1 2038 168 TELOMERASE ACTIVITY AND CELLULAR AGING MIGHT BE POSITIVELY MODIFIED BY A YOGA-BASED LIFESTYLE INTERVENTION. OBJECTIVES: RECENT STUDIES SHOWED THAT A BRIEF YOGA-BASED LIFESTYLE INTERVENTION WAS EFFICACIOUS IN REDUCING LEVELS OF OXIDATIVE STRESS AND CELLULAR AGING IN OBESE MEN. THE OBJECTIVE OF THIS CASE REPORT WAS TO ASSESS THE EFFICACY OF THIS INTERVENTION IN REDUCING THE LEVELS OF BIOCHEMICAL MARKERS OF CELLULAR AGEING, OXIDATIVE STRESS, AND INFLAMMATION AT BASELINE (DAY 0), AT THE END OF ACTIVE INTERVENTION (DAY 10), AND FOLLOW-UP AT DAY 90. DESIGN: SINGLE CASE REPORT FROM A PROSPECTIVE ONGOING STUDY WITH PRE-POST DESIGN ASSESSING THE LEVEL OF VARIOUS MARKERS OF CELLULAR AGING. SETTING: INTEGRAL HEALTH CLINIC, AN OUTPATIENT FACILITY CONDUCTING MEDITATION AND YOGA-BASED LIFESTYLE INTERVENTION PROGRAMS FOR MANAGEMENT OF CHRONIC DISEASES. PATIENT: A 31-YEAR-OLD MAN WITH CLASS I OBESITY (BODY-MASS INDEX, 29.5 KG/M(2)) WHO PRESENTED TO THE MEDICINE OUTPATIENT DEPARTMENT AT ALL INDIA INSTITUTE OF MEDICAL SCIENCES, NEW DELHI, INDIA, WITH A HISTORY OF FATIGUE, DIFFICULTY LOSING WEIGHT, AND LACK OF MOTIVATION. HE NOTED A MARKED DECREASE IN HIS ENERGY LEVEL, PARTICULARLY IN THE AFTERNOON. INTERVENTION: A PRETESTED INTERVENTION PROGRAM INCLUDED ASANAS (POSTURES), PRANAYAMA (BREATHING EXERCISES), STRESS MANAGEMENT, GROUP DISCUSSIONS, LECTURES, AND INDIVIDUALIZED ADVICE. RESULTS: FROM BASELINE (DAY 0) TO DAY 90, THE ACTIVITY OF TELOMERASE AND LEVELS OF BETA-ENDORPHINS, PLASMA CORTISOL, AND INTERLEUKIN-6 INCREASED, AND A SUSTAINED REDUCTION IN OXIDATIVE STRESS MARKERS, SUCH AS REACTIVE OXYGEN SPECIES AND 8-HYDROXY-2-DEOXY-GUANOSINE LEVELS. CONCLUSIONS: ADOPTING YOGA/MEDITATION-BASED LIFESTYLE MODIFICATION CAUSES REVERSAL OF MARKERS OF AGING, MAINLY OXIDATIVE STRESS, TELOMERASE ACTIVITY, AND OXIDATIVE DNA DAMAGE. THIS MAY NOT ONLY DELAY AGING AND PROLONG A YOUTHFUL HEALTHY LIFE BUT ALSO DELAY OR PREVENT ONSET OF SEVERAL LIFESTYLE-RELATED DISEASES, OF WHICH OXIDATIVE STRESS AND INFLAMMATION ARE THE CHIEF CAUSE. THIS REPORT SUGGESTS THIS SIMPLE LIFESTYLE INTERVENTION MAY BE THERAPEUTIC FOR OXIDATIVE DNA DAMAGE AND OXIDATIVE STRESS.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
2 1392  42 IMPACT OF YOGA AND MEDITATION ON CELLULAR AGING IN APPARENTLY HEALTHY INDIVIDUALS: A PROSPECTIVE, OPEN-LABEL SINGLE-ARM EXPLORATORY STUDY. THIS STUDY WAS DESIGNED TO EXPLORE THE IMPACT OF YOGA AND MEDITATION BASED LIFESTYLE INTERVENTION (YMLI) ON CELLULAR AGING IN APPARENTLY HEALTHY INDIVIDUALS. DURING THIS 12-WEEK PROSPECTIVE, OPEN-LABEL, SINGLE ARM EXPLORATORY STUDY, 96 APPARENTLY HEALTHY INDIVIDUALS WERE ENROLLED TO RECEIVE YMLI. THE PRIMARY ENDPOINTS WERE ASSESSMENT OF THE CHANGE IN LEVELS OF CARDINAL BIOMARKERS OF CELLULAR AGING IN BLOOD FROM BASELINE TO WEEK 12, WHICH INCLUDED DNA DAMAGE MARKER 8-HYDROXY-2'-DEOXYGUANOSINE (8-OH2DG), OXIDATIVE STRESS MARKERS REACTIVE OXYGEN SPECIES (ROS), AND TOTAL ANTIOXIDANT CAPACITY (TAC), AND TELOMERE ATTRITION MARKERS TELOMERE LENGTH AND TELOMERASE ACTIVITY. THE SECONDARY ENDPOINTS WERE ASSESSMENT OF METABOTROPHIC BLOOD BIOMARKERS ASSOCIATED WITH CELLULAR AGING, WHICH INCLUDED CORTISOL, BETA-ENDORPHIN, IL-6, BDNF, AND SIRTUIN-1. AFTER 12 WEEKS OF YMLI, THERE WERE SIGNIFICANT IMPROVEMENTS IN BOTH THE CARDINAL BIOMARKERS OF CELLULAR AGING AND THE METABOTROPHIC BIOMARKERS INFLUENCING CELLULAR AGING COMPARED TO BASELINE VALUES. THE MEAN LEVELS OF 8-OH2DG, ROS, CORTISOL, AND IL-6 WERE SIGNIFICANTLY LOWER AND MEAN LEVELS OF TAC, TELOMERASE ACTIVITY, BETA-ENDORPHIN, BDNF, AND SIRTUIN-1 WERE SIGNIFICANTLY INCREASED (ALL VALUES P < 0.05) POST-YMLI. THE MEAN LEVEL OF TELOMERE LENGTH WAS INCREASED BUT THE FINDING WAS NOT SIGNIFICANT (P = 0.069). YMLI SIGNIFICANTLY REDUCED THE RATE OF CELLULAR AGING IN APPARENTLY HEALTHY POPULATION.	2017	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
3 1288  29 GREATER CORTICAL THICKNESS IN ELDERLY FEMALE YOGA PRACTITIONERS-A CROSS-SECTIONAL STUDY. YOGA, A MIND-BODY ACTIVITY THAT REQUIRES ATTENTIONAL ENGAGEMENT, HAS BEEN ASSOCIATED WITH POSITIVE CHANGES IN BRAIN STRUCTURE AND FUNCTION, ESPECIALLY IN AREAS RELATED TO AWARENESS, ATTENTION, EXECUTIVE FUNCTIONS AND MEMORY. NORMAL AGING, ON THE OTHER HAND, HAS ALSO BEEN ASSOCIATED WITH STRUCTURAL AND FUNCTIONAL BRAIN CHANGES, BUT THESE GENERALLY INVOLVE DECREASED COGNITIVE FUNCTIONS. THE AIM OF THIS CROSS-SECTIONAL STUDY WAS TO COMPARE BRAIN CORTICAL THICKNESS (CT) IN ELDERLY YOGA PRACTITIONERS AND A GROUP OF AGE-MATCHED HEALTHY NON-PRACTITIONERS. WE TESTED 21 OLDER WOMEN WHO HAD PRACTICED HATHA YOGA FOR AT LEAST 8 YEARS AND 21 WOMEN NAIVE TO YOGA, MEDITATION OR ANY MIND-BODY INTERVENTIONS WHO WERE MATCHED TO THE FIRST GROUP IN AGE, YEARS OF FORMAL EDUCATION AND PHYSICAL ACTIVITY LEVEL. A T1-WEIGHTED MPRAGE SEQUENCE WAS ACQUIRED FOR EACH PARTICIPANT. YOGA PRACTITIONERS SHOWED SIGNIFICANTLY GREATER CT IN A LEFT PREFRONTAL LOBE CLUSTER, WHICH INCLUDED PORTIONS OF THE LATERAL MIDDLE FRONTAL GYRUS, ANTERIOR SUPERIOR FRONTAL GYRUS AND DORSAL SUPERIOR FRONTAL GYRUS. WE FOUND GREATER CT IN THE LEFT PREFRONTAL CORTEX OF HEALTHY ELDERLY WOMEN WHO TRAINED YOGA FOR A MINIMUM OF 8 YEARS COMPARED WITH WOMEN IN THE CONTROL GROUP.	2017	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
4 2277  20 THE ROLES OF EXERCISE AND YOGA IN AMELIORATING DEPRESSION AS A RISK FACTOR FOR COGNITIVE DECLINE. CURRENTLY, THERE ARE NO EFFECTIVE PHARMACEUTICAL TREATMENTS TO REDUCE COGNITIVE DECLINE OR PREVENT DEMENTIA. AT THE SAME TIME, THE GLOBAL POPULATION IS AGING, AND RATES OF DEMENTIA AND MILD COGNITIVE IMPAIRMENT (MCI) ARE ON THE RISE. AS SUCH, THERE IS AN INCREASING INTEREST IN COMPLEMENTARY AND ALTERNATIVE INTERVENTIONS TO TREAT OR REDUCE THE RISK OF COGNITIVE DECLINE. DEPRESSION IS ONE POTENTIALLY MODIFIABLE RISK FACTOR FOR COGNITIVE DECLINE AND DEMENTIA. NOTABLY, EXERCISE AND YOGA ARE TWO INTERVENTIONS KNOWN TO BOTH REDUCE SYMPTOMS OF DEPRESSION AND IMPROVE COGNITIVE FUNCTION. THE CURRENT REVIEW DISCUSSES THE EFFICACY OF EXERCISE AND YOGA TO AMELIORATE DEPRESSION AND THEREBY REDUCE THE RISK OF COGNITIVE DECLINE AND POTENTIALLY PREVENT DEMENTIA. POTENTIAL MECHANISMS OF CHANGE, TREATMENT IMPLICATIONS, AND FUTURE DIRECTIONS ARE DISCUSSED.	2016	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
5   35  65 A 12-WEEK YOGA-BASED LIFESTYLE INTERVENTION MIGHT POSITIVELY MODIFY CELLULAR AGING IN INDIAN OBESE INDIVIDUALS: A RANDOMIZED-CONTROLLED TRIAL. BACKGROUND: TELOMERES AND TELOMERASE ARE CONSIDERED CARDINAL BIOMARKERS OF CELLULAR AGING. SHORTER TELOMERES AND LOW TELOMERASE ACTIVITY HAVE BEEN ASSOCIATED WITH OBESITY AND ACCELERATED AGING. OBJECTIVE: TO COMPARE THE EFFECTS OF A YOGA-BASED LIFESTYLE INTERVENTION (YBLI) WITH THE STANDARD OF CARE (SOC) ON CELLULAR AGING BY ESTIMATING TELOMERE LENGTH (TL) AND TELOMERASE ACTIVITY IN OBESITY. DESIGN AND SETTING: A PARALLEL, TWO-ARM, RANDOMIZED-CONTROLLED TRIAL WAS CONDUCTED AT THE INTEGRAL HEALTH CLINIC, DEPARTMENT OF PHYSIOLOGY, ALL INDIA INSTITUTE OF MEDICAL SCIENCES, NEW DELHI, FROM MARCH 2017 TO OCTOBER 2019. PARTICIPANTS: OBESE (N = 72), BODY MASS INDEX (BMI), 25-35 KG/M(2), AGED 20-45 YEARS, MALE (21), AND FEMALE (51). INTERVENTION: SEVENTY-TWO OBESE PARTICIPANTS WERE RANDOMIZED TO RECEIVE EITHER A 12-WEEK SOC (N = 36) OR YBLI (N = 36). SOC INCLUDED MANAGEMENT OF OBESITY AS PER INDIAN GUIDELINES INCLUDING A HYPOCALORIC INDIVIDUALIZED DIET AND PHYSICAL ACTIVITY. THE PRETESTED YBLI INCLUDED ASANA (PHYSICAL POSTURES), PRANAYAMA (BREATHING EXERCISES), AND MEDITATION. METHODS: BLOOD SAMPLES WERE COLLECTED FROM BOTH THE GROUPS AT BASELINE, 2, 4, AND 12 WEEKS. DNA WAS EXTRACTED FROM PERIPHERAL BLOOD MONONUCLEAR CELLS. TL WAS MEASURED BY QUANTITATIVE PCR, AND SERUM TELOMERASE LEVELS BY IMMUNOASSAY. OUTCOME MEASURES: PRIMARY OUTCOME MEASURES WERE THE CHANGES IN THE TL AND TELOMERASE LEVELS BETWEEN THE TWO GROUPS AT WEEK 12. SECONDARY OUTCOME MEASURES WERE THE CHANGES IN TL AND TELOMERASE, AND ANTHROPOMETRIC PARAMETERS (BODY WEIGHT, BMI, WAIST-TO-HIP RATIO) AT 2, 4, AND 12 WEEKS OF INTERVENTION IN BOTH SOC AND YBLI GROUPS. RESULTS: THERE WERE NO SIGNIFICANT CHANGES IN TL AND TELOMERASE LEVELS BETWEEN THE GROUPS AT WEEK 12. THE TL WAS SIGNIFICANTLY GREATER IN THE YBLI GROUP VERSUS THE SOC GROUP (P < 0.0001) AT 2 WEEKS. THE ANTHROPOMETRIC AND PHYSIOLOGICAL PARAMETERS WERE INFLUENCED POSITIVELY BY BOTH SOC AND YBLI. CONCLUSION: THE STUDY DID NOT MEET THE PRIMARY OBJECTIVE, ALTHOUGH THE RESULTS ARE SUGGESTIVE OF A POSITIVE IMPACT OF YBLI ON AGING IN OBESITY AS NOTED WITHIN THE YBLI GROUP. HOWEVER, THE RESULTS SHOULD BE INTERPRETED CAREFULLY, AND IN THE LIGHT OF OTHER PUBLISHED DATA. LARGER STUDIES TO BETTER UNDERSTAND THE POSSIBLE POSITIVE BENEFITS OF YBLI ON CELLULAR AGING ARE RECOMMENDED. CLINICAL TRAIL REGISTRATION NO. CTRI/2016/08/007136.	2022	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
6  455  26 CHANGES IN NEURAL CONNECTIVITY AND MEMORY FOLLOWING A YOGA INTERVENTION FOR OLDER ADULTS: A PILOT STUDY. BACKGROUND: NO STUDY HAS EXPLORED THE EFFECT OF YOGA ON COGNITIVE DECLINE AND RESTING-STATE FUNCTIONAL CONNECTIVITY. OBJECTIVES: THIS STUDY EXPLORED THE RELATIONSHIP BETWEEN PERFORMANCE ON MEMORY TESTS AND RESTING-STATE FUNCTIONAL CONNECTIVITY BEFORE AND AFTER A YOGA INTERVENTION VERSUS ACTIVE CONTROL FOR SUBJECTS WITH MILD COGNITIVE IMPAIRMENT (MCI). METHODS: PARTICIPANTS ( >/= 55 Y) WITH MCI WERE RANDOMIZED TO RECEIVE A YOGA INTERVENTION OR ACTIVE "GOLD-STANDARD" CONTROL (I.E., MEMORY ENHANCEMENT TRAINING (MET)) FOR 12 WEEKS. RESTING-STATE FUNCTIONAL MAGNETIC RESONANCE IMAGING WAS USED TO MAP CORRELATIONS BETWEEN BRAIN NETWORKS AND MEMORY PERFORMANCE CHANGES OVER TIME. DEFAULT MODE NETWORKS (DMN), LANGUAGE AND SUPERIOR PARIETAL NETWORKS WERE CHOSEN AS NETWORKS OF INTEREST TO ANALYZE THE ASSOCIATION WITH CHANGES IN VERBAL AND VISUOSPATIAL MEMORY PERFORMANCE. RESULTS: FOURTEEN YOGA AND 11 MET PARTICIPANTS COMPLETED THE STUDY. THE YOGA GROUP DEMONSTRATED A STATISTICALLY SIGNIFICANT IMPROVEMENT IN DEPRESSION AND VISUOSPATIAL MEMORY. WE OBSERVED IMPROVED VERBAL MEMORY PERFORMANCE CORRELATED WITH INCREASED CONNECTIVITY BETWEEN THE DMN AND FRONTAL MEDIAL CORTEX, PREGENUAL ANTERIOR CINGULATE CORTEX, RIGHT MIDDLE FRONTAL CORTEX, POSTERIOR CINGULATE CORTEX, AND LEFT LATERAL OCCIPITAL CORTEX. IMPROVED VERBAL MEMORY PERFORMANCE POSITIVELY CORRELATED WITH INCREASED CONNECTIVITY BETWEEN THE LANGUAGE PROCESSING NETWORK AND THE LEFT INFERIOR FRONTAL GYRUS. IMPROVED VISUOSPATIAL MEMORY PERFORMANCE CORRELATED INVERSELY WITH CONNECTIVITY BETWEEN THE SUPERIOR PARIETAL NETWORK AND THE MEDIAL PARIETAL CORTEX. CONCLUSION: YOGA MAY BE AS EFFECTIVE AS MET IN IMPROVING FUNCTIONAL CONNECTIVITY IN RELATION TO VERBAL MEMORY PERFORMANCE. THESE FINDINGS SHOULD BE CONFIRMED IN LARGER PROSPECTIVE STUDIES.	2016	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
7 1266  19 FLUID INTELLIGENCE AND BRAIN FUNCTIONAL ORGANIZATION IN AGING YOGA AND MEDITATION PRACTITIONERS. NUMEROUS STUDIES HAVE DOCUMENTED THE NORMAL AGE-RELATED DECLINE OF NEURAL STRUCTURE, FUNCTION, AND COGNITIVE PERFORMANCE. PRELIMINARY EVIDENCE SUGGESTS THAT MEDITATION MAY REDUCE DECLINE IN SPECIFIC COGNITIVE DOMAINS AND IN BRAIN STRUCTURE. HERE WE EXTENDED THIS RESEARCH BY INVESTIGATING THE RELATION BETWEEN AGE AND FLUID INTELLIGENCE AND RESTING STATE BRAIN FUNCTIONAL NETWORK ARCHITECTURE USING GRAPH THEORY, IN MIDDLE-AGED YOGA AND MEDITATION PRACTITIONERS, AND MATCHED CONTROLS. FLUID INTELLIGENCE DECLINED SLOWER IN YOGA PRACTITIONERS AND MEDITATORS COMBINED THAN IN CONTROLS. RESTING STATE FUNCTIONAL NETWORKS OF YOGA PRACTITIONERS AND MEDITATORS COMBINED WERE MORE INTEGRATED AND MORE RESILIENT TO DAMAGE THAN THOSE OF CONTROLS. FURTHERMORE, MINDFULNESS WAS POSITIVELY CORRELATED WITH FLUID INTELLIGENCE, RESILIENCE, AND GLOBAL NETWORK EFFICIENCY. THESE FINDINGS REVEAL THE POSSIBILITY TO INCREASE RESILIENCE AND TO SLOW THE DECLINE OF FLUID INTELLIGENCE AND BRAIN FUNCTIONAL ARCHITECTURE AND SUGGEST THAT MINDFULNESS PLAYS A MECHANISTIC ROLE IN THIS PRESERVATION.	2014	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
8  888  47 EFFECT OF YOGA VERSUS LIGHT EXERCISE TO IMPROVE WELL-BEING AND PROMOTE HEALTHY AGING AMONG OLDER ADULTS IN CENTRAL INDIA: A STUDY PROTOCOL FOR A RANDOMIZED CONTROLLED TRIAL. BACKGROUND: AGING IS A NATURAL PROCESS ASSOCIATED WITH MANY FUNCTIONAL AND STRUCTURAL CHANGES. THESE CHANGES MAY INCLUDE IMPAIRED SELF-REGULATION, CHANGES IN TISSUES AND ORGANS. AGING ALSO AFFECTS MOOD, PHYSICAL STATUS AND SOCIAL ACTIVITY. THERE ARE ADVERSE CHANGES IN COGNITIVE BEHAVIOR, PERCEIVED SENSATION AND THINKING PROCESSES. REGULAR PHYSICAL ACTIVITY CAN ALLEVIATE MANY HEALTH PROBLEMS; YET, MANY OLDER ADULTS ARE INACTIVE. YOGA IS ONE OF THE SCIENTIFIC AND POPULAR LIFESTYLE PRACTICE CONSIDERED AS THE INTEGRATION OF MIND, BODY AND SOUL. RESULTS OF PREVIOUS STUDIES REPORTED POSITIVE EFFECTS OF YOGA ON MULTIPLE HEALTH OUTCOMES IN ELDERLY. HOWEVER, THERE IS SCARCITY OF SCIENTIFIC INFORMATION WHERE YOGA'S EFFECT IS EXAMINED ON OVER WELL-BEING AND ON MULTIPLE HEALTH OUTCOMES SIMULTANEOUSLY IN ELDERLY. THIS PROTOCOL DESCRIBES METHODS FOR A 12-WEEK YOGA-BASED INTERVENTION EXPLORING THE EFFECTS OF YOGA ON WELL-BEING IN PHYSICALLY INACTIVE ELDERLY LIVING IN COMMUNITY. METHODS AND ANALYSIS: THIS TWO GROUP PARALLEL SINGLE BLIND RANDOMIZED CONTROLLED TRIAL THAT WILL BE CONDUCTED AT A DESIGNATED FACILITY OF R.D. GARDI MEDICAL COLLEGE, UJJAIN, MADHYA PRADESH, CENTRAL INDIA. A 12-WEEK 60-MIN YOGA INTERVENTION THREE TIMES WEEKLY IS DESIGNED. COMPARISON GROUP PARTICIPANTS WILL UNDERGO A 60-MIN PROGRAM COMPRISING LIGHT EXERCISE FOCUSING ON CONVENTIONAL STRETCHING TO IMPROVE MOBILITY. AFTER SCREENING, 144 PARTICIPANTS AGED 60-80 YEARS WILL BE RECRUITED. THE PRIMARY OUTCOME IS SUBJECTIVE WELL-BEING. SECONDARY OUTCOMES INCLUDE MOBILITY, FALL RISK, COGNITION, ANXIETY AND DEPRESSION, MOOD AND STRESS, SLEEP QUALITY, PAIN, PHYSICAL ACTIVITY/SEDENTARY BEHAVIOR AND CARDIO-METABOLIC RISK FACTORS. ASSESSMENTS WILL BE CONDUCTED AT BASELINE (0 WEEK), AFTER THE INTERVENTION (12+1 WEEK) AND AT FOLLOW-UP (36+1 WEEK). INTENTION-TO-TREAT ANALYSES WITH MIXED LINEAR MODELING WILL BE APPLIED. DISCUSSION: THROUGH THIS TRIAL, WE AIM TO DETERMINE WHETHER ELDERLY PEOPLE IN THE INTERVENTION GROUP PRACTICING YOGA SHOW MORE FAVORABLE PRIMARY (WELL-BEING) AND SECONDARY OUTCOMES THAN THOSE IN THE LIGHT EXERCISE FOCUSING ON CONVENTIONAL STRETCHING GROUP. WE ASSUME THAT YOGA MAY BE PRACTICED TO MAINTAIN HEALTH, REDUCE PARTICULAR SYMPTOMS COMMONLY ASSOCIATED WITH SKELETAL PAIN, ASSIST IN PAIN RELIEF AND ENHANCE WELL-BEING. WE ANTICIPATE THAT PRACTICING YOGA WILL IMPROVE WELL-BEING AND MENTAL HEALTH AND MAY LEAD TO SIGNIFICANT IMPROVEMENT IN DEPRESSION, PAIN AND SLEEP QUALITY.ETHICS AND DISSEMINATION: THIS STUDY IS APPROVED BY THE INSTITUTIONAL ETHICS COMMITTEE OF R.D. GARDI MEDICAL COLLEGE, UJJAIN, IEC REF NO. 09/2018. ALL PARTICIPANTS WOULD BE PROVIDED WITH WRITTEN AND VERBAL INFORMATION ABOUT THE PURPOSE OF THE PROJECT AND WOULD BE FREE TO WITHDRAW FROM THE STUDY AT ANY TIME. REFUSAL TO PARTICIPATE IN THE STUDY WOULD NOT HAVE ANY NEGATIVE CONSEQUENCES. CONFIDENTIALITY OF THE INFORMATION OF EACH PARTICIPANT WOULD BE ENSURED. KNOWLEDGE OBTAINED WOULD BE DISSEMINATED TO STAKEHOLDERS THROUGH WORKSHOPS, MEETINGS AND RELEVANT SCIENTIFIC CONFERENCES. TRIAL REGISTRATION: THE TRIAL IS PROSPECTIVELY REGISTERED WITH THE INDIAN COUNCIL OF MEDICAL RESEARCH TRIAL REGISTRY CTRI/2018/07/015051.	2019	

9 1051  31 EFFECTS OF YOGA ON BRAIN WAVES AND STRUCTURAL ACTIVATION: A REVIEW. PREVIOUS RESEARCH HAS SHOWN THE VAST MENTAL AND PHYSICAL HEALTH BENEFITS ASSOCIATED WITH YOGA. YOGA PRACTICE CAN BE DIVIDED INTO SUBCATEGORIES THAT INCLUDE POSTURE-HOLDING EXERCISE (ASANA), BREATHING (PRANAYAMA, KRIYA), AND MEDITATION (SAHAJ) PRACTICE. STUDIES MEASURING MENTAL HEALTH OUTCOMES HAVE SHOWN DECREASES IN ANXIETY, AND INCREASES IN COGNITIVE PERFORMANCE AFTER YOGA INTERVENTIONS. SIMILAR STUDIES HAVE ALSO SHOWN COGNITIVE ADVANTAGES AMONGST YOGA PRACTITIONERS VERSUS NON-PRACTITIONERS. THE MENTAL HEALTH AND COGNITIVE BENEFITS OF YOGA ARE EVIDENT, BUT THE PHYSIOLOGICAL AND STRUCTURAL CHANGES IN THE BRAIN THAT LEAD TO THIS REMAIN A TOPIC THAT LACKS CONSENSUS. THEREFORE, THE PURPOSE OF THIS STUDY WAS TO EXAMINE AND REVIEW EXISTING LITERATURE ON THE EFFECTS OF YOGA ON BRAIN WAVES AND STRUCTURAL CHANGES AND ACTIVATION. AFTER A NARROWED SEARCH THROUGH A SET OF SPECIFIC INCLUSION AND EXCLUSION CRITERIA, 15 ARTICLES WERE USED IN THIS REVIEW. IT WAS CONCLUDED THAT BREATHING, MEDITATION, AND POSTURE-BASED YOGA INCREASED OVERALL BRAIN WAVE ACTIVITY. INCREASES IN GRAYGRAY MATTER ALONG WITH INCREASES IN AMYGDALA AND FRONTAL CORTEX ACTIVATION WERE EVIDENT AFTER A YOGA INTERVENTION. YOGA PRACTICE MAY BE AN EFFECTIVE ADJUNCTIVE TREATMENT FOR A CLINICAL AND HEALTHY AGING POPULATION. FURTHER RESEARCH CAN EXAMINE THE EFFECTS OF SPECIFIC BRANCHES OF YOGA ON A DESIGNATED CLINICAL POPULATION.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
10  626  24 DIFFERENCE IN MUSCLE ACTIVATION PATTERNS DURING HIGH-SPEED VERSUS STANDARD-SPEED YOGA: A RANDOMIZED SEQUENCE CROSSOVER STUDY. OBJECTIVES: TO COMPARE THE DIFFERENCE IN MUSCLE ACTIVATION BETWEEN HIGH-SPEED YOGA AND STANDARD-SPEED YOGA AND TO COMPARE MUSCLE ACTIVATION OF THE TRANSITIONS BETWEEN POSES AND THE HELD PHASES OF A YOGA POSE. DESIGN: RANDOMIZED SEQUENCE CROSSOVER TRIAL SETTING: A LABORATORY OF NEUROMUSCULAR RESEARCH AND ACTIVE AGING INTERVENTIONS: EIGHT MINUTES OF CONTINUOUS SUN SALUTATION B WAS PERFORMED, AT A HIGH SPEED VERSUS A STANDARD-SPEED, SEPARATELY. ELECTROMYOGRAPHY WAS USED TO QUANTIFY NORMALIZED MUSCLE ACTIVATION PATTERNS OF EIGHT UPPER AND LOWER BODY MUSCLES (PECTORALIS MAJOR, MEDIAL DELTOIDS, LATERAL HEAD OF THE TRICEPS, MIDDLE FIBERS OF THE TRAPEZIUS, VASTUS MEDIALIS, MEDIAL GASTROCNEMIUS, THORACIC EXTENSOR SPINAE, AND EXTERNAL OBLIQUES) DURING THE HIGH-SPEED AND STANDARD-SPEED YOGA PROTOCOLS. MAIN OUTCOME MEASURES: DIFFERENCE IN NORMALIZED MUSCLE ACTIVATION BETWEEN HIGH-SPEED YOGA AND STANDARD-SPEED YOGA. RESULTS: NORMALIZED MUSCLE ACTIVITY SIGNALS WERE SIGNIFICANTLY HIGHER IN ALL EIGHT MUSCLES DURING THE TRANSITION PHASES OF POSES COMPARED TO THE HELD PHASES (P<0.01). THERE WAS NO SIGNIFICANT INTERACTION BETWEEN SPEEDXPHASE; HOWEVER, GREATER NORMALIZED MUSCLE ACTIVITY WAS SEEN FOR HIGHSPEED YOGA ACROSS THE ENTIRE SESSION. CONCLUSIONS: OUR RESULTS SHOW THAT TRANSITIONS FROM ONE HELD PHASE OF A POSE TO ANOTHER PRODUCES HIGHER NORMALIZED MUSCLE ACTIVITY THAN THE HELD PHASES OF THE POSES AND THAT OVERALL ACTIVITY IS GREATER DURING HIGHSPEED YOGA THAN STANDARD-SPEED YOGA. THEREFORE, THE TRANSITION SPEED AND ASSOCIATED NUMBER OF POSES SHOULD BE CONSIDERED WHEN TARGETING SPECIFIC IMPROVEMENTS IN PERFORMANCE.	2017	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
11 2179  22 THE EFFECTS OF YOGA ON PATIENTS WITH MILD COGNITIVE IMPAIRMENT AND DEMENTIA: A SCOPING REVIEW. YOGA IS AN ANCIENT MIND BODY PRACTICE. ALTHOUGH YOGA HAS BEEN USED AS A COMPLEMENTARY HEALTH APPROACH FOR ENHANCING WELLNESS AND ADDRESSING A VARIETY OF HEALTH ISSUES, LITTLE IS KNOWN ABOUT THE IMPACT OF YOGA ON COGNITIVE FUNCTIONING IN ADULTS WITH MILD COGNITIVE IMPAIRMENT (MCI) AND DEMENTIA. WE CONDUCTED A LITERATURE REVIEW TO EXAMINE THE IMPACT OF YOGA ON PERSONS WITH MCI AND DEMENTIA. EIGHT STUDIES WERE IDENTIFIED THAT REPORTED ON YOGA AS EITHER THE PRIMARY INTERVENTION OR ONE COMPONENT OF A MULTI-COMPONENT INTERVENTION IN SAMPLES OF PERSONS WITH MCI OR DEMENTIA. RESULTS SUGGEST THAT YOGA MAY HAVE BENEFICIAL EFFECTS ON COGNITIVE FUNCTIONING, PARTICULARLY ON ATTENTION AND VERBAL MEMORY. FURTHER, YOGA MAY AFFECT COGNITIVE FUNCTIONING THROUGH IMPROVED SLEEP, MOOD, AND NEURAL CONNECTIVITY. THERE ARE A NUMBER OF LIMITATIONS OF THE EXISTING STUDIES, INCLUDING A LACK OF INTERVENTION DETAILS, AS WELL AS VARIABILITY IN THE FREQUENCY/DURATION AND COMPONENTS OF THE YOGA INTERVENTIONS. A FURTHER COMPLICATING ISSUE IS THE ROLE OF VARIOUS UNDERLYING ETIOLOGIES OF COGNITIVE IMPAIRMENT. DESPITE THESE LIMITATIONS, PROVIDERS MAY CONSIDER RECOMMENDING YOGA TO PERSONS WITH MCI OR DEMENTIA AS A SAFE AND POTENTIALLY BENEFICIAL COMPLEMENTARY HEALTH APPROACH.	2019	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
12  629  27 DIFFERENCES IN BRAIN STRUCTURE AND FUNCTION AMONG YOGA PRACTITIONERS AND CONTROLS. BACKGROUND: YOGA IS A MIND-BODY BASED PHYSICAL ACTIVITY THAT HAS DEMONSTRATED A VARIETY OF PHYSIOLOGICAL, PSYCHOLOGICAL AND COGNITIVE HEALTH BENEFITS. ALTHOUGH YOGA PRACTICE HAS SHOWN TO IMPROVE COGNITIVE PERFORMANCE, FEW STUDIES HAVE EXAMINED THE UNDERLYING NEUROLOGICAL CORRELATES. OBJECTIVE: THE CURRENT STUDY AIMED TO DETERMINE THE DIFFERENCES IN GRAY MATTER VOLUME OF THE HIPPOCAMPUS, THALAMUS AND CAUDATE NUCLEUS AND BRAIN ACTIVATION DURING THE STERNBERG WORKING MEMORY TASK. METHOD: PARTICIPANTS WERE 13 EXPERIENCED YOGA PRACTITIONERS (MEAN AGE = 35.8), DEFINED AS HAVING MORE THAN 3 YEARS OF REGULAR YOGA PRACTICE, AND 13 AGE- AND SEX-MATCHED CONTROLS (MEAN AGE = 35.7). ALL PARTICIPANTS COMPLETED A 6-MIN WALK TEST TO ASSESS FITNESS, PSYCHOSOCIAL AND DEMOGRAPHIC QUESTIONNAIRES; AND UNDERWENT MAGNETIC RESONANCE IMAGING TO ASSESS GRAY MATTER VOLUME AND BRAIN ACTIVATION. RESULTS: THERE WERE NO GROUP DIFFERENCES ON DEMOGRAPHIC MEASURES OF INCOME, EDUCATION AND ON ESTIMATED VO2MAX OR PHYSICAL ACTIVITY LEVELS. GRAY MATTER VOLUME DIFFERENCES WERE OBSERVED IN THE LEFT HIPPOCAMPUS, SHOWING GREATER VOLUME IN EXPERIENCED YOGA PRACTITIONERS COMPARED TO CONTROLS (P = 0.017). THE FUNCTIONAL MRI RESULTS REVEALED LESS ACTIVATION IN THE DORSOLATERAL PREFRONTAL CORTEX IN YOGA PRACTITIONERS COMPARED TO CONTROLS DURING THE ENCODING PHASE OF THE STERNBERG TASK (P < 0.05). REACTION TIME AND ACCURACY ON THE TASK DID NOT DIFFER BETWEEN THE GROUPS. CONCLUSIONS: OUR RESULTS SUGGEST AN ASSOCIATION BETWEEN REGULAR LONG-TERM YOGA PRACTICE AND DIFFERENTIAL STRUCTURE AND FUNCTION OF SPECIFIC BRAIN REGIONS INVOLVED IN EXECUTIVE FUNCTION, SPECIFICALLY WORKING MEMORY, WHICH HAS PREVIOUSLY SHOWN TO IMPROVE WITH YOGA PRACTICE. FUTURE STUDIES NEED TO EXAMINE INTERVENTION EFFECTS OF YOGA AND EXPLORE ITS POTENTIAL TO MAINTAIN AND IMPROVE COGNITIVE HEALTH ACROSS THE LIFESPAN THROUGH LONGITUDINAL AND INTERVENTION STUDIES.	2018	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
13 2588  37 YOGA FOR IMPROVING SLEEP QUALITY AND QUALITY OF LIFE FOR OLDER ADULTS. CONTEXT: THE AGING PROCESS IS ASSOCIATED WITH PHYSIOLOGICAL CHANGES THAT AFFECT SLEEP. IN OLDER ADULTS, UNDIAGNOSED AND UNTREATED INSOMNIA MAY CAUSE IMPAIRED DAILY FUNCTION AND REDUCED QUALITY OF LIFE (QOL). INSOMNIA IS ALSO A RISK FACTOR FOR ACCIDENTS AND FALLS THAT ARE THE MAIN CAUSE OF ACCIDENTAL DEATHS IN OLDER ADULTS AND, THEREFORE, IS ASSOCIATED WITH HIGHER MORBIDITY AND MORTALITY RATES IN OLDER POPULATIONS. OBJECTIVES: THE RESEARCH TEAM AIMED TO (1) EXAMINE THE EFFICACY OF A YOGA INTERVENTION (YI) FOR THE TREATMENT OF INSOMNIA IN OLDER ADULTS, (2) DETERMINE THE ABILITY OF YOGA TO ENHANCE THE QOL OF OLDER ADULTS, AND (3) ESTABLISH THE APPLICABILITY OF YOGA PRACTICE FOR OLDER PEOPLE IN A WESTERN CULTURAL SETTING. DESIGN: A WAITING-LIST CONTROLLED TRIAL. SETTINGS * THE STUDY TOOK PLACE IN JERUSALEM, ISRAEL, FROM 2008-2009. PARTICIPANTS: PARTICIPANTS WERE OLDER MEN AND WOMEN (AGE >/= 60 Y) WITH INSOMNIA. INTERVENTION: THE YI GROUP PARTICIPATED IN 12 WK OF CLASSES, HELD 2 X/WK, INCORPORATING YOGA POSTURES, MEDITATIVE YOGA, AND DAILY HOME PRACTICE OF MEDITATIVE YOGA. OUTCOME MEASURES: THE STUDY USED SELF-REPORT ASSESSMENTS OF SLEEP QUALITY USING THE FOLLOWING: (1) SLEEP QUALITY-THE KAROLINSKA SLEEPINESS SCALE (KSS), THE EPWORTH SLEEPINESS SCALE (ESS), AND THE PITTSBURGH SLEEP QUALITY INDEX (PSQI), AND DAILY SLEEP AND PRACTICE LOGS; (2) MOOD STATES-THE DEPRESSION ANXIETY STRESS SCALE LONG FORM (DASS-42) AND THE PROFILE OF MOOD STATES SHORT FORM (POMS-SF); (3) A HEALTH SURVEY (SF-36); AND (4) MOBILE AT-HOME SLEEP STUDIES. RESULTS: COMPARED WITH CONTROLS, THE YI GROUP SHOWED SIGNIFICANT IMPROVEMENTS IN A RANGE OF SUBJECTIVE FACTORS, INCLUDING OVERALL SLEEP QUALITY; SLEEP EFFICIENCY; SLEEP LATENCY AND DURATION; SELF-ASSESSED SLEEP QUALITY; FATIGUE; GENERAL WELL-BEING; DEPRESSION; ANXIETY; STRESS; TENSION; ANGER; VITALITY; AND FUNCTION IN PHYSICAL, EMOTIONAL, AND SOCIAL ROLES. CONCLUSIONS: YOGA WAS SHOWN TO BE SAFE AND IMPROVED SLEEP AND QOL IN A GROUP OF OLDER ADULTS WITH INSOMNIA. OUTCOMES DEPENDED ON PRACTICE COMPLIANCE.	2014	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
14 1204  27 EXPERIENCE OF ELDERLY PEOPLE REGARDING THE EFFECT OF YOGA/LIGHT EXERCISE ON SEDENTARY BEHAVIOR: A LONGITUDINAL QUALITATIVE STUDY IN MADHYA PRADESH, INDIA. THIS STUDY IS SET ON THE BACKGROUND OF A RANDOMIZED CONTROL TRIAL (RCT) IN WHICH INTERVENTION WAS CARRIED TO OBSERVE THE EFFECTS OF YOGA/LIGHT EXERCISE ON THE IMPROVEMENT IN HEALTH AND WELL-BEING AMONG THE ELDERLY POPULATION. A LONGITUDINAL QUALITATIVE STUDY WAS CONDUCTED AS PART OF RCT INTERVENTIONS TO EXPLORE THE EXPERIENCE OF THE ELDERLY PRACTICING YOGA/LIGHT EXERCISE IN RELATION TO SEDENTARY BEHAVIOR IN THE UJJAIN DISTRICT OF MADHYA PRADESH, INDIA. PARTICIPANTS OF THE RCT WERE SELECTED FOR THIS STUDY. EIGHTEEN FOCUS GROUP DISCUSSIONS WERE CONDUCTED-SIX DURING EACH PHASE OF RCT INTERVENTIONS (BEFORE, DURING, AND AFTER). THE FINDINGS REGARDING MOTIVATING AND DEMOTIVATING FACTORS IN VARIOUS PHASES OF INTERVENTION WERE PRESENTED IN THREE CATEGORIES: EXPERIENCE AND PERCEPTION OF THE EFFECTS OF YOGA/LIGHT EXERCISE ON SEDENTARY BEHAVIOR (1) BEFORE, (2) DURING, AND (3) AFTER INTERVENTION. THIS STUDY EXPLORES THE POSITIVE EFFECT OF YOGA/LIGHT EXERCISE ON SEDENTARY BEHAVIOR AND SUBJECTIVE WELL-BEING ON THE ELDERLY POPULATION. THEY WERE RECOGNIZED TO HAVE UNDERGONE CHANGES IN THEIR PHYSICAL AND EMOTIONAL WELL-BEING BY CONSISTENTLY PRACTICING YOGA/LIGHT EXERCISE. THE MAIN DRIVING FACTORS WERE PERIODIC HEALTH CHECK-UPS AND THE ENCOURAGEMENT OF QUALIFIED TRAINERS WITHOUT ANY COST. THIS STUDY CONCLUDES WITH THE NOTION THAT THESE INTERVENTIONS SHOULD BE ENCOURAGED IN THE COMMUNITY TO USE PHYSICAL EXERCISE AS A METHOD TO BETTER CONTROL THE PHYSICAL AND SOCIAL EFFECTS OF AGING.	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
15  176  26 A RANDOMIZED CONTROLLED TRIAL OF KUNDALINI YOGA IN MILD COGNITIVE IMPAIRMENT. BACKGROUND: GLOBAL POPULATION AGING WILL RESULT IN INCREASING RATES OF COGNITIVE DECLINE AND DEMENTIA. THUS, EFFECTIVE, LOW-COST, AND LOW SIDE-EFFECT INTERVENTIONS FOR THE TREATMENT AND PREVENTION OF COGNITIVE DECLINE ARE URGENTLY NEEDED. OUR STUDY IS THE FIRST TO INVESTIGATE THE EFFECTS OF KUNDALINI YOGA (KY) TRAINING ON MILD COGNITIVE IMPAIRMENT (MCI). METHODS: OLDER PARTICIPANTS (>/=55 YEARS OF AGE) WITH MCI WERE RANDOMIZED TO EITHER A 12-WEEK KY INTERVENTION OR MEMORY ENHANCEMENT TRAINING (MET; GOLD-STANDARD, ACTIVE CONTROL). COGNITIVE (I.E. MEMORY AND EXECUTIVE FUNCTIONING) AND MOOD (I.E. DEPRESSION, APATHY, AND RESILIENCE) ASSESSMENTS WERE ADMINISTERED AT BASELINE, 12 WEEKS AND 24 WEEKS. RESULTS: AT BASELINE, 81 PARTICIPANTS HAD NO SIGNIFICANT BASELINE GROUP DIFFERENCES IN CLINICAL OR DEMOGRAPHIC CHARACTERISTICS. AT 12 WEEKS AND 24 WEEKS, BOTH KY AND MET GROUPS SHOWED SIGNIFICANT IMPROVEMENT IN MEMORY; HOWEVER, ONLY KY SHOWED SIGNIFICANT IMPROVEMENT IN EXECUTIVE FUNCTIONING. ONLY THE KY GROUP SHOWED SIGNIFICANT IMPROVEMENT IN DEPRESSIVE SYMPTOMS AND RESILIENCE AT WEEK 12. CONCLUSION: KY GROUP SHOWED SHORT- AND LONG-TERM IMPROVEMENTS IN EXECUTIVE FUNCTIONING AS COMPARED TO MET, AND BROADER EFFECTS ON DEPRESSED MOOD AND RESILIENCE. THIS OBSERVATION SHOULD BE CONFIRMED IN FUTURE CLINICAL TRIALS OF YOGA INTERVENTION FOR TREATMENT AND PREVENTION OF COGNITIVE DECLINE (NCT01983930).	2017	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
16 2217  28 THE IMPACT OF A SHORT-TERM IYENGAR YOGA PROGRAM ON THE HEALTH AND WELL-BEING OF PHYSICALLY INACTIVE OLDER ADULTS. BACKGROUND: WITH THE CURRENT CHALLENGE OF RAPIDLY AGING POPULATIONS, PRACTICES SUCH AS YOGA MAY HELP OLDER ADULTS STAY PHYSICALLY ACTIVE, HEALTHY, AND FULFILLED. METHODS: THE IMPACT OF AN 8-WEEK IYENGAR YOGA PROGRAM ON THE HOLISTIC HEALTH AND WELL-BEING OF PHYSICALLY INACTIVE PEOPLE AGED 55 YEARS AND OVER WAS ASSESSED. THIRTY-EIGHT OLDER ADULTS (MEAN AGE 73.21+/-8.38 YEARS; 19 INTERVENTION, 19 CONTROL) ENGAGED IN EITHER TWICE-WEEKLY YOGA CLASSES OR CONTINUED THEIR USUAL DAILY ROUTINES. PHYSICAL HEALTH MEASURES WERE MUSCLE STRENGTH, ACTIVE RANGE OF MOTION, RESPIRATORY FUNCTION (FEV1), RESTING BLOOD PRESSURE, AND IMMUNE FUNCTION (SALIVARY IGA AND LYSOZYME). SELF-PERCEIVED GENERAL, PHYSICAL, MENTAL, SPIRITUAL, AND SOCIAL HEALTH AND WELL-BEING WERE ASSESSED WITH THE LIFE'S ODYSSEY QUESTIONNAIRE AND THE SF12V2 HEALTH SURVEY. RESULTS: MUSCLE STRENGTH, ACTIVE RANGE OF MOTION, PHYSICAL WELL-BEING, AND ASPECTS OF MENTAL WELL-BEING (EMOTIONAL WELL-BEING AND SELF-CARE) IMPROVED SIGNIFICANTLY IN THE YOGA GROUP (P<.05). MEDIAN CHANGES IN MOST OF THESE VARIABLES WERE ALSO SIGNIFICANTLY DIFFERENT FROM THOSE IN THE CONTROL GROUP. CONCLUSIONS: PARTICIPATION IN IYENGAR YOGA PROGRAMS BY OLDER PEOPLE IS BENEFICIAL FOR HEALTH AND WELL-BEING, AND GREATER AVAILABILITY OF SUCH PROGRAMS COULD IMPROVE QUALITY OF LIFE.	2011	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
17 1098  34 EFFECTS OF YOGA RESPIRATORY PRACTICE (BHASTRIKA PRANAYAMA) ON ANXIETY, AFFECT, AND BRAIN FUNCTIONAL CONNECTIVITY AND ACTIVITY: A RANDOMIZED CONTROLLED TRIAL. PRANAYAMA REFERS TO A SET OF YOGA BREATHING EXERCISES. RECENT EVIDENCE SUGGESTS THAT THE PRACTICE OF PRANAYAMA HAS POSITIVE EFFECTS ON MEASURES OF CLINICAL STRESS AND ANXIETY. THIS STUDY EXPLORED THE IMPACT OF A BHASTRIKA PRANAYAMA TRAINING PROGRAM ON EMOTION PROCESSING, ANXIETY, AND AFFECT. WE USED A RANDOMIZED CONTROLLED TRIAL DESIGN WITH THIRTY HEALTHY YOUNG ADULTS ASSESSED AT BASELINE AND AFTER 4 WEEKS OF PRANAYAMA PRACTICES. TWO FUNCTIONAL MAGNETIC RESONANCE IMAGING (MRI) PROTOCOLS WERE USED BOTH AT BASELINE AND POST-INTERVENTION: AN EMOTION TASK AS WELL AS A RESTING-STATE ACQUISITION. OUR RESULTS SUGGEST THAT PRANAYAMA SIGNIFICANTLY DECREASED STATES OF ANXIETY AND NEGATIVE AFFECT. THE PRACTICE OF PRANAYAMA ALSO MODULATED THE ACTIVITY OF BRAIN REGIONS INVOLVED IN EMOTIONAL PROCESSING, PARTICULARLY THE AMYGDALA, ANTERIOR CINGULATE, ANTERIOR INSULA, AND PREFRONTAL CORTEX. RESTING-STATE FUNCTIONAL MRI (FMRI) SHOWED SIGNIFICANTLY REDUCED FUNCTIONAL CONNECTIVITY INVOLVING THE ANTERIOR INSULA AND LATERAL PORTIONS OF THE PREFRONTAL CORTEX. CORRELATION ANALYSIS REVEALED THAT CHANGES IN CONNECTIVITY BETWEEN THE VENTROLATERAL PREFRONTAL CORTEX AND THE RIGHT ANTERIOR INSULA WERE ASSOCIATED WITH CHANGES IN ANXIETY. ALTHOUGH IT SHOULD BE NOTED THAT THESE ANALYSES WERE PRELIMINARY AND EXPLORATORY, IT PROVIDES THE FIRST EVIDENCE THAT 4 WEEKS OF B. PRANAYAMA SIGNIFICANTLY REDUCE THE LEVELS OF ANXIETY AND NEGATIVE AFFECT, AND THAT THESE CHANGES ARE ASSOCIATED WITH THE MODULATION OF ACTIVITY AND CONNECTIVITY IN BRAIN AREAS INVOLVED IN EMOTION PROCESSING, ATTENTION, AND AWARENESS. THE STUDY WAS REGISTERED AT HTTPS://WWW.ENSAIOSCLINICOS.GOV.BR/RG/RBR-2GV5C2/(RBR-2GV5C2).	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
18 1972  28 SHORT-TERM SAHAJA YOGA MEDITATION TRAINING MODULATES BRAIN STRUCTURE AND SPONTANEOUS ACTIVITY IN THE EXECUTIVE CONTROL NETWORK. INTRODUCTION: WHILE CROSS-SECTIONAL STUDIES HAVE SHOWN NEURAL CHANGES IN LONG-TERM MEDITATORS, THEY MIGHT BE CONFOUNDED BY SELF-SELECTION AND POTENTIAL BASELINE DIFFERENCES BETWEEN MEDITATORS AND NON MEDITATORS. PROSPECTIVE LONGITUDINAL STUDIES OF THE EFFECTS OF MEDITATION IN NAIVE SUBJECTS ARE MORE CONCLUSIVE WITH RESPECT TO CAUSAL INFERENCES, BUT RELATED EVIDENCE IS SO FAR LIMITED. METHODS: HERE, WE ASSESSED THE EFFECTS OF A 4-WEEK SAHAJA YOGA MEDITATION TRAINING ON GRAY MATTER DENSITY AND SPONTANEOUS RESTING-STATE BRAIN ACTIVITY IN A GROUP OF 12 MEDITATION-NAIVE HEALTHY ADULTS. RESULTS: COMPARED WITH 30 CONTROL SUBJECTS, THE PARTICIPANTS TO MEDITATION TRAINING SHOWED INCREASED GRAY MATTER DENSITY AND CHANGES IN THE COHERENCE OF INTRINSIC BRAIN ACTIVITY IN TWO ADJACENT REGIONS OF THE RIGHT INFERIOR FRONTAL GYRUS ENCOMPASSING THE ANTERIOR COMPONENT OF THE EXECUTIVE CONTROL NETWORK. BOTH THESE MEASURES CORRELATED WITH SELF-REPORTED WELL-BEING SCORES IN THE MEDITATION GROUP. CONCLUSIONS: THE SIGNIFICANT IMPACT OF A BRIEF MEDITATION TRAINING ON BRAIN REGIONS ASSOCIATED WITH ATTENTION, SELF-CONTROL, AND SELF-AWARENESS MAY REFLECT THE ENGAGEMENT OF COGNITIVE CONTROL SKILLS IN SEARCHING FOR A STATE OF MENTAL SILENCE, A DISTINCTIVE FEATURE OF SAHAJA YOGA MEDITATION. THE MANIFOLD IMPLICATIONS OF THESE FINDINGS INVOLVE BOTH MANAGERIAL AND REHABILITATIVE SETTINGS CONCERNED WITH WELL-BEING AND EMOTIONAL STATE IN NORMAL AND PATHOLOGICAL CONDITIONS.	2019	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
19 2531  23 YOGA EFFECTS ON BRAIN HEALTH: A SYSTEMATIC REVIEW OF THE CURRENT LITERATURE. YOGA IS THE MOST POPULAR COMPLEMENTARY HEALTH APPROACH PRACTICED BY ADULTS IN THE UNITED STATES. IT IS AN ANCIENT MIND AND BODY PRACTICE WITH ORIGINS IN INDIAN PHILOSOPHY. YOGA COMBINES PHYSICAL POSTURES, RHYTHMIC BREATHING AND MEDITATIVE EXERCISE TO OFFER THE PRACTITIONERS A UNIQUE HOLISTIC MIND-BODY EXPERIENCE. WHILE THE HEALTH BENEFITS OF PHYSICAL EXERCISE ARE WELL ESTABLISHED, IN RECENT YEARS, THE ACTIVE ATTENTIONAL COMPONENT OF BREATHING AND MEDITATION PRACTICE HAS GARNERED INTEREST AMONG EXERCISE NEUROSCIENTISTS. AS THE SCIENTIFIC EVIDENCE FOR THE PHYSICAL AND MENTAL HEALTH BENEFITS OF YOGA CONTINUES TO GROW, THIS ARTICLE AIMS TO SUMMARIZE THE CURRENT KNOWLEDGE OF YOGA PRACTICE AND ITS DOCUMENTED POSITIVE EFFECTS FOR BRAIN STRUCTURE AND FUNCTION, AS ASSESSED WITH MRI, FMRI, AND SPECT. WE REVIEWED 11 STUDIES EXAMINING THE EFFECTS OF YOGA PRACTICE ON THE BRAIN STRUCTURES, FUNCTION AND CEREBRAL BLOOD FLOW. COLLECTIVELY, THE STUDIES DEMONSTRATE A POSITIVE EFFECT OF YOGA PRACTICE ON THE STRUCTURE AND/OR FUNCTION OF THE HIPPOCAMPUS, AMYGDALA, PREFRONTAL CORTEX, CINGULATE CORTEX AND BRAIN NETWORKS INCLUDING THE DEFAULT MODE NETWORK (DMN). THE STUDIES OFFER PROMISING EARLY EVIDENCE THAT BEHAVIORAL INTERVENTIONS LIKE YOGA MAY HOLD PROMISE TO MITIGATE AGE-RELATED AND NEURODEGENERATIVE DECLINES AS MANY OF THE REGIONS IDENTIFIED ARE KNOWN TO DEMONSTRATE SIGNIFICANT AGE-RELATED ATROPHY.	2019	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
20 2915  22 [SYSTEMATIC REVIEW OF YOGA FOR DEPRESSION AND QUALITY OF SLEEP IN THE ELDERLY]. BACKGROUND: AGING AND AGE-RELATED HEALTH PROBLEMS ARE MAJOR ISSUES OF CONCERN FOR COMMUNITY HEALTH SERVICES. YOGA IS AN EXERCISE WITH BOTH PHYSIOLOGICAL AND PSYCHOLOGICAL EFFECTS ON AGING. ALTHOUGH MANY STUDIES HAVE ASSESSED THE EFFECTIVENESS OF YOGA IN THE ELDERLY, LITTLE INFORMATION IS AVAILABLE IN THE LITERATURE TO SUPPORT EMPIRICAL CONCLUSIONS. PURPOSE: THIS REVIEW SYNTHESIZES AND CHARACTERIZES FINDINGS RELATED TO THE EFFECTS OF YOGA ON DEPRESSION AND QUALITY OF SLEEP IN THE ELDERLY. METHODS: RESEARCHERS USED KEYWORDS INCLUDING YOGA, ELDERLY, AGED / OLDER ADULT, DEPRESSION, SLEEP, AND QUALITY TO SEARCH 6 ELECTRONIC DATABASES FOR RELEVANT STUDIES PUBLISHED PRIOR TO MARCH 2013. INCLUSION AND EXCLUSION CRITERIA WERE USED TO SCREEN IDENTIFIED STUDY ABSTRACTS. THE JADAD SCALE APPRAISED THE QUALITY OF IDENTIFIED STUDIES. RESULTS: SEVEN STUDIES MET THE INCLUSION CRITERIA. FIVE STUDIES FOUND SIGNIFICANT CHANGES IN PARTICIPANT DEPRESSION SYMPTOMS AFTER DOING YOGA. THREE STUDIES FOUND SIGNIFICANT EFFECTS ON THE QUALITY OF SLEEP OF PARTICIPANTS AFTER 6 MONTHS OF DOING YOGA. CONCLUSION: YOGA SIGNIFICANTLY REDUCED THE DEPRESSIVE SYMPTOMS OF ELDERLY PARTICIPANTS AND IMPROVED THEIR QUALITY OF SLEEP AFTER 6 MONTHS. FINDINGS WERE SIMILAR FOR ELDERLY LIVING IN INSTITUTIONS AND IN THE COMMUNITY. HOWEVER, THE MAJORITY OF PARTICIPANTS IN THE ASSESSED STUDIES WERE WOMEN CHARACTERIZED BY A HIGH LEVEL OF SOCIAL PARTICIPATION AND PROACTIVE PARTICIPATION IN HEALTH PROMOTION ACTIVITIES. FUTURE STUDIES SHOULD BROADEN THE SCOPE OF RESEARCH TO ADDRESS DIFFERENT AGING POPULATIONS AND USE LONG-TERM COHORT OBSERVATIONS IN ORDER TO BETTER ELICIT THE EFFECTIVENESS OF YOGA AND TO DEVELOP STRATEGIES TO INTRODUCE YOGA INTO DAILY ACTIVITIES.	2014