1 1389 162 IMPACT OF SOMATIC YOGA AND MEDITATION ON FALL RISK, FUNCTION, AND QUALITY OF LIFE FOR CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY SYNDROME IN CANCER SURVIVORS. OBJECTIVE: CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY (CIPN) SYNDROME CAUSES SIGNIFICANT PAIN AS AN ADVERSE EFFECT OF TREATMENT, WITH FEW NONPHARMACOLOGICAL INTERVENTIONS TESTED. A SOMATIC YOGA AND MEDITATION (SYM) INTERVENTION ON FUNCTIONAL OUTCOMES AND QUALITY OF LIFE (QOL) WAS INVESTIGATED. DESIGN AND METHODS: INDIVIDUALS DIAGNOSED WITH CIPN WERE ENROLLED IN AN OPEN-LABEL, SINGLE-ARM, MIXED-METHODS FEASIBILITY TRIAL. PARTICIPANTS AND SETTING: IN AN OUTPATIENT REHABILITATION CENTER, TEN PARTICIPANTS WITH MEDIAN AGE 64.4 YEARS (47-81) ATTENDED 61% OF THE SESSIONS WITH NO ADVERSE EVENTS. INTERVENTION: SYM TWICE A WEEK FOR 8 WEEKS FOR 1.5 HOURS, WITH HOME PROGRAM AND JOURNALING. MAIN OUTCOME MEASURES: PRIMARY FUNCTIONAL OUTCOMES INCLUDED SIT AND REACH (SR), FUNCTIONAL REACH (FR), AND TIMED UP AND GO (TUG). SELF-REPORTED PATIENT NEUROTOXICITY QUESTIONNAIRE (PNQ) AND FUNCTIONAL ASSESSMENT OF CANCER THERAPY-NEUROTOXICITY (FACT-GOG-NTX) WERE SECONDARY CIPN OUTCOMES. BIOMARKERS INCLUDED SALIVARY CORTISOL (STRESS) AND BIOESTHESIOMETER (VIBRATION). RESULTS: QUANTITATIVE FINDINGS. SIGNIFICANT IMPROVEMENTS WERE FOUND IN FLEXIBILITY (SR; P = .006); BALANCE (FR; P = .001) AND FALL RISK (TUG; P = .004). PNQ IMPROVED SIGNIFICANTLY ( P = .003) WITH OTHER MEASURES IMPROVING NON-SIGNIFICANTLY. QUALITATIVE FINDINGS. FIVE THEMES EMERGED: (1) VACILLATION OF CIPN PAIN PERCEPTION OVER TIME; (2) TRANSFERABILITY OF SKILLS TO DAILY ACTIVITIES; (3) IMPROVEMENT IN PHYSICAL FUNCTION; (4) PERCEIVED RELAXATION AS AN EFFECT OF SYM; AND (5) GROUP ENGAGEMENT PROVIDED A SOCIAL CONTEXT FOR NOT FEELING ISOLATED WITH CIPN. CONCLUSION: PRELIMINARY DATA SUGGEST SYM MAY IMPROVE QOL, FLEXIBILITY, AND BALANCE IN CANCER SURVIVORS WITH CIPN, WITH A FULLY POWERED RANDOMIZED CONTROLLED TRIAL INDICATED. TRIAL REGISTRATION: NCT03786055.	2019	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
2  916  87 EFFECTIVENESS OF SOMATIC YOGA AND MEDITATION: A PILOT STUDY IN A MULTICULTURAL CANCER SURVIVOR POPULATION WITH CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY. CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY (CIPN) CAUSES SIGNIFICANT PAIN AND IS AN ADVERSE EFFECT OF TREATMENT WITH CHEMOTHERAPEUTIC AGENTS. WE EXPLORED A SOMATIC YOGA AND MEDITATION INTERVENTION IN A PREDOMINANTLY MINORITY POPULATION. GOALS INCLUDED DESCRIBING STRATEGIES FOR MINORITY INCLUSION AND TESTING FEASIBILITY AND EFFECTIVENESS. EIGHT INDIVIDUALS WITH CIPN ENROLLED IN A SINGLE-ARM FEASIBILITY TRIAL. SOMATIC YOGA AND MEDITATION WERE PROVIDED WEEKLY FOR 8 WEEKS, WITH AN ADDITIONAL HOME PROGRAM COMPONENT. THE PRIMARY OUTCOMES WERE SIT AND REACH, FUNCTIONAL REACH, AND TIMED UP AND GO. SECONDARY OUTCOMES WERE PATIENT NEUROTOXICITY QUESTIONNAIRE, FACT-GOG-NTX (FOR ADDRESSING PATIENT CONCERNS ASSOCIATED WITH NEUROLOGICAL SYMPTOMS), BRIEF PAIN INVENTORY, PERCEIVED STRESS SCALE, PITTSBURGH SLEEP QUALITY INDEX, AND FALLS EFFICACY SCALE. SENSITIVITY TO VIBRATION WAS MEASURED VIA BIOTHESIOMETER. PARTICIPANTS WITH A MEAN AGE OF 65 (49-73) YEARS SELF-REPORTED AS 63% AFRICAN-AMERICAN AND 37% CAUCASIAN. THEY ATTENDED 81% OF THE SESSIONS, AND NO ADVERSE EVENTS WE RE RE P O RTED. CIPN SYMPTOMS (FAC T- G O G - N T X ) IMPROVED SIGNIFICANTLY (FROM 88.88 TO 106.88, STANDARD DEVIATION = 20.03; P = 0.039). FEAR OF FALLING IMPROVED, APPROACHING SIGNIFICANCE (FROM 39.26 TO 34.38, STANDARD DEVIATION = 6.081; P = 0.058). OTHER MEASURES SHOWED IMPROVEMENT TRENDS, WITH A SLIGHT INCREASE IN BRIEF PAIN INVENTORY PAIN SEVERITY (FROM 3.50 TO 3.75, P = 0.041) POSSIBLY REFLECTING COMORBIDITIES. FOUR QUALITATIVE THEMES EMERGED: (1) CIPN SYMPTOM VARIABILITY, WITH MUSCULOSKELETAL COMORBIDITIES; (2) UTILITY OF LEARNED SKILLS; (3) IMPROVEMENT IN SELF-CONFIDENCE, BALANCE, AND STABILITY; AND (4) SOCIAL SUPPORT, WITH CIPN EXPERIENCE VALIDATION AND INCREASING HEALTH LITERACY. CHALLENGES OF RECRUITMENT AND RETENTION REQUIRE SPECIFIC OUTREACH, COMMUNITY TRUST, AND HEALTH LITERACY. PRELIMINARY DATA SUGGEST THAT SOMATIC YOGA AND MEDITATION MAY AFFECT FEAR OF FALLING AND QUALITY OF LIFE IN CANCER SURVIVORS WITH CIPN. A RANDOMIZED CONTROLLED TRIAL USING INCLUSIVE RECRUITMENT AND RETENTION METHODS IS INDICATED TO ESTABLISH THE INTERVENTION'S EFFICACY.	2020	
                                                                                                                                                                                                                                                                                                                                                                     
3 2557  47 YOGA FOR CHRONIC CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY PAIN: A PILOT, RANDOMIZED CONTROLLED TRIAL. PURPOSE: TO DETERMINE THE FEASIBILITY OF IMPLEMENTING A YOGA INTERVENTION FOR CANCER SURVIVORS WITH CHRONIC CIPN PAIN, AS WELL AS THE IMPACT OF THE INTERVENTION ON PATIENT-REPORTED OUTCOMES. METHODS: CANCER SURVIVORS WITH CHRONIC CIPN PAIN WERE RECRUITED FROM THE BREAST, GASTROINTESTINAL, AND GYNECOLOGICAL ONCOLOGY CENTERS AT DANA-FARBER CANCER INSTITUTE. PARTICIPANTS WERE RANDOMIZED (2:1) TO RECEIVE AN 8-WEEK YOGA INTERVENTION OR USUAL CARE. AFTER 21/50 OF PARTICIPANTS WERE ENROLLED, THE COVID-19 PANDEMIC REQUIRED THE YOGA INTERVENTION TO BE DELIVERED VIRTUALLY (I.E., ZOOM). PRE- AND POST-INTERVENTION, PARTICIPANTS SELF-REPORTED CIPN AND CO-OCCURRING SYMPTOM SEVERITY. ADHERENCE TO THE INTERVENTION WAS DEFINED AS PRACTICING >/= 12 YOGA SESSIONS OVER THE 8-WEEK INTERVENTION PERIOD. CHANGES IN PATIENT-REPORTED OUTCOMES BETWEEN GROUPS WERE COMPARED USING WILCOXON'S RANK-SUM TESTS. RESULTS: PARTICIPANTS (N = 28 YOGA, N = 16 CONTROL) WERE MAINLY FEMALE (96%) AND DIAGNOSED WITH STAGE III/IV DISEASE (66%). OVERALL, 19/28 (67.8%) OF YOGA GROUP PARTICIPANTS WERE ADHERENT TO THE YOGA PROTOCOL. YOGA GROUP PARTICIPANTS EXPERIENCED SIGNIFICANT WITHIN-GROUP IMPROVEMENTS IN ALL PATIENT-REPORTED OUTCOMES, INCLUDING WORST CIPN PAIN (MEDIAN CHANGE = - 1.7, P < 0.0001) AND SENSORY CIPN (MEDIAN CHANGE = - 14.8, P < 0.0001), BUT ONLY IMPROVEMENTS IN FATIGUE (P = 0.05) AND DEPRESSION (P = 0.04) WERE SIGNIFICANT COMPARED TO THE CONTROL. THERE WERE NO DIFFERENCES (P > 0.05) IN CHANGES IN PATIENT-REPORTED OUTCOMES BETWEEN IN-PERSON (N = 6) OR VIRTUAL (N = 15) YOGA GROUP PARTICIPANTS. CONCLUSIONS: YOGA IS A FEASIBLE NON-PHARMACOLOGICAL MODALITY FOR CANCER SURVIVORS WITH CIPN, BUT MORE INFORMATION IS NEEDED REGARDING ITS IMPACT ON CIPN AND OTHER SYMPTOMS. TRIAL REGISTRATION: CLINICALTRIALS.GOV IDENTIFIER: NCT03824860 IMPLICATIONS FOR CANCER SURVIVORS: ONCOLOGY CLINICIANS MAY CONSIDER REFERRING CANCER SURVIVORS TO YOGA FOR CHRONIC CIPN PAIN, BUT YOGA CANNOT BE CURRENTLY RECOMMENDED AS AN EFFICACIOUS TREATMENT.	2021	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
4 2549  42 YOGA FOR CANCER SURVIVORS WITH CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY: HEALTH-RELATED QUALITY OF LIFE OUTCOMES. BACKGROUND: YOGA IS A MEDITATIVE MOVEMENT THERAPY FOCUSED ON MIND-BODY AWARENESS. THE IMPACT OF YOGA ON HEALTH-RELATED QUALITY OF LIFE (HRQOL) OUTCOMES IN PATIENTS WITH CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY (CIPN) IS UNCLEAR. METHODS: WE CONDUCTED A PILOT RANDOMIZED WAIT-LIST CONTROLLED TRIAL OF 8 WEEKS OF YOGA (N = 21) VERSUS WAIT-LIST CONTROL (N = 20) FOR CIPN IN 41 BREAST AND GYNECOLOGICAL CANCER SURVIVORS WITH PERSISTENT MODERATE TO SEVERE CIPN. HRQOL ENDPOINTS WERE HOSPITAL ANXIETY AND DEPRESSION SCALE (HADS), BRIEF FATIGUE INVENTORY (BFI), AND INSOMNIA SEVERITY INDEX (ISI). THE TREATMENT EXPECTANCY SCALE (TES) WAS ADMINISTERED AT BASELINE. WE ESTIMATED MEAN CHANGES AND 95% CONFIDENCE INTERVALS (CIS) FROM BASELINE TO WEEKS 8 AND 12 AND COMPARED ARMS USING CONSTRAINED LINEAR MIXED MODELS. RESULTS: AT WEEK 8, HADS ANXIETY SCORES DECREASED -1.61 (-2.75, -0.46) IN THE YOGA ARM AND -0.32 (-1.38, 0.75) POINTS IN THE WAIT-LIST CONTROL ARM (P = 0.099). AT WEEK 12, HADS ANXIETY SCORES DECREASED -1.42 (-2.57, -0.28) IN YOGA COMPARED TO AN INCREASE OF 0.46 (-0.60, 1.53) IN WAIT-LIST CONTROL (P = 0.017). THERE WERE NO SIGNIFICANT DIFFERENCES IN HADS DEPRESSION, BFI, OR ISI SCORES BETWEEN YOGA AND WAIT-LIST CONTROL. BASELINE TES WAS SIGNIFICANTLY HIGHER IN YOGA THAN IN WAIT-LIST CONTROL (14.9 VS. 12.7, P = 0.019). TES WAS NOT ASSOCIATED WITH HADS ANXIETY REDUCTION AND HADS ANXIETY REDUCTION WAS NOT ASSOCIATED WITH CIPN PAIN REDUCTION. CONCLUSIONS: YOGA MAY REDUCE ANXIETY IN PATIENTS WITH CIPN. FUTURE STUDIES ARE NEEDED TO CONFIRM THESE FINDINGS. CLINICAL TRIAL REGISTRATION NUMBER: CLINICALTRIALS.GOV IDENTIFIER: NCT03292328.	2021	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
5 1232  43 FEASIBILITY AND POTENTIAL BENEFITS OF PARTNER-SUPPORTED YOGA ON PSYCHOSOCIAL AND PHYSICAL FUNCTION AMONG LUNG CANCER PATIENTS. OBJECTIVE: PATIENTS WITH LUNG CANCER EXPERIENCE SIGNIFICANT DECLINES IN PSYCHOSOCIAL AND PHYSICAL FUNCTION DURING AND AFTER TREATMENT THAT IMPACT QUALITY OF LIFE (QOL) AND SURVIVAL. YOGA IS A POTENTIAL STRATEGY TO MITIGATE FUNCTIONAL DECLINE AMONG PATIENTS WITH LUNG CANCER. METHODS: A SINGLE GROUP 12-WEEK PILOT TRIAL OF LOW-MODERATE INTENSITY YOGA AMONG PATIENTS WITH STAGE I-IV LUNG CANCER AND THEIR PARTNERS (N = 46; 23 PATIENT-PARTNER DYADS) DURING CANCER TREATMENT FROM TWO HOSPITAL SYSTEMS. FEASIBILITY, ACCEPTABILITY, DESCRIPTIVE STATISTICS, AND COHEN D EFFECT SIZES WERE CALCULATED AT 6 AND 12-WEEKS FOR PSYCHOSOCIAL AND PHYSICAL OUTCOMES USING VALIDATED QUESTIONNAIRES AND ASSESSMENTS. RESULTS: AT 6 AND 12-WEEKS, RETENTION WAS 65% AND WITHDRAWALS WERE MAINLY DUE TO DISEASE PROGRESSION. AMONG STUDY COMPLETERS (N = 26; 13 DYADS) ADHERENCE WAS 80%. COMPARING BASELINE TO 12-WEEK MEASUREMENTS, FATIGUE, DEPRESSION SYMPTOMS, AND SLEEP DISTURBANCE IMPROVED IN 54% OF PARTICIPANTS FOR ALL THREE MEASURES (COHEN'S D = 0.40-0.53). QOL IMPROVED IN 77% OF PARTICIPANTS (COHEN'S D = 0.34). UPPER AND LOWER BODY FLEXIBILITY, AND LOWER BODY STRENGTH IMPROVED IN 92%, 85% AND 77% OF PARTICIPANTS, RESPECTIVELY (COHEN'S D = 0.39-1.08). SIX-MINUTE WALK TEST IMPROVED IN 62% OF PARTICIPANTS AN AVERAGE OF 32 METERS (SD = 11.3; COHEN'S D = 0.17). NO SERIOUS ADVERSE EVENTS WERE REPORTED. CONCLUSIONS: AMONG PATIENTS WITH STAGE I-IV LUNG CANCER INCLUDING ACTIVE TREATMENT, A 12-WEEK PARTNER-SUPPORTED YOGA PROGRAM IS FEASIBLE, ACCEPTABLE, AND IMPROVED PSYCHOSOCIAL AND PHYSICAL FUNCTION. LOW-INTENSITY YOGA MAY BE A COMPLIMENTARY APPROACH TO REDUCE THE EFFECTS OF CANCER TREATMENT, HOWEVER, MORE RESEARCH IS NEEDED TO DETERMINE THE EFFICACY OF PARTNER-SUPPORTED YOGA TO MITIGATE FUNCTIONAL DECLINE.	2021	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
6 1564  66 LONGITUDINAL IMPACT OF YOGA ON CHEMOTHERAPY-RELATED COGNITIVE IMPAIRMENT AND QUALITY OF LIFE IN WOMEN WITH EARLY STAGE BREAST CANCER: A CASE SERIES. PURPOSE: ADJUVANT CHEMOTHERAPY FOR WOMEN WITH BREAST CANCER HAS SIGNIFICANTLY IMPROVED THE CURE RATE; HOWEVER, IT HAS BEEN ASSOCIATED WITH CHEMOTHERAPY-RELATED COGNITIVE IMPACT (CRCI). THE LITERATURE PROVIDES PRELIMINARY SUPPORT FOR THE FEASIBILITY AND EFFICACY OF YOGA INTERVENTIONS FOR THE GENERAL CANCER POPULATION, HOWEVER, CONTROLLED TRIALS ARE SCARCE AND NO STUDIES HAVE EXAMINED THE EFFECT OF YOGA ON COGNITION FOR WOMEN WITH BREAST CANCER DURING CHEMOTHERAPY. THIS CASE SERIES AIMS TO IDENTIFY THE IMPACT OF YOGA ON MEASURES OF COGNITION, FUNCTIONAL OUTCOMES, AND QUALITY OF LIFE (QOL) FOR BREAST CANCER SURVIVORS (BCS). METHODS: FOUR WOMEN WITH A DIAGNOSIS OF EARLY-STAGE BREAST CANCER PRIOR TO CHEMOTHERAPY TREATMENT WERE ADMINISTERED THE FOLLOWING PHYSIOLOGIC MEASURES AT BASELINE, 6, AND 12 WEEKS DURING CHEMOTHERAPY, AND AT ONE AND THREE MONTHS AFTER THE CONCLUSION OF THE STUDY: FUNCTIONAL REACH TEST (BALANCE) AND SIT AND REACH TEST (FLEXIBILITY), AND QOL, POMS (MOOD) AND FACT-B (QOL), AT BASELINE. PRIMARY OUTCOMES OF COGNITION WERE MEASURED WITH THE PERCEIVED COGNITION QUESTIONNAIRE (PCQ) AND COGSTATE, A COMPUTERIZED MEASUREMENT OF COGNITION. WOMEN ATTENDED AN IYENGAR-INSPIRED YOGA PROGRAM TWICE A WEEK FOR 12 WEEKS. QUALITATIVE QUESTIONNAIRES WERE ADMINISTERED AFTER THE COMPLETION OF THE STUDY TO DETERMINE PERCEIVED BENEFITS AND CHALLENGES OF THE YOGA PROGRAM. RESULTS: FOUR WOMEN WITH STAGE II BREAST CANCER RANGED IN AGE FROM 44-65 YEARS. COGSTATE COMPUTERIZED TESTING SHOWED CHANGES IN VARYING DOMAINS OF COGNITION THROUGH TREATMENT AND FOLLOW-UP. IMPROVED BALANCE, FLEXIBILITY, AND QOL WERE ALSO NOTED OVER TIME. NO ADVERSE EVENTS WERE OBSERVED. ANALYSIS OF QUALITATIVE DATA REVEALED THE YOGA CLASSES WERE HELPFUL AND SUBJECTS CONTINUED THE PRACTICE ELEMENTS OF YOGA INCLUDING RELAXATION, BREATHING, AND STRETCHING. THE MOST CHALLENGING ASPECT OF THE STUDY WAS PHYSICAL LIMITATIONS DUE TO VARIOUS MEDICAL COMPLICATIONS AND INCLUDED FATIGUE, DECREASED RANGE OF MOTION, AND PAIN. CONCLUSION: THIS CASE SERIES SUGGESTS THAT YOGA MAY IMPACT VARIOUS ASPECTS OF COGNITION DURING AND AFTER CHEMOTHERAPY ADMINISTRATION AS NOTED THROUGH QUANTITATIVE MEASURES. WOMEN DESCRIBE YOGA AS IMPROVING VARIOUS DOMAINS OF QOL THROUGH THE TREATMENT TRAJECTORY. THIS MIND-BODY INTERVENTION MAY STAVE OFF CRCI; HOWEVER, FURTHER INVESTIGATION IS NEEDED FOR ADDITIONAL RANDOMIZED CONTROLLED TRIALS ON THE EFFECTS OF YOGA ON COGNITION FOR WOMEN WITH BREAST CANCER UNDERGOING ADJUVANT CHEMOTHERAPY TREATMENT.	2012	

7  206  30 A SELF-DIRECTED HOME YOGA PROGRAMME FOR WOMEN WITH BREAST CANCER DURING CHEMOTHERAPY: A FEASIBILITY STUDY. RECENT STUDIES SUGGEST YOGA AS A PROMISING APPROACH FOR IMPROVING THE COGNITIVE FUNCTION OF CANCER SURVIVORS. WE STUDIED WHETHER A SELF-DIRECTED HOME YOGA PROGRAMME WAS FEASIBLE FOR PATIENTS WITH BREAST CANCER WHO WERE UNDERGOING CHEMOTHERAPY. PARTICIPANTS' PREFERENCES FOR THE TYPE OF YOGA COURSE AND THE CLINICAL EFFECTS OF THE PROGRAMME WERE ALSO ASSESSED. IN THIS STUDY, 18 WOMEN (MEAN AGE, 43.9 YEARS) WERE ENROLLED (44.7% RECRUITMENT RATE). OF THE PARTICIPANTS, 63.6% HAD STAGE II CANCER AND 71.4% RECEIVED ADJUVANT CHEMOTHERAPY. FAVOURABLE RETENTION (86%), ADHERENCE (94.4%) AND ACCEPTABILITY (96.5%) RATES WERE DETERMINED. MOST (94.4%) OF THE WOMEN PRACTICED THE HOME PROGRAMME MORE THAN TWICE A WEEK ON AVERAGE. THE PARTICIPANTS PREFERRED TO GRADUALLY INCREASE THE INTENSITY OF THE EXERCISES. WE ONLY OBSERVED IMPROVEMENTS IN THE COGNITIVE ASPECTS OF FATIGUE. NO SERIOUS ADVERSE EVENTS WERE ENCOUNTERED DURING THE PROGRAMME. THIS SELF-DIRECTED HOME YOGA PROGRAMME WAS SAFE AND FEASIBLE FOR PATIENTS WITH BREAST CANCER UNDERGOING CHEMOTHERAPY.	2016	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
8 1242  47 FEASIBILITY OF A YOGA INTERVENTION TO DECREASE PAIN IN OLDER WOMEN: A RANDOMIZED CONTROLLED PILOT STUDY. BACKGROUND: A SIGNIFICANT PROPORTION OF OLDER WOMEN SUFFER FROM CHRONIC PAIN, WHICH CAN DECREASE QUALITY OF LIFE. THE OBJECTIVE OF THIS PILOT RANDOMIZED STUDY WAS TO EVALUATE THE FEASIBILITY OF A FLOW-RESTORATIVE YOGA INTERVENTION DESIGNED TO DECREASE PAIN AND RELATED OUTCOMES AMONG WOMEN AGED 60 OR OLDER. METHODS: FLOW-RESTORATIVE YOGA CLASSES WERE HELD TWICE WEEKLY FOR 1 HOUR AND LED BY A CERTIFIED YOGA INSTRUCTOR. PARTICIPANTS RANDOMIZED TO THE INTERVENTION GROUP ATTENDED THE YOGA CLASSES FOR 12 WEEKS AND RECEIVED SUPPLEMENTAL MATERIALS FOR AT-HOME PRACTICE. THOSE RANDOMIZED TO THE CONTROL GROUP WERE ASKED TO MAINTAIN THEIR NORMAL DAILY ROUTINE. FEASIBILITY WAS EVALUATED USING RECRUITMENT AND RETENTION RATES, CLASS AND HOME PRACTICE ADHERENCE RATES, AND PARTICIPANT SATISFACTION SURVEYS. OUTCOME MEASURES (SELF-REPORTED PAIN, INFLAMMATORY MARKERS, FUNCTIONAL FITNESS, QUALITY OF LIFE, RESILIENCE, AND SELF-REPORTED PHYSICAL ACTIVITY) WERE ASSESSED AT BASELINE AND POST-INTERVENTION. PAIRED T-TESTS OR WILCOXON SIGNED-RANK TESTS WERE USED TO EXAMINE CHANGES IN OUTCOME MEASURES WITHIN TREATMENT GROUPS. RESULTS: THIRTY-EIGHT PARTICIPANTS WERE RECRUITED AND RANDOMIZED. PARTICIPANTS WERE PRIMARILY WHITE, COLLEGE-EDUCATED, AND HIGHER FUNCTIONING, DESPITE EXPERIENCING VARIOUS FORMS OF CHRONIC PAIN. ATTENDANCE AND RETENTION RATES WERE HIGH (91 AND 97%, RESPECTIVELY) AND THE MAJORITY OF PARTICIPANTS WERE SATISFIED WITH THE YOGA PROGRAM (89%) AND WOULD RECOMMEND IT TO OTHERS (87%). INTERVENTION PARTICIPANTS ALSO EXPERIENCED REDUCTIONS IN PAIN INTERFERENCE AND IMPROVEMENTS IN ENERGY AND SOCIAL FUNCTIONING. CONCLUSIONS: THIS PILOT STUDY PROVIDES ESSENTIAL DATA TO INFORM A FULL SCALE RANDOMIZED TRIAL OF FLOW-RESTORATIVE YOGA FOR OLDER WOMEN WITH CHRONIC PAIN. FUTURE STUDIES SHOULD EMPHASIZE STRATEGIES TO RECRUIT A MORE DIVERSE STUDY POPULATION, PARTICULARLY OLDER WOMEN AT HIGHER RISK OF DISABILITY AND FUNCTIONAL DECLINE. TRIAL REGISTRATION: CLINICALTRIALS.GOV , NCT03790098 . REGISTERED 31 DECEMBER 2018 - RETROSPECTIVELY REGISTERED.	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
9 1245  42 FEASIBILITY OF IMPLEMENTING A COMMUNITY-BASED RANDOMIZED TRIAL OF YOGA FOR WOMEN UNDERGOING CHEMOTHERAPY FOR BREAST CANCER. BACKGROUND: TREATMENT-RELATED SYMPTOMS AND DECREASED HEALTH-RELATED QUALITY OF LIFE (HRQOL) FREQUENTLY OCCUR DURING CHEMOTHERAPY FOR BREAST CANCER. ALTHOUGH RESEARCH FINDINGS SUGGEST THAT YOGA CAN REDUCE SYMPTOMS AND IMPROVE HRQOL AFTER TREATMENT, POTENTIAL BENEFITS OF YOGA DURING CHEMOTHERAPY HAVE RECEIVED MINIMAL ATTENTION. OBJECTIVE: TO ESTIMATE ACCRUAL, ADHERENCE, STUDY RETENTION, AND PRELIMINARY EFFICACY OF A YOGA INTERVENTION COMPARED WITH AN ACTIVE CONTROL GROUP FOR BREAST CANCER PATIENTS DURING CHEMOTHERAPY. METHODS: WOMEN WITH STAGE I-III BREAST CANCER WERE RECRUITED FROM 3 COMMUNITY CANCER CLINICS AND RANDOMIZED TO 10 WEEKS OF GENTLE YOGA OR WELLNESS EDUCATION. DEPRESSIVE SYMPTOMS, FATIGUE, SLEEP, AND HRQOL WERE ASSESSED AT BASELINE, MID-INTERVENTION (WEEK 5), AND AFTER INTERVENTION (WEEK 10). RESULTS: 40 WOMEN AGED 29-83 YEARS (MEDIAN, 48 YEARS; 88% WHITE) WERE RANDOMIZED TO YOGA (N = 22) OR WELLNESS EDUCATION (N = 18). THE GROUPS DID NOT DIFFER SIGNIFICANTLY ON BASELINE CHARACTERISTICS, ADHERENCE, OR STUDY RETENTION. PARTICIPANT FEEDBACK WAS POSITIVE AND COMPARABLE BETWEEN GROUPS. MEANINGFUL WITHIN-GROUP DIFFERENCES WERE IDENTIFIED FOR SLEEP ADEQUACY AND QUANTITY IN YOGA PARTICIPANTS AND FOR SOMNOLENCE IN WELLNESS-EDUCATION PARTICIPANTS. LIMITATIONS: SMALL SAMPLE SIZE AND LACK OF A USUAL-CARE CONTROL GROUP. CONCLUSIONS: THIS STUDY ESTABLISHED FEASIBILITY OF A COMMUNITY-BASED RANDOMIZED TRIAL OF YOGA AND AN ACTIVE COMPARISON GROUP FOR WOMEN UNDERGOING CHEMOTHERAPY FOR BREAST CANCER. PRELIMINARY EFFICACY ESTIMATES SUGGEST THAT YOGA IMPROVES SLEEP ADEQUACY SYMPTOM SEVERITY AND INTERFERENCE REMAINED STABLE DURING CHEMOTHERAPY FOR THE YOGA GROUP AND SNOWED A TREND TOWARD INCREASING IN THE CONTROL GROUP. THE STUDY HIGHLIGHTED OBSTACLES TO MULTISITE YOGA RESEARCH DURING CANCER TREATMENT. FUNDING/SPONSORSHIP: NATIONAL CANCER INSTITUTE (3U10 CA081851, PI; SHAW; R25 CA122061, PI: AVIS); TRANSLATIONAL SCIENCE INSTITUTE, WAKE FOREST SCHOOL OF MEDICINE.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
10  594  46 DEVELOPMENT AND FEASIBILITY OF A GROUP-BASED THERAPEUTIC YOGA PROGRAM FOR WOMEN WITH CHRONIC PELVIC PAIN. OBJECTIVE: TO DEVELOP A GROUP-BASED THERAPEUTIC YOGA PROGRAM FOR WOMEN WITH CHRONIC PELVIC PAIN (CPP) AND EXPLORE THE EFFECTS OF THIS PROGRAM ON PAIN SEVERITY, SEXUAL FUNCTION, AND WELL-BEING. METHODS: A YOGA THERAPY PROGRAM FOR CPP WAS DEVELOPED BY A MULTIDISCIPLINARY PANEL OF CLINICIANS, RESEARCHERS, AND YOGA CONSULTANTS. WOMEN REPORTING MODERATE TO SEVERE PELVIC PAIN FOR AT LEAST SIX MONTHS WERE RECRUITED INTO A SINGLE-ARM TRIAL. PARTICIPANTS ATTENDED TWICE WEEKLY GROUP CLASSES FOCUSING ON IYENGAR-BASED YOGA TECHNIQUES AND WERE INSTRUCTED TO PRACTICE YOGA AT HOME AN HOUR A WEEK FOR SIX WEEKS. PARTICIPANTS SELF-RATED THE SEVERITY OF THEIR PELVIC PAIN USING DAILY LOGS. THE IMPACT OF PARTICIPANTS' PAIN ON EVERYDAY ACTIVITIES, EMOTIONAL WELL-BEING, AND SEXUAL FUNCTION WAS ASSESSED USING AN IMPACT OF PELVIC PAIN (IPP) QUESTIONNAIRE. SEXUAL FUNCTION WAS FURTHER ASSESSED USING THE SEXUAL HEALTH OUTCOMES IN WOMEN QUESTIONNAIRE (SHOW-Q). RESULTS: AMONG THE 16 PARTICIPANTS (AGE RANGE = 31-64 YEARS), AVERAGE RATINGS OF THE SEVERITY OF PAIN "AT ITS WORST," "AT ITS BEST," AND "ON AVERAGE" DECREASED BY 29%, 32%, AND 34%, RESPECTIVELY, FROM START TO SIX WEEKS (P < 0.05 FOR ALL). WOMEN DEMONSTRATED IMPROVEMENTS IN SCORES ON IPP SUBSCALES FOR DAILY ACTIVITIES (1.8 +/- 0.7 TO 0.9 +/- 0.7, P < 0.001), EMOTIONAL WELL-BEING (1.7 +/- 0.9 TO 0.9 +/- 0.7, P = 0.005), AND SEXUAL FUNCTION (1.9 +/- 1.1 TO 1.0 +/- 0.9, P = 0.04). SCORES ON THE SHOW-Q "PELVIC PROBLEM INTERFERENCE" SCALE ALSO IMPROVED OVER SIX WEEKS (53 +/- 23 TO 27 +/- 23, P = 0.002). CONCLUSIONS: FINDINGS PROVIDE PRELIMINARY EVIDENCE OF THE FEASIBILITY OF TEACHING WOMEN WITH CPP TO PRACTICE YOGA TO SELF-MANAGE PAIN AND IMPROVE QUALITY OF LIFE AND SEXUAL FUNCTION.	2017	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
11 1233  48 FEASIBILITY AND PRELIMINARY EFFICACY OF TAILORED YOGA IN SURVIVORS OF HEAD AND NECK CANCER: A PILOT STUDY. PURPOSE: TREATMENT FOR HEAD AND NECK CANCER (HNC) RESULTS IN LONG-TERM TOXICITIES AND INCREASED PHYSICAL AND PSYCHOSOCIAL SURVIVOR BURDEN. THERE ARE A LIMITED NUMBER OF TREATMENTS FOR THESE LATE EFFECTS. YOGA POSTURES, BREATH WORK, RELAXATION, AND MEDITATION, MAY IMPROVE THESE LATE EFFECTS. THE PURPOSE OF THIS STUDY WAS TO EXAMINE THE FEASIBILITY OF A TAILORED YOGA PROGRAM IN HNC SURVIVORS AND OBTAIN PRELIMINARY EFFICACY DATA. METHODS: THIS WAS A RANDOMIZED WAIT-LIST CONTROL STUDY OF YOGA-NAIVE HNC SURVIVORS WHO WERE >3 MONTHS POST-CANCER TREATMENT. BASELINE DATA WERE COLLECTED. PARTICIPANTS WERE RANDOMIZED TO EITHER AN 8-WEEK HATHA YOGA INTERVENTION GROUP OR A WAIT-LIST GROUP. FEASIBILITY AND EFFICACY DATA WERE COLLECTED. AT 4 AND 8 WEEKS, PATIENTS UNDERWENT A REPEAT ASSESSMENT OF HEALTH. WAIT-LIST CONTROL GROUP PARTICIPANTS WERE OFFERED THE YOGA PROGRAM AFTER DATA COLLECTION. DESCRIPTIVE STATISTICS EVALUATED FEASIBILITY. MIXED EFFECTS GENERAL LINEAR MODELS WERE USED TO GENERATE ESTIMATES OF THE EFFICACY OUTCOMES. RESULTS: SEVENTY-THREE INDIVIDUALS WERE SCREENED AND 40 WERE ELIGIBLE. ALL ELIGIBLE INDIVIDUALS CONSENTED AND ENROLLED. FIVE OF THE INTERVENTION GROUP DISCONTINUED EARLY AND NONE IN THE WAIT-LIST CONTROL GROUP. FEASIBILITY WAS AFFIRMED AS PARTICIPANTS WERE RECRUITED AND RETAINED IN THE STUDY, THERE WERE NO ADVERSE EVENTS, FIDELITY TO PROTOCOL WAS DEMONSTRATED, AND SATISFACTION RATES WERE HIGH. EFFICACY MEASURES INDICATED POTENTIAL BENEFIT FOR SHOULDER RANGE OF MOTION ( D = 0.57-0.86, P < .05), PAIN ( D = 0.67-0.90, P </= .005), AND ANXIETY ( D = 0.59, P = .015). CONCLUSION: A TAILORED HATHA YOGA PROGRAM IS FEASIBLE AND POTENTIALLY EFFICACIOUS FOR HNC SURVIVORS. PRELIMINARY DATA SUPPORTS FURTHER INVESTIGATION OF YOGA IN THIS POPULATION IS NEEDED.	2018	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
12 2579  39 YOGA FOR HEALTH-RELATED QUALITY OF LIFE IN ADULT CANCER: A RANDOMIZED CONTROLLED FEASIBILITY STUDY. AN INCREASE IN PATIENT-LED UPTAKE OF COMPLEMENTARY THERAPIES IN ADULT CANCER HAS LED TO A NEED FOR MORE RIGOROUS STUDY OF SUCH INTERVENTIONS AND THEIR OUTCOMES. THIS STUDY THEREFORE AIMED TO EVALUATE THE FEASIBILITY AND ACCEPTABILITY OF A YOGA INTERVENTION IN MEN AND WOMEN RECEIVING CONVENTIONAL TREATMENT FOR A CANCER DIAGNOSIS. PROSPECTIVE, MIXED METHODS FEASIBILITY TRIAL ALLOCATED PARTICIPANTS TO RECEIVE ONE OF THREE YOGA INTERVENTIONS OVER A FOUR-WEEK STUDY PERIOD. DATA COLLECTION WAS COMPLETED THROUGH ONLINE SURVEY OF QOL-CA/CS AND CUSTOMIZED SURVEYS. FIFTEEN PARTICIPANTS WERE INCLUDED (11 FEMALE) UNDERGOING TREATMENT FOR BREAST, PROSTATE, COLORECTAL, BRAIN, AND BLOOD AND LUNG CANCER. TWO PARTICIPANTS DROPPED OUT AND COMPLETE QUALITATIVE AND QUANTITATIVE DATA SETS WERE COLLECTED FROM 12 PARTICIPANTS AND FOUR YOGA INSTRUCTORS. OTHER OUTCOME MEASURES INCLUDED IMPLEMENTATION COSTS PATIENT-REPORTED PREFERENCES FOR YOGA INTERVENTION AND CHANGES IN QOL-CA/CS. THREE TYPES OF YOGA INTERVENTION WERE SAFELY ADMINISTERED IN ADULT CANCER. MIXED METHODS, COST-EFFICIENCY, QOL-CA/CS, AND EVIDENCE-BASED DESIGN OF YOGA INTERVENTION HAVE BEEN USED TO ESTABLISH FEASIBILITY AND PATIENT-PREFERENCES FOR YOGA DELIVERY IN ADULT CANER. RESULTS SUGGEST THAT, WITH SOME METHODOLOGICAL IMPROVEMENTS, A LARGE-SCALE RANDOMIZED CONTROLLED TRIAL IS WARRANTED TO TEST THE EFFICACY OF YOGA FOR MALE AND FEMALE CANCER PATIENTS. THIS TRIAL IS REGISTERED WITH CLINICALTRIALS.GOV NCT02309112.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
13 1228  37 FEASIBILITY AND IMPACT OF A YOGA INTERVENTION ON COGNITION, PHYSICAL FUNCTION, PHYSICAL ACTIVITY, AND AFFECTIVE OUTCOMES AMONG PEOPLE LIVING WITH HIV: A RANDOMIZED CONTROLLED PILOT TRIAL. THE PURPOSE OF THIS PILOT RANDOMIZED CONTROLLED TRIAL IS TO ASSESS THE FEASIBILITY AND IMPACT OF A TRIWEEKLY 12-WEEK YOGA INTERVENTION AMONG PEOPLE LIVING WITH HIV (PLWH). ADDITIONAL OBJECTIVES INCLUDED EVALUATING COGNITION, PHYSICAL FUNCTION, MEDICATION ADHERENCE, HEALTH-RELATED QUALITY OF LIFE (HRQOL), AND MENTAL HEALTH AMONG YOGA PARTICIPANTS VERSUS CONTROLS USING BLINDED ASSESSORS. WE RECRUITED 22 MEDICALLY STABLE PLWH AGED >/=35 YEARS. A PRIORI FEASIBILITY CRITERIA WERE >/=70% YOGA SESSION ATTENDANCE AND >/=70% OF PARTICIPANTS SATISFIED WITH THE INTERVENTION USING A POSTPARTICIPATION QUESTIONNAIRE. TWO PARTICIPANTS WITHDREW FROM THE YOGA GROUP. MEAN YOGA CLASS ATTENDANCE WAS 82%, WITH 100% SATISFACTION. INTENTION-TO-TREAT ANALYSES (YOGA N = 11, CONTROL N = 11) SHOWED NO WITHIN- OR BETWEEN-GROUP DIFFERENCES IN COGNITIVE AND PHYSICAL FUNCTION. THE YOGA GROUP IMPROVED OVER TIME IN HRQOL COGNITION (P = .047) WITH TRENDS TOWARD IMPROVEMENTS IN HRQOL HEALTH TRANSITION (P =.063) AND DEPRESSION (P = .055). THIS PILOT STUDY PROVIDES PRELIMINARY EVIDENCE OF FEASIBILITY AND BENEFITS OF YOGA FOR PLWH.	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
14 1249  44 FEASIBILITY STUDY OF A MODIFIED YOGA PROGRAM FOR CHRONIC PAIN AMONG ELDERLY ADULTS IN ASSISTED AND INDEPENDENT LIVING. CONTEXT: YOGA IMPROVES QUALITY OF LIFE IN ELDERS >/=65 YEARS, BUT STUDIES AMONG ELDERS WITH CHRONIC PAIN ARE LIMITED. OBJECTIVE: CONDUCT A FEASIBILITY STUDY OF GENTLE YOGA AMONG ELDERS IN ASSISTED AND INDEPENDENT LIVING. DESIGN: SINGLE ARM PRE/POST CLINICAL TRIAL. SUBJECTS: ADULTS (>/=65 YEARS OF AGE) WITH SELF-IDENTIFIED CHRONIC PAIN (>/=3 ON A 10-POINT SCALE, LASTING FOR >/=3 MONTHS) AND NO CURRENT YOGA PRACTICE. INTERVENTION: TEN WEEKLY 60-MIN GENTLE YOGA CLASSES TAILORED TO ELDERLY ADULTS. OUTCOME MEASURES: AT BASELINE, WEEKS 5, 10 (END OF INTERVENTION), AND 20 (FOLLOW-UP), WE COLLECTED DATA ON FEASIBILITY (ADHERENCE, RETENTION, SAFETY), PAIN, ANXIETY, DEPRESSION, FATIGUE, SLEEP DISTURBANCE, AND PHYSICAL FUNCTION. RESULTS: TWENTY-SIX PARTICIPANTS ENROLLED (88% WOMEN, 77% WHITE, 58% IN ASSISTED LIVING) WITH AVERAGE AGE OF 86.6 +/- 4.4 (MEAN, STD). TWENTY PARTICIPANTS COMPLETED THE INTERVENTION, WITH 90% ADHERING (COMPLETING >/=6 CLASSES). NINE PARTICIPANTS (45% OF COMPLETERS) EXPERIENCED ADVERSE EVENTS, WHICH WERE NON-SERIOUS AND RELATED TO TRANSIENT MUSCULOSKELETAL PAIN. NO ADVERSE EVENTS RESULTED IN STUDY WITHDRAWAL. PARTICIPANTS REPORTED BEING SOMEWHAT LIKELY TO RECOMMEND YOGA TO A FRIEND, AND QUITE A BIT LIKELY TO DO YOGA AGAIN. AT THE END OF THE INTERVENTION, FOUR OF TWENTY PARTICIPANTS REPORTED PRACTICING YOGA OUTSIDE OF CLASS. ANXIETY SIGNIFICANTLY DECREASED FROM 5.80 (SE=0.90) TO 4.44 (SE=0.74) (P = 0.014), BUT THERE WERE NO CHANGES IN OTHER MEASURES. CONCLUSIONS: OUR PILOT 10-WEEK YOGA STUDY WAS GENERALLY SAFE FOR AND SUITABLE TO ASSISTED AND INDEPENDENT LIVING ELDERLY ADULTS. FUTURE STUDIES ARE NEEDED TO EXAMINE OTHER EFFECTS OF YOGA IN ASSISTED/INDEPENDENT LIVING ADULTS WITH CHRONIC PAIN.	2022	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
15 2603  35 YOGA FOR PEOPLE WITH CHRONIC PAIN IN A COMMUNITY-BASED SETTING: A FEASIBILITY AND PILOT RCT. THE PURPOSE OF THIS FEASIBILITY PILOT STUDY WAS TO ASSESS BENEFITS OF 8 WEEKS OF YOGA IN PEOPLE WITH CHRONIC PAIN. PARTICIPANTS COMPLETED BASELINE ASSESSMENTS AND WERE RANDOMIZED TO YOGA OR USUAL CARE. YOGA WAS OFFERED TWICE A WEEK FOR 8 WEEKS. WE ASSESSED FEASIBILITY AND THE BRIEF PAIN INVENTORY (BPI) WAS THE PRIMARY OUTCOME, ASSESSING PAIN-SEVERITY AND PAIN INTERFERENCE ON DAILY ACTIVITIES. EIGHTY-THREE PEOPLE WERE RECRUITED; 67 PEOPLE COMPLETED THE STUDY AND WERE INCLUDED IN THE ANALYSES. AVERAGE AGE OF PARTICIPANTS WAS 50.78 +/- 10.43 YEARS AND MOST PARTICIPANTS HAD PAIN >10 YEARS. THE INTERVENTION APPEARED FEASIBLE AND THERE WERE SIGNIFICANT IMPROVEMENTS (P < .05) IN MULTIPLE MEASURES FOR THE YOGA GROUP, INCLUDING A DECREASE IN BPI INTERFERENCE SCORES FROM 7.15 +/- 1.70 TO 6.14 +/- 2.21 (P = .007). THERE WAS A SIGNIFICANT DIFFERENCE IN BODY RESPONSIVENESS AND PAIN MANAGEMENT SCORES BETWEEN GROUPS AT 8 WEEKS. IT APPEARS THAT YOGA WAS FEASIBLE AND POSITIVELY INFLUENCED MULTIPLE OUTCOME MEASURES FOR PEOPLE WITH CHRONIC PAIN.	2019	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
16 2096  41 THE EFFECT OF YOGA EXERCISE ON IMPROVING DEPRESSION, ANXIETY, AND FATIGUE IN WOMEN WITH BREAST CANCER: A RANDOMIZED CONTROLLED TRIAL. BACKGROUND: DEPRESSION, ANXIETY, AND FATIGUE ARE AMONG THE MOST SIGNIFICANT PROBLEMS THAT INFLUENCE THE QUALITY OF LIFE OF PATIENTS WITH BREAST CANCER WHO RECEIVE ADJUVANT CHEMOTHERAPY. ALTHOUGH EVIDENCE HAS SHOWN YOGA TO DECREASE ANXIETY, DEPRESSION, AND FATIGUE IN PATIENTS WITH CANCER, FEW STUDIES ON THE EFFECTS OF YOGA HAVE TARGETED PATIENTS WITH BREAST CANCER. YOGA INTERVENTIONS SHOULD BE TESTED TO PROMOTE THE PSYCHOLOGICAL AND PHYSICAL HEALTH OF WOMEN WITH BREAST CANCER. PURPOSE: THIS STUDY EXAMINES THE EFFECTIVENESS OF AN 8-WEEK YOGA EXERCISE PROGRAM IN PROMOTING THE PSYCHOLOGICAL AND PHYSICAL HEALTH OF WOMEN WITH BREAST CANCER UNDERGOING ADJUVANT CHEMOTHERAPY IN TERMS OF DEPRESSION, ANXIETY, AND FATIGUE. METHODS: A SAMPLE OF 60 WOMEN WITH NONMETASTATIC BREAST CANCER WAS RECRUITED. PARTICIPANTS WERE RANDOMLY ASSIGNED INTO EITHER THE EXPERIMENTAL GROUP (N = 30) OR THE CONTROL GROUP (N = 30). A 60-MINUTE, TWICE-PER-WEEK YOGA EXERCISE WAS IMPLEMENTED FOR 8 WEEKS AS THE INTERVENTION FOR THE PARTICIPANTS IN THE EXPERIMENTAL GROUP. THE CONTROL GROUP RECEIVED STANDARD CARE ONLY. RESULTS: ANALYSIS USING THE JOHNSON-NEYMAN PROCEDURE FOUND THAT THE YOGA EXERCISE REDUCED OVERALL FATIGUE AND THE INTERFERENCE OF FATIGUE IN EVERYDAY LIFE FOR THE EXPERIMENTAL GROUP PARTICIPANTS. SIGNIFICANT REDUCTIONS WERE OBTAINED AFTER 4 WEEKS OF INTERVENTION PARTICIPATION FOR THOSE EXPERIMENTAL GROUP PATIENTS WITH RELATIVELY LOW STARTING BASELINE VALUES (BASELINE ITEM MEAN VALUE < 3.31 AND 3.22, RESPECTIVELY) AND AFTER 8 WEEKS FOR MOST PATIENTS (APPROXIMATELY 75%) WITH MODERATE STARTING BASELINE VALUES (BASELINE ITEM MEAN VALUE < 7.30 AND 5.34, RESPECTIVELY). THE 8-WEEK INTERVENTION DID NOT SIGNIFICANTLY IMPROVE THE LEVELS OF DEPRESSION (F = 1.29, P > .05) OR ANXIETY (F = 2.7, P > .05). CONCLUSIONS/IMPLICATIONS FOR PRACTICE: THE 8-WEEK YOGA EXERCISE PROGRAM DEVELOPED IN THIS STUDY EFFECTIVELY REDUCED FATIGUE IN PATIENTS WITH BREAST CANCER BUT DID NOT REDUCE DEPRESSION OR ANXIETY. ONCOLOGY NURSES SHOULD STRENGTHEN THEIR CLINICAL HEALTH EDUCATION AND APPLY YOGA TO REDUCE THE FATIGUE EXPERIENCED BY PATIENTS WITH BREAST CANCER WHO UNDERGO ADJUVANT CHEMOTHERAPY.	2014	
                                                                                                                                                                                                                                                                                                                                                                
17 2207  40 THE FEASIBILITY AND BENEFITS OF A 12-WEEK YOGA INTERVENTION FOR PEDIATRIC CANCER OUT-PATIENTS. BACKGROUND: INCREASING RATES OF SURVIVAL PRESENT A NEW SET OF PSYCHOSOCIAL AND PHYSICAL CHALLENGES FOR CHILDREN UNDERGOING TREATMENT FOR CANCER. PHYSICAL ACTIVITY (PA) HAS BEEN SHOWN TO BE A SAFE AND EFFECTIVE STRATEGY TO MITIGATE THE SIGNIFICANT BURDEN OF CANCER AND ITS TREATMENTS, WITH YOGA INCREASINGLY GAINING RECOGNITION AS A GENTLE ALTERNATIVE. THE PURPOSE OF THIS STUDY WAS TO DETERMINE THE FEASIBILITY AND BENEFITS OF A 12-WEEK COMMUNITY-BASED YOGA INTERVENTION ON HEALTH-RELATED QUALITY OF LIFE (HRQL), SELECT PHYSICAL FITNESS OUTCOMES AND PA LEVELS (PAL). PROCEDURE: EIGHT PEDIATRIC CANCER OUT-PATIENTS (4 MALE; 4 FEMALE; MAGE = 11.88, SD = 4.26) PARTICIPATED IN THE 12-WEEK INTERVENTION CONSISTING OF SUPERVISED YOGA SESSIONS 2 TIMES/WEEK. PARTICIPANTS (PATIENTS AND PARENT PROXIES) COMPLETED MEASURES ASSESSING HRQL, PHYSICAL FITNESS AND PAL AT BASELINE AND POST-INTERVENTION. RESULTS: RATES OF RECRUITMENT, RETENTION, ATTENDANCE AND ADVERSE EVENTS INDICATED THE PROGRAM WAS FEASIBLE. WILCOXON SIGNED RANK TESTS INDICATED SIGNIFICANT IMPROVEMENTS FOR PATIENT (P = 0.02) AND PARENT REPORTED HRQL (P = 0.03), FUNCTIONAL MOBILITY (P = 0.01), HAMSTRING FLEXIBILITY (LEFT, P = 0.01 AND RIGHT P = 0.02), AND TOTAL PAL (P = 0.02) PRE TO POST INTERVENTION. CONCLUSION: THIS 12-WEEK COMMUNITY-BASED YOGA INTERVENTION WAS FEASIBLE AND PROVIDES PRELIMINARY EVIDENCE FOR THE BENEFITS OF YOGA ON HRQL, PHYSICAL FITNESS AND PAL IN PEDIATRIC CANCER OUT-PATIENTS. IN A POPULATION WHERE SEDENTARY BEHAVIOR AND THE ASSOCIATED CO-MORBIDITIES ARE A GROWING CONCERN, THESE RESULTS PROMOTE THE CONTINUED EXPLORATION OF YOGA PROGRAMMING.	2014	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
18 1942  49 SAFETY AND FEASIBILITY OF MODIFIED CHAIR-YOGA ON FUNCTIONAL OUTCOME AMONG ELDERLY AT RISK FOR FALLS. FALLS ARE AMONG THE MOST COMMON PROBLEMS AFFECTING OLDER ADULTS. AT LEAST 50% OF THOSE OVER THE AGE OF 80 FALL ANNUALLY. THE GOAL OF THIS PILOT STUDY WAS TO ASSESS THE SAFETY AND FEASIBILITY OF STRUCTURED YOGA IN AN ELDERLY POPULATION WITH FALL RISK. SENIORS AT RISK FOR FALLS WERE IDENTIFIED AND ENROLLED IN A SINGLE ARM PILOT TRIAL. A CHAIR BASED YOGA PROGRAM WAS PROVIDED TWICE A WEEK FOR 8 WEEKS. THE PROGRAM WAS DESIGNED FROM PREVIOUSLY PUBLISHED PILOT DATA. A BATTERY OF VALIDATED INSTRUMENTS WAS ADMINISTERED AT BASELINE AND WEEK EIGHT AND WAS USED TO IDENTIFY WHICH INSTRUMENTS MAY BE SENSITIVE TO CHANGE AS A RESULT OF A YOGA PROGRAM. AMONG SIXTEEN SENIORS (MEDIAN AGE OF 88) WITH A PREVIOUS HISTORY OF FALLS, 87% PROVIDED DATA FOR ASSESSMENT AT THE END OF THE INTERVENTION. TWO PATIENTS WITHDREW, ONE DUE TO A FALL OUTSIDE THE INSTITUTION AND THE OTHER DUE TO LACK OF TIME AND INTEREST. THERE WERE NO ADVERSE EVENTS DURING THE YOGA SESSIONS. PAIRED-T TESTS COMPARED PRE-POST CHANGES AND GAINS WERE NOTED IN FEAR OF FALLING (5.27 TO 2.60; P = 0.029) AND SPPB SIT TO STAND SUBSCALE (0.31 TO 1.00; P =.022). IMPROVED TRENDS WERE NOTED IN ANXIETY AND THE TIMED UP AND GO ASSESSMENTS. WE FOUND THE MODIFIED CHAIR-YOGA PROGRAM IS SAFE AND RECRUITMENT IS FEASIBLE. OUR DATA SUGGESTS THAT YOGA MAY BE BENEFICIAL IN IMPROVING MOBILITY AND REDUCING FEAR OF FALLING WHICH WARRANTS ADDITIONAL RESEARCH VIA RANDOMIZED CONTROLLED TRIAL.	2012	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
19  459  39 CHANGES IN PAIN INTENSITY AND HEALTH RELATED QUALITY OF LIFE WITH IYENGAR YOGA IN NONSPECIFIC CHRONIC LOW BACK PAIN: A RANDOMIZED CONTROLLED STUDY. BACKGROUND: NONSPECIFIC CHRONIC LOW BACK (NCLBP) PAIN IS PREVALENT AMONG ADULT POPULATION AND OFTEN LEADS TO FUNCTIONAL LIMITATIONS, PSYCHOLOGICAL SYMPTOMS, LOWER QUALITY OF LIFE (QOL), AND HIGHER HEALTHCARE COSTS. THE PURPOSE OF THIS STUDY WAS TO DETERMINE THE EFFICACY OF IYENGAR YOGA THERAPY ON PAIN INTENSITY AND HEALTH RELATED QUALITY OF LIFE (HRQOL) WITH NCLBP. AIM OF THE STUDY: TO COMPARE THE EFFECT OF IYENGAR YOGA THERAPY AND CONVENTIONAL EXERCISE THERAPY ON PAIN INTENSITY AND HRQOL IN NONSPECIFIC CHRONIC LOW BACK PAIN. MATERIALS AND METHODS: EXPERIMENTAL STUDY WITH RANDOM SAMPLING TECHNIQUE. SUBJECTS/INTERVENTION: SIXTY SUBJECTS WHO FULFILLED THE SELECTION CRITERIA WERE RANDOMLY ASSIGNED TO IYENGAR YOGA (YOGA GROUP, N = 30) AND CONTROL GROUP (EXERCISE GROUP, N = 30). PARTICIPANTS COMPLETED LOW BACK PAIN EVALUATION FORM AND HRQOL-4 QUESTIONNAIRE BEFORE THEIR INTERVENTION AND AGAIN 4 WEEKS AND 6 MONTH LATER. YOGA GROUP UNDERWENT 29 YOGIC POSTURES TRAINING AND EXERCISE GROUP HAD UNDERGONE GENERAL EXERCISE PROGRAM FOR 4 WEEKS. STATISTICS: REPEATED MEASURES ANALYSIS OF VARIANCE (ANOVA) WAS USED TO ANALYZE GROUP DIFFERENCES OVER TIME, WHILE CONTROLLING FOR BASELINE DIFFERENCES. RESULTS: PATIENTS IN BOTH GROUPS EXPERIENCED SIGNIFICANT REDUCTION IN PAIN AND IMPROVEMENT IN HRQOL. IN VISUAL ANALOGUE SCALE (VAS) YOGA GROUP SHOWED REDUCTION OF 72.81% (P = 0.001) AS COMPARED TO EXERCISE GROUP 42.50% (P = 0.001). IN HRQOL, YOGA GROUP SHOWED REDUCTION OF 86.99% (P = 0.001) AS COMPARED TO EXERCISE GROUP 67.66% (P = 0.001). CONCLUSION: THESE RESULTS SUGGEST THAT IYENGAR YOGA PROVIDES BETTER IMPROVEMENT IN PAIN REDUCTION AND IMPROVEMENT IN HRQOL IN NONSPECIFIC CHRONIC BACK PAIN THAN GENERAL EXERCISE.	2014	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
20 2187  43 THE EFFECTS OF YOGA ON STUDENT MENTAL HEALTH: A RANDOMISED CONTROLLED TRIAL. BACKGROUND: UNIVERSITIES AROUND THE WORLD ARE FACING AN EPIDEMIC OF MENTAL DISTRESS AMONG THEIR STUDENTS. THE PROBLEM IS TRULY A PUBLIC HEALTH ISSUE, AFFECTING MANY AND WITH SERIOUS CONSEQUENCES. THE GLOBAL BURDEN OF DISEASE-AGENDA CALLS FOR EFFECTIVE INTERVENTIONS WITH LASTING EFFECTS THAT HAVE THE POTENTIAL TO IMPROVE THE MENTAL HEALTH OF YOUNG ADULTS. IN THIS STUDY WE AIMED TO DETERMINE WHETHER YOGA, A POPULAR AND WIDELY AVAILABLE MIND-BODY PRACTICE, CAN IMPROVE STUDENT MENTAL HEALTH. METHODS: WE PERFORMED A RANDOMISED CONTROLLED TRIAL WITH 202 HEALTHY UNIVERSITY STUDENTS IN THE OSLO AREA. THE PARTICIPANTS WERE ASSIGNED TO A YOGA GROUP OR WAITLIST CONTROL GROUP IN A 1:1 RATIO BY A SIMPLE ONLINE RANDOMISATION PROGRAM. THE INTERVENTION GROUP WAS OFFERED 24 YOGA SESSIONS OVER 12 WEEKS. MEASUREMENTS WERE TAKEN AT WEEK 0 (BASELINE), WEEK 12 (POST-INTERVENTION), AND WEEK 24 (FOLLOW-UP). THE PRIMARY OUTCOME WAS PSYCHOLOGICAL DISTRESS ASSESSED BY THE HSCL-25 QUESTIONNAIRE. ANALYSIS WAS PERFORMED BASED ON THE INTENTION TO TREAT-PRINCIPLE. RESULTS: BETWEEN 24 JANUARY 2017, AND 27 AUGUST 2017, WE RANDOMLY ASSIGNED 202 STUDENTS TO A YOGA INTERVENTION GROUP (N = 100), OR WAITLIST CONTROL GROUP (N = 102). COMPARED WITH THE CONTROL GROUP, THE YOGA PARTICIPANTS DEMONSTRATED A SIGNIFICANT REDUCTION IN DISTRESS SYMPTOMS BOTH AT POST-INTERVENTION (ADJUSTED DIFFERENCE IN THE MEAN CHANGE -0.15, 95% CI -0.26 TO -0.03, P = 0.0110) AND FOLLOW-UP (ADJUSTED DIFFERENCE IN THE MEAN CHANGE -0.18, 95% CI -0.29 TO -0.06, P = 0.0025). SLEEP QUALITY ALSO IMPROVED AT POST-INTERVENTION AND FOLLOW-UP. NO ADVERSE EVENTS WERE REPORTED. CONCLUSIONS: OUR FINDINGS SUGGEST THAT YOGA HAS A MODERATELY LARGE AND LASTING EFFECT, AT LEAST FOR SOME MONTHS, REDUCING SYMPTOMS OF DISTRESS AND IMPROVING SLEEP QUALITY AMONG STUDENTS. FURTHER RESEARCH SHOULD SEEK WAYS TO ENHANCE THE EFFECT, ASSESS AN EVEN LONGER FOLLOW-UP PERIOD, INCLUDE ACTIVE CONTROL GROUPS, AND CONSIDER PERFORMING SIMILAR STUDIES IN OTHER CULTURAL SETTINGS.TRIAL REGISTRATION: CLINICALTRIALS.GOV IDENTIFIER: NCT04258540.	2020