1 1149 166 ENHANCEMENT OF CANCER STEM CELL SUSCEPTIBILITY TO CONVENTIONAL TREATMENTS THROUGH COMPLEMENTARY YOGA THERAPY: POSSIBLE CELLULAR AND MOLECULAR MECHANISMS. CANCER STEM CELLS (CSCS) ARE STEM-LIKE TUMOR POPULATIONS THAT ARE REPORTED TO CONTRIBUTE TOWARDS TUMOR GROWTH, MAINTENANCE AND RECURRENCE AFTER THERAPY. HYPOXIA INCREASES CSC FRACTION AND PROMOTES ACQUISITION OF A STEM-CELL-LIKE STATE. CANCER STEM CELLS ARE CRITICALLY DEPENDANT ON THE HYPOXIA-INDUCIBLE FACTOR-1 (HIF-1) FOR SURVIVAL, SELF-RENEWAL, TUMOR GROWTH AND MAINTENANCE OF THEIR UNDIFFERENTIATED PHENOTYPE. RECENT RESEARCHES SHOW THAT STAGE OF DIFFERENTIATION OF THE TUMOR CELLS IS PREDICTIVE OF THEIR SUSCEPTIBILITY TO NATURAL KILLER CELL (NK) CELL MEDIATED CYTOTOXICITY AND CANCER STEM CELLS ARE SIGNIFICANT TARGETS OF NK CELL CYTOTOXICITY. STUDIES ALSO SHOW THAT REVERSION OF TUMOR CELLS TO A LESS-DIFFERENTIATED PHENOTYPE CAN BE ACHIEVED BY BLOCKING NFKAPPAB. YOGA THERAPY (YOGIC LIFESTYLE MODIFICATIONS ENCOMPASSING PHYSICAL POSTURES, BREATHING PRACTICES, RELAXATION TECHNIQUES AND MEDITATIONS) IS KNOWN TO MODULATE NEURAL, ENDOCRINE AND IMMUNE FUNCTIONS AT THE CELLULAR LEVEL THROUGH INFLUENCING CELL CYCLE CONTROL, AGING, OXIDATIVE STRESS, APOPTOSIS AND SEVERAL PATHWAYS OF STRESS SIGNALING MOLECULES. YOGA THERAPY HAS ALSO BEEN SHOWN TO ENHANCE NATURAL KILLER CELL ACTIVITY AND MODULATE STRESS AND DNA DAMAGE IN BREAST CANCER PATIENTS RECEIVING RADIOTHERAPY. RECENT STUDY FOUND THAT BRIEF DAILY YOGIC MEDITATION MAY REVERSE THE PATTERN OF INCREASED NFKAPPAB-RELATED TRANSCRIPTION OF PRO-INFLAMMATORY CYTOKINES IN LEUKOCYTES. THUS, YOGA THERAPY HAS THE POTENTIAL TO REDUCE CANCER STEM CELL SURVIVAL, SELF -RENEWAL AND TUMOR GROWTH BY MODIFYING THE TUMOR MICRO-ENVIRONMENT THROUGH VARIOUS MECHANISMS SUCH AS; 1) REDUCING HIF-1 ACTIVITY BY ENHANCED OXYGENATION, 2) PROMOTING NK CELL ACTIVITY DIRECTLY (OR INDIRECTLY THROUGH DOWN REGULATING NFKAPPAB EXPRESSION), THEREBY ENHANCING NK CELL MEDIATED CSC LYSIS, AND 3) BY MINIMIZING THE ABERRANT EXPRESSIONS OR ACTIVITIES OF VARIOUS HORMONES, CYTOKINES, CHEMOKINES AND TUMOR SIGNALING PATHWAYS. YOGA THERAPY MAY HAVE A SYNERGISTIC EFFECT WITH CONVENTIONAL MODALITIES OF TREATMENT IN PREVENTING CANCER PROGRESSION AND RECURRENCES. 2012 2 2224 45 THE IMPACT OF THE "YOGIC LIFESTYLE" ON CANCER PROGNOSIS AND SURVIVAL: CAN WE TARGET CANCER STEM CELLS WITH YOGA? CANCER HAS RECENTLY BEEN KNOWN TO ORIGINATE FROM STEM CELL-LIKE CELLS, CALLED CANCER STEM CELLS (CSCS). THEIR UNIQUE PROPERTIES OF SELF-DUPLICATION, MULTIPLICATION, AS WELL AS MIGRATION GIVE THE CSC RESISTANCE OVER CONVENTIONAL CANCER THERAPIES. NEWER THERAPIES ARE IN DEVELOPMENTAL STAGE TO TARGET THESE STEM CELL-LIKE POPULATIONS AND BECOME THE VANGUARD OF FUTURE TREATMENTS. SEVERAL COMPLEMENTARY AND ALTERNATIVE TREATMENTS HAVE BEEN USED IN CANCER MANAGEMENT AS AN ADJUNCT TO CONVENTIONAL THERAPY TO IMPROVE THE OVERALL QUALITY OF LIFE AND REDUCE RECURRENCE. YOGA STANDS AS THE THIRD MOST POPULAR OF ALL COMPLEMENTARY AND ALTERNATIVE MEDICINE TREATMENTS CURRENTLY USED IN CANCER PATIENTS TODAY. PRELIMINARY RESULTS SHOW THAT YOGA MODULATES NEURAL, HORMONAL, AND IMMUNE FUNCTIONS AT A CELLULAR LEVEL. THE SCOPE OF THIS COMMENTARY IS TO DISCUSS THE CURRENT EVIDENCE-BASED MEDICINE ON YOGA AND ITS EFFECT ON CSCS. 2017 3 1639 33 MODULATION OF IMMUNE RESPONSES IN STRESS BY YOGA. STRESS IS A CONSTANT FACTOR IN TODAY'S FASTPACED LIFE THAT CAN JEOPARDIZE OUR HEALTH IF LEFT UNCHECKED. IT IS ONLY IN THE LAST HALF CENTURY THAT THE ROLE OF STRESS IN EVERY AILMENT FROM THE COMMON COLD TO AIDS HAS BEEN EMPHASIZED, AND THE MECHANISMS INVOLVED IN THIS PROCESS HAVE BEEN STUDIED. STRESS INFLUENCES THE IMMUNE RESPONSE PRESUMABLY THROUGH THE ACTIVATION OF THE HYPOTHALAMIC-PITUITARY ADRENAL AXIS, HYPOTHALAMIC PITUITARY-GONADAL AXIS, AND THE SYMPATHETIC-ADRENAL-MEDULLARY SYSTEM. VARIOUS NEUROTRANSMITTERS, NEUROPEPTIDES, HORMONES, AND CYTOKINES MEDIATE THESE COMPLEX BIDIRECTIONAL INTERACTIONS BETWEEN THE CENTRAL NERVOUS SYSTEM (CNS) AND THE IMMUNE SYSTEM. THE EFFECTS OF STRESS ON THE IMMUNE RESPONSES RESULT IN ALTERATIONS IN THE NUMBER OF IMMUNE CELLS AND CYTOKINE DYSREGULATION. VARIOUS STRESS MANAGEMENT STRATEGIES SUCH AS MEDITATION, YOGA, HYPNOSIS, AND MUSCLE RELAXATION HAVE BEEN SHOWN TO REDUCE THE PSYCHOLOGICAL AND PHYSIOLOGICAL EFFECTS OF STRESS IN CANCERS AND HIV INFECTION. THIS REVIEW AIMS TO DISCUSS THE EFFECT OF STRESS ON THE IMMUNE SYSTEM AND EXAMINE HOW RELAXATION TECHNIQUES SUCH AS YOGA AND MEDITATION COULD REGULATE THE CYTOKINE LEVELS AND HENCE, THE IMMUNE RESPONSES DURING STRESS. 2008 4 2486 45 YOGA AS AN INTEGRATIVE APPROACH FOR PREVENTION AND TREATMENT OF ORAL CANCER. DESPITE TREMENDOUS ADVANCEMENTS IN MEDICINE, THE NUMBER OF ORAL CANCER CASES CONTINUES TO INCREASE, AND THE NEED FOR INTEGRATING ALTERNATE MEDICINE OR ADOPTING AN INTEGRATIVE APPROACH HAS BECOME A COMPELLING COST-EFFECTIVE REQUIREMENT FOR THE MANAGEMENT AND TREATMENT OF DISEASES. CONVENTIONAL TREATMENT OF ORAL CANCER INVOLVES SURGERY FOLLOWED BY RADIOTHERAPY WITH OR WITHOUT CHEMOTHERAPY WHICH CAUSES SEVERAL COMPLICATIONS INCLUDING POOR QUALITY OF LIFE AND HIGH CHANCES OF RECURRENCE OF CANCER. ORAL CANCER IS OFTEN LINKED WITH OBESITY WHICH IS MAJOR RISK FACTORS IN OTHER CANCERS. APART FROM OBESITY, ORAL CANCER IS THOUGHT TO HAVE AN INVERSE RELATION WITH NEURODEGENERATIVE DISORDERS PRESUMABLY BECAUSE CELL DEATH DECREASES IN THE FORMER CASE AND INCREASES IN THE LATTER. ANCIENT MIND-BODY TECHNIQUES SUCH AS YOGA HAVE NOT BEEN ADEQUATELY TESTED AS A TOOL TO SYNERGIZE THE CELLULAR EQUILIBRIUM PERTAINING TO THE TREATMENT OF ORAL CANCER. NERVE GROWTH FACTOR (NGF), TUMOR NECROSIS FACTOR-ALPHA (TNF-ALPHA), AND INTERLEUKIN-6 (IL-6) ARE AMONG THE EARLY EXPERIMENTAL CELLULAR BIOMARKERS THAT MAY BE USED TO PROBE THE MODULATION OF ORAL CANCER, OBESITY, AND NEURODEGENERATIVE DISORDERS. YOGA HAS BEEN REPORTED TO INFLUENCE THESE MOLECULES IN HEALTHY INDIVIDUALS BUT WHETHER THEIR EXPRESSION CAN BE ALTERED IN PATIENTS OF ORAL CANCER BY YOGA INTERVENTION IS THE SUBJECT OF THIS RESEARCH BEING DISCUSSED IN THIS REVIEW ARTICLE. THEREFORE, THE PRESENT ARTICLE NOT ONLY REVIEWS THE CURRENT STATUS OF RESEARCH STUDIES IN ORAL CANCER, OBESITY, AND NEURODEGENERATIVE DISORDERS BUT ALSO HOW THESE ARE LINKED TO EACH OTHER AND WHY THE INVESTIGATIONS OF THE PUTATIVE NGF PATHWAY, INVOLVING TNF-ALPHA AND IL-6, COULD PROVIDE USEFUL CLUES TO UNDERSTAND THE MOLECULAR EFFECTS BROUGHT ABOUT BY YOGA INTERVENTION IN SUCH PATIENTS. 2018 5 2272 35 THE ROLE OF YOGA IN INFLAMMATORY MARKERS. YOGA IS AN ANCIENT SYSTEM FOR INTEGRATING THE MIND, BODY, AND SPIRIT. IN THE HATHA YOGA ASHTANGA TRADITION (THE EIGHT LIMB PATANJALI YOGA), THREE OF THE LIMBS ARE MEDITATION, BREATHWORK (PRANAYAMA) AND PHYSICAL POSTURES (ASANA), WHICH ARE WIDELY PRACTISED IN YOGA CLASSES. THE BENEFITS OF YOGA FOR MENTAL AND PHYSICAL HEALTH ARE ROOTED IN THE PRACTICE'S ORIGINS: IN YOGA, STRESS IS SAID TO BE THE ROOT OF ALL DISEASES. THE ESTABLISHED FIELDS OF PSYCHONEUROIMMUNOLOGY AND IMMUNOPSYCHIATRY STUDY THE INTERPLAY BETWEEN THE IMMUNE SYSTEM AND MOOD OR MENTAL STATES. THIS MINI-REVIEW HAS SHIFTED THE EMPHASIS FROM RESEARCH THAT FOCUSES ON YOGA'S BENEFITS FOR STRESS, THE MOST COMMONLY STUDIED OUTCOME OF YOGA RESEARCH, TO A SUMMARY OF THE RESEARCH ON THE EFFECTS OF YOGA PRACTICES ON THE IMMUNE SYSTEM. THE CURRENT LITERATURE BEARS STRONG EVIDENCE FOR THE BENEFITS OF YOGA ON THE LEVELS OF CIRCULATING CORTISOL AND CLASSICAL INFLAMMATORY MARKERS, SUCH AS C-REACTIVE PROTEIN (CRP) AND CYTOKINES SUCH AS INTERLEUKIN-1 BETA (IL-1BETA), INTERLEUKIN 6 (IL-6), TUMOUR NECROSIS FACTOR-ALPHA (TNF-ALPHA) AND INTERFERON-GAMMA (INF-GAMMA). THE EVIDENCE FOR OTHER LESS STUDIED MARKERS, TELOMERASE ACTIVITY, BETA-ENDORPHINS, IMMUNOGLOBULIN A (IGA) AND BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) IS ALSO GROWING. THIS MINI-REVIEW CENTRES AROUND THE INTERPLAY BETWEEN YOGA AND THESE MARKERS IN STRESS MANAGEMENT AND DEPRESSION, VASCULAR AND IMMUNE FUNCTION IN THE OLDER POPULATION, CARDIOVASCULAR AND METABOLIC DISEASES, AUTO-IMMUNE DISEASES, BREAST CANCER AND PREGNANCY. OVERALL, THE LITERATURE EXAMINED REVEALS THE NOVELTY OF THIS FIELD OF RESEARCH AND SHEDS LIGHT ON METHODOLOGICAL CHALLENGES; HOWEVER, IT UNCOVERS THE POTENTIAL FOR YOGA TO BE USED AS ADJUVANT THERAPY IN CONDITIONS WITH AN INFLAMMATORY COMPONENT. 2022 6 1890 37 REGULATION OF GENE EXPRESSION BY YOGA, MEDITATION AND RELATED PRACTICES: A REVIEW OF RECENT STUDIES. INTEGRATIVE MEDICINE (IM) APPROACHES HAVE GAINED SIGNIFICANT INTEREST IN RECENT YEARS TO PROVIDE A SOLUTION FOR THE HEALTH CARE CHALLENGES WE FACE TODAY. YOGIC COGNITIVE-BEHAVIORAL PRACTICES ARE AMONG THE MOST WIDELY USED IM APPROACHES AND INCLUDE DIVERSE PRACTICES SUCH AS YOGA ASANAS, MEDITATION, BREATHING EXERCISES, QI GONG, TAI CHI CHIH, AND VARIOUS OTHERS. STUDIES TO DATE SUGGEST THAT THESE YOGIC/MEDITATIVE PRACTICES HAVE SIGNIFICANT POSITIVE EFFECTS ON THE MIND-BODY SYSTEM AND THEREBY CAN INCREASE WELLNESS AND SUPPORT THE HEALING PROCESS FROM DISEASE. PREVIOUS WORK HAS PROVIDED EVIDENCE FOR BOTH PSYCHOLOGICAL AND PHYSIOLOGICAL EFFECTS OF THESE PRACTICES; HOWEVER, THE MECHANISMS OF THESE EFFECTS, ESPECIALLY AT THE MOLECULAR LEVEL, HAVE LARGELY BEEN MISSING. THREE RECENT STUDIES STARTED TO PROVIDE SOME OF THIS INFORMATION THROUGH GENE EXPRESSION PROFILING IN CIRCULATING IMMUNE CELLS, WHICH SUPPORT THE HYPOTHESIS THAT YOGIC/MEDITATIVE PRACTICES HAVE A MEASURABLE EFFECT AT THE MOLECULAR LEVEL. THESE STUDIES ARE REVIEWED HEREIN AND SOME FUTURE PERSPECTIVES ARE CONSIDERED. 2013 7 1873 36 RAPID GENE EXPRESSION CHANGES IN PERIPHERAL BLOOD LYMPHOCYTES UPON PRACTICE OF A COMPREHENSIVE YOGA PROGRAM. ONE OF THE MOST COMMON INTEGRATIVE MEDICINE (IM) MODALITIES IS YOGA AND RELATED PRACTICES. PREVIOUS WORK HAS SHOWN THAT YOGA MAY IMPROVE WELLNESS IN HEALTHY PEOPLE AND HAVE BENEFITS FOR PATIENTS. HOWEVER, THE MECHANISMS OF HOW YOGA MAY POSITIVELY AFFECT THE MIND-BODY SYSTEM ARE LARGELY UNKNOWN. HERE WE HAVE ASSESSED POSSIBLE RAPID CHANGES IN GLOBAL GENE EXPRESSION PROFILES IN THE PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMCS) IN HEALTHY PEOPLE THAT PRACTICED EITHER A COMPREHENSIVE YOGA PROGRAM OR A CONTROL REGIMEN. THE EXPERIMENTAL SESSIONS INCLUDED GENTLE YOGA POSTURES, BREATHING EXERCISES, AND MEDITATION (SUDARSHAN KRIYA AND RELATED PRACTICES--SK&P) COMPARED WITH A CONTROL REGIMEN OF A NATURE WALK AND LISTENING TO RELAXING MUSIC. WE SHOW THAT THE SK&P PROGRAM HAS A RAPID AND SIGNIFICANTLY GREATER EFFECT ON GENE EXPRESSION IN PBMCS COMPARED WITH THE CONTROL REGIMEN. THESE DATA SUGGEST THAT YOGA AND RELATED PRACTICES RESULT IN RAPID GENE EXPRESSION ALTERATIONS WHICH MAY BE THE BASIS FOR THEIR LONGER TERM CELL BIOLOGICAL AND HIGHER LEVEL HEALTH EFFECTS. 2013 8 527 46 COMPARISON OF LYMPHOCYTE APOPTOTIC INDEX AND QUALITATIVE DNA DAMAGE IN YOGA PRACTITIONERS AND BREAST CANCER PATIENTS: A PILOT STUDY. BACKGROUND: YOGA IS FOUND TO BE EFFECTIVE IN REDUCING STRESS LEVELS AND RADIATION-INDUCED DNA DAMAGE, AND IMPROVING THE QUALITY OF LIFE, IN BREAST CANCER PATIENTS. THE PRESENT STUDY WAS AIMED AT COMPARING THE APOPTOTIC INDEX (AI) AND DNA DAMAGE OF ADVANCED YOGA PRACTITIONERS WITH THOSE OF BREAST CANCER PATIENTS. MATERIALS AND METHODS: THIS CROSS-SECTIONAL PILOT STUDY COMPARED THREE GROUPS (N = 9 EACH) OF AGE-MATCHED SUBJECTS VIZ. (1) CARCINOMA BREAST PATIENTS IN STAGE II OR III UNDERGOING RADIATION THERAPY AFTER COMPLETING THREE CYCLES OF CHEMOTHERAPY; (2) SENIOR YOGA PRACTITIONERS WHO WERE PRACTICING ASANAS, PRANAYAMA AND MEDITATION DAILY FOR MORE THAN 10 YEARS; AND (3) NORMAL HEALTHY VOLUNTEERS. PERIPHERAL BLOOD LYMPHOCYTES WERE ISOLATED, AND QUALITATIVE DNA DAMAGE (QDD) AND AI WERE EVALUATED BY SINGLE-CELL GEL ELECTROPHORESIS ASSAY. APPROXIMATELY 500 CELLS WERE COUNTED IN EACH CASE. NUMBER OF CELLS THAT WERE NORMAL, UNDERGOING APOPTOSIS, AND WITH DNA DAMAGE WERE CATEGORIZED AND PERCENTAGES WERE CALCULATED. RESULTS: DATA BEING NORMALLY DISTRIBUTED, ONE-WAY ANALYSIS OF VARIANCE (ANOVA) SHOWED SIGNIFICANT INTERACTION BETWEEN GROUPS IN AI (P = 0.016) AND QDD (P = 0.045). ON POST-HOC ANALYSIS USING SCHEFFE TEST, AI WAS SIGNIFICANTLY LOWER IN NON-YOGA VOLUNTEERS AS COMPARED WITH THE BREAST CANCER GROUP (P = 0.019) AND QDD WAS SIGNIFICANTLY LOWER IN YOGA PRACTITIONERS WHEN COMPARED WITH NON-YOGA VOLUNTEERS (P = 0.047). CONCLUSION: CELLULAR DYSFUNCTION (QDD) REQUIRES RESTORATIVE MECHANISMS (AI) TO RESTORE THE SYSTEM TO A BALANCE. THE RESULTS OF THIS PILOT STUDY SHOW TRENDS, WHICH INDICATE THAT IN ILL-HEALTH, THERE IS INADEQUATE RESTORATIVE MECHANISMS (AI) ALTHOUGH DYSFUNCTION (QDD) IS HIGH. THROUGH REGULAR PRACTICE OF YOGA, CELLULAR DYSFUNCTION CAN BE LOWERED, THUS NECESSITATING REDUCED RESTORATIVE MECHANISMS. AI AND QDD COULD ALSO BE USEFUL INDICATORS FOR PREDICTING THE THREE ZONES OF HEALTH VIZ. DISEASE, HEALTH, AND POSITIVE HEALTH. 2013 9 2768 40 YOGA REDUCES INFLAMMATORY SIGNALING IN FATIGUED BREAST CANCER SURVIVORS: A RANDOMIZED CONTROLLED TRIAL. BACKGROUND: YOGA IS A POPULAR MIND-BODY THERAPY THAT HAS DEMONSTRATED BENEFICIAL EFFECTS ON PSYCHOLOGICAL, BEHAVIORAL, AND FUNCTIONAL OUTCOMES. HOWEVER, FEW STUDIES HAVE INVESTIGATED EFFECTS ON INFLAMMATORY PROCESSES. THIS STUDY TESTED THE HYPOTHESIS THAT AN IYENGAR YOGA INTERVENTION SPECIFICALLY DESIGNED FOR FATIGUED BREAST CANCER SURVIVORS WOULD LEAD TO DECREASES IN INFLAMMATION-RELATED GENE EXPRESSION AND CIRCULATING MARKERS OF PROINFLAMMATORY CYTOKINE ACTIVITY. METHODS: BREAST CANCER SURVIVORS WITH PERSISTENT CANCER-RELATED FATIGUE WERE RANDOMIZED TO A 12-WEEK IYENGAR YOGA INTERVENTION (N=16) OR A 12-WEEK HEALTH EDUCATION CONTROL CONDITION (N=15). BLOOD SAMPLES WERE COLLECTED AT BASELINE, POST-INTERVENTION, AND AT A 3-MONTH FOLLOW-UP FOR GENOME-WIDE TRANSCRIPTIONAL PROFILING AND BIOINFORMATIC ANALYSES. PLASMA INFLAMMATORY MARKERS AND SALIVARY CORTISOL WERE ALSO ASSESSED. RESULTS: IN PROMOTER-BASED BIOINFORMATICS ANALYSES, THE YOGA GROUP SHOWED REDUCED ACTIVITY OF THE PRO-INFLAMMATORY TRANSCRIPTION FACTOR NUCLEAR FACTOR KAPPA B (NF-KAPPAB), INCREASED ACTIVITY OF THE ANTI-INFLAMMATORY GLUCOCORTICOID RECEPTOR, AND REDUCED ACTIVITY OF CAMP RESPONSE ELEMENT-BINDING PROTEIN (CREB) FAMILY TRANSCRIPTION FACTORS RELATIVE TO CONTROLS (ALL PS<.05). THERE WAS ALSO A SIGNIFICANT INTERVENTION EFFECT ON THE SOLUBLE TUMOR NECROSIS FACTOR RECEPTOR TYPE II (STNF-RII), A MARKER OF TNF ACTIVITY; PLASMA LEVELS OF STNF-RII REMAINED STABLE IN THE YOGA GROUP, WHEREAS LEVELS OF THIS MARKER INCREASED IN THE HEALTH EDUCATION GROUP (P=.028). A SIMILAR, NON-SIGNIFICANT TREND WAS OBSERVED FOR THE INTERLEUKIN 1 RECEPTOR ANTAGONIST (P=.16). NO SIGNIFICANT CHANGES IN C REACTIVE PROTEIN (CRP), INTERLEUKIN 6 (IL-6), OR DIURNAL CORTISOL MEASURES WERE OBSERVED. CONCLUSIONS: A 12-WEEK RESTORATIVE IYENGAR YOGA INTERVENTION REDUCED INFLAMMATION-RELATED GENE EXPRESSION IN BREAST CANCER SURVIVORS WITH PERSISTENT FATIGUE. THESE FINDINGS SUGGEST THAT A TARGETED YOGA PROGRAM MAY HAVE BENEFICIAL EFFECTS ON INFLAMMATORY ACTIVITY IN THIS PATIENT POPULATION, WITH POTENTIAL RELEVANCE FOR BEHAVIORAL AND PHYSICAL HEALTH. 2014 10 1587 27 MEDICAL YOGA THERAPY. MEDICAL YOGA IS DEFINED AS THE USE OF YOGA PRACTICES FOR THE PREVENTION AND TREATMENT OF MEDICAL CONDITIONS. BEYOND THE PHYSICAL ELEMENTS OF YOGA, WHICH ARE IMPORTANT AND EFFECTIVE FOR STRENGTHENING THE BODY, MEDICAL YOGA ALSO INCORPORATES APPROPRIATE BREATHING TECHNIQUES, MINDFULNESS, AND MEDITATION IN ORDER TO ACHIEVE THE MAXIMUM BENEFITS. MULTIPLE STUDIES HAVE SHOWN THAT YOGA CAN POSITIVELY IMPACT THE BODY IN MANY WAYS, INCLUDING HELPING TO REGULATE BLOOD GLUCOSE LEVELS, IMPROVE MUSCULOSKELETAL AILMENTS AND KEEPING THE CARDIOVASCULAR SYSTEM IN TUNE. IT ALSO HAS BEEN SHOWN TO HAVE IMPORTANT PSYCHOLOGICAL BENEFITS, AS THE PRACTICE OF YOGA CAN HELP TO INCREASE MENTAL ENERGY AND POSITIVE FEELINGS, AND DECREASE NEGATIVE FEELINGS OF AGGRESSIVENESS, DEPRESSION AND ANXIETY. 2017 11 1590 23 MEDITATION AND YOGA CAN MODULATE BRAIN MECHANISMS THAT AFFECT BEHAVIOR AND ANXIETY-A MODERN SCIENTIFIC PERSPECTIVE. MEDITATION AND YOGA TECHNIQUES ARE RECEIVING INCREASED ATTENTION THROUGHOUT THE WORLD, DUE TO THE ACCUMULATION OF EVIDENCE BASED RESEARCH THAT PROVES THE DIRECT AND INDIRECT BENEFITS OF SUCH PRACTICES. BASED ON STUDIES CONDUCTED SO FAR, IT HAS BEEN FOUND THAT THE PRACTICE OF MEDITATION TRIGGERS NEUROTRANSMITTERS THAT MODULATE PSYCHOLOGICAL DISORDERS SUCH AS ANXIETY. THIS PAPER WILL REVIEW THE PSYCHOLOGICAL EFFECTS OF THE PRACTICE OF MEDITATION, THE ROLE OF NEUROTRANSMITTERS, AND STUDIES USING EEG AND FMRI. 2015 12 2776 30 YOGA SCHOOL OF THOUGHT AND PSYCHIATRY: THERAPEUTIC POTENTIAL. YOGA IS A TRADITIONAL LIFE-STYLE PRACTICE USED FOR SPIRITUAL REASONS. HOWEVER, THE PHYSICAL COMPONENTS LIKE THE ASANAS AND PRANAYAAMAS HAVE DEMONSTRATED PHYSIOLOGICAL AND THERAPEUTIC EFFECTS. THERE IS EVIDENCE FOR YOGA AS BEING A POTENT ANTIDEPRESSANT THAT MATCHES WITH DRUGS. IN DEPRESSIVE DISORDER, YOGA 'CORRECTS' AN UNDERLYING COGNITIVE PHYSIOLOGY. IN SCHIZOPHRENIA PATIENTS, YOGA HAS BENEFITS AS AN ADD-ON INTERVENTION IN PHARMACOLOGICALLY STABILIZED SUBJECTS. THE EFFECTS ARE PARTICULARLY NOTABLE ON NEGATIVE SYMPTOMS. YOGA ALSO HELPS TO CORRECT SOCIAL COGNITION. YOGA CAN BE INTRODUCED EARLY IN THE TREATMENT OF PSYCHOSIS WITH SOME BENEFITS. ELEVATION OF OXYTOCIN MAY BE A MECHANISM OF YOGA EFFECTS IN SCHIZOPHRENIA. CERTAIN COMPONENTS OF YOGA HAVE DEMONSTRATED NEUROBIOLOGICAL EFFECTS SIMILAR TO THOSE OF VAGAL STIMULATION, INDICATING THIS (INDIRECT OR AUTOGENOUS VAGAL STIMULATION) AS A POSSIBLE MECHANISM OF ITS ACTION. IT IS TIME, PSYCHIATRISTS EXPLOITED THE BENEFITS IF YOGA FOR A COMPREHENSIVE CARE IN THEIR PATIENTS. 2013 13 406 39 BIOLOGICAL MARKERS FOR THE EFFECTS OF YOGA AS A COMPLEMENTARY AND ALTERNATIVE MEDICINE. FROM THE LAST FEW DECADES, THERE ARE INCREASING INCIDENCES OF DISORDERS LIKE PREMATURE AGING, CARDIOVASCULAR DISEASE, MULTIPLE SCLEROSIS, FIBROMYALGIA, AND ALZHEIMER'S DISEASE IN ADDITION TO MEDICATION, RESEARCHERS HAVE FOUND THAT YOGA, A MIND-BODY THERAPY, CAN BE USED AS AN ALTERNATIVE MEDICINE. YOGA COMBINES SPECIFIC PHYSICAL POSTURES, BREATHING TECHNIQUES, RELAXATION AND MEDITATION THAT IMPROVE MENTAL AND PHYSICAL HEALTH OF THE BODY. THE PURPOSE OF THIS REVIEW IS TO COLLATE THE RESEARCH EVIDENCES CLAIMING HEALTH BENEFITS OF PERFORMING TRADITIONAL YOGIC PRACTICES. WHAT ARE THE BIOLOGICAL AND OTHER RELIABLE INDICATORS TO SUGGEST THAT DOING ASANAS, PRANAYAMA, AND MEDITATION COULD REDUCE OR TREAT WIDE RANGE OF LIFE STYLE DISORDERS ARE DISCUSSED. IMPORTANTLY, THESE INDICATORS ARE OTHERWISE USED TO ASSESS THE SEVERITY OF DISORDERS. IN MANY OF THE STUDY IT HAS BEEN SHOWN THAT YOGA IMPROVES THE REDOX HEALTH OF BODY WHOSE IMBALANCE HAS BEEN WELL PROVEN TO CAUSE MANY HEALTH COMPLICATIONS. THE IMPACT OF YOGA ON NEURODEGENERATIVE DISEASES HAVE REVEALED THAT IT REVERSES MEMORY LOSS, REDUCE ANXIETY, DEPRESSION AND STRESS, THE BIOLOGICAL INDICATORS OF DISEASE. HOWEVER, MOST STUDIES HAVE SEVERAL LIMITATIONS AND THEREFORE FURTHER RESEARCH INTO YOGA IS NEEDED TO VALIDATE THESE FINDINGS. 2019 14 1937 26 ROLE OF YOGA IN THE TREATMENT OF NEUROTIC DISORDERS: CURRENT STATUS AND FUTURE DIRECTIONS. A LARGE NUMBER OF STUDIES HAVE CONSISTENTLY DEMONSTRATED THE POTENTIAL OF YOGA, NOT ONLY IN THE TREATMENT OF PSYCHIATRIC AND PSYCHOSOMATIC DISORDER BUT ALSO IN PROMOTING POSITIVE PHYSICAL AND MENTAL HEALTH. THIS PAPER REVIEWS VARIOUS STUDIES ON THE TREATMENT OF NEUROSIS WITH TECHNIQUES DERIVED FROM YOGA. A FEW LACUNAE HAVE BEEN IDENTIFIED AND POSSIBLE DIRECTIONS FOR FUTURE RESEARCH ARE OUTLINED. IT IS HOPED THAT RESEARCH ALONG THESE LINES WILL DEVELOP A STANDARDIZED METHOD OF YOGA THERAPY WHICH CAN BE UTILIZED AND INTEGRATED WITHIN THE EXISTING METHODS OF TREATMENT OF NEUROTIC DISORDERS. 1994 15 226 29 A SYSTEMATIC REVIEW OF RANDOMISED CONTROL TRIALS ON THE EFFECTS OF YOGA ON STRESS MEASURES AND MOOD. STRESS RELATED DISORDERS SUCH AS DEPRESSION AND ANXIETY ARE LEADING SOURCES OF DISABILITY WORLDWIDE, AND CURRENT TREATMENT METHODS SUCH AS CONVENTIONAL ANTIDEPRESSANT MEDICATIONS ARE NOT BENEFICIAL FOR ALL INDIVIDUALS. THERE IS EVIDENCE THAT YOGA HAS MOOD-ENHANCING PROPERTIES POSSIBLY RELATED TO ITS INHIBITORY EFFECTS ON PHYSIOLOGICAL STRESS AND INFLAMMATION, WHICH ARE FREQUENTLY ASSOCIATED WITH AFFECTIVE DISORDERS. HOWEVER THE BIOLOGICAL MECHANISMS VIA WHICH YOGA EXERTS ITS THERAPEUTIC MOOD-MODULATING EFFECTS ARE LARGELY UNKNOWN. THIS SYSTEMATIC REVIEW INVESTIGATES THE EFFECTS OF YOGA ON SYMPATHETIC NERVOUS SYSTEM AND HYPOTHALAMIC PITUITARY ADRENAL AXIS REGULATION MEASURES. IT FOCUSES ON STUDIES COLLECTING PHYSIOLOGICAL PARAMETERS SUCH AS BLOOD PRESSURE, HEART RATE, CORTISOL, PERIPHERAL CYTOKINE EXPRESSION AND/OR STRUCTURAL AND FUNCTIONAL BRAIN MEASURES IN REGIONS INVOLVED IN STRESS AND MOOD REGULATION. OVERALL THE 25 RANDOMISED CONTROL STUDIES DISCUSSED PROVIDE PRELIMINARY EVIDENCE TO SUGGEST THAT YOGA PRACTICE LEADS TO BETTER REGULATION OF THE SYMPATHETIC NERVOUS SYSTEM AND HYPOTHALAMIC-PITUITARY-ADRENAL SYSTEM, AS WELL AS A DECREASE IN DEPRESSIVE AND ANXIOUS SYMPTOMS IN A RANGE OF POPULATIONS. FURTHER RESEARCH IS WARRANTED TO CONFIRM THESE PRELIMINARY FINDINGS AND FACILITATE IMPLEMENTATION IN CLINICAL SETTINGS. 2015 16 2366 30 WAR-RELATED MENTAL HEALTH ISSUES AND NEED FOR YOGA INTERVENTION STUDIES: A SCOPING REVIEW. CONFLICTS AND HUMANITARIAN CRISES LEAD TO SERIOUS MENTAL HEALTH DISORDERS, INCLUDING DEPRESSION, ANXIETY, STRESS, AND COGNITIVE DECLINE. EXPOSURE TO THESE CIRCUMSTANCES IN EARLY LIFE CAN LEAD TO THE DEVELOPMENT OF DISORDERS SUCH AS MILD COGNITIVE IMPAIRMENT, DEMENTIA, AND ALZHEIMER'S DISEASE (AD), FOR WHICH NO TREATMENTS ARE AVAILABLE. IN THIS REVIEW, VARIOUS RESEARCH PAPERS HAVE BEEN COMPILED TO DEVELOP AN UNDERSTANDING ABOUT MENTAL HEALTH OF POPULATION AFFECTED DUE TO WARS AND CONFLICTS AND HOW STRESS AND DEPRESSION CAN ACCELERATE THE DEVELOPMENT OF DEMENTIA AND AD. DUE TO FAILURE OF DRUGS IN THE TREATMENT OF DEMENTIA AND AD, YOGA AND MINDFULNESS-BASED APPROACH HAS BEEN PROPOSED FOR FUTURE INVESTIGATIONS. ALTHOUGH STUDIES HAVE SHOWN THAT YOGA AND MINDFULNESS CAN BE HELPFUL IN THE MANAGEMENT OF STRESS, ANXIETY, DEPRESSION, AND POSTTRAUMATIC STRESS DISORDER IN THE WAR-AFFLICTED AREAS, LIMITED MECHANISTIC STUDIES IN YOGA AND MINDFULNESS REMAIN THE CHIEF CAUSE PRECLUDING ITS CLINICAL APPLICATION IN SUCH WARZONES. THE MOLECULAR STUDIES IN THE FIELD OF YOGA CAN BE UNDERTAKEN BY TARGETING THESE WARZONES. THIS REVIEW PROVIDES A SCIENTIFIC EVALUATION OF MIND-BODY TECHNIQUES AS A JUSTIFICATION FOR MENTAL HEALTH REHABILITATION IN THE WAR-AFFLICTED ZONES IN FACE OF FAILED CLINICAL TRIALS FOR VARIOUS DRUGS. THIS MAY HELP REDUCE THE RISK OF DEVELOPING DEMENTIA AND AD IN THIS SUSCEPTIBLE POPULATION. 2021 17 1734 29 PERSPECTIVES ON YOGA INPUTS IN THE MANAGEMENT OF CHRONIC PAIN. CHRONIC PAIN IS MULTI-DIMENSIONAL. AT THE PHYSICAL LEVEL ITSELF, BEYOND THE NOCICEPTIVE PATHWAY, THERE IS HYPER AROUSAL STATE OF THE COMPONENTS OF THE NERVOUS SYSTEM, WHICH NEGATIVELY INFLUENCES TENSION COMPONENT OF THE MUSCLES, PATTERNS OF BREATHING, ENERGY LEVELS AND MINDSET, ALL OF WHICH EXACERBATE THE DISTRESS AND AFFECT THE QUALITY OF LIFE OF THE INDIVIDUAL AND FAMILY. BEGINNING WITH THE PHYSICAL BODY, YOGA EVENTUALLY INFLUENCES ALL ASPECTS OF THE PERSON: VITAL, MENTAL, EMOTIONAL, INTELLECTUAL AND SPIRITUAL. IT OFFERS VARIOUS LEVELS AND APPROACHES TO RELAX, ENERGIZE, REMODEL AND STRENGTHEN BODY AND PSYCHE. THE ASANAS AND PRANAYAMA HARMONIZE THE PHYSIOLOGICAL SYSTEM AND INITIATE A "RELAXATION RESPONSE" IN THE NEURO ENDOCRINAL SYSTEM. THIS CONSISTS OF DECREASED METABOLISM, QUIETER BREATHING, STABLE BLOOD PRESSURE, REDUCED MUSCLE TENSION, LOWER HEART RATE AND SLOW BRAIN WAVE PATTERN. AS THE NEURAL DISCHARGE PATTERN GETS MODULATED, HYPER AROUSAL OF THE NERVOUS SYSTEM AND THE STATIC LOAD ON POSTURAL MUSCLE COME DOWN. THE FUNCTION OF VISCERA IMPROVES WITH THE SENSE OF RELAXATION AND SLEEP GETS DEEPER AND SUSTAINED; FATIGUE DIMINISHES. SEVERAL SUBTLE LEVEL NOTIONAL CORRECTIONS CAN HAPPEN IN CASE THE SUBJECT MEDITATES AND THAT CHANGES THE CONTEXT OF THE DISEASE, PAIN AND THE MEANING OF LIFE. MEDITATION AND PRANAYAMA, ALONG WITH RELAXING ASANAS, CAN HELP INDIVIDUALS DEAL WITH THE EMOTIONAL ASPECTS OF CHRONIC PAIN, REDUCE ANXIETY AND DEPRESSION EFFECTIVELY AND IMPROVE THE QUALITY OF LIFE PERCEIVED. 2010 18 1926 31 ROLE OF YOGA IN CANCER PATIENTS: EXPECTATIONS, BENEFITS, AND RISKS: A REVIEW. BACKGROUND: THE DIAGNOSIS AND TREATMENT OF CANCER POSES SEVERE PSYCHOLOGIC DISTRESS THAT IMPACTS FUNCTIONAL QUALITY OF LIFE. WHILE CANCER DIRECTED TREATMENTS ARE DIRECTED PURELY AGAINST TUMOR KILLING, INTERVENTIONS THAT REDUCE TREATMENT RELATED DISTRESS AND IMPROVE QUALITY OF LIFE ARE THE NEED OF THE HOUR. YOGA IS ONE SUCH MIND BODY INTERVENTION THAT IS GAINING POPULARITY AMONG CANCER PATIENTS. METHOD: SEVERAL RESEARCH STUDIES IN THE LAST TWO DECADES UNRAVEL THE BENEFITS OF YOGA IN TERMS OF IMPROVED MOOD STATES, SYMPTOM REDUCTION, STRESS REDUCTION AND IMPROVED QUALITY OF LIFE APART FROM IMPROVING HOST FACTORS THAT ARE KNOWN TO AFFECT SURVIVAL IN CANCER PATIENTS. HOWEVER, SEVERAL METAANALYSIS AND REVIEWS SHOW EQUIVOCAL BENEFITS FOR YOGA. IN THIS REVIEW, WE WILL STUDY THE YOGA INTERVENTIONS IN CANCER PATIENTS WITH RESPECT TO EXPECTATIONS, BENEFITS AND RISKS AND ANALYSE THE PRINCIPLES BEHIND TAILORING YOGA INTERVENTIONS IN CANCER PATIENTS. RESULTS: THE STUDIES ON YOGA SHOW HETEROGENEITY WITH VARIED TYPES OF YOGA INTERVENTIONS, DURATION, EXPOSURE, PRACTICES AND INDICATIONS. IT ALSO ELUCIDATES THE SITUATIONAL CONTEXT FOR REAPING BENEFITS AND CAUTIONS AGAINST ITS USE IN SEVERAL OTHERS. HOWEVER, THERE ARE SEVERAL REVIEWS AND BIBLIOMETRIC ANALYSIS OF EFFECTS OF YOGA; MOST OF THEM HAVE NOT ENLARGED THE SCOPE OF THEIR REVIEW TO COVER THE BASIC PRINCIPLES BEHIND USE OF THESE PRACTICES IN CANCER PATIENTS. CONCLUSION: THIS REVIEW OFFERS INSIGHT INTO THE PRINCIPLES AND PRACTICE OF YOGA IN CANCER PATIENTS. 2017 19 2516 23 YOGA CLINICAL RESEARCH REVIEW. IN THIS PAPER RECENT RESEARCH IS REVIEWED ON THE EFFECTS OF YOGA POSES ON PSYCHOLOGICAL CONDITIONS INCLUDING ANXIETY AND DEPRESSION, ON PAIN SYNDROMES, CARDIOVASCULAR, AUTOIMMUNE AND IMMUNE CONDITIONS AND ON PREGNANCY. FURTHER, THE PHYSIOLOGICAL EFFECTS OF YOGA INCLUDING DECREASED HEARTRATE AND BLOOD PRESSURE AND THE PHYSICAL EFFECTS INCLUDING WEIGHT LOSS AND INCREASED MUSCLE STRENGTH ARE REVIEWED. FINALLY, POTENTIAL UNDERLYING MECHANISMS ARE PROPOSED INCLUDING THE STIMULATION OF PRESSURE RECEPTORS LEADING TO ENHANCED VAGAL ACTIVITY AND REDUCED CORTISOL. THE REDUCTION IN CORTISOL, IN TURN, MAY CONTRIBUTE TO POSITIVE EFFECTS SUCH AS ENHANCED IMMUNE FUNCTION AND A LOWER PREMATURITY RATE. 2011 20 1561 28 LONGEVITY: POTENTIAL LIFE SPAN AND HEALTH SPAN ENHANCEMENT THROUGH PRACTICE OF THE BASIC YOGA MEDITATION REGIMEN. THIS CHAPTER BRIEFLY REVIEWS RECENT PSYCHOLOGICAL, PHYSIOLOGICAL, MOLECULAR BIOLOGICAL, AND ANTHROPOLOGICAL RESEARCH WHICH HAS IMPORTANT IMPLICATIONS, BOTH DIRECT AND INDIRECT, FOR THE RECOGNITION AND UNDERSTANDING OF THE POTENTIAL LIFE SPAN AND HEALTH SPAN ENHANCING EFFECTS OF THE BASIC YOGA MEDITATIONAL REGIMEN. THIS REGIMEN CONSISTS OF MEDITATION, YOGIC BREATH CONTROL PRACTICES, PHYSICAL EXERCISES (OF BOTH A POSTURAL- AND MOVEMENT-BASED, INCLUDING AEROBIC NATURE), AND DIETARY PRACTICES. WHILE EACH OF THESE COMPONENT CATEGORIES EXHIBIT VARIATIONS IN DIFFERENT SCHOOLS, LINEAGES, TRADITIONS, AND CULTURES, THE FOCUS OF THIS CHAPTER IS PRIMARILY ON BASIC FORMS OF RELAXATION MEDITATION AND BREATH CONTROL, AS WELL AS POSTURAL AND AEROBIC PHYSICAL EXERCISES (E.G., YOGIC PROSTRATION REGIMENS, SEE BELOW), AND A STANDARD FORM OF YOGIC OR ASCETIC DIET, ALL OF WHICH CONSTITUTE A BASIC FORM OF REGIMEN FOUND IN MANY IF NOT MOST CULTURES, THOUGH WITH VARIATIONS. 2009