIS STUDY NEED TO BE CONFIRMED IN LARGER TRIALS INVOLVING ACTIVE CONTROL GROUPS.	2013	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
4 1426  43 IMPROVEMENT OF GLUTATHIONE AND TOTAL ANTIOXIDANT STATUS WITH YOGA. OBJECTIVE: SEVERAL STUDIES SUGGEST THAT YOGA CAN DECREASE OXIDATIVE STRESS. HOWEVER REPORTS ARE SCANTY REGARDING WHETHER YOGA TRAINING CAN IMPROVE THE GLUTATHIONE LEVEL OF INDIVIDUAL. THIS STUDY IS DESIGNED TO APPRAISE THE ROLE OF YOGA IN MAINTAINING GLUTATHIONE (REDUCED AND OXIDIZED) LEVELS AND ANTIOXIDANT STATUS. STUDY DESIGN: THIS STUDY WAS CONDUCTED ON HEALTHY MALE VOLUNTEERS FROM THE INDIAN NAVY, WHO WERE DIVIDED INTO TWO GROUPS--A YOGA (N = 30) GROUP AND A CONTROL (N = 21) GROUP. THE YOGA GROUP WAS TRAINED IN YOGA FOR 6 MONTHS. THE YOGA SCHEDULE CONSISTED OF PRAYERS, ASANA, PRANAYAMA, AND MEDITATION. THE CONTROL GROUP PRACTICED ROUTINE PHYSICAL TRAINING EXERCISE FOR 6 MONTHS. BLOOD SAMPLES WERE COLLECTED WHEN THE VOLUNTEERS WERE IN FASTING CONDITION BEFORE AND AFTER COMPLETION OF 6-MONTH TRAINING PERIOD. REDUCED AND OXIDIZED GLUTATHIONE, GLUTATHIONE REDUCTASE ACTIVITY AND TOTAL ANTIOXIDANT STATUS (TAS) WERE ESTIMATED. RESULTS: REDUCED GLUTATHIONE LEVEL INCREASED SIGNIFICANTLY (P < 0.05) IN THE YOGA GROUP AFTER COMPLETION OF TRAINING. GLUTATHIONE REDUCTASE ACTIVITY INCREASED SIGNIFICANTLY IN THE CONTROL GROUP (P < 0.05). TAS INCREASED SIGNIFICANTLY (P < 0.001) IN THE YOGA GROUP AND DECREASED SIGNIFICANTLY (P < 0.001) IN THE CONTROL GROUP. CONCLUSIONS: REGULAR PRACTICE OF YOGA CAN MAINTAIN OR IMPROVE ANTIOXIDANT LEVEL OF THE BODY. THE CLINICAL RELEVANCE IS THAT YOGA PRACTICE CAN BE USED TO MAINTAIN THE ANTIOXIDANT DEFENSE SYSTEM UNDER STRESSFUL CONDITIONS OF TRAINING AS OBSERVED IN THE CASE OF SOLDIERS AND ATHLETES.	2007	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
5  986  30 EFFECTS OF HATHA YOGA EXERCISE ON PLASMA MALONDIALDEHYDE CONCENTRATION AND SUPEROXIDE DISMUTASE ACTIVITY IN FEMALE PATIENTS WITH SHOULDER PAIN. [PURPOSE] THE PURPOSE OF THIS STUDY WAS TO ANALYZE THE EFFECTS OF HATHA YOGA EXERCISE ON PLASMA MALONDIALDEHYDE (MDA) CONCENTRATION AND SUPEROXIDE DISMUTASE (SOD) ACTIVITY IN FEMALE PATIENTS WITH SHOULDER PAIN. [SUBJECTS] SUBJECTS COMPRISED 20 FEMALE PATIENTS WITH SHOULDER PAIN. [METHODS] SUBJECTS WERE DIVIDED INTO 2 GROUPS: A HATHA YOGA EXERCISE GROUP (N = 10) AND A CONTROL GROUP THAT PERFORMED NO EXERCISE (N = 10). THE SUBJECTS' BODY COMPOSITION, PLASMA MALONDIALDEHYDE CONCENTRATIONS, AND SUPEROXIDE DISMUTASE ACTIVITIES WERE MEASURED BEFORE AND AFTER A 16-WEEK HATHA YOGA EXERCISE PROGRAM. [RESULTS] AFTER THE 16-WEEK HATHA YOGA EXERCISE PROGRAM, THE EXERCISE GROUP HAD SIGNIFICANTLY LOWER PLASMA MDA CONCENTRATIONS THAN THE CONTROL GROUP. IN ADDITION, THE EXERCISE GROUP HAD SIGNIFICANTLY HIGHER PLASMA SOD ACTIVITY THAN THE CONTROL GROUP. [CONCLUSIONS] HATHA YOGA EXERCISE IMPROVES FLEXIBILITY, MUSCLE TONE AND STRENGTH, BALANCE, AND JOINT FUNCTION. OUR FINDINGS INDICATE THAT REGULAR AND CONTINUOUS YOGA EXERCISE EFFECTIVELY IMPROVED BODY COMPOSITION, DECREASE PLASMA MDA CONCENTRATION, AND INCREASE PLASMA SOD ACTIVITY IN FEMALE PATIENTS WITH SHOULDER PAIN.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
6 1392  24 IMPACT OF YOGA AND MEDITATION ON CELLULAR AGING IN APPARENTLY HEALTHY INDIVIDUALS: A PROSPECTIVE, OPEN-LABEL SINGLE-ARM EXPLORATORY STUDY. THIS STUDY WAS DESIGNED TO EXPLORE THE IMPACT OF YOGA AND MEDITATION BASED LIFESTYLE INTERVENTION (YMLI) ON CELLULAR AGING IN APPARENTLY HEALTHY INDIVIDUALS. DURING THIS 12-WEEK PROSPECTIVE, OPEN-LABEL, SINGLE ARM EXPLORATORY STUDY, 96 APPARENTLY HEALTHY INDIVIDUALS WERE ENROLLED TO RECEIVE YMLI. THE PRIMARY ENDPOINTS WERE ASSESSMENT OF THE CHANGE IN LEVELS OF CARDINAL BIOMARKERS OF CELLULAR AGING IN BLOOD FROM BASELINE TO WEEK 12, WHICH INCLUDED DNA DAMAGE MARKER 8-HYDROXY-2'-DEOXYGUANOSINE (8-OH2DG), OXIDATIVE STRESS MARKERS REACTIVE OXYGEN SPECIES (ROS), AND TOTAL ANTIOXIDANT CAPACITY (TAC), AND TELOMERE ATTRITION MARKERS TELOMERE LENGTH AND TELOMERASE ACTIVITY. THE SECONDARY ENDPOINTS WERE ASSESSMENT OF METABOTROPHIC BLOOD BIOMARKERS ASSOCIATED WITH CELLULAR AGING, WHICH INCLUDED CORTISOL, BETA-ENDORPHIN, IL-6, BDNF, AND SIRTUIN-1. AFTER 12 WEEKS OF YMLI, THERE WERE SIGNIFICANT IMPROVEMENTS IN BOTH THE CARDINAL BIOMARKERS OF CELLULAR AGING AND THE METABOTROPHIC BIOMARKERS INFLUENCING CELLULAR AGING COMPARED TO BASELINE VALUES. THE MEAN LEVELS OF 8-OH2DG, ROS, CORTISOL, AND IL-6 WERE SIGNIFICANTLY LOWER AND MEAN LEVELS OF TAC, TELOMERASE ACTIVITY, BETA-ENDORPHIN, BDNF, AND SIRTUIN-1 WERE SIGNIFICANTLY INCREASED (ALL VALUES P < 0.05) POST-YMLI. THE MEAN LEVEL OF TELOMERE LENGTH WAS INCREASED BUT THE FINDING WAS NOT SIGNIFICANT (P = 0.069). YMLI SIGNIFICANTLY REDUCED THE RATE OF CELLULAR AGING IN APPARENTLY HEALTHY POPULATION.	2017	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
7 1889  43 REGULAR YOGA PRACTICE IMPROVES ANTIOXIDANT STATUS, IMMUNE FUNCTION, AND STRESS HORMONE RELEASES IN YOUNG HEALTHY PEOPLE: A RANDOMIZED, DOUBLE-BLIND, CONTROLLED PILOT STUDY. OBJECTIVE: THE AIM OF THE PRESENT STUDY IS TO HIGHLIGHT THE BENEFICIAL EFFECTS OF YOGA PRACTICE ON BIO-PARAMETERS, SUCH AS OXIDATIVE STRESS, ANTIOXIDANT COMPONENTS, IMMUNE FUNCTIONS, AND SECRETION OF STRESS HORMONES, IN HEALTHY YOUNG PEOPLE. STUDY DESIGN: THIS STUDY WAS CONDUCTED ON HEALTHY VOLUNTEERS RECRUITED FROM AMONG UNIVERSITY STUDENTS, WHO WERE DIVIDED INTO TWO GROUPS: A CONTROL (NO YOGA INTERVENTION, N=13) GROUP AND A YOGA (N=12) GROUP. YOGA PRACTICE WAS WITH AN INSTRUCTOR FOR 90 MINUTES ONCE A WEEK SPREAD OVER 12 WEEKS, WITH RECOMMENDATIONS TO PRACTICE DAILY AT HOME FOR 40 MINUTES WITH THE HELP OF A DVD. THE YOGA PROGRAM CONSISTED OF YOGA BODY POSES (ASANAS), EXERCISES INVOLVING AWARENESS, VOLUNTARY REGULATION OF BREATH (PRANAYAMA), AND MEDITATIONAL PRACTICES. WHOLE BLOOD SAMPLES WERE COLLECTED WHEN THE VOLUNTEERS HAD FASTED FOR 8 HOURS AT 0 AND 12 WEEKS. THE OXIDATIVE STRESS/ANTIOXIDANT COMPONENTS, IMMUNE-RELATED CYTOKINES, AND STRESS HORMONES WERE EVALUATED IN SERUM OR PLASMA. RESULTS: SERUM LEVELS OF NITRIC OXIDE, F2-ISOPROSTANE, AND LIPID PEROXIDE WERE SIGNIFICANTLY DECREASED BY YOGA PRACTICE (P<0.05 OR P=0.01), WHEREAS SERUM TOTAL GLUTATHIONE (GSH) CONTENTS, ACTIVITIES OF GSH-PEROXIDASE, AND GSH-S-TRANSFERASE WERE REMARKABLY INCREASED AFTER YOGA PRACTICE COMPARED WITH THE CONTROL GROUP (P<0.05 OR P=0.01). YOGA PRACTICE ALSO SIGNIFICANTLY INCREASED IMMUNE-RELATED CYTOKINES, SUCH AS INTERLEUKIN-12, AND INTERFERON-GAMMA, IN SERUM (P<0.05 OR P=0.01). YOGA PRACTICE SIGNIFICANTLY REDUCED THE PLASMA LEVELS OF ADRENALIN (P<0.05) AND INCREASED PLASMA LEVELS OF SEROTONIN COMPARED WITH THE CONTROL GROUP (P<0.05). CONCLUSIONS: REGULAR YOGA PRACTICE REMARKABLY ATTENUATED OXIDATIVE STRESS AND IMPROVED ANTIOXIDANT LEVELS OF THE BODY. MOREOVER, YOGA BENEFICIALLY AFFECTED STRESS HORMONE RELEASES AS WELL AS PARTIALLY IMPROVED IMMUNE FUNCTION.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
8  359  34 ASSOCIATION OF LEUKOCYTE TELOMERE LENGTH WITH OXIDATIVE STRESS IN YOGA PRACTITIONERS. OBJECTIVE: YOGA IS A MIND-BODY MODULATION TECHNIQUE THAT HAS BEEN SHOWN TO HAVE BENEFICIAL EFFECTS ON VARIOUS DISEASES RELATED TO VARIOUS SYSTEMS IN THE BODY. HOWEVER, THE MOLECULAR BASIS OF MECHANISM OF ACTION IS NOT CLEAR. HENCE, THIS STUDY WAS DESIGNED TO STUDY THE LEUKOCYTE TELOMERE BIOLOGY AND ITS RELATION WITH HOMOCYSTEINE AND OXIDATIVE STRESS IN YOGA PRACTITIONERS. MATERIALS AND METHODS: THIS IS A PROSPECTIVE CASE-CONTROL STUDY INVOLVING YOGA PRACTITIONERS AGED 30-40 Y WITH MINIMUM OF TWO YEARS YOGA PRACTICE (YOGA GROUP) AND AGE, GENDER AND BODY MASS INDEX MATCHED SEDENTARY HEALTHY GENERAL POPULATION WITH NO MEDICAL PROBLEMS (CONTROL GROUP). LEUKOCYTE TELOMERE LENGTH (LTL) WAS MEASURED BY USING QUANTITATIVE PCR (QPCR), FASTING PLASMA HOMOCYSTEINE WAS MEASURED BY A RAPID HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY ASSAY AND THE OXIDATIVE STRESS WAS ASSESSED WITH TOTAL ANTIOXIDANT STATUS (TAOS), MALONDIALDEHYDE (MDA) MEASURED BY CALORIMETRY. RESULTS: THE LTL WAS SHORTER IN CONTROL GROUP THAN IN YOGA GROUP (P<0.001). THE TAOS WAS MORE IN YOGA GROUP WHEN COMPARED TO CONTROL GROUP (P=0.008), MDA AND HOMOCYSTEINE WAS HIGH IN CONTROL GROUP WHEN COMPARED TO YOGA GROUP (P<0.001). FURTHER, THE LTL WAS POSITIVELY CORRELATED WITH TAOS (R=0.841, P<0.001) AND NEGATIVELY CORRELATED WITH MDA (R=-0.931, P<0.001) AND HOMOCYSTEINE (R=-0.756, P<0.001). CONCLUSION: THE LTL IS WELL-PRESERVED IN PEOPLE WHO PRACTICE YOGA REGULARLY WITH LOWER SYSTEMIC OXIDATIVE STRESS COMPARED TO THOSE WHO HAVE A RELATIVELY SEDENTARY LIFESTYLE DESPITE LACK OF ANY MEDICAL DISORDERS. THE HABITUAL YOGA PRACTICE SEEMS TO INHIBIT REPLICATIVE CELLULAR SENESCENCE.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
9  276  42 ADDITIONAL IMPROVEMENT OF RESPIRATORY TECHNIQUE ON VASCULAR FUNCTION IN HYPERTENSIVE POSTMENOPAUSAL WOMEN FOLLOWING YOGA OR STRETCHING VIDEO CLASSES: THE YOGINI STUDY. BACKGROUND: HYPERTENSION REMAINS HIGHLY PREVALENT IN POSTMENOPAUSAL WOMEN, ALONG WITH VASCULAR DYSFUNCTION AND INCREASED OXIDATIVE STRESS. IN SUCH CONTEXT, REGULAR EXERCISES, YOGA PRACTICE, AND SLOW BREATHING HAVE BEEN RECOMMENDED TO TREAT HYPERTENSION. HOWEVER, THE EFFECTS OF THE MULTIPLE COMPONENTS OF YOGA, INCLUDING THE RESPIRATORY TECHNIQUES INVOLVED IN THE PRACTICE, ON HYPERTENSION AND ON VASCULAR AND ENDOTHELIAL FUNCTION HAVE NEVER BEEN EVALUATED. OBJECTIVE: THIS STUDY AIMED TO INVESTIGATE THE ADDITIONAL EFFECTS OF RESPIRATORY TECHNIQUE ON VASCULAR FUNCTION AND OXIDATIVE STRESS PROFILE IN HYPERTENSIVE POSTMENOPAUSAL WOMEN (HPMWS) FOLLOWING YOGA OR STRETCHING VIDEO CLASSES. STUDY DESIGN: HYPERTENSIVE POSTMENOPAUSAL WOMEN WERE RECRUITED AND RANDOMIZED FOR 12 WEEKS, TWICE A WEEK, OF SUPERVISED YOGA OR STRETCHING VIDEO CLASSES OF 75 MIN FOR 12 WEEKS ASSOCIATED OR NOT WITH RESPIRATORY TECHNIQUE. BASELINE AND POST-INTERVENTION MEASUREMENTS INCLUDED PULSE WAVE VELOCITY (PWV), FLOW-MEDIATED DILATION (FMD), AND OXIDATIVE STRESS PARAMETERS. HYPERTENSIVE POSTMENOPAUSAL WOMEN (59 +/- 0.7 YEARS) WHO ENDED THE PROTOCOL WERE DISTRIBUTED INTO THREE GROUPS: (1) CONTROL GROUP (YOGA OR STRETCHING, C, N = 14); (2) YOGA + RESPIRATORY TECHNIQUE (Y+, N = 10); (3) STRETCHING + RESPIRATORY TECHNIQUE (S+, N = 9). RESULTS: DIASTOLIC BLOOD PRESSURE AND FMD [BASELINE: C: 6.94 +/- 1.97%, Y+: 7.05 +/- 1.65%, AND S+: 3.54 +/- 2.01% VS. POST: C: 16.59 +/- 3.46% (P = 0.006), Y+: 13.72 +/- 2.81% (P = 0.005), AND S+: 11.79 +/- 0.99% (P = 0.0001)] HAVE SIGNIFICANTLY INCREASED IN ALL GROUPS WHEN BASELINE AND POST-PRACTICE VALUES WERE COMPARED. HOWEVER, RESTING HEART RATE AND PWV [BASELINE: Y+: 10.44 +/- 3.69 AND S+: 9.50 +/- 0.53 M/S VS. POST: Y+: 9.45 +/- 0.39 (P = 0.003) AND S+: 8.02 +/- 0.47 M/S (P = 0.003)] DECREASED SIGNIFICANTLY ONLY IN THE Y+ AND S+ GROUPS (BASELINE VS. POST). SYSTEMIC ANTIOXIDANT ENZYME ACTIVITIES (SUPEROXIDE DISMUTASE AND CATALASE) INCREASED IN ALL GROUPS, AND HYDROGEN PEROXIDE AND LIPOPEROXIDATION REDUCED IN Y+ AND S+ (BASELINE VS. POST). CONCLUSIONS: TWELVE WEEKS OF YOGA OR STRETCHING VIDEO CLASSES PROMOTED POSITIVE CHANGES IN SEVERAL OUTCOMES GENERALLY REGARDED AS CARDIOVASCULAR RISK FACTORS IN HPMWS, AND THESE CHANGES WERE EVEN MORE PRONOUNCED BY THE ASSOCIATION WITH RESPIRATORY TECHNIQUE.	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
10 1104  33 EFFECTS OF YOGA VERSUS SHAM YOGA ON OXIDATIVE STRESS, GLYCEMIC STATUS, AND ANTHROPOMETRY IN TYPE 2 DIABETES MELLITUS: A SINGLE-BLINDED RANDOMIZED PILOT STUDY. STUDIES HAVE SHOWN A BENEFICIAL ROLE OF YOGA IN TRE A T I N G TYPE 2 DIABETES MELLITUS. THE PRESENT STUDY PROCEEDS IN THE FIELD BY PROVIDING AN ACTIVE CONTROL. WE AIMED TO EVALUATE THE EFFECT OF 3 MONTHS OF YOGA ON OXIDATIVE STRESS, GLYCEMIC STATUS, AND ANTHROPOMETRY IN TYPE 2 DIABETES MELLITUS. FORTY PARTICIPANTS WERE RANDOMIZED TO RECEIVE EITHER YOGA (N = 20) OR SHAM YOGA (N = 20) AS A CONTROL. YOGA INCLUDED POSTURES AND BREATHING EXERCISES, AND NONAEROBIC STRETCHING EXERCISE COMPRISED THE CONTROL. SIGNIFICANT WITHIN-GROUP DIFFERENCES IN MALONDIALDEHYDE, VITAMIN C, SUPEROXIDE DISMUTASE, FASTING BLOOD GLUCOSE, GLYCOSYLATED HEMOGLOBIN, BODY MASS INDEX, WAIST CIRCUMFERENCE, AND BLOOD PRESSURE WERE EVIDENT IN BOTH GROUPS. YOGA PARTICIPANTS HAD SIGNIFICANTLY GREATER IMPROVEMENT IN REDUCED GLUTATHIONE COMPARED TO CONTROLS. NO SIGNIFICANT DIFFERENCES BETWEEN GROUPS WERE OBSERVED IN ANY OTHER OUTCOME VARIABLES. YOGA AND SHAM YOGA HAD IDENTICAL EFFECTS ON OXIDATIVE STRESS, GLYCEMIC STATUS, AND ANTHROPOMETRY IN TYPE 2 DIABETES MELLITUS. LEVELS OF REDUCED GLUTATHIONE IMPROVED ONLY IN THE YOGA GROUP. THIS RESEARCH NEEDS TO BE CONFIRMED BY LARGER AND SUFFICIENTLY POWERED STUDIES.	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
11 2290  44 THERAPEUTIC EFFECT OF YOGA IN PATIENTS WITH HYPERTENSION WITH REFERENCE TO GST GENE POLYMORPHISM. BACKGROUND: HYPERTENSION, A CHRONIC MEDICAL CONDITION OF INCREASED BLOOD PRESSURE, IS A SERIOUS PUBLIC HEALTH PROBLEM. ENVIRONMENTAL AND GENETIC RISK FACTORS ARE KNOWN TO PREDISPOSE TO HYPERTENSION. THE PRESENT STUDY WAS DESIGNED TO INVESTIGATE THE ASSOCIATION OF GLUTATHIONE S-TRANSFERASE (GST) GENE POLYMORPHISM WITH OXIDATIVE STRESS IN HYPERTENSIVE PATIENTS AND THE POSSIBLE BENEFICIAL EFFECT OF YOGA ON THEM. MATERIALS AND METHODS: SIXTY (60) HYPERTENSIVE INDIVIDUALS, BETWEEN 30 AND 60 YEARS OF AGE, WERE DIVIDED INTO TWO GROUPS OF 30 EACH. THE YOGA GROUP WAS SUBJECTED TO 50-60 MINUTES OF YOGIC PRACTICES DAILY FOR 42 DAYS, WHILE THE CONTROL GROUP INCLUDED THE REMAINING 30 AGE- AND SEX-MATCHED HYPERTENSIVE INDIVIDUALS. GST GENE POLYMORPHISM WAS ANALYZED USING MULTIPLE ALLELE SPECIFIC POLYMERASE CHAIN REACTION, AND OXIDATIVE STRESS PARAMETERS WERE ASSESSED BIOCHEMICALLY. RESULTS: ASSESSMENT OF BLOOD PRESSURE SHOWED A STATISTICALLY SIGNIFICANT THOUGH MODEST REDUCTION (P<0.05) IN THE YOGA GROUP AS COMPARED TO THE CONTROL GROUP. MALONDIALDEHYDE WAS OBSERVED TO BE SIGNIFICANTLY LOW (P<0.05), WHILE ANTIOXIDANT CAPACITY IN THE FORM OF GST SHOWED AN INCREASING TREND AND FERRIC-REDUCING ABILITY OF PLASMA WAS SIGNIFICANTLY INCREASED (P<0.05) IN THE SUBJECTS WHO PRACTICED YOGA. CONCLUSIONS: IN CONCLUSION, YOGA HAS BEEN FOUND TO DECREASE BLOOD PRESSURE AS WELL AS THE LEVELS OF OXIDATIVE STRESS IN PATIENTS WITH HYPERTENSION.	2013	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
12  508  36 COMPARATIVE EFFICACY OF A 12 WEEK YOGA-BASED LIFESTYLE INTERVENTION AND DIETARY INTERVENTION ON ADIPOKINES, INFLAMMATION, AND OXIDATIVE STRESS IN ADULTS WITH METABOLIC SYNDROME: A RANDOMIZED CONTROLLED TRIAL. THE PRESENT RANDOMIZED CONTROLLED TRIAL (RCT) EVALUATED THE COMPARATIVE EFFICACY OF 12 WEEK YOGA-BASED LIFESTYLE INTERVENTION (YBLI) AND DIETARY INTERVENTION (DI) ALONE ON ADIPOKINES, INFLAMMATION, AND OXIDATIVE STRESS IN INDIAN ADULTS WITH METABOLIC SYNDROME (MET S). A PARALLEL, TWO ARM, RCT WAS CONDUCTED IN INTEGRAL HEALTH CLINIC (IHC), ALL INDIA INSTITUTE OF MEDICAL SCIENCES, INDIA FROM 2012 TO 2014. IHC IS AN OUTPATIENT FACILITY CONDUCTING YBLI PROGRAMS FOR PREVENTION AND MANAGEMENT OF CHRONIC DISEASES. TWO HUNDRED SIXTY MEN AND WOMEN (20-45 YEARS) VISITING THE OUTPATIENT DEPARTMENT OF A TERTIARY CARE HOSPITAL WERE DIAGNOSED WITH MET S AND RANDOMIZED 1:1 TO RECEIVE 12 WEEK YBLI (N = 130) OR DI (N = 130). PRIMARY OUTCOMES WERE CHANGE IN PLASMA LEVELS OF ADIPOKINES (LEPTIN, ADIPONECTIN, AND LEPTIN:ADIPONECTIN RATIO), MARKERS OF INFLAMMATION (TUMOR NECROSIS FACTOR [TNF]-ALPHA, INTERLEUKIN [IL]-6), MARKERS OF OXIDATIVE STRESS (THIOBARBITURIC ACID REACTIVE SUBSTANCES [TBARS], 8-HYDROXY-2'-DEOXYGUANOSINE [8-OHDG], AND SUPEROXIDE DISMUTASE [SOD]) MEASURED AT BASELINE, 2 WEEKS, AND 12 WEEKS. YBLI GROUP SHOWED A SIGNIFICANT DECREASE IN LEPTIN, LEPTIN:ADIPONECTIN RATIO, IL-6, 8-OHDG, AND TBARS LEVELS, WHEREAS THERE WAS A SIGNIFICANT INCREASE IN ADIPONECTIN AND SOD LEVELS. NO SIGNIFICANT CHANGES WERE NOTICED IN DI ALONE GROUP. YBLI SHOWED SIGNIFICANTLY GREATER REDUCTION IN TBARS LEVELS THAN IN DI GROUP, SUGGESTIVE OF REDUCED OXIDATIVE STRESS IN ADULTS WITH MET S. A 12 WEEK YBLI HAD A POSITIVE IMPACT ON OXIDATIVE STRESS VERSUS DI ALONE IN ADULTS WITH MET S.	2019	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
13  662  42 EFFECT OF 3-MONTH YOGA ON OXIDATIVE STRESS IN TYPE 2 DIABETES WITH OR WITHOUT COMPLICATIONS: A CONTROLLED CLINICAL TRIAL. OBJECTIVE: TO ASSESS THE EFFECT OF YOGA ON ANTHROPOMETRY, BLOOD PRESSURE, GLYCEMIC CONTROL, AND OXIDATIVE STRESS IN TYPE 2 DIABETIC PATIENTS ON STANDARD CARE IN COMPARISON WITH STANDARD CARE ALONE. RESEARCH DESIGN AND METHODS: THE STUDY INVOLVED 123 PATIENTS STRATIFIED ACCORDING TO GROUPS WITH MICROVASCULAR COMPLICATIONS, MACROVASCULAR COMPLICATIONS, AND PERIPHERAL NEUROPATHY AND WITHOUT COMPLICATIONS AND ASSIGNED TO RECEIVE EITHER STANDARD CARE OR STANDARD CARE ALONG WITH ADDITIONAL YOGA FOR 3 MONTHS. RESULTS: IN COMPARISON WITH STANDARD CARE ALONE, YOGA RESULTED IN SIGNIFICANT REDUCTION IN BMI, GLYCEMIC CONTROL, AND MALONDIALDEHYDE AND INCREASE IN GLUTATHIONE AND VITAMIN C. THERE WERE NO DIFFERENCES IN WAIST CIRCUMFERENCE, WAIST-TO-HIP RATIO, BLOOD PRESSURE, VITAMIN E, OR SUPEROXIDE DISMUTASE IN THE YOGA GROUP AT FOLLOW-UP. CONCLUSIONS: YOGA CAN BE USED AS AN EFFECTIVE THERAPY IN REDUCING OXIDATIVE STRESS IN TYPE 2 DIABETES. YOGA IN ADDITION TO STANDARD CARE HELPS REDUCE BMI AND IMPROVE GLYCEMIC CONTROL IN TYPE 2 DIABETIC PATIENTS.	2011	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
14 2652  34 YOGA IMPROVES MITOCHONDRIAL HEALTH AND REDUCES SEVERITY OF AUTOIMMUNE INFLAMMATORY ARTHRITIS: A RANDOMIZED CONTROLLED TRIAL. BACKGROUND: OXIDATIVE STRESS (OS) AND MITOCHONDRIAL ALTERATIONS HAVE BEEN IMPLICATED IN THE PATHOGENESIS OF RHEUMATOID ARTHRITIS (RA). VARIOUS ENVIRONMENTAL TRIGGERS LIKE AIR POLLUTANTS, SMOKING, UNHEALTHY SOCIAL HABITS AND SEDENTARY LIFESTYLE INDUCE OS, WHICH MAY COMPROMISE MITOCHONDRIAL INTEGRITY. THIS TRIAL WAS DESIGNED TO EXPLORE THE EFFECT OF 8-WEEKS YOGA PRACTICE ON MITOCHONDRIAL HEALTH AND DISEASE SEVERITY IN AN ACTIVE RA GROUP COMPARED WITH A USUAL-CARE CONTROL GROUP. METHODS: A TOTAL OF 70 SUBJECTS WERE RANDOMIZED INTO TWO GROUPS: YOGA GROUP AND NON-YOGA GROUP. MITOCHONDRIAL HEALTH WAS ASSESSED BY CALCULATION OF MITOCHONDRIAL DNA COPY NUMBER (MTDNA-CN), OS MARKERS, MITOCHONDRIAL ACTIVITY, MITOCHONDRIAL MEMBRANE POTENTIAL (DELTAPSIM), CIRCADIAN RHYTHM MARKERS AND TRANSCRIPTS ASSOCIATED WITH MITOCHONDRIAL INTEGRITY: AMPK, TIMP-1, KLOTHO, SIRT-1, AND TFAM. PARAMETERS OF DISEASE ACTIVITY AND DISABILITY QUOTIENT WERE ALSO ASSESSED BY DISEASE ACTIVITY SCORE - ERYTHROCYTE SEDIMENTATION RATE (DAS28-ESR) AND HEALTH ASSESSMENT QUESTIONNAIRE-DISABILITY INDEX (HAQ-DI), RESPECTIVELY. RESULTS: IN YOGA GROUP, THERE WAS A SIGNIFICANT UPREGULATION OF MTDNA-CN, MITOCHONDRIAL ACTIVITY MARKERS, DELTAPSIM, AND TRANSCRIPTS THAT MAINTAIN MITOCHONDRIAL INTEGRITY AFTER 8-WEEKS OF YOGA. THERE WAS OPTIMIZATION OF OS MARKERS, AND CIRCADIAN RHYTHM MARKERS POST 8-WEEKS PRACTICE OF YOGA. YOGA GROUP PARTICIPANTS SHOWED SIGNIFICANT IMPROVEMENTS IN DAS28-ESR (P < 0.05) AND HAQ-DI (P < 0.05) OVER THE NON-YOGA GROUP. CONCLUSION: ADOPTION OF YOGA BY RA PATIENTS HOLDS THE KEY TO ENHANCE MITOCHONDRIAL HEALTH, IMPROVE CIRCADIAN RHYTHM MARKERS, OS MARKER REGULATION, UPREGULATION OF TRANSCRIPTS THAT MAINTAIN MITOCHONDRIAL INTEGRITY, REDUCE DISEASE ACTIVITY AND ITS ASSOCIATED CONSEQUENCES ON HEALTH OUTCOME AND HENCE CAN BE BENEFICIAL AS AN ADJUNCT THERAPY.	2021	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
15 2153  30 THE EFFECTS OF SUDARSHAN KRIYA YOGA ON SOME PHYSIOLOGICAL AND BIOCHEMICAL PARAMETERS IN MILD HYPERTENSIVE PATIENTS. AN OPEN LABEL INTERVENTION STUDY WAS UNDERTAKEN ON 26 MILD HYPERTENSIVES AND 26 APPARENTLY HEALTHY ADULTS (30-60 Y), FOR THE EFFECT OF SUDARSHAN KRIYA YOGA PRACTICE FOR TWO MONTHS AS COMPLEMENTARY THERAPY. IN THE HYPERTENSIVES, THERE WAS A SIGNIFICANT DECREASE IN DIASTOLIC BLOOD PRESSURE (P < 0.01), SERUM UREA (P < 0.01) AND PLASMA MDA (MALONDIALDEHYDE ADDUCTS) AS OXIDATIVE STRESS MARKER (P < 0.05). OTHER PARAMETERS; VIZ.; PLASMA LEVELS OF CHOLESTEROL, TRIGLYCERIDES, GLUCOSE, DID NOT CHANGE SIGNIFICANTLY (P > 0.1). THE PATTERN OF CHANGE IN MOST OF THE STUDY PARAMETERS WAS SUCH THAT VALUES ABOVE NORMAL RANGE WERE LOWERED BUT VALUES WITHIN NORMAL RANGE WERE UNALTERED. THE ACTION OF YOGA ON DIASTOLIC BLOOD PRESSURE, MALONDIALDEHYDE ADDUCTS AND KIDNEY FUNCTION IN HYPERTENSIVES WAS OF COUNTERACTIVE NATURE AND FELT TO BE DISTINCTLY DIFFERENT THAN THE EFFECT OF DRUGS.	2011	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
16 1917  36 ROLE OF YOGA AND ITS PLAUSIBLE MECHANISM IN THE MITIGATION OF DNA DAMAGE IN TYPE-2 DIABETES: A RANDOMIZED CLINICAL TRIAL. BACKGROUND: ALTHOUGH YOGA IS FOUND TO BE BENEFICIAL IN THE MANAGEMENT OF TYPE 2 DIABETES (T2D), ITS MECHANISM OF ACTION IS POORLY UNDERSTOOD. T2D IS ALSO KNOWN TO BE ASSOCIATED WITH INCREASED OXIDATIVE STRESS (OS) AND DNA DAMAGE. PURPOSE: THIS STUDY EXAMINES HOW YOGA MODULATES OS-INDUCED DNA DAMAGE AND THE EFFICIENCY OF DNA REPAIR IN T2D CONDITIONS. METHODS: IN THIS ASSESSOR-MASKED RANDOMIZED CLINICAL TRIAL, T2D SUBJECTS (N = 61), AGED (MEAN +/- SD, 50.3 +/- 4.2) WERE RANDOMLY ALLOCATED INTO YOGA GROUP (31) THAT RECEIVED 10 WEEKS OF YOGA INTERVENTION AND CONTROL (30) WITH ROUTINE EXERCISES. MOLECULAR AND BIOCHEMICAL ASSESSMENTS WERE DONE BEFORE AND AFTER THE INTERVENTION PERIOD. STRUCTURAL EQUATION MODELING USING "R" WAS USED FOR MEDIATION ANALYSIS. RESULTS: AT THE END OF THE 10TH WEEK, YOGA GROUP SHOWED SIGNIFICANT REDUCTION IN DNA DAMAGE INDICATORS LIKE TAIL MOMENT (-5.88[95%CI: -10.47 TO -1.30]; P = .013) AND OLIVE TAIL MOMENT (-2.93[95%CI: -4.87 TO -1.00]; P < .01), OXIDATIVE DNA DAMAGE MARKER 8-OHDG (-60.39[95%CI: -92.55 TO -28.23]; P < .001) AND FASTING BLOOD SUGAR (-22.58[95%CI: -44.33 TO -0.83]; P = .042) COMPARED TO CONTROL. OGG1 PROTEIN EXPRESSION INDICATING DNA REPAIR, IMPROVED SIGNIFICANTLY (17.55[95%CI:1.37 TO 33.73]; P = .034) WHEREAS TOTAL ANTIOXIDANT CAPACITY DID NOT (5.80[95%CI: -0.86 TO 12.47]; P = 0.086). MEDIATION ANALYSIS INDICATED THAT IMPROVEMENTS IN OXIDATIVE DNA DAMAGE AND DNA REPAIR TOGETHER PLAYED A MAJOR MEDIATORY ROLE (97.4%) IN CARRYING THE EFFECT OF YOGA. CONCLUSION: THE BENEFICIAL EFFECT OF YOGA ON DNA DAMAGE IN T2D SUBJECTS WAS FOUND TO BE MEDIATED BY MITIGATION OF OXIDATIVE DNA DAMAGE AND ENHANCEMENT OF DNA REPAIR. CLINICAL TRIAL INFORMATION: (WWW.CTRI.NIC.IN) CTRI/2018/07/014825.	2022	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
17 1401  45 IMPACT OF YOGA ON BIOCHEMICAL PROFILE OF ASTHMATICS: A RANDOMIZED CONTROLLED STUDY. BACKGROUND: ASTHMA IS A CHRONIC INFLAMMATORY DISORDER OF THE AIRWAYS. THE CHRONIC INFLAMMATION CAUSES AN ASSOCIATED INCREASE IN AIRWAY HYPERRESPONSIVENESS THAT LEADS TO RECURRENT EPISODES OF WHEEZING, BREATHLESSNESS, CHEST TIGHTNESS, AND COUGHING AT NIGHT OR IN THE EARLY MORNING. MOST OF THE STUDIES HAVE REPORTED, AS THE EFFECTS OF YOGA ON BRONCHIAL ASTHMA, SIGNIFICANT IMPROVEMENTS IN PULMONARY FUNCTIONS, QUALITY OF LIFE, AND DECREASE IN MEDICATION USE, BUT NONE OF THE STUDIES HAS ATTEMPTED TO SHOW THE EFFECT OF YOGA ON BIOCHEMICAL CHANGES. OBJECTIVE: TO EVALUATE THE EFFECT OF YOGA ON BIOCHEMICAL PROFILE OF ASTHMATICS. MATERIALS AND METHODS: IN THE PRESENT STUDY, 276 PATIENTS OF MILD TO MODERATE ASTHMA (FEV 1> 60%) AGED BETWEEN 12 TO 60 YEARS WERE RECRUITED FROM THE DEPARTMENT OF PULMONARY MEDICINE, KING GEORGE'S MEDICAL UNIVERSITY, U.P., LUCKNOW, INDIA. THEY WERE RANDOMLY DIVIDED INTO TWO GROUPS: YOGA GROUP (WITH STANDARD MEDICAL TREATMENT AND YOGIC INTERVENTION) AND CONTROL GROUP AS STANDARD MEDICAL TREATMENT (WITHOUT YOGIC INTERVENTION). AT COMPLETION OF 6 MONTHS OF THE STUDY PERIOD, 35 SUBJECTS WERE DROPPED OUT, SO OUT OF 276 SUBJECTS, ONLY 241 SUBJECTS COMPLETED THE WHOLE STUDY (121 SUBJECTS FROM YOGA GROUP AND 120 SUBJECTS FROM CONTROL GROUP). BIOCHEMICAL ASSESSMENT WAS CARRIED OUT AT BASELINE AND AFTER 6 MONTHS OF THE STUDY PERIOD. RESULTS: IN YOGA GROUP, THERE WAS SIGNIFICANT IMPROVEMENT FOUND IN THE PROPORTION OF HEMOGLOBIN AND ANTIOXIDANT SUPEROXIDE DISMUTASE IN COMPARISON TO CONTROL GROUP AND SIGNIFICANT DECREASE WAS FOUND IN TOTAL LEUKOCYTE COUNT (TLC) AND DIFFERENTIAL LEUKOCYTES COUNT IN COMPARISON TO CONTROL GROUP. THERE WAS NO SIGNIFICANT CHANGE FOUND IN TLC, POLYMORPHS, AND MONOCYTES IN BETWEEN GROUP COMPARISON. CONCLUSIONS: YOGA GROUP GOT SIGNIFICANTLY BETTER IMPROVEMENT IN BIOCHEMICAL VARIABLES THAN CONTROL GROUP. RESULT SHOWS THAT YOGA CAN BE PRACTICED AS ADJUVANT THERAPY WITH STANDARD INHALATION THERAPY FOR BETTER OUTCOME OF ASTHMA.	2014	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
18 1102  44 EFFECTS OF YOGA TRAINING ON BODY COMPOSITION AND OXIDANT-ANTIOXIDANT STATUS AMONG HEALTHY MALE. BACKGROUND: THE STRESSFUL CONDITION MAY CAUSE OXIDATIVE STRESS, WHICH IS RESPONSIBLE FOR VARIOUS DISEASES. AIMS: THE PRESENT STUDY WAS DESIGNED TO FIND OUT WHETHER YOGA HAS IMPACT ON THE REDUCTION OF OXIDATIVE STRESS. METHODS: FOR THE PRESENT STUDY, 95 (N = 95) HEALTHY MALE VOLUNTEERS WITHIN THE AGE GROUP OF 18-24 YEARS WERE INCLUDED, 35 (N = 35) VOLUNTEERS WERE EXCLUDED. THE REMAINING 60 (N = 60) VOLUNTEERS WERE RANDOMLY DIVIDED INTO TWO GROUPS: (A) YOGA GROUP (N = 30) AND (B) CONTROL GROUP (N = 30). YOGA TRAINING WAS GIVEN FOR 60 MIN PER DAY, 6 DAYS PER WEEK FOR 12 WEEKS IN THE YOGA GROUP, WITH NO YOGA TRAINING IN CONTROL GROUP. ASSESSMENT OF BODY COMPOSITION AND OXIDANT-ANTIOXIDANT STATUS WERE PERFORMED IN BOTH THE GROUPS AT BASELINE, BEFORE YOGA TRAINING (0 WEEK) AND AFTER (12 WEEKS) OF THE TRAINING. RESULTS: SIGNIFICANT REDUCTION (P < 0.001) IN THE PERCENTAGE OF BODY FAT AND MALONDIALDEHYDE; SIGNIFICANT ELEVATION (P < 0.001) IN SUPEROXIDE DISMUTASE, CATALASE, REDUCED GLUTATHIONE AND ASCORBIC ACID LEVELS WERE NOTED IN THE YOGA GROUP AFTER 12 WEEKS WHEN COMPARED TO BASELINE DATA (0 WEEK). HOWEVER, THERE WAS NO SIGNIFICANT DIFFERENCE IN HEIGHT, WEIGHT, BODY MASS INDEX, BODY SURFACE AREA AND LEAN BODY MASS AMONG THE YOGA GROUP AFTER 12 WEEKS WHEN COMPARED TO BASELINE DATA. THESE CHANGES MIGHT BE DUE TO YOGA TRAINING. CONCLUSIONS: REGULAR YOGA PRACTICE REDUCES BODY FAT AND OXIDATIVE STRESS. YOGA TRAINING MAY BE HELPFUL TO REDUCE THE CHANCE OF OCCURRENCE OF VARIOUS DISEASES AND HELPS TO MAINTAIN NORMAL HEALTHY LIFESTYLE.	2018	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
19 1374  33 IMPACT OF AN INTEGRATED YOGA THERAPY PROTOCOL ON INSULIN RESISTANCE AND GLYCEMIC CONTROL IN PATIENTS WITH TYPE 2 DIABETES MELLITUS. OBJECTIVE: DIABETES MELLITUS (DM), CHARACTERIZED BY CHRONIC HYPERGLYCEMIA, IS ATTRIBUTED TO RELATIVE INSULIN DEFICIENCY OR RESISTANCE, OR BOTH. STUDIES HAVE SHOWN THAT YOGA CAN MODULATE PARAMETERS OF INSULIN RESISTANCE. THE PRESENT STUDY EXPLORED THE POSSIBLE BENEFICIAL EFFECTS OF INTEGRATED YOGA THERAPY WITH REFERENCE TO GLYCEMIC CONTROL AND INSULIN RESISTANCE (IR) IN INDIVIDUALS WITH DIABETES MAINTAINED ON STANDARD ORAL MEDICAL CARE WITH YOGA THERAPY, COMPARED TO THOSE ON STANDARD ORAL MEDICAL CARE ALONE. METHODS: IN THIS STUDY, THE SUBJECTS ON YOGA INTERVENTION COMPRISED 35 TYPE 2 DIABETICS, AND AN EQUAL NUMBER OF VOLUNTEERS CONSTITUTED THE CONTROL GROUP. SUBJECTS RANGED IN AGE FROM 30 TO 70 YEARS, WITH HEMOGLOBIN A1C (HBA1C) TEST MORE THAN 7%, AND WERE MAINTAINED ON DIABETIC DIET AND ORAL HYPOGLYCEMIC AGENTS. BLOOD SAMPLES WERE DRAWN PRIOR TO AND AFTER 120 DAYS OF INTEGRATED YOGA THERAPY INTERVENTION. FASTING BLOOD GLUCOSE (FBG), POST-PRANDIAL BLOOD GLUCOSE (PPBG), HBA1C, INSULIN, AND LIPID PROFILE WERE ASSESSED IN BOTH THE INTERVENTION AND CONTROL GROUPS. RESULTS: THE INTERVENTION GROUP REVEALED SIGNIFICANT IMPROVEMENTS IN BODY MASS INDEX (BMI) (0.7 KG/M(2) MEDIAN DECREASE; P=0.001), FBG (20 MG/DL MEDIAN DECREASE; P<0.001), PPBG (33 MG/DL MEDIAN DECREASE; P<0.001), HBA1C (0.4% MEDIAN DECREASE; P<0.001), HOMEOSTATIC MODEL ASSESSMENT FOR INSULIN RESISTANCE (HOMA-IR) (1.2 MEDIAN DECREASE; P<0.001), CHOLESTEROL (13 MG/DL MEDIAN DECREASE, P=0.006), TRIACYLGLYCEROL (22 MG/DL MEDIAN DECREASE; P=0.027), LOW-DENSITY LIPOPROTEIN (6 MG/DL MEDIAN DECREASE; P=0.004), AND VERY-LOW-DENSITY LIPOPROTEIN LEVELS (4 MG/DL MEDIAN DECREASE; P=0.032). INCREASES IN HIGH-DENSITY LIPOPROTEIN AFTER 120 DAYS WERE NOT SIGNIFICANT (6 MG/DL MEDIAN INCREASE; P=0.15). HOWEVER, WHEN COMPARED TO CHANGES OBSERVED IN PATIENTS IN THE CONTROL GROUP, ALL THESE IMPROVEMENTS PROVED TO BE SIGNIFICANT. CONCLUSION: ADMINISTRATION OF INTEGRATED YOGA THERAPY TO INDIVIDUALS WITH DIABETES LEADS TO A SIGNIFICANT IMPROVEMENT IN GLYCEMIC CONTROL, INSULIN RESISTANCE, AND KEY BIOCHEMICAL PARAMETERS.	2022	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
20  324  26 ANTHROPOMETRIC, BIOCHEMICAL AND CLINICAL PARAMETERS IN CLIMACTERIC YOGA PRACTITIONERS. OBJECTIVE: THIS STUDY AIMED TO EVALUATE ANTHROPOMETRIC, BIOCHEMICAL AND CLINICAL PARAMETERS IN CLIMACTERIC YOGA PRACTITIONERS. METHODS: THIS STUDY INVESTIGATED 108 CLIMACTERIC WOMEN. WE RECRUITED 28 WOMEN BETWEEN 40 AND 65 YEARS OLD WHO STARTED YOGA PRACTICES IN PREMENOPAUSE AND HAD ALREADY PRACTICED FOR AT LEAST 5 YEARS. AS CONTROLS, WE SELECTED 30 PHYSICAL ACTIVITY (PA) PRACTITIONERS WHO HAD PRACTICED FOR AT LEAST 5 YEARS AND 50 SEDENTARY WOMEN IN THE SAME AGE RANGE. WE CONDUCED ANTHROPOMETRIC, BIOCHEMICAL AND BLOOD PRESSURE MEASUREMENTS. RESULTS: THE YOGA GROUP HAD SIGNIFICANTLY LOWER FASTING BLOOD GLUCOSE THAN THE PA PRACTITIONERS AND SEDENTARY WOMEN. YOGA PRACTITIONERS ALSO HAD LOWER WEIGHT, BODY MASS INDEX, WAIST CIRCUMFERENCE, BODY FAT PERCENTAGE AND WAIST-TO-HEIGHT RATIO; HIGHER LEVELS OF HIGH-DENSITY LIPOPROTEIN CHOLESTEROL; LOWER LEVELS OF TRIGLYCERIDES, INSULIN, HOMEOSTASIS MODEL ASSESSMENT OF INSULIN RESISTANCE, URIC ACID, APOLIPOPROTEIN B AND HIGH-SENSITIVITY C-REACTIVE PROTEIN; AND LOWER FREQUENCY OF METABOLIC SYNDROME, LIPID ACCUMULATION PRODUCT, VISCERAL ADIPOSITY INDEX AND SYSTOLIC BLOOD PRESSURE THAN THE SEDENTARY WOMEN. CONCLUSION: YOGA PRACTITIONERS HAD LOWER GLUCOSE SERUM CONCENTRATIONS THAN THE PA PRACTITIONERS AND SEDENTARY WOMEN. OVERALL, THE YOGA GROUP ALSO HAD BETTER ANTHROPOMETRIC, BIOCHEMICAL AND CLINICAL VARIABLES THAN THE OTHER GROUPS. ALTHOUGH FURTHER INVESTIGATION IS REQUIRED, YOGA PRACTICE IN PREMENOPAUSE SEEMS TO BE BENEFICIAL FOR WOMEN WHEN THEY REACH MENOPAUSE.	2022