1 1611 138 METABOLIC DEMANDS OF YOGA AT VARYING TEMPOS AND COMPARED WITH WALKING. BACKGROUND: YOGA IS A POPULAR ALTERNATIVE TO WALKING, BUT THE TEMPO AT WHICH ASANAS MUST BE PERFORMED TO ELICIT COMPARABLE METABOLIC AND CARDIORESPIRATORY DEMANDS IS UNKNOWN. THEREFORE, THE AUTHORS AIM TO COMPARE THE METABOLIC DEMANDS OF MODERATE-INTENSITY WALKING TO SURYA NAMASKAR YOGA PERFORMED AT VARYING TEMPOS. METHODS: INACTIVE OBESE ADULTS WITH LIMITED PRIOR YOGA EXPERIENCE (N = 10) COMPLETED 10 MINUTES OF TREADMILL WALKING AT A SELF-SELECTED PACE (RATING OF PERCEIVED EXERTION = 12-13) AND THREE, 10-MINUTE BOUTS OF YOGA AT A LOW (6 S/POSE; LSUN), MEDIUM (4 S/POSE; MSUN), AND HIGH (3 S/POSE; HSUN) TEMPO WITH 10-MINUTES REST BETWEEN EXERCISE BOUTS. RESULTS: MEAN METABOLIC EQUIVALENTS OBSERVED IN MSUN (3.64 [0.607]), HSUN (4.22 [0.459]), AND TREADMILL (5.29 [1.147]) WERE GREATER THAN 3.0 (P </= .01), BUT NOT LSUN (3.28 [0.529], P = .13). TREADMILL ELICITED GREATER CALORIC AND KILOCALORIC EXPENDITURE (1.36 [0.23] L.MIN-1; 64 [11] KCAL) THAN LSUN (0.87 [0.24] L.MIN-1; 39 [11] KCAL) AND MSUN (1.00 [0.29] L.MIN-1; 45 [13] KCAL) (P </= .01). ABSOLUTE V O2 BETWEEN YOGA TEMPOS WERE NOT DIFFERENT, BUT RELATIVE V O2 WAS HIGHER IN HSUN (14.89 [1.74] ML.MIN-1.KG) VERSUS LSUN (11.39 [1.83] ML.MIN-1.KG) (P = .02). CONCLUSIONS: YOGA CAN MEET (LSUN) OR EXCEED (MSUN AND HSUN) MODERATE-INTENSITY EXERCISE RECOMMENDATIONS. FOR UNFIT OR OBESE POPULATIONS, VARYING TEMPOS OF YOGA PRACTICE MAY SERVE AS A LOWER-IMPACT OPTION FOR BEGINNING AN EXERCISE PROGRAM.	2019	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
2 1323  30 HEMODYNAMIC OBSERVATIONS OF TUMO YOGA PRACTITIONERS IN A HIMALAYAN ENVIRONMENT. BACKGROUND: FEW ATTEMPTS HAVE BEEN MADE TO EVALUATE THE PHYSIOLOGY OF TRADITIONAL EASTERN HEALTH PRACTICES. THE GOAL OF THIS STUDY WAS TO EVALUATE THE HEMODYNAMIC EFFECTS OF THE MYSTERIOUS BUDDHIST PRACTICE OF TUMO. TUMO IS A MEDITATIVE PRACTICE THAT PRODUCES INNER HEAT THROUGH THE ALLEGED CULTIVATION OF BODY ENERGY-CHANNELS. METHODS: THIS STUDY WAS PERFORMED BY MEMBERS OF AN INTERNATIONAL EXPEDITION TO THE HIMALAYAN MOUNTAINS IN THE REPUBLIC OF INDIA. THE STUDY WAS PERFORMED IN AN UNPOPULATED OUTDOOR MOUNTAINOUS AREA AT AN ALTITUDE OF 16,400 FT WITH AMBIENT TEMPERATURES BETWEEN -10 AND -15( DEGREES )C. TWO (2) COHORTS OF SUBJECTS WERE STUDIED: HEALTHY NON-YOGI VOLUNTEERS AND TUMO PRACTITIONERS. ALL OF THE SUBJECTS WERE STRIPPED DOWN TO THEIR UNDERCLOTHES AND EXPOSED TO THE SUBZERO ATMOSPHERIC TEMPERATURES FOR 5 MINUTES. THE VOLUNTEERS WERE THEN PASSIVELY REWARMED WHILE THE TUMO PRACTITIONERS PERFORMED TUMO FOR UP TO 10 MINUTES. BLOOD PRESSURE, HEART RATE, AND STROKE VOLUME INDEX (SVI) AND CARDIAC INDEX WERE MEASURED NONINVASIVELY USING A NICOM HEMODYNAMIC MONITOR, WHILE CAROTID BLOOD FLOW AND BIVENTRICULAR PERFORMANCE WERE DETERMINED ECHOCARDIOGRAPHICALLY AT EACH STAGE OF THE EXPERIMENT. THE TOTAL PERIPHERAL RESISTANCE INDEX (TPRI), LEFT VENTRICULAR EJECTION FRACTION (LVEF), AND TRICUSPID ANNULAR PLANE SYSTOLIC EXCURSION (TAPSE) WERE DETERMINED USING STANDARD FORMULA. RESULTS: FOURTEEN (14) SUBJECTS (SIX VOLUNTEERS AND EIGHT TUMO PRACTITIONERS) COMPLETED THE STUDY. THERE WAS ONE FEMALE SUBJECT IN EACH GROUP. WITH COLD EXPOSURE, THE SVI AND CAROTID BLOOD FLOW DECREASED WHILE THE TPRI INCREASED SIGNIFICANTLY IN BOTH GROUPS. IN THE VOLUNTEER GROUP, THESE CHANGES RETUNED TO BASELINE WITH REWARMING. FOLLOWING TUMO, THE CARDIAC INDEX (4.8+/-0.6 VERSUS 4.0+/-0.5 L/M(2); P<0.01), CAROTID BLOOD FLOW (445+/-127 VERSUS 325+/-100 ML/MIN/M(2), P<0.01), LVEF (68+/-5 VERSUS 64+/-7%; P<0.05) AND TAPSE (2.9+/-0.4 VERSUS 2.4+/-0.5 CM; P<0.01) WERE SIGNIFICANTLY HIGHER WHEN COMPARED WITH BASELINE, WHILE THE TPRI WAS SIGNIFICANTLY LOWER (1786+/-189 VERSUS 2173+/-281; P<0.01). CONCLUSIONS: TUMO WAS ASSOCIATED WITH A HYPERDYNAMIC VASODILATED STATE WITH INCREASED BIVENTRICULAR PERFORMANCE. WE POSTULATE THAT TUMO RESULTS IN A MASSIVE INCREASE IN SYMPATHETIC ACTIVITY WITH ACTIVATION OF BROWN ADIPOSE TISSUE AND MARKED HEAT PRODUCTION. THE INCREASED HEAT PRODUCTION MAY EXPLAIN THE PARADOXICAL VASODILATATION IN TUMO PRACTITIONERS EXPOSED TO SUBZERO TEMPERATURES.	2014	

3 1433  17 IMPROVING THE DEGREE OF PUBIC ARCH POST-YOGA EXERCISE DURING PREGNANCY. YOGA EXERCISES UNDERTAKEN DURING THE MATERNITY PERIOD MAY REDUCE UNPLEASANT SYMPTOMS DURING PREGNANCY AND REDUCE DELIVERY PAIN. FLEXIBILITY OF THE HIP JOINT IMPROVES THE DEGREE OF PUBIC ARCH CREATED IN AN OPEN-LEG POSTURE AND WIDENS THE PELVIC OUTLET REGION, SHORTENING THE TIME REQUIRED FOR DELIVERY AND FACILITATING EASY DELIVERY. THE DEGREE OF PUBIC ARCH IS RELATED TO THE FLEXIBILITY OF THE HIP JOINT. ALTHOUGH MANY STUDIES HAVE SHOWN THE EFFECT OF YOGA EXERCISE DURING PREGNANCY, THE EFFECT ON THE DEGREE OF THE PUBIC ARCH HAS NOT BEEN ELUCIDATED. TO ELUCIDATE WHETHER THE DEGREE OF THE PUBIC ARCH IS IMPROVED BY YOGA EXERCISE DURING PREGNANCY, THIS STUDY ENROLLED 177 PREGNANT SUBJECTS. THE DEGREE OF PUBIC ARCH PRE- AND POST-YOGA EXERCISE WAS MEASURED USING INSTRUMENTS IN AN OPEN-LEG POSTURE (SEATED WITH FEMURS ABDUCTED). THE MEAN PUBIC ARCH PRE- AND POST-YOGA WAS 122.61 AND 127.93 DEGREES, RESPECTIVELY. THE DEGREE OF PUBIC ARCH POST-YOGA SESSIONS WAS SIGNIFICANTLY INCREASED COMPARED WITH PRE-YOGA SESSIONS (P < 0.01). THIS STUDY SHOWED THAT YOGA EXERCISES DURING THE PREGNANCY PERIOD APPEAR TO IMPROVE THE DEGREE OF PUBIC ARCH.	2021	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
4 1013  24 EFFECTS OF ONLINE YOGA AND TAI CHI ON PHYSICAL HEALTH OUTCOME MEASURES OF ADULT INFORMAL CAREGIVERS. AIMS: THIS STUDY AIMED TO INVESTIGATE THE EFFECTS OF ONLINE VINYASA YOGA (VY) AND TAIJIFIT (12 WEEKS) IN INFORMAL CAREGIVERS (>/=18 YEARS OF AGE). METHODS: TWENTY-NINE PARTICIPANTS WERE RANDOMIZED TO TWO GROUPS: VY (N = 16, 55.87 +/- 12.31 YEARS) OR TAIJIFIT (N = 13, 55.07 +/- 12.65 YEARS). MAIN OUTCOME MEASURES: PRIOR TO AND FOLLOWING THE STUDY, ASSESSMENTS WERE MADE FOR MUSCLE STRENGTH (1-RM LEG PRESS, CHEST PRESS, AND HANDGRIP), MUSCLE ENDURANCE (LEG PRESS AND CHEST PRESS; MAXIMAL NUMBER OF REPETITIONS PERFORMED TO FATIGUE AT 80% AND 70% BASELINE 1-RM, RESPECTIVELY), ABDOMINAL ENDURANCE (MAXIMUM NUMBER OF CONSECUTIVE CURL-UPS TO FATIGUE), TASKS OF FUNCTIONALITY (DYNAMIC BALANCE AND WALKING SPEED), AND FLEXIBILITY (SIT AND REACH). RESULTS: THERE WAS A SIGNIFICANT INCREASE OVER TIME FOR MUSCLE STRENGTH, MUSCLE ENDURANCE, TASKS OF FUNCTIONALITY, AND FLEXIBILITY (P = 0.001). THE VY GROUP EXPERIENCED A GREATER IMPROVEMENT IN CHEST PRESS ENDURANCE (VY: PRE 19.25 +/- 5.90, POST 28.06 +/- 7.60 REPS; TAIJIFIT PRE 15.69 +/- 4.49, POST 21.07 +/- 5.85 REPS; P = 0.019) AND ABDOMINAL ENDURANCE (VY: PRE 37.12 +/- 31.26, POST 68.43 +/- 55.07 REPS; TAIJIFIT PRE 19.23 +/- 19.00, POST 32.07 +/- 20.87 REPS; P = 0.034) COMPARED TO THE TAIJIFIT GROUP. CONCLUSIONS: VY AND TAIJIFIT ARE EFFECTIVE FOR IMPROVING MUSCLE STRENGTH AND ENDURANCE, TASKS OF FUNCTIONALITY, AND FLEXIBILITY IN INFORMAL CAREGIVERS. VY LED TO GREATER GAINS IN CHEST PRESS ENDURANCE AND ABDOMINAL CURL-UPS.	2019	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
5 1612  40 METABOLIC ENERGY CONTRIBUTIONS DURING HIGH-INTENSITY HATHA YOGA AND PHYSIOLOGICAL COMPARISONS BETWEEN ACTIVE AND PASSIVE (SAVASANA) RECOVERY. PURPOSE: THE OBJECTIVE OF THIS STUDY WAS TO INVESTIGATE METABOLIC ENERGY CONTRIBUTIONS DURING HIGH-INTENSITY HATHA YOGA (HIHY) AND TO COMPARE CHANGES IN PHYSIOLOGICAL VARIABLES BETWEEN ACTIVE AND PASSIVE RECOVERY METHODS. METHODS: THE STUDY INVOLVED 20 WOMEN YOGA INSTRUCTORS (N = 20) WHO PERFORMED 10 MIN OF HIHY (VIGOROUS SUN SALUTATION). UPON COMPLETION, THEY WERE RANDOMLY ASSIGNED TO EITHER ACTIVE (WALKING; N = 10) OR PASSIVE (SAVASANA; N = 10) RECOVERY GROUPS FOR A PERIOD OF 10 MIN. DURING HIHY, PHYSIOLOGICAL VARIABLES SUCH AS HEART RATE (HRPEAK AND HRMEAN), OXYGEN UPTAKE (VO2PEAK AND VO2MEAN), AND BLOOD LACTATE CONCENTRATIONS (PEAK LA(-)) WERE MEASURED. ENERGETIC CONTRIBUTIONS (PHOSPHAGEN; WPCR, GLYCOLYTIC; WGLY, AND OXIDATIVE; WOXI) IN KJ AND % WERE ESTIMATED USING VO2 AND LA(-) DATA. FURTHERMORE, THE METABOLIC EQUIVALENTS (METS) OF VO2PEAK AND VO2MEAN WERE CALCULATED. TO COMPARE DIFFERENT RECOVERY MODES, HRPOST, DELTAHR, VO2POST, DELTAVO2, RECOVERY LA(-), AND RECOVERY DELTALA(-) WERE ANALYZED. RESULTS: THE RESULTS REVEALED THAT HRPEAK, VO2PEAK, AND PEAK LA(-) DURING HIHY SHOWED NO DIFFERENCES BETWEEN THE TWO GROUPS (P > 0.05). VALUES OF HRPEAK, HRMEAN, METS OF VO2PEAK AND VO2MEAN, AND LA(-) DURING HIHY WERE 95.6% OF HRMAX, 88.7% OF HRMAX, 10.54 +/- 1.18, 8.67 +/-.98 METS, AND 8.31 +/- 2.18 MMOL.L(-1), RESPECTIVELY. FURTHERMORE, WOXI WAS SIGNIFICANTLY HIGHER COMPARED WITH WPCR, WGLY, AND ANAEROBIC CONTRIBUTION (WPCR + WGLY), IN KJ AND % (P < 0.0001). VO2POST AND RECOVERY DELTALA(-) WERE SIGNIFICANTLY HIGHER IN THE ACTIVE RECOVERY GROUP (P < 0.0001, P = 0.0369, RESPECTIVELY). VALUES OF DELTAVO2 AND RECOVERY LA(-) WERE SIGNIFICANTLY LOWER IN THE ACTIVE GROUP COMPARED WITH THE PASSIVE GROUP (P = 0.0115, P = 0.0291, RESPECTIVELY). CONCLUSIONS: THE STUDY CONCLUDED THAT HIGH-INTENSITY HATHA YOGA WHICH WAS PERFORMED FOR 10 MIN IS A SUITABLE OPTION FOR RELATIVELY HEALTHY PEOPLE IN THE MODERN WORKPLACE WHO MAY HAVE HATHA YOGA EXPERIENCE BUT DO NOT HAVE TIME TO PERFORM A PROLONGED EXERCISE. FOLLOWING ACTIVE RECOVERY, THEY CAN PARTICIPATE IN FURTHER HIHY SESSIONS DURING SHORT BREAKS. FURTHERMORE, A FASTER RETURN TO WORK CAN BE SUPPORTED BY PHYSIOLOGICAL RECOVERY.	2021	
                                                                                                                                                                                                                              
6  481  22 CLINICAL EFFICACY OF APAMARGA KSHARA YOGA IN THE MANAGEMENT OF SHVITRA (VITILIGO). INTRODUCTION: VITILIGO IS A PROGRESSIVE, IDIOPATHIC, PIGMENTATION DISORDER OF THE SKIN, CHARACTERIZED BY HYPOPIGMENTED PATCHES. THIS CONDITION IS COMPARED WITH SHVITRA IN AYURVEDA. MANY AYURVEDIC DRUGS ARE BENEFICIAL IN SUCH CASES AND APAMARGA KSHARA YOGA IS ONE AMONG THEM. AIM: TO EVALUATE THE EFFICACY OF APAMARGA KSHARA YOGA IN LEPA AND OINTMENT FORMS IN THE MANAGEMENT OF SHVITRA. MATERIALS AND METHODS: TOTAL 50 PATIENTS OF SHVITRA WERE RANDOMLY GROUPED INTO TWO. PATIENTS REGISTERED IN GROUP A (N = 25) WERE TREATED WITH APAMARGA KSHARA YOGA LEPA AND GROUP B (N = 25) WITH APAMARGA KSHARA YOGA OINTMENT FOR 2 MONTHS. RASAYANA CHURNA (3G) ALONG WITH HONEY AND GHEE WAS GIVEN TWICE DAILY INTERNALLY IN THE BOTH GROUPS. RESULTS: SIGNIFICANT IMPROVEMENT WAS FOUND IN THE SYMPTOMS OF SHVITRA WITH TREATMENT IN BOTH THE GROUPS. THE DIFFERENCE IN BETWEEN THE GROUPS WAS STATISTICALLY INSIGNIFICANT. CONCLUSION: BOTH FORMS OF APAMRAGA KSHARA YOGA ARE EFFECTIVE IN CASES OF SHVITRA AND CAN BE GOOD ALTERNATIVES FOR CONTEMPORARY MEDICINES.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
7  534  27 COMPARISON OF YOGA AND WALKING-EXERCISE ON CARDIAC TIME INTERVALS AS A MEASURE OF CARDIAC FUNCTION IN ELDERLY WITH INCREASED PULSE PRESSURE. OBJECTIVE: ARTERIAL AGING ALONG WITH INCREASED BLOOD PRESSURE(BP) HAS BECOME THE MAJOR CARDIOVASCULAR(CV) RISK IN ELDERLY. THE AIM OF THE STUDY WAS TO COMPARE THE EFFECTS OF YOGA PROGRAM AND WALKING-EXERCISE ON CARDIAC FUNCTION IN ELDERLY WITH INCREASED PULSE PRESSURE (PP). METHODS: AN OPEN LABEL, PARALLEL-GROUP RANDOMIZED CONTROLLED STUDY DESIGN WAS ADOPTED. ELDERLY INDIVIDUALS AGED >/=60 YEARS WITH PP>/=60MMHG WERE RECRUITED FOR THE STUDY. YOGA (STUDY) GROUP (N=30) WAS ASSIGNED FOR YOGA TRAINING AND WALKING (EXERCISE) GROUP (N=30) FOR WALKING WITH LOOSENING PRACTICES FOR ONE HOUR IN THE MORNING FOR 6DAYS IN A WEEK FOR 3 MONTHS. THE OUTCOME MEASURES WERE CARDIAC TIME INTERVALS DERIVED FROM PULSE WAVE ANALYSIS AND ECG: RESTING HEART RATE (RHR), DIASTOLIC TIME(DT), VENTRICULAR EJECTION TIME(LVET), UPSTROKE TIME(UT), EJECTION DURATION INDEX (ED%), PRE-EJECTION PERIOD (PEP), RATE PRESSURE PRODUCT (RPP) AND PERCENTAGE OF MEAN ARTERIAL PRESSURE (%MAP). RESULTS: THE MEAN WITHIN-YOGA GROUP CHANGE IN RHR(BPM) WAS 4.41 (P=0.031), PD(MS): -50.29 (P=0.042), DT(MS): -49.04 (P=0.017), ED%: 2.107 (P=0.001), ES(MMHG/MS): 14.62 (P=0.118), ET(MS): -0.66 (P=0.903), UT(MS): -2.54 (P=0.676), PEP(MS): -1.25 (P=0.11) AND %MAP: 2.08 (P=0.04). THE MEAN WITHIN-CONTROL GROUP CHANGE IN HR (BPM) WAS 0.35 (P=0.887), PD (MS): 11.15(P=0.717), DT (MS): 11.3 (P=0.706), ED%: -0.101 (P=0.936), ES (MMHG/MS): 0.75 (P=0.926), ET(MS): 2.2 (P=0.721), UT(MS):4.7(P=455), PEP (MS): 2.1(P=0.11), %MAP: 0.65 (P=0.451). A SIGNIFICANT DIFFERENCE BETWEEN-GROUP WAS FOUND IN RHR (P=0.036), PD (P=0.02), ED% (P=0.049), LVET (P=0.048), DT (P=0.02) AND RPP (P=0.001). CONCLUSIONS: YOGA PRACTICE FOR 3 MONTHS SHOWED A SIGNIFICANT IMPROVEMENT IN DIASTOLIC FUNCTION WITH A MINIMAL CHANGE IN SYSTOLIC FUNCTION. YOGA IS MORE EFFECTIVE THAN WALKING IN IMPROVING CARDIAC FUNCTION IN ELDERLY WITH HIGH PP.	2017	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
8 1360  25 IMMEDIATE EFFECTS OF YOGA BREATHING WITH INTERMITTENT BREATH HOLDING ON RESPONSE INHIBITION AMONG HEALTHY VOLUNTEERS. BACKGROUND: THERE IS VERY LITTLE EVIDENCE AVAILABLE ON THE EFFECTS OF YOGA-BASED BREATHING PRACTICES ON RESPONSE INHIBITION. THE CURRENT STUDY USED STOP-SIGNAL PARADIGM TO ASSESS THE EFFECTS OF YOGA BREATHING WITH INTERMITTENT BREATH HOLDING (YBH) ON RESPONSE INHIBITION AMONG HEALTHY VOLUNTEERS. MATERIALS AND METHODS: THIRTY-SIX HEALTHY VOLUNTEERS (17 MALES + 19 FEMALES), WITH MEAN AGE OF 20.31 +/- 3.48 YEARS FROM A UNIVERSITY, WERE RECRUITED IN A WITHIN-SUBJECT REPEATED MEASURES (RM) DESIGN. THE RECORDINGS FOR STOP SIGNAL TASK WERE PERFORMED ON THREE DIFFERENT DAYS FOR BASELINE, POST-YBH, AND POST YOGIC BREATH AWARENESS (YBA) SESSIONS. STOP-SIGNAL REACTION TIME (SSRT), MEAN REACTION TIME TO GO STIMULI (GO RT), AND THE PROBABILITY OF RESPONDING ON-STOP SIGNAL TRIALS (P [R/S]) WERE ANALYZED FOR 36 VOLUNTEERS USING RM ANALYSIS OF VARIANCE. RESULTS: SSRT REDUCED SIGNIFICANTLY IN BOTH YBH (218.33 +/- 38.38) AND YBA (213.15 +/- 37.29) GROUPS WHEN COMPARED TO BASELINE (231.98 +/- 29.54). NO SIGNIFICANT CHANGES WERE OBSERVED IN GO RT AND P (R/S). FURTHER, THE CHANGES IN SSRT WERE NOT SIGNIFICANTLY DIFFERENT AMONG YBH AND YBA GROUPS. CONCLUSION: BOTH YBH AND YBA GROUPS WERE FOUND TO ENHANCE RESPONSE INHIBITION IN THE STOP-SIGNAL PARADIGM. YBH COULD BE FURTHER EVALUATED IN CLINICAL SETTINGS FOR CONDITIONS WHERE RESPONSE INHIBITION IS ALTERED.	2018	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
9  808  24 EFFECT OF YOGA ON ARTERIAL STIFFNESS IN ELDERLY SUBJECTS WITH INCREASED PULSE PRESSURE: A RANDOMIZED CONTROLLED STUDY. OBJECTIVE: WE AIMED TO DETERMINE THE EFFECT OF YOGA ON ARTERIAL FUNCTION IN ELDERLY WITH INCREASED PULSE PRESSURE (PP). DESIGN: RANDOMIZED CONTROLLED STUDY WITH TWO PARALLEL GROUPS. PARTICIPANTS: ELDERLY SUBJECTS WITH PP>/=60 MMHG (N=60). INTERVENTIONS: YOGA GROUP (N=30) WAS ASSIGNED FOR YOGA TRAINING AND BRISK-WALKING (BW) GROUP (N=30) FOR BRISK-WALK WITH STRETCHING EXERCISE FOR 1H IN THE MORNING FOR 6 DAYS IN A WEEK FOR 12 WEEKS. MAIN OUTCOME MEASURES: ARTERIAL STIFFNESS MEASURES: BRACHIAL-ANKLE PULSE WAVE VELOCITY (BAPWV), CAROTID-FEMORAL PULSE WAVE VELOCITY (C-F PWV), AORTIC AUGMENTATION INDEX (AIX@75), ARTERIAL STIFFNESS INDEX AT BRACHIAL (BASI) AND TIBIAL ARTERIES (AASI). TOTAL SERUM NITRIC OXIDE CONCENTRATION (NOX) AS AN INDEX OF ENDOTHELIAL FUNCTION. HEART RATE VARIABILITY (HRV) MEASURES: LOW FREQUENCY AND HIGH FREQUENCY IN NORMALIZED UNITS (LFNU, HFNU) AND LF/HF RATIO. RESULTS: THE MEAN BETWEEN-GROUP CHANGE (WITH 95% CI) IN ARTERIAL STIFFNESS: C-F PWV(M/S) [1.25(0.59-1.89); P<0.001], BAPWV(M/S) [1.96(0.76-3.16), P<0.01], AIX@75 [3.07(0.24-5.89), P=0.066], AASI [8.3(4.06-12.53), P<0.001]; ENDOTHELIAL FUNCTION INDEX: NO(MUMOL/L) [-9.03(-14.57 TO -3.47), P<0.001]; SBP(MMHG) [14.23(12.03-16.44), P<0.001], DBP(MMHG) [0.1(-1.95-2.15), P=0.38], PP(MMHG) [14.07(11.2-16.92), P<0.001], MAP(MMHG) [4.7(3.08-6.32), P<0.001]; AND CARDIAC AUTONOMIC FUNCTION: LF(NU) [4.81(1.54-8.08), P<0.01], HF(NU) [-4.13(-7.57 TO -0.69), P<0.01], LF/HF RATIO [0.84(0.3-1.37), P<0.001], INDICATE SIGNIFICANT DIFFERENCE IN EFFECTS OF TWO INTERVENTION ON ARTERIAL STIFFNESS, ENDOTHELIAL FUNCTION, BP AND CARDIAC AUTONOMIC ACTIVITY. THERE WAS SIGNIFICANT CHANGE WITHIN-YOGA GROUP IN VASCULAR FUNCTION, BP AND AUTONOMIC FUNCTION, WHILE NO SIGNIFICANT CHANGE WITHIN-BW GROUP WAS OBSERVED. CONCLUSION: OUR FINDINGS SUGGEST THAT YOGA PROGRAM OFFERED WAS MORE EFFECTIVE THAN BRISK-WALK IN REDUCING ARTERIAL STIFFNESS ALONG WITH BP IN ELDERLY INDIVIDUALS WITH INCREASED PP. YOGA CAN ALSO SIGNIFICANTLY REDUCE SYMPATHETIC ACTIVITY AND IMPROVE ENDOTHELIAL FUNCTION WITH ENHANCEMENT IN BIOAVAILABILITY OF NO.	2015	
                                                                                                                                                                                                                                                                                                                                                       
10 1764  19 POSTNATAL DEVELOPMENT AND REPRODUCTIVE PERFORMANCE OF F1 PROGENY EXPOSED IN UTERO TO AN AYURVEDIC CONTRACEPTIVE: PIPPALIYADI YOGA. PIPPALIYADI YOGA OR PIPPALIYADI VATI IS AN AYURVEDIC CONTRACEPTIVE USED IN INDIA SINCE ANCIENT TIMES. IT IS A COMBINATION OF POWDERED FRUIT BERRIES OF EMBELIA RIBES BURM.F. (MYRSINACEAE), PIPER LONGUM L. (PIPERACEAE) AND BORAX IN EQUAL PROPORTION. THOUGH THE CONTRACEPTIVE POTENTIAL IS KNOWN SINCE ANCIENT TIMES, NO SYSTEMATIC DEVELOPMENTAL TOXICITY STUDIES HAVE BEEN CARRIED OUT. THE PRESENT STUDY WAS CARRIED OUT TO EVALUATE THE POSTNATAL DEVELOPMENTAL TOXICITY AND THE REPRODUCTIVE PERFORMANCE OF THE PROGENY EXPOSED IN UTERO TO PIPPALIYADI. PIPPALIYADI YOGA WAS OBTAINED FROM NATIONAL INSTITUTE FOR PHARMACEUTICAL EDUCATION AND RESEARCH (NIPER), INDIA AND THE DEVELOPMENTAL TOXICITY WAS STUDIED BY ADMINISTERING THREE DOSES, VIZ. 140, 300 AND 700 MG/(KG DAY) TO GRAVID FEMALES FROM DAY 6 TO DAY 16 OF GESTATION. PIPPALIYADI DID NOT HAVE ANY ADVERSE DEVELOPMENTAL EFFECTS WITH LOW DOSES, HOWEVER, WITH THE FIVE TIMES HIGHER DOSE, A DECREASE IN BODY WEIGHT OF THE PUPS WAS OBSERVED. THE REPRODUCTIVE PERFORMANCE OF THE PROGENY BORN TO MOTHERS TREATED WITH PIPPALIYADI WAS NOT SIGNIFICANTLY AFFECTED. THE PRESENT STUDY SUGGESTS THAT IN UTERO EXPOSURE TO PIPPALIYADI DOES NOT HAVE ANY ADVERSE EFFECT ON THE POSTNATAL DEVELOPMENT AND REPRODUCTIVE PERFORMANCE OF THE F(1) PROGENY.	2007	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
11  533  18 COMPARISON OF TWO TAGTEACH ERROR-CORRECTION PROCEDURES TO TEACH BEGINNER YOGA POSES TO ADULTS. TEACHING WITH ACOUSTICAL GUIDANCE INVOLVES AUDITORY FEEDBACK (E.G., A CLICK SOUND WHEN A DESIRED BEHAVIOR OCCURS) AS PART OF A MULTICOMPONENT INTERVENTION KNOWN AS TAGTEACH. TAGTEACH HAS BEEN FOUND TO IMPROVE PERFORMANCE IN SPORT, DANCE, SURGICAL TECHNIQUE, AND WALKING. WE COMPARED THE EFFICACY AND EFFICIENCY OF THE STANDARD TAGTEACH ERROR-CORRECTION PROCEDURE AND A MODIFIED TAGTEACH ERROR-CORRECTION PROCEDURE TO TEACH 4 NOVICE ADULT YOGA PRACTITIONERS BEGINNER YOGA POSES. BOTH ERROR-CORRECTION PROCEDURES WERE EFFECTIVE FOR ALL PARTICIPANTS; HOWEVER, THE RELATIVE EFFICIENCY OF THESE ERROR-CORRECTION PROCEDURES WAS UNCLEAR. RESULTS ARE DISCUSSED IN TERMS OF LIMITATIONS AND CONSIDERATIONS FOR FUTURE RESEARCH.	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
12 1229  24 FEASIBILITY AND IMPACT OF AN 8-WEEK INTEGRATIVE YOGA PROGRAM IN PEOPLE WITH MODERATE MULTIPLE SCLEROSIS-RELATED DISABILITY: A PILOT STUDY. BACKGROUND: THIS PILOT STUDY DETERMINED THE FEASIBILITY OF A SPECIFICALLY DESIGNED 8-WEEK YOGA PROGRAM FOR PEOPLE WITH MODERATE MULTIPLE SCLEROSIS (MS)-RELATED DISABILITY. WE EXPLORED THE PROGRAM'S EFFECT ON QUALITY OF LIFE (QOL) AND PHYSICAL AND MENTAL PERFORMANCE. METHODS: WE USED A SINGLE-GROUP DESIGN WITH REPEATED MEASUREMENTS AT BASELINE, POSTINTERVENTION, AND 8-WEEK FOLLOW-UP. FEASIBILITY WAS EXAMINED THROUGH COST, RECRUITMENT, RETENTION, ATTENDANCE, AND SAFETY. OUTCOMES INCLUDED THE MULTIPLE SCLEROSIS QUALITY OF LIFE INVENTORY (MSQLI), 12-ITEM MULTIPLE SCLEROSIS WALKING SCALE (MSWS-12), TIMED 25-FOOT WALK TEST (T25FW), 6-MINUTE WALK TEST (6MWT), NINE-HOLE PEG TEST (NHPT), FIVE-TIMES SIT-TO-STAND TEST (FTSTS), MULTIDIRECTIONAL REACH TEST (MDRT), MAXIMUM EXPIRATORY PRESSURE, AND PACED AUDITORY SERIAL ADDITION TEST-3'' (PASAT-3''). RESULTS: FOURTEEN PARTICIPANTS COMPLETED THE STUDY. THE PROGRAM WAS FEASIBLE. THERE WERE SIGNIFICANT MAIN EFFECTS ON THE 36-ITEM SHORT FORM HEALTH STATUS SURVEY MENTAL COMPONENT SUMMARY (SF-36 MCS), MODIFIED FATIGUE IMPACT SCALE (MFIS), BLADDER CONTROL SCALE (BLCS), PERCEIVED DEFICITS QUESTIONNAIRE (PDQ), MENTAL HEALTH INVENTORY (MHI), MSWS-12, T25FW, NHPT, PASAT-3'', 6MWT, FTSTS, AND MDRT-BACK. IMPROVEMENTS WERE FOUND ON THE SF-36 MCS, MFIS, BLCS, PDQ, MHI, AND MSWS-12 BETWEEN BASELINE AND POSTINTERVENTION. THE EFFECT ON PDQ PERSISTED AT FOLLOW-UP. IMPROVEMENTS WERE FOUND ON THE T25FW, NHPT, 6MWT, FTSTS, AND MDRT-BACK BETWEEN BASELINE AND POSTINTERVENTION THAT PERSISTED AT FOLLOW-UP. THE PASAT-3'' DID NOT CHANGE BETWEEN BASELINE AND POSTINTERVENTION BUT DID BETWEEN POSTINTERVENTION AND FOLLOW-UP. CONCLUSIONS: THE YOGA PROGRAM WAS SAFE AND FEASIBLE. IMPROVEMENTS IN CERTAIN MEASURES OF QOL AND PERFORMANCE WERE SEEN AT POSTINTERVENTION AND FOLLOW-UP.	2017	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
13 2108  13 THE EFFECT OF YOGA ON PUBORECTALIS PARADOX. NINE PATIENTS WITH SEVERE DEFAECATION DIFFICULTIES PRIMARILY CONSIDERED TO BE DUE TO PUBORECTALIS DYSFUNCTION (PUBORECTALIS PARADOX), VERIFIED BY ELECTROMYOGRAPHY (EMG) OF THE STRIATED ANAL SPHINCTER MUSCLES, WERE OFFERED TRAINING IN YOGIC TECHNIQUES OF RELAXATION AND MUSCLE CONTROL IN ORDER TO CHANGE THE ACTIVITY OF THE PELVIC FLOOR MUSCLES DURING ATTEMPTED DEFAECATION. FIVE PATIENTS COMPLETED THE TRAINING PROGRAM OF 20 2-HOUR SESSIONS AND WERE RE-EXAMINED CLINICALLY AND WITH EMG. ONE PATIENT REGAINED A NORMAL EMG PATTERN BUT NONE OF THE PATIENTS IMPROVED CLINICALLY.	1991	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
14  804  12 EFFECT OF YOGA ON AEROBIC AND ANAEROBIC POWER OF MUSCLES. AEROBIC POWER (VO2 MAX) AND ANAEROBIC POWER WERE ESTIMATED IN MEDICAL STUDENTS BEFORE AND AFTER SIX WEEKS OF YOGIC TRAINING. A SIGNIFICANT INCREASE IN AEROBIC POWER AND A SIGNIFICANT DECREASE IN ANAEROBIC POWER WAS OBSERVED. THIS MAY BE DUE TO CONVERSION OF SOME OF THE FAST TWITCH (F.T.) MUSCLE FIBRES INTO SLOW TWITCH FIBRES (S.T.) DURING YOGIC TRAINING.	1991	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
15 1358  22 IMMEDIATE EFFECT OF YOGA EXERCISES FOR EYES ON THE MACULAR THICKNESS. BACKGROUND: YOGA EXERCISES FOR EYES HAVE BEEN ADVOCATED AS BENEFICIAL TO EYE HEALTH. IN A PREVIOUS STUDY, WE EVALUATED THE EFFECT OF YOGA EXERCISES FOR EYES ON THE INTRAOCULAR PRESSURE (IOP). THE OTHER ASPECTS OF THE EFFECTS OF YOGA EXERCISES FOR EYES TO OCULAR STRUCTURE HAVE NOT BEEN INVESTIGATED YET. AIM: THE AIM OF THIS STUDY IS TO EVALUATE THE EFFECT OF YOGA EXERCISES FOR EYES ON THE MACULAR STRUCTURE USING THE OPTICAL COHERENCE TOMOGRAPHY (OCT) AND OCT ANGIOGRAPHY (OCTA) PARAMETERS. METHODS: TWENTY-NINE PARTICIPANTS WERE INCLUDED IN THIS MASKED WITHIN PARTICIPANT COMPARISON OF HEALTHY CONTROLS. BASIC OPHTHALMIC EXAMINATION WAS PERFORMED, AFTER WHICH PATIENTS WERE EVALUATED FOR IOP, OCT, AND OCTA BEFORE AND AFTER YOGA EXERCISES FOR EYES. OCT/A PARAMETERS THAT WERE EVALUATED WERE: AVERAGE MACULAR THICKNESS (AMT) (MUM), CENTRAL MACULAR THICKNESS (MUM), CENTRAL CHOROIDAL THICKNESS (MUM) VESSEL DENSITY (%) IN THE SUPERFICIAL, DEEP VASCULAR LAYERS, AND IN THE CHORIOCAPILLARIS. RESULTS: IOP WAS SIGNIFICANTLY REDUCED (POSTEXERCISE IOP = 13.02 MMHG +/- 2.82 MMHG) FROM THE INITIAL VALUE (PREEXERCISE IOP = 13.86 MMHG +/- 2.85 MMHG, P = 0.02). AMT SIGNIFICANTLY INCREASED (POSTEXERCISE AMT = 275.40 MUM +/- 10.85 MUM) FROM THE PREEXERCISE MEASUREMENT (PREEXERCISE AMT = 274.41 MUM +/- 10.89 MUM; P = 0.02). CONCLUSION: AFTER YOGA OCULAR EXERCISES, IOP SIGNIFICANTLY DECREASED AND AMT SIGNIFICANTLY INCREASED IN HEALTHY CONTROLS, SUGGESTING AN EFFECT OF THESE EXERCISES ON THE MACULAR THICKNESS.	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
16 1265  10 FLEXIBILITY-NOT JUST FOR YOGA ANYMORE! OVER THE PAST FEW YEARS, NUCLEOSIDES HAVE MAINTAINED A PROMINENT ROLE AS ONE OF THE CORNERSTONES OF ANTIVIRAL AND ANTICANCER THERAPEUTICS, AND MANY APPROACHES TO NUCLEOSIDE DRUG DESIGN HAVE BEEN PURSUED. ONE SUCH APPROACH INVOLVES FLEXIBILITY IN THE SUGAR MOIETY OF NUCLEOSIDES, FOR EXAMPLE, IN THE HIGHLY SUCCESSFUL ANTI-HIV AND HBV DRUG TENOFOVIR. IN CONTRAST, INTRODUCTION OF FLEXIBILITY TO THE NUCLEOBASE SCAFFOLD HAS ONLY MORE RECENTLY GAINED SIGNIFICANCE WITH THE INVENTION OF OUR FLEXIMERS. THE HISTORY, DEVELOPMENT, AND SOME BIOLOGICAL RELEVANCE FOR THIS INNOVATIVE CLASS OF NUCLEOSIDES ARE DETAILED HEREIN.	2018	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
17 1993  13 STANDARDISATION OF KUTAJADI VISHESH YOGA. AMOEBIASIS IS A PROBLEM IN NORTHERN INDIA. IN AYURVEDA SEVERAL HERBAL DRUGS ARE MENTIONED, TO BE USED FOR CONTROLLING THE AMATISARA (AMOEBIASIS) BUT NONE OF THE DRUG ARE FOUND HAVING POTENT EFFECT TO IRADICATE THE DISEASE. IN ANCIENT LITERATURE KUTAJ (HOLARRHENA ANTIDYSENTRICA) IS MENTIONED IN COMMONEST WAS FOR CONTROLLING THE DISEASE THIS PLANT IS PREVALENTLY FOUND IN HIMALAYAN AND VINDHAYA AREA. IT IS VERY EFFECTIVE FOR RELIEVING AMOEBIASIS. BY SEEING ITS THEURAPTIC IMPORTANCE WE HAVE TRIED TO STANDARDIZE THE COMPOUND IN WHOLE WITH SPECIAL REFERENCE TO KUTAJ. THE DETAIL COMPOSITION AND METHOD OF PREPARATION OF DRUG WITH ITS THERAPEUTIC EFFECT WILL BE NARRATED DURING THE TIME OF WORKSHOP.	1998	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
18 1264  15 FLEXIBILITY, FUNCTIONAL AUTONOMY AND QUALITY OF LIFE (QOL) IN ELDERLY YOGA PRACTITIONERS. THE AIM OF THIS STUDY WAS TO ASSESS THE LEVELS OF FLEXIBILITY, FUNCTIONAL AUTONOMY AND QOL IN ELDERLY YOGA PRACTITIONERS. THE SUBJECTS WERE DIVIDED INTO A YOGA GROUP (YG; N = 52; AGE = 66.79 +/- 3.30 YEARS; BMI = 24.77 +/- 3.18) AND CONTROL GROUP (CG; N = 31; AGE = 69.33 +/- 4.84 YEARS; BMI = 24.32 +/- 3.71) AND SUBMITTED TO FLEXIBILITY TESTS THROUGH GONIOMETRY, THE LADEG AUTONOMY PROTOCOL AND QOL, USING THE WHOQOL-OLD QUESTIONNAIRE. REPEATED MEASURES ANOVA SHOWED INCREASES IN ARTICULAR RANGE OF MOTION IN SHOULDER ABDUCTION (DELTA%SA = 14.11%; P = 0.0001), HORIZONTAL SHOULDER EXTENSION (DELTA%HSE = 33.90%; P = 0.0001), LUMBAR SPINE FLEXION (DELTA%LSF = 50.74%; P = 0.0001), HIP FLEXION (DELTA%HF = 35.75%; P = 0.0001), HIP EXTENSION (DELTA%HE = 10.93%; P = 0.021) AND KNEE FLEXION (DELTA%KF = 3.90%; P = 0.001) AND IN THE GDLAM AUTONOMY INDEX (DELTA%AI = -13.67%; P = 0.0001) IN THE YG COMPARED TO THE CG. THE MANN-WHITNEY TEST REVEALED INCREASES IN QOL SCORES IN FACET 1 (DELTA%FAC1 = 9.04%; P=0.043), FACET 5 (DELTA%FAC5 = 51.06%; P = 0.0001) AND IN OVERALL QOL (DELTA%OQOL = 8.13%; P = 0.046) IN THE YG COMPARED TO THE CG. THE REMAINING VARIABLES SHOWED NO SIGNIFICANT INTERGROUP MODIFICATIONS. THUS, THE STUDY SUGGESTS THAT THE REGULAR PRACTICE OF YOGA MAY LEAD TO IMPROVED RANGE OF MOTION IN THE PERFORMANCE OF ACTIVITIES OF DAILY LIVING IN ELDERLY WOMEN.	2011	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
19   32  26 5-HTTLPR AND MTHFR 677C>T POLYMORPHISMS AND RESPONSE TO YOGA-BASED LIFESTYLE INTERVENTION IN MAJOR DEPRESSIVE DISORDER: A RANDOMIZED ACTIVE-CONTROLLED TRIAL. BACKGROUND: THERE IS GROWING EVIDENCE SUGGESTING THAT BOTH GENETIC AND ENVIRONMENTAL FACTORS MODULATE TREATMENT OUTCOME IN, A HIGHLY HETEROGENEOUS, MAJOR DEPRESSIVE DISORDER (MDD). 5-HTTLPR VARIANT OF THE SEROTONIN TRANSPORTER GENE (SLC6A4) AND MTHFR 677C>T POLYMORPHISMS HAVE BEEN LINKED TO THE PATHOGENESIS OF MDD, AND ANTIDEPRESSANT TREATMENT RESPONSE. THE EVIDENCE IS LACKING ON THE CLINICAL UTILITY OF YOGA IN PATIENTS WITH MDD WHO HAVE 5-HTTLPR AND MTHFR 677C>T POLYMORPHISMS AND LESS LIKELY TO RESPOND TO MEDICATIONS (SSRIS). AIMS: WE AIMED TO EXAMINE THE IMPACT OF YBLI IN THOSE WHO HAVE SUSCEPTIBLE 5-HTTLPR AND MTHFR 677C>T POLYMORPHISMS AND ARE LESS LIKELY TO DRUG THERAPY WITH SSRIS. SETTINGS AND DESIGN: IN A 12 WEEK RANDOMIZED ACTIVE-CONTROLLED TRIAL, MDD PATIENTS (N = 178) WERE RANDOMIZED TO RECEIVE YBLI OR DRUG THERAPY. METHODS: GENOTYPING WAS CONDUCTED USING PCR-BASED METHODS. THE CLINICAL REMISSION WAS DEFINED AS BDI-II SCORE </= 9. STATISTICAL ANALYSIS USED: AN INTENT-TO-TREAT ANALYSIS WAS PERFORMED, AND THE ASSOCIATION OF GENOTYPE WITH TREATMENT REMISSION CONSISTED OF THE LOGISTIC REGRESSION MODEL. A P VALUE OF <0.05 WAS CONSIDERED STATISTICALLY SIGNIFICANT. RESULTS: MULTIVARIATE LOGISTIC REGRESSION MODELS FOR REMISSION INCLUDING EITHER 5-HTTLPR OR MTHFR 677C>T GENOTYPES SHOWED STATISTICALLY SIGNIFICANT ODDS OF REMISSION IN YOGA ARM VS. DRUG ARM. NEITHER 5-HTTLPR NOR MTHFR 677C>T GENOTYPE SHOWED ANY INFLUENCE ON REMISSION TO YBLI (P = 0.73 AND P = 0.64, RESPECTIVELY). FURTHER ANALYSIS SHOWED CHILDHOOD ADVERSITY INTERACT WITH 5-HTTLPR AND MTHFR 677C>T POLYMORPHISMS TO DECREASE TREATMENT RESPONSE IN DRUG TREATMENT ARM, BUT NOT IN YOGA ARM. CONCLUSIONS: YBLI PROVIDES MDD REMISSION IN THOSE WHO HAVE SUSCEPTIBLE 5-HTTLPR AND MTHFR 677C>T POLYMORPHISMS AND ARE RESISTANT TO SSRIS TREATMENT. YBLI MAY BE THERAPEUTIC FOR MDD INDEPENDENT OF HETEROGENEITY IN ITS ETIOPATHOGENESIS.	2018	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
20 2164  18 THE EFFECTS OF YOGA AND SELF-ESTEEM ON MENOPAUSAL SYMPTOMS AND QUALITY OF LIFE IN BREAST CANCER SURVIVORS-A SECONDARY ANALYSIS OF A RANDOMIZED CONTROLLED TRIAL. OBJECTIVES: PREVIOUS RESEARCH HAS FOUND THAT YOGA CAN ENHANCE QUALITY OF LIFE AND EASE MENOPAUSAL SYMPTOMS OF BREAST CANCER SURVIVORS. THE STUDY EXAMINED WHETHER SELF-ESTEEM MEDIATED THE EFFECTS OF YOGA ON QUALITY OF LIFE, FATIGUE AND MENOPAUSAL SYMPTOMS, UTILIZING VALIDATED OUTCOME MEASURES. STUDY DESIGN: THIS IS A SECONDARY ANALYSIS OF A RANDOMIZED CONTROLLED TRIAL COMPARING THE EFFECTS OF YOGA WITH THOSE OF USUAL CARE IN 40 BREAST CANCER SURVIVORS WHO SUFFERED FROM MENOPAUSAL SYMPTOMS. ALL PARTICIPANTS COMPLETED ALL 3 ASSESSMENTS (WEEK 0, WEEK 12, AND WEEK 24) AND PROVIDED FULL DATA. MAIN OUTCOME MEASURES: OUTCOMES WERE MEASURED USING SELF-RATING INSTRUMENTS. MEDIATION ANALYSES WERE PERFORMED USING SPSS. RESULTS: SELF-ESTEEM MEDIATED THE EFFECT OF YOGA ON TOTAL MENOPAUSAL SYMPTOMS (B=-2.11, 95% BCI [-5.40 TO -0.37]), PSYCHOLOGICAL MENOPAUSAL SYMPTOMS (B=-0.94, 95% BCI [-2.30 TO -0.01]), AND UROGENITAL MENOPAUSAL SYMPTOMS (B=-0.66, 95% BCI [-1.65 TO -0.15]), QUALITY OF LIFE (B=8.04, 95% BCI [3.15-17.03]), SOCIAL WELL-BEING (B=1.80, 95% BCI [0.54-4.21]), EMOTIONAL WELL-BEING (B=1.62, 95% BCI [0.70-3.34]), FUNCTIONAL WELL-BEING (B=1.84, 95% BCI [0.59-4.13]), AND FATIGUE (B=4.34, 95% BCI [1.28-9.55]). SELF-ESTEEM HAD NO EFFECT ON SOMATOVEGETATIVE MENOPAUSAL SYMPTOMS (B=-0.50, 95% BCI N.S.) OR ON PHYSICAL WELL-BEING (B=0.79, 95% BCI N.S.). CONCLUSIONS: FINDINGS SUPPORT THE ASSUMPTION THAT SELF-ESTEEM PLAYS A VITAL ROLE IN THE BENEFICIAL EFFECT OF YOGA AND THAT YOGA CAN HAVE LONG-TERM BENEFITS FOR WOMEN DIAGNOSED WITH BREAST CANCER AND UNDERGOING MENOPAUSAL TRANSITION.	2017