1  873 103 EFFECT OF YOGA THERAPY ON HEART RATE, BLOOD PRESSURE AND CARDIAC AUTONOMIC FUNCTION IN HEART FAILURE. BACKGROUND AND OBJECTIVE: IT IS WELL KNOWN THAT A HALL MARK OF HEART FAILURE IS ADVERSE CHANGES IN AUTONOMIC FUNCTION. ELEVATED BLOOD PRESSURE IS A POWERFUL PREDICTOR OF CONGESTIVE HEART FAILURE AND OTHER CARDIOVASCULAR DISEASE (CVD) OUTCOMES. IN THIS STUDY, WE PLANNED TO EXAMINE THE EFFECTS OF A 12 WEEK YOGA THERAPY ON BLOOD PRESSURE, HEART RATE, HEART RATE VARIABILITY, AND RATE PRESSURE PRODUCT (RPP). METHODS: OUT OF 130 HEART FAILURE PATIENTS RECRUITED FOR THE STUDY, 65 PATIENTS WERE RANDOMLY SELECTED TO RECEIVE 12 WEEK YOGA THERAPY ALONG WITH STANDARD MEDICAL THERAPY (YOGA GROUP). OTHER PATIENTS (N=65) RECEIVED ONLY STANDARD MEDICAL THERAPY (CONTROL GROUP). HEART RATE, BLOOD PRESSURE, CARDIAC AUTONOMIC FUNCTION (BY SHORT-TERM HEART-RATE VARIABILITY ANALYSIS) AND MYOCARDIAL OXYGEN CONSUMPTION (BY RPP) WERE ASSESSED BEFORE AND AFTER 12 WEEKS. IN THE YOGA GROUP, 44 PATIENTS AND IN THE CONTROL GROUP, 48 PATIENTS COMPLETED THE STUDY. RESULTS: THERE WAS A SIGNIFICANT DECREASE IN HEART RATE, BLOOD PRESSURE AND RPP IN YOGA GROUP COMPARED TO CONTROL GROUP. ALSO, LFNU AND LF-HF RATIO DECREASED SIGNIFICANTLY AND HFNU INCREASED SIGNIFICANTLY IN YOGA GROUP COMPARED TO CONTROL GROUP. CONCLUSION: TWELVE-WEEK YOGA THERAPY SIGNIFICANTLY IMPROVED THE PARASYMPATHETIC ACTIVITY AND DECREASED THE SYMPATHETIC ACTIVITY IN HEART FAILURE PATIENTS (NYHA I&II).	2014	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
2  939  56 EFFECTS OF 12 WEEKS PRACTICE OF YOGA ON HEART RATE VARIABILITY IN MALES WITH TYPE 2 DIABETES RECEIVING ORAL ANTIDIABETIC DRUGS: A RANDOMIZED CONTROL TRIAL. OBJECTIVE: TO INVESTIGATE THE EFFECTS OF 12 WEEKS PRACTICE OF A STRUCTURED YOGA MODULE ON HEART RATE VARIABILITY (HRV) AND CARDIOMETABOLIC RISKS IN PATIENTS WITH TYPE 2 DIABETES (T2D) RECEIVING SIMILAR KIND OF ORAL ANTIDIABETIC DRUGS (OAD) WITH YOGA THERAPY AND WITHOUT YOGA THERAPY, MATCHED FOR ALL THE KNOWN CONFOUNDERS. DESIGN: PARALLEL DESIGN INTERVENTIONAL (RANDOMIZED CONTROL TRIAL) STUDY. SUBJECTS: EIGHTY TREATMENT-NAIVE MALES WITH T2D WERE RANDOMIZED INTO CONTROL GROUP (N = 40) AND STUDY GROUP (N = 40). INTERVENTION: STUDY GROUP PARTICIPANTS RECEIVED A STRUCTURED YOGA THERAPY THAT INCLUDED ASANA AND PRANAYAMA PRACTICE FOR 12 WEEKS IN ADDITION TO OAD, WHEREAS CONTROL GROUP PARTICIPANTS RECEIVED OAD ALONE. OUTCOME MEASURES: BEFORE AND AFTER INTERVENTION, BP PARAMETERS, RATE PRESSURE PRODUCT (RPP) AS THE MARKER OF MYOCARDIAL STRESS, TOTAL POWER (TP) OF HRV, LOW-FREQUENCY TO HIGH-FREQUENCY (LF-HF) RATIO OF HRV, HOMEOSTATIC MODEL OF INSULIN RESISTANCE (HOMA-IR), LIPID PROFILE AND LIPID RISK FACTORS, MALONDIALDEHYDE (MDA), AND HIGH-SENSITIVE C-REACTIVE PROTEIN (HSCRP) WERE MEASURED. TP OF HRV WAS DEFINED AS THE PRIMARY OUTCOME. ASSOCIATION OF TP (THE MARKER OF HRV) AND LF-HF RATIO (THE MARKER OF SYMPATHOVAGAL BALANCE) WITH CARDIOMETABOLIC PARAMETERS WAS ASSESSED BY CORRELATION AND REGRESSION ANALYSES. RESULTS: AFTER 12 WEEKS YOGA THERAPY, THERE WAS SIGNIFICANT REDUCTION IN CARDIOMETABOLIC RISKS (TP OF HRV, RPP, LIPID RISKS FACTORS, LEVELS OF MDA, AND HSCRP) IN STUDY GROUP SUBJECTS COMPARED WITH CONTROL SUBJECTS THAT DID NOT RECEIVE YOGA THERAPY. ALL CARDIOMETABOLIC RISK FACTORS WERE SIGNIFICANTLY CORRELATED WITH TP IN STUDY GROUP, HAVING MAXIMUM SIGNIFICANCE WITH HOMEOSTATIC MODEL OF INSULIN SECRETION (R = 0.502, P </= 0.001). MULTIPLE REGRESSION ANALYSIS DEMONSTRATED THE INDEPENDENT CONTRIBUTION OF DECREASE IN RPP, HOMA-IR, HSCRP, AND MDA TO INCREASED TP AND DECREASED LF-HF RATIO IN T2D PATIENTS AFTER YOGA THERAPY. CONCLUSION: FROM THE RESULTS OF THIS STUDY, THE AUTHORS CONCLUDE THAT 12 WEEKS PRACTICE OF A STRUCTURED YOGA MODULE IMPROVES TP OF HRV, SYMPATHOVAGAL BALANCE, AND METABOLIC FUNCTIONS, AND REDUCE CARDIOVASCULAR (CV) RISKS IN PATIENTS WITH DIABETES WHO RECEIVED ROUTINE ANTIDIABETIC MEDICINES ALONG WITH YOGA THERAPY, COMPARED WITH THE PATIENTS WITH DIABETES WHO RECEIVED ANTIDIABETIC MEDICINES ALONE. THE REDUCTION IN CARDIOMETABOLIC RISKS IN THESE PATIENTS IS LINKED TO THE IMPROVEMENT IN TP OF HRV. FUTURE STUDIES SHOULD ALSO INCLUDE A CONTROL GROUP WITH RAPID WALKING OR A SIMILAR EXERCISE PROGRAM OF EQUAL TIME TO THE YOGA INTERVENTION GROUP TO DISCERN WHETHER IT IS IN FACT YOGA THAT IS LEADING TO THESE RESULTS AND NOT SIMPLY INCREASED CV ACTIVITY. CLINICAL TRIAL REGISTRY OF INDIA (NO. CTRI/2021/06/034074).	2021	

3 1027  39 EFFECTS OF YOGA BREATHING PRACTICE ON HEART RATE VARIABILITY IN HEALTHY ADOLESCENTS: A RANDOMIZED CONTROLLED TRIAL. BACKGROUND: THIS STUDY WAS CONDUCTED AMONG HEALTHY ADOLESCENTS TO ASSESS THE EFFECTS OF A YOGA BREATHING PRACTICE (BHRAMARI PRANAYAMA, BHR.P) TOWARDS CARDIAC AUTONOMIC FUNCTION USING HEART RATE VARIABILITY (HRV) PARAMETERS. METHODS: OF THE 730 ELIGIBLE SUBJECTS SCREENED, 520 HEALTHY ADOLESCENTS WHO MET THE INCLUSION AND EXCLUSION CRITERIA WERE RANDOMLY ASSIGNED TO EITHER YOGA BREATHING GROUP (N=260) OR CONTROL GROUP (N=260). THE YOGA BREATHING GROUP PRACTICED BHR.P. FIVE DAYS A WEEK FOR A DURATION OF SIX MONTHS WHILE THE CONTROL GROUP CONTINUED WITH THEIR DAILY ROUTINE WITHOUT ANY INTERVENTION. OUTCOME MEASURES WERE TIME AND FREQUENCY DOMAIN OF HRV IN BOTH GROUPS WHICH WERE ASSESSED BEFORE AND AFTER THE INTERVENTION USING LEAD II ECG. LINEAR MODELS WERE USED IN THE ANALYSIS OF SHORT TERM HRV. RESULTS: AFTER 6 MONTHS OF YOGA BREATHING, THE TIME DOMAIN PARAMETERS OF SHORT TERM HRV SHOWED SIGNIFICANT (P<0.05) IMPROVEMENT TOWARDS THE PARASYMPATHETIC DOMAIN. FREQUENCY DOMAIN PARAMETERS ALSO SHOWED THE SAME DIRECTION OF CHANGES. IN CONTRAST, CONTROL GROUP SUBJECTS SHOWED A TREND TOWARDS A SYMPATHETIC DOMAIN. CONCLUSION: THE PRESENT STUDY SHOWED A POSITIVE SHIFT IN CARDIAC AUTONOMIC MODULATION TOWARDS PARASYMPATHETIC PREDOMINANCE AFTER 6 MONTHS OF YOGA BREATHING PRACTICE AMONG APPARENTLY HEALTHY ADOLESCENTS.	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
4  871  54 EFFECT OF YOGA THERAPY ON DISEASE ACTIVITY, INFLAMMATORY MARKERS, AND HEART RATE VARIABILITY IN PATIENTS WITH RHEUMATOID ARTHRITIS. BACKGROUND: RHEUMATOID ARTHRITIS (RA) IS AN IMMUNE-MEDIATED INFLAMMATORY DISEASE. ANTIRHEUMATOID TREATMENT REDUCES DISEASE ACTIVITY AND INFLAMMATION, BUT NOT ALL PATIENTS RESPOND TO TREATMENT. AUTONOMIC DYSFUNCTION IS COMMON IN RA LEADING TO FREQUENT CARDIOVASCULAR COMPLICATIONS. YOGA THERAPY MAY BE USEFUL IN THESE PATIENTS, BUT THERE ARE LITTLE DATA ON THE EFFECT OF YOGA ON DISEASE ACTIVITY, INFLAMMATORY MARKERS, AND HEART RATE VARIABILITY (HRV). OBJECTIVES: THIS STUDY ASSESSED THE EFFECT OF 12-WEEK YOGA THERAPY ON DISEASE ACTIVITY, INFLAMMATORY MARKERS, AND HRV IN PATIENTS WITH RA. MATERIALS AND METHODS: THIS RANDOMIZED CONTROL TRIAL WAS CONDUCTED ON NEWLY DIAGNOSED RA PATIENTS ATTENDING OUTPATIENT SERVICES AT THE DEPARTMENT OF CLINICAL IMMUNOLOGY, JIPMER. ONE HUNDRED AND SIXTY-SIX PARTICIPANTS WERE RANDOMIZED INTO TWO GROUPS: THE CONTROL GROUP (CG) (N = 83) AND YOGA GROUP (YG) (N = 83). YOGA THERAPY WAS ADMINISTERED TO PARTICIPANTS IN THE YG FOR 12 WEEKS, ALONG WITH STANDARD MEDICAL TREATMENT. THE CG RECEIVED ONLY STANDARD MEDICAL TREATMENT. PRIMARY OUTCOMES WERE DISEASE ACTIVITY SCORE 28, INTERLEUKIN-1ALPHA (IL-1ALPHA), IL-6, TUMOR NECROSIS FACTOR-ALPHA (TNF-ALPHA), CORTISOL, AND HRV PARAMETERS. ALL PARAMETERS WERE MEASURED AT BASELINE AND AFTER 12 WEEKS. RESULTS: DISEASE ACTIVITY SIGNIFICANTLY DECREASED IN BOTH GROUPS AFTER 12 WEEKS, BUT IT WAS REDUCED MORE IN YG, WHICH WAS STATISTICALLY SIGNIFICANT (P < 0.05). IN BOTH YG AND CG, IL-1ALPHA, IL-6, TNF-ALPHA, AND CORTISOL DECREASED AFTER 12 WEEKS, BUT IL-1ALPHA AND CORTISOL DECREASED MORE SIGNIFICANTLY IN YG THAN IN CG. LOW-FREQUENCY COMPONENT EXPRESSED AS NORMALIZED UNIT (LFNU) AND THE LOW-FREQUENCY/HIGH-FREQUENCY (LF-HF) RATIO DECREASED SIGNIFICANTLY, AND TOTAL POWER AND HF COMPONENT EXPRESSED AS NORMALIZED UNIT (HFNU) INCREASED SIGNIFICANTLY IN THE YG COMPARED WITH CG. CONCLUSION: TWELVE-WEEK YOGA THERAPY, IF GIVEN ALONG WITH STANDARD MEDICAL TREATMENT, SIGNIFICANTLY REDUCES DISEASE ACTIVITY AND IMPROVES SYMPATHOVAGAL BALANCE IN RA PATIENTS.	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
5 2817  39 YOGA TRAINING IMPROVES QUALITY OF LIFE IN WOMEN WITH ASTHMA. OBJECTIVES: INDIVIDUALS WITH ASTHMA FREQUENTLY SUFFER WITH A DECREASE IN QUALITY OF LIFE. YOGA HAS BEEN SHOWN TO IMPROVE AUTONOMIC FUNCTION IN THE HEALTHY POPULATION AND HAS BEEN USED AS AN ALTERNATIVE THERAPY TO HELP IMPROVE SYMPTOMS ASSOCIATED WITH VARIOUS DISEASES. PURPOSE: THE PURPOSE OF THIS STUDY WAS TO ASSESS WHETHER 10 WEEKS OF YOGA TRAINING CAN IMPROVE QUALITY OF LIFE AND HEART RATE VARIABILITY (HRV) IN PATIENTS WITH ASTHMA. DESIGN: NINETEEN (19) FEMALES WERE RANDOMLY ASSIGNED TO A YOGA GROUP OR A CONTROL GROUP FOR A 10-WEEK INTERVENTION WHILE STILL FOLLOWING GUIDELINES ESTABLISHED BY THEIR PHYSICIAN. ALL SUBJECTS ANSWERED THE ST. GEORGE'S RESPIRATORY QUESTIONNAIRE (SGRQ) TO ASSESS QUALITY OF LIFE AND PERFORMED AN ISOMETRIC HANDGRIP EXERCISE TEST TO ASSESS HRV. RESULTS: BASED ON THE SGRQ, SIGNIFICANT IMPROVEMENTS (45%, P < 0.05) IN QUALITY OF LIFE WERE OBSERVED WITH THE YOGA TRAINING, WHILE NO CHANGES WERE FOUND IN THE CONTROL GROUP. RESTING HEMODYNAMIC MEASURES IMPROVED SIGNIFICANTLY IN THE YOGA GROUP COMPARED TO THE CONTROL GROUP (P < 0.05). THE YOGA GROUP DECREASED PARASYMPATHETIC MODULATION (HFNU [NORMALIZED UNITS]) PRE- TO POSTINTERVENTION (0.45 +/- 0.60 TO 0.35 +/- 0.06 NU, P<0.05, RESPECTIVELY) IN RESPONSE TO THE ISOMETRIC FOREARM EXERCISE (IFE), WHEREAS THE CONTROL GROUP DID NOT CHANGE. ADDITIONALLY, THE YOGA GROUP INCREASED SYMPATHETIC (LFNU) (PRE 0.47 +/- 0.07 TO POST 0.60 +/- 0.07 NU, P < 0.05) AND SYMPATHOVAGAL MODULATION (LOGLF/HF) (PRE 4.61 +/- 0.39 TO POST 5.31 +/- 0.44, P < 0.05, RESPECTIVELY) DURING IFE WITH NO CHANGE IN THE CONTROL GROUP. CONCLUSIONS: YOGA TRAINING IMPROVED QUALITY OF LIFE IN WOMEN WITH MILD-TO-MODERATE ASTHMA AND RESULTED IN DECREASED PARASYMPATHETIC AND INCREASED SYMPATHETIC MODULATION IN RESPONSE TO AN IFE.	2012	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
6 1638  31 MODULATION OF CARDIOVASCULAR RESPONSE TO EXERCISE BY YOGA TRAINING. THIS STUDY REPORTS THE EFFECTS OF YOGA TRAINING ON CARDIOVASCULAR RESPONSE TO EXERCISE AND THE TIME COURSE OF RECOVERY AFTER THE EXERCISE. CARDIOVASCULAR RESPONSE TO EXERCISE WAS DETERMINED BY HARVARD STEP TEST USING A PLATFORM OF 45 CM HEIGHT. THE SUBJECTS WERE ASKED TO STEP UP AND DOWN THE PLATFORM AT A RATE OF 30/MIN FOR A TOTAL DURATION OF 5 MIN OR UNTIL FATIGUE, WHICHEVER WAS EARLIER. HEART RATE (HR) AND BLOOD PRESSURE RESPONSE TO EXERCISE WERE MEASURED IN SUPINE POSITION BEFORE EXERCISE AND AT 1, 2, 3, 4, 5, 7 AND 10 MINUTES AFTER THE EXERCISE. RATE-PRESSURE PRODUCT [RPP = (HR X SP)/100] AND DOUBLE PRODUCT (DO P = HR X MP), WHICH ARE INDICES OF WORK DONE BY THE HEART WERE ALSO CALCULATED. EXERCISE PRODUCED A SIGNIFICANT INCREASE IN HR, SYSTOLIC PRESSURE, RPP & DOP AND A SIGNIFICANT DECREASE IN DIASTOLIC PRESSURE. AFTER TWO MONTHS OF YOGA TRAINING, EXERCISE-INDUCED CHANGES IN THESE PARAMETERS WERE SIGNIFICANTLY REDUCED. IT IS CONCLUDED THAT AFTER YOGA TRAINING A GIVEN LEVEL OF EXERCISE LEADS TO A MILDER CARDIOVASCULAR RESPONSE, SUGGESTING BETTER EXERCISE TOLERANCE.	2004	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
7 2775  40 YOGA RESPIRATORY TRAINING IMPROVES RESPIRATORY FUNCTION AND CARDIAC SYMPATHOVAGAL BALANCE IN ELDERLY SUBJECTS: A RANDOMISED CONTROLLED TRIAL. OBJECTIVES: SINCE AGEING IS ASSOCIATED WITH A DECLINE IN PULMONARY FUNCTION, HEART RATE VARIABILITY AND SPONTANEOUS BAROREFLEX, AND RECENT STUDIES SUGGEST THAT YOGA RESPIRATORY EXERCISES MAY IMPROVE RESPIRATORY AND CARDIOVASCULAR FUNCTION, WE HYPOTHESISED THAT YOGA RESPIRATORY TRAINING MAY IMPROVE RESPIRATORY FUNCTION AND CARDIAC AUTONOMIC MODULATION IN HEALTHY ELDERLY SUBJECTS. DESIGN: 76 HEALTHY ELDERLY SUBJECTS WERE ENROLLED IN A RANDOMISED CONTROL TRIAL IN BRAZIL AND 29 COMPLETED THE STUDY (AGE 68 +/- 6 YEARS, 34% MALES, BODY MASS INDEX 25 +/- 3 KG/M(2)). SUBJECTS WERE RANDOMISED INTO A 4-MONTH TRAINING PROGRAM (2 CLASSES/WEEK PLUS HOME EXERCISES) OF EITHER STRETCHING (CONTROL, N=14) OR RESPIRATORY EXERCISES (YOGA, N=15). YOGA RESPIRATORY EXERCISES (BHASTRIKA) CONSISTED OF RAPID FORCED EXPIRATIONS FOLLOWED BY INSPIRATION THROUGH THE RIGHT NOSTRIL, INSPIRATORY APNOEA WITH GENERATION OF INTRATHORACIC NEGATIVE PRESSURE, AND EXPIRATION THROUGH THE LEFT NOSTRIL. PULMONARY FUNCTION, MAXIMUM EXPIRATORY AND INSPIRATORY PRESSURES (PE(MAX) AND PI(MAX), RESPECTIVELY), HEART RATE VARIABILITY AND BLOOD PRESSURE VARIABILITY FOR SPONTANEOUS BAROREFLEX DETERMINATION WERE DETERMINED AT BASELINE AND AFTER 4 MONTHS. RESULTS: SUBJECTS IN BOTH GROUPS HAD SIMILAR DEMOGRAPHIC PARAMETERS. PHYSIOLOGICAL VARIABLES DID NOT CHANGE AFTER 4 MONTHS IN THE CONTROL GROUP. HOWEVER, IN THE YOGA GROUP, THERE WERE SIGNIFICANT INCREASES IN PE(MAX) (34%, P<0.0001) AND PI(MAX) (26%, P<0.0001) AND A SIGNIFICANT DECREASE IN THE LOW FREQUENCY COMPONENT (A MARKER OF CARDIAC SYMPATHETIC MODULATION) AND LOW FREQUENCY/HIGH FREQUENCY RATIO (MARKER OF SYMPATHOVAGAL BALANCE) OF HEART RATE VARIABILITY (40%, P<0.001). SPONTANEOUS BAROREFLEX DID NOT CHANGE, AND QUALITY OF LIFE ONLY MARGINALLY INCREASED IN THE YOGA GROUP. CONCLUSION: RESPIRATORY YOGA TRAINING MAY BE BENEFICIAL FOR THE ELDERLY HEALTHY POPULATION BY IMPROVING RESPIRATORY FUNCTION AND SYMPATHOVAGAL BALANCE. TRIAL REGISTRATION CINICALTRIALS.GOV IDENTIFIER: NCT00969345; TRIAL REGISTRY NAME: EFFECTS OF RESPIRATORY YOGA TRAINING (BHASTRIKA) ON HEART RATE VARIABILITY AND BAROREFLEX, AND QUALITY OF LIFE OF HEALTHY ELDERLY SUBJECTS.	2011	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
8  705  39 EFFECT OF INTEGRATED APPROACH OF YOGA THERAPY ON AUTONOMIC FUNCTIONS IN PATIENTS WITH TYPE 2 DIABETES. BACKGROUND AND OBJECTIVES: INTEGRATED APPROACH OF YOGA THERAPY (IAYT) HAD SHOWN BENEFICIAL EFFECTS IN THE MANAGEMENT OF TYPE 2 DIABETES MELLITUS (DM). AUTONOMIC DYSFUNCTION IS ONE OF THE MAJOR COMPLICATIONS OF TYPE 2 DM. RESEARCH STUDIES HAVE DEMONSTRATED THAT YOGA CAN MODULATE AUTONOMIC FUNCTIONS. HENCE, THE CURRENT STUDY WAS DESIGNED TO ASSESS THE EFFECT OF IAYT ON AUTONOMIC FUNCTIONS IN TYPE 2 DIABETICS. MATERIALS AND METHODS: 15 PATIENTS OF TYPE 2 DM WITH AGES RANGING FROM 35 TO 60 YEARS WERE RECRUITED FOR THE STUDY. THEY WERE DIAGNOSED WITH TYPE 2 DIABETES FROM 1-YEAR TO 15 YEARS. ASSESSMENTS WERE MADE ON DAY 1 (BEFORE YOGA) AND DAY 7 (AFTER 1-WEEK OF YOGA PRACTICE). HEART RATE VARIABILITY (HRV), BLOOD PRESSURE (BP) RESPONSE TO THE ISOMETRIC HANDGRIP AND HEART RATE RESPONSE TO DEEP BREATHING WERE ASSESSED BEFORE AND AFTER 1-WEEK OF IAYT. RESULTS: THERE WAS A SIGNIFICANT REDUCTION IN FASTING PLASMA GLUCOSE FROM 154.67-130.27 MG/DL (WILCOXON SIGNED RANK TEST, P = 0.029) FOLLOWING 1-WEEK OF IAYT. BP RESPONSE TO ISOMETRIC HAND GRIP IMPROVED SIGNIFICANTLY (WILCOXON SIGNED RANK TEST, P = 0.01). THERE WAS NO STATISTICAL SIGNIFICANT CHANGE IN HRV COMPONENTS AND HEART RATE RESPONSE TO DEEP BREATHING TEST. HOWEVER, THERE WAS A TREND OF INCREASE IN THE LOW FREQUENCY POWER (41.07%), HIGH FREQUENCY POWER (6.29%), TOTAL POWER (5.38%), AND STANDARD DEVIATION OF ALL NN INTERVALS (SDNN) (6.29%). CONCLUSION: THESE FINDINGS SUGGEST THAT, IAYT IMPROVED AUTONOMIC FUNCTIONS IN TYPE 2 DIABETES PATIENTS.	2015	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
9  297  39 ALTERNATE NOSTRIL BREATHING AT DIFFERENT RATES AND ITS INFLUENCE ON HEART RATE VARIABILITY IN NON PRACTITIONERS OF YOGA. INTRODUCTION: HEART RATE VARIABILITY IS A MEASURE OF MODULATION IN AUTONOMIC INPUT TO THE HEART AND IS ONE OF THE MARKERS OF AUTONOMIC FUNCTIONS. THOUGH THERE ARE MANY STUDIES ON THE LONG TERM INFLUENCE OF BREATHING ON HRV (HEART RATE VARIABILITY) THERE ARE ONLY A FEW STUDIES ON THE IMMEDIATE EFFECT OF BREATHING ESPECIALLY ALTERNATE NOSTRIL BREATHING ON HRV. THIS STUDY FOCUSES ON THE IMMEDIATE EFFECTS OF ALTERNATE NOSTRIL BREATHING AND THE INFLUENCE OF DIFFERENT BREATHING RATES ON HRV. MATERIALS AND METHODS: THE STUDY WAS DONE ON 25 SUBJECTS IN THE AGE GROUP OF 17-35 YEARS. ECG AND RESPIRATION WERE RECORDED BEFORE INTERVENTION AND IMMEDIATELY AFTER THE SUBJECTS WERE ASKED TO PERFORM ALTERNATE NOSTRIL BREATHING FOR FIVE MINUTES. RESULTS: LOW FREQUENCY (LF) WHICH IS A MARKER OF SYMPATHETIC ACTIVITY INCREASED, HIGH FREQUENCY (HF) WHICH IS A MARKER OF PARASYMPATHETIC ACTIVITY DECREASED AND THEIR RATIO LF/HF WHICH IS A MARKER OF SYMPATHO/VAGAL BALANCE INCREASED IMMEDIATELY AFTER 6 AND 12 MINUTES IN COMPARISON TO BASELINE VALUES WHEREAS THERE WAS NO SIGNIFICANT DIFFERENCE IN THE MEANS OF THESE COMPONENTS WHEN BOTH 6 AND 12 MINUTES WERE COMPARED. CONCLUSION: IMMEDIATE EFFECTS OF ALTERNATE NOSTRIL BREATHING ON HRV IN NON PRACTITIONERS OF YOGIC BREATHING ARE VERY DIFFERENT FROM THE LONG TERM INFLUENCE OF YOGIC BREATHING ON HRV WHICH SHOW A PREDOMINANT PARASYMPATHETIC INFLUENCE ON THE HEART.	2016	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
10 1441  43 INCREASED HEART RATE VARIABILITY BUT NO EFFECT ON BLOOD PRESSURE FROM 8 WEEKS OF HATHA YOGA - A PILOT STUDY. BACKGROUND: YOGA EXERCISES ARE KNOWN TO DECREASE STRESS AND RESTORE AUTONOMIC BALANCE. YET KNOWLEDGE ABOUT THE PHYSIOLOGICAL EFFECTS OF INVERSION POSTURES IS LIMITED. THIS STUDY AIMED TO INVESTIGATE THE EFFECTS OF INVERSION POSTURES (HEAD BELOW THE HEART) ON BLOOD PRESSURE (BP) AND HEART RATE VARIABILITY (HRV). METHODS: TWELVE HEALTHY WOMEN AND MEN TOOK PART IN AN 8-WEEK YOGA PROGRAM (60 MIN ONCE A WEEK). BP WAS MEASURED WITH AN AUTOMATIC OMRON MX3 OSCILLOMETRIC MONITORING DEVICE AND HRV WITH A HOLTER 24-HOUR ECG AT BASELINE AND 8 WEEKS AFTER THE INTERVENTION. RESULTS: THERE WAS NO SIGNIFICANT EFFECT OF INVERSION POSTURES ON BP. NINE OUT OF 12 PARTICIPANTS SHOWED A SIGNIFICANT INCREASE IN HRV (P < 0.05) AT NIGHT (2 HOURS) ON PNN50% (12.7 +/- 12.5 TO 18.2 +/- 13.3). THERE WERE NO SIGNIFICANT CHANGES IN OTHER HRV MEASURES SUCH AS NN50, LF, HF, LF/HF RATIO, LF NORMALIZED UNITS (N.U.), HF N.U. AND RMSSD. CONCLUSION: EIGHT WEEKS OF HATHA YOGA IMPROVED HRV SIGNIFICANTLY WHICH SUGGESTS AN INCREASED VAGAL TONE AND REDUCED SYMPATHETIC ACTIVITY.	2013	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
11 2863  32 YOGA-BASED GUIDED RELAXATION REDUCES SYMPATHETIC ACTIVITY JUDGED FROM BASELINE LEVELS. 35 MALE VOLUNTEERS WHOSE AGES RANGED FROM 20 TO 46 YEARS WERE STUDIED IN TWO SESSIONS OF YOGA-BASED GUIDED RELAXATION AND SUPINE REST. ASSESSMENTS OF AUTONOMIC VARIABLES WERE MADE FOR 15 SUBJECTS, BEFORE, DURING, AND AFTER THE PRACTICES, WHEREAS OXYGEN CONSUMPTION AND BREATH VOLUME WERE RECORDED FOR 25 SUBJECTS BEFORE AND AFTER BOTH TYPES OF RELAXATION. A SIGNIFICANT DECREASE IN OXYGEN CONSUMPTION AND INCREASE IN BREATH VOLUME WERE RECORDED AFTER GUIDED RELAXATION (PAIRED T TEST). THERE WERE COMPARABLE REDUCTIONS IN HEART RATE AND SKIN CONDUCTANCE DURING BOTH TYPES OF RELAXATION. DURING GUIDED RELAXATION THE POWER OF THE LOW FREQUENCY COMPONENT OF THE HEART-RATE VARIABILITY SPECTRUM REDUCED, WHEREAS THE POWER OF THE HIGH FREQUENCY COMPONENT INCREASED, SUGGESTING REDUCED SYMPATHETIC ACTIVITY. ALSO, SUBJECTS WITH A BASELINE RATIO OF LF/HF > 0.5 SHOWED A SIGNIFICANT DECREASE IN THE RATIO AFTER GUIDED RELAXATION, WHILE SUBJECTS WITH A RATIO < OR = 0.5 AT BASELINE SHOWED NO SUCH CHANGE. THE RESULTS SUGGEST THAT SYMPATHETIC ACTIVITY DECREASED AFTER GUIDED RELAXATION BASED ON YOGA, DEPENDING ON THE BASELINE LEVELS.	2002	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
12  300  25 AN ASSESSMENT OF A SEQUENCE OF YOGA EXERCISES TO PATIENTS WITH ARTERIAL HYPERTENSION. THIS QUASI-EXPERIMENTAL STUDY DESCRIBES THE EFFECTS OF A YOGA SEQUENCE FOLLOWING HEMODYNAMIC AND BIOCHEMICAL PARAMETERS IN PATIENTS WITH HYPERTENSION. THIRTY-THREE VOLUNTEERS PARTICIPATED IN THE STUDY (CONTROL = 16 AND YOGA = 17) FOR FOUR MONTHS. BLOOD PRESSURE MEASUREMENTS, CARDIAC AND RESPIRATORY RATE WERE COLLECTED MONTHLY, WHILE THE BIOCHEMICAL PROFILE WAS TAKEN AT THE BEGINNING AND END OF THE PROGRAM. TO ANALYZE THE DATA, STUDENT'S T TEST AND REPEATED MEASURES ANALYSES WERE PERFORMED. THE YOGA GROUP SHOWED A SIGNIFICANT REDUCTION OF SYSTOLIC BLOOD PRESSURE, HEART AND RESPIRATORY RATE (P < 0.05). AS FOR THE BIOCHEMICAL PROFILE, THE YOGA GROUP SHOWED CORRELATION COEFFICIENTS BETWEEN INITIAL VALUES AND FINAL RESPONSES GREATER THAN THE CONTROL OF FASTING GLUCOSE, TOTAL CHOLESTEROL, LDL-CHOLESTEROL AND TRIGLYCERIDES. THE ELABORATED SEQUENCE PRACTICE PROMOTED SIGNIFICANT CARDIOVASCULAR AND METABOLIC BENEFITS. THE YOGA EXERCISES PERFORMED IN THE PROPOSED SEQUENCE CONSTITUTE COMPLEMENTARY NON-PHARMACOLOGICAL CONTROL OF BLOOD PRESSURE IN PATIENTS WITH HYPERTENSION.	2013	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
13  452  38 CHANGES IN HEART RATE VARIABILITY AFTER YOGA ARE DEPENDENT ON HEART RATE VARIABILITY AT BASELINE AND DURING YOGA: A STUDY SHOWING AUTONOMIC NORMALIZATION EFFECT IN YOGA-NAIVE AND EXPERIENCED SUBJECTS. BACKGROUND: YOGA THERAPY IS WIDELY APPLIED TO THE MAINTENANCE OF HEALTH AND TO TREATMENT OF VARIOUS ILLNESSES. PREVIOUS RESEARCHES INDICATE THE INVOLVEMENT OF AUTONOMIC CONTROL IN ITS EFFECTS, ALTHOUGH THE GENERAL AGREEMENT HAS NOT BEEN REACHED REGARDING THE ACUTE MODULATION OF AUTONOMIC FUNCTION. AIM: THE PRESENT STUDY AIMED AT REVEALING THE ACUTE EFFECT OF YOGA ON THE AUTONOMIC ACTIVITY USING HEART RATE VARIABILITY (HRV) MEASUREMENT. METHODS: TWENTY-SEVEN HEALTHY CONTROLS PARTICIPATED IN THE PRESENT STUDY. FIFTEEN OF THEM (39.5 +/- 8.5 YEARS OLD) WERE NAIVE AND 12 (45.1 +/- 7.0 YEARS OLD) WERE EXPERIENCED IN YOGA. YOGA SKILLS INCLUDED BREATH AWARENESS, TWO TYPES OF ASANA, AND TWO TYPES OF PRANAYAMA. HRV WAS MEASURED AT THE BASELINE, DURING YOGA, AND AT THE RESTING STATE AFTER YOGA. RESULTS: IN BOTH YOGA-NAIVE AND EXPERIENCED PARTICIPANTS, THE CHANGES IN LOW-FREQUENCY (LF) COMPONENT OF HRV AND ITS RATIO TO HIGH-FREQUENCY (HF) COMPONENT (LF/HF) AFTER YOGA WERE FOUND TO BE CORRELATED NEGATIVELY WITH THE BASELINE DATA. THE CHANGES IN LF AFTER YOGA WERE ALSO CORRELATED WITH LF DURING YOGA. THE CHANGES IN HF AS WELL AS THE RAW HRV DATA AFTER YOGA WERE NOT RELATED TO THE BASELINE HRV OR THE HRV DURING YOGA. CONCLUSION: THE RESULTS INDICATE THAT YOGA LEADS TO AN INCREASE IN LF WHEN LF IS LOW AND LEADS TO A DECREASE IN LF WHEN IT IS HIGH AT THE BASELINE. THIS NORMALIZATION OF LF IS DEPENDENT ON THE AUTONOMIC MODULATION DURING YOGA AND MAY UNDERLIE THE CLINICAL EFFECTIVENESS OF YOGA THERAPY BOTH IN YOGA-NAIVE AND EXPERIENCED SUBJECTS.	2020	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
14 1318  40 HEART RATE VARIABILITY IN CHRONIC LOW BACK PAIN PATIENTS RANDOMIZED TO YOGA OR STANDARD CARE. BACKGROUND: CHRONIC PAIN CAN ALTER THE AUTONOMIC BALANCE WITH INCREASED SYMPATHETIC ACTIVITY REFLECTED IN ALTERED HEART RATE VARIABILITY (HRV). IT HAS BEEN PROPOSED THAT YOGA CAN BE USEFUL TO CORRECT THE AUTONOMIC IMBALANCE IN PATIENTS WITH CHRONIC PAIN WHO HAVE REDUCED HRV. METHODS AND DESIGNS: IN THE PRESENT RANDOMIZED CONTROLLED TRIAL 62 PATIENTS WITH CHRONIC LOW BACK PAIN ASSOCIATED WITH ALTERED ALIGNMENT OF INTERVERTEBRAL DISCS (AGED BETWEEN 20 AND 45 YEARS, 32 MALES) WERE RANDOMIZED TO 2 GROUPS. ONE GROUP RECEIVED YOGA FOR 3 MONTHS WHILE THE OTHER GROUP CARRIED OUT STANDARD MEDICAL CARE BASED ON THE PHYSICIAN'S ADVICE. THE DURATION WAS THE SAME, I.E., 3 MONTHS. THE HEART RATE VARIABILITY AND RATE OF RESPIRATION WERE ASSESSED AT BASELINE AND AT THE END OF 3 MONTHS. RESULTS: THERE WAS A SIGNIFICANT DIFFERENCE IN THE BASELINE (PRE) VALUES BETWEEN GROUPS (P = 0.008) FOR RESPIRATION RATE WHICH WAS HIGHER IN THE YOGA GROUP. THE CHANGES REPORTED BELOW ARE PRE-POST COMPARISONS WITHIN EACH GROUP. THE YOGA GROUP SHOWED A SIGNIFICANT (P < 0.05; REPEATED MEASURES ANOVA, POST-HOC ANALYSES) DECREASE IN THE LF POWER OF HRV, RATE OF RESPIRATION AND A SIGNIFICANT INCREASE IN THE HF POWER OF HRV AND IN THE PNN50. CONCLUSION: THE RESULTS SUGGEST THAT YOGA PRACTICE CAN SHIFT THE AUTONOMIC BALANCE TOWARDS VAGAL DOMINANCE IN PATIENTS WITH CHRONIC LOW BACK PAIN ASSOCIATED WITH ALTERED ALIGNMENT OF INTERVERTEBRAL DISCS. TRIAL REGISTRATION: THE STUDY IS REGISTERED WITH THE CLINICAL TRIALS REGISTRY OF INDIA ( CTRI/2012/11/003094 ) AND CAN BE ACCESSED AT.	2016	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
15 1637  33 MODULATION OF CARDIAC AUTONOMIC BALANCE WITH ADJUVANT YOGA THERAPY IN PATIENTS WITH REFRACTORY EPILEPSY. THE PRACTICE OF YOGA REGULATES BODY PHYSIOLOGY THROUGH CONTROL OF POSTURE, BREATHING, AND MEDITATION. EFFECTS OF YOGA ON AUTONOMIC FUNCTIONS OF PATIENTS WITH REFRACTORY EPILEPSY, AS QUANTIFIED BY STANDARDIZED AUTONOMIC FUNCTION TESTS (AFTS), WERE DETERMINED. THE YOGA GROUP (N=18) RECEIVED SUPERVISED TRAINING IN YOGA, AND THE EXERCISE GROUP (N=16) PRACTICED SIMPLE ROUTINE EXERCISES. AFTS WERE REPEATED AFTER 10 WEEKS OF DAILY SESSIONS. DATA WERE COMPARED WITH THOSE OF HEALTHY VOLUNTEERS (N=142). THE YOGA GROUP SHOWED SIGNIFICANT IMPROVEMENT IN PARASYMPATHETIC PARAMETERS AND A DECREASE IN SEIZURE FREQUENCY SCORES. THERE WAS NO IMPROVEMENT IN BLOOD PRESSURE PARAMETERS IN EITHER GROUP. TWO PATIENTS IN THE YOGA GROUP ACHIEVED NORMAL AUTONOMIC FUNCTIONS AT THE END OF 10 WEEKS OF THERAPY, WHEREAS THERE WERE NO CHANGES IN THE EXERCISE GROUP. THE DATA SUGGEST THAT YOGA MAY HAVE A ROLE AS AN ADJUVANT THERAPY IN THE MANAGEMENT OF AUTONOMIC DYSFUNCTION IN PATIENTS WITH REFRACTORY EPILEPSY.	2008	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
16 1530  36 IYENGAR YOGA INCREASES CARDIAC PARASYMPATHETIC NERVOUS MODULATION AMONG HEALTHY YOGA PRACTITIONERS. RELAXATION TECHNIQUES ARE ESTABLISHED IN MANAGING OF CARDIAC PATIENTS DURING REHABILITATION AIMING TO REDUCE FUTURE ADVERSE CARDIAC EVENTS. IT HAS BEEN HYPOTHESIZED THAT RELAXATION-TRAINING PROGRAMS MAY SIGNIFICANTLY IMPROVE CARDIAC AUTONOMIC NERVOUS TONE. HOWEVER, THIS HAS NOT BEEN PROVEN FOR ALL AVAILABLE RELAXATION TECHNIQUES. WE TESTED THIS ASSUMPTION BY INVESTIGATING CARDIAC VAGAL MODULATION DURING YOGA.WE EXAMINED 11 HEALTHY YOGA PRACTITIONERS (7 WOMEN AND 4 MEN, MEAN AGE: 43 +/- 11; RANGE: 26-58 YEARS). EACH INDIVIDUAL WAS SUBJECTED TO TRAINING UNITS OF 90 MIN ONCE A WEEK OVER FIVE SUCCESSIVE WEEKS. DURING TWO SESSIONS, THEY PRACTICED A YOGA PROGRAM DEVELOPED FOR CARDIAC PATIENTS BY B.K.S. IYENGAR. ON THREE SESSIONS, THEY PRACTICED A PLACEBO PROGRAM OF RELAXATION. ON EACH TRAINING DAY THEY UNDERWENT AMBULATORY 24 H HOLTER MONITORING. THE GROUP OF YOGA PRACTITIONERS WAS COMPARED TO A MATCHED GROUP OF HEALTHY INDIVIDUALS NOT PRACTICING ANY RELAXATION TECHNIQUES. PARAMETERS OF HEART RATE VARIABILITY (HRV) WERE DETERMINED HOURLY BY A BLINDED OBSERVER. MEAN RR INTERVAL (INTERVAL BETWEEN TWO R-WAVES OF THE ECG) WAS SIGNIFICANTLY HIGHER DURING THE TIME OF YOGA INTERVENTION COMPARED TO PLACEBO AND TO CONTROL (P < 0.001 FOR BOTH). THE INCREASE IN HRV PARAMETERS WAS SIGNIFICANTLY HIGHER DURING YOGA EXERCISE THAN DURING PLACEBO AND CONTROL ESPECIALLY FOR THE PARAMETERS ASSOCIATED WITH VAGAL TONE, I.E. MEAN STANDARD DEVIATION OF NN (NORMAL BEAT TO NORMAL BEAT OF THE ECG) INTERVALS FOR ALL 5-MIN INTERVALS (SDNNI, P < 0.001 FOR BOTH) AND ROOT MEAN SQUARE SUCCESSIVE DIFFERENCE (RMSSD, P < 0.01 FOR BOTH). IN CONCLUSION, RELAXATION BY YOGA TRAINING IS ASSOCIATED WITH A SIGNIFICANT INCREASE OF CARDIAC VAGAL MODULATION. SINCE THIS METHOD IS EASY TO APPLY WITH NO SIDE EFFECTS, IT COULD BE A SUITABLE INTERVENTION IN CARDIAC REHABILITATION PROGRAMS.	2007	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
17 2727  34 YOGA NIDRA RELAXATION INCREASES HEART RATE VARIABILITY AND IS UNAFFECTED BY A PRIOR BOUT OF HATHA YOGA. OBJECTIVE: THE MEASUREMENT OF HEART RATE VARIABILITY (HRV) IS OFTEN APPLIED AS AN INDEX OF AUTONOMIC NERVOUS SYSTEM (ANS) BALANCE AND, THEREFORE, MYOCARDIAL STABILITY. PREVIOUS STUDIES HAVE SUGGESTED THAT RELAXATION OR MIND-BODY EXERCISE CAN INFLUENCE ANS BALANCE POSITIVELY AS MEASURED BY HRV BUT MAY ACT VIA DIFFERENT MECHANISMS. NO STUDIES, TO THE AUTHORS' KNOWLEDGE, HAVE EXAMINED THE ACUTE RESPONSE IN HRV TO INTERVENTIONS COMBINING RELAXATION AND MIND-BODY EXERCISE. THE OBJECTIVE OF THIS STUDY WAS TO COMPARE THE ACUTE HRV RESPONSES TO YOGA NIDRA RELAXATION ALONE VERSUS YOGA NIDRA RELAXATION PRECEDED BY HATHA YOGA. DESIGN: THIS WAS A RANDOMIZED COUNTER-BALANCED TRIAL. SETTING: THE TRIAL WAS CONDUCTED IN A UNIVERSITY EXERCISE PHYSIOLOGY LABORATORY. SUBJECTS: SUBJECTS INCLUDED 20 WOMEN AND MEN (29.15+/-6.98 YEARS OF AGE, WITH A RANGE OF 18-47 YEARS). INTERVENTIONS: PARTICIPANTS COMPLETED A YOGA PLUS RELAXATION (YR) SESSION AND A RELAXATION ONLY (R) SESSION. RESULTS: THE YR CONDITION PRODUCED SIGNIFICANT CHANGES FROM BASELINE IN HEART RATE (HR; BEATS PER MINUTE [BPM], P<0.001) AND INDICES OF HRV: R-R (MS, P<0.001), PNN50 (%, P=0.009), LOW FREQUENCY (LF; %, P=0.008) AND HIGH FREQUENCY (HF; %, P=0.035). THE R CONDITION PRODUCED SIGNIFICANT CHANGES FROM BASELINE IN HEART RATE (BPM, P<0.001) AS WELL AS INDICES OF HRV: R-R (MS, P<0.001), HF (MS(2), P=0.004), LF (%, P=0.005), HF (%, P=0.008) AND LF:HF RATIO (%, P=0.008). THERE WERE NO SIGNIFICANT DIFFERENCES BETWEEN CONDITIONS AT BASELINE NOR FOR THE CHANGES FROM BASELINE FOR ANY OF THE VARIABLES. CONCLUSIONS: THESE CHANGES DEMONSTRATE A FAVORABLE SHIFT IN AUTONOMIC BALANCE TO THE PARASYMPATHETIC BRANCH OF THE ANS FOR BOTH CONDITIONS, AND THAT YOGA NIDRA RELAXATION PRODUCES FAVORABLE CHANGES IN MEASURES OF HRV WHETHER ALONE OR PRECEDED BY A BOUT OF HATHA YOGA.	2012	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
18  716  39 EFFECT OF INTEGRATED YOGA PRACTICES ON IMMUNE RESPONSES IN EXAMINATION STRESS - A PRELIMINARY STUDY. BACKGROUND: STRESS IS OFTEN ASSOCIATED WITH AN INCREASED OCCURRENCE OF AUTONOMIC, CARDIOVASCULAR, AND IMMUNE SYSTEM PATHOLOGY. THIS STUDY WAS DONE TO EVALUATE THE IMPACT OF STRESS ON PSYCHOLOGICAL, PHYSIOLOGICAL PARAMETERS, AND IMMUNE SYSTEM DURING MEDICAL TERM -ACADEMIC EXAMINATION AND THE EFFECT OF YOGA PRACTICES ON THE SAME. MATERIALS AND METHODS: THE STUDY WAS CARRIED OUT ON SIXTY FIRST-YEAR MBBS STUDENTS RANDOMLY ASSIGNED TO YOGA GROUP AND CONTROL GROUP (30 EACH). THE YOGA GROUP UNDERWENT INTEGRATED YOGA PRACTICES FOR 35 MINUTES DAILY IN THE PRESENCE OF TRAINED YOGA TEACHER FOR 12 WEEKS. CONTROL GROUP DID NOT UNDERGO ANY KIND OF YOGA PRACTICE OR STRESS MANAGEMENT. PHYSIOLOGICAL PARAMETERS LIKE HEART RATE, RESPIRATORY RATE, AND BLOOD PRESSURE WERE MEASURED. GLOBAL ASSESSMENT OF RECENT STRESS SCALE AND SPIELBERGERS STATE ANXIETY SCORE WERE ASSESSED AT BASELINE AND DURING THE EXAMINATION. SERUM CORTISOL LEVELS, IL-4, AND IFN-GAMMA LEVELS WERE DETERMINED BY ENZYME-LINKED IMMUNOSORBENT ASSAY TECHNIQUE. RESULT: IN THE YOGA GROUP, NO SIGNIFICANT DIFFERENCE WAS OBSERVED IN PHYSIOLOGICAL PARAMETERS DURING THE EXAMINATION STRESS, WHEREAS IN THE CONTROL GROUP, A SIGNIFICANT INCREASE WAS OBSERVED. LIKEWISE, THE INDICATORS OF PSYCHOLOGICAL STRESS SHOWED HIGHLY SIGNIFICANT DIFFERENCE IN CONTROL GROUP COMPARED WITH SIGNIFICANT DIFFERENCE IN YOGA GROUP. DURING THE EXAMINATION, THE INCREASE IN SERUM CORTICAL AND DECREASE IN SERUM IFN-GAMMA IN YOGA GROUP WAS LESS SIGNIFICANT (P<0.01) THAN IN THE CONTROL GROUP (P<0.001). BOTH THE GROUPS DEMONSTRATED AN INCREASE IN SERUM IL-4 LEVELS, THE CHANGES BEING INSIGNIFICANT FOR THE DURATION OF THE STUDY. CONCLUSION: YOGA RESISTS THE AUTONOMIC CHANGES AND IMPAIRMENT OF CELLULAR IMMUNITY SEEN IN EXAMINATION STRESS.	2011	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
19 2072  40 THE EFFECT OF A SIX-WEEK PROGRAM OF YOGA AND MEDITATION ON BRACHIAL ARTERY REACTIVITY: DO PSYCHOSOCIAL INTERVENTIONS AFFECT VASCULAR TONE? BACKGROUND: CHRONIC STRESS IS ESTIMATED TO INCREASE THE RISK OF CARDIOVASCULAR (CV) EVENTS TWO-FOLD. ALTHOUGH STRESS REDUCTION HAS BEEN LINKED TO A REDUCTION IN CV EVENTS, LITTLE IS KNOWN REGARDING ITS EXACT MECHANISM OF BENEFIT. HYPOTHESIS: YOGA AND MEDITATION WILL IMPROVE PARAMETERS OF ENDOTHELIAL FUNCTION. METHODS: WE EXAMINED THE EFFECTS OF YOGA AND MEDITATION ON HEMODYNAMIC AND LABORATORY PARAMETERS AS WELL AS ON ENDOTHELIAL FUNCTION IN A 6-WEEK PILOT STUDY. SYSTOLIC AND DIASTOLIC BLOOD PRESSURES, HEART RATE, BODY MASS INDEX (BMI), FASTING GLUCOSE, LIPIDS, HS C-REACTIVE PROTEIN (CRP), AND ENDOTHELIAL FUNCTION (AS ASSESSED BY BRACHIAL ARTERY REACTIVITY) WERE ALL STUDIED AT BASELINE AND AFTER 6 WEEKS OF YOGA PRACTICE. RESULTS: A COURSE IN YOGA AND MEDITATION WAS GIVEN TO THE SUBJECTS FOR 1.5 H THREE TIMES WEEKLY FOR 6 WEEKS AND SUBJECTS WERE INSTRUCTED TO CONTINUE THEIR EFFORTS AT HOME. THIS PROSPECTIVE COHORT STUDY INCLUDED 33 SUBJECTS (MEAN AGE 55 +/- 11 YEARS) BOTH WITH (30%) AND WITHOUT (70%) ESTABLISHED CORONARY ARTERY DISEASE (CAD). THERE WERE SIGNIFICANT REDUCTIONS IN BLOOD PRESSURE, HEART RATE, AND BMI IN THE TOTAL COHORT WITH YOGA. NONE OF THE LABORATORY PARAMETERS CHANGED SIGNIFICANTLY WITH YOGA. FOR THE TOTAL COHORT THERE WAS NO SIGNIFICANT IMPROVEMENT IN ENDOTHELIAL-DEPENDENT VASODILATATION WITH YOGA TRAINING AND MEDITATION COMPARED WITH BASELINE (16.7% RELATIVE IMPROVEMENT FROM 7.2-8.4%; P = 0.3). IN THE GROUP WITH CAD, ENDOTHELIAL-DEPENDENT VASODILATATION IMPROVED 69% WITH YOGA TRAINING (6.38-10.78%; P = 0.09). CONCLUSION: YOGA AND MEDITATION APPEAR TO IMPROVE ENDOTHELIAL FUNCTION IN SUBJECTS WITH CAD.	2006	
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
20 1835  27 PSYCHOPHYSIOLOGICAL CHANGES AT THE TIME OF EXAMINATION IN MEDICAL STUDENTS BEFORE AND AFTER THE PRACTICE OF YOGA AND RELAXATION. THE EFFECT OF YOGA AND RELAXATION CHANGES IN PSYCHOPHYSIOLOGICAL PARAMETERS IN RESPONSE TO THE STRESS OF EXAMINATION IN 75 MEDICAL STUDENTS WAS STUDIED. INITIALLY FIVE PARAMETERS (ANXIETY LEVEL, HEART RATE, BLOOD PRESSURE, GALVANIC SKIN RESISTANCE AND CHOICE REACTION TIME) WERE RECORDED, A MONTH BEFORE THE EXAMINATION AND ON THE DAY OF EXAMINATION. STUDENTS WERE THEN RANDOMLY DIVIDED INTO 3 GROUP OF 25 EACH. ONE GROUP PRACTICED YOGA (GROUP- Y), AND ANOTHER GROUP PRACTICED RELAXATION (GROUP-R) REGULARLY FOR THREE MONTHS. THE THIRD GROUP WAS CONTROL GROUP (GROUP-C). ALL THE PARAMETERS WERE RECORDED AFTER THE CHANGES IN ANXIETY LEVEL, HEART RATE, BLOOD PRESSURE, AND GALVANIC SKIN RESISTANCE IN RESPONSE TO STRESS OF EXAMINATION WERE SIGNIFICANTLY ATTENUATED AND THERE WAS SIGNIFICANT IMPROVEMENT IN CHOICE REACTION TIME IN GROUP-Y AND GROUP-R AS COMPARED TO GROUP-C AFTER YOGA AND RELAXATION.	1998