1 1667 156 NEUROCHEMICAL AND NEUROANATOMICAL PLASTICITY FOLLOWING MEMORY TRAINING AND YOGA INTERVENTIONS IN OLDER ADULTS WITH MILD COGNITIVE IMPAIRMENT. BEHAVIORAL INTERVENTIONS ARE BECOMING INCREASINGLY POPULAR APPROACHES TO AMELIORATE AGE-RELATED COGNITIVE DECLINE, BUT THEIR UNDERLYING NEUROBIOLOGICAL MECHANISMS AND CLINICAL EFFICIENCY HAVE NOT BEEN FULLY ELUCIDATED. THE PRESENT STUDY EXPLORED BRAIN PLASTICITY ASSOCIATED WITH TWO BEHAVIORAL INTERVENTIONS, MEMORY ENHANCEMENT TRAINING (MET) AND A MIND-BODY PRACTICE (YOGIC MEDITATION), IN HEALTHY SENIORS WITH MILD COGNITIVE IMPAIRMENT (MCI) USING STRUCTURAL MAGNETIC RESONANCE IMAGING (S-MRI) AND PROTON MAGNETIC RESONANCE SPECTROSCOPY ((1)H-MRS). SENIOR PARTICIPANTS (AGE >/=55 YEARS) WITH MCI WERE RANDOMIZED TO THE MET OR YOGIC MEDITATION INTERVENTIONS. FOR BOTH INTERVENTIONS, PARTICIPANTS COMPLETED EITHER MET TRAINING OR KUNDALINI YOGA (KY) FOR 60-MIN SESSIONS OVER 12 WEEKS, WITH 12-MIN DAILY HOMEWORK ASSIGNMENTS. GRAY MATTER VOLUME AND METABOLITE CONCENTRATIONS IN THE DORSAL ANTERIOR CINGULATE CORTEX (DACC) AND BILATERAL HIPPOCAMPUS WERE MEASURED BY STRUCTURAL MRI AND (1)H-MRS AT BASELINE AND AFTER 12 WEEKS OF TRAINING. METABOLITES MEASURED INCLUDED GLUTAMATE-GLUTAMINE (GLX), CHOLINE-CONTAINING COMPOUNDS (CHO, INCLUDING GLYCEROPHOSPHOCHOLINE AND PHOSPHOCHOLINE), GAMMA-AMINOBUTYRIC ACID (GABA), AND N-ACETYL ASPARTATE AND N-ACETYLASPARTYL-GLUTAMATE (NAA-NAAG). IN TOTAL, 11 PARTICIPANTS COMPLETED MET AND 14 COMPLETED YOGIC MEDITATION FOR THIS STUDY. STRUCTURAL MRI ANALYSIS SHOWED AN INTERACTION BETWEEN TIME AND GROUP IN DACC, INDICATING A TREND TOWARDS INCREASED GRAY MATTER VOLUME AFTER THE MET INTERVENTION. (1)H-MRS ANALYSIS SHOWED AN INTERACTION BETWEEN TIME AND GROUP IN CHOLINE-CONTAINING COMPOUNDS IN BILATERAL HIPPOCAMPUS, INDUCED BY SIGNIFICANT DECREASES AFTER THE MET INTERVENTION. THOUGH PRELIMINARY, OUR RESULTS SUGGEST THAT MEMORY TRAINING INDUCES STRUCTURAL AND NEUROCHEMICAL PLASTICITY IN SENIORS WITH MCI. FURTHER RESEARCH IS NEEDED TO DETERMINE WHETHER MIND-BODY INTERVENTIONS LIKE YOGA YIELD SIMILAR NEUROPLASTIC CHANGES. 2016 2 2693 29 YOGA INCREASES THE VOLUME OF THE HIPPOCAMPUS IN ELDERLY SUBJECTS. CONTEXT: THE NEUROBIOLOGICAL EFFECT OF YOGA ON THE CORTICAL STRUCTURES IN THE ELDERLY IS AS YET UNKNOWN. MATERIALS AND METHODS: SEVEN HEALTHY ELDERLY SUBJECTS RECEIVED YOGA INTERVENTION AS AN ADD-ON LIFE-STYLE PRACTICE. MAGNETIC RESONANCE IMAGING SCANS WERE OBTAINED BEFORE AND 6 MONTHS LATER. VOXEL-BASED-MORPHOMETRIC ANALYSES COMPARED THE BRAINS BEFORE AND AFTER THE YOGA. RESULTS: YOGA GROUP WAS FOUND TO HAVE INCREASES IN HIPPOCAMPAL, BUT NOT IN OCCIPITAL GRAY MATTER. CONCLUSION: YOGA HAS POTENTIAL TO REDUCE NEURO-SENESCENCE. SMALL SAMPLE SIZE AND ABSENCE OF THE CONTROL GROUP PREVENT GENERALIZATION OF THE FINDINGS LIMITING ITS TRANSLATIONAL VALUE. 2013 3 2504 40 YOGA ASANA SESSIONS INCREASE BRAIN GABA LEVELS: A PILOT STUDY. OBJECTIVES: THE AIM OF THIS STUDY WAS TO COMPARE CHANGES IN BRAIN GAMMA-AMINOBUTYRIC (GABA) LEVELS ASSOCIATED WITH AN ACUTE YOGA SESSION VERSUS A READING SESSION. IT WAS HYPOTHESIZED THAT AN INDIVIDUAL YOGA SESSION WOULD BE ASSOCIATED WITH AN INCREASE IN BRAIN GABA LEVELS. DESIGN: THIS IS A PARALLEL-GROUPS DESIGN. SETTINGS/LOCATION: SCREENINGS, SCAN ACQUISITIONS, AND INTERVENTIONS TOOK PLACE AT MEDICAL SCHOOL-AFFILIATED CENTERS. SUBJECTS: THE SAMPLE COMPRISED 8 YOGA PRACTITIONERS AND 11 COMPARISON SUBJECTS. INTERVENTIONS: YOGA PRACTITIONERS COMPLETED A 60-MINUTE YOGA SESSION AND COMPARISON SUBJECTS COMPLETED A 60-MINUTE READING SESSION. OUTCOME MEASURES: GABA-TO-CREATINE RATIOS WERE MEASURED IN A 2-CM AXIAL SLAB USING MAGNETIC RESONANCE SPECTROSCOPIC IMAGING IMMEDIATELY PRIOR TO AND IMMEDIATELY AFTER INTERVENTIONS. RESULTS: THERE WAS A 27% INCREASE IN GABA LEVELS IN THE YOGA PRACTITIONER GROUP AFTER THE YOGA SESSION (0.20 MMOL/KG) BUT NO CHANGE IN THE COMPARISON SUBJECT GROUP AFTER THE READING SESSION ( -0.001 MMOL/KG) (T = -2.99, DF = 7.87, P = 0.018). CONCLUSIONS: THESE FINDINGS DEMONSTRATE THAT IN EXPERIENCED YOGA PRACTITIONERS, BRAIN GABA LEVELS INCREASE AFTER A SESSION OF YOGA. THIS SUGGESTS THAT THE PRACTICE OF YOGA SHOULD BE EXPLORED AS A TREATMENT FOR DISORDERS WITH LOW GABA LEVELS SUCH AS DEPRESSION AND ANXIETY DISORDERS. FUTURE STUDIES SHOULD COMPARE YOGA TO OTHER FORMS OF EXERCISE TO HELP DETERMINE WHETHER YOGA OR EXERCISE ALONE CAN ALTER GABA LEVELS. 2007 4 1756 33 PLASTICITY OF VISUAL ATTENTION IN ISHA YOGA MEDITATION PRACTITIONERS BEFORE AND AFTER A 3-MONTH RETREAT. MEDITATION HAS LATELY RECEIVED CONSIDERABLE INTEREST FROM COGNITIVE NEUROSCIENCE. STUDIES SUGGEST THAT DAILY MEDITATION LEADS TO LONG LASTING ATTENTIONAL AND NEURONAL PLASTICITY. WE PRESENT CHANGES RELATED TO THE ATTENTIONAL SYSTEMS BEFORE AND AFTER A 3 MONTH INTENSIVE MEDITATION RETREAT. WE USED THREE BEHAVIORAL PSYCHOPHYSICAL TESTS - A STROOP TASK, AN ATTENTIONAL BLINK TASK, AND A GLOBAL-LOCAL LETTER TASK-TO ASSESS THE EFFECT OF ISHA YOGA MEDITATION ON ATTENTIONAL RESOURCE ALLOCATION. 82 ISHA YOGA PRACTITIONERS WERE TESTED AT THE BEGINNING AND AT THE END OF THE RETREAT. OUR RESULTS SHOWED AN INCREASE IN CORRECT RESPONSES SPECIFIC TO INCONGRUENT STIMULI IN THE STROOP TASK. CONGRUENTLY, A POSITIVE CORRELATION BETWEEN PREVIOUS MEDITATION EXPERIENCE AND ACCURACY TO INCONGRUENT STROOP STIMULI WAS ALSO OBSERVED AT BASELINE. WE ALSO OBSERVED A REDUCTION OF THE ATTENTIONAL BLINK. UNEXPECTEDLY, A NEGATIVE CORRELATION BETWEEN PREVIOUS MEDITATION EXPERIENCE AND ATTENTIONAL BLINK PERFORMANCE AT BASELINE WAS OBSERVED. REGARDING SPATIAL ATTENTION ORIENTATION AS ASSESSED USING THE GLOBAL-LOCAL LETTER TASK, PARTICIPANTS SHOWED A BIAS TOWARD LOCAL PROCESSING. ONLY SLIGHT DIFFERENCES IN PERFORMANCE WERE FOUND PRE- VS. POST- MEDITATION RETREAT. BIASING TOWARD THE LOCAL STIMULI IN THE GLOBAL-LOCAL TASK AND NEGATIVE CORRELATION OF PREVIOUS MEDITATION EXPERIENCE WITH ATTENTIONAL BLINK PERFORMANCE IS CONSISTENT WITH ISHA PRACTICES BEING FOCUSED-ATTENTION PRACTICES. GIVEN THE RELATIVELY SMALL EFFECT SIZES AND THE ABSENCE OF A CONTROL GROUP, OUR RESULTS DO NOT ALLOW CLEAR SUPPORT NOR REJECTION OF THE HYPOTHESIS OF MEDITATION-DRIVEN NEURONAL PLASTICITY IN THE ATTENTIONAL SYSTEM FOR ISHA YOGA PRACTICE. 2013 5 1559 19 LONG-TERM VIHANGAM YOGA MEDITATION AND SCORES ON TESTS OF ATTENTION. ALTHOUGH THE LITERATURE INDICATES THAT MEDITATION HAS BENEFICIAL EFFECTS ON SEVERAL ASPECTS OF HUMAN FUNCTIONING, FEW STUDIES HAVE SPECIFICALLY INVESTIGATED THE EFFECTS OF MEDITATION ON VARIOUS DOMAINS OF ATTENTION. THIS STUDY WAS CONDUCTED TO EXAMINE THE DIFFERENCES IN VARIOUS DOMAINS OF ATTENTION BETWEEN LONG-TERM CONCENTRATIVE MEDITATORS VERSUS MATCHED CONTROLS. 15 PRACTITIONERS OF VIHANGAM YOGA (> 10 YR. EXPERIENCE) WERE ENROLLED IN THE STUDY. CONTROLS MATCHED ON AGE, SEX, AND YEARS OF EDUCATION WERE RECRUITED. BOTH GROUPS WERE ADMINISTERED THE STROOP, TRAIL-MAKING, AND DIGIT SYMBOL SUBSTITUTION TESTS AS WELL AS THE DIGIT FORWARD AND DIGIT BACKWARD TESTS. THE GROUP OF VIHANGAM YOGIS HAD SIGNIFICANTLY BETTER MEAN PERFORMANCE ON ALL TESTS OF ATTENTION. LONG-TERM VIHANGAM YOGA MEDITATION IMPROVES ATTENTION SPAN, PROCESSING SPEED, ATTENTION ALTERNATION ABILITY, AND PERFORMANCE IN INTERFERENCE TESTS. 2010 6 1925 42 ROLE OF YOGA IN ALIENATING THE MEMORY DECLINE AND FRONTAL LOBE METABOLITE CHANGES IN TYPE 2 DIABETES. RECENT RESEARCH STUDIES HAVE ESTABLISHED THE FACT, THAT GLYCOSYLATION IS CAUSING THE MEMORY DECLINE AND THIS IS FURTHER SUPPORTED BY THE ALTERATION OF BRAIN METABOLITE CONCENTRATIONS IN DIABETES. THE PRESENT STUDY IS HYPOTHESIZED THAT YOGA IS HAVING ALIENATING ABILITY OF MEMORY DECLINE AND ALTERATION OF FRONTAL LOBE METABOLITE CONCENTRATIONS, WHICH ARE THE RESULT OF GLYCOSYLATION IN TYPE 2 DIABETES. FIVE TYPE 2 DIABETIC SUBJECTS OF BOTH THE SEX, AGED BETWEEN 35-55 YEARS, WHO PRACTICED YOGA OVER A PERIOD OF SIX MONTHS IN A YOGA INSTITUTE, WERE RECRUITED AS TEST GROUP. AGE AND SEX MATCHED FIVE TYPE 2 DIABETIC SUBJECTS WERE RECRUITED AS CONTROL GROUP, BOTH THE GROUP SUBJECTS ARE ON ORAL HYPOGLYCAEMIC AGENTS. GLYCOSYLATED HAEMOGLOBIN PERCENTAGE WAS ESTIMATED WITH BIO-RAD INSTRUMENT, FRONTAL LOBE METABOLITES WERE ESTIMATED WITH PROTON MAGNETIC RESONANCE SPECTROSCOPY (H-MRS), MEMORY WAS CALCULATED WITH PGI-MEMORY SCALE (PGIMS) THAT IS A PART OF PGI-BATTERY OF BRAIN DYSFUNCTION (PGI-BBD), WHICH IS A NEUROPSYCHOLOGICAL BATTERY. MEAN GLYCOSYLATED HAEMOGLOBIN PERCENTAGE AND MEMORY DYSFUNCTION RATING IN CONTROL AND TEST GROUP SUBJECTS ARE 6.9+/-0.4 & 7.8+/-1.84 (P=0.03), AND 14+/-1& 6+/-1 (P=0.0001) RESPECTIVELY. RIGHT AND LEFT FRONTAL LOBE N-ACETYL ASPARTATE (NAA) AND MYOIONOSITOL (MI) CONCENTRATIONS WERE MORE OR LESS SIMILAR IN BOTH THE GROUPS. YOGA IS HAVING A SIGNIFICANT ROLE IN ALIENATING THE DECLINE IN MEMORY CAUSED BY GLYCOSYLATION IN TYPE 2 DIABETES BUT NOT ON THE ALTERATION OF FRONTAL LOBE NAA AND MI CONCENTRATIONS. 2016 7 441 33 CEREBRAL BLOOD FLOW EFFECTS OF YOGA TRAINING: PRELIMINARY EVALUATION OF 4 CASES. OBJECTIVES: EXPERIENCED PRACTITIONERS OF YOGA HAVE BEEN SHOWN TO ALTER BRAIN FUNCTION, BUT THIS CASE SERIES MEASURED CEREBRAL BLOOD FLOW BEFORE AND AFTER A 12-WEEK TRAINING PROGRAM IN IYENGAR YOGA (IY) FOR NAIVE SUBJECTS. METHODS: ON THE FIRST DAY, EACH OF THE 4 SUBJECTS LISTENED TO THE TEACHER SPEAKING ON THE HISTORY AND BACKGROUND OF THE YOGA PROGRAM WHILE THEY WERE INJECTED WITH 250 MBQ OF (99M)TC-BICISATE AND RECEIVED A SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY SCAN (PRE-PROGRAM BASELINE). SUBJECTS THEN HAD THEIR FIRST IY TRAINING AND WERE INJECTED AND SCANNED WITH 925 MBQ BICISATE WHILE THEY DID THEIR FIRST MEDITATION (PRE-PROGRAM MEDITATION). SUBJECTS THEN UNDERWENT A 12-WEEK TRAINING PROGRAM IN IY AND THEN UNDERWENT THE SAME IMAGING PROTOCOL WITH A POSTPROGRAM BASELINE AND POSTPROGRAM MEDITATION SCAN. BASELINE AND MEDITATION SCANS, BEFORE AND AFTER TRAINING, WERE COMPARED USING PAIRED T TESTS. RESULTS: THERE WERE SIGNIFICANT DECREASES (P < 0.05) BETWEEN THE PRE- AND POSTPROGRAM BASELINE SCANS IN THE RIGHT AMYGDALA, DORSAL MEDIAL CORTEX, AND SENSORIMOTOR AREA. THERE WAS A SIGNIFICANT DIFFERENCE (P < 0.05) IN THE PRE- AND POSTPROGRAM PERCENTAGE CHANGE (I.E., ACTIVATION) IN THE RIGHT DORSAL MEDIAL FRONTAL LOBE, PREFRONTAL CORTEX, AND RIGHT SENSORIMOTOR CORTEX. CONCLUSIONS: THESE INITIAL FINDINGS SUGGEST THE BRAIN EXPERIENCES A "TRAINING EFFECT" AFTER 12 WEEKS OF IY TRAINING. 2009 8 1496 33 INTRACEREBRAL PAIN PROCESSING IN A YOGA MASTER WHO CLAIMS NOT TO FEEL PAIN DURING MEDITATION. WE RECORDED MAGNETOENCEPHALOGRAPHY (MEG) AND FUNCTIONAL MAGNETIC RESONANCE IMAGING (FMRI) FOLLOWING NOXIOUS LASER STIMULATION IN A YOGA MASTER WHO CLAIMS NOT TO FEEL PAIN WHEN MEDITATING. AS FOR BACKGROUND MEG ACTIVITY, THE POWER OF ALPHA FREQUENCY BANDS PEAKING AT AROUND 10 HZ WAS MUCH INCREASED DURING MEDITATION OVER OCCIPITAL, PARIETAL AND TEMPORAL REGIONS, WHEN COMPARED WITH THE NON-MEDITATIVE STATE, WHICH MIGHT MEAN THE SUBJECT WAS VERY RELAXED, THOUGH HE DID NOT FALL ASLEEP, DURING MEDITATION. PRIMARY PAIN-RELATED CORTICAL ACTIVITIES RECORDED FROM PRIMARY (SI) AND SECONDARY SOMATOSENSORY CORTICES (SII) BY MEG WERE VERY WEAK OR ABSENT DURING MEDITATION. AS FOR FMRI RECORDING, THERE WERE REMARKABLE CHANGES IN LEVELS OF ACTIVITY IN THE THALAMUS, SII-INSULA (MAINLY THE INSULA) AND CINGULATE CORTEX BETWEEN MEDITATION AND NON-MEDITATION. ACTIVITIES IN ALL THREE REGIONS WERE INCREASED DURING NON-MEDITATION, SIMILAR TO RESULTS IN NORMAL SUBJECTS. IN CONTRAST, ACTIVITIES IN ALL THREE REGIONS WERE WEAKER DURING MEDITATION, AND THE LEVEL WAS LOWER THAN THE BASELINE IN THE THALAMUS. RECENT NEUROIMAGING AND ELECTROPHYSIOLOGICAL STUDIES HAVE CLARIFIED THAT THE EMOTIONAL ASPECT OF PAIN PERCEPTION MAINLY INVOLVES THE INSULA AND CINGULATE CORTEX. THOUGH WE CANNOT CLEARLY EXPLAIN THIS UNUSUAL CONDITION IN THE YOGA MASTER, A CHANGE OF MULTIPLE REGIONS RELATING TO PAIN PERCEPTION COULD BE RESPONSIBLE, SINCE PAIN IS A COMPLEX SENSORY AND EMOTIONAL EXPERIENCE. 2005 9 1972 38 SHORT-TERM SAHAJA YOGA MEDITATION TRAINING MODULATES BRAIN STRUCTURE AND SPONTANEOUS ACTIVITY IN THE EXECUTIVE CONTROL NETWORK. INTRODUCTION: WHILE CROSS-SECTIONAL STUDIES HAVE SHOWN NEURAL CHANGES IN LONG-TERM MEDITATORS, THEY MIGHT BE CONFOUNDED BY SELF-SELECTION AND POTENTIAL BASELINE DIFFERENCES BETWEEN MEDITATORS AND NON MEDITATORS. PROSPECTIVE LONGITUDINAL STUDIES OF THE EFFECTS OF MEDITATION IN NAIVE SUBJECTS ARE MORE CONCLUSIVE WITH RESPECT TO CAUSAL INFERENCES, BUT RELATED EVIDENCE IS SO FAR LIMITED. METHODS: HERE, WE ASSESSED THE EFFECTS OF A 4-WEEK SAHAJA YOGA MEDITATION TRAINING ON GRAY MATTER DENSITY AND SPONTANEOUS RESTING-STATE BRAIN ACTIVITY IN A GROUP OF 12 MEDITATION-NAIVE HEALTHY ADULTS. RESULTS: COMPARED WITH 30 CONTROL SUBJECTS, THE PARTICIPANTS TO MEDITATION TRAINING SHOWED INCREASED GRAY MATTER DENSITY AND CHANGES IN THE COHERENCE OF INTRINSIC BRAIN ACTIVITY IN TWO ADJACENT REGIONS OF THE RIGHT INFERIOR FRONTAL GYRUS ENCOMPASSING THE ANTERIOR COMPONENT OF THE EXECUTIVE CONTROL NETWORK. BOTH THESE MEASURES CORRELATED WITH SELF-REPORTED WELL-BEING SCORES IN THE MEDITATION GROUP. CONCLUSIONS: THE SIGNIFICANT IMPACT OF A BRIEF MEDITATION TRAINING ON BRAIN REGIONS ASSOCIATED WITH ATTENTION, SELF-CONTROL, AND SELF-AWARENESS MAY REFLECT THE ENGAGEMENT OF COGNITIVE CONTROL SKILLS IN SEARCHING FOR A STATE OF MENTAL SILENCE, A DISTINCTIVE FEATURE OF SAHAJA YOGA MEDITATION. THE MANIFOLD IMPLICATIONS OF THESE FINDINGS INVOLVE BOTH MANAGERIAL AND REHABILITATIVE SETTINGS CONCERNED WITH WELL-BEING AND EMOTIONAL STATE IN NORMAL AND PATHOLOGICAL CONDITIONS. 2019 10 51 32 A COMPARATIVE RANDOMISED CONTROLLED TRIAL OF THE EFFECTS OF BRAIN WAVE VIBRATION TRAINING, IYENGAR YOGA, AND MINDFULNESS ON MOOD, WELL-BEING, AND SALIVARY CORTISOL. THIS RANDOMISED TRIAL COMPARED THE EFFECTS OF BRAIN WAVE VIBRATION (BWV) TRAINING, WHICH INVOLVES RHYTHMIC YOGA-LIKE MEDITATIVE EXERCISES, WITH IYENGAR YOGA AND MINDFULNESS. IYENGAR PROVIDED A CONTRAST FOR THE PHYSICAL COMPONENTS AND MINDFULNESS FOR THE "MENTAL" COMPONENTS OF BWV. 35 HEALTHY ADULTS COMPLETED 10 75-MINUTE CLASSES OF BWV, IYENGAR, OR MINDFULNESS OVER FIVE WEEKS. PARTICIPANTS WERE ASSESSED AT PRE- AND POSTINTERVENTION FOR MOOD, SLEEP, MINDFULNESS, ABSORPTION, HEALTH, MEMORY, AND SALIVARY CORTISOL. BETTER OVERALL MOOD AND VITALITY FOLLOWED BOTH BWV AND IYENGAR TRAINING, WHILE THE BWV GROUP ALONE HAD IMPROVED DEPRESSION AND SLEEP LATENCY. MINDFULNESS PRODUCED A COMPARATIVELY GREATER INCREASE IN ABSORPTION. ALL INTERVENTIONS IMPROVED STRESS AND MINDFULNESS, WHILE NO CHANGES OCCURRED IN HEALTH, MEMORY, OR SALIVARY CORTISOL. IN CONCLUSION, INCREASED WELL-BEING FOLLOWED TRAINING IN ALL THREE PRACTICES, INCREASED ABSORPTION WAS SPECIFIC TO MINDFULNESS, WHILE BWV WAS UNIQUE IN ITS BENEFITS TO DEPRESSION AND SLEEP LATENCY, WARRANTING FURTHER RESEARCH. 2012 11 1603 19 MENTAL DEPRESSION AND KUNDALINI YOGA. IN CASES OF MENTAL DEPRESSION, THE PLASMA SEROTONIN, MELATONIN AND GLUTAMATE LEVELS ARE INCREASED ALONG WITH THE LOWERING OF URINARY - 5 - HYDROXYINDOLE ACETIC ACID, PLASMA MONOAMINE OXIDASE AND CORTISOL LEVELS FOLLOWING THREE AND SIX MONTHS PRACTICE OF KUNDALINI YOGA. THE PULSE RATE AND BLOOD PRESSURE IN THESE PATIENTS ARE ALSO LOWERED AFTER KUNDALINI YOGA PRACTICE. THUS, THE PRACTICE OF KUNDALINI YOGA HELPS TO MAINTAIN A PERFECT HOMEOSTASIS BY BRINGING AN EQUILIBRIUM BETWEEN THE SYMPATHETIC AND PARASYMPATHETIC ACTIVITIES AND IT CAN BE USED AS A NON - MEDICAL MEASURE IN TREATING PATIENTS WITH MENTAL DEPRESSION. 1986 12 2085 37 THE EFFECT OF LONG TERM COMBINED YOGA PRACTICE ON THE BASAL METABOLIC RATE OF HEALTHY ADULTS. BACKGROUND: DIFFERENT PROCEDURES PRACTICED IN YOGA HAVE STIMULATORY OR INHIBITORY EFFECTS ON THE BASAL METABOLIC RATE WHEN STUDIED ACUTELY. IN DAILY LIFE HOWEVER, THESE PROCEDURES ARE USUALLY PRACTICED IN COMBINATION. THE PURPOSE OF THE PRESENT STUDY WAS TO INVESTIGATE THE NET CHANGE IN THE BASAL METABOLIC RATE (BMR) OF INDIVIDUALS ACTIVELY ENGAGING IN A COMBINATION OF YOGA PRACTICES (ASANA OR YOGIC POSTURES, MEDITATION AND PRANAYAMA OR BREATHING EXERCISES) FOR A MINIMUM PERIOD OF SIX MONTHS, AT A RESIDENTIAL YOGA EDUCATION AND RESEARCH CENTER AT BANGALORE. METHODS: THE MEASURED BMR OF INDIVIDUALS PRACTICING YOGA THROUGH A COMBINATION OF PRACTICES WAS COMPARED WITH THAT OF CONTROL SUBJECTS WHO DID NOT PRACTICE YOGA BUT LED SIMILAR LIFESTYLES. RESULTS: THE BMR OF THE YOGA PRACTITIONERS WAS SIGNIFICANTLY LOWER THAN THAT OF THE NON-YOGA GROUP, AND WAS LOWER BY ABOUT 13 % WHEN ADJUSTED FOR BODY WEIGHT (P < 0.001). THIS DIFFERENCE PERSISTED WHEN THE GROUPS WERE STRATIFIED BY GENDER; HOWEVER, THE DIFFERENCE IN BMR ADJUSTED FOR BODY WEIGHT WAS GREATER IN WOMEN THAN MEN (ABOUT 8 AND 18% RESPECTIVELY). IN ADDITION, THE MEAN BMR OF THE YOGA GROUP WAS SIGNIFICANTLY LOWER THAN THEIR PREDICTED VALUES, WHILE THE MEAN BMR OF NON-YOGA GROUP WAS COMPARABLE WITH THEIR PREDICTED VALUES DERIVED FROM 1985 WHO/FAO/UNU PREDICTIVE EQUATIONS. CONCLUSION: THIS STUDY SHOWS THAT THERE IS A SIGNIFICANTLY REDUCED BMR, PROBABLY LINKED TO REDUCED AROUSAL, WITH THE LONG TERM PRACTICE OF YOGA USING A COMBINATION OF STIMULATORY AND INHIBITORY YOGIC PRACTICES. 2006 13 2461 26 YOGA AS A NOVEL ADJUVANT THERAPY FOR PATIENTS WITH IDIOPATHIC INFLAMMATORY MYOPATHIES. CONTEXT: RECENT STUDIES HAVE DEMONSTRATED THAT PHYSICAL ACTIVITY IS WELL TOLERATED BY PATIENTS WITH IDIOPATHIC INFLAMMATORY MYOPATHIES (IIMS) AND CAN HAVE ADDITIONAL BENEFITS AS AN ADJUVANT THERAPY TO PHARMACOLOGIC AGENTS, ESPECIALLY IF STARTED EARLY. TO DATE, NO STUDIES HAVE EXAMINED THE EFFECTS OF YOGA ON PATIENTS WITH IIMS. AIMS: THE AIM OF THIS STUDY WAS TO EVALUATE THE EFFECTS OF YOGA ON SELF-REPORTED DIFFICULTY IN PERFORMING ACTIVITIES OF DAILY LIVING (ADL) AND MUSCLE STRENGTH IN PATIENTS WITH MILD-TO-MODERATE IIMS. SUBJECTS AND METHODS: A LONGITUDINAL COHORT STUDY IN WHICH PARTICIPANTS WERE ASSESSED USING THE MYOSITIS ACTIVITIES PROFILE (MAP) AND MANUAL MUSCLE TESTING (MMT) BEFORE AND AFTER THE COMPLETION OF AN 8-WEEK INSTRUCTOR-GUIDED YOGA COURSE WAS PERFORMED. STATISTICAL ANALYSIS USED: WILCOXON SIGNED-RANKED TEST WAS PERFORMED FOR STATISTICAL ANALYSIS. RESULTS: THE AVERAGE POSTTREATMENT MAP SCORES OF SIX PARTICIPANTS DEMONSTRATED AN INCREASE OF 2.51 POINTS, WHILE THE AVERAGE MMT SCORE OF FOUR PARTICIPANTS DEMONSTRATED AN INCREASE OF 11 POINTS. CONCLUSIONS: THIS STUDY IS THE FIRST STUDY TO DATE TO EXAMINE THE EFFECT OF YOGA AS AN ADJUVANT COMPLEMENTARY THERAPY FOR PATIENTS WITH IIM. CONTINUED RESEARCH SHOULD BE DONE ON THE EFFECT OF YOGA AS AN ADJUVANT THERAPY, FOR IN ADDITION TO INCREASE IN MUSCLE STRENGTH AND ABILITY TO PERFORM ADL, YOGA MAY OFFER POTENTIAL IMPROVEMENTS IN MOOD, MENTAL HEALTH, AND SLEEP. 2021 14 2890 34 YOGA: POTENTIAL BENEFITS FOR PERSONS WHO STUTTER. YOGA HAS BEEN DEMONSTRATED TO MODULATE AUTONOMIC NERVOUS SYSTEM ACTIVITY, DECREASING ANXIETY AND STRESS, AND IMPROVING QUALITY OF LIFE. THIS PRELIMINARY STUDY SOUGHT TO EXAMINE THE USE OF YOGIC TECHNIQUES ON PERSONS WHO STUTTER GIVEN THE INTERACTION BETWEEN PHYSIOLOGICAL AROUSAL/ANXIETY AND STUTTERING THAT CURRENT MULTIFACTORIAL MODELS OF STUTTERING PROPOSE. FOUR PARTICIPANTS (M = 52 YR, SD = 10; 2 FEMALE, 2 MALE), RECRUITED FROM LOCAL STUTTERING SUPPORT GROUPS IN THE GREATER PHILADELPHIA COMMUNITY VOLUNTEERED TO PARTICIPATE. STUTTERING SEVERITY, ANXIETY, AND EXPERIENCES REGARDING STUTTERING AND COMMUNICATION WERE MEASURED AT BASELINE, POST INTERVENTION, AND AT 4 MONTHS FOLLOW-UP. THE PARTICIPANTS ATTENDED GROUP YOGA SESSIONS AND ENGAGED IN HOME PRACTICE. DESCRIPTIVE RESULTS REVEALED THAT PARTICIPANTS SHOWED IMPROVEMENTS ACROSS OUTCOME MEASURES, WITH THE MOST IMPROVEMENT RELATED TO ANXIETY. PARTICIPANTS ALSO REPORTED IMPROVEMENTS IN THEIR PERCEPTIONS ABOUT COMMUNICATION AS PER QUALITATIVE ANALYSIS OF RESPONSES TO THE OPEN-ENDED QUESTIONNAIRES. THE RESULTS SUGGEST THE POTENTIAL BENEFITS OF YOGA FOR PERSONS WHO STUTTER AND WARRANTS FURTHER STUDY USING AN EXPERIMENTAL DESIGN. 2016 15 277 25 ADDITIONAL PRACTICE OF YOGA BREATHING WITH INTERMITTENT BREATH HOLDING ENHANCES PSYCHOLOGICAL FUNCTIONS IN YOGA PRACTITIONERS: A RANDOMIZED CONTROLLED TRIAL. BACKGROUND AND OBJECTIVE: THE PRACTICE OF YOGA IS ASSOCIATED WITH ENHANCED PSYCHOLOGICAL WELLBEING. THE CURRENT STUDY ASSESSED THE CORRELATION BETWEEN THE DURATION OF YOGA PRACTICE WITH STATE MINDFULNESS, MIND-WANDERING AND STATE ANXIETY. ALSO, WE EXAMINED IF AN ADDITIONAL 20 MIN OF YOGA BREATHING WITH INTERMITTENT BREATH HOLDING (EXPERIMENTAL GROUP) FOR 8 WEEKS WOULD AFFECT THESE PSYCHOLOGICAL VARIABLES MORE THAN REGULAR YOGA PRACTICE (CONTROL GROUP) ALONE. METHODS: ONE HUNDRED SIXTEEN SUBJECTS WERE RANDOMLY ASSIGNED TO EXPERIMENTAL (N = 60) AND CONTROL (N = 56) GROUPS. STATE MINDFULNESS ATTENTION AWARENESS SCALE (SMAAS), MIND-WANDERING QUESTIONNAIRE (MWQ) AND STATE ANXIETY INVENTORY WERE ADMINISTERED AT BASELINE AND AT THE END OF 8 WEEKS. RESULTS: BASELINE ASSESSMENT REVEALED A POSITIVE CORRELATION BETWEEN DURATION OF YOGA PRACTICE WITH SMAAS SCORES AND NEGATIVE CORRELATION WITH MWQ AND STATE ANXIETY SCORES. AT THE END OF 8 WEEKS, BOTH GROUPS DEMONSTRATED ENHANCED PSYCHOLOGICAL FUNCTIONS, BUT THE EXPERIMENTAL GROUP RECEIVING ADDITIONAL YOGA BREATHING PERFORMED BETTER THAN THE GROUP PRACTICING YOGA ALONE. CONCLUSION: AN ADDITIONAL PRACTICE OF YOGA BREATHING WITH INTERMITTENT BREATH HOLDING WAS FOUND TO ENHANCE THE PSYCHOLOGICAL FUNCTIONS IN YOUNG ADULT YOGA PRACTITIONERS. 2018 16 1098 48 EFFECTS OF YOGA RESPIRATORY PRACTICE (BHASTRIKA PRANAYAMA) ON ANXIETY, AFFECT, AND BRAIN FUNCTIONAL CONNECTIVITY AND ACTIVITY: A RANDOMIZED CONTROLLED TRIAL. PRANAYAMA REFERS TO A SET OF YOGA BREATHING EXERCISES. RECENT EVIDENCE SUGGESTS THAT THE PRACTICE OF PRANAYAMA HAS POSITIVE EFFECTS ON MEASURES OF CLINICAL STRESS AND ANXIETY. THIS STUDY EXPLORED THE IMPACT OF A BHASTRIKA PRANAYAMA TRAINING PROGRAM ON EMOTION PROCESSING, ANXIETY, AND AFFECT. WE USED A RANDOMIZED CONTROLLED TRIAL DESIGN WITH THIRTY HEALTHY YOUNG ADULTS ASSESSED AT BASELINE AND AFTER 4 WEEKS OF PRANAYAMA PRACTICES. TWO FUNCTIONAL MAGNETIC RESONANCE IMAGING (MRI) PROTOCOLS WERE USED BOTH AT BASELINE AND POST-INTERVENTION: AN EMOTION TASK AS WELL AS A RESTING-STATE ACQUISITION. OUR RESULTS SUGGEST THAT PRANAYAMA SIGNIFICANTLY DECREASED STATES OF ANXIETY AND NEGATIVE AFFECT. THE PRACTICE OF PRANAYAMA ALSO MODULATED THE ACTIVITY OF BRAIN REGIONS INVOLVED IN EMOTIONAL PROCESSING, PARTICULARLY THE AMYGDALA, ANTERIOR CINGULATE, ANTERIOR INSULA, AND PREFRONTAL CORTEX. RESTING-STATE FUNCTIONAL MRI (FMRI) SHOWED SIGNIFICANTLY REDUCED FUNCTIONAL CONNECTIVITY INVOLVING THE ANTERIOR INSULA AND LATERAL PORTIONS OF THE PREFRONTAL CORTEX. CORRELATION ANALYSIS REVEALED THAT CHANGES IN CONNECTIVITY BETWEEN THE VENTROLATERAL PREFRONTAL CORTEX AND THE RIGHT ANTERIOR INSULA WERE ASSOCIATED WITH CHANGES IN ANXIETY. ALTHOUGH IT SHOULD BE NOTED THAT THESE ANALYSES WERE PRELIMINARY AND EXPLORATORY, IT PROVIDES THE FIRST EVIDENCE THAT 4 WEEKS OF B. PRANAYAMA SIGNIFICANTLY REDUCE THE LEVELS OF ANXIETY AND NEGATIVE AFFECT, AND THAT THESE CHANGES ARE ASSOCIATED WITH THE MODULATION OF ACTIVITY AND CONNECTIVITY IN BRAIN AREAS INVOLVED IN EMOTION PROCESSING, ATTENTION, AND AWARENESS. THE STUDY WAS REGISTERED AT HTTPS://WWW.ENSAIOSCLINICOS.GOV.BR/RG/RBR-2GV5C2/(RBR-2GV5C2). 2020 17 2752 32 YOGA PRACTICE IS ASSOCIATED WITH SUPERIOR MOTOR IMAGERY PERFORMANCE. YOGA IS AN ACTIVITY THAT AIMS TO INTEGRATE PHYSICAL, MENTAL AND SPIRITUAL ELEMENTS AND IS AN INCREASINGLY POPULAR APPROACH TO ENHANCING PHYSICAL FITNESS. THE INTEGRATION OF IMAGERY WITHIN YOGA PRACTICE IS CONSIDERED AN IMPORTANT COMPONENT AND MAY BE CRITICAL IN CONTRIBUTING TO THE BENEFITS OF YOGA THAT HAVE BEEN REPORTED. IN THIS STUDY, WE TESTED WHETHER INDIVIDUALS WHO PRACTICE YOGA DEMONSTRATE SUPERIOR PERFORMANCE ON AN OBJECTIVE MEASURE OF IMPLICIT MOTOR IMAGERY. THIRTY-SIX PARTICIPANTS (18 YOGA, 18 NON-YOGA) MATCHED FOR AGE, SEX AND HANDEDNESS, UNDERTOOK THE HAND LATERALITY RECOGNITION TASK; AN OBJECTIVE MEASURE OF IMPLICIT MOTOR IMAGERY PERFORMANCE. ACCURACY AND RESPONSE TIMES WERE GATHERED AND ANALYSED TO DETERMINE ANY GROUP DIFFERENCES AS WELL AS ANY DIFFERENCES RELATING TO THE TYPICAL HALLMARKS OF IMAGERY (I.E. DOMINANCE AND AWKWARDNESS EFFECTS) ON THE TASK. RESPONSE TIMES (RTS) IN THE YOGA GROUP WERE SIGNIFICANTLY FASTER THAN CONTROLS (P < 0.05) AND THERE WAS ALSO A TREND TOWARDS GREATER ACCURACY FOR THE YOGA GROUP (P = 0.073). DOMINANCE EFFECTS (FASTER RESPONSES TO IMAGES CORRESPONDING WITH THE DOMINANT LIMB) AND AWKWARDNESS EFFECTS (FASTER RESPONSES TO IMAGES CORRESPONDING WITH NATURAL COMPARED WITH AWKWARD POSTURES) WERE EVIDENT ACROSS GROUPS, SUPPORTING THE PARTICIPANTS' USE OF MOTOR IMAGERY IN UNDERTAKING THE TASK. ADDITIONALLY, A GROUP X AWKWARDNESS INTERACTION (P < 0.05) REVEALED THAT THE ENHANCED IMAGERY PERFORMANCE FOR THE YOGA GROUP WAS MOST PRONOUNCED FOR AWKWARD POSTURES. THIS IS THE FIRST STUDY TO SHOW THAT YOGA PRACTICE IS ASSOCIATED WITH SUPERIOR MOTOR IMAGERY PERFORMANCE; AN ASSOCIATION THAT MAY BE IMPORTANT IN EXPLAINING THE ESTABLISHED REHABILITATIVE VALUE OF YOGA FOR CHRONIC PAIN. 2017 18 597 33 DEVELOPMENT AND FEASIBILITY TESTING OF A BRIEF YOGA MODULE ON WELL-BEING AND COGNITION OF POSTGRADUATE MENTAL HEALTHCARE STUDENTS IN TERTIARY SETTINGS. BACKGROUND: MENTAL HEALTH-CARE STUDENTS EXPERIENCE STRESS AND BURNOUT DURING THEIR TRAINING PERIOD. YOGA HAS BEEN FOUND TO BE HELPFUL IN IMPROVING ONE'S MENTAL HEALTH AND WELL-BEING. AIM: THE AIM OF THIS STUDY IS TO DEVELOP AND TEST THE FEASIBILITY OF A BRIEF YOGA MODULE FOR POSTGRADUATE MENTAL HEALTH-CARE STUDENTS. METHODS: AMIXED METHOD DESIGN WAS USED. PHASE 1 INVOLVED DEVELOPMENT AND VALIDATION OF THE YOGA MODULE USING THE QUALITATIVE EXPLORATORY METHOD. PHASE II TESTED THE FEASIBILITY OF THE MODULE ON A SAMPLE OF 28 FIRST-YEAR POSTGRADUATE STUDENTS. THESE STUDENTS PARTICIPATED IN A 15-DAY (30 MIN/DAY) BRIEF YOGA MODULE FOR IMPROVING THEIR WELL-BEING AND COGNITION (MIRROR NEURON ACTIVATION [MNA] AND TOWER OF LONDON TASK AS ASSESSED ON DAY 0, DAY 15 (2 WEEKS), AND DAY 30 (4 WEEKS). QUALITATIVE FEEDBACK OF THE STUDENT VOLUNTEERS WAS ALSO RECORDED. RESULTS: SIGNIFICANT IMPROVEMENT IN THE WELL-BEING SCORES WAS OBSERVED IN THE STUDENTS WHO ADHERED TO THE YOGA PRACTICE AFTER 2 WEEKS AND 4 WEEKS. FUNCTIONAL NEAR INFRA-RED SPECTROSCOPY (FNIRS) DATA INDICATED THAT ADHERENTS SHOWED SIGNIFICANT ACTIVATION OF LEFT SOMATOSENSORY REGION OF THE BRAIN AND DEACTIVATION IN THE RIGHT PRIMARY SOMATOSENSORY REGION DURING THE STATIC AND ACTIVE PHASE OF THE MNA TASK, RESPECTIVELY. ADHERENT GROUP SHOWED SIGNIFICANT IMPROVEMENT IN REACTION TIME DURING "ZERO-MOVES" TASKS OF TOWER OF LONDON. THE QUALITATIVE THEMATIC ANALYSIS SHOWED THAT THE MODULE HELPED IMPROVE THE WELL-BEING AND MENTAL HEALTH OF THE STUDENTS. CONCLUSION: THE YOGA PROGRAM WAS FOUND TO HAVE HIGH NEED AND MEDIUM TO HIGH FEASIBILITY. A SYSTEMIC INTEGRATION OF STUDENT WELL-BEING-ORIENTED INTERVENTIONS INCLUDING YOGA IN THE CURRICULUM OF POSTGRADUATE MENTAL HEALTH-CARE COURSES IS ADVOCATED. 2021 19 2137 27 THE EFFECTS OF ACUTE YOGA ON ANXIETY SYMPTOMS IN RESPONSE TO A CARBON DIOXIDE INHALATION TASK IN WOMEN. PURPOSE: WE INVESTIGATED THE EFFICACY OF YOGA FOR IMPROVING COGNITIVE AND PHYSICAL ANXIETY SYMPTOMS, AND ITS POSSIBLE RESPIRATORY MECHANISM, IN HIGH-ANXIOUS WOMEN. METHODS: EIGHTEEN PARTICIPANTS COMPLETED 40MIN OF GUIDED YOGA AND A LIGHT STRETCHING PROTOCOL IN A RANDOMIZED, COUNTERBALANCED ORDER.THE 7.5%CO2-INHALATION TASK WAS ADMINISTERED BEFORE, IMMEDIATELY AFTER AND 1H AFTER THE EXPERIMENTAL CONDITIONS.STATE ANXIETY AND PANIC WERE MEASURED BEFORE AND AFTER EACH INHALATION TASK.TIDAL VOLUME, VENTILATION AND RESPIRATORY RATE WERE MEASURED DURING EVERY 7.5%CO2-INHALATION TASKS. RESULTS: THERE WAS NO SIGNIFICANT 3-WAY INTERACTION(P>.05).THERE WAS A SIGNIFICANT MAIN EFFECT OF CO2-INHALATION TASK ON PANIC AND RESPIRATORY MEASURES(P<.05).WHEN COLLAPSED OVER INHALATION TASK AND CONDITION, THERE WAS A SMALL REDUCTION IN COGNITIVE ANXIETY FROM BASELINE TO IMMEDIATELY POST AND 1-H POST-CONDITION(P<.05). CONCLUSIONS: THERE APPEARS TO BE AN OVERALL EFFECT OF GENERAL PHYSICAL ACTIVITY FOR ATTENUATING ANXIETY COGNITIONS IRRESPECTIVE OF THE PHYSIOLOGICAL CHANGES, INDICATING POSSIBLE DISSOCIATION BETWEEN THE COGNITIVE AND PHYSICAL SYMPTOMS OF ANXIETY AMONG WOMEN WITH ANXIETY SENSITIVITY. 2019 20 1601 38 MEMORY TRAINING PLUS YOGA FOR OLDER ADULTS. PREVIOUS TESTS OF THE SENIORWISE INTERVENTION WITH COMMUNITY-RESIDING OLDER ADULTS THAT WERE DESIGNED TO IMPROVE AFFECT AND COGNITIVE PERFORMANCE WERE SUCCESSFUL AND POSITIVELY AFFECTED THESE OUTCOMES. IN THIS STUDY, WE TESTED WHETHER ADDING YOGA TO THE INTERVENTION WOULD AFFECT THE OUTCOMES. USING A QUASIEXPERIMENTAL PRE-POST DESIGN, WE DELIVERED 12 HOURS OF SENIORWISE MEMORY TRAINING THAT INCLUDED A 30-MINUTE YOGA COMPONENT BEFORE EACH TRAINING SESSION. THE INTERVENTION WAS BASED ON THE FOUR COMPONENTS OF SELF-EFFICACY THEORY: ENACTIVE MASTERY EXPERIENCE, VICARIOUS EXPERIENCE, VERBAL PERSUASION, AND PHYSIOLOGIC AROUSAL. WE RECRUITED 133 OLDER ADULTS BETWEEN THE AGES OF 53 AND 96 YEARS FROM FOUR RETIREMENT COMMUNITIES IN CENTRAL TEXAS. INDIVIDUALS WERE SCREENED AND TESTED AND THEN ATTENDED TRAINING SESSIONS TWO TIMES A WEEK OVER 4 WEEKS. A SEPTUAGENARIAN LICENSED PSYCHOLOGIST TAUGHT THE MEMORY TRAINING, AND A CERTIFIED YOGA INSTRUCTOR TAUGHT YOGA. EIGHTY-THREE PARTICIPANTS COMPLETED AT LEAST 9 HOURS (75%) OF THE TRAINING AND COMPLETED THE POSTTEST. THOSE INDIVIDUALS WHO COMPLETED MADE SIGNIFICANT GAINS IN MEMORY PERFORMANCE, INSTRUMENTAL ACTIVITIES OF DAILY LIVING, AND MEMORY SELF-EFFICACY AND HAD FEWER DEPRESSIVE SYMPTOMS. THIRTEEN INDIVIDUALS ADVANCED FROM POOR TO NORMAL MEMORY PERFORMANCE, AND SEVEN IMPROVED FROM IMPAIRED TO POOR MEMORY PERFORMANCE; THUS, 20 INDIVIDUALS IMPROVED ENOUGH TO ADVANCE TO A HIGHER FUNCTIONING MEMORY GROUP. THE FINDINGS FROM THIS STUDY OF A MEMORY TRAINING INTERVENTION PLUS YOGA TRAINING SHOW THAT THE BENEFITS OF MULTIFACTORIAL INTERVENTIONS HAD ADDITIVE BENEFITS. THE COMBINED TREATMENTS OFFER A UNIQUE MODEL FOR BRAIN HEALTH PROGRAMS AND THE PROMOTION OF NONPHARMACOLOGICAL TREATMENT WITH THE GOALS OF MAINTAINING HEALTHY BRAIN FUNCTION AND BOOSTING BRAIN PLASTICITY. 2015