1 46 264 A CLINICO-ANALYTICAL STUDY ON SEED OF WRIGHTIA ANTIDYSENTERICA LINN. AS A THERAPEUTIC EMETIC AGENT (VAMAKA YOGA) IN THE MANAGEMENT OF PSORIASIS. OBJECTIVES: WRIGHTIA ANTIDYSENTERICA LINN. (WA) IS MALE VARIETY KUTAJA STATED TO BE POTENT THERAPEUTIC EMETIC AGENT IN SKIN DISORDERS. EXPULSION OF DOSHAS THROUGH ORAL ROUTE IS TERMED AS VAMANA KARMA (VK) (THERAPEUTIC EMESIS). HOWEVER, SO FAR, ITS UTILITY FOR VAMANA IS NOT EXPLORED IN DETAIL, THEREFORE THERE IS A NEED TO REVALIDATE THE UTILITY OF WA FOR VAMANA. HENCE, THE ABOVE STUDY WAS CONDUCTED TO ASCERTAIN THE EFFICACY AS A THERAPEUTIC EMETIC AGENT (VAMAKA YOGA) IN THE MANAGEMENT OF PSORIASIS ALONG WITH QUALITY CONTROL AND STANDARDIZATION OF THIS HERB. MATERIALS AND METHODS: THE DRUG WAS STANDARDIZED AS PER ANALYTICAL PROCEDURES IN PHARMACOPEIAS. THIRTY PATIENTS OF PSORIASIS FULFILLING INCLUSION CRITERIA WERE TAKEN FOR THE STUDY AND VAMANA WITH WA WAS CONDUCTED. CRITERIA WERE PREPARED TO ASSESS THE SIGNS AND SYMPTOMS OF PSORIASIS. VK WAS ASSESSED USING THE CLASSICAL LAKSHANAS (FEATURES) SUCH AS ANTHIKI SHUDHI (ENDING SYMPTOMS OF EMESIS), VAIGIKI SHUDHI (FEATURES OF VOMITING BOUTS), MANIKI SHUDHI (QUANTITATIVE AND QUALITATIVE PURIFICATION), COMPLICATIONS. RESULT: VK WITH WA SHOWED SIGNIFICANT RELIEF IN PARAMETERS OF PSORIASIS SUCH AS SCALING, ITCHING, CANDLE GREASE SIGN (P < 0.001), AND PSORIASIS AREA AND SEVERITY INDEX SCORE (P = 0.001). IN VK WITH WA, MEAN NUMBER OF VEGAS (VOMITING BOUTS) WAS 6.91. 66% PATIENTS SHOWING QUANTITATIVE PURIFICATION BETWEEN 301 AND 600 ML. 73.33% SHOWED ALL SYMPTOMS OF PURIFICATION. 73.33% PATIENTS SHOWED KAPHANTA VAMANA (MODERATE EXPULSION OF DESIRE HUMOR). IN THE LEVEL OF BIOPURIFICATION, 66.66% PATIENTS SHOWED MODERATED PURIFICATION. NO COMPLICATION WAS NOTED WITH MODERATE DRUG PALATABILITY. CONCLUSION: PHARMACOPEIAL ANALYTICAL STUDY SHOWED ITS STANDARDIZED VALUES FOR TESTING THE DRUG USED FOR THE STUDY. IT IS PROVED AS POTENT THERAPEUTIC EMETIC AGENT WITH NO COMPLICATION SHOWED ITS CLINICAL BENEFITS OVER SKIN DISORDER LIKE PSORIASIS. SUMMARY: SEEDS OF WRIGHTIA ANTIDYSENTERICA (WA) LINN. FREE FROM ANY FOREIGN MATTER WERE SELECTED FOR THE STUDY. LOSS ON DRYING REVEALED 6.535% MOISTURE CONTENT; TOTAL ASH INDICATING OF TOTAL INORGANIC CONTENT WAS FOUND TO BE 5.12%; ACID INSOLUBLE ASH IS THE ACID INSOLUBLE PART OF TOTAL ASH, MAINLY SILICA, WA SHOWED 0.393% ACID INSOLUBLE ASH; ETHANOL AND WATER SOLUBLE EXTRACTIVE IS INDICATIVE OF PERCENTAGE ACTIVE CONSTITUENTS WERE FOUND TO BE 25.66 AND 20.854%, RESPECTIVELY. HIGH-PERFORMANCE THIN LAYER CHROMATOGRAPHY FINGERPRINTING PROFILES OF WA UNDER 254 NM SHOWED THE PRESENCE OF 7 SPOTS (ALL IN GREEN) AT RF VALUES RANGING FROM 0.21 TO 0.88. UNDER 366 NM THERE WERE 4 PROMINENT SPOTS (ALL IN FLUORESCENT) AT RF 0.49 TO 0.82 AND, WHEN SCANNED UNDER WHITE LIGHT 620 NM FOLLOWING DERIVATIZATION WITH VANILLIN SULFURIC ACID 6 SPOTS (IN DIFFERENT COLORS) WERE EVIDENT AT RF 0.28 TO 0.58. AMONG THESE SPOT WITH RF OF 0.58 WAS COMMON WHEN VISUALIZED UNDER ALL THE THREE METHODS. RF VALUES BY DENSITOMETRIC SCAN OF WA SHOWED 12 PEAKS AT 254 NM AND 5 PEAKS AT 366 NM. HOWEVER, IN CLINICAL TRIAL, IT WAS FOUND TO BE A POTENT EMETIC AGENT WITHOUT ANY COMPLICATION. ABBREVIATIONS USED: WA: WRIGHTIA ANTIDYSENTERICA; LINN.; VK: VAMANA KARMA; BT: BEFORE TREATMENT; FP: FREIDMAN'S P VALUE; CHS: CHI-SQUARE VALUE; NR: NEGATIVE RANKS; PR: POSITIVE RANKS; N: SAMPLE NUMBER, AS: AUSTIPZ SIGN; CG: CANDLE GREASE TEST; SSL: SAMYAK SNIGDHA LAKSHANA. 2016 2 1993 25 STANDARDISATION OF KUTAJADI VISHESH YOGA. AMOEBIASIS IS A PROBLEM IN NORTHERN INDIA. IN AYURVEDA SEVERAL HERBAL DRUGS ARE MENTIONED, TO BE USED FOR CONTROLLING THE AMATISARA (AMOEBIASIS) BUT NONE OF THE DRUG ARE FOUND HAVING POTENT EFFECT TO IRADICATE THE DISEASE. IN ANCIENT LITERATURE KUTAJ (HOLARRHENA ANTIDYSENTRICA) IS MENTIONED IN COMMONEST WAS FOR CONTROLLING THE DISEASE THIS PLANT IS PREVALENTLY FOUND IN HIMALAYAN AND VINDHAYA AREA. IT IS VERY EFFECTIVE FOR RELIEVING AMOEBIASIS. BY SEEING ITS THEURAPTIC IMPORTANCE WE HAVE TRIED TO STANDARDIZE THE COMPOUND IN WHOLE WITH SPECIAL REFERENCE TO KUTAJ. THE DETAIL COMPOSITION AND METHOD OF PREPARATION OF DRUG WITH ITS THERAPEUTIC EFFECT WILL BE NARRATED DURING THE TIME OF WORKSHOP. 1998 3 1764 25 POSTNATAL DEVELOPMENT AND REPRODUCTIVE PERFORMANCE OF F1 PROGENY EXPOSED IN UTERO TO AN AYURVEDIC CONTRACEPTIVE: PIPPALIYADI YOGA. PIPPALIYADI YOGA OR PIPPALIYADI VATI IS AN AYURVEDIC CONTRACEPTIVE USED IN INDIA SINCE ANCIENT TIMES. IT IS A COMBINATION OF POWDERED FRUIT BERRIES OF EMBELIA RIBES BURM.F. (MYRSINACEAE), PIPER LONGUM L. (PIPERACEAE) AND BORAX IN EQUAL PROPORTION. THOUGH THE CONTRACEPTIVE POTENTIAL IS KNOWN SINCE ANCIENT TIMES, NO SYSTEMATIC DEVELOPMENTAL TOXICITY STUDIES HAVE BEEN CARRIED OUT. THE PRESENT STUDY WAS CARRIED OUT TO EVALUATE THE POSTNATAL DEVELOPMENTAL TOXICITY AND THE REPRODUCTIVE PERFORMANCE OF THE PROGENY EXPOSED IN UTERO TO PIPPALIYADI. PIPPALIYADI YOGA WAS OBTAINED FROM NATIONAL INSTITUTE FOR PHARMACEUTICAL EDUCATION AND RESEARCH (NIPER), INDIA AND THE DEVELOPMENTAL TOXICITY WAS STUDIED BY ADMINISTERING THREE DOSES, VIZ. 140, 300 AND 700 MG/(KG DAY) TO GRAVID FEMALES FROM DAY 6 TO DAY 16 OF GESTATION. PIPPALIYADI DID NOT HAVE ANY ADVERSE DEVELOPMENTAL EFFECTS WITH LOW DOSES, HOWEVER, WITH THE FIVE TIMES HIGHER DOSE, A DECREASE IN BODY WEIGHT OF THE PUPS WAS OBSERVED. THE REPRODUCTIVE PERFORMANCE OF THE PROGENY BORN TO MOTHERS TREATED WITH PIPPALIYADI WAS NOT SIGNIFICANTLY AFFECTED. THE PRESENT STUDY SUGGESTS THAT IN UTERO EXPOSURE TO PIPPALIYADI DOES NOT HAVE ANY ADVERSE EFFECT ON THE POSTNATAL DEVELOPMENT AND REPRODUCTIVE PERFORMANCE OF THE F(1) PROGENY. 2007 4 481 34 CLINICAL EFFICACY OF APAMARGA KSHARA YOGA IN THE MANAGEMENT OF SHVITRA (VITILIGO). INTRODUCTION: VITILIGO IS A PROGRESSIVE, IDIOPATHIC, PIGMENTATION DISORDER OF THE SKIN, CHARACTERIZED BY HYPOPIGMENTED PATCHES. THIS CONDITION IS COMPARED WITH SHVITRA IN AYURVEDA. MANY AYURVEDIC DRUGS ARE BENEFICIAL IN SUCH CASES AND APAMARGA KSHARA YOGA IS ONE AMONG THEM. AIM: TO EVALUATE THE EFFICACY OF APAMARGA KSHARA YOGA IN LEPA AND OINTMENT FORMS IN THE MANAGEMENT OF SHVITRA. MATERIALS AND METHODS: TOTAL 50 PATIENTS OF SHVITRA WERE RANDOMLY GROUPED INTO TWO. PATIENTS REGISTERED IN GROUP A (N = 25) WERE TREATED WITH APAMARGA KSHARA YOGA LEPA AND GROUP B (N = 25) WITH APAMARGA KSHARA YOGA OINTMENT FOR 2 MONTHS. RASAYANA CHURNA (3G) ALONG WITH HONEY AND GHEE WAS GIVEN TWICE DAILY INTERNALLY IN THE BOTH GROUPS. RESULTS: SIGNIFICANT IMPROVEMENT WAS FOUND IN THE SYMPTOMS OF SHVITRA WITH TREATMENT IN BOTH THE GROUPS. THE DIFFERENCE IN BETWEEN THE GROUPS WAS STATISTICALLY INSIGNIFICANT. CONCLUSION: BOTH FORMS OF APAMRAGA KSHARA YOGA ARE EFFECTIVE IN CASES OF SHVITRA AND CAN BE GOOD ALTERNATIVES FOR CONTEMPORARY MEDICINES. 2015 5 1433 22 IMPROVING THE DEGREE OF PUBIC ARCH POST-YOGA EXERCISE DURING PREGNANCY. YOGA EXERCISES UNDERTAKEN DURING THE MATERNITY PERIOD MAY REDUCE UNPLEASANT SYMPTOMS DURING PREGNANCY AND REDUCE DELIVERY PAIN. FLEXIBILITY OF THE HIP JOINT IMPROVES THE DEGREE OF PUBIC ARCH CREATED IN AN OPEN-LEG POSTURE AND WIDENS THE PELVIC OUTLET REGION, SHORTENING THE TIME REQUIRED FOR DELIVERY AND FACILITATING EASY DELIVERY. THE DEGREE OF PUBIC ARCH IS RELATED TO THE FLEXIBILITY OF THE HIP JOINT. ALTHOUGH MANY STUDIES HAVE SHOWN THE EFFECT OF YOGA EXERCISE DURING PREGNANCY, THE EFFECT ON THE DEGREE OF THE PUBIC ARCH HAS NOT BEEN ELUCIDATED. TO ELUCIDATE WHETHER THE DEGREE OF THE PUBIC ARCH IS IMPROVED BY YOGA EXERCISE DURING PREGNANCY, THIS STUDY ENROLLED 177 PREGNANT SUBJECTS. THE DEGREE OF PUBIC ARCH PRE- AND POST-YOGA EXERCISE WAS MEASURED USING INSTRUMENTS IN AN OPEN-LEG POSTURE (SEATED WITH FEMURS ABDUCTED). THE MEAN PUBIC ARCH PRE- AND POST-YOGA WAS 122.61 AND 127.93 DEGREES, RESPECTIVELY. THE DEGREE OF PUBIC ARCH POST-YOGA SESSIONS WAS SIGNIFICANTLY INCREASED COMPARED WITH PRE-YOGA SESSIONS (P < 0.01). THIS STUDY SHOWED THAT YOGA EXERCISES DURING THE PREGNANCY PERIOD APPEAR TO IMPROVE THE DEGREE OF PUBIC ARCH. 2021 6 1128 55 EFFICACY OF VAMANA KARMA WITH IKSHVAKU KSHEERA YOGA IN THE MANAGEMENT OF TAMAKA SHVASA (BRONCHIAL ASTHMA). INTRODUCTION: BRONCHIAL ASTHMA IS A HIGHLY PREVALENT DISEASE, AND IN MOST OF THE ETIOPATHOGENESIS AND SYMPTOMATOLOGY, IT CAN BE CORRELATED WITH TAMAKA SHVASA. IKSHVAKU (LAGENARIA VULGARIS [MANILA] STANDLEY.) IS AN ANNUAL HERBACEOUS CLIMBING PLANT WITH A LONG HISTORY OF MEDICINAL USES FOR THE TREATMENT OF VARIOUS AILMENTS INCLUDING JAUNDICE, DIABETES, ULCER, PILES, COLITIS, ASTHMA, INSANITY, HYPERTENSION, CONGESTIVE CARDIAC FAILURE AND SKIN DISORDERS. ITS FRUIT PULP IS USED BOTH AS AN EMETIC AND AS A PURGATIVE. AIMS: TO STUDY THE EFFICACY OF VAMANA KARMA WITH IKSHVAKU (LAGENARIA VULGARIS [MANILA] STANDLEY) KSHEERA YOGA. MATERIALS AND METHODS: A TOTAL OF 15 PATIENTS FULFILLING THE DIAGNOSTIC CRITERIA FOR BRONCHIAL ASTHMA WERE SELECTED FROM OUTPATIENT AND INPATIENT DEPARTMENT OF PANCHAKARMA DEPARTMENT. THE SIGN AND SYMPTOMS, MAINLY BREATHLESSNESS, COUGH AND RHONCHI WERE GIVEN SCORES DEPENDING ON THEIR SEVERITY. THE PATIENTS WERE ALSO ASSESSED FOR LUNG FUNCTION TEST TO DETERMINE PULMONARY IMPAIRMENT. FOR VAMANA, THEY WERE GIVEN DEEPANA AND PACHANA WITH TRIKATU CHURNA FOR 3 DAYS AND THEN THEY WERE SUBJECTED TO SNEHAPANA WITH LUKEWARM COW'S GHEE. AFTER THE COMPLETION OF SNEHAPANA, THE PATIENT WERE GIVEN ABHYANGA, VASHPA SWEDANA AND DIET WITH PREDOMINANCE OF KAPHA (KAPHA BAHULA AHARA- DIET MIXED WITH MILK OR CURD), WHICH WAS THEN FOLLOWED BY VAMANA WITH IKSHVAKU KSHEERA YOGA AND SAMSARJANA KRAMA. FOLLOW-UP WAS DONE AT AN INTERVAL OF 15 DAYS FOR THREE TIMES AND T SCORES WERE NOTED BEFORE AND AFTER THE TREATMENT. THE SCORES WERE ANALYZED USING WILCOXON SIGNED-RANK TEST FOR SUBJECTIVE PARAMETERS AND STUDENT'S PAIRED T-TEST FOR OBJECTIVE PARAMETERS. RESULTS: THE TRIAL DRUG HAS SHOWN STATISTICALLY HIGHLY SIGNIFICANT REDUCTION IN BREATHLESSNESS, COUGH, RHONCHI, AND SIGNIFICANT CHANGES IN LUNG FUNCTION TESTS. CONCLUSION: THE TEST DRUG PROVED ITS EMETIC EFFECT ON THE PATIENTS OF BRONCHIAL ASTHMA AND THUS RELIEVED THE SYMPTOMS OF THE DISEASE IMMEDIATELY. IT HAS REDUCED FREQUENCY OF EPISODES OF BREATHLESSNESS AND SEVERITY OF SYMPTOMS. 2017 7 1360 33 IMMEDIATE EFFECTS OF YOGA BREATHING WITH INTERMITTENT BREATH HOLDING ON RESPONSE INHIBITION AMONG HEALTHY VOLUNTEERS. BACKGROUND: THERE IS VERY LITTLE EVIDENCE AVAILABLE ON THE EFFECTS OF YOGA-BASED BREATHING PRACTICES ON RESPONSE INHIBITION. THE CURRENT STUDY USED STOP-SIGNAL PARADIGM TO ASSESS THE EFFECTS OF YOGA BREATHING WITH INTERMITTENT BREATH HOLDING (YBH) ON RESPONSE INHIBITION AMONG HEALTHY VOLUNTEERS. MATERIALS AND METHODS: THIRTY-SIX HEALTHY VOLUNTEERS (17 MALES + 19 FEMALES), WITH MEAN AGE OF 20.31 +/- 3.48 YEARS FROM A UNIVERSITY, WERE RECRUITED IN A WITHIN-SUBJECT REPEATED MEASURES (RM) DESIGN. THE RECORDINGS FOR STOP SIGNAL TASK WERE PERFORMED ON THREE DIFFERENT DAYS FOR BASELINE, POST-YBH, AND POST YOGIC BREATH AWARENESS (YBA) SESSIONS. STOP-SIGNAL REACTION TIME (SSRT), MEAN REACTION TIME TO GO STIMULI (GO RT), AND THE PROBABILITY OF RESPONDING ON-STOP SIGNAL TRIALS (P [R/S]) WERE ANALYZED FOR 36 VOLUNTEERS USING RM ANALYSIS OF VARIANCE. RESULTS: SSRT REDUCED SIGNIFICANTLY IN BOTH YBH (218.33 +/- 38.38) AND YBA (213.15 +/- 37.29) GROUPS WHEN COMPARED TO BASELINE (231.98 +/- 29.54). NO SIGNIFICANT CHANGES WERE OBSERVED IN GO RT AND P (R/S). FURTHER, THE CHANGES IN SSRT WERE NOT SIGNIFICANTLY DIFFERENT AMONG YBH AND YBA GROUPS. CONCLUSION: BOTH YBH AND YBA GROUPS WERE FOUND TO ENHANCE RESPONSE INHIBITION IN THE STOP-SIGNAL PARADIGM. YBH COULD BE FURTHER EVALUATED IN CLINICAL SETTINGS FOR CONDITIONS WHERE RESPONSE INHIBITION IS ALTERED. 2018 8 533 22 COMPARISON OF TWO TAGTEACH ERROR-CORRECTION PROCEDURES TO TEACH BEGINNER YOGA POSES TO ADULTS. TEACHING WITH ACOUSTICAL GUIDANCE INVOLVES AUDITORY FEEDBACK (E.G., A CLICK SOUND WHEN A DESIRED BEHAVIOR OCCURS) AS PART OF A MULTICOMPONENT INTERVENTION KNOWN AS TAGTEACH. TAGTEACH HAS BEEN FOUND TO IMPROVE PERFORMANCE IN SPORT, DANCE, SURGICAL TECHNIQUE, AND WALKING. WE COMPARED THE EFFICACY AND EFFICIENCY OF THE STANDARD TAGTEACH ERROR-CORRECTION PROCEDURE AND A MODIFIED TAGTEACH ERROR-CORRECTION PROCEDURE TO TEACH 4 NOVICE ADULT YOGA PRACTITIONERS BEGINNER YOGA POSES. BOTH ERROR-CORRECTION PROCEDURES WERE EFFECTIVE FOR ALL PARTICIPANTS; HOWEVER, THE RELATIVE EFFICIENCY OF THESE ERROR-CORRECTION PROCEDURES WAS UNCLEAR. RESULTS ARE DISCUSSED IN TERMS OF LIMITATIONS AND CONSIDERATIONS FOR FUTURE RESEARCH. 2020 9 483 53 CLINICAL EFFICACY OF VAMANA KARMA WITH IKSHWAAKU BEEJA YOGA FOLLOWED BY SHATAPUSHPADI GHANAVATI IN THE MANAGEMENT OF ARTAVA KSHAYA W. S. R TO POLYCYSTIC OVARIAN SYNDROME. BACKGROUND: DUE TO SEDENTARY LIFESTYLE AND STRESS, THE INCIDENCE OF METABOLIC DISORDERS ARE INCREASING DAY BY DAY. AMONG THESE POLYCYSTIC OVARIAN SYNDROME (PCOS) IS AN INTRICATE DISORDER AFFECTING 4%-8% WOMEN IN THEIR REPRODUCTIVE AGE AND RELATED TO OVARIAN DYSFUNCTION CHARACTERIZED BY OBESITY, OLIGOMENORRHEA, ANOVULATION AND HYPERANDROGENISM. IN MODERN SYSTEM OF MEDICINE, THE AVAILABLE ALLOPATHIC REGIMEN HAS ITS OWN LIMITATIONS, SO IT IS NEED OF TIME TO FIND A SAFE AND EFFECTIVE ALTERNATIVE THERAPY FOR SUCH TYPE OF CONDITION. THE MOST COMMON SYMPTOM IN 85%-90% OF PCOS PATIENTS IS OLIGOMENORRHEA WHICH CAN BE CORRELATED TO ARTAVA KSHAYA (LOSS OF MENSTRUAL FLUID) IN AYURVEDA. HENCE, IN THE PRESENT CLINICAL STUDY, VAMANA KARMA (THERAPEUTIC VOMITING) WITH IKSHWAAKU SEED FORMULATION FOLLOWED BY SHATAPUSHPADI GHANAVATI WAS PLANNED. AIMS: TO EVALUATE THE EFFICACY OF VAMANA KARMA (THERAPEUTIC VOMITING) FOLLOWED BY SHATAPUSHPADI GHANAVATI IN THE MANAGEMENT OF AARTAVA KSHAYA (LOSS OF MENSTRUAL FLUID) W. S. R TO PCOS. MATERIALS AND METHODS: A TOTAL OF 15 PATIENTS OF PCOS WERE CLINICALLY DIAGNOSED AND TREATED BY VAMANA KARMA (THERAPEUTIC VOMITING) PROCEDURE WITH IKSHWAAKU SEED FORMULATION. AFTER COMPLETION OF VAMANA KARMA (THERAPEUTIC VOMITING) AND SAMSARJANA KRAMA, (POST THERAPY DIETARY REGIMEN FOR REVIVAL) SHATAPUSHPADI GHANAVATI 2 VATI (EACH 500 MG) TWICE IN A DAY WITH LUKEWARM WATER WAS GIVEN FOR 45 DAYS. AFTER COMPLETION OF 2-MONTH TRIAL, ASSESSMENT OF THERAPY WAS ESTIMATED BY SUBJECTIVE AND OBJECTIVE PARAMETERS. RESULTS: STATISTICALLY EXTREMELY SIGNIFICANT (P < 0.0001) RESULTS WERE FOUND IN MENSTRUAL IRREGULARITIES, OBESITY, AND BODY MASS INDEX. THE SIGNIFICANT RESULT IN REDUCTION OF NONDOMINANT FOLLICLES (P = 0.01 AND 0.03 FOR RIGHT AND LEFT OVARY, RESPECTIVELY), LOWERING THE FASTING BLOOD SUGAR LEVEL (P = 0.02) AND HIRSUTISM (P = 0.03) WAS FOUND. CONCLUSION: VAMANA KARMA (THERAPEUTIC VOMITING) FOLLOWED BY SHATAPUSHPADI GHANAVATI IS VERY EFFECTIVE IN THE MANAGEMENT OF OBESE PCOS PATIENTS AND INCREASING CHANCES OF CONCEPTION. 2017 10 607 45 DEVELOPMENT OF A CHEWABLE TABLET FROM DUGDHAMALAKYADI YOGA: AN AYURVEDIC PREPARATION. BACKGROUND: AMALAKI (EMBELICA OFFICINALIS GAERTN.) IS ONE OF THE MOST CELEBRATED HERBS IN THE INDIAN SYSTEM OF TRADITIONAL MEDICINE. IT IS ONE OF THE BEST RASAYANA-S (HEALTH PROMOTING) DRUG. IN DUGDHAMALAKYADI YOGA, AMALAKI (EMBELICA OFFICINALIS GAERTN.) POWDER IS ADMINISTERED ALONG WITH MILK IN CASE OF SVARABHANGA (HOARSENESS OF VOICE). HERE AN ATTEMPT IS MADE TO CONVERT THIS FORMULATION INTO CHEWABLE TABLET WITHOUT ALTERING ITS PROPERTY TO IMPROVE ITS PALATABILITY, SHELF LIFE AND FIXATION OF PROPER THERAPEUTIC DOSE. METHODOLOGY: CHEWABLE TABLETS WERE PREPARED BY WET GRANULATION METHOD. HERE, AMALAKI POWDER WAS PREPARED INITIALLY AND IT WAS MIXED WITH ADDITIVES AND PRESERVATIVES. GRANULES WERE PREPARED FROM THIS MIXTURE BY ADDING BINDING AGENT, FINALLY COMPRESSED IN TO TABLETS. RESULTS AND CONCLUSION: THE PHYSICO-CHEMICAL ANALYSIS OF AMALAKI STANDARD ARE: FOREIGN MATTER-NIL, ACID INSOLUBLE ASH-0.51%W/W, WATER SOLUBLE ASH-2.01% W/W, ALCOHOLIC EXTRACTIVES-44.48%, AQUEOUS EXTRACTIVES 67.52%, PH-3.1, MOISTURE CONTENT-8.19%. QUALITY CONTROL TEST FOR CHEWABLE TABLET WAS CARRIED OUT AND FOUND SATISFACTORY WITH GENERAL CHARACTERISTICS OF TABLET VIZ. HARDNESS 1.8, DISINTEGRATION TIME 15-20 MIN, FRIABILITY 0.5%, WEIGHT VARIATION +/- 3%. THE TLC OF AMALAKI POWDER SHOWED 3 SPOTS WITH RF VALUE 0.14, 0.4, AND 0.73 AND THE CHEWABLE TABLETS SHOWED 2 SPOTS WITH RF VALUE 0.31 AND 0.89 UNDER 254 NM. THE ADAPTATION OF MODERN TECHNIQUES OR METHODS TO CONVERT THE AYURVEDIC FORMULATIONS WITHOUT ALTERING ITS THERAPEUTIC PROPERTY IS NECESSARY TO MADE THEM SUITABLE FOR THE PRESENT TRENDS OF NEWER DRUG DELIVERY DOSAGE FORMS. 2012 11 32 40 5-HTTLPR AND MTHFR 677C>T POLYMORPHISMS AND RESPONSE TO YOGA-BASED LIFESTYLE INTERVENTION IN MAJOR DEPRESSIVE DISORDER: A RANDOMIZED ACTIVE-CONTROLLED TRIAL. BACKGROUND: THERE IS GROWING EVIDENCE SUGGESTING THAT BOTH GENETIC AND ENVIRONMENTAL FACTORS MODULATE TREATMENT OUTCOME IN, A HIGHLY HETEROGENEOUS, MAJOR DEPRESSIVE DISORDER (MDD). 5-HTTLPR VARIANT OF THE SEROTONIN TRANSPORTER GENE (SLC6A4) AND MTHFR 677C>T POLYMORPHISMS HAVE BEEN LINKED TO THE PATHOGENESIS OF MDD, AND ANTIDEPRESSANT TREATMENT RESPONSE. THE EVIDENCE IS LACKING ON THE CLINICAL UTILITY OF YOGA IN PATIENTS WITH MDD WHO HAVE 5-HTTLPR AND MTHFR 677C>T POLYMORPHISMS AND LESS LIKELY TO RESPOND TO MEDICATIONS (SSRIS). AIMS: WE AIMED TO EXAMINE THE IMPACT OF YBLI IN THOSE WHO HAVE SUSCEPTIBLE 5-HTTLPR AND MTHFR 677C>T POLYMORPHISMS AND ARE LESS LIKELY TO DRUG THERAPY WITH SSRIS. SETTINGS AND DESIGN: IN A 12 WEEK RANDOMIZED ACTIVE-CONTROLLED TRIAL, MDD PATIENTS (N = 178) WERE RANDOMIZED TO RECEIVE YBLI OR DRUG THERAPY. METHODS: GENOTYPING WAS CONDUCTED USING PCR-BASED METHODS. THE CLINICAL REMISSION WAS DEFINED AS BDI-II SCORE T GENOTYPES SHOWED STATISTICALLY SIGNIFICANT ODDS OF REMISSION IN YOGA ARM VS. DRUG ARM. NEITHER 5-HTTLPR NOR MTHFR 677C>T GENOTYPE SHOWED ANY INFLUENCE ON REMISSION TO YBLI (P = 0.73 AND P = 0.64, RESPECTIVELY). FURTHER ANALYSIS SHOWED CHILDHOOD ADVERSITY INTERACT WITH 5-HTTLPR AND MTHFR 677C>T POLYMORPHISMS TO DECREASE TREATMENT RESPONSE IN DRUG TREATMENT ARM, BUT NOT IN YOGA ARM. CONCLUSIONS: YBLI PROVIDES MDD REMISSION IN THOSE WHO HAVE SUSCEPTIBLE 5-HTTLPR AND MTHFR 677C>T POLYMORPHISMS AND ARE RESISTANT TO SSRIS TREATMENT. YBLI MAY BE THERAPEUTIC FOR MDD INDEPENDENT OF HETEROGENEITY IN ITS ETIOPATHOGENESIS. 2018 12 1323 32 HEMODYNAMIC OBSERVATIONS OF TUMO YOGA PRACTITIONERS IN A HIMALAYAN ENVIRONMENT. BACKGROUND: FEW ATTEMPTS HAVE BEEN MADE TO EVALUATE THE PHYSIOLOGY OF TRADITIONAL EASTERN HEALTH PRACTICES. THE GOAL OF THIS STUDY WAS TO EVALUATE THE HEMODYNAMIC EFFECTS OF THE MYSTERIOUS BUDDHIST PRACTICE OF TUMO. TUMO IS A MEDITATIVE PRACTICE THAT PRODUCES INNER HEAT THROUGH THE ALLEGED CULTIVATION OF BODY ENERGY-CHANNELS. METHODS: THIS STUDY WAS PERFORMED BY MEMBERS OF AN INTERNATIONAL EXPEDITION TO THE HIMALAYAN MOUNTAINS IN THE REPUBLIC OF INDIA. THE STUDY WAS PERFORMED IN AN UNPOPULATED OUTDOOR MOUNTAINOUS AREA AT AN ALTITUDE OF 16,400 FT WITH AMBIENT TEMPERATURES BETWEEN -10 AND -15( DEGREES )C. TWO (2) COHORTS OF SUBJECTS WERE STUDIED: HEALTHY NON-YOGI VOLUNTEERS AND TUMO PRACTITIONERS. ALL OF THE SUBJECTS WERE STRIPPED DOWN TO THEIR UNDERCLOTHES AND EXPOSED TO THE SUBZERO ATMOSPHERIC TEMPERATURES FOR 5 MINUTES. THE VOLUNTEERS WERE THEN PASSIVELY REWARMED WHILE THE TUMO PRACTITIONERS PERFORMED TUMO FOR UP TO 10 MINUTES. BLOOD PRESSURE, HEART RATE, AND STROKE VOLUME INDEX (SVI) AND CARDIAC INDEX WERE MEASURED NONINVASIVELY USING A NICOM HEMODYNAMIC MONITOR, WHILE CAROTID BLOOD FLOW AND BIVENTRICULAR PERFORMANCE WERE DETERMINED ECHOCARDIOGRAPHICALLY AT EACH STAGE OF THE EXPERIMENT. THE TOTAL PERIPHERAL RESISTANCE INDEX (TPRI), LEFT VENTRICULAR EJECTION FRACTION (LVEF), AND TRICUSPID ANNULAR PLANE SYSTOLIC EXCURSION (TAPSE) WERE DETERMINED USING STANDARD FORMULA. RESULTS: FOURTEEN (14) SUBJECTS (SIX VOLUNTEERS AND EIGHT TUMO PRACTITIONERS) COMPLETED THE STUDY. THERE WAS ONE FEMALE SUBJECT IN EACH GROUP. WITH COLD EXPOSURE, THE SVI AND CAROTID BLOOD FLOW DECREASED WHILE THE TPRI INCREASED SIGNIFICANTLY IN BOTH GROUPS. IN THE VOLUNTEER GROUP, THESE CHANGES RETUNED TO BASELINE WITH REWARMING. FOLLOWING TUMO, THE CARDIAC INDEX (4.8+/-0.6 VERSUS 4.0+/-0.5 L/M(2); P<0.01), CAROTID BLOOD FLOW (445+/-127 VERSUS 325+/-100 ML/MIN/M(2), P<0.01), LVEF (68+/-5 VERSUS 64+/-7%; P<0.05) AND TAPSE (2.9+/-0.4 VERSUS 2.4+/-0.5 CM; P<0.01) WERE SIGNIFICANTLY HIGHER WHEN COMPARED WITH BASELINE, WHILE THE TPRI WAS SIGNIFICANTLY LOWER (1786+/-189 VERSUS 2173+/-281; P<0.01). CONCLUSIONS: TUMO WAS ASSOCIATED WITH A HYPERDYNAMIC VASODILATED STATE WITH INCREASED BIVENTRICULAR PERFORMANCE. WE POSTULATE THAT TUMO RESULTS IN A MASSIVE INCREASE IN SYMPATHETIC ACTIVITY WITH ACTIVATION OF BROWN ADIPOSE TISSUE AND MARKED HEAT PRODUCTION. THE INCREASED HEAT PRODUCTION MAY EXPLAIN THE PARADOXICAL VASODILATATION IN TUMO PRACTITIONERS EXPOSED TO SUBZERO TEMPERATURES. 2014 13 479 34 CLINICAL EFFECT OF NIRGUNDI PATRA PINDA SWEDA AND ASHWAGANDHADI GUGGULU YOGA IN THE MANAGEMENT OF SANDHIGATA VATA (OSTEOARTHRITIS). SANDHIGATA VATA IS ONE AMONG THE 80 NANATMAJA VATA VYADHIES. SANDHIGATA VATA AND OSTEOARTHRITIS HAVE COMMON SYMPTOMS, AND HENCE, BOTH ARE CONSIDERED AS SIMILAR ENTITIES BY A MAJORITY OF AYURVEDIC SCHOLARS AND SAME HAS BEEN ADOPTED HERE. OSTEOARTHRITIS IS THE MOST COMMON JOINT DISEASE AMONG HUMAN BEINGS TODAY. IN THIS STUDY, A TOTAL OF 116 PATIENTS WERE REGISTERED, OUT OF THEM 101 PATIENTS HAD COMPLETED THE FULL COURSE OF TREATMENT, WHILE 15 PATIENTS LEFT AGAINST MEDICAL ADVICE. THE 101 PATIENTS OF SANDHIGATA VATA WERE TREATED IN TWO GROUPS. GROUP A: IN THIS GROUP 50 PATIENTS OF SANDHIGATA VATA WERE TREATED WITH NIRGUNDI PATRA PINDA SWEDA FOR 21 DAYS AND ASHWAGANDHADI GUGGULU YOGA3 G/DAY FOR 45 DAYS WAS GIVEN ORALLY. GROUP B: IN THIS GROUP 51 PATIENTS OF SANDHIGATA VATA WERE TREATED WITH ONLY ASHWAGANDHADI GUGGULU YOGA 3 G/DAY FOR 45 DAYS. TO ASSESS THE EFFECT OF THE THERAPY OBJECTIVELY, ALL THE SIGNS AND SYMPTOMS OF SANDHIGATA VATA WERE GIVEN A SCORE, DEPENDING UPON THEIR SEVERITY. ALSO FUNCTIONAL TESTS LIKE WALKING TIME, CLIMBING STAIRS, AND JOINT MOVEMENT, WERE MEASURED AS A CRITERIA FOR ASSESSMENT. BOTH THE GROUPS SHOWED GOOD RESULTS, BUT GROUP B SHOWED BETTER RESULTS IN COMPARISON TO GROUP A. 2011 14 487 31 CLINICAL STUDY OF AN AYURVEDIC COMPOUND (DIVYADI YOGA) IN THE MANAGEMENT OF SHAYYAMUTRATA (ENURESIS). CHILD HEALTH HAS ASSUMED GREAT SIGNIFICANCE IN ALL OVER WORLD. ITS IMPORTANCE IS BEING REALIZED MORE AND MORE BY PEDIATRICIANS AND GENERAL PUBLIC IN DEVELOPING AS WELL AS DEVELOPED COUNTRIES. ENURESIS IS DEFINED AS THE VOLUNTARY OR INVOLUNTARY REPEATED DISCHARGE OF URINE INTO CLOTHES OR BED AFTER A DEVELOPMENTAL AGE WHEN BLADDER CONTROL SHOULD BE ESTABLISHED. THE PRESENT CLINICAL STUDY WAS PLANNED TO EVALUATE THE EFFECT OF DIVYADI YOGA ALONG WITH COUNSELING IN THE MANAGEMENT OF SHAYYAMUTRA. TOTAL 40 SELECTED CASES WERE DIVIDED INTO TWO GROUPS, I.E. 20 IN EACH GROUP. ONE GROUP OF CHILDREN WERE GIVEN THE TRIAL DRUG DIVYADI YOGA (D(1)) WITH COUNSELING AND OTHER GROUP OF CHILDREN WERE GIVEN PLACEBO DIVYADI YOGA (D(2)) WITH COUNSELING. DIVYADI YOGA WAS GIVEN IN THE DOSE OF 3-6 GMS. TWICE A DAY WITH LUKE WARM WATER. THE RESULT OF THE STUDY SHOWED THAT GROUPS PROVIDED A HIGHLY SIGNIFICANT. 2010 15 1612 35 METABOLIC ENERGY CONTRIBUTIONS DURING HIGH-INTENSITY HATHA YOGA AND PHYSIOLOGICAL COMPARISONS BETWEEN ACTIVE AND PASSIVE (SAVASANA) RECOVERY. PURPOSE: THE OBJECTIVE OF THIS STUDY WAS TO INVESTIGATE METABOLIC ENERGY CONTRIBUTIONS DURING HIGH-INTENSITY HATHA YOGA (HIHY) AND TO COMPARE CHANGES IN PHYSIOLOGICAL VARIABLES BETWEEN ACTIVE AND PASSIVE RECOVERY METHODS. METHODS: THE STUDY INVOLVED 20 WOMEN YOGA INSTRUCTORS (N = 20) WHO PERFORMED 10 MIN OF HIHY (VIGOROUS SUN SALUTATION). UPON COMPLETION, THEY WERE RANDOMLY ASSIGNED TO EITHER ACTIVE (WALKING; N = 10) OR PASSIVE (SAVASANA; N = 10) RECOVERY GROUPS FOR A PERIOD OF 10 MIN. DURING HIHY, PHYSIOLOGICAL VARIABLES SUCH AS HEART RATE (HRPEAK AND HRMEAN), OXYGEN UPTAKE (VO2PEAK AND VO2MEAN), AND BLOOD LACTATE CONCENTRATIONS (PEAK LA(-)) WERE MEASURED. ENERGETIC CONTRIBUTIONS (PHOSPHAGEN; WPCR, GLYCOLYTIC; WGLY, AND OXIDATIVE; WOXI) IN KJ AND % WERE ESTIMATED USING VO2 AND LA(-) DATA. FURTHERMORE, THE METABOLIC EQUIVALENTS (METS) OF VO2PEAK AND VO2MEAN WERE CALCULATED. TO COMPARE DIFFERENT RECOVERY MODES, HRPOST, DELTAHR, VO2POST, DELTAVO2, RECOVERY LA(-), AND RECOVERY DELTALA(-) WERE ANALYZED. RESULTS: THE RESULTS REVEALED THAT HRPEAK, VO2PEAK, AND PEAK LA(-) DURING HIHY SHOWED NO DIFFERENCES BETWEEN THE TWO GROUPS (P > 0.05). VALUES OF HRPEAK, HRMEAN, METS OF VO2PEAK AND VO2MEAN, AND LA(-) DURING HIHY WERE 95.6% OF HRMAX, 88.7% OF HRMAX, 10.54 +/- 1.18, 8.67 +/-.98 METS, AND 8.31 +/- 2.18 MMOL.L(-1), RESPECTIVELY. FURTHERMORE, WOXI WAS SIGNIFICANTLY HIGHER COMPARED WITH WPCR, WGLY, AND ANAEROBIC CONTRIBUTION (WPCR + WGLY), IN KJ AND % (P < 0.0001). VO2POST AND RECOVERY DELTALA(-) WERE SIGNIFICANTLY HIGHER IN THE ACTIVE RECOVERY GROUP (P < 0.0001, P = 0.0369, RESPECTIVELY). VALUES OF DELTAVO2 AND RECOVERY LA(-) WERE SIGNIFICANTLY LOWER IN THE ACTIVE GROUP COMPARED WITH THE PASSIVE GROUP (P = 0.0115, P = 0.0291, RESPECTIVELY). CONCLUSIONS: THE STUDY CONCLUDED THAT HIGH-INTENSITY HATHA YOGA WHICH WAS PERFORMED FOR 10 MIN IS A SUITABLE OPTION FOR RELATIVELY HEALTHY PEOPLE IN THE MODERN WORKPLACE WHO MAY HAVE HATHA YOGA EXPERIENCE BUT DO NOT HAVE TIME TO PERFORM A PROLONGED EXERCISE. FOLLOWING ACTIVE RECOVERY, THEY CAN PARTICIPATE IN FURTHER HIHY SESSIONS DURING SHORT BREAKS. FURTHERMORE, A FASTER RETURN TO WORK CAN BE SUPPORTED BY PHYSIOLOGICAL RECOVERY. 2021 16 1416 17 IMPORTANCE OF MANAS TATTVA: A SEARCHLIGHT IN YOGA DARSHANA. SINCE TIME IMMEMORIAL 'MANAS' HAS BEEN THE SUBJECT OF CURIOSITY FOR SCHOLARS, SCIENTISTS AND PHILOSOPHERS. THE REASON BEHIND THIS CURIOSITY IS ITS IMPORTANCE IN THE DEVELOPMENT OF MANKIND. HUMAN BEING IS SUPERIOR TO OTHER CREATURES IN THE SERIES OF DEVELOPMENT. THIS SUPREMACY OF MAN REMAINS IN HIS QUALITY TO WORK AFTER THINKING, WHICH IS THE FUNCTION OF 'MANAS'. NO OTHER ANIMAL IS CAPABLE TO THINK LOGICALLY. THIS IS THE ONLY REASON WHICH LEADS THE MANKIND TO THE CREST OF DEVELOPMENT IN EVERY ASPECT. TO HIGHLIGHT THE CONCEPT OF MANAS IN YOGA DARSHANA, INFORMATION EXTRACTED FROM YOGA LITERATURES AND AYURVEDIC SAMHITAS. IN INDIAN CULTURE MIND HAS BEEN DESCRIBED FROM VARIOUS ANGLES. VEDIC, PHILOSOPHICAL AND AYURVEDIC LITERATURES HAVE A VAST AND EXCLUSIVE DESCRIPTION OF MANAS. PHILOSOPHERS EITHER ASTIKA OR NASTIKA HAVE DESCRIBED MANAS SIDDHANTA VIVIDLY. THOUGH MANY KINDS OF DIFFERENCE OF OPINIONS ARE THERE, YOGA DARSHANA ACCEPT THE IMPORTANCE OF MIND IN THE PROCESS OF PERCEPTION AND EVEN FOR THE BIRTH OF ANY INDIVIDUAL. 2014 17 1229 29 FEASIBILITY AND IMPACT OF AN 8-WEEK INTEGRATIVE YOGA PROGRAM IN PEOPLE WITH MODERATE MULTIPLE SCLEROSIS-RELATED DISABILITY: A PILOT STUDY. BACKGROUND: THIS PILOT STUDY DETERMINED THE FEASIBILITY OF A SPECIFICALLY DESIGNED 8-WEEK YOGA PROGRAM FOR PEOPLE WITH MODERATE MULTIPLE SCLEROSIS (MS)-RELATED DISABILITY. WE EXPLORED THE PROGRAM'S EFFECT ON QUALITY OF LIFE (QOL) AND PHYSICAL AND MENTAL PERFORMANCE. METHODS: WE USED A SINGLE-GROUP DESIGN WITH REPEATED MEASUREMENTS AT BASELINE, POSTINTERVENTION, AND 8-WEEK FOLLOW-UP. FEASIBILITY WAS EXAMINED THROUGH COST, RECRUITMENT, RETENTION, ATTENDANCE, AND SAFETY. OUTCOMES INCLUDED THE MULTIPLE SCLEROSIS QUALITY OF LIFE INVENTORY (MSQLI), 12-ITEM MULTIPLE SCLEROSIS WALKING SCALE (MSWS-12), TIMED 25-FOOT WALK TEST (T25FW), 6-MINUTE WALK TEST (6MWT), NINE-HOLE PEG TEST (NHPT), FIVE-TIMES SIT-TO-STAND TEST (FTSTS), MULTIDIRECTIONAL REACH TEST (MDRT), MAXIMUM EXPIRATORY PRESSURE, AND PACED AUDITORY SERIAL ADDITION TEST-3'' (PASAT-3''). RESULTS: FOURTEEN PARTICIPANTS COMPLETED THE STUDY. THE PROGRAM WAS FEASIBLE. THERE WERE SIGNIFICANT MAIN EFFECTS ON THE 36-ITEM SHORT FORM HEALTH STATUS SURVEY MENTAL COMPONENT SUMMARY (SF-36 MCS), MODIFIED FATIGUE IMPACT SCALE (MFIS), BLADDER CONTROL SCALE (BLCS), PERCEIVED DEFICITS QUESTIONNAIRE (PDQ), MENTAL HEALTH INVENTORY (MHI), MSWS-12, T25FW, NHPT, PASAT-3'', 6MWT, FTSTS, AND MDRT-BACK. IMPROVEMENTS WERE FOUND ON THE SF-36 MCS, MFIS, BLCS, PDQ, MHI, AND MSWS-12 BETWEEN BASELINE AND POSTINTERVENTION. THE EFFECT ON PDQ PERSISTED AT FOLLOW-UP. IMPROVEMENTS WERE FOUND ON THE T25FW, NHPT, 6MWT, FTSTS, AND MDRT-BACK BETWEEN BASELINE AND POSTINTERVENTION THAT PERSISTED AT FOLLOW-UP. THE PASAT-3'' DID NOT CHANGE BETWEEN BASELINE AND POSTINTERVENTION BUT DID BETWEEN POSTINTERVENTION AND FOLLOW-UP. CONCLUSIONS: THE YOGA PROGRAM WAS SAFE AND FEASIBLE. IMPROVEMENTS IN CERTAIN MEASURES OF QOL AND PERFORMANCE WERE SEEN AT POSTINTERVENTION AND FOLLOW-UP. 2017 18 1536 27 KETAMINE, TRANSCRANIAL MAGNETIC STIMULATION, AND DEPRESSION SPECIFIC YOGA AND MINDFULNESS BASED COGNITIVE THERAPY IN MANAGEMENT OF TREATMENT RESISTANT DEPRESSION: REVIEW AND SOME DATA ON EFFICACY. DEPRESSION AFFECTS ABOUT 121 MILLION PEOPLE WORLDWIDE AND PREVALENCE OF MAJOR DEPRESSIVE DISORDER (MDD) IN US ADULTS IS 6.4%. TREATMENT RESISTANT DEPRESSION (TRD) ACCOUNTS FOR APPROXIMATELY 12-20% OF ALL DEPRESSION PATIENTS AND COSTS $29-$48 BILLION ANNUALLY. KETAMINE AND REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (RTMS) HAVE USEFUL ROLES IN TRD, BUT THEIR UTILITY IN LONG TERM IS UNKNOWN. AS PER THE LATEST LITERATURE, THE INTERVENTIONS USING YOGA AND MEDITATION INCLUDING THE MINDFULNESS BASED COGNITIVE THERAPY (MBCT) HAVE BEEN USEFUL IN TREATMENT OF DEPRESSION AND RELAPSE PREVENTION. WE PRESENT A REVIEW OF RTMS, KETAMINE, AND MBCT AND ALSO REPORT EFFICACY OF A DEPRESSION SPECIFIC, INNOVATIVE, AND TRANSLATIONAL MODEL OF YOGA AND MINDFULNESS BASED COGNITIVE THERAPY (DEPS Y-MBCT), DEVELOPED BY THE FIRST AUTHOR. DEPS Y-MBCT AS AN ADJUNCTIVE TREATMENT SUCCESSFULLY AMELIORATED TRD SYMPTOMS IN 27/32 PATIENTS IN AN OPEN LABEL PILOT TRIAL IN TRD PATIENTS. CONSIDERING THE LIMITATIONS OF EXISTING TREATMENT OPTIONS, INCLUDING THOSE OF KETAMINE AND RTMS WHEN USED AS THE SOLE MODALITY OF TREATMENT, WE SUGGEST A "TIERED APPROACH FOR TRD" BY COMBINING KETAMINE AND RTMS (ALONE OR ALONG WITH ANTIDEPRESSANTS) FOR RAPID REMISSION OF ACUTE DEPRESSION SYMPTOMS AND TO USE DEPS Y-MBCT FOR MAINTAINING REMISSION AND PREVENTING RELAPSE. 2015 19 2108 15 THE EFFECT OF YOGA ON PUBORECTALIS PARADOX. NINE PATIENTS WITH SEVERE DEFAECATION DIFFICULTIES PRIMARILY CONSIDERED TO BE DUE TO PUBORECTALIS DYSFUNCTION (PUBORECTALIS PARADOX), VERIFIED BY ELECTROMYOGRAPHY (EMG) OF THE STRIATED ANAL SPHINCTER MUSCLES, WERE OFFERED TRAINING IN YOGIC TECHNIQUES OF RELAXATION AND MUSCLE CONTROL IN ORDER TO CHANGE THE ACTIVITY OF THE PELVIC FLOOR MUSCLES DURING ATTEMPTED DEFAECATION. FIVE PATIENTS COMPLETED THE TRAINING PROGRAM OF 20 2-HOUR SESSIONS AND WERE RE-EXAMINED CLINICALLY AND WITH EMG. ONE PATIENT REGAINED A NORMAL EMG PATTERN BUT NONE OF THE PATIENTS IMPROVED CLINICALLY. 1991 20 2164 27 THE EFFECTS OF YOGA AND SELF-ESTEEM ON MENOPAUSAL SYMPTOMS AND QUALITY OF LIFE IN BREAST CANCER SURVIVORS-A SECONDARY ANALYSIS OF A RANDOMIZED CONTROLLED TRIAL. OBJECTIVES: PREVIOUS RESEARCH HAS FOUND THAT YOGA CAN ENHANCE QUALITY OF LIFE AND EASE MENOPAUSAL SYMPTOMS OF BREAST CANCER SURVIVORS. THE STUDY EXAMINED WHETHER SELF-ESTEEM MEDIATED THE EFFECTS OF YOGA ON QUALITY OF LIFE, FATIGUE AND MENOPAUSAL SYMPTOMS, UTILIZING VALIDATED OUTCOME MEASURES. STUDY DESIGN: THIS IS A SECONDARY ANALYSIS OF A RANDOMIZED CONTROLLED TRIAL COMPARING THE EFFECTS OF YOGA WITH THOSE OF USUAL CARE IN 40 BREAST CANCER SURVIVORS WHO SUFFERED FROM MENOPAUSAL SYMPTOMS. ALL PARTICIPANTS COMPLETED ALL 3 ASSESSMENTS (WEEK 0, WEEK 12, AND WEEK 24) AND PROVIDED FULL DATA. MAIN OUTCOME MEASURES: OUTCOMES WERE MEASURED USING SELF-RATING INSTRUMENTS. MEDIATION ANALYSES WERE PERFORMED USING SPSS. RESULTS: SELF-ESTEEM MEDIATED THE EFFECT OF YOGA ON TOTAL MENOPAUSAL SYMPTOMS (B=-2.11, 95% BCI [-5.40 TO -0.37]), PSYCHOLOGICAL MENOPAUSAL SYMPTOMS (B=-0.94, 95% BCI [-2.30 TO -0.01]), AND UROGENITAL MENOPAUSAL SYMPTOMS (B=-0.66, 95% BCI [-1.65 TO -0.15]), QUALITY OF LIFE (B=8.04, 95% BCI [3.15-17.03]), SOCIAL WELL-BEING (B=1.80, 95% BCI [0.54-4.21]), EMOTIONAL WELL-BEING (B=1.62, 95% BCI [0.70-3.34]), FUNCTIONAL WELL-BEING (B=1.84, 95% BCI [0.59-4.13]), AND FATIGUE (B=4.34, 95% BCI [1.28-9.55]). SELF-ESTEEM HAD NO EFFECT ON SOMATOVEGETATIVE MENOPAUSAL SYMPTOMS (B=-0.50, 95% BCI N.S.) OR ON PHYSICAL WELL-BEING (B=0.79, 95% BCI N.S.). CONCLUSIONS: FINDINGS SUPPORT THE ASSUMPTION THAT SELF-ESTEEM PLAYS A VITAL ROLE IN THE BENEFICIAL EFFECT OF YOGA AND THAT YOGA CAN HAVE LONG-TERM BENEFITS FOR WOMEN DIAGNOSED WITH BREAST CANCER AND UNDERGOING MENOPAUSAL TRANSITION. 2017