1 2163 142 THE EFFECTS OF YOGA AND QUIET REST ON SUBJECTIVE LEVELS OF ANXIETY AND PHYSIOLOGICAL CORRELATES: A 2-WAY CROSSOVER RANDOMIZED TRIAL. BACKGROUND: REST OR ACUTE EXERCISE CAN DECREASE STATE ANXIETY, WITH SOME EVIDENCE SHOWING EXERCISE TO PREVENT LABORATORY-INDUCED ELEVATIONS IN ANXIETY. NO STUDY HAS EXAMINED WHETHER YOGA PROVIDES SHORT-TERM PROTECTION AGAINST LABORATORY-INDUCED ANXIETY. THE AIM OF THIS STUDY WAS TO EXAMINE THE EFFECTIVENESS OF AN ACUTE YOGAFIT SESSION ON STATE ANXIETY AND MEASURES OF HEART RATE VARIABILITY (HRV) TO DETERMINE WHETHER YOGA PROVIDES SHORT-TERM PROTECTION AGAINST EMOTIONAL PICTURE STIMULI. METHODS: A RANDOMIZED REPEATED-MEASURES CROSSOVER CLINICAL TRIAL WAS PERFORMED. FORTY HEALTHY, FEMALE COLLEGE STUDENTS COMPLETED A 30 MIN SESSION OF YOGAFIT AND A TIME-MATCHED SEATED REST CONDITION ON SEPARATE DAYS. AFTER EACH CONDITION, PARTICIPANTS VIEWED 30 MIN OF EMOTIONAL PICTURE STIMULI. STATE ANXIETY, HEART RATE AND TIME-DOMAIN AND FREQUENCY-DOMAIN MEASURES OF HRV WERE ASSESSED BASELINE, POST- CONDITION, AND POST-EXPOSURE TO EMOTIONAL STIMULI. DATA WERE ANALYSED USING A CONDITION X TIME (2 X 3) REPEATED-MEASURES ANOVA. RESULTS: POST-HOC COMPARISONS INDICATE THE FOLLOWING: (1) STATE ANXIETY SIGNIFICANTLY DECREASED FROM BASELINE TO POST-CONDITION FOR BOTH YOGA AND REST (P = 0.001) BUT RETURNED TO BASELINE VALUES FOLLOWING EXPOSURE TO EMOTIONAL STIMULI (P < 0.001) FOR BOTH CONDITIONS; (2) HEART RATE DECREASED POST-CONDITION TO POST-EXPOSURE (P = 0.020) AND BASELINE TO POST-EXPOSURE (P = 0.033) FOR BOTH CONDITIONS; (3) TIME-DOMAIN MEASURE OF HRV SHOWED A SIGNIFICANT INCREASE IN HRV BETWEEN BASELINE AND POST-CONDITION (P = 0 .019), POST-CONDITION AND POST-EXPOSURE (P = 0 .007), AND BETWEEN BASELINE AND POST-EXPOSURE (P < 0.001). CONCLUSIONS: BOTH YOGAFIT AND SEATED REST WERE EFFECTIVE AT ACUTELY REDUCING STATE ANXIETY POST-CONDITION, BUT NOT AT PREVENTING AN INDUCED ANXIETY RESPONSE POST-EXPOSURE. FOLLOWING EXPOSURE TO THE EMOTIONALLY STIMULATING PICTURES, THERE WAS A SHIFT FROM THE HIGH FREQUENCY-DOMAIN TO THE LOW FREQUENCY-DOMAIN AND AN INCREASE IN THE TIME-DOMAIN MEASURE OF HRV FOR BOTH THE YOGAFIT AND THE QUIET REST CONDITION. TRIAL REGISTRATION: RETROSPECTIVELY REGISTERED 2/16/2018, CLINICALTRIALS.GOV, IDENTIFIER: NCT03458702 .	2018	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
2  267  48 ACUTE FETAL BEHAVIORAL RESPONSE TO PRENATAL YOGA: A SINGLE, BLINDED, RANDOMIZED CONTROLLED TRIAL (TRY YOGA). BACKGROUND: IN 2012, YOGA WAS PRACTICED BY 20 MILLION AMERICANS, OF WHOM 82% WERE WOMEN. A RECENT LITERATURE REVIEW ON PRENATAL YOGA NOTED A REDUCTION IN SOME PREGNANCY COMPLICATIONS (IE, PRETERM BIRTH, LUMBAR PAIN, AND GROWTH RESTRICTION) IN THOSE WHO PRACTICED YOGA; TO DATE, THERE IS NO EVIDENCE ON FETAL RESPONSE AFTER YOGA. OBJECTIVES: WE AIMED TO CHARACTERIZE THE ACUTE CHANGES IN MATERNAL AND FETAL RESPONSE TO PRENATAL YOGA EXERCISES USING COMMON STANDARDIZED TESTS TO ASSESS THE WELL-BEING OF THE MATERNAL-FETAL UNIT. STUDY DESIGN: WE CONDUCTED A SINGLE, BLINDED, RANDOMIZED CONTROLLED TRIAL. UNCOMPLICATED PREGNANCIES BETWEEN 28 0/7 AND 36 6/7 WEEKS WITH A NONANOMALOUS SINGLETON FETUS OF WOMEN WHO DID NOT SMOKE, USE NARCOTICS, OR HAVE PRIOR EXPERIENCE WITH YOGA WERE INCLUDED. A COMPUTER-GENERATED SIMPLE RANDOMIZATION SEQUENCE WITH A 1:1 ALLOCATION RATIO WAS USED TO RANDOMIZE PARTICIPANTS INTO THE YOGA OR CONTROL GROUP. WOMEN IN THE YOGA GROUP PARTICIPATED IN A 1-TIME, 1 HOUR YOGA CLASS WITH A CERTIFIED INSTRUCTOR WHO TAUGHT A PREDETERMINED YOGA SEQUENCE. IN THE CONTROL GROUP, EACH PARTICIPANT ATTENDED A 1-TIME, 1 HOUR POWERPOINT PRESENTATION BY AN OBSTETRICIAN ON AMERICAN CONGRESS OF OBSTETRICIANS AND GYNECOLOGISTS RECOMMENDATIONS FOR EXERCISE, NUTRITION, AND OBESITY IN PREGNANCY. ALL PARTICIPANTS UNDERWENT PRE- AND POSTINTERVENTION TESTING, WHICH CONSISTED OF UMBILICAL AND UTERINE ARTERY DOPPLER ULTRASOUND, NONSTRESS TESTING, A BIOPHYSICAL PROFILE, MATERNAL BLOOD PRESSURE, AND MATERNAL HEART RATE. A BOARD-CERTIFIED MATERNAL-FETAL MEDICINE SPECIALIST, AT A DIFFERENT TERTIARY CENTER, INTERPRETED ALL NONSTRESS TESTS AND BIOPHYSICAL PROFILE DATA AND WAS BLINDED TO GROUP ASSIGNMENT AND PRE- OR POSTINTERVENTION TESTING. THE PRIMARY OUTCOME WAS A CHANGE IN UMBILICAL ARTERY DOPPLER SYSTOLIC TO DIASTOLIC RATIO. SAMPLE SIZE CALCULATIONS INDICATED 19 WOMEN PER GROUP WOULD BE SUFFICIENT TO DETECT THIS DIFFERENCE IN DOPPLER INDICES (ALPHA, 0.05; POWER, 80%). DATA WERE ANALYZED USING A REPEATED-MEASURES ANALYSIS OF VARIANCE, A CHI(2), AND A FISHER EXACT TEST. A VALUE OF P < .05 WAS CONSIDERED SIGNIFICANT. RESULTS: OF THE 52 WOMEN RANDOMIZED, 46 (88%) COMPLETED THE STUDY. THERE WAS NO CLINICALLY SIGNIFICANT CHANGE IN UMBILICAL ARTERY SYSTOLIC TO DIASTOLIC RATIO (P = .34), PULSATILITY INDEX (P = .53), OR RESISTANCE INDEX (P = .66) BETWEEN THE 2 GROUPS BEFORE AND AFTER THE INTERVENTION. FETAL AND MATERNAL HEART RATE, MATERNAL BLOOD PRESSURE, AND UTERINE ARTERY DOPPLERS REMAINED UNCHANGED OVER TIME. WHEN UMBILICAL ARTERY INDICES WERE INDIVIDUALLY COMPARED WITH GESTATIONAL AGE REFERENCES, THERE WAS NO DIFFERENCE BETWEEN THOSE WHO IMPROVED OR WORSENED BETWEEN THE GROUPS. CONCLUSION: THERE WAS NO SIGNIFICANT CHANGE IN FETAL BLOOD FLOW ACUTELY AFTER PERFORMING YOGA FOR THE FIRST TIME IN PREGNANCY. YOGA CAN BE RECOMMENDED FOR LOW-RISK WOMEN TO BEGIN DURING PREGNANCY.	2016	

3 2046  40 THE ACUTE IMPACT OF HATHA YOGA ON CRAVING AMONG SMOKERS ATTEMPTING TO REDUCE OR QUIT. INTRODUCTION: DESPITE NEGATIVE EFFECTS OF SMOKING, SMOKERS HAVE DIFFICULTY QUITTING, SUGGESTING A NEED FOR ADDITIONAL STRATEGIES TO HELP THEM QUIT. A SINGLE-SESSION HATHA YOGA INTERVENTION ACUTELY REDUCED CRAVING AMONG NICOTINE-DEPRIVED SMOKERS NOT ATTEMPTING TO REDUCE OR QUIT, YET IT IS UNKNOWN IF IT REDUCES CRAVING AMONG THOSE ATTEMPTING TO CHANGE THEIR SMOKING. THUS, THIS STUDY TESTED THE EFFICACY OF A SINGLE-SESSION HATHA YOGA INTERVENTION FOR ACUTELY REDUCING CRAVING AMONG SMOKERS ATTEMPTING TO REDUCE OR QUIT SMOKING. METHODS: DATA PRESENTED ARE PART OF A LARGER DISSERTATION PROJECT. PARTICIPANTS WERE 55 COMMUNITY-RECRUITED SMOKERS (62% MALE) MOTIVATED TO REDUCE OR QUIT SMOKING RANDOMIZED TO ONE SESSION OF HATHA YOGA (N = 25) OR WELLNESS CONTROL (IE, READING EDUCATIONAL MATERIALS ABOUT HEALTHY LIFESTYLE; N = 30) ON THEIR INTERVENTION DAY (IE, THE DAY ON WHICH THEY BEGAN TO REDUCE OR QUIT SMOKING). PARTICIPANTS RATED, "I HAVE A DESIRE FOR A CIGARETTE RIGHT NOW," ON A 7-POINT LIKERT SCALE IMMEDIATELY BEFORE AND AFTER THE INTERVENTION. RESULTS: AFTER STATISTICALLY CONTROLLING FOR CO IN BREATH, PARTICIPANT TYPE, AGE, GENDER, RACE, AND ETHNICITY, A SIGNIFICANT TIME X CONDITION INTERACTION WAS FOUND, F(1, 47) = 4.72, P = .035, ETAP2 = .09, SUGGESTING CRAVING DECREASED AT A GREATER RATE IN THE HATHA YOGA CONDITION RELATIVE TO THE WELLNESS CONDITION. CONCLUSIONS: RESULTS FROM THIS STUDY ADD TO A GROWING BODY OF RESEARCH DEMONSTRATING THE POTENTIAL CLINICAL UTILITY OF HATHA YOGA AS AN ADJUNCTIVE INTERVENTION TOOL FOR SMOKING CESSATION. IMPLICATIONS: THIS IS THE FIRST KNOWN STUDY TO TEST THE IMPACT OF A SINGLE-SESSION HATHA YOGA INTERVENTION ON CRAVING AMONG ADULT SMOKERS ATTEMPTING TO REDUCE OR QUIT SMOKING. WE FOUND THAT 30 MINUTES OF HATHA YOGA PRODUCED A GREATER REDUCTION IN CRAVING COMPARED TO A 30-MINUTE WELLNESS CONTROL CONDITION. THIS RELATIONSHIP WAS EVIDENT EVEN AFTER STATISTICALLY ACCOUNTING FOR OTHER IMPORTANT VARIABLES (EG, GENDER). RESULTS OF THIS STUDY ADD TO A GROWING BODY OF LITERATURE DEMONSTRATING THE POTENTIAL CLINICAL UTILITY OF HATHA YOGA AS AN ADJUNCTIVE INTERVENTION STRATEGY FOR SMOKING CESSATION.	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
4 1258  34 FIFTEEN MINUTES OF CHAIR-BASED YOGA POSTURES OR GUIDED MEDITATION PERFORMED IN THE OFFICE CAN ELICIT A RELAXATION RESPONSE. THIS STUDY COMPARED ACUTE (15 MIN) YOGA POSTURE AND GUIDED MEDITATION PRACTICE, PERFORMED SEATED IN A TYPICAL OFFICE WORKSPACE, ON PHYSIOLOGICAL AND PSYCHOLOGICAL MARKERS OF STRESS. TWENTY PARTICIPANTS (39.6 +/- 9.5 YR) COMPLETED THREE CONDITIONS: YOGA, MEDITATION, AND CONTROL (I.E., USUAL WORK) SEPARATED BY >/=24 HRS. YOGA AND MEDITATION SIGNIFICANTLY REDUCED PERCEIVED STRESS VERSUS CONTROL, AND THIS EFFECT WAS MAINTAINED POSTINTERVENTION. YOGA INCREASED HEART RATE WHILE MEDITATION REDUCED HEART RATE VERSUS CONTROL (P < 0.05). RESPIRATION RATE WAS REDUCED DURING YOGA AND MEDITATION VERSUS CONTROL (P < 0.05). DOMAINS OF HEART RATE VARIABILITY (E.G., SDNN AND TOTAL POWER) WERE SIGNIFICANTLY REDUCED DURING CONTROL VERSUS YOGA AND MEDITATION. SYSTOLIC AND DIASTOLIC BLOOD PRESSURE WERE REDUCED SECONDARY TO MEDITATION VERSUS CONTROL ONLY (P < 0.05). PHYSIOLOGICAL ADAPTATIONS GENERALLY REGRESSED TOWARD BASELINE POSTINTERVENTION. IN CONCLUSION, YOGA POSTURES OR MEDITATION PERFORMED IN THE OFFICE CAN ACUTELY IMPROVE SEVERAL PHYSIOLOGICAL AND PSYCHOLOGICAL MARKERS OF STRESS. THESE EFFECTS MAY BE AT LEAST PARTIALLY MEDIATED BY REDUCED RESPIRATION RATE.	2012	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
5 1215  46 EXPLORING THE EFFECTS OF YOGA THERAPY ON HEART RATE VARIABILITY AND PATIENT-REPORTED OUTCOMES AFTER CANCER TREATMENT: A STUDY PROTOCOL. BACKGROUND: FOLLOWING CANCER TREATMENT, ADULTS COMMONLY REPORT WORSENED PATIENT-REPORTED OUTCOMES (PROS) SUCH AS ANXIETY, STRESS, DEPRESSION, PERSISTENT AND UPSETTING COGNITIVE COMPLAINTS, UNRELENTING FATIGUE, AND REDUCED QUALITY OF LIFE. POORER PROS ARE ASSOCIATED WITH DISRUPTED AUTONOMIC NERVOUS SYSTEM FUNCTIONING AS MEASURED BY HEART RATE VARIABILITY (HRV), BOTH OF WHICH HAVE BEEN ASSOCIATED WITH GREATER MORBIDITY AND MORTALITY. INTERVENTIONS TO IMPROVE HRV AND PROS AMONG ADULTS FOLLOWING CANCER TREATMENT ARE NEEDED. YOGA THERAPY HOLDS PROMISE AS AN INTERVENTION TO IMPROVE HRV AND PROS. THEREFORE, WE CONDUCTED A SINGLE-SUBJECT EXPLORATORY EXPERIMENTAL STUDY TO INVESTIGATE THE EFFECTS OF YOGA THERAPY ON HRV AND SPECIFIC PROS (IE, CANCER-RELATED FATIGUE, ANXIETY, COGNITIVE FUNCTION, DEPRESSION, STRESS, QUALITY OF LIFE) IN ADULTS TREATED FOR CANCER. TO REDUCE PUBLICATION BIAS, IMPROVE REPRODUCIBILITY, AND SERVE AS A REFERENCE FOR FORTHCOMING REPORTING OF STUDY RESULTS, WE PRESENT THE STUDY PROTOCOL FOR THIS STUDY HEREIN. METHODS: PARTICIPANTS WERE ADULTS WHO COMPLETED CANCER TREATMENT THAT WERE RECRUITED FROM THE OTTAWA INTEGRATIVE CANCER CENTRE. CONSENTING AND ELIGIBLE PARTICIPANTS RECEIVED ONE 1:1 YOGA THERAPY SESSION (IE, 1 PARTICIPANT, 1 YOGA THERAPIST) AND 6 WEEKLY GROUP-BASED YOGA THERAPY SESSIONS (IE, 2-3 PARTICIPANTS, 1 YOGA THERAPIST). PARTICIPANTS COMPLETED ASSESSMENTS 7 TIMES: 3 TIMES PRIOR TO THE PROGRAM (IE, -6 WEEKS, -3 WEEKS, IMMEDIATELY PRIOR TO THE 1:1 YOGA THERAPY SESSION), IMMEDIATELY FOLLOWING THE 1:1 YOGA THERAPY SESSION, PRIOR TO THE FIRST GROUP-BASED YOGA THERAPY SESSION, AFTER THE LAST GROUP-BASED YOGA THERAPY SESSION, AND AT A 6-WEEK FOLLOW-UP. HIERARCHICAL LINEAR MODELING WILL BE USED TO TEST THE AVERAGE EFFECTS OF THE YOGA THERAPY PROGRAM ACROSS PARTICIPANTS. DISCUSSION: THIS STUDY WILL EXPLORE SEVERAL NOVEL HYPOTHESES, INCLUDING WHETHER YOGA THERAPY CAN IMPROVE HRV AND/OR SPECIFIC PROS AMONG ADULTS TREATED FOR CANCER ACUTELY (IE, DURING A 1:1 YOGA THERAPY SESSION) AND/OR THROUGH REPEATED EXPOSURE (IE, AFTER COMPLETING 6 WEEKS OF GROUP-BASED YOGA THERAPY). ALTHOUGH THE FINDINGS WILL REQUIRE CONFIRMATION OR REFUTATION IN FUTURE TRIALS, THEY MAY PROVIDE INITIAL EVIDENCE THAT YT MAY BENEFIT ADULTS TREATED FOR CANCER. TRIAL REGISTRATION: ISRCTN REGISTRY, ISRCTN64763228. REGISTERED ON DECEMBER 12, 2021. THIS TRIAL WAS REGISTERED RETROSPECTIVELY. URL OF TRIAL REGISTRY RECORD: HTTPS://WWW.ISRCTN.COM/ISRCTN64763228.	2022	
                                                                                                                                                                                                                                                                                                                                                                                                          
6 2474  51 YOGA AS AN ADJUNCT ACTIVITY FOR MEDICAL STUDENTS LEARNING ANATOMY. BACKGROUND: MEDICAL STUDENTS EXPERIENCE HIGH LEVELS OF STRESS DURING TRAINING DUE TO DEMANDING COURSE LOADS WHICH OFTEN LEAVES LESS TIME FOR SELF-CARE. THIS STUDY COMBINES THE SELF-CARE TECHNIQUE OF YOGA WITH LEARNING ANATOMICAL LOCATIONS, INNERVATIONS, ACTIONS, AND FUNCTIONS OF THE MUSCLES AND ORGANS TO DETERMINE IF ANATOMY TESTS SCORES ARE IMPROVED AND WHETHER STUDENTS' STRESS LEVELS ATTENUATE FROM PARTICIPATING IN YOGA. METHODS: IN THIS RANDOMIZED CONTROLLED STUDY, 64 STUDENT VOLUNTEERS WERE RANDOMIZED INTO EITHER A YOGA INTERVENTION GROUP OR WAIT LIST CONTROL GROUP THROUGHOUT THE M1 ANATOMY COURSE. THE YOGA GROUP (N = 32) PARTICIPATED IN 8 YOGA SESSIONS SYNCED WITH THE ANATOMY TOPICS THEY WERE LEARNING IN LECTURE. THE WAIT LIST GROUP (N = 32) WENT THROUGH THEIR NORMAL ANATOMY CURRICULUM BUT HAD AN OPTION TO PARTICIPATE IN THE SAME YOGA SESSIONS AFTER THE ANATOMY COURSE. THE PRIMARY RESEARCH PURPOSE WAS TO DETERMINE WHETHER YOGA IMPROVED ANATOMY EXAM PERFORMANCE BY COMPARING FOUR ANATOMY EXAM SCORES BETWEEN THE TWO GROUPS. THE SECONDARY RESEARCH PURPOSES INCLUDED THE FOLLOWING: TO DETERMINE WHETHER YOGA CLASSES INCLUDING ANATOMY TEACHING STILL CONFERRED ACUTE AND LONG-LASTING STRESS RELIEF BY, RESPECTIVELY, COMPARING A STUDENTS' OWN PRE- AND POST-YOGA STRESS LEVEL AND SELF-PERCEIVED STRESS LEVELS BETWEEN THE TWO GROUPS; AND TO DETERMINE IF A STUDENT'S CONFIDENCE IN ANATOMY WAS IMPROVED AFTER A YOGA SESSION. RESULTS: THERE WAS NO SIGNIFICANT DIFFERENCE IN ANATOMY EXAM PERFORMANCE BETWEEN STUDENTS WHO RECEIVED YOGA AND THOSE ON THE WAITLIST (ALL P > 0.05). FOR STUDENTS WHO RECEIVED YOGA, THEIR AVERAGE SELF-REPORTED STRESS LEVELS DECREASED AFTER EACH YOGA SESSION, THEIR AVERAGE DASS (DEPRESSION, ANXIETY AND STRESS SCALE) SCORE DECREASED AFTER A YOGA SESSION, BUT THEY WERE NOT SIGNIFICANTLY LESS STRESSED THAN THEIR WAITLIST PEERS PRIOR TO AN EXAM, AND THEIR SELF-REPORTED CONFIDENCE IN ANATOMY MATERIAL RELATED TO THE BACK, UPPER EXTREMITY, HEAD AND NECK, AND ABDOMEN/PELVIS INCREASED. CONCLUSION: WITH THIS SAMPLE, THERE WAS NO EVIDENCE THAT YOGA SESSIONS PAIRED WITH ANATOMY LECTURE MATERIAL IMPROVED OVERALL ANATOMY EXAM PERFORMANCE, AS OPPOSED TO ONLY THE MUSCULOSKELETAL PORTION WHICH OTHER STUDIES HAVE LOOKED AT. HOWEVER, YOGA ACUTELY REDUCED STRESS LEVELS, AND SUBJECTIVE FEELINGS OF KNOWLEDGE IMPROVEMENT WERE NOTED BY PARTICIPANTS. BOTH OF THESE CAN PROVIDE BENEFITS TO MEDICAL STUDENTS.	2022	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
7 1317  42 HEART RATE VARIABILITY CHANGES DURING HIGH FREQUENCY YOGA BREATHING AND BREATH AWARENESS. BACKGROUND: PRE AND POST COMPARISON AFTER ONE MINUTE OF HIGH FREQUENCY YOGA BREATHING (HFYB) SUGGESTED THAT THE HFYB MODIFIES THE AUTONOMIC STATUS BY INCREASING SYMPATHETIC MODULATION, BUT ITS EFFECT DURING THE PRACTICE WAS NOT ASSESSED. METHODS: THIRTY-EIGHT MALE VOLUNTEERS WITH GROUP AVERAGE AGE +/- S.D., 23.3 +/- 4.4 YEARS WERE EACH ASSESSED ON TWO SEPARATE DAYS IN TWO SESSIONS, (I) HFYB AND (II) BREATH AWARENESS. EACH SESSION WAS FOR 35 MINUTES, WITH 3 PERIODS, I.E., PRE (5 MINUTES), DURING HFYB OR BREATH AWARENESS (15 MINUTES) AND POST (5 MINUTES). RESULTS: THERE WAS A SIGNIFICANT DECREASE IN NN50, PNN50 AND THE MEAN RR INTERVAL DURING AND AFTER HFYB AND AFTER BREATH AWARENESS, COMPARED TO THE RESPECTIVE 'PRE' VALUES (P < 0.05) (REPEATED MEASURES ANOVA FOLLOWED BY POST-HOC ANALYSIS). THE LF POWER INCREASED AND HF POWER DECREASED DURING AND AFTER BREATH AWARENESS AND LF/HF RATIO INCREASED AFTER BREATH AWARENESS (P < 0.05). CONCLUSION: THE RESULTS SUGGEST THAT THERE WAS REDUCED PARASYMPATHETIC MODULATION DURING AND AFTER HFYB AND INCREASED SYMPATHETIC MODULATION WITH REDUCED PARASYMPATHETIC MODULATION DURING AND AFTER BREATH AWARENESS.	2011	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
8 2364  36 VOLUNTARY HEART RATE REDUCTION FOLLOWING YOGA USING DIFFERENT STRATEGIES. BACKGROUND/AIMS: ONE MONTH OF YOGA TRAINING HAS BEEN SHOWN TO REDUCE THE PULSE RATE VOLUNTARILY WITHOUT USING EXTERNAL CUES. HENCE, THE PRESENT STUDY WAS DESIGNED TO UNDERSTAND THE STRATEGIES USED BY YOGA PRACTITIONERS AND AUTONOMIC CHANGES ASSOCIATED WITH VOLUNTARY HEART RATE REDUCTION. MATERIALS AND METHODS: FIFTY VOLUNTEERS (GROUP MEAN AGE +/- S.D., 25.4 +/- 4.8 YEARS; 25 MALES) WERE ASSESSED IN TWO TRIALS ON SEPARATE DAYS. EACH TRIAL WAS FOR 12 MINUTES, WITH A 'PRE' STATE AND 'DURING' STATE OF 6 MINUTES EACH. FOR BOTH TRIALS THE 'PRE' STATE WAS RELAXATION WITH EYES CLOSED. IN THE 'DURING' STATE OF TRIAL I, SUBJECTS WERE ASKED TO VOLUNTARILY REDUCE THEIR HEART RATE USING A STRATEGY OF THEIR CHOICE. FROM THEIR RESPONSES TO SPECIFIC QUESTIONS IT WAS DETERMINED THAT 22 OUT OF 50 PERSONS USED BREATH REGULATION AS A STRATEGY. HENCE, IN THE 'DURING' STATE OF TRIAL II, SUBJECTS WERE ASKED TO VOLUNTARILY REDUCE THEIR HEART RATE BY BREATH REGULATION. RESULTS: IN THE FIRST TRIAL, THE HEART RATE WAS REDUCED BY AN AVERAGE OF 19.6 BEATS PER MINUTE AND IN THE SECOND TRIAL (WITH BREATH REGULATION EXCLUSIVELY) AN AVERAGE DECREASE OF 22.2 BEATS PER MINUTE WAS ACHIEVED. CONCLUSIONS: HENCE, THE STRATEGY USED DID NOT MARKEDLY ALTER THE OUTCOME.	2013	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
9  668  53 EFFECT OF A 16-WEEK BIKRAM YOGA PROGRAM ON HEART RATE VARIABILITY AND ASSOCIATED CARDIOVASCULAR DISEASE RISK FACTORS IN STRESSED AND SEDENTARY ADULTS: A RANDOMIZED CONTROLLED TRIAL. BACKGROUND: CHRONIC ACTIVATION OF THE STRESS-RESPONSE CAN CONTRIBUTE TO CARDIOVASCULAR DISEASE RISK, PARTICULARLY IN SEDENTARY INDIVIDUALS. THIS STUDY INVESTIGATED THE EFFECT OF A BIKRAM YOGA INTERVENTION ON THE HIGH FREQUENCY POWER COMPONENT OF HEART RATE VARIABILITY (HRV) AND ASSOCIATED CARDIOVASCULAR DISEASE (CVD) RISK FACTORS (I.E. ADDITIONAL DOMAINS OF HRV, HEMODYNAMIC, HEMATOLOGIC, ANTHROPOMETRIC AND BODY COMPOSITION OUTCOME MEASURES) IN STRESSED AND SEDENTARY ADULTS. METHODS: ELIGIBLE ADULTS WERE RANDOMIZED TO AN EXPERIMENTAL GROUP (N = 29) OR A NO TREATMENT CONTROL GROUP (N = 34). EXPERIMENTAL GROUP PARTICIPANTS WERE INSTRUCTED TO ATTEND THREE TO FIVE SUPERVISED BIKRAM YOGA CLASSES PER WEEK FOR 16 WEEKS AT LOCAL STUDIOS. OUTCOME MEASURES WERE ASSESSED AT BASELINE (WEEK 0) AND COMPLETION (WEEK 17). RESULTS: SIXTY-THREE ADULTS (37.2 +/- 10.8 YEARS, 79% WOMEN) WERE INCLUDED IN THE INTENTION-TO-TREAT ANALYSIS. THE EXPERIMENTAL GROUP ATTENDED 27 +/- 18 CLASSES. ANALYSES OF COVARIANCE REVEALED NO SIGNIFICANT CHANGE IN THE HIGH-FREQUENCY COMPONENT OF HRV (P = 0.912, PARTIAL ETA (2) = 0.000) OR IN ANY SECONDARY OUTCOME MEASURE BETWEEN GROUPS OVER TIME. HOWEVER, REGRESSION ANALYSES REVEALED THAT HIGHER ATTENDANCE IN THE EXPERIMENTAL GROUP WAS ASSOCIATED WITH SIGNIFICANT REDUCTIONS IN DIASTOLIC BLOOD PRESSURE (P = 0.039; PARTIAL ETA (2) = 0.154), BODY FAT PERCENTAGE (P = 0.001, PARTIAL ETA (2) = 0.379), FAT MASS (P = 0.003, PARTIAL ETA (2) = 0.294) AND BODY MASS INDEX (P = 0.05, PARTIAL ETA (2) = 0.139). CONCLUSIONS: A 16-WEEK BIKRAM YOGA PROGRAM DID NOT INCREASE THE HIGH FREQUENCY POWER COMPONENT OF HRV OR ANY OTHER CVD RISK FACTORS INVESTIGATED. AS REVEALED BY POST HOC ANALYSES, LOW ADHERENCE LIKELY CONTRIBUTED TO THE NULL EFFECTS. FUTURE STUDIES ARE REQUIRED TO ADDRESS BARRIERS TO ADHERENCE TO BETTER ELUCIDATE THE DOSE-RESPONSE EFFECTS OF BIKRAM YOGA PRACTICE AS A MEDIUM TO LOWER STRESS-RELATED CVD RISK. TRIAL REGISTRATION: RETROSPECTIVELY REGISTERED WITH AUSTRALIA NEW ZEALAND CLINICAL TRIALS REGISTRY ACTRN12616000867493 . REGISTERED 04 JULY 2016.	2017	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
10  451  43 CHANGES IN FATIGUE, AUTONOMIC FUNCTIONS, AND BLOOD BIOMARKERS DUE TO SITTING ISOMETRIC YOGA IN PATIENTS WITH CHRONIC FATIGUE SYNDROME. BACKGROUND: IN A PREVIOUS RANDOMIZED CONTROLLED TRIAL, WE FOUND THAT SITTING ISOMETRIC YOGA IMPROVES FATIGUE IN PATIENTS WITH CHRONIC FATIGUE SYNDROME (CFS) WHO ARE RESISTANT TO CONVENTIONAL THERAPY. THE AIM OF THIS STUDY WAS TO INVESTIGATE POSSIBLE MECHANISMS BEHIND THIS FINDING, FOCUSING ON THE SHORT-TERM FATIGUE-RELIEVING EFFECT, BY COMPARING AUTONOMIC NERVOUS FUNCTION AND BLOOD BIOMARKERS BEFORE AND AFTER A SESSION OF ISOMETRIC YOGA. METHODS: FIFTEEN PATIENTS WITH CFS WHO REMAINED SYMPTOMATIC DESPITE AT LEAST 6 MONTHS OF CONVENTIONAL THERAPY PRACTICED SITTING ISOMETRIC YOGA (BIWEEKLY 20 MIN PRACTICE WITH A YOGA INSTRUCTOR AND DAILY HOME PRACTICE) FOR EIGHT WEEKS. ACUTE EFFECTS OF SITTING ISOMETRIC YOGA ON FATIGUE, AUTONOMIC FUNCTION, AND BLOOD BIOMARKERS WERE INVESTIGATED AFTER THE FINAL SESSION WITH AN INSTRUCTOR. THE EFFECT OF A SINGLE SESSION OF SITTING ISOMETRIC YOGA ON FATIGUE WAS ASSESSED BY THE PROFILE OF MOOD STATUS (POMS) QUESTIONNAIRE IMMEDIATELY BEFORE AND AFTER THE SESSION. AUTONOMIC NERVOUS FUNCTION (HEART RATE (HR) VARIABILITY) AND BLOOD BIOMARKERS (CORTISOL, DHEA-S, TNF-ALPHA, IL-6, IFN-GAMMA, IFN-ALPHA, PROLACTIN, CARNITINE, TGF-BETA1, BDNF, MHPG, AND HVA) WERE COMPARED BEFORE AND AFTER THE SESSION. RESULTS: SITTING ISOMETRIC YOGA SIGNIFICANTLY REDUCED THE POMS FATIGUE SCORE (P < 0.01) AND INCREASED THE VIGOR SCORE (P < 0.01). IT ALSO REDUCED HR (P < 0.05) AND INCREASED THE HIGH FREQUENCY POWER (P < 0.05) OF HR VARIABILITY. SITTING ISOMETRIC YOGA INCREASED SERUM LEVELS OF DHEA-S (P < 0.05), REDUCED LEVELS OF CORTISOL (P < 0.05) AND TNF-ALPHA (P < 0.05), AND HAD A TENDENCY TO REDUCE SERUM LEVELS OF PROLACTIN (P < 0.1). DECREASES IN FATIGUE SCORES CORRELATED WITH CHANGES IN PLASMA LEVELS OF TGF-BETA1 AND BDNF. IN CONTRAST, INCREASED VIGOR POSITIVELY CORRELATED WITH HVA. CONCLUSIONS: A SINGLE SESSION OF SITTING ISOMETRIC YOGA REDUCED FATIGUE AND INCREASED VIGOR IN PATIENTS WITH CFS. YOGA ALSO INCREASED VAGAL NERVE FUNCTION AND CHANGED BLOOD BIOMARKERS IN A PATTERN THAT SUGGESTED ANTI-STRESS AND ANTI-INFLAMMATORY EFFECTS. THESE CHANGES APPEAR TO BE RELATED TO THE SHORT-TERM FATIGUE-RELIEVING EFFECT OF SITTING ISOMETRIC YOGA IN PATIENTS WITH CFS. FURTHERMORE, DOPAMINERGIC NERVOUS SYSTEM ACTIVATION MIGHT ACCOUNT FOR SITTING ISOMETRIC YOGA-INDUCED INCREASES IN ENERGY IN THIS PATIENT POPULATION. TRIAL REGISTRATION: UNIVERSITY HOSPITAL MEDICAL INFORMATION NETWORK (UMIN CTR) UMIN000009646. REGISTERED DEC 27, 2012.	2018	
                                                                                                                                                                                                                                                                                                                                                                                                                     
11 1359  44 IMMEDIATE EFFECTS OF OM CHANTING ON HEART RATE VARIABILITY MEASURES COMPARED BETWEEN EXPERIENCED AND INEXPERIENCED YOGA PRACTITIONERS. BACKGROUND: CHANTING "OM" IS A FORM OF MEDITATION THAT HAS NUMEROUS HEALTH BENEFITS. HOWEVER, THE NEUROPHYSIOLOGICAL MECHANISMS UNDERPINNING ITS EFFECT ARE SURPRISINGLY SCARCE. THE PRESENT STUDY AIMED TO INVESTIGATE THE EFFECT OF OM CHANTING ON AUTONOMIC MODULATION, USING HEART RATE VARIABILITY (HRV), ON EXPERIENCED YOGA PRACTITIONERS AND YOGA NAIVE PERSONS. METHODS: THIS PROSPECTIVE STUDY INCLUDED 19 YOGA PRACTITIONERS (9 FEMALES AND 10 MALES; GROUP MEAN AGE +/- STANDARD DEVIATION [SD]; 25.9 +/- 3.2 YEARS) AND 17 YOGA NAIVE PERSONS (8 FEMALES AND 9 MALES; GROUP MEAN AGE +/- SD; 24.8 +/- 3.6 YEARS) OF BOTH SEXES AND SIMILAR AGE RANGE. BOTH THE GROUPS WERE ASSESSED FOR HRV INDICES (TIME AND FREQUENCY DOMAIN MEASURES) BEFORE AND AFTER LOUD OM CHANTING FOR 5 MIN. RESULTS: BASELINE COMPARISON USING MANN-WHITNEY U TEST BETWEEN GROUPS SHOWED YOGA PRACTITIONERS HAD SIGNIFICANTLY INCREASED HIGH FREQUENCY (HF) POWER (P < 0.029) THAN NONYOGA PRACTITIONERS, SIGNIFYING A STATE OF TRANQUILITY BEFORE THE CHANTING OF OM. AFTER 5 MIN OF LOUD CHANTING OF OM, A COMPARISON BETWEEN GROUPS ASSESSED USING WILCOXON SIGNED RANKS TEST REVEALED: HF POWER, A COMPONENT OF THE PARASYMPATHETIC NERVOUS SYSTEM, WAS FURTHER AMPLIFIED WITH A SIGNIFICANTLY INCREASE (P < 0.001) IN THE YOGA PRACTITIONERS GROUP COMPARED TO NONYOGA PRACTITIONERS. FURTHERMORE, THIS INCREASE IN HF POWER WAS POSITIVELY CORRELATED WITH THE YEARS OF EXPERIENCE IN YOGA. CONCLUSION: THE PRESENT STUDY SHOWED THAT A BRIEF CHANTING OF OM (5 MIN) MIGHT ENHANCE PARASYMPATHETIC NERVOUS SYSTEM ACTIVITY, PROMOTE RELAXATION, AND PROVIDE CALMNESS. FURTHER, THIS EXPERIENCE MAY BE ACHIEVED EFFECTIVELY IN INDIVIDUALS EXPERIENCED IN YOGA THAN NONYOGA PRACTITIONERS.	2022	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
12 1558  37 LONG-TERM EFFECTS OF HATHA YOGA ON HEART RATE VARIABILITY IN HEALTHY PRACTITIONERS: POTENTIAL BENEFITS FOR CARDIOVASCULAR RISK REDUCTION. HATHA YOGA IS COMMONLY PRACTICED IN WESTERN COUNTRIES AND IS CLAIMED TO REDUCE RISK OF CARDIOVASCULAR DISEASE. THE PURPOSE OF THIS STUDY WAS TO EVALUATE AND COMPARE TIME-DOMAIN AND FREQUENCY-DOMAIN METRICS OF HEART RATE VARIABILITY (HRV) IN HATHA YOGA PRACTITIONERS AND HEALTHY CONTROLS. THIS CROSS-SECTIONAL STUDY, WHICH WAS CONDUCTED AT A REGIONAL UNIVERSITY AND COMMUNITY WELLNESS CENTER, INCLUDED CONVENIENCE SAMPLING OF 19 HATHA YOGA PRACTITIONERS AND 8 HEALTHY CONTROLS. USING A LEAD II ECG SYSTEM, 10 MINUTES OF ELECTROCARDIOGRAM (ECG) RECORDING WAS COLLECTED FOR EACH PARTICIPANT. ARTIFACT-FREE, 5-MINUTE SIGNALS WERE USED TO DERIVE TIME-DOMAIN AND FREQUENCY-DOMAIN MEASURES OF HRV. THE MEAN DURATION OF HATHA YOGA PRACTICE AMONG PRACTITIONERS WAS 11.47 +/- 8 YEARS. DEMOGRAPHIC AND ANTHROPOMETRIC CHARACTERISTICS DID NOT DIFFER SIGNIFICANTLY BETWEEN GROUPS. COMPARED WITH THE CONTROL GROUP, THE YOGA GROUP HAD SIGNIFICANTLY GREATER MEAN HIGH FREQUENCY (HF) POWER (859.2 +/- 1342.1 VS 175.5 +/- 121.1; P = .04) AND MEAN HF NORMALIZED UNITS (NU) (57.0 +/- 16.6 VS 36.7 +/- 13.4; P = .02) AND A SIGNIFICANTLY LOWER LOW FREQUENCY (LF)/HF RATIO (1.1 +/- 0.5 VS 2.2 +/- 1.1; P = .01). NO SIGNIFICANT INTERGROUP DIFFERENCES WERE OBSERVED FOR LF POWER, LF NU, OR ANY TIME-DOMAIN MEASURES OF HRV. THESE RESULTS LACK GENERALIZABILITY DUE TO SMALL SAMPLE SIZE AND LACK OF BLINDED ASSESSMENT OF OUTCOME MEASURES. HATHA YOGA PRACTITIONERS SHOWED PARASYMPATHETIC PREDOMINANCE COMPARED WITH HEALTHY CONTROLS. ANALYZING FREQUENCY-DOMAIN HRV METRICS ENABLES DETECTING CHANGES IN CARDIAC AUTONOMIC FUNCTION EARLIER THAN BY ANALYSIS OF TIME-DOMAIN METRICS. PARASYMPATHETIC PREDOMINANCE DEMONSTRATED IN THE YOGA GROUP SUGGESTS HATHA YOGA PRACTITIONERS MAY BE AT LOWER RISK FOR STRESS-RELATED COMORBIDITIES.	2021	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
13  984  48 EFFECTS OF HATHA YOGA AND AFRICAN DANCE ON PERCEIVED STRESS, AFFECT, AND SALIVARY CORTISOL. BACKGROUND: DANCE AND YOGA HAVE BEEN SHOWN TO PRODUCE IMPROVEMENTS IN PSYCHOLOGICAL WELL-BEING. PURPOSE: THE AIM OF THIS STUDY WAS TO EXAMINE SOME OF THE PSYCHOLOGICAL AND NEUROENDOCRINE RESPONSE TO THESE ACTIVITIES. METHODS: SIXTY-NINE HEALTHY COLLEGE STUDENTS PARTICIPATED IN ONE OF THREE 90-MIN CLASSES: AFRICAN DANCE (N = 21), HATHA YOGA (N= 18), OR A BIOLOGY LECTURE AS A CONTROL SESSION (N = 30). BEFORE AND AFTER EACH CONDITION PARTICIPANTS COMPLETED THE PERCEIVED STRESS SCALE (PSS), COMPLETED THE POSITIVE AFFECT AND NEGATIVE AFFECT SCHEDULE, AND PROVIDED A SALIVA SAMPLE FOR CORTISOL. RESULTS: THERE WERE SIGNIFICANT REDUCTIONS IN PSS AND NEGATIVE AFFECT (PS < .0001) AND TIME X TREATMENT INTERACTIONS (PS < .0001) SUCH THAT AFRICAN DANCE AND HATHA YOGA SHOWED SIGNIFICANT DECLINES, WHEREAS THERE WAS NO SIGNIFICANT CHANGE IN BIOLOGY LECTURE. THERE WAS NO SIGNIFICANT MAIN EFFECT FOR POSITIVE AFFECT (P = .53), HOWEVER THERE WAS A SIGNIFICANT INTERACTION EFFECT (P < .001) SUCH THAT POSITIVE AFFECT INCREASED IN AFRICAN DANCE, DECREASED IN BIOLOGY LECTURE, AND DID NOT CHANGE SIGNIFICANTLY IN HATHA YOGA. THERE WAS A SIGNIFICANT MAIN EFFECT FOR SALIVARY CORTISOL (P < .05) AND A SIGNIFICANT INTERACTION EFFECT (P < .0001) SUCH THAT CORTISOL INCREASED IN AFRICAN DANCE, DECREASED IN HATHA YOGA, AND DID NOT CHANGE IN BIOLOGY. CHANGES IN CORTISOL WERE NOT SIGNIFICANTLY RELATED TO CHANGES IN PSYCHOLOGICAL VARIABLES ACROSS TREATMENTS. THERE WAS 1 SIGNIFICANT INTERACTION EFFECT (P = .04) SUCH THAT CHANGE IN POSITIVE AFFECT AND CHANGE IN CORTISOL WERE NEGATIVELY CORRELATED IN HATHA YOGA BUT POSITIVELY CORRELATED IN AFRICA DANCE AND BIOLOGY. CONCLUSIONS: BOTH AFRICAN DANCE AND HATHA YOGA REDUCED PERCEIVED STRESS AND NEGATIVE AFFECT. CORTISOL INCREASED IN AFRICAN DANCE AND DECREASED IN HATHA YOGA. THEREFORE, EVEN WHEN THESE INTERVENTIONS PRODUCE SIMILAR POSITIVE PSYCHOLOGICAL EFFECTS, THE EFFECTS MAY BE VERY DIFFERENT ON PHYSIOLOGICAL STRESS PROCESSES. ONE FACTOR THAT MAY HAVE PARTICULAR SALIENCE IS THAT AMOUNT OF PHYSIOLOGICAL AROUSAL PRODUCED BY THE INTERVENTION.	2004	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
14 2648  29 YOGA HELPS PUT THE PIECES BACK TOGETHER: A QUALITATIVE EXPLORATION OF A COMMUNITY-BASED YOGA PROGRAM FOR CANCER SURVIVORS. OBJECTIVE. A QUALITATIVE RESEARCH METHODS APPROACH WAS USED TO EXPLORE THE EXPERIENCES OF PARTICIPANTS IN AN ONGOING COMMUNITY-BASED YOGA PROGRAM DEVELOPED FOR CANCER SURVIVORS AND THEIR SUPPORT PERSONS. METHODS. 25 PARTICIPANTS TOOK PART IN A SERIES OF SEMISTRUCTURED FOCUS GROUPS FOLLOWING A SEVEN-WEEK YOGA PROGRAM AND AT THREE- AND SIX-MONTH FOLLOW-UPS. FOCUS GROUPS WERE TRANSCRIBED VERBATIM AND ANALYZED USING A PROCESS OF INDUCTIVE THEMATIC ANALYSIS. RESULTS. THE GROUP WAS COMPRISED OF 20 CANCER SURVIVORS, WHO WERE DIAGNOSED ON AVERAGE 25.40 (20.85) MONTHS EARLIER, AND FIVE SUPPORT PERSONS. PARTICIPANTS HAD COMPLETED THE YOGA PROGRAM AN AVERAGE OF 3.35 (3.66) TIMES PREVIOUSLY AND ATTENDED APPROXIMATELY 1.64 (0.70) OF THREE POSSIBLE FOCUS GROUPS. FOUR KEY THEMES WERE IDENTIFIED: (1) SAFETY AND SHARED UNDERSTANDING; (2) CANCER-SPECIFIC YOGA INSTRUCTION; (3) BENEFITS OF YOGA PARTICIPATION; (4) MECHANISMS OF YOGA PRACTICE. CONCLUSIONS. QUALITATIVE RESEARCH PROVIDES UNIQUE AND IN-DEPTH INSIGHT INTO THE YOGA EXPERIENCE. SPECIFICALLY, CANCER SURVIVORS AND SUPPORT PERSONS PARTICIPATING IN A COMMUNITY-BASED YOGA PROGRAM DISCUSSED THEIR EXPERIENCES OF CHANGE OVER TIME AND WERE ACUTELY AWARE OF THE BENEFICIAL EFFECTS OF YOGA ON THEIR PHYSICAL, PSYCHOLOGICAL, AND SOCIAL WELL-BEING. FURTHER, PARTICIPANTS WERE ABLE TO ARTICULATE THE MECHANISMS THEY PERCEIVED AS UNDERPINNING THE RELATIONSHIP BETWEEN YOGA AND IMPROVED WELL-BEING AS THEY DEVELOPED THEIR YOGA PRACTICE.	2016	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
15  990  37 EFFECTS OF HATHA YOGA ON STRESS IN MIDDLE-AGED WOMEN. BACKGROUND: STRESS IS CONSIDERED A CRUCIAL TRIGGER FOR PHYSICAL AND MENTAL ILLNESS. STRESS REDUCTION IS A KNOWN LONG-TERM BENEFIT OF REGULAR HATHA YOGA PRACTICE. THE EFFICACY OF A SINGLE-SESSION HATHA YOGA CLASS ON STRESS REDUCTION IS NOT CURRENTLY KNOWN. PURPOSE: THIS STUDY INVESTIGATED THE COMPARATIVE EFFECTIVENESS OF A SINGLE 90-MINUTE HATHA YOGA CLASS AND AN 8-WEEK, 90-MINUTE-CLASS-PER-WEEK COURSE. METHODS: WE USED A QUASIEXPERIMENTAL DESIGN AND RECRUITED 63 FEMALE COMMUNITY RESIDENTS IN NEW TAIPEI CITY AGED 40-60 YEARS. PARTICIPANTS WERE RANDOMLY DIVIDED INTO AN EXPERIMENTAL GROUP (N = 30) AND A CONTROL GROUP (N = 33). THE EXPERIMENTAL GROUP RECEIVED THE 8-WEEK HATHA YOGA COURSE. THE CONTROL GROUP RECEIVED NO INTERVENTION. THE PERCEIVED STRESS SCALE (PSS) AND HEART RATE VARIABILITY (HRV) ASSESSED STRESS REDUCTION EFFECTIVENESS. CHI-SQUARE, INDEPENDENT T TEST, PAIRED T TEST, AND GENERALIZED ESTIMATING EQUATIONS WERE USED FOR DATA ANALYSIS. RESULTS: AFTER A SINGLE 90-MINUTE CLASS OF HATHA YOGA, EXPERIMENTAL GROUP PSS SCORES WERE SIGNIFICANTLY LESS THAN THOSE OF THE CONTROL GROUP (P = .001). ALTHOUGH EXPERIMENTAL GROUP HRV (LOW-FREQUENCY NORM AND HIGH-FREQUENCY NORM) HAD IMPROVED, THESE CHANGES WERE NOT STATISTICALLY SIGNIFICANT (P = .059). PSS SCORES FOR THE SINGLE 90-MINUTE CLASS AND 8-WEEK COURSE DID NOT SIGNIFICANTLY DIFFER (P = .157) AND HRV OF STATISTICS IS SIGNIFICANT (P = .005). GENERALIZED ESTIMATING EQUATIONS ANALYZED CHANGES IN THE EFFECTIVENESS OVER TIME OF STRESS REDUCTION (HRV AND PSS) AFTER THE HATHA YOGA INTERVENTION. RESULTS SHOWED THE POSTINTERVENTION HRV AND PSS OF THE EXPERIMENTAL GROUP DECREASED SIGNIFICANTLY (P < .001) MORE THAN THE CONTROL GROUP. CONCLUSIONS/IMPLICATIONS FOR PRACTICE: OUR FINDINGS SUPPORT THE POSITION THAT REGULAR, LONG-TERM PRACTICE OF HATHA YOGA PROVIDES CLEAR AND SIGNIFICANT HEALTH BENEFITS. PARTICIPATION IN A SINGLE 90-MINUTE HATHA YOGA CLASS CAN SIGNIFICANTLY REDUCE PERCEIVED STRESS. DOING HATHA YOGA REGULARLY CAN REDUCE PERCEIVED STRESS EVEN MORE SIGNIFICANTLY.	2013	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
16 1063  45 EFFECTS OF YOGA ON HEART RATE VARIABILITY AND MOOD IN WOMEN: A RANDOMIZED CONTROLLED TRIAL. OBJECTIVE: TO EXAMINE THE EFFECTS OF AN 8-WEEK YOGA PROGRAM ON HEART RATE VARIABILITY AND MOOD IN GENERALLY HEALTHY WOMEN. DESIGN: RANDOMIZED CONTROLLED TRIAL. PARTICIPANTS: FIFTY-TWO HEALTHY WOMEN WERE RANDOMLY ASSIGNED TO A YOGA GROUP OR A CONTROL GROUP. INTERVENTIONS: PARTICIPANTS IN THE YOGA GROUP COMPLETED AN 8-WEEK YOGA PROGRAM, WHICH COMPRISED A 60-MINUTE SESSION TWICE A WEEK. EACH SESSION CONSISTED OF BREATHING EXERCISES, YOGA POSE PRACTICE, AND SUPINE MEDITATION/RELAXATION. THE CONTROL GROUP WAS INSTRUCTED NOT TO ENGAGE IN ANY YOGA PRACTICE AND TO MAINTAIN THEIR USUAL LEVEL OF PHYSICAL ACTIVITY DURING THE STUDY. OUTCOME MEASURES: PARTICIPANTS' HEART RATE VARIABILITY, PERCEIVED STRESS, DEPRESSIVE SYMPTOMS, AND STATE AND TRAIT ANXIETY WERE ASSESSED AT BASELINE (WEEK 0) AND AFTER THE INTERVENTION (WEEK 9). RESULTS: NO MEASURES OF HEART RATE VARIABILITY CHANGED SIGNIFICANTLY IN EITHER THE YOGA OR CONTROL GROUP AFTER INTERVENTION. STATE ANXIETY WAS REDUCED SIGNIFICANTLY IN THE YOGA GROUP BUT NOT IN THE CONTROL GROUP. NO SIGNIFICANT CHANGES WERE NOTED IN PERCEIVED STRESS, DEPRESSION, OR TRAIT ANXIETY IN EITHER GROUP. CONCLUSIONS: AN 8-WEEK YOGA PROGRAM WAS NOT SUFFICIENT TO IMPROVE HEART RATE VARIABILITY. HOWEVER, SUCH A PROGRAM APPEARS TO BE EFFECTIVE IN REDUCING STATE ANXIETY IN GENERALLY HEALTHY WOMEN. FUTURE RESEARCH SHOULD INVOLVE LONGER PERIODS OF YOGA TRAINING, INCLUDE HEART RATE VARIABILITY MEASURES BOTH AT REST AND DURING YOGA PRACTICE, AND ENROLL WOMEN WITH HIGHER LEVELS OF STRESS AND TRAIT ANXIETY.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
17  687  50 EFFECT OF AN OFFICE WORKSITE-BASED YOGA PROGRAM ON HEART RATE VARIABILITY: OUTCOMES OF A RANDOMIZED CONTROLLED TRIAL. BACKGROUND: CHRONIC WORK-RELATED STRESS IS AN INDEPENDENT RISK FACTOR FOR CARDIOMETABOLIC DISEASES AND ASSOCIATED MORTALITY, PARTICULARLY WHEN COMPOUNDED BY A SEDENTARY WORK ENVIRONMENT. THE PURPOSE OF THIS STUDY WAS TO DETERMINE IF AN OFFICE WORKSITE-BASED HATHA YOGA PROGRAM COULD IMPROVE PHYSIOLOGICAL STRESS, EVALUATED VIA HEART RATE VARIABILITY (HRV), AND ASSOCIATED HEALTH-RELATED OUTCOMES IN A COHORT OF OFFICE WORKERS. METHODS: THIRTY-SEVEN ADULTS EMPLOYED IN UNIVERSITY-BASED OFFICE POSITIONS WERE RANDOMIZED UPON THE COMPLETION OF BASELINE TESTING TO AN EXPERIMENTAL OR CONTROL GROUP. THE EXPERIMENTAL GROUP COMPLETED A 10-WEEK YOGA PROGRAM PRESCRIBED THREE SESSIONS PER WEEK DURING LUNCH HOUR (50 MIN PER SESSION). AN EXPERIENCED INSTRUCTOR LED THE SESSIONS, WHICH EMPHASIZED ASANAS (POSTURES) AND VINYASA (EXERCISES). THE PRIMARY OUTCOME WAS THE HIGH FREQUENCY (HF) POWER COMPONENT OF HRV. SECONDARY OUTCOMES INCLUDED ADDITIONAL HRV PARAMETERS, MUSCULOSKELETAL FITNESS (I.E. PUSH-UP, SIDE-BRIDGE, AND SIT & REACH TESTS) AND PSYCHOLOGICAL INDICES (I.E. STATE AND TRAIT ANXIETY, QUALITY OF LIFE AND JOB SATISFACTION). RESULTS: ALL MEASURES OF HRV FAILED TO CHANGE IN THE EXPERIMENTAL GROUP VERSUS THE CONTROL GROUP, EXCEPT THAT THE EXPERIMENTAL GROUP SIGNIFICANTLY INCREASED LF:HF (P = 0.04) AND REDUCED PNN50 (P = 0.04) VERSUS CONTROL, CONTRARY TO OUR HYPOTHESES. FLEXIBILITY, EVALUATED VIA SIT & REACH TEST INCREASED IN THE EXPERIMENTAL GROUP VERSUS THE CONTROL GROUP (P < 0.001). NO OTHER ADAPTATIONS WERE NOTED. POST HOC ANALYSIS COMPARING PARTICIPANTS WHO COMPLETED >/=70% OF YOGA SESSIONS (N = 11) TO CONTROL (N = 19) YIELDED THE SAME FINDINGS, EXCEPT THAT THE HIGH ADHERERS ALSO REDUCED STATE ANXIETY (P = 0.02) AND RMSSD (P = 0.05), AND TENDED TO IMPROVE THE PUSH-UP TEST (P = 0.07) VERSUS CONTROL. CONCLUSIONS: A 10-WEEK HATHA YOGA INTERVENTION DELIVERED AT THE OFFICE WORKSITE DURING LUNCH HOUR DID NOT IMPROVE HF POWER OR OTHER HRV PARAMETERS. HOWEVER, IMPROVEMENTS IN FLEXIBILITY, STATE ANXIETY AND MUSCULOSKELETAL FITNESS WERE NOTED WITH HIGH ADHERENCE. FUTURE INVESTIGATIONS SHOULD INCORPORATE STRATEGIES TO PROMOTE ADHERENCE, INVOLVE MORE FREQUENT AND LONGER DURATIONS OF YOGA TRAINING, AND ENROL COHORTS WHO SUFFER FROM HIGHER LEVELS OF WORK-RELATED STRESS. TRIAL REGISTRATION: ACTRN12611000536965.	2013	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
18 2250  50 THE LONGITUDINAL EFFECTS OF SEATED ISOMETRIC YOGA ON BLOOD BIOMARKERS, AUTONOMIC FUNCTIONS, AND PSYCHOLOGICAL PARAMETERS OF PATIENTS WITH CHRONIC FATIGUE SYNDROME: A PILOT STUDY. BACKGROUND: IN A PREVIOUS RANDOMIZED CONTROLLED TRIAL, WE FOUND THAT PRACTICING SEATED ISOMETRIC YOGA REGULARLY FOR 2 MONTHS IMPROVED THE FATIGUE OF PATIENTS WITH CHRONIC FATIGUE SYNDROME (CFS) WHO ARE RESISTANT TO CONVENTIONAL THERAPY. THE AIM OF THIS PILOT STUDY WAS TO INVESTIGATE THE POSSIBLE MECHANISMS BEHIND THIS FINDING BY COMPARING BLOOD BIOMARKERS, AUTONOMIC NERVOUS FUNCTION, AND PSYCHOLOGICAL INDICES BEFORE VERSUS AFTER AN INTERVENTION PERIOD OF SEATED ISOMETRIC YOGA PRACTICE. METHODS: FIFTEEN PATIENTS WITH CFS WHO DID NOT SHOW SATISFACTORY IMPROVEMENTS AFTER AT LEAST 6 MONTHS OF CONVENTIONAL THERAPY PRACTICED SEATED ISOMETRIC YOGA (BIWEEKLY 20-MIN SESSIONS WITH A YOGA INSTRUCTOR AND DAILY PRACTICE AT HOME) FOR 2 MONTHS. THE LONGITUDINAL EFFECTS OF SEATED ISOMETRIC YOGA ON FATIGUE, BLOOD BIOMARKERS, AUTONOMIC FUNCTION, AND PSYCHOLOGICAL STATE WERE INVESTIGATED BY COMPARING THE FOLLOWING PARAMETERS BEFORE AND AFTER THE INTERVENTION PERIOD: FATIGUE SEVERITY WAS ASSESSED BY THE CHALDER FATIGUE SCALE (FS) SCORE. LEVELS OF THE BLOOD BIOMARKERS CORTISOL, DHEA-S, TNF-ALPHA, IL-6, PROLACTIN, CARNITINE, TGF-BETA1, BDNF, MHPG, HVA, AND ALPHA-MSH WERE MEASURED. THE AUTONOMIC NERVOUS FUNCTIONS ASSESSED WERE HEART RATE (HR) AND HR VARIABILITY. PSYCHOLOGICAL INDICES INCLUDED THE 20-ITEM TORONTO ALEXITHYMIA SCALE (TAS-20) AND THE HOSPITAL ANXIETY AND DEPRESSION SCALE (HADS). RESULTS: PRACTICING SEATED ISOMETRIC YOGA FOR 2 MONTHS RESULTED IN SIGNIFICANT REDUCTIONS IN THE CHALDER FS (P = 0.002) AND HADS-DEPRESSION (P = 0.02) SCORES. NO SIGNIFICANT CHANGES WERE OBSERVED IN ANY OTHER PARAMETER EVALUATED. THE CHANGE IN CHALDER FS SCORE WAS NOT CORRELATED WITH THE CHANGE IN HADS-DEPRESSION SCORE. HOWEVER, THIS CHANGE WAS POSITIVELY CORRELATED WITH CHANGES IN THE SERUM TNF-ALPHA LEVELS (P = 0.048), THE HIGH FREQUENCY COMPONENT OF HR VARIABILITY (P = 0.042), AND TAS-20 SCORES (P = 0.001). CONCLUSIONS: REGULAR PRACTICE OF SEATED ISOMETRIC YOGA FOR 2 MONTHS REDUCED THE FATIGUE AND DEPRESSIVE SYMPTOM SCORES OF PATIENTS WITH CFS WITHOUT AFFECTING ANY OTHER PARAMETERS WE INVESTIGATED. THIS STUDY FAILED TO IDENTIFY THE MARKERS RESPONSIBLE FOR THE LONGITUDINAL FATIGUE-RELIEVING EFFECT OF SEATED ISOMETRIC YOGA. HOWEVER, CONSIDERING THAT THE REDUCED FATIGUE WAS ASSOCIATED WITH DECREASED SERUM TNF-ALPHA LEVEL AND TAS-20 SCORES, FATIGUE IMPROVEMENT MIGHT BE RELATED TO REDUCED INFLAMMATION AND IMPROVED ALEXITHYMIA IN THESE PATIENTS. TRIAL REGISTRATION: UNIVERSITY HOSPITAL MEDICAL INFORMATION NETWORK (UMIN CTR) UMIN000009646. REGISTERED DEC 27, 2012.	2019	
                                                                                                                                                                                                                                                                   
19 2836  34 YOGA'S IMPACT ON INFLAMMATION, MOOD, AND FATIGUE IN BREAST CANCER SURVIVORS: A RANDOMIZED CONTROLLED TRIAL. PURPOSE: TO EVALUATE YOGA'S IMPACT ON INFLAMMATION, MOOD, AND FATIGUE. PATIENTS AND METHODS: A RANDOMIZED CONTROLLED 3-MONTH TRIAL WAS CONDUCTED WITH TWO POST-TREATMENT ASSESSMENTS OF 200 BREAST CANCER SURVIVORS ASSIGNED TO EITHER 12 WEEKS OF 90-MINUTE TWICE PER WEEK HATHA YOGA CLASSES OR A WAIT-LIST CONTROL. THE MAIN OUTCOME MEASURES WERE LIPOPOLYSACCHARIDE-STIMULATED PRODUCTION OF PROINFLAMMATORY CYTOKINES INTERLEUKIN-6 (IL-6), TUMOR NECROSIS FACTOR ALPHA (TNF-ALPHA), AND INTERLEUKIN-1BETA (IL-1BETA), AND SCORES ON THE MULTIDIMENSIONAL FATIGUE SYMPTOM INVENTORY-SHORT FORM (MFSI-SF), THE VITALITY SCALE FROM THE MEDICAL OUTCOMES STUDY 36-ITEM SHORT FORM (SF-36), AND THE CENTER FOR EPIDEMIOLOGICAL STUDIES-DEPRESSION (CES-D) SCALE. RESULTS: IMMEDIATELY POST-TREATMENT, FATIGUE WAS NOT LOWER (P > .05) BUT VITALITY WAS HIGHER (P = .01) IN THE YOGA GROUP COMPARED WITH THE CONTROL GROUP. AT 3 MONTHS POST-TREATMENT, FATIGUE WAS LOWER IN THE YOGA GROUP (P = .002), VITALITY WAS HIGHER (P = .01), AND IL-6 (P = .027), TNF-ALPHA (P = .027), AND IL-1BETA (P = .037) WERE LOWER FOR YOGA PARTICIPANTS COMPARED WITH THE CONTROL GROUP. GROUPS DID NOT DIFFER ON DEPRESSION AT EITHER TIME (P > .2). PLANNED SECONDARY ANALYSES SHOWED THAT THE FREQUENCY OF YOGA PRACTICE HAD STRONGER ASSOCIATIONS WITH FATIGUE AT BOTH POST-TREATMENT VISITS (P = .019; P < .001), AS WELL AS VITALITY (P = .016; P = .0045), BUT NOT DEPRESSION (P > .05) THAN SIMPLE GROUP ASSIGNMENT; MORE FREQUENT PRACTICE PRODUCED LARGER CHANGES. AT 3 MONTHS POST-TREATMENT, INCREASING YOGA PRACTICE ALSO LED TO A DECREASE IN IL-6 (P = .01) AND IL-1BETA (P = .03) PRODUCTION BUT NOT IN TNF-ALPHA PRODUCTION (P > .05). CONCLUSION: CHRONIC INFLAMMATION MAY FUEL DECLINES IN PHYSICAL FUNCTION LEADING TO FRAILTY AND DISABILITY. IF YOGA DAMPENS OR LIMITS BOTH FATIGUE AND INFLAMMATION, THEN REGULAR PRACTICE COULD HAVE SUBSTANTIAL HEALTH BENEFITS.	2014	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
20 1318  50 HEART RATE VARIABILITY IN CHRONIC LOW BACK PAIN PATIENTS RANDOMIZED TO YOGA OR STANDARD CARE. BACKGROUND: CHRONIC PAIN CAN ALTER THE AUTONOMIC BALANCE WITH INCREASED SYMPATHETIC ACTIVITY REFLECTED IN ALTERED HEART RATE VARIABILITY (HRV). IT HAS BEEN PROPOSED THAT YOGA CAN BE USEFUL TO CORRECT THE AUTONOMIC IMBALANCE IN PATIENTS WITH CHRONIC PAIN WHO HAVE REDUCED HRV. METHODS AND DESIGNS: IN THE PRESENT RANDOMIZED CONTROLLED TRIAL 62 PATIENTS WITH CHRONIC LOW BACK PAIN ASSOCIATED WITH ALTERED ALIGNMENT OF INTERVERTEBRAL DISCS (AGED BETWEEN 20 AND 45 YEARS, 32 MALES) WERE RANDOMIZED TO 2 GROUPS. ONE GROUP RECEIVED YOGA FOR 3 MONTHS WHILE THE OTHER GROUP CARRIED OUT STANDARD MEDICAL CARE BASED ON THE PHYSICIAN'S ADVICE. THE DURATION WAS THE SAME, I.E., 3 MONTHS. THE HEART RATE VARIABILITY AND RATE OF RESPIRATION WERE ASSESSED AT BASELINE AND AT THE END OF 3 MONTHS. RESULTS: THERE WAS A SIGNIFICANT DIFFERENCE IN THE BASELINE (PRE) VALUES BETWEEN GROUPS (P = 0.008) FOR RESPIRATION RATE WHICH WAS HIGHER IN THE YOGA GROUP. THE CHANGES REPORTED BELOW ARE PRE-POST COMPARISONS WITHIN EACH GROUP. THE YOGA GROUP SHOWED A SIGNIFICANT (P < 0.05; REPEATED MEASURES ANOVA, POST-HOC ANALYSES) DECREASE IN THE LF POWER OF HRV, RATE OF RESPIRATION AND A SIGNIFICANT INCREASE IN THE HF POWER OF HRV AND IN THE PNN50. CONCLUSION: THE RESULTS SUGGEST THAT YOGA PRACTICE CAN SHIFT THE AUTONOMIC BALANCE TOWARDS VAGAL DOMINANCE IN PATIENTS WITH CHRONIC LOW BACK PAIN ASSOCIATED WITH ALTERED ALIGNMENT OF INTERVERTEBRAL DISCS. TRIAL REGISTRATION: THE STUDY IS REGISTERED WITH THE CLINICAL TRIALS REGISTRY OF INDIA ( CTRI/2012/11/003094 ) AND CAN BE ACCESSED AT.	2016