1 2093 126 THE EFFECT OF YOCAS(C)(R) YOGA FOR MUSCULOSKELETAL SYMPTOMS AMONG BREAST CANCER SURVIVORS ON HORMONAL THERAPY. UP TO 50% OF BREAST CANCER SURVIVORS ON AROMATASE INHIBITOR THERAPY REPORT MUSCULOSKELETAL SYMPTOMS SUCH AS JOINT AND MUSCLE PAIN, SIGNIFICANTLY IMPACTING TREATMENT ADHERENCE AND DISCONTINUATION RATES. WE CONDUCTED A SECONDARY DATA ANALYSIS OF A NATIONWIDE, MULTI-SITE, PHASE II/III RANDOMIZED, CONTROLLED, CLINICAL TRIAL EXAMINING THE EFFICACY OF YOGA FOR IMPROVING MUSCULOSKELETAL SYMPTOMS AMONG BREAST CANCER SURVIVORS CURRENTLY RECEIVING HORMONE THERAPY (AROMATASE INHIBITORS [AI] OR TAMOXIFEN [TAM]). BREAST CANCER SURVIVORS CURRENTLY RECEIVING AI (N = 95) OR TAM (N = 72) WITH NO PARTICIPATION IN YOGA DURING THE PREVIOUS 3 MONTHS WERE RANDOMIZED INTO 2 ARMS: (1) STANDARD CARE MONITORING AND (2) STANDARD CARE PLUS THE 4-WEEK YOGA INTERVENTION (2X/WEEK; 75 MIN/SESSION) AND INCLUDED IN THIS ANALYSIS. THE YOGA INTERVENTION UTILIZED THE UR YOGA FOR CANCER SURVIVORS (YOCAS(C)((R))) PROGRAM CONSISTING OF BREATHING EXERCISES, 18 GENTLE HATHA AND RESTORATIVE YOGA POSTURES, AND MEDITATION. MUSCULOSKELETAL SYMPTOMS WERE ASSESSED PRE- AND POST-INTERVENTION. AT BASELINE, AI USERS REPORTED HIGHER LEVELS OF GENERAL PAIN, MUSCLE ACHES, AND TOTAL PHYSICAL DISCOMFORT THAN TAM USERS (ALL P </= 0.05). AMONG ALL BREAST CANCER SURVIVORS ON HORMONAL THERAPY, PARTICIPANTS IN THE YOGA GROUP DEMONSTRATED GREATER REDUCTIONS IN MUSCULOSKELETAL SYMPTOMS SUCH AS GENERAL PAIN, MUSCLE ACHES AND TOTAL PHYSICAL DISCOMFORT FROM PRE- TO POST-INTERVENTION THAN THE CONTROL GROUP (ALL P </= 0.05). THE SEVERITY OF MUSCULOSKELETAL SYMPTOMS WAS HIGHER FOR AI USERS COMPARED TO TAM USERS. AMONG BREAST CANCER SURVIVORS ON HORMONE THERAPY, THE BRIEF COMMUNITY-BASED YOCAS(C)(R) INTERVENTION SIGNIFICANTLY REDUCED GENERAL PAIN, MUSCLE ACHES, AND PHYSICAL DISCOMFORT.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
2 1052  48 EFFECTS OF YOGA ON CANCER-RELATED FATIGUE AND GLOBAL SIDE-EFFECT BURDEN IN OLDER CANCER SURVIVORS. BACKGROUND: SIXTY PERCENT OF CANCER SURVIVORS ARE 65YEARS OF AGE OR OLDER. CANCER AND ITS TREATMENTS LEAD TO CANCER-RELATED FATIGUE AND MANY OTHER SIDE EFFECTS, IN TURN, CREATING SUBSTANTIAL GLOBAL SIDE-EFFECT BURDEN (TOTAL BURDEN FROM ALL SIDE EFFECTS) WHICH, ULTIMATELY, COMPROMISES FUNCTIONAL INDEPENDENCE AND QUALITY OF LIFE. VARIOUS MODES OF EXERCISE, SUCH AS YOGA, REDUCE CANCER-RELATED FATIGUE AND GLOBAL SIDE-EFFECT BURDEN IN YOUNGER CANCER SURVIVORS, BUT NO STUDIES HAVE SPECIFICALLY EXAMINED THE EFFECTS OF YOGA ON OLDER CANCER SURVIVORS. OBJECTIVES: THE PURPOSE OF THIS STUDY WAS TO ASSESS THE EFFECTS OF A 4-WEEK YOGA INTERVENTION (YOGA FOR CANCER SURVIVORS: YOCAS(C)(R)) ON OVERALL CANCER-RELATED FATIGUE, AND DUE TO ITS MULTIDIMENSIONAL NATURE, THE SUBDOMAINS OF CANCER-RELATED FATIGUE (GENERAL, PHYSICAL, EMOTIONAL, AND MENTAL) AND GLOBAL SIDE-EFFECT BURDEN IN OLDER CANCER SURVIVORS. MATERIALS AND METHODS: WE CONDUCTED A SECONDARY ANALYSIS ON DATA FROM A MULTICENTER PHASE III RANDOMIZED CONTROLLED CLINICAL TRIAL WITH 2 ARMS (STANDARD CARE AND STANDARD CARE PLUS A 4-WEEK YOCAS(C)(R) INTERVENTION). THE SAMPLE FOR THIS SECONDARY ANALYSIS WAS 97 OLDER CANCER SURVIVORS (>/=60YEARS OF AGE), BETWEEN 2MONTHS AND 2YEARS POST-TREATMENT, WHO PARTICIPATED IN THE ORIGINAL TRIAL. RESULTS: PARTICIPANTS IN THE YOCAS(C)(R) INTERVENTION ARM REPORTED SIGNIFICANTLY LOWER CANCER-RELATED FATIGUE, PHYSICAL FATIGUE, MENTAL FATIGUE, AND GLOBAL SIDE-EFFECT BURDEN THAN PARTICIPANTS IN THE STANDARD CARE ARM FOLLOWING THE 4-WEEK INTERVENTION PERIOD (P<0.05). CONCLUSIONS: YOCAS(C)(R) IS AN EFFECTIVE STANDARDIZED YOGA INTERVENTION FOR REDUCING CANCER-RELATED FATIGUE, PHYSICAL FATIGUE, MENTAL FATIGUE, AND GLOBAL SIDE-EFFECT BURDEN AMONG OLDER CANCER SURVIVORS.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
3  428  40 CAN YOGA HAVE ANY EFFECT ON SHOULDER AND ARM PAIN AND QUALITY OF LIFE IN PATIENTS WITH BREAST CANCER? A RANDOMIZED, CONTROLLED, SINGLE-BLIND TRIAL. OBJECTIVE: TO EXAMINE THE EFFECTS OF YOGA ON SHOULDER AND ARM PAIN, QUALITY OF LIFE (QOL), DEPRESSION, AND PHYSICAL PERFORMANCE IN PATIENTS WITH BREAST CANCER. METHODS: THIS PROSPECTIVE, RANDOMIZED STUDY INCLUDED 42 PATIENTS. THE PATIENTS IN GROUP 1 UNDERWENT A 10-WEEK HATHA YOGA EXERCISE PROGRAM. THE PATIENTS IN GROUP 2 WERE INCLUDED IN A 10-WEEK FOLLOW-UP PROGRAM. OUR PRIMARY ENDPOINT WAS ARM AND SHOULDER PAIN INTENSITY. RESULTS: THE GROUP RECEIVING YOGA SHOWED A SIGNIFICANT IMPROVEMENT IN THEIR PAIN SEVERITY FROM BASELINE TO POST-TREATMENT, AND THESE BENEFITS WERE MAINTAINED AT 2.5 MONTHS POST-TREATMENT. WHEN COMPARED TO THE CONTROL GROUP, THERE WERE NO STATISTICALLY SIGNIFICANT DIFFERENCES BETWEEN THE 2 GROUPS WITH RESPECT TO THE PARAMETERS ASSESSED AT THE END OF WEEK 10. CONCLUSION: YOGA WAS AN EFFECTIVE AND SAFE EXERCISE FOR ALLEVIATING SHOULDER AND ARM PAIN, WHICH IS A COMPLICATION WITH A HIGH PREVALENCE IN PATIENTS WITH BREAST CANCER.	2018	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
4 2605  34 YOGA FOR PERSISTENT FATIGUE IN BREAST CANCER SURVIVORS: RESULTS OF A PILOT STUDY. APPROXIMATELY ONE-THIRD OF BREAST CANCER SURVIVORS EXPERIENCES PERSISTENT FATIGUE FOR MONTHS OR YEARS AFTER SUCCESSFUL TREATMENT COMPLETION. THERE IS A LACK OF EVIDENCE-BASED TREATMENTS FOR CANCER-RELATED FATIGUE, PARTICULARLY AMONG CANCER SURVIVORS. THIS SINGLE-ARM PILOT STUDY EVALUATED THE FEASIBILITY AND PRELIMINARY EFFICACY OF A YOGA INTERVENTION FOR FATIGUED BREAST CANCER SURVIVORS BASED ON THE IYENGAR TRADITION. IYENGAR YOGA PRESCRIBES SPECIFIC POSES FOR INDIVIDUALS WITH SPECIFIC MEDICAL PROBLEMS AND CONDITIONS; THIS TRIAL EMPHASIZED POSTURES BELIEVED TO BE EFFECTIVE FOR REDUCING FATIGUE AMONG BREAST CANCER SURVIVORS, INCLUDING INVERSIONS AND BACKBENDS PERFORMED WITH THE SUPPORT OF PROPS. TWELVE WOMEN WERE ENROLLED IN THE TRIAL, AND 11 COMPLETED THE FULL 12-WEEK COURSE OF TREATMENT. THERE WAS A SIGNIFICANT IMPROVEMENT IN FATIGUE SCORES FROM PRE- TO POST-INTERVENTION THAT WAS MAINTAINED AT THE 3-MONTH POST-INTERVENTION FOLLOWUP. SIGNIFICANT IMPROVEMENTS WERE ALSO OBSERVED IN MEASURES OF PHYSICAL FUNCTION, DEPRESSED MOOD, AND QUALITY OF LIFE. THESE RESULTS SUPPORT THE ACCEPTABILITY OF THIS INTERVENTION AND SUGGEST THAT IT MAY HAVE BENEFICIAL EFFECTS ON PERSISTENT POST-TREATMENT FATIGUE. HOWEVER, RESULTS REQUIRE REPLICATION IN A LARGER RANDOMIZED CONTROLLED TRIAL.	2011	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
5 1650  56 MULTICENTER, RANDOMIZED CONTROLLED TRIAL OF YOGA FOR SLEEP QUALITY AMONG CANCER SURVIVORS. PURPOSE: THIRTY PERCENT TO 90% OF CANCER SURVIVORS REPORT IMPAIRED SLEEP QUALITY POST-TREATMENT, WHICH CAN BE SEVERE ENOUGH TO INCREASE MORBIDITY AND MORTALITY. LIFESTYLE INTERVENTIONS, SUCH AS EXERCISE, ARE RECOMMENDED IN CONJUNCTION WITH DRUGS AND COGNITIVE BEHAVIORAL THERAPY FOR THE TREATMENT OF IMPAIRED SLEEP. PRELIMINARY EVIDENCE INDICATES THAT YOGA-A MIND-BODY PRACTICE AND FORM OF EXERCISE-MAY IMPROVE SLEEP AMONG CANCER SURVIVORS. THE PRIMARY AIM OF THIS RANDOMIZED, CONTROLLED CLINICAL TRIAL WAS TO DETERMINE THE EFFICACY OF A STANDARDIZED YOGA INTERVENTION COMPARED WITH STANDARD CARE FOR IMPROVING GLOBAL SLEEP QUALITY (PRIMARY OUTCOME) AMONG POST-TREATMENT CANCER SURVIVORS. PATIENTS AND METHODS: IN ALL, 410 SURVIVORS SUFFERING FROM MODERATE OR GREATER SLEEP DISRUPTION BETWEEN 2 AND 24 MONTHS AFTER SURGERY, CHEMOTHERAPY, AND/OR RADIATION THERAPY WERE RANDOMLY ASSIGNED TO STANDARD CARE OR STANDARD CARE PLUS THE 4-WEEK YOGA INTERVENTION. THE YOGA INTERVENTION USED THE YOGA FOR CANCER SURVIVORS (YOCAS) PROGRAM CONSISTING OF PRANAYAMA (BREATHING EXERCISES), 16 GENTLE HATHA AND RESTORATIVE YOGA ASANAS (POSTURES), AND MEDITATION. PARTICIPANTS ATTENDED TWO 75-MINUTE SESSIONS PER WEEK. SLEEP QUALITY WAS ASSESSED BY USING THE PITTSBURGH SLEEP QUALITY INDEX AND ACTIGRAPHY PRE- AND POSTINTERVENTION. RESULTS: IN ALL, 410 SURVIVORS WERE ACCRUED (96% FEMALE; MEAN AGE, 54 YEARS; 75% HAD BREAST CANCER). YOGA PARTICIPANTS DEMONSTRATED GREATER IMPROVEMENTS IN GLOBAL SLEEP QUALITY AND, SECONDARILY, SUBJECTIVE SLEEP QUALITY, DAYTIME DYSFUNCTION, WAKE AFTER SLEEP ONSET, SLEEP EFFICIENCY, AND MEDICATION USE AT POSTINTERVENTION (ALL P </= .05) COMPARED WITH STANDARD CARE PARTICIPANTS. CONCLUSION: YOGA, SPECIFICALLY THE YOCAS PROGRAM, IS A USEFUL TREATMENT FOR IMPROVING SLEEP QUALITY AND REDUCING SLEEP MEDICATION USE AMONG CANCER SURVIVORS.	2013	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
6 2604  48 YOGA FOR PERSISTENT FATIGUE IN BREAST CANCER SURVIVORS: A RANDOMIZED CONTROLLED TRIAL. BACKGROUND: CANCER-RELATED FATIGUE AFFLICTS UP TO 33% OF BREAST CANCER SURVIVORS, YET THERE ARE NO EMPIRICALLY VALIDATED TREATMENTS FOR THIS SYMPTOM. METHODS: THE AUTHORS CONDUCTED A 2-GROUP RANDOMIZED CONTROLLED TRIAL TO DETERMINE THE FEASIBILITY AND EFFICACY OF AN IYENGAR YOGA INTERVENTION FOR BREAST CANCER SURVIVORS WITH PERSISTENT POST-TREATMENT FATIGUE. PARTICIPANTS WERE BREAST CANCER SURVIVORS WHO HAD COMPLETED CANCER TREATMENTS (OTHER THAN ENDOCRINE THERAPY) AT LEAST 6 MONTHS BEFORE ENROLLMENT, REPORTED SIGNIFICANT CANCER-RELATED FATIGUE, AND HAD NO OTHER MEDICAL CONDITIONS THAT WOULD ACCOUNT FOR FATIGUE SYMPTOMS OR INTERFERE WITH YOGA PRACTICE. BLOCK RANDOMIZATION WAS USED TO ASSIGN PARTICIPANTS TO A 12-WEEK, IYENGAR-BASED YOGA INTERVENTION OR TO 12 WEEKS OF HEALTH EDUCATION (CONTROL). THE PRIMARY OUTCOME WAS CHANGE IN FATIGUE MEASURED AT BASELINE, IMMEDIATELY POST-TREATMENT, AND 3 MONTHS AFTER TREATMENT COMPLETION. ADDITIONAL OUTCOMES INCLUDED CHANGES IN VIGOR, DEPRESSIVE SYMPTOMS, SLEEP, PERCEIVED STRESS, AND PHYSICAL PERFORMANCE. INTENT-TO-TREAT ANALYSES WERE CONDUCTED WITH ALL RANDOMIZED PARTICIPANTS USING LINEAR MIXED MODELS. RESULTS: THIRTY-ONE WOMEN WERE RANDOMLY ASSIGNED TO YOGA (N = 16) OR HEALTH EDUCATION (N = 15). FATIGUE SEVERITY DECLINED SIGNIFICANTLY FROM BASELINE TO POST-TREATMENT AND OVER A 3-MONTH FOLLOW-UP IN THE YOGA GROUP RELATIVE TO CONTROLS (P = .032). IN ADDITION, THE YOGA GROUP HAD SIGNIFICANT INCREASES IN VIGOR RELATIVE TO CONTROLS (P = .011). BOTH GROUPS HAD POSITIVE CHANGES IN DEPRESSIVE SYMPTOMS AND PERCEIVED STRESS (P < .05). NO SIGNIFICANT CHANGES IN SLEEP OR PHYSICAL PERFORMANCE WERE OBSERVED. CONCLUSIONS: A TARGETED YOGA INTERVENTION LED TO SIGNIFICANT IMPROVEMENTS IN FATIGUE AND VIGOR AMONG BREAST CANCER SURVIVORS WITH PERSISTENT FATIGUE SYMPTOMS.	2012	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
7 2442  40 YOGA AND SELF-REPORTED COGNITIVE PROBLEMS IN BREAST CANCER SURVIVORS: A RANDOMIZED CONTROLLED TRIAL. OBJECTIVES: CANCER SURVIVORS OFTEN REPORT COGNITIVE PROBLEMS. FURTHERMORE, DECREASES IN PHYSICAL ACTIVITY TYPICALLY OCCUR OVER THE COURSE OF CANCER TREATMENT. ALTHOUGH PHYSICAL ACTIVITY BENEFITS COGNITIVE FUNCTION IN NONCANCER POPULATIONS, EVIDENCE LINKING PHYSICAL ACTIVITY TO COGNITIVE FUNCTION IN CANCER SURVIVORS IS LIMITED. IN OUR RECENT RANDOMIZED CONTROLLED TRIAL, BREAST CANCER SURVIVORS WHO RECEIVED A YOGA INTERVENTION HAD LOWER FATIGUE AND INFLAMMATION FOLLOWING THE TRIAL COMPARED WITH A WAIT LIST CONTROL GROUP. THIS SECONDARY ANALYSIS OF THE PARENT TRIAL ADDRESSED YOGA'S IMPACT ON COGNITIVE COMPLAINTS. METHODS: POSTTREATMENT STAGE 0-IIIA BREAST CANCER SURVIVORS (N = 200) WERE RANDOMIZED TO A 12-WEEK, TWICE-WEEKLY HATHA YOGA INTERVENTION OR A WAIT LIST CONTROL GROUP. PARTICIPANTS REPORTED COGNITIVE COMPLAINTS USING THE BREAST CANCER PREVENTION TRIAL COGNITIVE PROBLEMS SCALE AT BASELINE, IMMEDIATELY POSTINTERVENTION, AND 3-MONTH FOLLOW-UP. RESULTS: COGNITIVE COMPLAINTS DID NOT DIFFER SIGNIFICANTLY BETWEEN GROUPS IMMEDIATELY POSTINTERVENTION (P = 0.250). HOWEVER, AT 3-MONTH FOLLOW-UP, YOGA PARTICIPANTS' BREAST CANCER PREVENTION TRIAL COGNITIVE PROBLEMS SCALE SCORES WERE AN AVERAGE OF 23% LOWER THAN WAIT LIST PARTICIPANTS' SCORES (P = 0.003). THESE GROUP DIFFERENCES IN COGNITIVE COMPLAINTS REMAINED AFTER CONTROLLING FOR PSYCHOLOGICAL DISTRESS, FATIGUE, AND SLEEP QUALITY. CONSISTENT WITH THE PRIMARY RESULTS, THOSE WHO PRACTICED YOGA MORE FREQUENTLY REPORTED SIGNIFICANTLY FEWER COGNITIVE PROBLEMS AT 3-MONTH FOLLOW-UP THAN THOSE WHO PRACTICED LESS FREQUENTLY (P < 0.001). CONCLUSIONS: THESE FINDINGS SUGGEST THAT YOGA CAN EFFECTIVELY REDUCE BREAST CANCER SURVIVORS' COGNITIVE COMPLAINTS AND PROMPT FURTHER RESEARCH ON MIND-BODY AND PHYSICAL ACTIVITY INTERVENTIONS FOR IMPROVING CANCER-RELATED COGNITIVE PROBLEMS.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
8 1865  40 RANDOMIZED PILOT TRIAL OF YOGA VERSUS STRENGTHENING EXERCISES IN BREAST CANCER SURVIVORS WITH CANCER-RELATED FATIGUE. PURPOSE: FATIGUE IS ONE OF THE MOST COMMON AND BOTHERSOME REFRACTORY SYMPTOMS EXPERIENCED BY CANCER SURVIVORS. MINDFUL EXERCISE INTERVENTIONS SUCH AS YOGA IMPROVE CANCER-RELATED FATIGUE; HOWEVER, STUDIES OF YOGA HAVE INCLUDED HETEROGENEOUS SURVIVORSHIP POPULATIONS, AND THE EFFECT OF YOGA ON FATIGUED SURVIVORS REMAINS UNCLEAR. METHODS: WE RANDOMLY ASSIGNED 34 EARLY-STAGE BREAST CANCER SURVIVORS WITH CANCER-RELATED FATIGUE (>/=4 ON A LIKERT SCALE FROM 1-10) WITHIN 1 YEAR FROM DIAGNOSIS TO A 12-WEEK INTERVENTION OF HOME-BASED YOGA VERSUS STRENGTHENING EXERCISES, BOTH PRESENTED ON A DVD. THE PRIMARY ENDPOINTS WERE FEASIBILITY AND CHANGES IN FATIGUE, AS MEASURED BY THE MULTIDIMENSIONAL FATIGUE SYMPTOM INVENTORY-SHORT FORM (MFSI-SF). SECONDARY ENDPOINT WAS QUALITY OF LIFE, ASSESSED BY THE FUNCTIONAL ASSESSMENT OF CANCER THERAPIES-BREAST (FACT-B). RESULTS: WE INVITED 401 WOMEN TO PARTICIPATE IN THE STUDY; 78 RESPONDED, AND WE ENROLLED 34. BOTH GROUPS HAD SIGNIFICANT WITHIN-GROUP IMPROVEMENT IN MULTIPLE DOMAINS OF THE FATIGUE AND QUALITY OF LIFE SCORES FROM BASELINE TO POST-INTERVENTION, AND THESE BENEFITS WERE MAINTAINED AT 3 MONTHS POST-INTERVENTION. HOWEVER, THERE WAS NO SIGNIFICANT DIFFERENCE BETWEEN GROUPS IN FATIGUE OR QUALITY OF LIFE AT ANY ASSESSMENT TIME. SIMILARLY, THERE WAS NO DIFFERENCE BETWEEN GROUPS IN ADHERENCE TO THE EXERCISE INTERVENTION. CONCLUSIONS: BOTH DVD-BASED YOGA AND STRENGTHENING EXERCISES DESIGNED FOR CANCER SURVIVORS MAY BE GOOD OPTIONS TO ADDRESS FATIGUE IN BREAST CANCER SURVIVORS. BOTH HAVE REASONABLE UPTAKE, ARE CONVENIENT AND REPRODUCIBLE, AND MAY BE HELPFUL IN DECREASING FATIGUE AND IMPROVING QUALITY OF LIFE IN THE FIRST YEAR POST-DIAGNOSIS IN BREAST CANCER PATIENTS WITH CANCER-RELATED FATIGUE.	2016	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
9 2508  39 YOGA BREATHING FOR CANCER CHEMOTHERAPY-ASSOCIATED SYMPTOMS AND QUALITY OF LIFE: RESULTS OF A PILOT RANDOMIZED CONTROLLED TRIAL. BACKGROUND: MANY DEBILITATING SYMPTOMS ARISE FROM CANCER AND ITS TREATMENT THAT ARE OFTEN UNRELIEVED BY ESTABLISHED METHODS. PRANAYAMA, A SERIES OF YOGIC BREATHING TECHNIQUES, MAY IMPROVE CANCER-RELATED SYMPTOMS AND QUALITY OF LIFE, BUT IT HAS NOT BEEN STUDIED FOR THIS PURPOSE. OBJECTIVES: A PILOT STUDY WAS PERFORMED TO EVALUATE FEASIBILITY AND TO TEST THE EFFECTS OF PRANAYAMA ON CANCER-ASSOCIATED SYMPTOMS AND QUALITY OF LIFE. DESIGN: THIS WAS A RANDOMIZED CONTROLLED CLINICAL TRIAL COMPARING PRANAYAMA TO USUAL CARE. SETTING: THE STUDY WAS CONDUCTED AT A UNIVERSITY MEDICAL CENTER. SUBJECTS: PATIENTS RECEIVING CANCER CHEMOTHERAPY WERE RANDOMIZED TO RECEIVE PRANAYAMA IMMEDIATELY OR AFTER A WAITING PERIOD (CONTROL GROUP). INTERVENTIONS: THE PRANAYAMA INTERVENTION CONSISTED OF FOUR BREATHING TECHNIQUES TAUGHT IN WEEKLY CLASSES AND PRACTICED AT HOME. THE TREATMENT GROUP RECEIVED PRANAYAMA DURING TWO CONSECUTIVE CYCLES OF CHEMOTHERAPY. THE CONTROL GROUP RECEIVED USUAL CARE DURING THEIR FIRST CYCLE, AND RECEIVED PRANAYAMA DURING THEIR SECOND CYCLE OF CHEMOTHERAPY. OUTCOME MEASURES: FEASIBILITY, CANCER-ASSOCIATED SYMPTOMS (FATIGUE, SLEEP DISTURBANCE, ANXIETY, DEPRESSION, STRESS), AND QUALITY OF LIFE WERE THE OUTCOMES. RESULTS: CLASS ATTENDANCE WAS NEARLY 100% IN BOTH GROUPS. SIXTEEN (16) PARTICIPANTS WERE INCLUDED IN THE FINAL INTENT-TO-TREAT ANALYSES. THE REPEATED-MEASURES ANALYSES DEMONSTRATED THAT ANY INCREASE IN PRANAYAMA DOSE, WITH DOSE MEASURED IN THE NUMBER OF HOURS PRACTICED IN CLASS OR AT HOME, RESULTED IN IMPROVED SYMPTOM AND QUALITY-OF-LIFE SCORES. SEVERAL OF THESE ASSOCIATIONS--SLEEP DISTURBANCE (P=0.04), ANXIETY (P=0.04), AND MENTAL QUALITY OF LIFE (P=0.05)--REACHED OR APPROACHED STATISTICAL SIGNIFICANCE. CONCLUSIONS: YOGA BREATHING WAS A FEASIBLE INTERVENTION AMONG PATIENTS WITH CANCER RECEIVING CHEMOTHERAPY. PRANAYAMA MAY IMPROVE SLEEP DISTURBANCE, ANXIETY, AND MENTAL QUALITY OF LIFE. A DOSE-RESPONSE RELATIONSHIP WAS FOUND BETWEEN PRANAYAMA USE AND IMPROVEMENTS IN CHEMOTHERAPY-ASSOCIATED SYMPTOMS AND QUALITY OF LIFE. THESE FINDINGS NEED TO BE CONFIRMED IN A LARGER STUDY.	2012	
                                                                                                                                                                                                                                                                                                                                                                                                                                   
10 2754  41 YOGA PRACTICE PREDICTS IMPROVEMENTS IN DAY-TO-DAY PAIN IN WOMEN WITH METASTATIC BREAST CANCER. CONTEXT: WOMEN WITH METASTATIC BREAST CANCER (MBC) EXPERIENCE A SIGNIFICANT SYMPTOM BURDEN, INCLUDING CANCER PAIN. YOGA IS A MIND-BODY DISCIPLINE THAT HAS SHOWN PROMISE FOR ALLEVIATING CANCER PAIN, BUT FEW STUDIES HAVE INCLUDED PATIENTS WITH METASTATIC DISEASE OR EXAMINED THE ACUTE EFFECTS OF YOGA PRACTICE. OBJECTIVES: TO DETERMINE WHETHER DAILY PAIN CHANGED SIGNIFICANTLY DURING A RANDOMIZED CONTROLLED TRIAL OF THE MINDFUL YOGA PROGRAM AMONG WOMEN WITH MBC AND WHETHER TIME SPENT IN YOGA PRACTICE WAS RELATED TO DAILY PAIN. METHODS: ON ALTERNATE WEEKS DURING THE INTERVENTION PERIOD, WE COLLECTED DAILY MEASURES OF PAIN FROM A SUBSET OF 48 WOMEN RANDOMIZED TO EITHER YOGA (N = 30) OR A SUPPORT GROUP CONDITION (N = 18). WE ALSO ASSESSED DAILY DURATION OF YOGA PRACTICE AMONG PATIENTS RANDOMIZED TO YOGA. RESULTS: PAIN LEVELS WERE LOW FOR WOMEN IN BOTH CONDITIONS, AND NO DIFFERENTIAL TREATMENT EFFECTS WERE FOUND ON DAILY PAIN. HOWEVER, AMONG WOMEN RANDOMIZED TO YOGA, A DOSE/RESPONSE RELATIONSHIP WAS FOUND BETWEEN YOGA PRACTICE DURATION AND DAILY PAIN. WHEN PATIENTS HAD SPENT RELATIVELY MORE TIME PRACTICING YOGA ACROSS TWO CONSECUTIVE DAYS, THEY WERE MORE LIKELY TO EXPERIENCE LOWER PAIN ON THE NEXT DAY. THIS FINDING IS CONSISTENT WITH AN EARLIER MBC STUDY. MEDITATION PRACTICE SHOWED THE STRONGEST ASSOCIATION WITH LOWER DAILY PAIN. CONCLUSION: FINDINGS SUGGEST THAT YOGA PRACTICE (MEDITATION PRACTICE IN PARTICULAR) IS ASSOCIATED WITH ACUTE IMPROVEMENTS IN CANCER PAIN, AND THAT YOGA INTERVENTIONS MAY BE MORE IMPACTFUL IF TESTED IN A SAMPLE OF PATIENTS WITH ADVANCED CANCER IN WHICH PAIN IS RELATIVELY ELEVATED.	2021	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
11 2096  43 THE EFFECT OF YOGA EXERCISE ON IMPROVING DEPRESSION, ANXIETY, AND FATIGUE IN WOMEN WITH BREAST CANCER: A RANDOMIZED CONTROLLED TRIAL. BACKGROUND: DEPRESSION, ANXIETY, AND FATIGUE ARE AMONG THE MOST SIGNIFICANT PROBLEMS THAT INFLUENCE THE QUALITY OF LIFE OF PATIENTS WITH BREAST CANCER WHO RECEIVE ADJUVANT CHEMOTHERAPY. ALTHOUGH EVIDENCE HAS SHOWN YOGA TO DECREASE ANXIETY, DEPRESSION, AND FATIGUE IN PATIENTS WITH CANCER, FEW STUDIES ON THE EFFECTS OF YOGA HAVE TARGETED PATIENTS WITH BREAST CANCER. YOGA INTERVENTIONS SHOULD BE TESTED TO PROMOTE THE PSYCHOLOGICAL AND PHYSICAL HEALTH OF WOMEN WITH BREAST CANCER. PURPOSE: THIS STUDY EXAMINES THE EFFECTIVENESS OF AN 8-WEEK YOGA EXERCISE PROGRAM IN PROMOTING THE PSYCHOLOGICAL AND PHYSICAL HEALTH OF WOMEN WITH BREAST CANCER UNDERGOING ADJUVANT CHEMOTHERAPY IN TERMS OF DEPRESSION, ANXIETY, AND FATIGUE. METHODS: A SAMPLE OF 60 WOMEN WITH NONMETASTATIC BREAST CANCER WAS RECRUITED. PARTICIPANTS WERE RANDOMLY ASSIGNED INTO EITHER THE EXPERIMENTAL GROUP (N = 30) OR THE CONTROL GROUP (N = 30). A 60-MINUTE, TWICE-PER-WEEK YOGA EXERCISE WAS IMPLEMENTED FOR 8 WEEKS AS THE INTERVENTION FOR THE PARTICIPANTS IN THE EXPERIMENTAL GROUP. THE CONTROL GROUP RECEIVED STANDARD CARE ONLY. RESULTS: ANALYSIS USING THE JOHNSON-NEYMAN PROCEDURE FOUND THAT THE YOGA EXERCISE REDUCED OVERALL FATIGUE AND THE INTERFERENCE OF FATIGUE IN EVERYDAY LIFE FOR THE EXPERIMENTAL GROUP PARTICIPANTS. SIGNIFICANT REDUCTIONS WERE OBTAINED AFTER 4 WEEKS OF INTERVENTION PARTICIPATION FOR THOSE EXPERIMENTAL GROUP PATIENTS WITH RELATIVELY LOW STARTING BASELINE VALUES (BASELINE ITEM MEAN VALUE < 3.31 AND 3.22, RESPECTIVELY) AND AFTER 8 WEEKS FOR MOST PATIENTS (APPROXIMATELY 75%) WITH MODERATE STARTING BASELINE VALUES (BASELINE ITEM MEAN VALUE < 7.30 AND 5.34, RESPECTIVELY). THE 8-WEEK INTERVENTION DID NOT SIGNIFICANTLY IMPROVE THE LEVELS OF DEPRESSION (F = 1.29, P > .05) OR ANXIETY (F = 2.7, P > .05). CONCLUSIONS/IMPLICATIONS FOR PRACTICE: THE 8-WEEK YOGA EXERCISE PROGRAM DEVELOPED IN THIS STUDY EFFECTIVELY REDUCED FATIGUE IN PATIENTS WITH BREAST CANCER BUT DID NOT REDUCE DEPRESSION OR ANXIETY. ONCOLOGY NURSES SHOULD STRENGTHEN THEIR CLINICAL HEALTH EDUCATION AND APPLY YOGA TO REDUCE THE FATIGUE EXPERIENCED BY PATIENTS WITH BREAST CANCER WHO UNDERGO ADJUVANT CHEMOTHERAPY.	2014	
                                                                                                                                                                                                                                                                                                                                                                 
12 1240  38 FEASIBILITY OF A MINDFUL YOGA PROGRAM FOR WOMEN WITH METASTATIC BREAST CANCER: RESULTS OF A RANDOMIZED PILOT STUDY. PURPOSE: PATIENTS WITH METASTATIC BREAST CANCER (MBC) EXPERIENCE HIGH LEVELS OF SYMPTOMS. YOGA INTERVENTIONS HAVE SHOWN PROMISE FOR IMPROVING CANCER SYMPTOMS BUT HAVE RARELY BEEN TESTED IN PATIENTS WITH ADVANCED DISEASE. THIS STUDY EXAMINED THE ACCEPTABILITY OF A COMPREHENSIVE YOGA PROGRAM FOR MBC AND THE FEASIBILITY OF CONDUCTING A RANDOMIZED TRIAL TESTING THE INTERVENTION. METHODS: SIXTY-THREE WOMEN WITH MBC WERE RANDOMIZED WITH A 2:1 ALLOCATION TO YOGA OR A SUPPORT GROUP COMPARISON CONDITION. BOTH INTERVENTIONS INVOLVED EIGHT WEEKLY GROUP SESSIONS. FEASIBILITY WAS QUANTIFIED USING RATES OF ACCRUAL, ATTRITION, AND SESSION ATTENDANCE. ACCEPTABILITY WAS ASSESSED WITH A STANDARDIZED SELF-REPORT MEASURE. PAIN, FATIGUE, SLEEP QUALITY, PSYCHOLOGICAL DISTRESS, MINDFULNESS, AND FUNCTIONAL CAPACITY WERE ASSESSED AT BASELINE, POST-INTERVENTION, AND 3 AND 6 MONTHS POST-INTERVENTION. RESULTS: WE MET GOALS FOR ACCRUAL AND RETENTION, WITH 50% OF ELIGIBLE PATIENTS ENROLLED AND 87% OF RANDOMIZED PARTICIPANTS COMPLETING POST-INTERVENTION SURVEYS. SIXTY-FIVE PERCENT OF WOMEN IN THE YOGA CONDITION AND 90% IN THE SUPPORT GROUP ATTENDED >/= 4 SESSIONS. EIGHTY PERCENT OF PARTICIPANTS IN THE YOGA CONDITION AND 65% IN THE SUPPORT GROUP INDICATED THAT THEY WERE HIGHLY SATISFIED WITH THE INTERVENTION. FOLLOWING TREATMENT, WOMEN IN THE YOGA INTERVENTION HAD MODEST IMPROVEMENTS IN SOME OUTCOMES; HOWEVER, OVERALL SYMPTOM LEVELS WERE LOW FOR WOMEN IN BOTH CONDITIONS. CONCLUSIONS: FINDINGS SUGGEST THAT THE YOGA INTERVENTION CONTENT WAS HIGHLY ACCEPTABLE TO PATIENTS WITH MBC, BUT THAT THERE ARE CHALLENGES TO IMPLEMENTING AN INTERVENTION INVOLVING EIGHT GROUP-BASED IN-PERSON SESSIONS. ALTERNATIVE MODES OF DELIVERY MAY BE NECESSARY TO REACH PATIENTS MOST IN NEED OF INTERVENTION.	2019	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
13 1233  41 FEASIBILITY AND PRELIMINARY EFFICACY OF TAILORED YOGA IN SURVIVORS OF HEAD AND NECK CANCER: A PILOT STUDY. PURPOSE: TREATMENT FOR HEAD AND NECK CANCER (HNC) RESULTS IN LONG-TERM TOXICITIES AND INCREASED PHYSICAL AND PSYCHOSOCIAL SURVIVOR BURDEN. THERE ARE A LIMITED NUMBER OF TREATMENTS FOR THESE LATE EFFECTS. YOGA POSTURES, BREATH WORK, RELAXATION, AND MEDITATION, MAY IMPROVE THESE LATE EFFECTS. THE PURPOSE OF THIS STUDY WAS TO EXAMINE THE FEASIBILITY OF A TAILORED YOGA PROGRAM IN HNC SURVIVORS AND OBTAIN PRELIMINARY EFFICACY DATA. METHODS: THIS WAS A RANDOMIZED WAIT-LIST CONTROL STUDY OF YOGA-NAIVE HNC SURVIVORS WHO WERE >3 MONTHS POST-CANCER TREATMENT. BASELINE DATA WERE COLLECTED. PARTICIPANTS WERE RANDOMIZED TO EITHER AN 8-WEEK HATHA YOGA INTERVENTION GROUP OR A WAIT-LIST GROUP. FEASIBILITY AND EFFICACY DATA WERE COLLECTED. AT 4 AND 8 WEEKS, PATIENTS UNDERWENT A REPEAT ASSESSMENT OF HEALTH. WAIT-LIST CONTROL GROUP PARTICIPANTS WERE OFFERED THE YOGA PROGRAM AFTER DATA COLLECTION. DESCRIPTIVE STATISTICS EVALUATED FEASIBILITY. MIXED EFFECTS GENERAL LINEAR MODELS WERE USED TO GENERATE ESTIMATES OF THE EFFICACY OUTCOMES. RESULTS: SEVENTY-THREE INDIVIDUALS WERE SCREENED AND 40 WERE ELIGIBLE. ALL ELIGIBLE INDIVIDUALS CONSENTED AND ENROLLED. FIVE OF THE INTERVENTION GROUP DISCONTINUED EARLY AND NONE IN THE WAIT-LIST CONTROL GROUP. FEASIBILITY WAS AFFIRMED AS PARTICIPANTS WERE RECRUITED AND RETAINED IN THE STUDY, THERE WERE NO ADVERSE EVENTS, FIDELITY TO PROTOCOL WAS DEMONSTRATED, AND SATISFACTION RATES WERE HIGH. EFFICACY MEASURES INDICATED POTENTIAL BENEFIT FOR SHOULDER RANGE OF MOTION ( D = 0.57-0.86, P < .05), PAIN ( D = 0.67-0.90, P </= .005), AND ANXIETY ( D = 0.59, P = .015). CONCLUSION: A TAILORED HATHA YOGA PROGRAM IS FEASIBLE AND POTENTIALLY EFFICACIOUS FOR HNC SURVIVORS. PRELIMINARY DATA SUPPORTS FURTHER INVESTIGATION OF YOGA IN THIS POPULATION IS NEEDED.	2018	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
14 1556  35 LONG-TERM CHANGES OF SYMPTOMS OF ANXIETY, DEPRESSION, AND FATIGUE IN CANCER PATIENTS 6 MONTHS AFTER THE END OF YOGA THERAPY. BACKGROUND: SYMPTOMS OF ANXIETY, DEPRESSION, AND CANCER-RELATED FATIGUE ARE COMMONLY ASSOCIATED WITH CANCER. CANCER PATIENTS INCREASINGLY USE COMPLEMENTARY AND ALTERNATIVE TREATMENTS, SUCH AS YOGA, TO COPE WITH PSYCHOLOGICAL AND PHYSICAL IMPAIRMENTS. IN THE PRESENT ARTICLE, LONG-TERM CHANGES OF ANXIETY, DEPRESSION, AND FATIGUE IN CANCER ARE EXAMINED 6 MONTHS AFTER A YOGA INTERVENTION. METHOD: WE USED AN OBSERVATIONAL DESIGN BASED ON A RANDOMIZED CONTROLLED STUDY IN CANCER PATIENTS WITH MIXED DIAGNOSES TO EVALUATE LONG-TERM CHANGES OF SYMPTOMS OF ANXIETY, DEPRESSION, AND FATIGUE 6 MONTHS AFTER THE END OF YOGA THERAPY. WE MEASURED ANXIETY SYMPTOMS WITH THE GENERALIZED ANXIETY DISORDER SCALE (GAD-7), DEPRESSIVE SYMPTOMS WITH THE PATIENT HEALTH QUESTIONNAIRE-2 (PHQ-2), AND FATIGUE WITH THE EUROPEAN ORGANIZATION FOR RESEARCH AND TREATMENT OF CANCER QUALITY OF LIFE QUESTIONNAIRE-FATIGUE SCALE (EORTC QLQ-FA13). YOGA THERAPY WAS PROVIDED IN YOGA CLASSES OF 60 MINUTES EACH ONCE A WEEK FOR 8 WEEKS IN TOTAL. THE EXERCISES PROVIDED CONTAINED BOTH BODY AND BREATHING ACTIVITIES AS WELL AS MEDITATION. RESULTS: A TOTAL OF 58 PATIENTS PARTICIPATED IN THE STUDY. SIX MONTHS AFTER THE END OF YOGA THERAPY, SYMPTOMS OF ANXIETY, DEPRESSION, AND FATIGUE WERE SIGNIFICANTLY REDUCED COMPARED WITH BASELINE. HOWEVER, SYMPTOMS OF ANXIETY AND FATIGUE SLIGHTLY INCREASED DURING THE FOLLOW-UP PERIOD, WHEREAS SYMPTOMS OF DEPRESSION REMAINED STABLE. CONCLUSION: OUR RESULTS ARE PROMISING AND SUPPORT THE INTEGRATION OF YOGA INTERVENTIONS IN SUPPORTIVE CANCER TREATMENT CONCEPTS BUT SHOULD BE CONFIRMED BY RANDOMIZED CONTROLLED TRIALS. LONG-TERM EFFECTS OF YOGA THERAPY ON CANCER PATIENTS SHOULD BE THE SUBJECT OF FURTHER RESEARCH.	2019	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
15 1564  40 LONGITUDINAL IMPACT OF YOGA ON CHEMOTHERAPY-RELATED COGNITIVE IMPAIRMENT AND QUALITY OF LIFE IN WOMEN WITH EARLY STAGE BREAST CANCER: A CASE SERIES. PURPOSE: ADJUVANT CHEMOTHERAPY FOR WOMEN WITH BREAST CANCER HAS SIGNIFICANTLY IMPROVED THE CURE RATE; HOWEVER, IT HAS BEEN ASSOCIATED WITH CHEMOTHERAPY-RELATED COGNITIVE IMPACT (CRCI). THE LITERATURE PROVIDES PRELIMINARY SUPPORT FOR THE FEASIBILITY AND EFFICACY OF YOGA INTERVENTIONS FOR THE GENERAL CANCER POPULATION, HOWEVER, CONTROLLED TRIALS ARE SCARCE AND NO STUDIES HAVE EXAMINED THE EFFECT OF YOGA ON COGNITION FOR WOMEN WITH BREAST CANCER DURING CHEMOTHERAPY. THIS CASE SERIES AIMS TO IDENTIFY THE IMPACT OF YOGA ON MEASURES OF COGNITION, FUNCTIONAL OUTCOMES, AND QUALITY OF LIFE (QOL) FOR BREAST CANCER SURVIVORS (BCS). METHODS: FOUR WOMEN WITH A DIAGNOSIS OF EARLY-STAGE BREAST CANCER PRIOR TO CHEMOTHERAPY TREATMENT WERE ADMINISTERED THE FOLLOWING PHYSIOLOGIC MEASURES AT BASELINE, 6, AND 12 WEEKS DURING CHEMOTHERAPY, AND AT ONE AND THREE MONTHS AFTER THE CONCLUSION OF THE STUDY: FUNCTIONAL REACH TEST (BALANCE) AND SIT AND REACH TEST (FLEXIBILITY), AND QOL, POMS (MOOD) AND FACT-B (QOL), AT BASELINE. PRIMARY OUTCOMES OF COGNITION WERE MEASURED WITH THE PERCEIVED COGNITION QUESTIONNAIRE (PCQ) AND COGSTATE, A COMPUTERIZED MEASUREMENT OF COGNITION. WOMEN ATTENDED AN IYENGAR-INSPIRED YOGA PROGRAM TWICE A WEEK FOR 12 WEEKS. QUALITATIVE QUESTIONNAIRES WERE ADMINISTERED AFTER THE COMPLETION OF THE STUDY TO DETERMINE PERCEIVED BENEFITS AND CHALLENGES OF THE YOGA PROGRAM. RESULTS: FOUR WOMEN WITH STAGE II BREAST CANCER RANGED IN AGE FROM 44-65 YEARS. COGSTATE COMPUTERIZED TESTING SHOWED CHANGES IN VARYING DOMAINS OF COGNITION THROUGH TREATMENT AND FOLLOW-UP. IMPROVED BALANCE, FLEXIBILITY, AND QOL WERE ALSO NOTED OVER TIME. NO ADVERSE EVENTS WERE OBSERVED. ANALYSIS OF QUALITATIVE DATA REVEALED THE YOGA CLASSES WERE HELPFUL AND SUBJECTS CONTINUED THE PRACTICE ELEMENTS OF YOGA INCLUDING RELAXATION, BREATHING, AND STRETCHING. THE MOST CHALLENGING ASPECT OF THE STUDY WAS PHYSICAL LIMITATIONS DUE TO VARIOUS MEDICAL COMPLICATIONS AND INCLUDED FATIGUE, DECREASED RANGE OF MOTION, AND PAIN. CONCLUSION: THIS CASE SERIES SUGGESTS THAT YOGA MAY IMPACT VARIOUS ASPECTS OF COGNITION DURING AND AFTER CHEMOTHERAPY ADMINISTRATION AS NOTED THROUGH QUANTITATIVE MEASURES. WOMEN DESCRIBE YOGA AS IMPROVING VARIOUS DOMAINS OF QOL THROUGH THE TREATMENT TRAJECTORY. THIS MIND-BODY INTERVENTION MAY STAVE OFF CRCI; HOWEVER, FURTHER INVESTIGATION IS NEEDED FOR ADDITIONAL RANDOMIZED CONTROLLED TRIALS ON THE EFFECTS OF YOGA ON COGNITION FOR WOMEN WITH BREAST CANCER UNDERGOING ADJUVANT CHEMOTHERAPY TREATMENT.	2012	

16 2156  31 THE EFFECTS OF THE BALI YOGA PROGRAM FOR BREAST CANCER PATIENTS ON CHEMOTHERAPY-INDUCED NAUSEA AND VOMITING: RESULTS OF A PARTIALLY RANDOMIZED AND BLINDED CONTROLLED TRIAL. COMPLEMENTARY AND ALTERNATIVE MEDICINE HAS BEEN SHOWN TO BE BENEFICIAL IN REDUCING CHEMOTHERAPY-INDUCED NAUSEA AND VOMITING. HOWEVER, CONCLUSIVE RESULTS ARE LACKING IN ORDER TO CONFIRM ITS USEFULNESS. THE PURPOSE OF THIS STUDY WAS TO DETERMINE WHETHER A STANDARDIZED YOGA INTERVENTION COULD REDUCE THESE ADVERSE SYMPTOMS. THIS WAS A PARTIALLY RANDOMIZED AND BLINDED CONTROLLED TRIAL COMPARING A STANDARDIZED YOGA INTERVENTION WITH STANDARD CARE. ELIGIBLE PATIENTS WERE ADULTS DIAGNOSED WITH STAGES I TO III BREAST CANCER RECEIVING CHEMOTHERAPY. PATIENTS RANDOMIZED TO THE EXPERIMENTAL GROUP PARTICIPATED IN AN 8-WEEK YOGA PROGRAM. THERE WAS NO SIGNIFICANT DIFFERENCE BETWEEN THE EXPERIMENTAL AND CONTROL GROUPS ON CHEMOTHERAPY-INDUCED NAUSEA AND VOMITING AFTER 8 WEEKS. RESULTS SUGGEST THE YOGA PROGRAM IS NOT BENEFICIAL IN MANAGING THESE ADVERSE SYMPTOMS. HOWEVER, CONSIDERING PRELIMINARY EVIDENCE SUGGESTING YOGA'S BENEFICIAL IMPACT IN CANCER SYMPTOM MANAGEMENT, METHODOLOGICAL LIMITATIONS SHOULD BE EXPLORED AND ADDITIONAL STUDIES SHOULD BE CONDUCTED.	2017	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
17   71  33 A FEASIBILITY STUDY OF RESTORATIVE YOGA VERSUS VIGOROUS YOGA INTERVENTION FOR SEDENTARY BREAST AND OVARIAN CANCER SURVIVORS. YOGA HAS BEEN SHOWN TO IMPROVE CANCER SURVIVORS' QUALITY OF LIFE, YET REGULAR YOGA PRACTICE IS A CHALLENGE FOR THOSE WHO ARE SEDENTARY. WE CONDUCTED A PILOT RANDOMIZED CONTROLLED STUDY TO ASSESS FEASIBILITY AND ADHERENCE OF TWO TYPES OF YOGA INTERVENTION AMONG SEDENTARY CANCER SURVIVORS. SEDENTARY BREAST AND OVARIAN CANCER SURVIVORS WERE RANDOMIZED TO PRACTICE EITHER RESTORATIVE YOGA (MINIMAL PHYSICAL EXERTION, GROUP R) OR VIGOROUS YOGA (CONSIDERABLE PHYSICAL EXERTION, GROUP V) IN THREE 60-MINUTE SUPERVISED SESSIONS A WEEK FOR 12 WEEKS, FOLLOWED BY 12 WEEKS OF HOME PRACTICE. ACCRUAL, ADHERENCE, AND ATTENDANCE RATES WERE ASSESSED. OF THE 226 ELIGIBLE PATIENTS, 175 (77%) DECLINED TO PARTICIPATE IN THE STUDY, CITING TIME COMMITMENT AND TRAVEL AS THE MOST COMMON BARRIERS. FORTY-TWO SUBJECTS CONSENTED TO PARTICIPATE IN THE STUDY. OF THE 35 PARTICIPANTS WHO BEGAN THE INTERVENTION (20 IN GROUP R AND 15 IN GROUP V), ADHERENCE RATE (PERCENTAGE REMAINING IN THE STUDY AT WEEK 12) WAS 100% AND 87%, RESPECTIVELY. RATE OF ADEQUATE ATTENDANCE (MORE THAN 66% OF THE SCHEDULED SUPERVISED SESSIONS) WAS 85% AND 73%, RESPECTIVELY. RATE OF COMPLETION OF THE HOME PRACTICE PERIOD WAS 85% AND 77%, RESPECTIVELY. IN THIS STUDY, SEDENTARY CANCER SURVIVORS WERE ABLE TO ADHERE TO A LONG-TERM, REGULAR YOGA REGIMEN. THE RATE OF ADEQUATE ATTENDANCE WAS HIGHER FOR RESTORATIVE YOGA. FUTURE STUDIES FOR SEDENTARY PATIENTS SHOULD FOCUS ON REDUCING TIME COMMITMENT AND TRAVEL REQUIREMENTS TO IMPROVE RECRUITMENT, AND ON USING RESTORATIVE YOGA AS A MORE FEASIBLE INTERVENTION FOR THIS POPULATION.	2018	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
18 2553  29 YOGA FOR CHILDREN AND ADOLESCENTS AFTER COMPLETING CANCER TREATMENT. SURVIVORS OF CHILDHOOD CANCER MAY EXPERIENCE PERSISTENT SYMPTOMS, INCLUDING FATIGUE, SLEEP DISTURBANCE, AND BALANCE IMPAIRMENT. YOGA IS A COMPLEMENTARY THERAPY THAT IMPROVES FATIGUE, SLEEP, AND QUALITY OF LIFE IN ADULT CANCER SURVIVORS. USING A ONE GROUP, REPEATED MEASURES DESIGN, WE EVALUATED THE FEASIBILITY OF A YOGA PROGRAM AND ASSESSED IF CANCER SURVIVOR PARTICIPANTS AGES 10 TO 17 YEARS (N = 13) HAD SIGNIFICANTLY LESS FATIGUE AND ANXIETY, AND BETTER BALANCE AND SLEEP, AFTER A 6-WEEK YOGA INTERVENTION COMPARED WITH A 6-WEEK PRE-INTERVENTION WAIT PERIOD. STUDY RECRUITMENT WAS CHALLENGING WITH A 32% ENROLLMENT RATE; YOGA ATTENDANCE WAS 90%. NONE OF THE SCORES FOR ANXIETY, FATIGUE, SLEEP, AND BALANCE HAD SIGNIFICANT CHANGES DURING THE WAIT PERIOD. AFTER THE 6-WEEK YOGA PROGRAM, CHILDREN (N = 7) HAD A SIGNIFICANT DECREASE IN ANXIETY SCORE (P = .04) WHILE ADOLESCENT SCORES (N = 7) SHOWED A DECREASING TREND (P = .10). SCORES FOR FATIGUE, SLEEP, AND BALANCE REMAINED STABLE POST-INTERVENTION. FATIGUE AND BALANCE SCORES WERE BELOW NORMS FOR HEALTH CHILDREN/ADOLESCENTS WHILE SLEEP AND ANXIETY SCORES WERE SIMILAR TO HEALTHY PEERS.	2016	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
19 1859  41 RANDOMIZED CONTROLLED PILOT TRIAL OF YOGA IN OVERWEIGHT AND OBESE BREAST CANCER SURVIVORS: EFFECTS ON QUALITY OF LIFE AND ANTHROPOMETRIC MEASURES. PURPOSE: TO OBTAIN ESTIMATES OF TIME TO RECRUIT THE STUDY SAMPLE, RETENTION, FACILITY-BASED CLASS ATTENDANCE AND HOME PRACTICE FOR A STUDY OF YOGA IN BREAST CANCER SURVIVORS, AND ITS EFFICACY ON FATIGUE, QUALITY OF LIFE (QOL), AND WEIGHT CHANGE. METHODS: SIXTY-THREE POST-TREATMENT STAGES 0-III BORDERLINE OVERWEIGHT AND OBESE (BODY MASS INDEX >/= 24 KG/M(2)) BREAST CANCER SURVIVORS WERE RANDOMLY ASSIGNED TO A 6-MONTH, FACILITY- AND HOME-BASED VINIYOGA INTERVENTION (N = 32) OR A WAITLIST CONTROL GROUP (N = 31). THE YOGA GOAL WAS FIVE PRACTICES PER WEEK. PRIMARY OUTCOME MEASURES WERE CHANGES IN QOL, FATIGUE, AND WEIGHT FROM BASELINE TO 6 MONTHS. SECONDARY OUTCOMES INCLUDED CHANGES IN WAIST AND HIP CIRCUMFERENCE. RESULTS: IT TOOK 12 MONTHS TO COMPLETE RECRUITMENT. PARTICIPANTS ATTENDED A MEAN OF 19.6 CLASSES AND PRACTICED AT HOME A MEAN OF 55.8 TIMES DURING THE 6-MONTH PERIOD. AT FOLLOW-UP, 90% OF PARTICIPANTS COMPLETED QUESTIONNAIRES AND 87% COMPLETED ANTHROPOMETRIC MEASUREMENTS. QOL AND FATIGUE IMPROVED TO A GREATER EXTENT AMONG WOMEN IN THE YOGA GROUP RELATIVE TO WOMEN IN THE CONTROL GROUP, ALTHOUGH NO DIFFERENCES WERE STATISTICALLY SIGNIFICANT. WAIST CIRCUMFERENCE DECREASED 3.1 CM (95% CI, -5.7 AND -0.4) MORE AMONG WOMEN IN THE YOGA COMPARED WITH THE CONTROL GROUP, WITH NO DIFFERENCE IN WEIGHT CHANGE. CONCLUSIONS: THIS STUDY PROVIDES IMPORTANT INFORMATION REGARDING RECRUITMENT, RETENTION, AND PRACTICE LEVELS ACHIEVED DURING A 6-MONTH, INTENSIVE YOGA INTERVENTION IN OVERWEIGHT AND OBESE BREAST CANCER SURVIVORS. YOGA MAY HELP DECREASE WAIST CIRCUMFERENCE AND IMPROVE QUALITY OF LIFE; FUTURE STUDIES ARE NEEDED TO CONFIRM THESE RESULTS.	2012	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
20 1901  37 RESTORATIVE YOGA FOR WOMEN WITH OVARIAN OR BREAST CANCER: FINDINGS FROM A PILOT STUDY. YOGA HAS DEMONSTRATED BENEFIT IN HEALTHY INDIVIDUALS AND THOSE WITH VARIOUS HEALTH CONDITIONS. THERE ARE, HOWEVER, FEW SYSTEMATIC STUDIES TO SUPPORT THE DEVELOPMENT OF YOGA INTERVENTIONS FOR CANCER PATIENTS. RESTORATIVE YOGA (RY) IS A GENTLE TYPE OF YOGA THAT HAS BEEN DESCRIBED AS "ACTIVE RELAXATION." THE SPECIFIC AIMS OF THIS PILOT STUDY WERE TO DETERMINE THE FEASIBILITY OF IMPLEMENTING AN RY INTERVENTION AS A SUPPORTIVE THERAPY FOR WOMEN DIAGNOSED WITH OVARIAN OR BREAST CANCER AND TO MEASURE CHANGES IN SELF-REPORTED FATIGUE, PSYCHOLOGICAL DISTRESS AND WELL-BEING, AND QUALITY OF LIFE. FIFTY-ONE WOMEN WITH OVARIAN (N = 37) OR BREAST CANCER (N = 14) WITH A MEAN AGE OF 58.9 YEARS ENROLLED IN THIS STUDY; THE MAJORITY (61%) WERE ACTIVELY UNDERGOING CANCER TREATMENT AT THE TIME OF ENROLLMENT. ALL STUDY PARTICIPANTS PARTICIPATED IN 10 WEEKLY 75-MINUTE RY CLASSES THAT COMBINED PHYSICAL POSTURES, BREATHING, AND DEEP RELAXATION. STUDY PARTICIPANTS COMPLETED QUESTIONNAIRES AT BASELINE, IMMEDIATELY POSTINTERVENTION, AND 2 MONTHS POSTINTERVENTION. SIGNIFICANT IMPROVEMENTS WERE SEEN FOR DEPRESSION, NEGATIVE AFFECT, STATE ANXIETY, MENTAL HEALTH, AND OVERALL QUALITY OF LIFE. FATIGUE DECREASED BETWEEN BASELINE AND POSTINTERVENTION FOLLOW-UP. HEALTH-RELATED QUALITY OF LIFE IMPROVED BETWEEN BASELINE AND THE 2-MONTH FOLLOW-UP. QUALITATIVE FEEDBACK FROM PARTICIPANTS WAS PREDOMINANTLY POSITIVE; RELAXATION AND SHARED GROUP EXPERIENCE WERE TWO COMMON THEMES.	2008