1 1917 161 ROLE OF YOGA AND ITS PLAUSIBLE MECHANISM IN THE MITIGATION OF DNA DAMAGE IN TYPE-2 DIABETES: A RANDOMIZED CLINICAL TRIAL. BACKGROUND: ALTHOUGH YOGA IS FOUND TO BE BENEFICIAL IN THE MANAGEMENT OF TYPE 2 DIABETES (T2D), ITS MECHANISM OF ACTION IS POORLY UNDERSTOOD. T2D IS ALSO KNOWN TO BE ASSOCIATED WITH INCREASED OXIDATIVE STRESS (OS) AND DNA DAMAGE. PURPOSE: THIS STUDY EXAMINES HOW YOGA MODULATES OS-INDUCED DNA DAMAGE AND THE EFFICIENCY OF DNA REPAIR IN T2D CONDITIONS. METHODS: IN THIS ASSESSOR-MASKED RANDOMIZED CLINICAL TRIAL, T2D SUBJECTS (N = 61), AGED (MEAN +/- SD, 50.3 +/- 4.2) WERE RANDOMLY ALLOCATED INTO YOGA GROUP (31) THAT RECEIVED 10 WEEKS OF YOGA INTERVENTION AND CONTROL (30) WITH ROUTINE EXERCISES. MOLECULAR AND BIOCHEMICAL ASSESSMENTS WERE DONE BEFORE AND AFTER THE INTERVENTION PERIOD. STRUCTURAL EQUATION MODELING USING "R" WAS USED FOR MEDIATION ANALYSIS. RESULTS: AT THE END OF THE 10TH WEEK, YOGA GROUP SHOWED SIGNIFICANT REDUCTION IN DNA DAMAGE INDICATORS LIKE TAIL MOMENT (-5.88[95%CI: -10.47 TO -1.30]; P = .013) AND OLIVE TAIL MOMENT (-2.93[95%CI: -4.87 TO -1.00]; P < .01), OXIDATIVE DNA DAMAGE MARKER 8-OHDG (-60.39[95%CI: -92.55 TO -28.23]; P < .001) AND FASTING BLOOD SUGAR (-22.58[95%CI: -44.33 TO -0.83]; P = .042) COMPARED TO CONTROL. OGG1 PROTEIN EXPRESSION INDICATING DNA REPAIR, IMPROVED SIGNIFICANTLY (17.55[95%CI:1.37 TO 33.73]; P = .034) WHEREAS TOTAL ANTIOXIDANT CAPACITY DID NOT (5.80[95%CI: -0.86 TO 12.47]; P = 0.086). MEDIATION ANALYSIS INDICATED THAT IMPROVEMENTS IN OXIDATIVE DNA DAMAGE AND DNA REPAIR TOGETHER PLAYED A MAJOR MEDIATORY ROLE (97.4%) IN CARRYING THE EFFECT OF YOGA. CONCLUSION: THE BENEFICIAL EFFECT OF YOGA ON DNA DAMAGE IN T2D SUBJECTS WAS FOUND TO BE MEDIATED BY MITIGATION OF OXIDATIVE DNA DAMAGE AND ENHANCEMENT OF DNA REPAIR. CLINICAL TRIAL INFORMATION: (WWW.CTRI.NIC.IN) CTRI/2018/07/014825. 2022 2 2747 35 YOGA PRACTICE IN DIABETES IMPROVES PHYSICAL AND PSYCHOLOGICAL OUTCOMES. BACKGROUND: THE AIM OF THIS STUDY WAS TO EXAMINE THE EFFECT OF YOGA PRACTICE ON CLINICAL AND PSYCHOLOGICAL OUTCOMES IN SUBJECTS WITH TYPE 2 DIABETES MELLITUS (T2DM). METHODS: IN A 40-DAY YOGA CAMP AT THE INSTITUTE OF YOGA AND CONSCIOUSNESS, AMBULATORY SUBJECTS WITH T2DM NOT HAVING SIGNIFICANT COMPLICATIONS (N = 35) PARTICIPATED IN A 40-DAY YOGA CAMP, WHERE YOGIC PRACTICES WERE OVERSEEN BY TRAINED YOGA TEACHERS. CLINICAL, BIOCHEMICAL, AND PSYCHOLOGICAL WELL-BEING WERE STUDIED AT BASELINE AND AT THE END OF THE CAMP. RESULTS: AT THE END OF THE STUDY, THERE WAS A REDUCTION OF BODY MASS INDEX (BMI) (26.514 +/- 3.355 TO 25.771 +/- 3.40; P < 0.001) AND ANXIETY (6.20 +/- 3.72 TO 4.29 +/- 4.46; P < 0.05) AND AN IMPROVEMENT IN TOTAL GENERAL WELL-BEING (48.6 +/- 11.13 TO 52.66 +/- 52.66 +/- 12.87; P < 0.05). CONCLUSIONS: PARTICIPATION OF SUBJECTS WITH T2DM IN YOGA PRACTICE FOR 40 DAYS RESULTED IN REDUCED BMI, IMPROVED WELL-BEING, AND REDUCED ANXIETY. 2009 3 2905 35 [LONG-TERM EFFECTS OF BREATHING EXERCISES AND YOGA IN PATIENTS WITH BRONCHIAL ASTHMA]. TO COMPARE THE EFFECTS OF BREATHING EXERCISES (BE) OR YOGA (Y) ON THE COURSE OF BRONCHIAL ASTHMA WE STUDIED 36 SUBJECTS WITH A MILD DISEASE. THE PATIENTS WERE RANDOMLY DIVIDED INTO 3 GROUPS. 2 OF THEM PARTICIPATED IN A 3 WEEKS TRAINING PROGRAM OF BE OR Y WHILE THE THIRD GROUP RESTED WITHOUT ANY ADDITIONAL TREATMENT (CONTROL GROUP, C). AT THE END OF THE TRAINING PERIOD THE PATIENTS WERE ASKED TO PRACTISE BE OR Y ON THEIR OWN. DRUG THERAPY AND LUNG FUNCTION PARAMETERS BEFORE AND AFTER A BETA 2-AGONIST METERED DOSE INHALER (ALBUTEROL, ALB) WERE RECORDED PRIOR TO THE TRAINING PROGRAM AND IN 4 WEEKS INTERVALS FOR 4 MONTHS THEREAFTER. THE RESPONSE TO THE BETA 2-AGONIST WAS DOCUMENTED CONTINUOUSLY IN 28 PATIENTS. THE MENTAL STATE OF THE PATIENTS WAS ELUCIDATED BY QUESTIONNAIRES.--PRIOR TO THE STUDY A SIGNIFICANT EFFECT OF INHALED ALB ON THE FEV1 WAS SHOWN WITHOUT ANY SIGNIFICANT BETWEEN GROUP DIFFERENCES. BOTH, BE AND Y, CAUSED A SIGNIFICANT AMELIORATION OF THE MENTAL STATE BUT ONLY THE BE INDUCED A SIGNIFICANT IMPROVEMENT OF LUNG FUNCTION PARAMETERS COMPARED TO THE INDIVIDUAL BASELINE VALUES. THE FEV1 INCREASED SIGNIFICANTLY BY 356.3 +/- 146.2 ML (P < 0.05) AND THE VC BY 225.0 +/- 65.5 ML (P < 0.01). THESE LONG-TERM CHANGES WERE NOT SIGNIFICANTLY DIFFERENT FROM THE ACTUAL RESPONSE TO ALB. BE DECREASED THE RV SIGNIFICANTLY BY 306.3 +/- 111.6 ML (P < 0.05), AN EFFECT SIGNIFICANTLY HIGHER COMPARED TO THE BETA 2-AGONIST (P < 0.01). BE IN COMBINATION WITH ALB CAUSED AN ADDITIVE EFFECT.(ABSTRACT TRUNCATED AT 250 WORDS) 1994 4 1932 37 ROLE OF YOGA IN MODIFYING ANXIETY LEVEL IN WOMEN. ANXIETY LEADS TO DERANGEMENT IN PHYSICAL AND MENTAL HEALTH. ANXIETY LEVELS ARE MORE IN FULL TIME HOUSEWIVES THAN WORKING WOMEN. THERE IS A NEED FOR SIMPLE, EASY TREATMENT FOR ANXIETY TO ALLEVIATE THE BURDEN ON HEALTH CAUSED BY ANXIETY. YOGA IS AMONG THE TOP TEN COMPLEMENTARY AND ALTERNATIVE MEDICINE THERAPIES. OUR STUDY AIMED TO DETERMINE THE ANXIETY LEVELS IN APPARENTLY HEALTHY FULL TIME HOUSEWIVES AND TO STUDY THE EFFECTS OF YOGA ON ANXIETY LEVELS AMONG THEM. PRESENT STUDY IS A COMPARATIVE INTERVENTIONAL STUDY. STUDY WAS CONDUCTED ON 50 APPARENTLY HEALTHY FULL TIME HOUSEWIVES (20-50 YEARS) WHO ATTENDED ONE MONTH YOGA CAMP. HAMILTON ANXIETY (HAMA) SCALE WAS USED TO EVALUATE ANXIETY LEVELS BEFORE AND AT THE END OF THE YOGA CAMP. STATISTICAL ANALYSIS WAS DONE BY PAIRED T TEST USING SPSS 9.0. THE BASELINE PULSE RATE, SBP, DBP WERE 82.90 +/- 4.25 BPM, 124.84 +/- 11.022 MM HG, 85.20 +/- 10.81 MM HG RESPECTIVELY. AFTER FOUR WEEKS YOGA CAMP THERE WAS STATISTICALLY SIGNIFICANT LOWERING OF PULSE RATE (77.58 +/- 3.86 BPM), SBP (117.92 +/- 6.76 MM HG), DBP (78.68 +/- 6.62 MM HG). BEFORE YOGA TRAINING, PERCENTAGE DISTRIBUTIONS OF SUBJECTS WITH MILD, MODERATE AND SEVERE ANXIETY WERE 6%, 18% AND 76% RESPECTIVELY. AT THE END OF FOUR WEEK YOGA TRAINING, PERCENTAGE DISTRIBUTIONS OF SUBJECTS WITH MILD, MODERATE AND SEVERE ANXIETY WERE 44.23%, 19.23% AND 36.53% RESPECTIVELY. THERE WAS HIGHLY SIGNIFICANT (P = 0.000) DIFFERENCE IN THE MEAN VALUES OF TOTAL SCORE BEFORE (33.71 +/- 4.90) AND AFTER (26.93 +/- 4.53) YOGA. THESE RESULTS INDICATE THAT THERE WAS A REDUCTION IN THE SEVERITY OF ANXIETY FROM SEVERE TO MODERATE AND MILD INDICATING DECREASE IN ANXIETY FOLLOWING YOGA. BASED ON THE RESULTS OF OUR STUDY, WE CONCLUDE THAT REGULAR YOGIC PRACTICES AND ADAPTING AND IMPLEMENTING THE PRINCIPALS AND PHILOSOPHY OF YOGA IN DAY TO DAY LIFE MAY DECREASE THE ANXIETY LEVEL. 2014 5 712 35 EFFECT OF INTEGRATED YOGA ON ANTI-PSYCHOTIC INDUCED SIDE EFFECTS AND COGNITIVE FUNCTIONS IN PATIENTS SUFFERING FROM SCHIZOPHRENIA. BACKGROUND TWENTY ONE (12 FEMALES) SUBJECTS, DIAGNOSED WITH SCHIZOPHRENIA BY A PSYCHIATRIST USING ICD-10, IN THE AGES 52.87 + 9.5YEARS AND SUFFERING SINCE 24.0 +/- 3.05YEARS WERE RECRUITED INTO THE STUDY FROM A SCHIZOPHRENIA REHABILITATION CENTER IN BENGALURU. METHODS ALL SUBJECTS WERE TAKING ANTI-PSYCHOTIC MEDICATIONS AND WERE IN STABLE STATE FOR MORE THAN A MONTH. PSYCHIATRIC MEDICATIONS WERE KEPT CONSTANT DURING THE STUDY PERIOD. ASSESSMENTS WERE DONE AT THREE POINTS OF TIME: (1) BASELINE, (2) AFTER ONE MONTH OF USUAL ROUTINE (PRE) AND (3) AFTER FIVE MONTHS OF VALIDATED INTEGRATED YOGA (IY) INTERVENTION (POST). VALIDATED 1H YOGA MODULE (CONSISTING OF ASANAS, PRANAYAMA, RELAXATION TECHNIQUES AND CHANTINGS) WAS PRACTICED FOR 5MONTHS, FIVE SESSIONS PER WEEK. ANTIPSYCHOTIC-INDUCED SIDE EFFECTS WERE ASSESSED USING SIMPSON ANGUS SCALE (SAS) AND UDVALG FOR KLINISKE UNDERSOGELSER (UKU) SIDE EFFECT RATING SCALE. COGNITIVE FUNCTIONS (USING TRAIL MAKING TEST A AND B), CLINICAL SYMPTOMS AND ANTHROPOMETRY WERE ASSESSED AS SECONDARY VARIABLES. COMPARISONS BETWEEN "PRE" AND "POST" DATA WAS DONE USING PAIRED SAMPLES T-TESTS AFTER SUBTRACTING BASELINE SCORES FROM THEM RESPECTIVELY. RESULTS AT THE END OF FIVE MONTHS, SIGNIFICANT REDUCTION IN DRUG-INDUCED PARKINSONIAN SYMPTOMS (SAS SCORE; P=0.001) AND 38 ITEMS OF UKU SCALE WAS OBSERVED ALONG WITH SIGNIFICANT IMPROVEMENT IN PROCESSING SPEED, EXECUTIVE FUNCTIONS AND NEGATIVE SYMPTOMS OF SCHIZOPHRENIA PATIENTS. NO SIDE EFFECTS OF YOGA WERE REPORTED. CONCLUSIONS THE PRESENT STUDY PROVIDES PRELIMINARY EVIDENCE FOR USEFULNESS OF INTEGRATED YOGA INTERVENTION IN MANAGING ANTI-PSYCHOTIC-INDUCED SIDE EFFECTS. 2018 6 359 36 ASSOCIATION OF LEUKOCYTE TELOMERE LENGTH WITH OXIDATIVE STRESS IN YOGA PRACTITIONERS. OBJECTIVE: YOGA IS A MIND-BODY MODULATION TECHNIQUE THAT HAS BEEN SHOWN TO HAVE BENEFICIAL EFFECTS ON VARIOUS DISEASES RELATED TO VARIOUS SYSTEMS IN THE BODY. HOWEVER, THE MOLECULAR BASIS OF MECHANISM OF ACTION IS NOT CLEAR. HENCE, THIS STUDY WAS DESIGNED TO STUDY THE LEUKOCYTE TELOMERE BIOLOGY AND ITS RELATION WITH HOMOCYSTEINE AND OXIDATIVE STRESS IN YOGA PRACTITIONERS. MATERIALS AND METHODS: THIS IS A PROSPECTIVE CASE-CONTROL STUDY INVOLVING YOGA PRACTITIONERS AGED 30-40 Y WITH MINIMUM OF TWO YEARS YOGA PRACTICE (YOGA GROUP) AND AGE, GENDER AND BODY MASS INDEX MATCHED SEDENTARY HEALTHY GENERAL POPULATION WITH NO MEDICAL PROBLEMS (CONTROL GROUP). LEUKOCYTE TELOMERE LENGTH (LTL) WAS MEASURED BY USING QUANTITATIVE PCR (QPCR), FASTING PLASMA HOMOCYSTEINE WAS MEASURED BY A RAPID HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY ASSAY AND THE OXIDATIVE STRESS WAS ASSESSED WITH TOTAL ANTIOXIDANT STATUS (TAOS), MALONDIALDEHYDE (MDA) MEASURED BY CALORIMETRY. RESULTS: THE LTL WAS SHORTER IN CONTROL GROUP THAN IN YOGA GROUP (P<0.001). THE TAOS WAS MORE IN YOGA GROUP WHEN COMPARED TO CONTROL GROUP (P=0.008), MDA AND HOMOCYSTEINE WAS HIGH IN CONTROL GROUP WHEN COMPARED TO YOGA GROUP (P<0.001). FURTHER, THE LTL WAS POSITIVELY CORRELATED WITH TAOS (R=0.841, P<0.001) AND NEGATIVELY CORRELATED WITH MDA (R=-0.931, P<0.001) AND HOMOCYSTEINE (R=-0.756, P<0.001). CONCLUSION: THE LTL IS WELL-PRESERVED IN PEOPLE WHO PRACTICE YOGA REGULARLY WITH LOWER SYSTEMIC OXIDATIVE STRESS COMPARED TO THOSE WHO HAVE A RELATIVELY SEDENTARY LIFESTYLE DESPITE LACK OF ANY MEDICAL DISORDERS. THE HABITUAL YOGA PRACTICE SEEMS TO INHIBIT REPLICATIVE CELLULAR SENESCENCE. 2015 7 918 25 EFFECTIVENESS OF TRAINING PROGRAM COMBINING CHAKRAYOGA AND MEDITATION. BACKGROUND THIS STUDY WAS DESIGNED TO EXAMINE THE EFFECTIVENESS OF PROGRAM COMBINING CHAKRAYOGA AND MEDITATION ON THE PHYSICAL HEALTH AND DISEASE-RELATED FACTORS AND PSYCHOLOGICAL FACTORS OF PEOPLE. METHODS NINETY-SEVEN SUBJECTS (32-83 YEARS OLD) WHO HAD FREE FROM PRIOR EXPERIENCES IN MEDITATION PROGRAMS OR CHAKRAYOGA TRAINING COURSES WERE ASSIGNED TO EITHER THE EXPERIMENTAL GROUP (EXP) (45 SUBJECTS; 13 MALE SUBJECTS AND 32 FEMALE SUBJECTS; AVERAGE AGE OF 60.67 YEARS, SD=11.09 YEARS) OR THE CONTROL GROUP (CONT) OF REMAINING SUBJECTS (52 SUBJECTS; 14 MALE SUBJECTS AND 38 FEMALE SUBJECTS; AVERAGE AGE OF 61.58 YEARS, SD=9.70 YEARS). SUBJECTS IN THE EXP PARTICIPATED IN THE CHAKRAYOGA MEDITATION PROGRAM FOR TWICE A WEEK FOR 2 H DURING 6 WEEKS IN EACH SESSION CONSISTED OF 1 H OF CHAKRAYOGA AND 1 H OF MEDITATION. THE MEASUREMENTS IN THIS STUDY INCLUDED THE MINDFULNESS, STRESS RESPONSE, SUBJECTIVE QUALITY OF LIFE, MEDICAL SYMPTOM CHECKLIST, DIFFICULTY IN EMOTIONAL REGULATION AND OBJECTIVE OF LIFE AND SENSE OF CONTROL. RESULTS RESULTS REVEALED THAT PARTICIPANTS IN THE EXP REPORTED SIGNIFICANTLY MORE RELIEF OF MINDFULNESS, STRESS RESPONSE, SUBJECTIVE QUALITY OF LIFE AND MEDICAL SYMPTOM CHECKLIST THAN THOSE IN THE CONT. CONCLUSIONS THESE FINDINGS PROVIDE EVIDENCE THAT THE CHAKRAYOGA MEDITATION PROGRAM CAN HELP RELIEVE THE PHYSICAL HEALTH AND DISEASE-RELATED FACTORS AND PSYCHOLOGICAL FACTORS. 2019 8 295 31 AGE RELATED DIFFERENCES OF SELECTED HATHA YOGA PRACTICES ON ANTHROPOMETRIC CHARACTERISTICS, MUSCULAR STRENGTH AND FLEXIBILITY OF HEALTHY INDIVIDUALS. BACKGROUND: PHYSIOLOGICAL BENEFITS OF YOGA ON VOLUNTEERS OF A PARTICULAR AGE GROUP ARE AVAILABLE. HOWEVER, REPORTS ON EFFICACY OF A SPECIFIC YOGA PACKAGE ON THE POPULACE OF DIFFERENT AGE GROUPS FROM SIMILAR OCCUPATIONAL BACKGROUND IS STILL VERY LIMITED. THEREFORE, THE PRESENT STUDY WAS CONDUCTED TO APPRAISE THE EFFECT OF A SPECIFIC HATHA YOGA PACKAGE ON ANTHROPOMETRIC CHARACTERISTICS, FLEXIBILITY AND MUSCULAR STRENGTH OF HEALTHY INDIVIDUALS OF DIFFERENT AGE GROUPS FROM SIMILAR OCCUPATIONAL TRADE. MATERIALS AND METHODS: A TOTAL OF 71 PARTICIPANTS (GROUP ALL) FROM INDIAN AIR FORCE GROUND PERSONNEL VOLUNTEERED AND AGE WISE DIVIDED INTO 3 GROUPS - (I) GROUP I (GR. - I) (N1 = 27, 20-29 YEARS), (II) GROUP II (GR. - II) (N2 = 21, 30-39 YEARS) AND (III) GROUP III (GR. - III) (N3 = 23, 40-49 YEARS). ALL THE PARTICIPANTS UNDERGONE SELECTED HATHA YOGA TRAINING FOR 1 H DAILY FOR A PERIOD OF 12 WEEKS. PARAMETERS WERE RECORDED BEFORE AND AFTER THE TRAINING. PRE AND POST TRAINING DIFFERENCES WERE ASSESSED BY STUDENT'S T-TEST. RESULTS: BODY WEIGHT (ALL, GR. - II AND GR. - III [ALL P < 0.05]), BODY MASS INDEX (GR. - II AND GR. - III [BOTH P < 0.01]) AND FAT% (GR. - II AND III [BOTH P < 0.05]) WERE DECREASED SIGNIFICANTLY. NECK CIRCUMFERENCE WAS INCREASED SIGNIFICANTLY IN GR. - I (P < 0.05) BUT DECREASED SIGNIFICANTLY IN GR. - III (P < 0.05). CHEST CIRCUMFERENCE (ALL (P < 0.001), IN GR. - I AND II [BOTH P < 0.05]), GRIP STRENGTH (ALL [LEFT: P < 0.01 AND RIGHT: P < 0.05], IN GR. - I [LEFT: P < 0.05 AND RIGHT: P < 0.01], IN GR. - II [RIGHT: P < 0.05] AND IN GR. - III [LEFT: P < 0.05 AND RIGHT: P < 0.01]), BACK LEG STRENGTH (GROUP WISE P < 0.001, P < 0.05, P < 0.01 AND P < 0.05 RESPECTIVELY) AND FLEXIBILITY (ALL P < 0.001) WERE INCREASED SIGNIFICANTLY. SUMMARY AND CONCLUSION: HATHA YOGA CAN IMPROVE ANTHROPOMETRIC CHARACTERISTICS, MUSCULAR STRENGTH AND FLEXIBILITY AMONG VOLUNTEERS OF DIFFERENT AGE GROUP AND CAN ALSO BE HELPFUL IN PREVENTING AND ATTENUATING AGE RELATED DETERIORATION OF THESE PARAMETERS. 2015 9 1971 48 SHORT-TERM EFFECT OF ADD ON BELL PEPPER (CAPSICUM ANNUUM VAR. GROSSUM) JUICE WITH INTEGRATED APPROACH OF YOGA THERAPY ON BLOOD GLUCOSE LEVELS AND CARDIOVASCULAR FUNCTIONS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS: A RANDOMIZED CONTROLLED STUDY. BACKGROUND: TYPE 2 DIABETES MELLITUS (T2DM) IS A MAJOR GLOBAL HEALTH PROBLEM. THOUGH VARIOUS STUDIES HAVE REPORTED THE BENEFICIAL EFFECT OF YOGA IN PATIENT WITH T2DM, THERE IS A LACK OF STUDY IN COMBINATION WITH BELL PEPPER AND YOGA. HENCE, THE PRESENT STUDY AIMS AT EVALUATING SHORT-TERM EFFECT OF ADD ON BELL PEPPER JUICE WITH INTEGRATED APPROACH OF YOGA THERAPY (IAYT) ON BLOOD GLUCOSE LEVELS AND CARDIOVASCULAR VARIABLES IN PATIENTS WITH T2DM. MATERIALS AND METHODS: FIFTY T2DM SUBJECTS WITH THE AGE VARIED FROM 34 TO 69-YEARS WERE RECRUITED AND RANDOMLY DIVIDED INTO EITHER STUDY GROUP OR CONTROL GROUP. THE STUDY GROUP RECEIVED 100-ML OF BELL PEPPER JUICE (TWICE/DAY) ALONG WITH IAYT WHILE THE CONTROL GROUP RECEIVED ONLY IAYT FOR 4-CONSECUTIVE DAYS. BASELINE AND POST-TEST ASSESSMENTS WERE TAKEN BEFORE AND AFTER THE INTERVENTION. STATISTICAL ANALYSIS WAS PERFORMED USING STATISTICAL PACKAGE FOR THE SOCIAL SCIENCES, VERSION-16. RESULTS: RESULTS OF THIS STUDY SHOWED NO SIGNIFICANT DIFFERENCE IN OVERALL (FASTING AND POST PRANDIAL) BLOOD GLUCOSE LEVEL IN THE STUDY GROUP COMPARED WITH CONTROL GROUP. HOWEVER, A SIGNIFICANT REDUCTION IN POST PRANDIAL BLOOD GLUCOSE (PPBG), SYSTOLIC BLOOD PRESSURE (SBP), PULSE PRESSURE (PP), RATE PRESSURE PRODUCT (RPP) AND DOUBLE PRODUCT (DO-P) WAS OBSERVED IN THE STUDY GROUP COMPARED WITH CONTROL GROUP. CONCLUSION: RESULTS OF THIS STUDY SUGGEST THAT THOUGH AN ADDITION OF 100-ML OF BELL PEPPER JUICE (TWICE/DAY) ALONG WITH IAYT IS NOT MORE EFFECTIVE IN REDUCING FASTING BLOOD GLUCOSE, IT MAY BE MORE EFFECTIVE IN REDUCING PPBG, SBP, PP, RPP AND DO-P THAN IAYT ALONE. 2017 10 1019 32 EFFECTS OF WEEKLY ONE-HOUR HATHA YOGA THERAPY ON RESILIENCE AND STRESS LEVELS IN PATIENTS WITH SCHIZOPHRENIA-SPECTRUM DISORDERS: AN EIGHT-WEEK RANDOMIZED CONTROLLED TRIAL. OBJECTIVE: TO EXAMINE THE EFFECTS OF HATHA YOGA THERAPY ON RESILIENCE, BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) LEVELS, AND SALIVARY ALPHA AMYLASE (SAA) ACTIVITY IN PATIENTS WITH SCHIZOPHRENIA-SPECTRUM DISORDERS. DESIGN AND PARTICIPANTS: SINGLE-BLINDED, RANDOMIZED CONTROLLED STUDY IN WHICH OUTPATIENTS WITH SCHIZOPHRENIA OR RELATED PSYCHOTIC DISORDERS (ACCORDING TO INTERNATIONAL CLASSIFICATION OF DISEASES, 10TH REVISION) WERE RANDOMLY ASSIGNED TO A YOGA OR A CONTROL GROUP. SETTING: NOVEMBER 2012-APRIL 2013 AT YAMANASHI PREFECTURAL KITA HOSPITAL, JAPAN. INTERVENTIONS: IN THE YOGA GROUP, PATIENTS RECEIVED WEEKLY 1-HOUR HATHA YOGA SESSIONS, IN ADDITION TO REGULAR TREATMENT, FOR 8 WEEKS. THOSE IN THE CONTROL GROUP UNDERWENT REGULAR TREATMENT, WHICH INCLUDED A DAYCARE REHABILITATION PROGRAM. OUTCOME MEASURES: ASSESSMENTS INCLUDED THE 25-ITEM RESILIENCE SCALE (RS), POSITIVE AND NEGATIVE SYNDROME SCALE (PANSS), PLASMA AND SALIVARY BDNF LEVEL, AND SAA ACTIVITY. RESULTS: FIFTY PATIENTS PARTICIPATED (25 IN EACH GROUP; MEAN AGE+/-STANDARD DEVIATION, 50.9+/-11.3 YEARS; MEAN DURATION OF ILLNESS, 25.0+/-10.3 YEARS; MEAN TOTAL PANSS SCORE, 78.2+/-17.3). NO SIGNIFICANT DIFFERENCES IN CHANGES IN ANY VARIABLE FROM BASELINE TO WEEK 8 WERE FOUND BETWEEN THE TWO GROUPS (CHANGES IN THE YOGA GROUP VERSUS THE CONTROL GROUP: RS SCORE, -1.6+/-19.9 VERSUS 0.3+/-17.2; PANSS SCORE, 0.5+/-12.0 VERSUS 5.0+/-15.6; PLASMA BDNF, 41.6+/-377.0 PG/DL VERSUS 73.4+/-346.0 PG/DL; SAA, -26.2+/-72.6 KU/L VERSUS -13.8+/-68.0 KU/L, RESPECTIVELY). CONCLUSIONS: ADJUNCT YOGA THERAPY SHOWED NO POSITIVE CHANGES IN RESILIENCE LEVEL OR STRESS MARKERS. DURATION AND INTENSITY OF YOGA SESSIONS AND THE FOCUS ON PATIENTS WITH CHRONIC ILLNESS MAY EXPLAIN THE NEGATIVE OBSERVATIONS IN LIGHT OF PAST POSITIVE EVIDENCE REGARDING YOGA THERAPY. 2014 11 2290 43 THERAPEUTIC EFFECT OF YOGA IN PATIENTS WITH HYPERTENSION WITH REFERENCE TO GST GENE POLYMORPHISM. BACKGROUND: HYPERTENSION, A CHRONIC MEDICAL CONDITION OF INCREASED BLOOD PRESSURE, IS A SERIOUS PUBLIC HEALTH PROBLEM. ENVIRONMENTAL AND GENETIC RISK FACTORS ARE KNOWN TO PREDISPOSE TO HYPERTENSION. THE PRESENT STUDY WAS DESIGNED TO INVESTIGATE THE ASSOCIATION OF GLUTATHIONE S-TRANSFERASE (GST) GENE POLYMORPHISM WITH OXIDATIVE STRESS IN HYPERTENSIVE PATIENTS AND THE POSSIBLE BENEFICIAL EFFECT OF YOGA ON THEM. MATERIALS AND METHODS: SIXTY (60) HYPERTENSIVE INDIVIDUALS, BETWEEN 30 AND 60 YEARS OF AGE, WERE DIVIDED INTO TWO GROUPS OF 30 EACH. THE YOGA GROUP WAS SUBJECTED TO 50-60 MINUTES OF YOGIC PRACTICES DAILY FOR 42 DAYS, WHILE THE CONTROL GROUP INCLUDED THE REMAINING 30 AGE- AND SEX-MATCHED HYPERTENSIVE INDIVIDUALS. GST GENE POLYMORPHISM WAS ANALYZED USING MULTIPLE ALLELE SPECIFIC POLYMERASE CHAIN REACTION, AND OXIDATIVE STRESS PARAMETERS WERE ASSESSED BIOCHEMICALLY. RESULTS: ASSESSMENT OF BLOOD PRESSURE SHOWED A STATISTICALLY SIGNIFICANT THOUGH MODEST REDUCTION (P<0.05) IN THE YOGA GROUP AS COMPARED TO THE CONTROL GROUP. MALONDIALDEHYDE WAS OBSERVED TO BE SIGNIFICANTLY LOW (P<0.05), WHILE ANTIOXIDANT CAPACITY IN THE FORM OF GST SHOWED AN INCREASING TREND AND FERRIC-REDUCING ABILITY OF PLASMA WAS SIGNIFICANTLY INCREASED (P<0.05) IN THE SUBJECTS WHO PRACTICED YOGA. CONCLUSIONS: IN CONCLUSION, YOGA HAS BEEN FOUND TO DECREASE BLOOD PRESSURE AS WELL AS THE LEVELS OF OXIDATIVE STRESS IN PATIENTS WITH HYPERTENSION. 2013 12 527 46 COMPARISON OF LYMPHOCYTE APOPTOTIC INDEX AND QUALITATIVE DNA DAMAGE IN YOGA PRACTITIONERS AND BREAST CANCER PATIENTS: A PILOT STUDY. BACKGROUND: YOGA IS FOUND TO BE EFFECTIVE IN REDUCING STRESS LEVELS AND RADIATION-INDUCED DNA DAMAGE, AND IMPROVING THE QUALITY OF LIFE, IN BREAST CANCER PATIENTS. THE PRESENT STUDY WAS AIMED AT COMPARING THE APOPTOTIC INDEX (AI) AND DNA DAMAGE OF ADVANCED YOGA PRACTITIONERS WITH THOSE OF BREAST CANCER PATIENTS. MATERIALS AND METHODS: THIS CROSS-SECTIONAL PILOT STUDY COMPARED THREE GROUPS (N = 9 EACH) OF AGE-MATCHED SUBJECTS VIZ. (1) CARCINOMA BREAST PATIENTS IN STAGE II OR III UNDERGOING RADIATION THERAPY AFTER COMPLETING THREE CYCLES OF CHEMOTHERAPY; (2) SENIOR YOGA PRACTITIONERS WHO WERE PRACTICING ASANAS, PRANAYAMA AND MEDITATION DAILY FOR MORE THAN 10 YEARS; AND (3) NORMAL HEALTHY VOLUNTEERS. PERIPHERAL BLOOD LYMPHOCYTES WERE ISOLATED, AND QUALITATIVE DNA DAMAGE (QDD) AND AI WERE EVALUATED BY SINGLE-CELL GEL ELECTROPHORESIS ASSAY. APPROXIMATELY 500 CELLS WERE COUNTED IN EACH CASE. NUMBER OF CELLS THAT WERE NORMAL, UNDERGOING APOPTOSIS, AND WITH DNA DAMAGE WERE CATEGORIZED AND PERCENTAGES WERE CALCULATED. RESULTS: DATA BEING NORMALLY DISTRIBUTED, ONE-WAY ANALYSIS OF VARIANCE (ANOVA) SHOWED SIGNIFICANT INTERACTION BETWEEN GROUPS IN AI (P = 0.016) AND QDD (P = 0.045). ON POST-HOC ANALYSIS USING SCHEFFE TEST, AI WAS SIGNIFICANTLY LOWER IN NON-YOGA VOLUNTEERS AS COMPARED WITH THE BREAST CANCER GROUP (P = 0.019) AND QDD WAS SIGNIFICANTLY LOWER IN YOGA PRACTITIONERS WHEN COMPARED WITH NON-YOGA VOLUNTEERS (P = 0.047). CONCLUSION: CELLULAR DYSFUNCTION (QDD) REQUIRES RESTORATIVE MECHANISMS (AI) TO RESTORE THE SYSTEM TO A BALANCE. THE RESULTS OF THIS PILOT STUDY SHOW TRENDS, WHICH INDICATE THAT IN ILL-HEALTH, THERE IS INADEQUATE RESTORATIVE MECHANISMS (AI) ALTHOUGH DYSFUNCTION (QDD) IS HIGH. THROUGH REGULAR PRACTICE OF YOGA, CELLULAR DYSFUNCTION CAN BE LOWERED, THUS NECESSITATING REDUCED RESTORATIVE MECHANISMS. AI AND QDD COULD ALSO BE USEFUL INDICATORS FOR PREDICTING THE THREE ZONES OF HEALTH VIZ. DISEASE, HEALTH, AND POSITIVE HEALTH. 2013 13 1176 39 EVALUATION OF GANDHAKADI YOGA AS AN ADJUVANT THERAPY IN THE MANAGEMENT OF BEEJADUSHTIJANYA PANDU (THALASSEMIA MAJOR). INTRODUCTION: THALASSEMIA MAJOR IS A MALIGNANT TYPE OF GENETIC DISORDER AND IRON OVERLOAD IS THE MAIN COMPLICATION OF THE DISEASE WHICH RESULTS DUE TO FREQUENT BLOOD TRANSFUSIONS. GANDHAKADI YOGA HAS BEEN PROVED EFFECTIVE AGAINST IRON OVERLOAD IN EXPERIMENTAL STUDIES AND PILOT VOLUNTARY STUDY, HENCE, TAKEN FOR CLINICAL EVALUATION IN THE PRESENT STUDY. AIM: THE AIM OF THIS STUDY IS TO EVALUATE THE EFFICACY OF GANDHAKADI YOGA AS AN ADJUVANT THERAPY IN THE MANAGEMENT OF THALASSEMIA MAJOR. MATERIALS AND METHODS: A TOTAL OF 46 PATIENTS OF AGE GROUP 2-12 YEARS WERE REGISTERED AND RANDOMLY DIVIDED INTO TWO GROUPS. GROUP A (TRIAL GROUP-GANDHAKADI YOGA WITH BLOOD TRANSFISION (BT)) AND GROUP B (CONTROL GROUP-WITH BT AND IRON CHELATION THERAPY). THE ASSESSMENT WAS DONE BASED ON THE SUBJECTIVE AND OBJECTIVE PARAMETERS AFTER12 WEEKS OF TREATMENT, WITH A FOLLOW-UP OF 12 WEEKS. THE DATA OBTAINED IN CLINICAL STUDY WAS ANALYZED USING STUDENT'S "T" TEST. RESULTS: TRIAL DRUG PROVIDED HIGHLY SIGNIFICANT RESULT (P < 0.001) IN MOST OF THE SUBJECTIVE PARAMETERS AND BT INTERVAL WAS PROLONGED. IN GROUP A, THE MAXIMUM IMPROVEMENT WAS FOUND IN THREE PATIENTS (13.04%); MODERATE IMPROVEMENT IN 15 PATIENTS (65.22%) AND MILD IMPROVEMENT IN FIVE PATIENTS (21.74%). NO ADVERSE DRUG REACTION WAS REPORTED DURING THE CLINICAL STUDY. CONCLUSION: GANDHAKADI YOGA PROVIDED BETTER RESULTS THAN CONTROL IN SUBJECTIVE AND OBJECTIVE PARAMETERS, BT INTERVAL AND GENERAL HEALTH STATUS, HENCE, HAS AN EFFECTIVE ROLE AS AN ADJUVANT IN THE MANAGEMENT OF THALASSEMIA MAJOR. 2016 14 2161 32 THE EFFECTS OF YOGA AMONG ADULTS WITH TYPE 2 DIABETES: A SYSTEMATIC REVIEW AND META-ANALYSIS. THE PURPOSE OF THIS META-ANALYSIS WAS TO EXAMINE THE EFFECTS OF YOGA FOR GLYCEMIC CONTROL AMONG ADULTS WITH TYPE 2 DIABETES (T2DM). COMPREHENSIVE ELECTRONIC DATABASES SEARCHES LOCATED 2559 UNIQUE STUDIES WITH RELEVANT KEY TERMS. STUDIES WERE INCLUDED IF THEY (1) EVALUATED A YOGA INTERVENTION TO PROMOTE T2DM MANAGEMENT, (2) USED A COMPARISON GROUP, (3) REPORTED AN OBJECTIVE MEASURE OF GLYCEMIC CONTROL AT POST-INTERVENTION, AND (4) HAD FOLLOW-UP LENGTH OR POST-TEST OF AT LEAST 8WEEKS FROM BASELINE. INDEPENDENT RATERS CODED PARTICIPANT, DESIGN AND METHODOLOGICAL CHARACTERISTICS AND INTERVENTION CONTENT. SUMMARY EFFECT SIZES AND 95% CONFIDENCE INTERVALS (CI) WERE CALCULATED. TWENTY-THREE STUDIES WITH 2473 PARTICIPANTS (MEAN AGE=53YEARS; 43% WOMEN) MET ELIGIBILITY CRITERIA. COMPARED WITH CONTROLS, YOGA PARTICIPANTS WERE SUCCESSFUL IN IMPROVING THEIR HBA1C (D+=0.36, 95% CI=0.16, 0.56; K=16), FBG (D+=0.58, 95% CI=0.40, 0.76; K=20), AND PPBG (D+=0.40, 95% CI=0.23, 0.56; K=14). YOGA WAS ALSO ASSOCIATED WITH SIGNIFICANT IMPROVEMENTS IN LIPID PROFILE, BLOOD PRESSURE, BODY MASS INDEX, WAIST/HIP RATIO AND CORTISOL LEVELS. OVERALL, STUDIES SATISFIED AN AVERAGE OF 41% OF THE METHODOLOGICAL QUALITY (MQ) CRITERIA; MQ SCORE WAS NOT ASSOCIATED WITH ANY OUTCOME (PS >0.05). YOGA IMPROVED GLYCEMIC OUTCOMES AND OTHER RISK FACTORS FOR COMPLICATIONS IN ADULTS WITH T2DM RELATIVE TO A CONTROL CONDITION. ADDITIONAL STUDIES WITH LONGER FOLLOW-UPS ARE NEEDED TO DETERMINE THE LONG-TERM EFFICACY OF YOGA FOR ADULTS WITH T2DM. 2017 15 930 36 EFFECTIVENESS OF YOGA PROGRAM IN THE MANAGEMENT OF DIABETES USING COMMUNITY HEALTH WORKERS IN THE URBAN SLUMS OF BANGALORE CITY: A NON-RANDOMIZED CONTROLLED TRIAL. TRIAL DESIGN: NONRANDOMIZED CONTROLLED TRIAL. METHODS: NONRANDOMIZED CONTROLLED TRIAL. THIS WAS AN INTERVENTIONAL STUDY THAT WAS CONDUCTED IN 4 SLUMS OF BENGALURU. OF THE 256 DIABETES PARTICIPANTS, ONLY 109 PEOPLE AGREED TO PARTICIPATE IN THE PROGRAM. OF 109 PEOPLE, 52 PEOPLE AGREED TO PARTICIPATE IN THE INTERVENTION (AGREED TO LEARN AND PRACTICE YOGA) WHILE THE REMAINING 57 PEOPLE WERE ASSIGNED TO NONINTERVENTION GROUP. RANDOMIZATION AND BLINDING COULD NOT BE DONE. OBJECTIVE AND OUTCOME: THE STUDY WAS CONDUCTED WITH OBJECTIVE OF ASSESSING THE EFFECTIVENESS OF YOGA, PRANAYAMA, AND SUDARSHAN KRIYA IN THE COMMUNITY-BASED MANAGEMENT OF DIABETES MELLITUS. THE PRIMARY OUTCOME VARIABLE WAS HB1AC AND SECONDARY OUTCOME VARIABLES WERE SYSTOLIC BLOOD PRESSURE (SBP), DIASTOLIC BLOOD PRESSURE (DBP), ADHERENCE TO MEDICATION, AND CHANGES IN LIFESTYLE. RESULTS: THE STUDY WAS CONDUCTED FOR 40 DAYS. COMMUNITY HEALTH WORKERS MADE A TOTAL OF 6 VISITS DURING THE STUDY. ALL THE 109 PARTICIPANTS WERE AVAILABLE FOR WEEKLY FOLLOW-UP. THERE WERE NO DROP OUTS AMONG THE STUDY POPULATION. STATISTICALLY SIGNIFICANT CHANGE WAS SEEN IN THE CONSUMPTION OF VEGETABLE (CHI(2) = 15.326, P < 0.005), FRUITS (CHI(2) = 16.207, P < 0.005), SALTY FOOD (CHI(2) = 14.823, P < 0.005), BAKERY FOOD (CHI(2) = 10.429, P < 0.005) AND FRIED FOOD (CHI(2) = 15.470, P < 0.005), ADHERENCE TO METFORMIN (CHI(2) = 41.780, P < 0.005) AND OTHER MEDICATION(CHI(2) = 21.871, P < 0.005) AND PROPORTION OF PATIENTS WITH DBP UNDER CONTROL (CHI(2) = 9.396, P < 0.005) AND PROPORTION OF PEOPLE WITH GLUCOSE RANDOM BLOOD SUGAR UNDER CONTROL (CHI(2) = 29.693, P < 0.005) BETWEEN THE TWO GROUPS FOLLOWING THE INTERVENTION. STATISTICALLY SIGNIFICANT CHANGE WAS ALSO SEEN IN THE PROPORTION OF PEOPLE WITH SBP/DBP