1 3862 91 ISOPATHIC USE OF AUTO-SARCODE OF DNA AS ANTI-MIASMATIC HOMEOPATHIC MEDICINE AND MODULATOR OF GENE EXPRESSION? INTRODUCTION: IN ADDITION TO THE FOUR PILLARS OF HOMEOPATHY, VITALISM AND THE MIASMATIC THEORY ARE OFTEN USED TO EXPLAIN THE HEALTH-DISEASE PROCESS. ACCORDING TO HAHNEMANN'S CONCEPTS, HOMEOPATHIC MIASMS ARE THE MAIN OBSTACLE TO THE CURE OF CHRONIC DISEASES, WITH PSORA BEING THE FUNDAMENTAL CAUSE OF ALL FORMS OF DISEASES. ACCORDING TO MODERN GENETICS, THE DISEASE-PROMOTING EPIGENETIC ALTERATIONS ARE THE FUNDAMENTAL CAUSE OF THE MANIFESTATION OF CHRONIC DISEASES. OBJECTIVE: THIS ARTICLE DEVELOPS A PHILOSOPHICAL-SCIENTIFIC CORRELATION BETWEEN CHRONIC MIASMS AND DISEASE-PROMOTING EPIGENETIC MODIFICATIONS, AIMING TO JUSTIFY THE ISOPATHIC USE OF AUTO-SARCODE OF AN INDIVIDUAL'S DNA AS HOMEOPATHIC MEDICINE. RESULTS: BASED ON THE STUDY OF HOMEOPATHIC DOCTRINE AND EPIGENETICS, A CONCEPTUAL AND FUNCTIONAL CORRELATION IS OBSERVED BETWEEN HOMEOPATHIC CHRONIC MIASMS AND DISEASE-PROMOTING EPIGENETIC MODIFICATIONS. ADDITIONALLY, SEVERAL EXPERIMENTAL STUDIES SUGGEST THAT HOMEOPATHY'S MECHANISM OF ACTION MAY BE BY MODULATING GENE EXPRESSION. CONCLUSIONS: BY THE PHILOSOPHICAL-SCIENTIFIC CORRELATIONS DESCRIBED, IT IS INFERRED THAT DISEASE-PROMOTING EPIGENETIC ALTERATIONS ARE THE BIOLOGICAL REPRESENTATION OF THE CHRONIC MIASMS, SUGGESTING THE ISOPATHIC USE OF AUTO-SARCODE OF DNA AS HOMEOPATHIC THERAPEUTIC MODULATOR OF GENE EXPRESSION FOR THE MANAGEMENT OF CHRONIC DISEASES. 2019 2 5956 38 TELOMERE AND TELOMERASE: BIOLOGICAL MARKERS OF ORGANIC VITAL FORCE STATE AND HOMEOPATHIC TREATMENT EFFECTIVENESS. BACKGROUND: PHILOSOPHICAL-SCIENTIFIC CORRELATIONS DESCRIBED IN PREVIOUS STUDIES SUGGEST THAT THE GENOME CAN BE THE BIOLOGICAL REPRESENTATION OF THE VITAL FORCE, WHILST THE DISEASE-PROMOTING EPIGENETIC ALTERATIONS WOULD BE THE BIOLOGICAL REPRESENTATION OF THE CHRONIC MIASMAS. IN THIS STUDY, WE EXPAND THE FUNCTIONAL CORRELATION BETWEEN VITAL FORCE AND CHROMOSOMES, DESCRIBING THE MECHANISM OF ACTION OF THE TELOMERE-TELOMERASE COMPLEX IN THE CONTEXT OF PHYSIOLOGICAL BALANCE. AIMS: THE AIM OF THE WORK IS TO STUDY THE ROLE OF THE TELOMERE-TELOMERASE COMPLEX IN CELL VITALITY, BIOLOGICAL AGING, AND THE HEALTH-DISEASE PROCESS, WITH THE GOAL OF PROPOSING THE USE OF TELOMERE LENGTH AS A BIOMARKER OF THE VITAL FORCE STATE AND THE EFFECTIVENESS OF HOMEOPATHIC TREATMENT. RESULTS: SIMILAR TO THE VITAL FORCE, TELOMERE LENGTH AND TELOMERASE ENZYME ACTIVITY PLAY AN IMPORTANT ROLE IN MAINTAINING CELLULAR VITALITY, BIOLOGICAL LONGEVITY, AND PHYSIOLOGICAL HOMEOSTASIS. TELOMERE SHORTENING FUNCTIONS AS A BIOMARKER OF VITAL IMBALANCE AND IS ASSOCIATED WITH NUMEROUS DISEASES AND HEALTH DISORDERS. ON THE OTHER HAND, HEALTH-PROMOTION PRACTICES NEUTRALIZE THE PATHOLOGICAL SHORTENING OF THE TELOMERES, ACTING THERAPEUTICALLY IN DISEASES OR AGE-DEPENDENT HEALTH DISORDERS. CONCLUSIONS: AS A HYPOTHETICAL BIOMARKER OF THE VITAL FORCE STATE, AN INTRA-INDIVIDUAL ANALYSIS OF THE MEAN LEUKOCYTE TELOMERE LENGTH BEFORE, DURING, AND AFTER HOMEOPATHIC TREATMENT CAN BE USED AS A BIOMARKER OF THERAPEUTIC EFFECTIVENESS. 2021 3 5948 19 TARGETING THE MOLECULAR & CELLULAR PILLARS OF HUMAN AGING WITH EXERCISE. BIOLOGICAL AGING IS THE MAIN DRIVER OF AGE-ASSOCIATED CHRONIC DISEASES. IN 2014, THE UNITED STATES NATIONAL INSTITUTE OF AGING (NIA) SPONSORED A MEETING BETWEEN SEVERAL INVESTIGATORS IN THE FIELD OF AGING BIOLOGY, WHO IDENTIFIED SEVEN BIOLOGICAL PILLARS OF AGING AND A CONSENSUS REVIEW, "GEROSCIENCE: LINKING AGING TO CHRONIC DISEASE," WAS PUBLISHED. THE PILLARS OF AGING DEMONSTRATED THE CONSERVATION OF AGING PATHWAYS IN DIVERSE MODEL ORGANISMS AND THUS REPRESENT A USEFUL FRAMEWORK WITH WHICH TO STUDY HUMAN AGING. IN THIS PRESENT REVIEW, WE REVISIT THE SEVEN PILLARS OF AGING FROM THE PERSPECTIVE OF EXERCISE AND DISCUSS HOW REGULAR PHYSICAL EXERCISE CAN MODULATE THESE PILLARS TO STAVE OFF AGE-RELATED CHRONIC DISEASES AND MAINTAIN FUNCTIONAL CAPACITY. 2023 4 33 23 A CASE STUDY OF CHIROPRACTIC MANAGEMENT OF PREGNANCY-RELATED HEARTBURN WITH POSTULATED FETAL EPIGENOME IMPLICATIONS. OBJECTIVE: THIS CASE STUDY REPORTS ON CHIROPRACTIC CARE FOR PREGNANCY-RELATED HEARTBURN. THE PURPOSE OF THIS ARTICLE IS TO RELATE THE BENEFIT OF CHIROPRACTIC TREATMENT FOR ONE INDIVIDUAL, TO CONTRAST CHIROPRACTIC MANAGEMENT WITH THE BIOMEDICAL STANDARD OF CARE FOR PREGNANCY-RELATED HEARTBURN, AND TO POINT TO POTENTIAL EPIGENETIC IMPLICATIONS OF THE STANDARD OF CARE. CLINICAL FEATURES: A 32-YEAR-OLD WOMAN WHO WAS 24 WEEKS PREGNANT PRESENTED WITH PERSISTENT HEARTBURN THAT SHE WAS TREATING WITH RANITIDINE (ZANTAC(R)) AND CALCIUM CARBONATE (TUMS(R)) DAILY AT THE INITIATION OF CHIROPRACTIC CARE. INTERVENTION AND OUTCOME: FINDINGS OF THE INITIAL EXAMINATION WERE THORACIC INTERSEGMENTAL DYSFUNCTION AND PAIN UPON PALPATION OF THE DIAPHRAGM, WITH HYPERTONICITY NOTED. THERAPY LOCALIZATION WAS POSITIVE FOR REFLEXES ASSOCIATED WITH THE ESOPHAGUS AND LOWER ESOPHAGEAL SPHINCTER, SUGGESTING SPASMS. EMOTIONAL COMPONENTS ALSO WERE IDENTIFIED IN ASSOCIATION WITH THE SYMPTOMS BY THE USE OF A MIND-BODY THERAPY CALLED NEUROEMOTIONAL TECHNIQUE. THE PATIENT WAS TREATED BY ADJUSTING THE THORACIC SPINE, MANUALLY RELEASING THE DIAPHRAGM SPASMS, AND RELEASING THE ESOPHAGEAL SPASM WITH AN ACTIVATOR (A SMALL HAND-HELD INSTRUMENT THAT CREATES A PERCUSSIVE FORCE). THE PATIENT WAS SYMPTOM-FREE AND DID NOT USE MEDICATION AFTER THE FIFTH TREATMENT. SHE WAS FOLLOWED THROUGHOUT THE REMAINDER OF HER PREGNANCY AND WAS ASYMPTOMATIC AND REQUIRED NO FURTHER TREATMENT. CONCLUSIONS: A LARGER STUDY SHOULD INVESTIGATE THE EFFECTIVENESS OF CHIROPRACTIC CARE FOR THE TREATMENT OF PREGNANCY-RELATED HEARTBURN. 2012 5 3393 26 HOST DETERMINANTS OF PRION STRAIN DIVERSITY INDEPENDENT OF PRION PROTEIN GENOTYPE. PHENOTYPIC DIVERSITY IN PRION DISEASES CAN BE SPECIFIED BY PRION STRAINS IN WHICH BIOLOGICAL TRAITS ARE PROPAGATED THROUGH AN EPIGENETIC MECHANISM MEDIATED BY DISTINCT PRP(SC) CONFORMATIONS. WE INVESTIGATED THE ROLE OF HOST-DEPENDENT FACTORS ON PHENOTYPIC DIVERSITY OF CHRONIC WASTING DISEASE (CWD) IN DIFFERENT HOST SPECIES THAT EXPRESS THE SAME PRION PROTEIN GENE (PRNP). TWO CWD STRAINS THAT HAVE DISTINCT BIOLOGICAL, BIOCHEMICAL, AND PATHOLOGICAL FEATURES WERE IDENTIFIED IN TRANSGENIC MICE THAT EXPRESS THE SYRIAN GOLDEN HAMSTER (SGH) PRNP. THE CKY STRAIN OF CWD HAD A SHORTER INCUBATION PERIOD THAN THE WST STRAIN OF CWD, BUT AFTER TRANSMISSION TO SGH, THE INCUBATION PERIOD OF CKY CWD WAS APPROXIMATELY 150 DAYS LONGER THAN WST CWD. LIMITED PROTEINASE K DIGESTION REVEALED STRAIN-SPECIFIC PRP(SC) POLYPEPTIDE PATTERNS THAT WERE MAINTAINED IN BOTH HOSTS, BUT THE SOLUBILITY AND CONFORMATIONAL STABILITY OF PRP(SC) DIFFERED FOR THE CWD STRAINS IN A HOST-DEPENDENT MANNER. WST CWD PRODUCED PRP(SC) AMYLOID PLAQUES IN THE BRAIN OF THE SGH THAT WERE PARTIALLY INSOLUBLE AND STABLE AT A HIGH CONCENTRATION OF PROTEIN DENATURANT. HOWEVER, IN TRANSGENIC MICE, PRP(SC) FROM WST CWD DID NOT ASSEMBLE INTO PLAQUES, WAS HIGHLY SOLUBLE, AND HAD LOW CONFORMATIONAL STABILITY. SIMILAR STUDIES USING THE HY AND DY STRAINS OF TRANSMISSIBLE MINK ENCEPHALOPATHY RESULTED IN MINOR DIFFERENCES IN PRION BIOLOGICAL AND PRP(SC) PROPERTIES BETWEEN TRANSGENIC MICE AND SGH. THESE FINDINGS INDICATE THAT HOST-SPECIFIC PATHWAYS THAT ARE INDEPENDENT OF PRNP CAN ALTER THE PRP(SC) CONFORMATION OF CERTAIN PRION STRAINS, LEADING TO CHANGES IN THE BIOPHYSICAL PROPERTIES OF PRP(SC), NEUROPATHOLOGY, AND CLINICAL PRION DISEASE. IMPORTANCE: PRIONS ARE MISFOLDED PATHOGENIC PROTEINS THAT CAUSE NEURODEGENERATION IN HUMANS AND ANIMALS. TRANSMISSIBLE PRION DISEASES EXHIBIT A SPECTRUM OF DISEASE PHENOTYPES AND THE BASIS OF THIS DIVERSITY IS ENCODED IN THE STRUCTURE OF THE PATHOGENIC PRION PROTEIN AND PROPAGATED BY AN EPIGENETIC MECHANISM. IN THE PRESENT STUDY, WE INVESTIGATED PRION DIVERSITY IN TWO HOSTS SPECIES THAT EXPRESS THE SAME PRION PROTEIN GENE. WHILE PRIOR REPORTS HAVE DEMONSTRATED THAT PRION STRAIN PROPERTIES ARE STABLE UPON INFECTION OF THE SAME HOST SPECIES AND PRION PROTEIN GENOTYPE, OUR FINDINGS INDICATE THAT CERTAIN PRION STRAINS CAN UNDERGO DRAMATIC CHANGES IN BIOLOGICAL PROPERTIES THAT ARE NOT DEPENDENT ON THE PRION PROTEIN. THEREFORE, HOST FACTORS INDEPENDENT OF THE PRION PROTEIN CAN AFFECT PRION DIVERSITY. UNDERSTANDING HOW HOST PATHWAYS CAN MODIFY PRION DISEASE PHENOTYPES MAY PROVIDE CLUES ON HOW TO ALTER PRION FORMATION AND LEAD TO TREATMENTS FOR PRION, AND OTHER, HUMAN NEURODEGENERATIVE DISEASES OF PROTEIN MISFOLDING. 2015 6 1732 24 DYSTONIA AND LEVODOPA-INDUCED DYSKINESIAS IN PARKINSON'S DISEASE: IS THERE A CONNECTION? DYSTONIA AND LEVODOPA-INDUCED DYSKINESIA (LID) ARE BOTH HYPERKINETIC MOVEMENT DISORDERS. DYSTONIA ARISES MOST OFTEN SPONTANEOUSLY, ALTHOUGH IT MAY BE SEEN AFTER STROKE, INJURY, OR AS A RESULT OF GENETIC CAUSES. LID IS ASSOCIATED WITH PARKINSON'S DISEASE (PD), EMERGING AS A CONSEQUENCE OF CHRONIC THERAPY WITH LEVODOPA, AND MAY BE EITHER DYSTONIC OR CHOREIFORM. LID AND DYSTONIA SHARE IMPORTANT PHENOMENOLOGICAL PROPERTIES AND MECHANISMS. BOTH LID AND DYSTONIA ARE GENERATED BY AN INTEGRATED CIRCUIT INVOLVING THE CORTEX, BASAL GANGLIA, THALAMUS AND CEREBELLUM. THEY ALSO SHARE DYSREGULATION OF STRIATAL CHOLINERGIC SIGNALING AND ABNORMALITIES OF STRIATAL SYNAPTIC PLASTICITY. THE LONG DURATION NATURE OF BOTH LID AND DYSTONIA SUGGESTS THAT THERE MAY BE UNDERLYING EPIGENETIC DYSREGULATION AS A PROXIMATE CAUSE. WHILE BOTH MAY IMPROVE AFTER INTERVENTIONS SUCH AS DEEP BRAIN STIMULATION (DBS), NEITHER CURRENTLY HAS A SATISFACTORY MEDICAL THERAPY, AND MANY PEOPLE ARE DISABLED BY THE SYMPTOMS OF DYSTONIA AND LID. FURTHER STUDY OF THE FUNDAMENTAL MECHANISMS CONNECTING THESE TWO DISORDERS MAY LEAD TO NOVEL APPROACHES TO TREATMENT OR PREVENTION. 2019 7 6784 19 [CHRONIC STRESS AND EPIGENETICS. RELATION BETWEEN ACADEMIC SCIENCES AND THEOLOGY]. THE AUTHOR GIVES A SHORT ACCOUNT ON THE PRINCIPLES OF SELYE'S STRESS THEORY, AND DISCUSSES SIMILARITIES AND DISSIMILARITIES OF ACUTE AND CHRONIC STRESS. BOTH THE EXTERNAL, AND THE INTERNAL ENVIRONMENT, AS WELL AS THE PSYCHO-MENTAL STATUS ARE INVOLVED IN THE NOTION OF THE ENVIRONMENT. BASIC PRINCIPLES OF EPIGENETICS ARE REVIEWED: INTERACTION BETWEEN ENVIRONMENT AND GENES, NEUROENDOCRINE AND ENZYMATIC MECHANISMS INVOLVED IN SILENCING AND ACTIVATION OF GENES, NOTIONS OF PHENOTYPIC PLASTICITY, AND EPIGENETIC REPROGRAMMING ARE DISCUSSED. EPIGENETIC MECHANISMS OF INTERRELATION BETWEEN PATHOLOGICAL CLINICAL STATES (DISEASES) AND THE CHARACTERISTIC PHENOTYPES, CAUSATIVE ROLE OF PSYCHO-MENTAL STATUS IN EVOKING PATHOLOGICAL SOMATIC ALTERATIONS, AND THE POTENTIAL THERAPEUTIC CONSEQUENCES ARE BRIEFLY DISCUSSED. THE ETIOLOGICAL ROLE OF CHRONIC, CIVILIZATION STRESS IN PRODUCING THE WORLDWIDE INCREMENT OF CARDIOVASCULAR MORBIDITY IS CITED, ARGUMENTATION AND CRITICISM OF THE CURRENT THERAPEUTICAL PRACTICE IS DISCUSSED. THE AUTHOR CONCLUDES THAT RECENT ADVANCES IN EPIGENETIC KNOWLEDGE SEEM TO SOLVE THE CONTROVERSY BETWEEN THE ACADEMIC AND THEOLOGICAL SCIENCES. 2012 8 3598 14 IMPLICATIONS ON HYPNOTHERAPY: NEUROPLASTICITY, EPIGENETICS AND PAIN. WE PROVIDE A BRIEF REVIEW ABOUT THE SIGNIFICANCE OF HYPNOSIS WITH RESPECT TO APPLICATIONS AND PHYSIOLOGICAL PROCESSES IN HYPNOTHERAPY. OUR REVIEW CONCLUDES THAT HYPNOSIS IS A PROMISING METHOD TO MANAGE ACUTE AND CHRONIC PAIN. IN ADDITION, WE DISCUSS INDICATIONS POINTING TOWARD THE VIEW THAT HYPNOSIS CAN INDUCE CHANGES IN NEUROPLASTICITY POSSIBLY INVOLVING EPIGENETIC MECHANISMS. 2021 9 3845 11 IS AGING A "RETRO"SPECTIVE EVENT? REACTIVATION OF ENDOGENOUS RETROVIRUSES (ERVS), THE RELICS OF ANCIENT INFECTIONS, HAS BEEN IMPLICATED IN A NUMBER OF DISEASE CONTEXTS. IN THIS ISSUE OF CELL, LIU ET AL. SHOW HOW REACTIVATION OF ERVS IN OLD AGE CAN INDUCE SENESCENCE. THIS AWAKENING OF ERVS IS ASSOCIATED WITH THEIR EPIGENETIC DEREPRESSION AND CONTRIBUTES TO AGE-ASSOCIATED CHRONIC INFLAMMATION. 2023 10 181 21 ACCELERATED EPIGENETIC AGING MEDIATES THE ASSOCIATION BETWEEN VITAMIN D LEVELS AND KNEE PAIN IN COMMUNITY-DWELLING INDIVIDUALS. OBJECTIVES: TO EXAMINE THE RELATIONSHIP BETWEEN VITAMIN D STATUS AND PAIN INTENSITY AND DISABILITY IN INDIVIDUALS WITH AND WITHOUT KNEE PAIN, AND TO EXAMINE THE ROLE OF EPIGENETICS IN THIS RELATIONSHIP. DESIGN: CROSS-SECTIONAL ANALYSIS OF DATA FROM THE UPLOAD-2 STUDY (UNDERSTANDING PAIN AND LIMITATIONS IN OSTEOARTHRITIC DISEASE-2). PARTICIPANTS: 189 INDIVIDUALS AGED 45-65 YEARS AND OLDER. MEASUREMENTS: SERUM VITAMIN D LEVELS, PAIN RELATED INTERFERENCE AND CHARACTERISTIC PAIN INTENSITY MEASURES, AND THE EPIGENETIC CLOCK GRIMAGE DERIVED FROM BLOOD ANALYSES. RESULTS: LOWER VITAMIN D WAS ASSOCIATED WITH ADVANCED EPIGENETIC AGING (AGEACCELGRIM), GREATER PAIN AND DISABILITY AND THAT (AGEACCELGRIM) MEDIATED THE RELATIONSHIP BETWEEN VITAMIN D STATUS AND SELF-REPORTED PAIN (AB = -0.0799; CI [-0.1492, -0.0237]) AND DISABILITY (AB = -0.0669; CI [-0.1365, -0.0149]) OUTCOMES. CONCLUSION: THESE DATA SUPPORT THE NOTION THAT LIFESTYLE FACTORS SUCH AS NUTRITION STATUS PLAY A KEY ROLE IN AGING PROCESS, AS WELL AS THE DEVELOPMENT AND MAINTENANCE OF AGE-RELATED DISEASES SUCH AS PAIN. MODIFYING NUTRITION STATUS COULD HELP PROMOTE HEALTHY AGING AND REDUCE PAIN. 2022 11 2603 30 EPIGENETICS, ENVIRONMENT AND EPIDEMIOLOGY: AN INTERVIEW WITH KARL KELSEY. IN THIS INTERVIEW, PROFESSOR KARL KELSEY SPEAKS WITH STORM JOHNSON, COMMISSIONING EDITOR FOR EPIGENOMICS, ON HIS WORK TO DATE IN THE FIELD OF ENVIRONMENTAL EPIGENOMICS AND EPIDEMIOLOGY. DR KARL KELSEY, MD, MOH IS A PROFESSOR OF EPIDEMIOLOGY AND PATHOLOGY AND LABORATORY MEDICINE AT BROWN UNIVERSITY. HE IS THE FOUNDING DIRECTOR OF THE CENTER FOR ENVIRONMENTAL HEALTH AND TECHNOLOGY AND HEAD OF THE ENVIRONMENTAL HEALTH SECTION AT THE DEPARTMENT OF EPIDEMIOLOGY. DR KELSEY IS INTERESTED IN THE APPLICATION OF LABORATORY-BASED BIOMARKERS IN ENVIRONMENTAL DISEASE, WITH EXPERIENCE IN CHRONIC DISEASE EPIDEMIOLOGY AND TUMOR BIOLOGY. THE GOALS OF HIS WORK INCLUDE A MECHANISTIC UNDERSTANDING OF INDIVIDUAL SUSCEPTIBILITY TO EXPOSURE-RELATED CANCERS. IN ADDITION, HIS LABORATORY IS INTERESTED IN TUMOR BIOLOGY, INVESTIGATING SOMATIC ALTERATIONS IN TUMOR TISSUE FROM THE PATIENTS WHO HAVE DEVELOPED EXPOSURE-RELATED CANCERS. THIS WORK INVOLVES THE USE OF AN EPIDEMIOLOGIC APPROACH TO CHARACTERIZE EPIGENETIC AND GENETIC ALTERATION OF GENES IN THE CAUSAL PATHWAY FOR MALIGNANCY. ACTIVE WORK INCLUDES SEVERAL STUDIES OF INDIVIDUAL SUSCEPTIBILITY TO CANCER. DR KELSEY'S LABORATORY MAINLY INVESTIGATES SUSCEPTIBILITY TO SMOKING-RELATED LUNG CANCER AND STUDIES MULTI-RACIAL AND ETHNIC POPULATIONS. IN ADDITION, THE LABORATORY IS ALSO INVOLVED WITH THE STUDY OF INHERITED SUSCEPTIBILITY TO BRAIN TUMORS AND PANCREATIC CANCER. MAJOR CASE CONTROL STUDIES THAT ARE ONGOING IN THE LABORATORY INCLUDE STUDIES DESIGNED TO UNDERSTAND INHERITED AND ACQUIRED SUSCEPTIBILITY IN HEAD AND NECK CANCERS. THE LABORATORY IS ALSO INVOLVED IN A CASE CONTROL STUDY OF ASBESTOS-ASSOCIATED MESOTHELIOMA, ARSENIC EXPOSURE, CIGARETTE SMOKING AND BLADDER CANCER. CONSIDERABLE WORK IS BEING DEVOTED TO UNDERSTANDING THE MECHANISMS OF ACTION OF BOTH ASBESTOS AND ARSENIC INCLUDING THEIR ABILITY TO AFFECT PROMOTER METHYLATION AND GENE SILENCING IN CARCINOGENESIS. RECENT LABORATORY STUDIES INCLUDES AN INTEREST IN USING NEWLY DEVELOPED DNA METHYLATION BIOMARKERS TO PROBE IMMUNE PROFILES FROM ARCHIVED BLOOD. DR KELSEY RECEIVED HIS MD FROM THE UNIVERSITY OF MINNESOTA AND MASTERS OF OCCUPATIONAL HEALTH FROM HARVARD UNIVERSITY. 2022 12 1452 19 DISCORDANT INTESTINAL MALROTATION IN ADULT MONOZYGOTIC TWINS DISCOVERED INCIDENTALLY DURING LAPAROSCOPIC GASTRIC BYPASS: A CASE REPORT AND REVIEW OF THE LITERATURE. INTRODUCTION AND IMPORTANCE: INTESTINAL MALROTATION IS AN UNCOMMON ENTITY IN THE ADULT POPULATION; MORE SO IN MONOZYGOTIC TWINS, WHERE CONCORDANCE IS EXPECTED. IN LITERATURE, DISCORDANT INTESTINAL MALROTATION HAS ONLY BEEN DISCOVERED WHEN ONE TWIN BECAME SYMPTOMATIC, AND THE OTHER WAS SCREENED. TO THE BEST OF OUR KNOWLEDGE, THIS IS THE FIRST DOCUMENTED CASE OF DISCORDANT ADULT TYPE INTESTINAL MALROTATION IN OTHERWISE ASYMPTOMATIC MONOZYGOTIC TWINS DISCOVERED INCIDENTALLY DURING LAPAROSCOPIC ROUX-EN-Y GASTRIC BYPASS (LRYGB). CASE PRESENTATION: TWINS A AND B MET THE NIH CRITERIA FOR BARIATRIC SURGERY, NEITHER HAVING SYMPTOMS OF ACUTE OR CHRONIC VOLVULUS OR HISTORY OF INTRAABDOMINAL SURGERY. TWIN A HAD A LRYGB PERFORMED BY A TRAINED BARIATRIC SURGEON, NOTING NO ANATOMIC ANOMALIES. 5 MONTHS LATER, TWIN B HAD LRYGB AND INTESTINAL MALROTATION WAS DIAGNOSED INCIDENTALLY. CLINICAL DISCUSSION: DIAGNOSIS OF INTESTINAL MALROTATION IS RARE IN ADULTS, USUALLY DISCOVERED AFTER BECOMING SYMPTOMATIC OR DURING ABDOMINAL IMAGING FOR ANOTHER INDICATION. TWO CASES OF DISCORDANT INTESTINAL MALROTATION IN MONOZYGOTIC TWINS HAVE BEEN DOCUMENTED, BOTH DISCOVERED WHEN ONE TWIN BECAME SYMPTOMATIC DUE TO ACUTE VOLVULUS, SUGGESTING EPIGENETIC PHENOMENA. WHEN DISCOVERED INCIDENTALLY DURING SURGERY, PATIENTS CAN SAFELY UNDERGO THEIR INTENDED PROCEDURE, BUT LITERATURE SUGGESTS PROPHYLACTIC DIVISION OF LADD'S BANDS, WHILE APPENDECTOMY IS LEFT TO THE DISCRETION OF THE SURGEON. CONCLUSIONS: INTESTINAL MALROTATION APPEARS TO BE ASSOCIATED WITH EPIGENETIC PHENOMENA AND IF DISCOVERED INCIDENTALLY DURING SURGERY, THE PROPOSED PROCEDURE CAN BE CARRIED OUT BY AN EXPERIENCED SURGEON, IN ADDITION TO DIVISION OF LADD'S BANDS AND APPENDECTOMY. 2022 13 1145 19 CONCURRENT DIAGNOSIS OF ADENOMYOSIS AND CONGENITAL UTERINE ANOMALIES: A REVIEW. BACKGROUND: ADENOMYOSIS AND CONGENITAL UTERINE ANOMALIES (CUAS) CAN COMPROMISE REPRODUCTIVE POTENTIAL AND MAY COEXIST IN THE SAME PATIENT, ESPECIALLY IN CASES OF INFERTILITY. THIS REVIEW (CRD42022382850) AIMS TO EVALUATE THE PUBLISHED CASES OF CONCURRENT ADENOMYOSIS AND SYNDROMIC AND NONSYNDROMIC CUAS. METHODS: A LITERATURE SEARCH FOR SUITABLE ARTICLES PUBLISHED IN THE ENGLISH LANGUAGE WAS PERFORMED USING THE FOLLOWING DATABASES FROM INCEPTION TO 30 NOVEMBER 2022: MEDLINE, EMBASE, GLOBAL HEALTH, THE COCHRANE LIBRARY, HEALTH TECHNOLOGY ASSESSMENT DATABASE, AND WEB OF SCIENCE. ARTICLES INCLUDING BOTH CUAS AND ADENOMYOSIS, WITH DATA ABOUT THEIR POTENTIAL RELATIONSHIP, WERE INCLUDED. RESULTS: THE LITERATURE SEARCH RETRIEVED 14 ARTICLES THAT MET THE PURPOSE OF THIS REVIEW AND SUMMARIZED THE MOST RECENT FINDINGS REGARDING THE CONCURRENT DIAGNOSIS OF ADENOMYOSIS AND CUAS. CONCLUSIONS: ADENOMYOSIS CAN BE FOUND IN BOTH SYNDROMIC AND NONSYNDROMIC CUAS, AND MAY ARISE FROM SEVERAL ETIOLOGIES. THE HYPOTHESIS THAT OBSTRUCTIONS IN CUAS INCREASE UTERINE PRESSURE AND PROMOTE THE DEVELOPMENT OF ADENOMYOSIS REMAINS TO BE FURTHER ELUCIDATED, AND ADDITIONAL FINDINGS MAY ALSO PLAY A ROLE. THE PATIENT'S GENETIC, EPIGENETIC, AND HORMONAL PATTERNS, AS WELL AS NORMAL PHYSIOLOGICAL PROCESSES, SUCH AS PREGNANCY, MAY INFLUENCE THE GROWTH OF ADENOMYOSIS. 2023 14 5809 22 STRAWBERRY AND HUMAN HEALTH: EFFECTS BEYOND ANTIOXIDANT ACTIVITY. THE USEFULNESS OF A DIET RICH IN VEGETABLES AND FRUITS ON HUMAN HEALTH HAS BEEN WIDELY RECOGNIZED: A HIGH INTAKE OF ANTIOXIDANT AND BIOACTIVE COMPOUNDS MAY IN FACT PLAY A CRUCIAL ROLE IN THE PREVENTION OF SEVERAL DISEASES, SUCH AS CANCER, CARDIOVASCULAR, NEURODEGENERATIVE, AND OTHER CHRONIC PATHOLOGIES. THE STRAWBERRY (FRAGARIA X ANANASSA DUCH.) POSSESSES A REMARKABLE NUTRITIONAL COMPOSITION IN TERMS OF MICRONUTRIENTS, SUCH AS MINERALS, VITAMIN C, AND FOLATES, AND NON-NUTRIENT ELEMENTS, SUCH AS PHENOLIC COMPOUNDS, THAT ARE ESSENTIAL FOR HUMAN HEALTH. ALTHOUGH STRAWBERRY PHENOLICS ARE KNOWN MAINLY FOR THEIR ANTI-INFLAMMATORY AND ANTIOXIDANT ACTIONS, RECENT STUDIES HAVE DEMONSTRATED THAT THEIR BIOLOGICAL ACTIVITIES ALSO SPREAD TO OTHER PATHWAYS INVOLVED IN CELLULAR METABOLISM AND CELLULAR SURVIVAL. THIS PAPER HAS THE MAIN OBJECTIVE OF REVIEWING CURRENT INFORMATION ABOUT THE POTENTIAL MECHANISMS INVOLVED IN THE EFFECTS ELICITED BY STRAWBERRY POLYPHENOLS ON HUMAN HEALTH, DEVOTING SPECIAL ATTENTION TO THE LATEST FINDINGS. 2014 15 5356 25 REAC-INDUCED ENDOGENOUS BIOELECTRIC CURRENTS IN THE TREATMENT OF VENOUS ULCERS: A THREE-ARM RANDOMIZED CONTROLLED PROSPECTIVE STUDY. INTRODUCTION: ENDOGENOUS BIOELECTRIC FIELDS (EBFS) PLAY A FUNDAMENTAL ROLE IN PROMOTING REPAIR AND REGENERATION PROCESSES, INCLUDING IN LEG VENOUS ULCERS (LVUS). UNFORTUNATELY, THE MECHANISM UNDERLYING THE PRODUCTION OF EBFS IS EASILY ALTERED BY INFECTIOUS, TRAUMATIC, AND EPIGENETIC FACTORS. THIS ALTERATION IS ONE OF THE DETERMINING FACTORS FOR THE CHRONICITY OF LVUS. THIS STUDY INVESTIGATES HOW RADIOELECTRIC ASYMMETRIC CONVEYER (REAC) TECHNOLOGY TREATMENTS, SPECIFICALLY DESIGNED TO OPTIMIZE EBFS, AND IN PARTICULAR TISSUE OPTIMIZATION-REPARATIVE (TO-RPR) TREATMENT, CAN IMPROVE THE RESULTS OF STANDARD DRESSING WITH AND WITHOUT ELASTIC COMPRESSION IN LVU PATIENTS. METHODS: A TOTAL OF 30 PATIENTS WERE ENROLLED (12 MALES AND 18 FEMALES) AND RANDOMIZED INTO THREE GROUPS. ALL PATIENTS COMPLETED THE STUDY. GROUP A WAS TREATED WITH STANDARD DRESSING, ELASTIC COMPRESSION, AND REAC TO-RPR TREATMENT; GROUP B WAS TREATED WITH STANDARD DRESSING AND REAC TO-RPR TREATMENT; AND GROUP C WAS TREATED WITH STANDARD DRESSING AND ELASTIC COMPRESSION. RESULTS: THE RESULTS SHOW THAT THE COMBINATION OF REAC TREATMENT AND STANDARD DRESSING ASSOCIATED WITH ELASTIC COMPRESSION HAS THE GREATEST THERAPEUTIC EFFICACY IN PROMOTING THE HEALING PROCESS FOR ULCERS, REDUCING PERCEIVED PAIN, AND IMPROVING THE QUALITY OF LIFE OF THE PATIENTS TREATED. CONCLUSIONS: FURTHER STUDIES WILL BE USEFUL TO INVESTIGATE THESE PROSPECTIVE RESULTS. 2020 16 3059 29 GENOME-WIDE DNA METHYLATION ANALYSIS OF ASTRAGALUS AND DANSHEN ON THE INTERVENTION OF MYOFIBROBLAST ACTIVATION IN IDIOPATHIC PULMONARY FIBROSIS. BACKGROUND: IDIOPATHIC PULMONARY FIBROSIS (IPF), A CHRONIC PROGRESSIVE INTERSTITIAL LUNG DISEASE OF UNKNOWN ETIOLOGY, IS CHARACTERIZED BY CONTINUOUS DAMAGE TO ALVEOLAR EPITHELIAL CELLS, ABNORMAL REPAIR OF ALVEOLAR TISSUE, AND ALVEOLAR WALL SCAR FORMATION. CURRENTLY, THE RECOMMENDED TREATMENT FOR IPF IN WESTERN MEDICINE IS RELATIVELY LIMITED. IN CONTRAST, TRADITIONAL CHINESE MEDICINE AND COMPOUND PRESCRIPTIONS SHOW ADVANTAGES IN THE DIAGNOSIS AND TREATMENT OF IPF, WHICH CAN BE ATTRIBUTED TO THEIR MULTI-CHANNEL AND MULTI-TARGET CHARACTERISTICS AND MINIMAL SIDE-EFFECTS. THE PURPOSE OF THIS STUDY WAS TO FURTHER CORROBORATE THE EFFECTIVENESS AND SIGNIFICANCE OF THE TRADITIONAL CHINESE MEDICATIONS ASTRAGALUS AND DANSHEN IN IPF TREATMENT. METHODS: WE PERFORMED WHOLE-GENOME METHYLATION ANALYSIS ON NINE RAT LUNG TISSUE SAMPLES TO DETERMINE THE EPIGENETIC VARIATION BETWEEN IPF AND NON-FIBROTIC LUNGS USING GENE ONTOLOGY AND KYOTO ENCYCLOPEDIA OF GENES AND GENOMES PATHWAY ENRICHMENT ANALYSES AND QUANTITATIVE REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTIONS. RESULTS: WE IDENTIFIED DIFFERENTIALLY METHYLATED REGIONS AND 105 ASSOCIATED KEY FUNCTIONAL GENES IN SAMPLES RELATED TO IPF AND CHINESE MEDICINE TREATMENT. BASED ON THE METHYLATION LEVELS AND GENE EXPRESSION PROFILES BETWEEN THE CHINESE MEDICINE INTERVENTION AND PULMONARY FIBROSIS MODEL GROUPS, WE SPECULATED THAT ASTRAGALUS AND SALVIA MILTIORRHIZA (TRADITIONALLY KNOWN AS DANSHEN) ACT ON THE ISL1, FORKHEAD BOX O3, AND SONIC HEDGEHOG GENES VIA REGULATION AT TRANSCRIPTIONAL AND EPIGENETIC LEVELS DURING IPF. CONCLUSIONS: THESE FINDINGS PROVIDE NOVEL INSIGHTS INTO THE EPIGENETIC REGULATION OF IPF, INDICATE THE EFFECTIVENESS OF ASTRAGALUS AND DANSHEN IN TREATING IPF, AND SUGGEST SEVERAL PROMISING THERAPEUTIC TARGETS FOR PREVENTING AND TREATING IPF. 2023 17 6779 16 [BIO-PSYCHO-SOCIAL THERAPY FOR STRESS-INDUCED CHRONIC PAIN]. BIO-PSYCHO-SOCIAL THERAPY FOR STRESS-INDUCED CHRONIC PAIN ABSTRACT. AGAINST THE BACKGROUND OF LATEST NEUROBIOLOGICAL AND EPIGENETIC FINDINGS THE BIO-PSYCHO-SOCIAL MODEL OF DISEASE IS OUTLINED OFTEN MISINTERPRETED IN THE CONTEXT OF CHRONIC PAIN. IT REPRESENTS THE BASIC PRINCIPLE FOR A PERSONALIZED TREATMENT OF STRESS-INDUCED CHRONIC PAIN. CONSEQUENCES FOR DIAGNOSTIC PROCEDURES ARE DELINEATED TO DETECT THIS PATHOGENETIC SUBGROUP OF CHRONIC PAIN PATIENTS (E.G. FIBROMYALGIA, BACK PAIN, TEMPOROMANDIBULAR DYSFUNCTION, TENSION HEADACHE). FINALLY, THE PRINCIPLES OF A BIO-PSYCHO-SOCIAL TREATMENT PROGRAM WITH HIGH EFFICIENCY ARE PRESENTED. 2020 18 5154 25 PRAKRITI-BASED MEDICINE: A STEP TOWARDS PERSONALIZED MEDICINE. THE CONCEPT OF PERSONALIZED MEDICINE HAS BEEN AROUND FOR AS LONG AS PEOPLE HAVE BEEN PRACTICING MEDICINE. FROM CHARAKA TO HIPPOCRATES, ALL HAVE PRACTICED THE PERSONALIZED APPROACH FOR TREATING A DISEASE. IN THE 21(ST) CENTURY, PERSONALIZED MEDICINE IS ALL ABOUT DNA. WHEREAS THE SINGLE NUCLEOTIDE POLYMORPHISM (SNP) AND EPIGENETIC FACTORS INFLUENCE DRUG RESPONSE AND FORM THE BASIS OF PERSONALIZED MEDICINE, THE TRIDOSHA THEORY FORMS THE BASIS OF PRAKRITI-BASED MEDICINE. IT IS WELL ESTABLISHED BY NOW THAT WESTERN ALLOPATHIC MEDICINE IS EXCELLENT IN HANDLING ACUTE MEDICAL CRISES, WHEREAS AYURVEDA HAS SUCCESSFULLY DEMONSTRATED AN ABILITY TO MANAGE CHRONIC DISORDERS THAT WESTERN MEDICINE HAS BEEN UNABLE TO CURE. WITH EFFECTIVE INTEGRATION OF 'OMICS' PRAKRITI-BASED MEDICINE CAN PLAY A VITAL ROLE IN THIS CHANGING SCENARIO OF GLOBAL HEALTH WISDOM AS AYURVEDA OFFERS ITS MODALITIES BY WAY OF AHARA (DIET), VIHARA (LIFESTYLE), AND AUSHADHI (MEDICATION), WHICH ARE THE THREE PILLARS OF PRAKRITI-BASED MEDICINE MAKING IT A HOLISTIC SCIENCE. PRAKRITI-BASED MEDICINE AND OTHER TRADITIONAL MEDICINE SYSTEMS HAVE THE POTENTIAL TO OFFER REMEDIES TO THE CHALLENGING HEALTH ISSUES LIKE ADVERSE DRUG REACTIONS, DRUG WITHDRAWALS, AND ECONOMIC DISPARITIES AMONG FEW. AN INTEGRATIVE GLOBAL APPROACH COULD DO WONDERS TO HEALTH SCIENCES BENEFITING A BROAD SPECTRUM OF PATIENTS. 2011 19 4912 23 PAIN INTERFERENCE MEDIATES THE ASSOCIATION BETWEEN EPIGENETIC AGING AND GRIP STRENGTH IN MIDDLE TO OLDER AGED MALES AND FEMALES WITH CHRONIC PAIN. INTRODUCTION: CHRONIC PAIN IS ONE OF THE LEADING CAUSES OF DISABILITY THAT MAY ACCELERATE BIOLOGICAL AGING AND REDUCE PHYSICAL FUNCTION. EPIGENETIC CLOCKS PROVIDE AN ESTIMATE OF HOW THE SYSTEM AGES AND CAN PREDICT HEALTH OUTCOMES SUCH AS PHYSICAL FUNCTION. PHYSICAL FUNCTION DECLINES MAY BE ATTRIBUTED TO DECREASES IN MUSCLE QUALITY DUE TO DISUSE THAT CAN BE MEASURED QUICKLY AND NONINVASIVELY USING GRIP STRENGTH. THE PURPOSE OF THIS STUDY WAS TO EXPLORE THE ASSOCIATIONS AMONG SELF-REPORTED PAIN, GRIP STRENGTH, AND EPIGENETIC AGING IN THOSE WITH CHRONIC PAIN. METHODS: PARTICIPANTS (57.91 +/- 8.04 YEARS) COMPLETED PAIN QUESTIONNAIRES, A BLOOD DRAW AND HAND GRIP STRENGTH TASK. WE USED AN EPIGENETIC CLOCK PREVIOUSLY ASSOCIATED WITH KNEE PAIN (DNAMGRIMAGE), AND USED THE SUBSEQUENT DIFFERENCE OF PREDICTED EPIGENETIC AGE FROM CHRONOLOGICAL AGE (DNAMGRIMAGE-DIFFERENCE). RESULTS: EXPLORATORY PATHWAY ANALYSES REVEALED THAT PAIN INTENSITY MEDIATED THE ASSOCIATION BETWEEN DNAMGRIMAGE-DIFFERENCE AND HANDGRIP STRENGTH IN MALES ONLY (BETA = -0.1115; CI [-0.2929, -0.0008]) AND PAIN INTERFERENCE MEDIATED THE ASSOCIATION BETWEEN DNAMGRIMAGE-DIFFERENCE AND HANDGRIP STRENGTH IN MALES BETA = -0.1401; CI [-0.3400, -0.0222]), AND FEMALES (BETA = -0.024; CI [-0.2918, -0.0020]). DISCUSSION: CHRONIC KNEE PAIN MAY ACCELERATE EPIGENETIC AGING PROCESSES THAT MAY INFLUENCE HANDGRIP STRENGTH IN OLDER AGE ADULTS. CHRONIC PAIN COULD BE A SYMPTOM OF THE AGING BODY THUS CONTRIBUTING TO DECLINES IN MUSCULOSKELETAL FUNCTION IN LATER LIFE. 2023 20 1016 23 CIITA EXPRESSION IS REGULATED BY HISTONE DEACETYLASE ENZYMES AND HAS A ROLE IN ALPHA-SYNUCLEIN PRE-FORMED FIBRIL-INDUCED ANTIGEN PRESENTATION IN MURINE MICROGLIAL CELL LINE. AIM: PARKINSON'S DISEASE (PD) IS A CHRONIC NEURODEGENERATIVE DISORDER RELATED WITH SEVERAL GENETIC AND EPIGENETIC FACTORS. IN THE CONTEXT OF EPIGENETIC FACTORS, HISTONE ACETYLATION IS ONE OF THE MOST ASSOCIATED MECHANISMS WITH PARKINSON'S DISEASE PROGRESSION. THIS STUDY INVESTIGATES THE EFFECTS OF THE INCREASED HISTONE ACETYLATION ON ANTIGEN PRESENTATION IN MICROGLIAL CELLS WHICH WERE INDUCED BY PRE-FORMED FIBRILS OF ALPHA-SYNUCLEIN (PFF ALPHA-SYNUCLEIN). METHODS: PARKINSON'S DISEASE MODEL WAS CREATED WITH PFF ALPHA-SYNUCLEIN ADMINISTRATION TO THE BV-2 MICROGLIAL CELLS. BV-2 CELLS WERE CO-TREATED WITH CUDC-907 AND TMP-195 TO INCREASE HISTONE ACETYLATION IN THE PRESENCE OF ALPHA-SYNUCLEIN. ANTIGEN REPRESENTATION WAS EVALUATED BY DETERMINING EXPRESSION LEVELS OF MAJOR HISTOCOMPATIBILITY COMPLEX-II (MHC-II) AND CLASS-II MAJOR HISTOCOMPATIBILITY COMPLEX (CIITA). RESULTS: OUR RESULTS SHOWED THAT PFF ALPHA-SYNUCLEIN SIGNIFICANTLY INCREASED MHC-II EXPRESSION, AND THAT EFFECT WAS MOST SEVERE AT 6 H OF ADMINISTRATION OF ALPHA-SYNUCLEIN. INCREASING HISTONE ACETYLATION VIA CUDC-907 AND TMP-195 ENHANCED MHC-II LEVELS EXPRESSION, WHICH WAS MORE SEVERE IN CUDC-907. ADDITIONALLY, CIITA EXPRESSION LEVELS WERE SIGNIFICANTLY INCREASED WITH PFF ALPHA-SYNUCLEIN ADMINISTRATION AND INTENSIFIED WITH THE CO-TREATMENT OF CUDC-907 AND TMP-195. FURTHERMORE, PFF ALPHA-SYNUCLEIN CAUSED A TIME-DEPENDENT INCREASE IN THE IFN-GAMMA (IFN-?) AND INTERLEUKIN-16(IL-16) LEVELS, AND THAT INCREASE WAS POTENTIATED WITH CUDC-907 AND TMP-195. CONCLUSION: CHANGES IN MHC-II AND CIITA EXPRESSION INDICATE THAT HISTONE ACETYLATION INCREASES THE ANTIGEN PRESENTATION PROPERTIES OF MICROGLIAL CELLS AFTER PFF ALPHA-SYNUCLEIN OR HISTONE DEACETYLASE INHIBITOR (HDACI) ADMINISTRATION. OUR RESULTS SHOW THAT MICROGLIAL ANTIGEN PRESENTATION MIGHT HAVE AN ESSENTIAL ROLE IN THE PATHOLOGY OF PARKINSON'S DISEASE, AND ALPHA-SYNUCLEIN LIKELY TO PLAY A PRIMARY ROLE IN THIS MECHANISM. 2022