1 1989 114 SPERM METHYLOME ALTERATIONS FOLLOWING YOGA-BASED LIFESTYLE INTERVENTION IN PATIENTS OF PRIMARY MALE INFERTILITY: A PILOT STUDY. A MAJORITY OF THE CASES OF PRIMARY MALE INFERTILITY ARE IDIOPATHIC WITH THE UNDERLYING MOLECULAR MECHANISMS CONTRIBUTING TO THE PATHOPHYSIOLOGY AS YET UNKNOWN. EFFECTS OF THE ENVIRONMENT CAN ALTER THE SPERM EPIGENOME THEREBY IMPACTING MALE REPRODUCTIVE HEALTH. EPIGENETIC MECHANISMS ARE CRUCIAL TO UNDERSTANDING HEALTH AND DISEASE, AND METHYLOME ALTERATIONS ARE NOW KNOWN TO HAVE FAR-REACHING CLINICAL IMPLICATIONS. HERE, WE REPORT THE RESULTS FROM OUR PILOT STUDY, A FIRST OF ITS KIND ANALYSIS OF THE EFFECT OF THE TRADITIONAL PRACTICE OF YOGA ON HUMAN SPERM QUALITY. WE FIND MARKED IMPROVEMENT IN SPERM CHARACTERISTICS IN PATIENTS OF IDIOPATHIC MALE INFERTILITY FOLLOWING A SUPERVISED 21-DAY YOGA REGIMEN. FURTHERMORE, NEXT-GENERATION SEQUENCING-BASED METHYLOME ANALYSIS REVEALS ALTERATIONS IN THE SPERM EPIGENOME OF THESE PATIENTS. WE FIND THAT THE PRACTICE OF YOGA IS ASSOCIATED WITH DNA METHYLATION CHANGES AT NEARLY 400 GENES, 147 OF WHICH WERE HYPERMETHYLATED WHILE 229 WERE HYPOMETHYLATED. THESE INCLUDED PROMOTERS OF SEVERAL GENES LINKED TO MAINTENANCE OF FERTILITY AND GENOMIC INTEGRITY. THIS NOVEL PIECE OF WORK DRAWS A DIRECT LINK BETWEEN POSITIVE LIFESTYLE PRACTICES AND MALE REPRODUCTIVE HEALTH. 2020 2 1639 23 MODULATION OF IMMUNE RESPONSES IN STRESS BY YOGA. STRESS IS A CONSTANT FACTOR IN TODAY'S FASTPACED LIFE THAT CAN JEOPARDIZE OUR HEALTH IF LEFT UNCHECKED. IT IS ONLY IN THE LAST HALF CENTURY THAT THE ROLE OF STRESS IN EVERY AILMENT FROM THE COMMON COLD TO AIDS HAS BEEN EMPHASIZED, AND THE MECHANISMS INVOLVED IN THIS PROCESS HAVE BEEN STUDIED. STRESS INFLUENCES THE IMMUNE RESPONSE PRESUMABLY THROUGH THE ACTIVATION OF THE HYPOTHALAMIC-PITUITARY ADRENAL AXIS, HYPOTHALAMIC PITUITARY-GONADAL AXIS, AND THE SYMPATHETIC-ADRENAL-MEDULLARY SYSTEM. VARIOUS NEUROTRANSMITTERS, NEUROPEPTIDES, HORMONES, AND CYTOKINES MEDIATE THESE COMPLEX BIDIRECTIONAL INTERACTIONS BETWEEN THE CENTRAL NERVOUS SYSTEM (CNS) AND THE IMMUNE SYSTEM. THE EFFECTS OF STRESS ON THE IMMUNE RESPONSES RESULT IN ALTERATIONS IN THE NUMBER OF IMMUNE CELLS AND CYTOKINE DYSREGULATION. VARIOUS STRESS MANAGEMENT STRATEGIES SUCH AS MEDITATION, YOGA, HYPNOSIS, AND MUSCLE RELAXATION HAVE BEEN SHOWN TO REDUCE THE PSYCHOLOGICAL AND PHYSIOLOGICAL EFFECTS OF STRESS IN CANCERS AND HIV INFECTION. THIS REVIEW AIMS TO DISCUSS THE EFFECT OF STRESS ON THE IMMUNE SYSTEM AND EXAMINE HOW RELAXATION TECHNIQUES SUCH AS YOGA AND MEDITATION COULD REGULATE THE CYTOKINE LEVELS AND HENCE, THE IMMUNE RESPONSES DURING STRESS. 2008 3 447 13 CHANGED PATTERN OF REGIONAL GLUCOSE METABOLISM DURING YOGA MEDITATIVE RELAXATION. USING POSITRON EMISSION TOMOGRAPHY (PET), MEASUREMENTS OF THE REGIONAL CEREBRAL METABOLIC RATE OF GLUCOSE (RCMRGLC) ARE ABLE TO DELINEATE CEREBRAL METABOLIC RESPONSES TO EXTERNAL OR MENTAL STIMULATION. IN ORDER TO EXAMINE POSSIBLE CHANGES OF BRAIN METABOLISM DUE TO YOGA MEDITATION PET SCANS WERE PERFORMED IN 8 MEMBERS OF A YOGA MEDITATION GROUP DURING THE NORMAL CONTROL STATE (C) AND YOGA MEDITATIVE RELAXATION (YMR). WHEREAS THERE WERE INTRAINDIVIDUAL CHANGES OF THE TOTAL CMRGLC, THE ALTERATIONS WERE NOT SIGNIFICANT FOR INTERGROUP COMPARISON; SPECIFIC FOCAL CHANGES OR CHANGES IN THE INTERHEMISPHERIC DIFFERENCES IN METABOLISM WERE ALSO NOT SEEN; HOWEVER THE RATIOS OF FRONTAL VS. OCCIPITAL RCMRGLC WERE SIGNIFICANTLY ELEVATED (P LESS THAN 0.05) DURING YMR. THESE ALTERED RATIOS WERE CAUSED BY A SLIGHT INCREASE OF FRONTAL RCMRGLC AND A MORE PRONOUNCED REDUCTION IN PRIMARY AND SECONDARY VISUAL CENTERS. THESE DATA INDICATE A HOLISTIC BEHAVIOR OF THE BRAIN METABOLISM DURING THE TIME OF ALTERED STATE OF CONSCIOUSNESS DURING YMR. 1990 4 1925 21 ROLE OF YOGA IN ALIENATING THE MEMORY DECLINE AND FRONTAL LOBE METABOLITE CHANGES IN TYPE 2 DIABETES. RECENT RESEARCH STUDIES HAVE ESTABLISHED THE FACT, THAT GLYCOSYLATION IS CAUSING THE MEMORY DECLINE AND THIS IS FURTHER SUPPORTED BY THE ALTERATION OF BRAIN METABOLITE CONCENTRATIONS IN DIABETES. THE PRESENT STUDY IS HYPOTHESIZED THAT YOGA IS HAVING ALIENATING ABILITY OF MEMORY DECLINE AND ALTERATION OF FRONTAL LOBE METABOLITE CONCENTRATIONS, WHICH ARE THE RESULT OF GLYCOSYLATION IN TYPE 2 DIABETES. FIVE TYPE 2 DIABETIC SUBJECTS OF BOTH THE SEX, AGED BETWEEN 35-55 YEARS, WHO PRACTICED YOGA OVER A PERIOD OF SIX MONTHS IN A YOGA INSTITUTE, WERE RECRUITED AS TEST GROUP. AGE AND SEX MATCHED FIVE TYPE 2 DIABETIC SUBJECTS WERE RECRUITED AS CONTROL GROUP, BOTH THE GROUP SUBJECTS ARE ON ORAL HYPOGLYCAEMIC AGENTS. GLYCOSYLATED HAEMOGLOBIN PERCENTAGE WAS ESTIMATED WITH BIO-RAD INSTRUMENT, FRONTAL LOBE METABOLITES WERE ESTIMATED WITH PROTON MAGNETIC RESONANCE SPECTROSCOPY (H-MRS), MEMORY WAS CALCULATED WITH PGI-MEMORY SCALE (PGIMS) THAT IS A PART OF PGI-BATTERY OF BRAIN DYSFUNCTION (PGI-BBD), WHICH IS A NEUROPSYCHOLOGICAL BATTERY. MEAN GLYCOSYLATED HAEMOGLOBIN PERCENTAGE AND MEMORY DYSFUNCTION RATING IN CONTROL AND TEST GROUP SUBJECTS ARE 6.9+/-0.4 & 7.8+/-1.84 (P=0.03), AND 14+/-1& 6+/-1 (P=0.0001) RESPECTIVELY. RIGHT AND LEFT FRONTAL LOBE N-ACETYL ASPARTATE (NAA) AND MYOIONOSITOL (MI) CONCENTRATIONS WERE MORE OR LESS SIMILAR IN BOTH THE GROUPS. YOGA IS HAVING A SIGNIFICANT ROLE IN ALIENATING THE DECLINE IN MEMORY CAUSED BY GLYCOSYLATION IN TYPE 2 DIABETES BUT NOT ON THE ALTERATION OF FRONTAL LOBE NAA AND MI CONCENTRATIONS. 2016 5 1668 28 NEUROCOGNITIVE CORRELATES OF THE EFFECTS OF YOGA MEDITATION PRACTICE ON EMOTION AND COGNITION: A PILOT STUDY. MINDFULNESS MEDITATION INVOLVES ATTENDING TO EMOTIONS WITHOUT COGNITIVE FIXATION OF EMOTIONAL EXPERIENCE. OVER TIME, THIS PRACTICE IS HELD TO PROMOTE ALTERATIONS IN TRAIT AFFECTIVITY AND ATTENTIONAL CONTROL WITH RESULTANT EFFECTS ON WELL-BEING AND COGNITION. HOWEVER, RELATIVELY LITTLE IS KNOWN REGARDING THE NEURAL SUBSTRATES OF MEDITATION EFFECTS ON EMOTION AND COGNITION. THE PRESENT STUDY INVESTIGATED THE NEUROCOGNITIVE CORRELATES OF EMOTION INTERFERENCE ON COGNITION IN YOGA PRACTITIONERS AND A MATCHED CONTROL GROUP (CG) UNDERWENT FMRI WHILE PERFORMING AN EVENT-RELATED AFFECTIVE STROOP TASK. THE TASK INCLUDES IMAGE VIEWING TRIALS AND STROOP TRIALS BRACKETED BY NEUTRAL OR NEGATIVE EMOTIONAL DISTRACTORS. DURING IMAGE VIEWING TRIALS, YOGA PRACTITIONERS EXHIBITED LESS REACTIVITY IN RIGHT DORSOLATERAL PREFRONTAL CORTEX (DLPFC) TO NEGATIVE AS COMPARED TO NEUTRAL IMAGES; WHEREAS THE CG HAD THE OPPOSITE PATTERN. A MAIN EFFECT OF VALENCE (NEGATIVE > NEUTRAL) WAS OBSERVED IN LIMBIC REGIONS (E.G., AMYGDALA), OF WHICH THE MAGNITUDE WAS INVERSELY RELATED TO DLPFC ACTIVATION. EXPLORATORY ANALYSES REVEALED THAT THE MAGNITUDE OF AMYGDALA ACTIVATION PREDICTED DECREASED SELF-REPORTED POSITIVE AFFECT IN THE CG, BUT NOT AMONG YOGA PRACTITIONERS. DURING STROOP TRIALS, YOGA PRACTITIONERS HAD GREATER ACTIVATION IN VENTROLATERAL PREFRONTAL CORTEX (VLPFC) DURING STROOP TRIALS WHEN NEGATIVE, COMPARED TO NEUTRAL, EMOTIONAL DISTRACTOR WERE PRESENTED; THE CG EXHIBITED THE OPPOSITE PATTERN. TAKEN TOGETHER, THESE DATA SUGGEST THAT THOUGH YOGA PRACTITIONERS EXHIBIT LIMBIC REACTIVITY TO NEGATIVE EMOTIONAL STIMULI, SUCH REACTIVITY DOES NOT HAVE DOWNSTREAM EFFECTS ON LATER MOOD STATE. THIS UNCOUPLING OF VIEWING NEGATIVE EMOTIONAL IMAGES AND AFFECT AMONG YOGA PRACTITIONERS MAY BE OCCASIONED BY THEIR SELECTIVE IMPLEMENTATION OF FRONTAL EXECUTIVE-DEPENDENT STRATEGIES TO REDUCE EMOTIONAL INTERFERENCE DURING COMPETING COGNITIVE DEMANDS AND NOT DURING EMOTIONAL PROCESSING PER SE. 2012 6 369 14 AUTONOMIC FUNCTIONS IN RAJA-YOGA MEDITATORS. STRESS, AN INEVITABLE AND CONSTANT FEATURE THROUGHOUT THE LIFETIME, INDUCES AUTONOMIC DYSFUNCTIONS, FOR WHICH MEDITATION IS CONSIDERED TO BE AN ANTIDOTE. SO THE CASE CONTROL STUDY WAS PLANNED INCLUDING 50 RAJA-YOGA MEDITATORS PRACTICING MEDITATION FOR 5 YEARS AND 50 AGE MATCHED NON-MEDITATORS. AUTONOMIC FUNCTION TESTS WERE PERFORMED AND RESULTS WERE COMPARED USING THE STUDENT-T TEST. MEAN VALUES OF RESTING HR, SBP AND DBP WERE LESS IN MEDITATORS. GALVANIC SKIN RESPONSE IN MEDITATORS WAS SIGNIFICANTLY MORE (P < 0.001). MEAN INCREASE BP RESPONSE TO HAND GRIP TEST AND COLD PRESSOR TEST WAS SIGNIFICANTLY LESS IN MEDITATORS THAN NON-MEDITATORS (P < 0.001). STANDING: LYING RATIO, VALSALVA RATIO, INSPIRATION: EXPIRATION RATIO AND 30:15 RATIOS WERE SIGNIFICANTLY INCREASED IN MEDITATORS THAN NON-MEDITATORS. FROM THE RESULTS, THERE WAS SHIFTING OF THE AUTONOMIC BALANCE TO PARASYMPATHETIC SIDE IN RAJA-YOGA MEDITATORS, WHICH SUGGESTS ITS UTILITY TO COMBAT THE ILL EFFECTS OF STRESS. 2015 7 1836 14 PSYCHOPHYSIOLOGICAL CORRELATES OF THE PRACTICE OF TANTRIC YOGA MEDITATION. AUTONOMIC AND ELECTROENCEPHALOGRAPHIC (EEG) CORRELATES OF TANTRIC YOGA MEDITATION WERE STUDIED IN THREE GROUPS OF SUBJECTS AS THEY PROGRESSED FROM NORMAL CONSCIOUSNESS INTO MEDITATION. GROUPS DIFFERED IN THEIR LEVEL OF MEDITATION PROFICIENCY. MEASURES OF SKIN RESISTANCE, HEART RATE, RESPIRATION, AUTONOMIC ORIENTING RESPONSES, RESTING EEG, EEG ALPHA AND THETA FREQUENCIES, SLEEP-SCORED EEG, AVERAGED EVOKED RESPONSES, AND SUBJECTIVE EXPERIENCE WERE EMPLOYED. UNLIKE MOST PREVIOUSLY REPORTED MEDITATION STUDIES, PROFICIENT MEDITATORS DEMONSTRATED INCREASED AUTONOMIC ACTIVATION DURING MEDITATION WHILE UNEXPERIENCED MEDITATORS DEMONSTRATED AUTONOMIC RELAXATION. DURING MEDITATION, PROFICIENT MEDITATORS DEMONSTRATED INCREASED ALPHA AND THETA POWER, MINIMAL EVIDENCE OF EEG-DEFINED SLEEP, AND DECREASED AUTONOMIC ORIENTING TO EXTERNAL STIMULATION. AN EPISODE OF SUDDEN AUTONOMIC ACTIVATION WAS OBSERVED THAT WAS CHARACTERIZED BY THE MEDITATOR AS AN APPROACH TO THE YOGIC ECSTATIC STATE OF INTENSE CONCENTRATION. THESE FINDINGS CHALLENGE THE CURRENT "RELAXATION" MODEL OF MEDITATIVE STATES. 1978 8 1641 16 MONITORING THE NEURAL ACTIVITY OF THE STATE OF MENTAL SILENCE WHILE PRACTICING SAHAJA YOGA MEDITATION. OBJECTIVE: TO IDENTIFY THE NEURAL CORRELATES OF THE STATE OF MENTAL SILENCE AS EXPERIENCED THROUGH SAHAJA YOGA MEDITATION. DESIGN: NINETEEN EXPERIENCED MEDITATORS UNDERWENT FUNCTIONAL MAGNETIC RESONANCE IMAGING DURING THREE SHORT CONSECUTIVE MEDITATION PERIODS, CONTRASTED WITH A CONTROL RELAXATION CONDITION. RESULTS: RELATIVE TO BASELINE, AT THE BEGINNING OF THE MEDITATION SESSIONS THERE WAS A SIGNIFICANT INCREASE OF ACTIVATION IN BILATERAL INFERIOR FRONTAL AND TEMPORAL REGIONS. ACTIVATION BECAME PROGRESSIVELY MORE REDUCED WITH DEEPER MEDITATION STAGES AND IN THE LAST MEDITATION SESSION IT BECAME LOCALIZED TO THE RIGHT INFERIOR FRONTAL CORTEX/ RIGHT INSULA AND RIGHT MIDDLE/SUPERIOR TEMPORAL CORTEX. FURTHERMORE, RIGHT INFERIOR FRONTAL ACTIVATION WAS DIRECTLY ASSOCIATED WITH THE SUBJECTIVE DEPTH OF THE MENTAL SILENCE EXPERIENCE. CONCLUSIONS: MEDITATORS APPEAR TO PASS THROUGH AN INITIAL INTENSE NEURAL SELF-CONTROL PROCESS NECESSARY TO SILENCE THEIR MIND. AFTER THIS THEY EXPERIENCE RELATIVELY REDUCED BRAIN ACTIVATION CONCOMITANT WITH THE DEEPENING OF THE STATE OF MENTAL SILENCE OVER RIGHT INFERIOR FRONTAL CORTEX, PROBABLY REFLECTING AN EFFORTLESS PROCESS OF ATTENTIONAL CONTEMPLATION ASSOCIATED WITH THIS STATE. 2015 9 1775 13 PRACTICE OF YOGA MAY CAUSE DAMAGE OF BOTH SCIATIC NERVES: A CASE REPORT. SCIATIC NERVE TRAUMATIC DAMAGE VERY RARELY OCCURS BILATERALLY. WE DESCRIBE THE CASE OF A 67-YEAR-OLD WOMAN WHO REPORTED A BILATERAL TRAUMATIC LESION OF THE SCIATIC NERVE DURING PRACTICE OF YOGA. NERVE CONDUCTION STUDIES SHOWED A BILATERAL SCIATIC NERVE NEUROPATHY, MOSTLY AFFECTING THE PERONEAL COMPONENT. LUMBAR PLEXUS MRI DOCUMENTED REGULAR ANATOMICAL FEATURES OF THE MAIN PRINCIPAL NERVE ROOTS WITH BILATERAL T2 SIGNAL ALTERATION OF ROOTS L4, L5 AND S1 THAT EXTENDED INTO THE SCIATIC NERVES SHOWING BOTH INCREASE IN SIZE, PROBABLY RELATED TO CHRONIC INJURY OF NERVES, AND AN ALTERATION IN DIFFUSION SIGNAL THAT SUGGESTED A RECENT ACUTE OVERLAPPED PROCESS. 2013 10 2067 26 THE CONSCIOUSNESS STATE OF TRADITIONAL NIDRA YOGA/MODERN YOGA NIDRA: PHENOMENOLOGICAL CHARACTERIZATION AND PRELIMINARY INSIGHTS FROM AN EEG STUDY. NIDRA YOGA IS AN ANCIENT YOGIC PRACTICE CAPABLE OF INDUCING ALTERED STATES OF CONSCIOUSNESS CHARACTERIZED BY DEEP RELAXATION, STRONG CONCENTRATION, ACUTE SELF-AWARENESS, AND JOY. IN MODERN CONTEMPLATIVE NEUROSCIENCE LANGUAGE, IT IS KNOWN BY THE NAME YOGA NIDRA, AND FEW STUDIES HAVE INVESTIGATED ITS PHENOMENOLOGICAL AND PSYCHOPHYSIOLOGICAL EFFECTS. SIX HEALTHY VOLUNTEERS (FOUR FEMALES AGED 31-74) PERFORMED 12 YOGA NIDRA SESSIONS GUIDED BY AN EXPERT DURING A 6-DAY RETREAT. EACH SESSION CONSISTED OF 10 MINUTES IN A RESTING STATE (BASELINE) FOLLOWED BY 2 HOURS OF YOGA NIDRA. PSYCHOMETRIC DATA REGARDING DISSOCIATIVE EXPERIENCES (CLINICIAN ADMINISTERED DISSOCIATIVE STATES SCALE) AND THE STATE OF CONSCIOUSNESS (PHENOMENOLOGY OF CONSCIOUSNESS INVENTORY) WERE COLLECTED AFTER BASELINE AND YOGA NIDRA, WHILE HIGH-DENSITY EEG WAS RECORDED DURING THE ENTIRE SESSION. DURING NIDRA SESSIONS, NO SLEEP HALLMARKS (I.E., K-COMPLEXES AND SLEEP SPINDLES) WERE DETECTED BY THE EEG IN ANY SUBJECT. PSYCHOMETRIC DATA WE RE ANALYZED USING A WILCOXON SIGNED-RANK TEST CORRECTED WITH THE FALSE DISCOVERY RATE APPROACH FOR MULTIPLE COMPARISONS. COMPARED TO BASELINE, YOGA NIDRA PRACTICE WAS RELATED TO: (1) INCREASED DISSOCIATIVE EFFECTS (P = 0.022); (2) PERCEPTION OF BEING IN AN ALTERED STATE OF CONSCIOUSNESS (P = 0.026); (3) ALTERATIONS IN PERCEIVED BODY IMAGE (P = 0.022); (4) INCREASED "MEANINGFULNESS" ATTRIBUTED TO THE EXPERIENCE (P = 0.026); (5) REDUCED RATIONAL THINKING (P = 0.029); AND (6) REDUCED VOLITIONAL THOUGHT CONTROL (P = 0.026). FIRST-PERSON EXPERIENCE IS DISCUSSED IN RELATION TO DESCRIPTIVE EEG POWER SPECTRAL DENSITY ANALYSIS, WHICH WAS PERFORMED IN ONE SUBJECT BECAUSE OF SEVERE EEG ARTIFACTS IN THE OTHER RECORDINGS; THAT SUBJECT SHOWED, COMPARED TO BASELINE: (1) EARLY INCREASE OF ALPHA AND BETA POWER, FOLLOWED BY A PROGRESSIVE WIDESPREAD REDUCTION; (2) WIDESPREAD EARLY INCREASE OF THETA POWER, FOLLOWED BY A PROGRESSIVE REDUCTION; AND (3) WIDESPREAD INCREASE OF GAMMA POWER IN THE LATEST STAGES. THE PRESENT PRELIMINARY RESULTS ENRICH THE KNOWLEDGE OF YOGA NIDRA, ELUCIDATING ITS PHENOMENOLOGY AND SUGGESTING SOME PSYCHOPHYSIOLOGICAL CORRELATES THAT FUTURE STUDIES MAY ADDRESS. 2021 11 1329 23 HIGH-FREQUENCY CEREBRAL ACTIVATION AND INTERHEMISPHERIC SYNCHRONIZATION FOLLOWING SUDARSHAN KRIYA YOGA AS GLOBAL BRAIN RHYTHMS: THE STATE EFFECTS. CONTEXT: RESPIRATION IS KNOWN TO MODULATE NEURONAL OSCILLATIONS IN THE BRAIN AND IS MEASURED BY ELECTROENCEPHALOGRAM (EEG). SUDARSHAN KRIYA YOGA (SKY) IS A POPULAR BREATHING PROCESS AND IS ESTABLISHED FOR ITS SIGNIFICANT EFFECTS ON THE VARIOUS ASPECTS OF PHYSIOLOGY AND PSYCHOLOGY. AIMS: THIS STUDY AIMED TO OBSERVE NEURONAL OSCILLATIONS IN MULTIFREQUENCY BANDS AND INTERHEMISPHERIC SYNCHRONIZATION FOLLOWING SKY. SETTINGS AND DESIGN: THIS STUDY EMPLOYED BEFORE- AND AFTER-STUDY DESIGN. SUBJECTS AND METHODS: FORTY HEALTHY VOLUNTEERS (AVERAGE AGE 25.45 +/- 5.75, 23 MALES AND 17 FEMALES) PARTICIPATED IN THE STUDY. NINETEEN-CHANNEL EEG WAS RECORDED AND ANALYZED FOR 5 MIN EACH: BEFORE AND AFTER SKY. SPECTRAL POWER FOR DELTA, THETA, ALPHA, BETA, AND GAMMA FREQUENCY BAND WAS CALCULATED USING MULTI-TAPER FAST FOURIER TRANSFORM (CHRONUX TOOLBOX). THE ASYMMETRY INDEX WAS CALCULATED BY SUBTRACTING THE NATURAL LOG OF POWERS OF LEFT (L) HEMISPHERE FROM THE RIGHT((R)) TO SHOW INTERHEMISPHERIC SYNCHRONIZATION. STATISTICAL ANALYSIS: PAIRED T-TEST WAS USED FOR STATISTICAL ANALYSIS. RESULTS: SPECTRAL POWER INCREASED SIGNIFICANTLY IN ALL FREQUENCY BANDS BILATERALLY IN FRONTAL, CENTRAL, PARIETAL, TEMPORAL, AND OCCIPITAL REGIONS OF THE BRAIN AFTER LONG SKY. ELECTRICAL ACTIVITY SHIFTED FROM LOWER TO HIGHER FREQUENCY RANGE WITH A SIGNIFICANT RISE IN THE GAMMA AND BETA POWERS FOLLOWING SKY. ASYMMETRY INDEX VALUES TENDED TOWARD 0 FOLLOWING SKY. CONCLUSIONS: A SINGLE SESSION OF SKY GENERATES GLOBAL BRAIN RHYTHM DOMINANTLY WITH HIGH-FREQUENCY CEREBRAL ACTIVATION AND INITIATES APPROPRIATE INTERHEMISPHERIC SYNCHRONIZATION IN BRAIN RHYTHMS AS STATE EFFECTS. THIS SUGGESTS THAT SKY LEADS TO BETTER ATTENTION, MEMORY, AND EMOTIONAL AND AUTONOMIC CONTROL ALONG WITH ENHANCED COGNITIVE FUNCTIONS, WHICH FINALLY IMPROVES PHYSICAL AND MENTAL WELL-BEING. 2020 12 1496 23 INTRACEREBRAL PAIN PROCESSING IN A YOGA MASTER WHO CLAIMS NOT TO FEEL PAIN DURING MEDITATION. WE RECORDED MAGNETOENCEPHALOGRAPHY (MEG) AND FUNCTIONAL MAGNETIC RESONANCE IMAGING (FMRI) FOLLOWING NOXIOUS LASER STIMULATION IN A YOGA MASTER WHO CLAIMS NOT TO FEEL PAIN WHEN MEDITATING. AS FOR BACKGROUND MEG ACTIVITY, THE POWER OF ALPHA FREQUENCY BANDS PEAKING AT AROUND 10 HZ WAS MUCH INCREASED DURING MEDITATION OVER OCCIPITAL, PARIETAL AND TEMPORAL REGIONS, WHEN COMPARED WITH THE NON-MEDITATIVE STATE, WHICH MIGHT MEAN THE SUBJECT WAS VERY RELAXED, THOUGH HE DID NOT FALL ASLEEP, DURING MEDITATION. PRIMARY PAIN-RELATED CORTICAL ACTIVITIES RECORDED FROM PRIMARY (SI) AND SECONDARY SOMATOSENSORY CORTICES (SII) BY MEG WERE VERY WEAK OR ABSENT DURING MEDITATION. AS FOR FMRI RECORDING, THERE WERE REMARKABLE CHANGES IN LEVELS OF ACTIVITY IN THE THALAMUS, SII-INSULA (MAINLY THE INSULA) AND CINGULATE CORTEX BETWEEN MEDITATION AND NON-MEDITATION. ACTIVITIES IN ALL THREE REGIONS WERE INCREASED DURING NON-MEDITATION, SIMILAR TO RESULTS IN NORMAL SUBJECTS. IN CONTRAST, ACTIVITIES IN ALL THREE REGIONS WERE WEAKER DURING MEDITATION, AND THE LEVEL WAS LOWER THAN THE BASELINE IN THE THALAMUS. RECENT NEUROIMAGING AND ELECTROPHYSIOLOGICAL STUDIES HAVE CLARIFIED THAT THE EMOTIONAL ASPECT OF PAIN PERCEPTION MAINLY INVOLVES THE INSULA AND CINGULATE CORTEX. THOUGH WE CANNOT CLEARLY EXPLAIN THIS UNUSUAL CONDITION IN THE YOGA MASTER, A CHANGE OF MULTIPLE REGIONS RELATING TO PAIN PERCEPTION COULD BE RESPONSIBLE, SINCE PAIN IS A COMPLEX SENSORY AND EMOTIONAL EXPERIENCE. 2005 13 1897 23 RESTING STATE FUNCTIONAL CONNECTIVITY ASSOCIATED WITH SAHAJA YOGA MEDITATION. NEUROSCIENCE RESEARCH HAS SHOWN THAT MEDITATION PRACTICES HAVE EFFECTS ON BRAIN STRUCTURE AND FUNCTION. HOWEVER, FEW STUDIES HAVE COMBINED INFORMATION ON THE EFFECTS ON STRUCTURE AND FUNCTION IN THE SAME SAMPLE. LONG-TERM DAILY MEDITATION PRACTICE PRODUCES REPEATED ACTIVITY OF SPECIFIC BRAIN NETWORKS OVER YEARS OF PRACTICE, WHICH MAY INDUCE LASTING STRUCTURAL AND FUNCTIONAL CONNECTIVITY (FC) CHANGES WITHIN RELEVANT CIRCUITS. THE AIM OF OUR STUDY WAS THEREFORE TO IDENTIFY DIFFERENCES IN FC DURING THE RESTING STATE BETWEEN 23 SAHAJA YOGA MEDITATION EXPERTS AND 23 HEALTHY PARTICIPANTS WITHOUT MEDITATION EXPERIENCE. SEED-BASED FC ANALYSIS WAS PERFORMED DEPARTING FROM VOXELS THAT HAD SHOWN STRUCTURAL DIFFERENCES BETWEEN THESE SAME PARTICIPANTS. THE CONTRAST OF CONNECTIVITY MAPS YIELDED THAT MEDITATORS SHOWED INCREASED FC BETWEEN THE LEFT VENTROLATERAL PREFRONTAL CORTEX AND THE RIGHT DORSOLATERAL PREFRONTAL CORTEX BUT REDUCED FC BETWEEN THE LEFT INSULA AND THE BILATERAL MID-CINGULATE AS WELL AS BETWEEN THE RIGHT ANGULAR GYRUS AND THE BILATERAL PRECUNEUS/CUNEUS CORTICES. IT THUS APPEARS THAT LONG-TERM MEDITATION PRACTICE INCREASES DIRECT FC BETWEEN VENTRAL AND DORSAL FRONTAL REGIONS WITHIN BRAIN NETWORKS RELATED TO ATTENTION AND COGNITIVE CONTROL AND DECREASES FC BETWEEN REGIONS OF THESE NETWORKS AND AREAS OF THE DEFAULT MODE NETWORK. 2021 14 1565 21 LOW AND THEN HIGH FREQUENCY OSCILLATIONS OF DISTINCT RIGHT CORTICAL NETWORKS ARE PROGRESSIVELY ENHANCED BY MEDIUM AND LONG TERM SATYANANDA YOGA MEDITATION PRACTICE. MEDITATION PROFICIENCY IS RELATED TO TRAIT-LIKE (LEARNED) EFFECTS ON BRAIN FUNCTION, DEVELOPED OVER TIME. PREVIOUS STUDIES SHOW INCREASES IN EEG POWER IN LOWER FREQUENCY BANDS (THETA, ALPHA) IN EXPERIENCED MEDITATORS IN BOTH MEDITATION STATES AND BASELINE CONDITIONS. HIGHER GAMMA BAND POWER HAS BEEN FOUND IN ADVANCED BUDDHIST MEDITATORS, YET IT IS NOT KNOWN IF THIS OCCURS IN YOGA MEDITATION PRACTICES. THIS STUDY USED ELORETA TO COMPARE DIFFERENCES IN CORTICAL SOURCE ACTIVITY UNDERLYING SCALP EEG FROM INTERMEDIATE (MEAN EXPERIENCE 4 YEARS) AND ADVANCED (MEAN EXPERIENCE 30 YEARS) AUSTRALIAN MEDITATORS FROM THE SATYANANDA YOGA TRADITION DURING A BODY-STEADINESS MEDITATION, MANTRA MEDITATION, AND NON-MEDITATION MENTAL CALCULATION CONDITION. INTERMEDIATE YOGA MEDITATORS SHOWED GREATER SOURCE ACTIVITY IN LOW FREQUENCIES (PARTICULARLY THETA AND ALPHA1) DURING MENTAL CALCULATION, BODY-STEADINESS AND MANTRA MEDITATION. A SIMILAR SPATIAL PATTERN OF SIGNIFICANT DIFFERENCES WAS FOUND IN ALL CONDITIONS BUT THE NUMBER OF SIGNIFICANT VOXELS WAS DOUBLE DURING BODY-STEADINESS AND MANTRA MEDITATION THAN IN THE NON-MEDITATION (CALCULATION) CONDITION. THESE DIFFERENCES WERE GREATEST IN RIGHT (R) SUPERIOR FRONTAL AND R PRECENTRAL GYRI AND EXTENDED BACK TO INCLUDE THE R PARIETAL AND OCCIPITAL LOBES. ADVANCED YOGA MEDITATORS SHOWED GREATER ACTIVITY IN HIGH FREQUENCIES (BETA AND ESPECIALLY GAMMA) IN ALL CONDITIONS BUT GREATLY EXPANDED DURING MEDITATION PRACTICE. ACROSS ALL CONDITIONS (MEDITATION AND NON-MEDITATION) DIFFERENCES WERE GREATEST IN THE SAME REGIONS: R INSULA, R INFERIOR FRONTAL GYRUS AND R ANTERIOR TEMPORAL LOBE. DISTINCT R CORE NETWORKS WERE IDENTIFIED IN ALPHA1 (8-10 HZ) AND GAMMA (25-42 HZ) BANDS, RESPECTIVELY. THE VOXELS RECRUITED TO THESE NETWORKS GREATLY EXPANDED DURING MEDITATION PRACTICE TO INCLUDE HOMOLOGOUS REGIONS OF THE LEFT HEMISPHERE. FUNCTIONAL INTERPRETATION PARALLELS TRADITIONALLY DESCRIBED STAGES OF DEVELOPMENT IN YOGA PROFICIENCY. 2014 15 1439 21 INCREASED GREY MATTER ASSOCIATED WITH LONG-TERM SAHAJA YOGA MEDITATION: A VOXEL-BASED MORPHOMETRY STUDY. OBJECTIVES: TO INVESTIGATE REGIONAL DIFFERENCES IN GREY MATTER VOLUME ASSOCIATED WITH THE PRACTICE OF SAHAJA YOGA MEDITATION. DESIGN: TWENTY THREE EXPERIENCED PRACTITIONERS OF SAHAJA YOGA MEDITATION AND TWENTY THREE NON-MEDITATORS MATCHED ON AGE, GENDER AND EDUCATION LEVEL, WERE SCANNED USING STRUCTURAL MAGNETIC RESONANCE IMAGING AND THEIR GREY MATTER VOLUME WERE COMPARED USING VOXEL-BASED MORPHOMETRY. RESULTS: GREY MATTER VOLUME WAS LARGER IN MEDITATORS RELATIVE TO NON-MEDITATORS ACROSS THE WHOLE BRAIN. IN ADDITION, GREY MATTER VOLUME WAS LARGER IN SEVERAL PREDOMINANTLY RIGHT HEMISPHERIC REGIONS: IN INSULA, VENTROMEDIAL ORBITOFRONTAL CORTEX, INFERIOR TEMPORAL AND PARIETAL CORTICES AS WELL AS IN LEFT VENTROLATERAL PREFRONTAL CORTEX AND LEFT INSULA. NO AREAS WITH LARGER GREY MATTER VOLUME WERE FOUND IN NON-MEDITATORS RELATIVE TO MEDITATORS. CONCLUSIONS: THE STUDY SHOWS THAT LONG-TERM PRACTICE OF SAHAJA YOGA MEDITATION IS ASSOCIATED WITH LARGER GREY MATTER VOLUME OVERALL, AND WITH REGIONAL ENLARGEMENT IN SEVERAL RIGHT HEMISPHERIC CORTICAL AND SUBCORTICAL BRAIN REGIONS THAT ARE ASSOCIATED WITH SUSTAINED ATTENTION, SELF-CONTROL, COMPASSION AND INTEROCEPTIVE PERCEPTION. THE INCREASED GREY MATTER VOLUME IN THESE ATTENTION AND SELF-CONTROL MEDIATING REGIONS SUGGESTS USE-DEPENDENT ENLARGEMENT WITH REGULAR PRACTICE OF THIS MEDITATION. 2016 16 1286 22 GRAY MATTER AND FUNCTIONAL CONNECTIVITY IN ANTERIOR CINGULATE CORTEX ARE ASSOCIATED WITH THE STATE OF MENTAL SILENCE DURING SAHAJA YOGA MEDITATION. SOME MEDITATION TECHNIQUES TEACH THE PRACTITIONER TO ACHIEVE THE STATE OF MENTAL SILENCE. THE AIM OF THIS STUDY WAS TO INVESTIGATE BRAIN REGIONS THAT ARE ASSOCIATED WITH THEIR VOLUME AND FUNCTIONAL CONNECTIVITY (FC) WITH THE DEPTH OF MENTAL SILENCE IN LONG-TERM PRACTITIONERS OF SAHAJA YOGA MEDITATION. TWENTY-THREE LONG-TERM PRACTITIONERS OF THIS MEDITATION WERE SCANNED USING MAGNETIC RESONANCE IMAGING. IN ORDER TO IDENTIFY THE NEURAL CORRELATES OF THE DEPTH OF MENTAL SILENCE, WE TESTED WHICH GRAY MATTER VOLUMES (GMV) WERE CORRELATED WITH THE DEPTH OF MENTAL SILENCE AND WHICH REGIONS THESE AREAS WERE FUNCTIONALLY CONNECTED TO UNDER A MEDITATION CONDITION. GMV IN MEDIAL PREFRONTAL CORTEX INCLUDING ROSTRAL ANTERIOR CINGULATE CORTEX WERE POSITIVELY CORRELATED WITH THE SUBJECTIVE PERCEPTION OF THE DEPTH OF MENTAL SILENCE INSIDE THE SCANNER. FURTHERMORE, THERE WAS SIGNIFICANTLY INCREASED FC BETWEEN THIS AREA AND BILATERAL ANTERIOR INSULA/PUTAMEN DURING A MEDITATION-STATE SPECIFICALLY, WHILE DECREASED CONNECTIVITY WITH THE RIGHT THALAMUS/PARAHIPPOCAMPAL GYRUS WAS PRESENT DURING THE MEDITATION-STATE AND THE RESTING-STATE. THE CAPACITY OF LONG-TERM MEDITATORS TO ESTABLISH A DURABLE STATE OF MENTAL SILENCE INSIDE AN MRI SCANNER WAS ASSOCIATED WITH LARGER GRAY MATTER VOLUME IN A MEDIAL FRONTAL REGION THAT IS CRUCIAL FOR TOP-DOWN COGNITIVE, EMOTION AND ATTENTION CONTROL. THIS IS FURTHERMORE CORROBORATED BY INCREASED FC OF THIS REGION DURING THE MEDITATION-STATE WITH BILATERAL ANTERIOR INSULA/PUTAMEN, WHICH ARE IMPORTANT FOR INTEROCEPTION, EMOTION, AND ATTENTION REGULATION. THE FINDINGS HENCE SUGGEST THAT THE DEPTH OF MENTAL SILENCE IS ASSOCIATED WITH MEDIAL FRONTO-INSULAR-STRIATAL NETWORKS THAT ARE CRUCIAL FOR TOP-DOWN ATTENTION AND EMOTIONAL CONTROL. 2018 17 2720 24 YOGA MEDITATION PRACTITIONERS EXHIBIT GREATER GRAY MATTER VOLUME AND FEWER REPORTED COGNITIVE FAILURES: RESULTS OF A PRELIMINARY VOXEL-BASED MORPHOMETRIC ANALYSIS. HATHA YOGA TECHNIQUES, INCLUDING PHYSICAL POSTURES (ASANAS), BREATHING EXERCISES (PRANAYAMA), AND MEDITATION, INVOLVE THE PRACTICE OF MINDFULNESS. IN TURN, YOGA MEDITATION PRACTICES MAY INDUCE THE STATE OF MINDFULNESS, WHICH, WHEN EVOKED RECURRENTLY THROUGH REPEATED PRACTICE, MAY ACCRUE INTO TRAIT OR DISPOSITIONAL MINDFULNESS. PUTATIVELY, THESE CHANGES MAY BE MEDIATED BY EXPERIENCE-DEPENDENT NEUROPLASTIC CHANGES. THOUGH PRIOR STUDIES HAVE IDENTIFIED DIFFERENCES IN GRAY MATTER VOLUME (GMV) BETWEEN LONG-TERM MINDFULNESS PRACTITIONERS AND CONTROLS, NO STUDIES TO DATE HAVE REPORTED ON WHETHER YOGA MEDITATION IS ASSOCIATED WITH GMV DIFFERENCES. THE PRESENT STUDY INVESTIGATED GMV DIFFERENCES BETWEEN YOGA MEDITATION PRACTITIONERS (YMP) AND A MATCHED CONTROL GROUP (CG). THE YMP GROUP EXHIBITED GREATER GM VOLUME IN FRONTAL, LIMBIC, TEMPORAL, OCCIPITAL, AND CEREBELLAR REGIONS; WHEREAS THE CG HAD NO GREATER REGIONAL GREATER GMV. IN ADDITION, THE YMP GROUP REPORTED SIGNIFICANTLY FEWER COGNITIVE FAILURES ON THE COGNITIVE FAILURES QUESTIONNAIRE (CFQ), THE MAGNITUDE OF WHICH WAS POSITIVELY CORRELATED WITH GMV IN NUMEROUS REGIONS IDENTIFIED IN THE PRIMARY ANALYSIS. LASTLY, GMV WAS POSITIVELY CORRELATED WITH THE DURATION OF YOGA PRACTICE. RESULTS FROM THIS PRELIMINARY STUDY SUGGEST THAT HATHA YOGA PRACTICE MAY BE ASSOCIATED WITH THE PROMOTION OF NEUROPLASTIC CHANGES IN EXECUTIVE BRAIN SYSTEMS, WHICH MAY CONFER THERAPEUTIC BENEFITS THAT ACCRUE WITH REPEATED PRACTICE. 2012 18 1545 25 LARGER WHOLE BRAIN GREY MATTER ASSOCIATED WITH LONG-TERM SAHAJA YOGA MEDITATION: A DETAILED AREA BY AREA COMPARISON. OBJECTIVES: OUR PREVIOUS STUDY SHOWED THAT LONG-TERM PRACTITIONERS OF SAHAJA YOGA MEDITATION (SYM) HAD AROUND 7% LARGER GREY MATTER VOLUME (GMV) IN THE WHOLE BRAIN COMPARED WITH HEALTHY CONTROLS; HOWEVER, WHEN TESTING INDIVIDUAL REGIONS, ONLY 5 SMALL BRAIN AREAS WERE STATISTICALLY DIFFERENT BETWEEN GROUPS. UNDER THE HYPOTHESIS THAT THOSE RESULTS WERE STATISTICALLY CONSERVATIVE, WITH THE SAME DATASET, WE INVESTIGATED IN MORE DETAIL THE REGIONAL DIFFERENCES IN GMV ASSOCIATED WITH THE PRACTICE OF SYM, WITH A DIFFERENT STATISTICAL APPROACH. DESIGN: TWENTY-THREE EXPERIENCED PRACTITIONERS OF SYM AND 23 HEALTHY NON-MEDITATORS MATCHED ON AGE, SEX AND EDUCATION LEVEL, WERE SCANNED USING STRUCTURAL MAGNETIC RESONANCE IMAGING (MRI). THEIR GMV WERE EXTRACTED AND COMPARED USING VOXEL-BASED MORPHOMETRY (VBM). USING A NOVEL AD-HOC GENERAL LINEAR MODEL, STATISTICAL COMPARISONS WERE MADE TO OBSERVE IF THE GMV DIFFERENCES BETWEEN MEDITATORS AND CONTROLS WERE STATISTICALLY SIGNIFICANT. RESULTS: IN THE 16 LOBE AREA SUBDIVISIONS, GMV WAS STATISTICALLY SIGNIFICANTLY DIFFERENT IN 4 OUT OF 16 AREAS: IN RIGHT HEMISPHERIC TEMPORAL AND FRONTAL LOBES, LEFT FRONTAL LOBE AND BRAINSTEM. IN THE 116 AAL AREA SUBDIVISIONS, GMV DIFFERENCE WAS STATISTICALLY SIGNIFICANT IN 11 AREAS. THE GMV DIFFERENCES WERE STATISTICALLY MORE SIGNIFICANT IN RIGHT HEMISPHERIC BRAIN AREAS. CONCLUSIONS: THE STUDY SHOWS THAT LONG-TERM PRACTICE OF SYM IS ASSOCIATED WITH LARGER GMV OVERALL, AND WITH SIGNIFICANT DIFFERENCES MAINLY IN TEMPORAL AND FRONTAL AREAS OF THE RIGHT HEMISPHERE AND THE BRAINSTEM. THESE NEUROPLASTIC CHANGES MAY REFLECT EMOTIONAL AND ATTENTIONAL CONTROL MECHANISMS DEVELOPED WITH SYM. ON THE OTHER HAND, OUR STATISTICAL AD-HOC METHOD SHOWS THAT THERE WERE MORE BRAIN AREAS WITH STATISTICAL SIGNIFICANCE COMPARED TO THE TRADITIONAL METHODOLOGY WHICH WE THINK IS SUSCEPTIBLE TO CONSERVATIVE TYPE II ERRORS. 2020 19 887 11 EFFECT OF YOGA TYPE BREATHING ON HEART RATE AND CARDIAC AXIS OF NORMAL SUBJECTS. EFFECT OF INSPIRATORY AND EXPIRATORY PHASES OF NORMAL QUIET BREATHING, DEEP BREATHING AND SAVITRI PRANAYAM TYPE BREATHING ON HEART RATE AND MEAN VENTRICULAR QRS AXIS WAS INVESTIGATED IN YOUNG, HEALTHY UNTRAINED SUBJECTS. PRANAYAM TYPE BREATHING PRODUCED SIGNIFICANT CARDIOACCELERATION AND INCREASE IN QRS AXIS DURING THE INSPIRATORY PHASE AS COMPARED TO EUPNEA. ON THE OTHER HAND, EXPIRATORY EFFORT DURING PRANAYAM TYPE BREATHING DID NOT PRODUCE ANY SIGNIFICANT CHANGE IN HEART RATE OR QRS AXIS. THE CHANGES IN HEART RATE AND QRS AXIS DURING THE INSPIRATORY AND EXPIRATORY PHASES OF PRANAYAM TYPE BREATHING WERE SIMILAR TO THE CHANGES OBSERVED DURING THE CORRESPONDING PHASES OF DEEP BREATHING. 1986 20 749 21 EFFECT OF SAHAJA YOGA PRACTICE ON SEIZURE CONTROL & EEG CHANGES IN PATIENTS OF EPILEPSY. THE EFFECT OF SAHAJA YOGA MEDITATION ON SEIZURE CONTROL AND ELECTROENCEPHALOGRAPHIC ALTERATIONS WAS ASSESSED IN 32 PATIENTS OF IDIOPATHIC EPILEPSY. THE SUBJECTS WERE RANDOMLY DIVIDED INTO 3 GROUPS. GROUP I (N = 10) PRACTISED SAHAJA YOGA FOR 6 MONTHS, GROUP II (N = 10) PRACTISED EXERCISES MIMICKING SAHAJA YOGA FOR 6 MONTHS AND GROUP III (N = 12) SERVED AS THE EPILEPTIC CONTROL GROUP. GROUP I SUBJECTS REPORTED A 62 PER CENT DECREASE IN SEIZURE FREQUENCY AT 3 MONTHS AND A FURTHER DECREASE OF 86 PER CENT AT 6 MONTHS OF INTERVENTION. POWER SPECTRAL ANALYSIS OF EEG SHOWED A SHIFT IN FREQUENCY FROM 0-8 HZ TOWARDS 8-20 HZ. THE RATIOS OF EEG POWERS IN DELTA (D), THETA (T), ALPHA (A) AND BETA (B) BANDS I.E., A/D, A/D + T, A/T AND A + B/D + T WERE INCREASED. PER CENT D POWER DECREASED AND PER CENT A INCREASED. NO SIGNIFICANT CHANGES IN ANY OF THE PARAMETERS WERE FOUND IN GROUPS II AND III, INDICATING THAT SAHAJA YOGA PRACTICE BRINGS ABOUT SEIZURE REDUCTION AND EEG CHANGES. SAHAJA YOGA COULD PROVE TO BE BENEFICIAL IN THE MANAGEMENT OF PATIENTS OF EPILEPSY. 1996